Neil Kaplowitz, MD

Title(s)Professor of Medicine
SchoolKeck School of Medicine of Usc
AddressHMR 101
Health Sciences Campus
Los Angeles CA 90089-9091
Phone+1 323 442 5576
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    Other Positions
    Title(s)USC Associates/Thomas H. Brem Chair in Medicine


    Collapse Biography 
    Collapse Awards and Honors
    Western Gastroenterology 1986Research Prize
    Association of American Physicians1988Member
    NIH1992Merit Award
    Department of Veterans Affairs 1993William S. Middleton Award
    New York University School of Medicine1994Solomon A. Berson Medical Alumni Achievement Award in Clinical Science
    American Liver Foundation2000Greater Los Angeles Medical Honoree
    American Gastroenterological Association2005Foundation Research Mentor Award Honoree
    Wadworth VA Alumni Association2006William H. Oldendorf Lifetime Achievement Award
    American Association for the Study of Liver Diseases2006Distinguished Achievement Award
    Western Society of Clinical Investigation2007Mayo Soley Award
    American Liver Foundation2008Distinguished Scientific Achievement Award
    Alpha Omega Alpha
    Phi Beta Kappa

    Collapse Overview 
    Collapse Overview
    Dr. Kaplowitz's research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

    Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.
    Collapse Websites
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    Collapse Research 
    Collapse Research Activities and Funding
    Targets of JNK in acute hepatotoxicity.
    NIH R01DK126866Sep 18, 2020 - May 31, 2025
    Role: Principal Investigator
    Retrograde Signaling in Alcohol-Induced Mitochondrial Stress and Biogenesis.
    NIH R21AA017746Sep 15, 2008 - Aug 31, 2010
    Role: Principal Investigator
    Cellular Mechanisms of Hepatotoxicity.
    NIH R01DK067215Apr 1, 2004 - Feb 28, 2021
    Role: Principal Investigator
    Homocysteine, ER Stress and Alcoholic Liver Injury.
    NIH R01AA014428Jul 1, 2003 - Mar 31, 2015
    Role: Principal Investigator
    USC Research Center for Liver Disease
    NIH P30DK048522Mar 1, 1995 - Feb 28, 2021
    Role: Principal Investigator
    EFFECT OF ETHANOL ON HEPATIC GSH HOMEOSTASIS
    NIH R01AA009526Apr 1, 1993 - Mar 31, 2001
    Role: Principal Investigator
    ROLE OF CYTOKINE INFLAMMATION
    NIH R13DK044465Sep 30, 1991 - Aug 31, 1992
    Role: Principal Investigator
    PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH R01DK030312Feb 1, 1982 - May 31, 2005
    Role: Principal Investigator
    PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH R37DK030312Feb 1, 1982 - May 31, 2000
    Role: Principal Investigator
    THE PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH R01AM030312Feb 1, 1982 - Jan 31, 1987
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding. Neurobiol Dis. 2024 Sep; 199:106570. Chandrashekar DV, Roules GC, Jagadeesan N, Panchal UR, Oyegbesan A, Imiruaye OE, Zhang H, Garcia J, Kaur K, Win S, Than TA, Kaplowitz N, Roosan MR, Han D, Sumbria RK. PMID: 38885850.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death. Front Cell Dev Biol. 2024; 12:1359152. Win S, Than TA, Kaplowitz N. PMID: 38559813; PMCID: PMC10978662.
