Neil Kaplowitz, MD

Title(s)Professor of Medicine
AddressHMR 101
Health Sciences Campus
Los Angeles CA 90089-9091
Phone+1 323 442 5576
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    Other Positions
    Title(s)USC Associates/Thomas H. Brem Chair in Medicine

    Title(s)Chief, Division of Gastroenterology and Liver Diseases


    Collapse Biography 
    Collapse Awards and Honors
    Western Gastroenterology 1986Research Prize
    Association of American Physicians1988Member
    NIH1992Merit Award
    Department of Veterans Affairs 1993William S. Middleton Award
    New York University School of Medicine1994Solomon A. Berson Medical Alumni Achievement Award in Clinical Science
    American Liver Foundation2000Greater Los Angeles Medical Honoree
    American Gastroenterological Association2005Foundation Research Mentor Award Honoree
    Wadworth VA Alumni Association2006William H. Oldendorf Lifetime Achievement Award
    American Association for the Study of Liver Diseases2006Distinguished Achievement Award
    Western Society of Clinical Investigation2007Mayo Soley Award
    American Liver Foundation2008Distinguished Scientific Achievement Award
    Alpha Omega Alpha
    Phi Beta Kappa

    Collapse Overview 
    Collapse Overview
    Dr. Kaplowitz's research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

    Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.
    Collapse Websites
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    Collapse Research 
    Collapse Research Activities and Funding
    Targets of JNK in acute hepatotoxicity.
    NIH R01DK126866Sep 18, 2020 - May 31, 2025
    Role: Principal Investigator
    Retrograde Signaling in Alcohol-Induced Mitochondrial Stress and Biogenesis.
    NIH R21AA017746Sep 15, 2008 - Aug 31, 2010
    Role: Principal Investigator
    Cellular Mechanisms of Hepatotoxicity.
    NIH R01DK067215Apr 1, 2004 - Feb 28, 2021
    Role: Principal Investigator
    Homocysteine, ER Stress and Alcoholic Liver Injury.
    NIH R01AA014428Jul 1, 2003 - Mar 31, 2015
    Role: Principal Investigator
    USC Research Center for Liver Disease
    NIH P30DK048522Mar 1, 1997 - Feb 28, 2021
    Role: Principal Investigator
    EFFECT OF ETHANOL ON HEPATIC GSH HOMEOSTASIS
    NIH R01AA009526Apr 1, 1993 - Mar 31, 2001
    Role: Principal Investigator
    ROLE OF CYTOKINE INFLAMMATION
    NIH R13DK044465Sep 30, 1991 - Aug 31, 1992
    Role: Principal Investigator
    PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH R01DK030312Feb 1, 1982 - May 31, 2005
    Role: Principal Investigator
    PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH R37DK030312Feb 1, 1982 - May 31, 2000
    Role: Principal Investigator
    THE PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH R01AM030312Feb 1, 1982 - Jan 31, 1987
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity. Hepatology. 2021 Jun 09. Rusyn I, Arzuaga X, Cattley RC, Corton JC, Ferguson SS, Godoy P, Guyton KZ, Kaplowitz N, Khetani SR, Roberts R, Roth RA, Smith MT. PMID: 34105804.
      View in: PubMed   Mentions:    Fields:    
    2. Alcohol, Fasting, and Therapeutic Dosing of Acetaminophen: A Perfect Storm. Hepatology. 2021 May; 73(5):1634-1636. Lee WM, Kaplowitz N. PMID: 33559199.
      View in: PubMed   Mentions:    Fields:    
    3. Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry. J Hepatol. 2021 Jul; 75(1):86-97. Stephens C, Robles-Diaz M, Medina-Caliz I, Garcia-Cortes M, Ortega-Alonso A, Sanabria-Cabrera J, Gonzalez-Jimenez A, Alvarez-Alvarez I, Slim M, Jimenez-Perez M, Gonzalez-Grande R, Fernández MC, Casado M, Soriano G, Román E, Hallal H, Romero-Gomez M, Castiella A, Conde I, Prieto M, Moreno-Planas JM, Giraldez A, Moreno-Sanfiel JM, Kaplowitz N, Lucena MI, Andrade RJ, Participating clinical centres . PMID: 33539847.