      View in: PubMed   Mentions: 1  
    3. Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism. Cell Host Microbe. 2024 Jan 10; 32(1):48-62.e9. Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, Zhang X, Wei R, Zeng Y, Zheng H, Chen B, Xiong Q, Xue T, Guan T, Guo J, Tian Y, Zeng LY, Liu Z, Yuan H, Yang L, Liu H, Dai L, Yu Y, Qiu Y, Wu P, Win S, Than TA, Wei R, Schnabl B, Kaplowitz N, Jiang Y, Ma Q, Chen P. PMID: 38056458.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    4. Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries. Liver Int. 2023 08; 43(8):1749-1760. García-Cortés M, Ortega-Alonso A, Matilla-Cabello G, Medina-Cáliz I, Castiella A, Conde I, Bonilla-Toyos E, Pinazo-Bandera J, Hernández N, Tagle M, Nunes V, Parana R, Bessone F, Kaplowitz N, Lucena MI, Alvarez-Alvarez I, Robles-Díaz M, Andrade RJ. PMID: 37269163.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. c-Jun-N Terminal Kinase-Mediated Degradation of γ-Glutamylcysteine Ligase Catalytic Subunit Inhibits GSH Recovery After Acetaminophen Treatment: Role in Sustaining JNK Activation and Liver Injury. Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081. Win S, Than TA, Kaplowitz N. PMID: 36333933; PMCID: PMC10425160.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-β. Front Physiol. 2022; 13:930402. Garcia J, Chang R, Steinberg RA, Arce A, Yang J, Van Der Eb P, Abdullah T, Chandrashekar DV, Eck SM, Meza P, Liu ZX, Cadenas E, Cribbs DH, Kaplowitz N, Sumbria RK, Han D. PMID: 36187787; PMCID: PMC9520570.
      View in: PubMed   Mentions: 7  
    7. Endoplasmic reticulum stress in liver diseases. Hepatology. 2023 02 01; 77(2):619-639. Ajoolabady A, Kaplowitz N, Lebeaupin C, Kroemer G, Kaufman RJ, Malhi H, Ren J. PMID: 35524448; PMCID: PMC9637239.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    8. Introducing Laurie DeLeve, M.D., Ph.D., Our 2022 AASLD President. Hepatology. 2022 03; 75(3):514-517. Kaplowitz N. PMID: 34866210.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Hepatology. 2021 12; 74(6):3127-3145. Win S, Min RWM, Zhang J, Kanel G, Wanken B, Chen Y, Li M, Wang Y, Suzuki A, Aung FWM, Murray SF, Aghajan M, Than TA, Kaplowitz N. PMID: 34331779; PMCID: PMC8639630.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    10. Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity. Hepatology. 2021 12; 74(6):3486-3496. Rusyn I, Arzuaga X, Cattley RC, Corton JC, Ferguson SS, Godoy P, Guyton KZ, Kaplowitz N, Khetani SR, Roberts RA, Roth RA, Smith MT. PMID: 34105804; PMCID: PMC8901129.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    11. The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice. Acta Pharm Sin B. 2022 Jan; 12(1):182-196. Li R, Xie L, Li L, Chen X, Yao T, Tian Y, Li Q, Wang K, Huang C, Li C, Li Y, Zhou H, Kaplowitz N, Jiang Y, Chen P. PMID: 35127379; PMCID: PMC8799880.
      View in: PubMed   Mentions: 17  
    12. Alcohol, Fasting, and Therapeutic Dosing of Acetaminophen: A Perfect Storm. Hepatology. 2021 05; 73(5):1634-1636. Lee WM, Kaplowitz N. PMID: 33559199.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    13. Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry. J Hepatol. 2021 07; 75(1):86-97. Stephens C, Robles-Diaz M, Medina-Caliz I, Garcia-Cortes M, Ortega-Alonso A, Sanabria-Cabrera J, Gonzalez-Jimenez A, Alvarez-Alvarez I, Slim M, Jimenez-Perez M, Gonzalez-Grande R, Fernández MC, Casado M, Soriano G, Román E, Hallal H, Romero-Gomez M, Castiella A, Conde I, Prieto M, Moreno-Planas JM, Giraldez A, Moreno-Sanfiel JM, Kaplowitz N, Lucena MI, Andrade RJ, Participating clinical centres. PMID: 33539847.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    14. Clinical Characteristics and Outcome of Drug-Induced Liver Injury in the Older Patients: From the Young-Old to the Oldest-Old. Clin Pharmacol Ther. 2021 04; 109(4):1147-1158. Weersink RA, Alvarez-Alvarez I, Medina-Cáliz I, Sanabria-Cabrera J, Robles-Díaz M, Ortega-Alonso A, García-Cortés M, Bonilla E, Niu H, Soriano G, Jimenez-Perez M, Hallal H, Blanco S, Kaplowitz N, Lucena MI, Andrade RJ. PMID: 33179256.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    15. REPLY. Hepatol Commun. 2020 Nov; 4(11):1725. Lee BT, Kaplowitz N. PMID: 33163841; PMCID: PMC7603530.