      View in: PubMed   Mentions: 2     Fields:    
    4. Clinical Characteristics and Outcome of Drug-Induced Liver Injury in the Older Patients: From the Young-Old to the Oldest-Old. Clin Pharmacol Ther. 2021 Apr; 109(4):1147-1158. Weersink RA, Alvarez-Alvarez I, Medina-Cáliz I, Sanabria-Cabrera J, Robles-Díaz M, Ortega-Alonso A, García-Cortés M, Bonilla E, Niu H, Soriano G, Jimenez-Perez M, Hallal H, Blanco S, Kaplowitz N, Lucena MI, Andrade RJ. PMID: 33179256.
      View in: PubMed   Mentions: 2     Fields:    
    5. REPLY. Hepatol Commun. 2020 Nov; 4(11):1725. Lee BT, Kaplowitz N. PMID: 33163841.
      View in: PubMed   Mentions:
    6. Markedly Elevated Serum Aspartate Aminotransferase to Alanine Aminotransferase Ratio: A Clue to Hepatic Neoplasia. Hepatol Commun. 2020 Jul; 4(7):1099-1101. Lee BT, Chintamaneni K, Kaplowitz N. PMID: 32626840.
      View in: PubMed   Mentions:
    7. Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense. Hepatology. 2020 05; 71(5):1530-1532. Kaplowitz N, Than TA, Win S. PMID: 32065403.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Gut Microbiota and Liver Injury (I)-Acute Liver Injury. Adv Exp Med Biol. 2020; 1238:23-37. Wu G, Win S, Than TA, Chen P, Kaplowitz N. PMID: 32323178.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293. Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N. PMID: 31487267.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis. Clin Gastroenterol Hepatol. 2021 02; 19(2):397-399. Lee BT, Wang Y, Yang A, Han H, Yuan L, Donovan J, Kaplowitz N, Kanel G, Kahn J, Dara L. PMID: 31751773.
      View in: PubMed   Mentions:    Fields:    
    11. Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice. Am J Pathol. 2020 01; 190(1):57-67. Niu M, Luo Z, Gong S, Win S, Kaplowitz N, Jiang Y, Chen P. PMID: 31610172.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Drug-induced liver injury. Nat Rev Dis Primers. 2019 08 22; 5(1):58. Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP. PMID: 31439850.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    13. Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure. Gastroenterology. 2019 08; 157(2):552-568. Torres S, Baulies A, Insausti-Urkia N, Alarcón-Vila C, Fucho R, Solsona-Vilarrasa E, Núñez S, Robles D, Ribas V, Wakefield L, Grompe M, Lucena MI, Andrade RJ, Win S, Aung TA, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. PMID: 31029706.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects. Int J Mol Sci. 2018 Nov 20; 19(11). Win S, Than TA, Kaplowitz N. PMID: 30463289.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. Niacin-Induced Anicteric Microvesicular Steatotic Acute Liver Failure. Hepatol Commun. 2018 Nov; 2(11):1293-1298. Leung K, Quezada M, Chen Z, Kanel G, Kaplowitz N. PMID: 30411075.
      View in: PubMed   Mentions:
    16. Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy. Br J Pharmacol. 2018 10; 175(19):3747-3757. Yan M, Ye L, Yin S, Lu X, Liu X, Lu S, Cui J, Fan L, Kaplowitz N, Hu H. PMID: 30024038.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    17. Herb-Induced Liver Injury: A Global Concern. Chin J Integr Med. 2018 Sep; 24(9):643-644. Kaplowitz N. PMID: 29744785.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases. Hepatology. 2018 05; 67(5):2013-2024. Win S, Than TA, Zhang J, Oo C, Min RWM, Kaplowitz N. PMID: 29194686.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    19. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 07; 69(1):51-59. Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y, Kaplowitz N, Chen P. PMID: 29524531.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    20. Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy. Hepatol Commun. 2017 12; 1(10):1070-1084. Roth NC, Saberi B, Macklin J, Kanel G, French SW, Govindarajan S, Buzzanco AS, Stolz AA, Donovan JA, Kaplowitz N. PMID: 29404443.
      View in: PubMed   Mentions:
    21. Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration? Hepatology. 2017 11; 66(5):1381-1383. Apte U, Kaplowitz N. PMID: 28718936.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol. 2018 04; 14:164-177. Baulies A, Montero J, Matías N, Insausti N, Terrones O, Basañez G, Vallejo C, Conde de La Rosa L, Martinez L, Robles D, Morales A, Abian J, Carrascal M, Machida K, Kumar DBU, Tsukamoto H, Kaplowitz N, Garcia-Ruiz C, Fernández-Checa JC. PMID: 28942194.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    23. Death and liver transplantation within 2 years of onset of drug-induced liver injury. Hepatology. 2017 10; 66(4):1275-1285. Hayashi PH, Rockey DC, Fontana RJ, Tillmann HL, Kaplowitz N, Barnhart HX, Gu J, Chalasani NP, Reddy KR, Sherker AH, Hoofnagle JH, Drug-Induced Liver Injury Network (DILIN) Investigators . PMID: 28543844.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    24. The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell Death Dis. 2017 06 29; 8(6):e2903. Zhang J, Min RWM, Le K, Zhou S, Aghajan M, Than TA, Win S, Kaplowitz N. PMID: 28661486.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    25. Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis. Int J Mol Sci. 2017 May 09; 18(5). Iorga A, Dara L, Kaplowitz N. PMID: 28486401.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    26. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871. Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. PMID: 28330995.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    27. Protective role of p53 in acetaminophen hepatotoxicity. Free Radic Biol Med. 2017 05; 106:111-117. Huo Y, Yin S, Yan M, Win S, Aung Than T, Aghajan M, Hu H, Kaplowitz N. PMID: 28196650.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments. PLoS Comput Biol. 2016 12; 12(12):e1005253. Smith AK, Petersen BK, Ropella GE, Kennedy RC, Kaplowitz N, Ookhtens M, Hunt CA. PMID: 27984590.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    29. Questions and controversies: the role of necroptosis in liver disease. Cell Death Discov. 2016; 2:16089. Dara L, Liu ZX, Kaplowitz N. PMID: 27924226.
      View in: PubMed   Mentions:
    30. Mitochondrial remodeling in the liver following chronic alcohol feeding to rats. Free Radic Biol Med. 2017 01; 102:100-110. Han D, Johnson HS, Rao MP, Martin G, Sancheti H, Silkwood KH, Decker CW, Nguyen KT, Casian JG, Cadenas E, Kaplowitz N. PMID: 27867097.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    31. A murder mystery in the liver: who done it and how? J Clin Invest. 2016 11 01; 126(11):4068-4071. Dara L, Liu ZX, Kaplowitz N. PMID: 27760053.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    32. Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2017 02 10; 26(5):207-220. Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N. PMID: 27596680.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    33. Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-?B. J Immunol. 2016 10 15; 197(8):3120-3129. Suda J, Dara L, Yang L, Aghajan M, Song Y, Kaplowitz N, Liu ZX. PMID: 27605011.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    34. The many faces of RIPK3: What about NASH? Hepatology. 2016 11; 64(5):1411-1413. Dara L, Kaplowitz N. PMID: 27338154.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury. J Hepatol. 2016 09; 65(3):532-42. Medina-Caliz I, Robles-Diaz M, Garcia-Muñoz B, Stephens C, Ortega-Alonso A, Garcia-Cortes M, González-Jimenez A, Sanabria-Cabrera JA, Moreno I, Fernandez MC, Romero-Gomez M, Navarro JM, Barriocanal AM, Montane E, Hallal H, Blanco S, Soriano G, Roman EM, Gómez-Dominguez E, Castiella A, Zapata EM, Jimenez-Perez M, Moreno JM, Aldea-Perona A, Hernández-Guerra M, Prieto M, Zoubek ME, Kaplowitz N, Lucena MI, Andrade RJ, Spanish DILI registry . PMID: 27184533.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    36. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 06; 63(6):1987-2003. Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. PMID: 26845758.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    37. Reply. Hepatology. 2016 07; 64(1):312-3. Dara L, Kaplowitz N. PMID: 26418131.