      View in: PubMed   Mentions:    Fields:    
    16. Markedly Elevated Serum Aspartate Aminotransferase to Alanine Aminotransferase Ratio: A Clue to Hepatic Neoplasia. Hepatol Commun. 2020 Jul; 4(7):1099-1101. Lee BT, Chintamaneni K, Kaplowitz N. PMID: 32626840; PMCID: PMC7327204.
      View in: PubMed   Mentions:    Fields:    
    17. Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense. Hepatology. 2020 05; 71(5):1530-1532. Kaplowitz N, Than TA, Win S. PMID: 32065403.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    18. Gut Microbiota and Liver Injury (I)-Acute Liver Injury. Adv Exp Med Biol. 2020; 1238:23-37. Wu G, Win S, Than TA, Chen P, Kaplowitz N. PMID: 32323178.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293. Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N. PMID: 31487267; PMCID: PMC6877311.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    20. IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis. Clin Gastroenterol Hepatol. 2021 02; 19(2):397-399. Lee BT, Wang Y, Yang A, Han H, Yuan L, Donovan J, Kaplowitz N, Kanel G, Kahn J, Dara L. PMID: 31751773; PMCID: PMC7231645.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    21. Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice. Am J Pathol. 2020 01; 190(1):57-67. Niu M, Luo Z, Gong S, Win S, Kaplowitz N, Jiang Y, Chen P. PMID: 31610172; PMCID: PMC6943379.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Drug-induced liver injury. Nat Rev Dis Primers. 2019 08 22; 5(1):58. Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP. PMID: 31439850.
      View in: PubMed   Mentions: 206     Fields:    Translation:Humans
    23. Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure. Gastroenterology. 2019 08; 157(2):552-568. Torres S, Baulies A, Insausti-Urkia N, Alarcón-Vila C, Fucho R, Solsona-Vilarrasa E, Núñez S, Robles D, Ribas V, Wakefield L, Grompe M, Lucena MI, Andrade RJ, Win S, Aung TA, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. PMID: 31029706.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    24. The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects. Int J Mol Sci. 2018 Nov 20; 19(11). Win S, Than TA, Kaplowitz N. PMID: 30463289; PMCID: PMC6274687.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    25. Niacin-Induced Anicteric Microvesicular Steatotic Acute Liver Failure. Hepatol Commun. 2018 Nov; 2(11):1293-1298. Leung K, Quezada M, Chen Z, Kanel G, Kaplowitz N. PMID: 30411075; PMCID: PMC6211325.
      View in: PubMed   Mentions: 8     Fields:    
    26. Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy. Br J Pharmacol. 2018 10; 175(19):3747-3757. Yan M, Ye L, Yin S, Lu X, Liu X, Lu S, Cui J, Fan L, Kaplowitz N, Hu H. PMID: 30024038; PMCID: PMC6135785.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    27. Herb-Induced Liver Injury: A Global Concern. Chin J Integr Med. 2018 Sep; 24(9):643-644. Kaplowitz N. PMID: 29744785.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    28. New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases. Hepatology. 2018 05; 67(5):2013-2024. Win S, Than TA, Zhang J, Oo C, Min RWM, Kaplowitz N. PMID: 29194686; PMCID: PMC5906137.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    29. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 07; 69(1):51-59. Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y, Kaplowitz N, Chen P. PMID: 29524531; PMCID: PMC6365016.