      View in: PubMed   Mentions:    Fields:    
    38. Alcoholic foamy degeneration and alcoholic fatty liver with jaundice: Often overlooked causes of jaundice and hepatic decompensation that can mimic alcoholic hepatitis. Clin Liver Dis (Hoboken). 2015 Dec; 6(6):145-148. Roth N, Kanel G, Kaplowitz N. PMID: 31041013.
      View in: PubMed   Mentions:
    39. Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy. Sci Rep. 2015 Dec 11; 5:18017. Baulies A, Ribas V, Núñez S, Torres S, Alarcón-Vila C, Martínez L, Suda J, Ybanez MD, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. PMID: 26657973.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    40. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016 Feb; 36(2):158-65. Dara L, Liu ZX, Kaplowitz N. PMID: 26484420.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    41. HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer. Clin Cancer Res. 2016 Mar 15; 22(6):1371-7. Xu CF, Johnson T, Wang X, Carpenter C, Graves AP, Warren L, Xue Z, King KS, Fraser DJ, Stinnett S, Briley LP, Mitrica I, Spraggs CF, Nelson MR, Tada H, du Bois A, Powles T, Kaplowitz N, Pandite LN. PMID: 26546620.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    42. Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database. Drug Saf. 2015 Nov; 38(11):1103-13. Watkins PB, Lewis JH, Kaplowitz N, Alpers DH, Blais JD, Smotzer DM, Krasa H, Ouyang J, Torres VE, Czerwiec FS, Zimmer CA. PMID: 26188764.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    43. Reply. Hepatology. 2016 07; 64(1):308-9. Dara L, Kaplowitz N. PMID: 26390377.
      View in: PubMed   Mentions:    Fields:    
    44. Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, Kaplowitz N. PMID: 26077809.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    45. Inhibition of immune tolerance unmasks drug-induced allergic hepatitis. Hepatology. 2015 Aug; 62(2):346-8. Uetrecht J, Kaplowitz N. PMID: 25833746.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    46. Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients. Eur J Cancer. 2015 Jul; 51(10):1293-302. Powles T, Bracarda S, Chen M, Norry E, Compton N, Heise M, Hutson T, Harter P, Carpenter C, Pandite L, Kaplowitz N. PMID: 25899987.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    47. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. PMID: 25770661.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    48. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N. PMID: 25666017.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    49. Reply: To PMID 24704526. Gastroenterology. 2015 Feb; 148(2):452-3. Robles-Diaz M, Kaplowitz N, Stephens C, Andrade RJ, Lucena MI. PMID: 25532806.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future. Drug Saf. 2014 Nov; 37 Suppl 1:S1-7. Watkins PB, Merz M, Avigan MI, Kaplowitz N, Regev A, Senior JR. PMID: 25352323.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    51. Liver safety assessment in special populations (hepatitis B, C, and oncology trials). Drug Saf. 2014 Nov; 37 Suppl 1:S57-62. Kullak-Ublick GA, Merz M, Griffel L, Kaplowitz N, Watkins PB. PMID: 25352328.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    52. Reply: To PMID 24704526. Gastroenterology. 2014 Dec; 147(6):1442. Robles-Diaz M, Kaplowitz N, Stephens C, Andrade RJ, Lucena MI. PMID: 25449028.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways. J Hepatol. 2015 Jan; 62(1):219-33. Garcia-Ruiz C, Mato JM, Vance D, Kaplowitz N, Fernández-Checa JC. PMID: 25281863.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    54. Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology. 2014 Oct; 147(4):765-783.e4. Luedde T, Kaplowitz N, Schwabe RF. PMID: 25046161.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansAnimalsCells
    55. ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J Hepatol. 2014 Nov; 61(5):1126-34. Fucho R, Martínez L, Baulies A, Torres S, Tarrats N, Fernandez A, Ribas V, Astudillo AM, Balsinde J, Garcia-Rovés P, Elena M, Bergheim I, Lotersztajn S, Trautwein C, Appelqvist H, Paton AW, Paton JC, Czaja MJ, Kaplowitz N, Fernandez-Checa JC, García-Ruiz C. PMID: 24946279.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    56. Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway. Chem Res Toxicol. 2014 May 19; 27(5):794-804. Chang AH, Sancheti H, Garcia J, Kaplowitz N, Cadenas E, Han D. PMID: 24716714.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    57. Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury. Gastroenterology. 2014 Jul; 147(1):109-118.e5. Robles-Diaz M, Lucena MI, Kaplowitz N, Stephens C, Medina-Cáliz I, González-Jimenez A, Ulzurrun E, Gonzalez AF, Fernandez MC, Romero-Gómez M, Jimenez-Perez M, Bruguera M, Prieto M, Bessone F, Hernandez N, Arrese M, Andrade RJ, Spanish DILI Registry , SLatinDILI Network , Safer and Faster Evidence-based Translation Consortium . PMID: 24704526.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    58. Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways. Hepatology. 2014 Apr; 59(4):1543-1554. Saberi B, Ybanez MD, Johnson HS, Gaarde WA, Han D, Kaplowitz N. PMID: 23873604.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    59. Role of Mitochondria in Alcoholic Liver Disease. Curr Pathobiol Rep. 2013 Sep 01; 1(3):159-168. García-Ruiz C, Kaplowitz N, Fernandez-Checa JC. PMID: 25343061.
      View in: PubMed   Mentions:
    60. Mechanisms of drug-induced liver injury. Clin Liver Dis. 2013 Nov; 17(4):507-18, vii. Yuan L, Kaplowitz N. PMID: 24099014.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    61. Avoiding idiosyncratic DILI: two is better than one. Hepatology. 2013 Jul; 58(1):15-7. Kaplowitz N. PMID: 23390057.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    62. ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol. 2013 Oct; 59(4):805-13. Fernandez A, Matias N, Fucho R, Ribas V, Von Montfort C, Nuño N, Baulies A, Martinez L, Tarrats N, Mari M, Colell A, Morales A, Dubuquoy L, Mathurin P, Bataller R, Caballeria J, Elena M, Balsinde J, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. PMID: 23707365.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    63. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. PMID: 23453390.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    64. Current challenges and controversies in drug-induced liver injury. Drug Saf. 2012 Dec 01; 35(12):1099-117. Corsini A, Ganey P, Ju C, Kaplowitz N, Pessayre D, Roth R, Watkins PB, Albassam M, Liu B, Stancic S, Suter L, Bortolini M. PMID: 23137150.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    65. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; 1830(5):3317-28. Marí M, Morales A, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. PMID: 23123815.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    66. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 07; 287(50):42165-79. Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. PMID: 23086958.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    67. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9. von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. PMID: 22687340.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    68. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul; 56(1):130-9. Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. PMID: 22307928.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    69. Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling. J Chromatogr A. 2012 Oct 12; 1259:128-37. Gika HG, Ji C, Theodoridis GA, Michopoulos F, Kaplowitz N, Wilson ID. PMID: 22446076.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    70. Dealing with stress. Hepatology. 2012 Jan; 55(1):3-13. Kaplowitz N. PMID: 22135222.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    71. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 07; 286(40):35071-8. Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. PMID: 21844199.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    72. Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology. 2011 Jul; 54(1):229-39. Ji C, Kaplowitz N, Lau MY, Kao E, Petrovic LM, Lee AS. PMID: 21503947.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    73. Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. Pharmacogenet Genomics. 2011 Jul; 21(7):365-74. Lee JS, Wang J, Martin M, Germer S, Kenwright A, Benayed R, Spleiss O, Platt A, Pilson R, Hemmings A, Weinblatt ME, Kaplowitz N, Krasnow J. PMID: 21412181.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    74. Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. Than TA, Lou H, Ji C, Win S, Kaplowitz N. PMID: 21536665.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    75. The contribution of endoplasmic reticulum stress to liver diseases. Hepatology. 2011 May; 53(5):1752-63. Dara L, Ji C, Kaplowitz N. PMID: 21384408.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    76. Differential effect of gender on hepatic fat. Pediatr Radiol. 2011 Sep; 41(9):1146-53. Gilsanz V, Chung SA, Kaplowitz N. PMID: 21404026.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    77. Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. J Proteome Res. 2011 Feb 04; 10(2):705-13. Loftus N, Barnes A, Ashton S, Michopoulos F, Theodoridis G, Wilson I, Ji C, Kaplowitz N. PMID: 21028815.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    78. Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem. 2010 Dec 17; 285(51):39646-54. Garcia J, Han D, Sancheti H, Yap LP, Kaplowitz N, Cadenas E. PMID: 20937819.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    79. Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv. 2010 Apr; 10(2):98-111. Jones DP, Lemasters JJ, Han D, Boelsterli UA, Kaplowitz N. PMID: 20368370.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    80. Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology. 2010 Mar; 51(3):796-805. Shinohara M, Ji C, Kaplowitz N. PMID: 20069651.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    81. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N. PMID: 20061376.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    82. Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol. 2010; (196):267-310. Han D, Shinohara M, Ybanez MD, Saberi B, Kaplowitz N. PMID: 20020266.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    83. Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal. 2009 Sep; 11(9):2245-63. Han D, Ybanez MD, Ahmadi S, Yeh K, Kaplowitz N. PMID: 19361274.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    84. Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology. 2009 Jun; 49(6):2001-9. Lucena MI, Andrade RJ, Kaplowitz N, García-Cortes M, Fernández MC, Romero-Gomez M, Bruguera M, Hallal H, Robles-Diaz M, Rodriguez-González JF, Navarro JM, Salmeron J, Martinez-Odriozola P, Pérez-Alvarez R, Borraz Y, Hidalgo R, Spanish Group for the Study of Drug-Induced Liver Disease . PMID: 19475693.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    85. Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease. Am J Respir Crit Care Med. 2009 May 01; 179(9):835-42. Roberts KE, Fallon MB, Krowka MJ, Brown RS, Trotter JF, Peter I, Tighiouart H, Knowles JA, Rabinowitz D, Benza RL, Badesch DB, Taichman DB, Horn EM, Zacks S, Kaplowitz N, Kawut SM, Pulmonary Vascular Complications of Liver Disease Study Group . PMID: 19218192.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    86. How to protect against acetaminophen: don't ask for JUNK. Gastroenterology. 2008 Oct; 135(4):1047-51. Kaplowitz N, Shinohara M, Liu ZX, Han D. PMID: 18782575.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    87. Glutathione in liver diseases and hepatotoxicity. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):29-41. Yuan L, Kaplowitz N. PMID: 18786561.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    88. Clinical risk factors for portopulmonary hypertension. Hepatology. 2008 Jul; 48(1):196-203. Kawut SM, Krowka MJ, Trotter JF, Roberts KE, Benza RL, Badesch DB, Taichman DB, Horn EM, Zacks S, Kaplowitz N, Brown RS, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group . PMID: 18537192.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    89. Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology. 2008 Oct; 135(4):1168-75. Fallon MB, Krowka MJ, Brown RS, Trotter JF, Zacks S, Roberts KE, Shah VH, Kaplowitz N, Forman L, Wille K, Kawut SM, Pulmonary Vascular Complications of Liver Disease Study Group . PMID: 18644373.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    90. Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. Ji C, Shinohara M, Vance D, Than TA, Ookhtens M, Chan C, Kaplowitz N. PMID: 18498552.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    91. Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. . 2008 Jul; 295(1):C50-63. Saberi B, Shinohara M, Ybanez MD, Hanawa N, Gaarde WA, Kaplowitz N, Han D. PMID: 18463227.