      View in: PubMed   Mentions: 111     Fields:    Translation:Animals
    30. Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy. Hepatol Commun. 2017 12; 1(10):1070-1084. Roth NC, Saberi B, Macklin J, Kanel G, French SW, Govindarajan S, Buzzanco AS, Stolz AA, Donovan JA, Kaplowitz N. PMID: 29404443; PMCID: PMC5721404.
      View in: PubMed   Mentions: 9     Fields:    
    31. Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration? Hepatology. 2017 11; 66(5):1381-1383. Apte U, Kaplowitz N. PMID: 28718936; PMCID: PMC5841241.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol. 2018 04; 14:164-177. Baulies A, Montero J, Matías N, Insausti N, Terrones O, Basañez G, Vallejo C, Conde de La Rosa L, Martinez L, Robles D, Morales A, Abian J, Carrascal M, Machida K, Kumar DBU, Tsukamoto H, Kaplowitz N, Garcia-Ruiz C, Fernández-Checa JC. PMID: 28942194; PMCID: PMC5609874.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    33. Death and liver transplantation within 2 years of onset of drug-induced liver injury. Hepatology. 2017 10; 66(4):1275-1285. Hayashi PH, Rockey DC, Fontana RJ, Tillmann HL, Kaplowitz N, Barnhart HX, Gu J, Chalasani NP, Reddy KR, Sherker AH, Hoofnagle JH, Drug-Induced Liver Injury Network (DILIN) Investigators. PMID: 28543844; PMCID: PMC5605419.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    34. The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell Death Dis. 2017 06 29; 8(6):e2903. Zhang J, Min RWM, Le K, Zhou S, Aghajan M, Than TA, Win S, Kaplowitz N. PMID: 28661486; PMCID: PMC5584575.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    35. Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis. Int J Mol Sci. 2017 May 09; 18(5). Iorga A, Dara L, Kaplowitz N. PMID: 28486401; PMCID: PMC5454931.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    36. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871. Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. PMID: 28330995; PMCID: PMC5389309.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    37. Protective role of p53 in acetaminophen hepatotoxicity. Free Radic Biol Med. 2017 05; 106:111-117. Huo Y, Yin S, Yan M, Win S, Aung Than T, Aghajan M, Hu H, Kaplowitz N. PMID: 28196650; PMCID: PMC5396540.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    38. Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments. PLoS Comput Biol. 2016 12; 12(12):e1005253. Smith AK, Petersen BK, Ropella GE, Kennedy RC, Kaplowitz N, Ookhtens M, Hunt CA. PMID: 27984590; PMCID: PMC5161305.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    39. Questions and controversies: the role of necroptosis in liver disease. Cell Death Discov. 2016; 2:16089. Dara L, Liu ZX, Kaplowitz N. PMID: 27924226; PMCID: PMC5136616.
      View in: PubMed   Mentions: 52  
    40. Mitochondrial remodeling in the liver following chronic alcohol feeding to rats. Free Radic Biol Med. 2017 01; 102:100-110. Han D, Johnson HS, Rao MP, Martin G, Sancheti H, Silkwood KH, Decker CW, Nguyen KT, Casian JG, Cadenas E, Kaplowitz N. PMID: 27867097; PMCID: PMC5209270.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    41. A murder mystery in the liver: who done it and how? J Clin Invest. 2016 11 01; 126(11):4068-4071. Dara L, Liu ZX, Kaplowitz N. PMID: 27760053; PMCID: PMC5096892.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    42. Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2017 02 10; 26(5):207-220. Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N. PMID: 27596680; PMCID: PMC5312552.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    43. Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB. J Immunol. 2016 10 15; 197(8):3120-3129. Suda J, Dara L, Yang L, Aghajan M, Song Y, Kaplowitz N, Liu ZX. PMID: 27605011; PMCID: PMC5101131.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    44. The many faces of RIPK3: What about NASH? Hepatology. 2016 11; 64(5):1411-1413. Dara L, Kaplowitz N. PMID: 27338154; PMCID: PMC5074903.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    45. Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury. J Hepatol. 2016 09; 65(3):532-42. Medina-Caliz I, Robles-Diaz M, Garcia-Muñoz B, Stephens C, Ortega-Alonso A, Garcia-Cortes M, González-Jimenez A, Sanabria-Cabrera JA, Moreno I, Fernandez MC, Romero-Gomez M, Navarro JM, Barriocanal AM, Montane E, Hallal H, Blanco S, Soriano G, Roman EM, Gómez-Dominguez E, Castiella A, Zapata EM, Jimenez-Perez M, Moreno JM, Aldea-Perona A, Hernández-Guerra M, Prieto M, Zoubek ME, Kaplowitz N, Lucena MI, Andrade RJ, Spanish DILI registry. PMID: 27184533; PMCID: PMC7458366.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    46. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 06; 63(6):1987-2003. Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. PMID: 26845758; PMCID: PMC4874901.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    47. Reply. Hepatology. 2016 07; 64(1):312-3. Dara L, Kaplowitz N. PMID: 26418131.
      View in: PubMed   Mentions:    Fields:    
    48. Alcoholic foamy degeneration and alcoholic fatty liver with jaundice: Often overlooked causes of jaundice and hepatic decompensation that can mimic alcoholic hepatitis. Clin Liver Dis (Hoboken). 2015 Dec; 6(6):145-148. Roth N, Kanel G, Kaplowitz N. PMID: 31041013; PMCID: PMC6490664.
      View in: PubMed   Mentions: 3  
    49. Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy. Sci Rep. 2015 Dec 11; 5:18017. Baulies A, Ribas V, Núñez S, Torres S, Alarcón-Vila C, Martínez L, Suda J, Ybanez MD, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. PMID: 26657973; PMCID: PMC4676017.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    50. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016 Feb; 36(2):158-65. Dara L, Liu ZX, Kaplowitz N. PMID: 26484420; PMCID: PMC4718752.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    51. HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer. Clin Cancer Res. 2016 Mar 15; 22(6):1371-7. Xu CF, Johnson T, Wang X, Carpenter C, Graves AP, Warren L, Xue Z, King KS, Fraser DJ, Stinnett S, Briley LP, Mitrica I, Spraggs CF, Nelson MR, Tada H, du Bois A, Powles T, Kaplowitz N, Pandite LN. PMID: 26546620; PMCID: PMC7444994.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    52. Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database. Drug Saf. 2015 Nov; 38(11):1103-13. Watkins PB, Lewis JH, Kaplowitz N, Alpers DH, Blais JD, Smotzer DM, Krasa H, Ouyang J, Torres VE, Czerwiec FS, Zimmer CA. PMID: 26188764; PMCID: PMC4608984.
      View in: PubMed   Mentions: 97     Fields:    Translation:Humans
    53. Reply. Hepatology. 2016 07; 64(1):308-9. Dara L, Kaplowitz N. PMID: 26390377.
      View in: PubMed   Mentions:    Fields:    
    54. Is Sensitivity the Key Measure to Predict Acute Liver Failure in Drug-Induced Liver Injury Patients? Clin Gastroenterol Hepatol. 2016 06; 14(6):918. Robles-Diaz M, Andrade RJ, Kaplowitz N. PMID: 26460215.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, Kaplowitz N. PMID: 26077809; PMCID: PMC4681652.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    56. Inhibition of immune tolerance unmasks drug-induced allergic hepatitis. Hepatology. 2015 Aug; 62(2):346-8. Uetrecht J, Kaplowitz N. PMID: 25833746.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    57. Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients. Eur J Cancer. 2015 Jul; 51(10):1293-302. Powles T, Bracarda S, Chen M, Norry E, Compton N, Heise M, Hutson T, Harter P, Carpenter C, Pandite L, Kaplowitz N. PMID: 25899987; PMCID: PMC7451810.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    58. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. PMID: 25770661.
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    59. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N. PMID: 25666017; PMCID: PMC4439305.