      View in: PubMed   Mentions:
    92. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem. 2008 May 16; 283(20):13565-77. Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N. PMID: 18337250.
      View in: PubMed   Mentions: 225     Fields:    Translation:AnimalsCells
    93. Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology. 2007 Nov; 46(5):1586-96. Ji C, Shinohara M, Kuhlenkamp J, Chan C, Kaplowitz N. PMID: 17705221.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    94. Endoplasmic reticulum stress and liver injury. Semin Liver Dis. 2007 Nov; 27(4):367-77. Kaplowitz N, Than TA, Shinohara M, Ji C. PMID: 17979073.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    95. Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem. 2007 Oct 05; 282(40):29470-81. Lou H, Kaplowitz N. PMID: 17690092.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    96. Mechanisms of drug-induced liver disease. Clin Liver Dis. 2007 Aug; 11(3):459-75, v. Gunawan BK, Kaplowitz N. PMID: 17723915.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    97. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr. 2007 Jul; 86(1):14-24. Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, Kharbanda KK, Liu QY, Lu SC, McClain CJ, Swanson C, Zakhari S. PMID: 17616758.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    98. Drug-induced liver injury. Drug Saf. 2007; 30(4):277-94. Abboud G, Kaplowitz N. PMID: 17408305.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    99. Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology. 2006 Dec; 44(6):1581-8. Andrade RJ, Lucena MI, Kaplowitz N, García-Munoz B, Borraz Y, Pachkoria K, García-Cortés M, Fernández MC, Pelaez G, Rodrigo L, Durán JA, Costa J, Planas R, Barriocanal A, Guarner C, Romero-Gomez M, Munoz-Yagüe T, Salmerón J, Hidalgo R. PMID: 17133470.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    100. Current concepts and controversies in the treatment of alcoholic hepatitis. World J Gastroenterol. 2006 Nov 21; 12(43):6909-21. Rongey C, Kaplowitz N. PMID: 17109510.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    101. Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S7-9. Kaplowitz N, Ji C. PMID: 16958678.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    102. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. Liu ZX, Kaplowitz N. PMID: 16859400.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    103. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA. 2006 Jul 05; 296(1):87-93. Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC. PMID: 16820551.
      View in: PubMed   Mentions: 116     Fields:    Translation:Humans
    104. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006 Jul; 131(1):165-78. Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. PMID: 16831600.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    105. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol. 2006 Nov; 45(5):717-24. Ji C, Chan C, Kaplowitz N. PMID: 16879892.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    106. ER stress: can the liver cope? J Hepatol. 2006 Aug; 45(2):321-33. Ji C, Kaplowitz N. PMID: 16797772.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    107. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology. 2006 Jun; 43(6):1220-30. Liu ZX, Han D, Gunawan B, Kaplowitz N. PMID: 16729305.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    108. Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med. 2006 Aug 15; 41(4):627-39. Han D, Hanawa N, Saberi B, Kaplowitz N. PMID: 16863996.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    109. Drug hepatotoxicity. Clin Liver Dis. 2006 May; 10(2):207-17, vii. Nathwani RA, Kaplowitz N. PMID: 16971258.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    110. Rules and laws of drug hepatotoxicity. Pharmacoepidemiol Drug Saf. 2006 Apr; 15(4):231-3. Kaplowitz N. PMID: 16552791.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    111. Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G1-7. Han D, Hanawa N, Saberi B, Kaplowitz N. PMID: 16500922.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    112. Liver biology and pathobiology. Hepatology. 2006 Feb; 43(2 Suppl 1):S235-8. Kaplowitz N. PMID: 16447293.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    113. Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res. 2005 Aug; 29(8):1496-503. Ji C, Mehrian-Shai R, Chan C, Hsu YH, Kaplowitz N. PMID: 16131858.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    114. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov. 2005 Jun; 4(6):489-99. Kaplowitz N. PMID: 15931258.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimals
    115. Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol. 2005 May 01; 204(3):263-73. Fernandez-Checa JC, Kaplowitz N. PMID: 15845418.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    116. Serum alanine aminotransferase in skeletal muscle diseases. Hepatology. 2005 Feb; 41(2):380-2. Nathwani RA, Pais S, Reynolds TB, Kaplowitz N. PMID: 15660433.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    117. Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. Am J Gastroenterol. 2005 Feb; 100(2):295-8. Nathwani RA, Kumar SR, Reynolds TB, Kaplowitz N. PMID: 15667485.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    118. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004 Dec; 127(6):1760-74. Liu ZX, Govindarajan S, Kaplowitz N. PMID: 15578514.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    119. Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol. 2004 Dec; 41(6):1062-4. Neff GW, Reddy KR, Durazo FA, Meyer D, Marrero R, Kaplowitz N. PMID: 15582145.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    120. Statin-induced hepatotoxicity. Gastroenterology. 2004 Oct; 127(4):1278; author reply 1278-9. Kaplowitz N. PMID: 15481021.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    121. Liver injury associated with the beta-interferons for MS. Neurology. 2004 Sep 28; 63(6):1142-3; author reply 1142-3. Francis GS, Kaplowitz N, Alteri E. PMID: 15457586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    122. Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology. 2004 Aug; 40(2):442-51. Ji C, Deng Q, Kaplowitz N. PMID: 15368449.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    123. Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology. 2004 Jul; 40(1):23-6. Kaplowitz N. PMID: 15239082.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    124. Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J Gastroenterol. 2004 Jun 15; 10(12):1699-708. Ji C, Kaplowitz N. PMID: 15188490.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    125. Clinical perspectives on xenobiotic-induced hepatotoxicity. Drug Metab Rev. 2004 May; 36(2):301-12. Gunawan B, Kaplowitz N. PMID: 15237856.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    126. Drug-induced liver injury. Clin Infect Dis. 2004 Mar 01; 38 Suppl 2:S44-8. Kaplowitz N. PMID: 14986274.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    127. Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochem Pharmacol. 2004 Feb 01; 67(3):439-51. Han D, Matsumaru K, Rettori D, Kaplowitz N. PMID: 15037196.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    128. Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria. Mol Pharmacol. 2003 Nov; 64(5):1136-44. Han D, Canali R, Rettori D, Kaplowitz N. PMID: 14573763.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    129. Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology. 2003 Sep; 38(3):692-702. Coll O, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. PMID: 12939596.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    130. Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. Lou H, Ookhtens M, Stolz A, Kaplowitz N. PMID: 12893631.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    131. Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology. 2003 Jun; 37(6):1425-34. Matsumaru K, Ji C, Kaplowitz N. PMID: 12774022.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    132. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May; 124(5):1488-99. Ji C, Kaplowitz N. PMID: 12730887.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    133. Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology. 2003 Mar; 124(3):708-24. Lluis JM, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. PMID: 12612910.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    134. Did this drug cause my patient's hepatitis? Ann Intern Med. 2003 Jan 21; 138(2):159-60; author reply 159-60. Kaplowitz N, Lewis JH, Watkins PB. PMID: 12529106.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    135. Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance. Drug Saf. 2003; 26(11):815-27. Francis GS, Grumser Y, Alteri E, Micaleff A, O'Brien F, Alsop J, Stam Moraga M, Kaplowitz N. PMID: 12908850.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCTClinical Trials
    136. Immune-mediated drug-induced liver disease. Clin Liver Dis. 2002 Aug; 6(3):755-74. Liu ZX, Kaplowitz N. PMID: 12362579.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    137. Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology. 2002 Jul; 36(1):55-64. Nagai H, Matsumaru K, Feng G, Kaplowitz N. PMID: 12085349.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    138. Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G825-34. Feng G, Kaplowitz N. PMID: 11960779.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    139. The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol. 2002 Feb; 61(2):425-35. Mittur A, Wolkoff AW, Kaplowitz N. PMID: 11809868.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    140. Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis. 2002; 22(2):137-44. Kaplowitz N. PMID: 12016545.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
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