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    60. Reply: To PMID 24704526. Gastroenterology. 2015 Feb; 148(2):452-3. Robles-Diaz M, Kaplowitz N, Stephens C, Andrade RJ, Lucena MI. PMID: 25532806.
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    61. The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future. Drug Saf. 2014 Nov; 37 Suppl 1:S1-7. Watkins PB, Merz M, Avigan MI, Kaplowitz N, Regev A, Senior JR. PMID: 25352323; PMCID: PMC4212148.
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    62. Liver safety assessment in special populations (hepatitis B, C, and oncology trials). Drug Saf. 2014 Nov; 37 Suppl 1:S57-62. Kullak-Ublick GA, Merz M, Griffel L, Kaplowitz N, Watkins PB. PMID: 25352328; PMCID: PMC4212149.
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    63. Reply: To PMID 24704526. Gastroenterology. 2014 Dec; 147(6):1442. Robles-Diaz M, Kaplowitz N, Stephens C, Andrade RJ, Lucena MI. PMID: 25449028.
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    64. Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways. J Hepatol. 2015 Jan; 62(1):219-33. Garcia-Ruiz C, Mato JM, Vance D, Kaplowitz N, Fernández-Checa JC. PMID: 25281863.
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    65. In vitro assays of mitochondrial function/dysfunction. Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. Than TA, Win S, Kaplowitz N. PMID: 25207701.
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    66. Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology. 2014 Oct; 147(4):765-783.e4. Luedde T, Kaplowitz N, Schwabe RF. PMID: 25046161; PMCID: PMC4531834.
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    67. ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J Hepatol. 2014 Nov; 61(5):1126-34. Fucho R, Martínez L, Baulies A, Torres S, Tarrats N, Fernandez A, Ribas V, Astudillo AM, Balsinde J, Garcia-Rovés P, Elena M, Bergheim I, Lotersztajn S, Trautwein C, Appelqvist H, Paton AW, Paton JC, Czaja MJ, Kaplowitz N, Fernandez-Checa JC, García-Ruiz C. PMID: 24946279; PMCID: PMC4203709.
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    68. Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway. Chem Res Toxicol. 2014 May 19; 27(5):794-804. Chang AH, Sancheti H, Garcia J, Kaplowitz N, Cadenas E, Han D. PMID: 24716714; PMCID: PMC4033640.
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    69. Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury. Gastroenterology. 2014 Jul; 147(1):109-118.e5. Robles-Diaz M, Lucena MI, Kaplowitz N, Stephens C, Medina-Cáliz I, González-Jimenez A, Ulzurrun E, Gonzalez AF, Fernandez MC, Romero-Gómez M, Jimenez-Perez M, Bruguera M, Prieto M, Bessone F, Hernandez N, Arrese M, Andrade RJ, Spanish DILI Registry, SLatinDILI Network, Safer and Faster Evidence-based Translation Consortium. PMID: 24704526.
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    70. Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways. Hepatology. 2014 Apr; 59(4):1543-1554. Saberi B, Ybanez MD, Johnson HS, Gaarde WA, Han D, Kaplowitz N. PMID: 23873604; PMCID: PMC3997165.
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    71. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 2014 Jan 09; 5:e989. Win S, Than TA, Fernandez-Checa JC, Kaplowitz N. PMID: 24407242; PMCID: PMC4040675.
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    72. Role of Mitochondria in Alcoholic Liver Disease. Curr Pathobiol Rep. 2013 Sep 01; 1(3):159-168. García-Ruiz C, Kaplowitz N, Fernandez-Checa JC. PMID: 25343061; PMCID: PMC4204424.
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    73. Mechanisms of drug-induced liver injury. Clin Liver Dis. 2013 Nov; 17(4):507-18, vii. Yuan L, Kaplowitz N. PMID: 24099014; PMCID: PMC3793205.
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    74. Avoiding idiosyncratic DILI: two is better than one. Hepatology. 2013 Jul; 58(1):15-7. Kaplowitz N. PMID: 23390057.
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    75. ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol. 2013 Oct; 59(4):805-13. Fernandez A, Matias N, Fucho R, Ribas V, Von Montfort C, Nuño N, Baulies A, Martinez L, Tarrats N, Mari M, Colell A, Morales A, Dubuquoy L, Mathurin P, Bataller R, Caballeria J, Elena M, Balsinde J, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. PMID: 23707365; PMCID: PMC3779525.
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    76. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. PMID: 23453390; PMCID: PMC3622802.
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    77. Current challenges and controversies in drug-induced liver injury. Drug Saf. 2012 Dec 01; 35(12):1099-117. Corsini A, Ganey P, Ju C, Kaplowitz N, Pessayre D, Roth R, Watkins PB, Albassam M, Liu B, Stancic S, Suter L, Bortolini M. PMID: 23137150.
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    78. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; 1830(5):3317-28. Marí M, Morales A, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. PMID: 23123815; PMCID: PMC3578987.
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    79. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 07; 287(50):42165-79. Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. PMID: 23086958; PMCID: PMC3516762.
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    80. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9. von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. PMID: 22687340; PMCID: PMC3445734.
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    81. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul; 56(1):130-9. Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. PMID: 22307928; PMCID: PMC3350836.
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    82. Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling. J Chromatogr A. 2012 Oct 12; 1259:128-37. Gika HG, Ji C, Theodoridis GA, Michopoulos F, Kaplowitz N, Wilson ID. PMID: 22446076; PMCID: PMC3387526.
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    83. Dealing with stress. Hepatology. 2012 Jan; 55(1):3-13. Kaplowitz N. PMID: 22135222.
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    84. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 07; 286(40):35071-8. Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. PMID: 21844199; PMCID: PMC3186406.
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    85. Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. Pharmacogenet Genomics. 2011 Jul; 21(7):365-74. Lee JS, Wang J, Martin M, Germer S, Kenwright A, Benayed R, Spleiss O, Platt A, Pilson R, Hemmings A, Weinblatt ME, Kaplowitz N, Krasnow J. PMID: 21412181.
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    86. Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology. 2011 Jul; 54(1):229-39. Ji C, Kaplowitz N, Lau MY, Kao E, Petrovic LM, Lee AS. PMID: 21503947; PMCID: PMC3125405.
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    87. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011 Jun; 89(6):806-15. Aithal GP, Watkins PB, Andrade RJ, Larrey D, Molokhia M, Takikawa H, Hunt CM, Wilke RA, Avigan M, Kaplowitz N, Bjornsson E, Daly AK. PMID: 21544079.
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    88. Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. Than TA, Lou H, Ji C, Win S, Kaplowitz N. PMID: 21536665; PMCID: PMC3121349.
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    89. The contribution of endoplasmic reticulum stress to liver diseases. Hepatology. 2011 May; 53(5):1752-63. Dara L, Ji C, Kaplowitz N. PMID: 21384408; PMCID: PMC3082587.
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    90. Differential effect of gender on hepatic fat. Pediatr Radiol. 2011 Sep; 41(9):1146-53. Gilsanz V, Chung SA, Kaplowitz N. PMID: 21404026.
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    91. Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis. J Hepatol. 2011 Oct; 55(4):820-7. Lucena MI, Kaplowitz N, Hallal H, Castiella A, García-Bengoechea M, Otazua P, Berenguer M, Fernandez MC, Planas R, Andrade RJ. PMID: 21338638.
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    92. Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. J Proteome Res. 2011 Feb 04; 10(2):705-13. Loftus N, Barnes A, Ashton S, Michopoulos F, Theodoridis G, Wilson I, Ji C, Kaplowitz N. PMID: 21028815; PMCID: PMC3033970.
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    93. Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem. 2010 Dec 17; 285(51):39646-54. Garcia J, Han D, Sancheti H, Yap LP, Kaplowitz N, Cadenas E. PMID: 20937819; PMCID: PMC3000945.
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    94. Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv. 2010 Apr; 10(2):98-111. Jones DP, Lemasters JJ, Han D, Boelsterli UA, Kaplowitz N. PMID: 20368370; PMCID: PMC2895369.
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    95. Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology. 2010 Mar; 51(3):796-805. Shinohara M, Ji C, Kaplowitz N. PMID: 20069651; PMCID: PMC2840074.
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    96. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N. PMID: 20061376; PMCID: PMC2832976.
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    97. Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol. 2010; (196):267-310. Han D, Shinohara M, Ybanez MD, Saberi B, Kaplowitz N. PMID: 20020266.
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    98. Diagnosis, management and prevention of drug-induced liver injury. Gut. 2009 Nov; 58(11):1555-64. Verma S, Kaplowitz N. PMID: 19834119.
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    99. Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal. 2009 Sep; 11(9):2245-63. Han D, Ybanez MD, Ahmadi S, Yeh K, Kaplowitz N. PMID: 19361274; PMCID: PMC2819802.
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    100. Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology. 2009 Jun; 49(6):2001-9. Lucena MI, Andrade RJ, Kaplowitz N, García-Cortes M, Fernández MC, Romero-Gomez M, Bruguera M, Hallal H, Robles-Diaz M, Rodriguez-González JF, Navarro JM, Salmeron J, Martinez-Odriozola P, Pérez-Alvarez R, Borraz Y, Hidalgo R, Spanish Group for the Study of Drug-Induced Liver Disease. PMID: 19475693.
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    101. Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease. Am J Respir Crit Care Med. 2009 May 01; 179(9):835-42. Roberts KE, Fallon MB, Krowka MJ, Brown RS, Trotter JF, Peter I, Tighiouart H, Knowles JA, Rabinowitz D, Benza RL, Badesch DB, Taichman DB, Horn EM, Zacks S, Kaplowitz N, Kawut SM, Pulmonary Vascular Complications of Liver Disease Study Group. PMID: 19218192; PMCID: PMC2675568.
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    102. How to protect against acetaminophen: don't ask for JUNK. Gastroenterology. 2008 Oct; 135(4):1047-51. Kaplowitz N, Shinohara M, Liu ZX, Han D. PMID: 18782575.
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    103. Glutathione in liver diseases and hepatotoxicity. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):29-41. Yuan L, Kaplowitz N. PMID: 18786561.
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    104. Clinical risk factors for portopulmonary hypertension. Hepatology. 2008 Jul; 48(1):196-203. Kawut SM, Krowka MJ, Trotter JF, Roberts KE, Benza RL, Badesch DB, Taichman DB, Horn EM, Zacks S, Kaplowitz N, Brown RS, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group. PMID: 18537192; PMCID: PMC2824885.
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    105. Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology. 2008 Oct; 135(4):1168-75. Fallon MB, Krowka MJ, Brown RS, Trotter JF, Zacks S, Roberts KE, Shah VH, Kaplowitz N, Forman L, Wille K, Kawut SM, Pulmonary Vascular Complications of Liver Disease Study Group. PMID: 18644373; PMCID: PMC2824882.
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    106. Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. Ji C, Shinohara M, Vance D, Than TA, Ookhtens M, Chan C, Kaplowitz N. PMID: 18498552; PMCID: PMC2596885.
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    107. Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C50-63. Saberi B, Shinohara M, Ybanez MD, Hanawa N, Gaarde WA, Kaplowitz N, Han D. PMID: 18463227; PMCID: PMC2493548.
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    108. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem. 2008 May 16; 283(20):13565-77. Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N. PMID: 18337250; PMCID: PMC2376214.
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    109. Endoplasmic reticulum stress and liver injury. Semin Liver Dis. 2007 Nov; 27(4):367-77. Kaplowitz N, Than TA, Shinohara M, Ji C. PMID: 17979073.
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    110. Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology. 2007 Nov; 46(5):1586-96. Ji C, Shinohara M, Kuhlenkamp J, Chan C, Kaplowitz N. PMID: 17705221; PMCID: PMC2642650.
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    111. Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem. 2007 Oct 05; 282(40):29470-81. Lou H, Kaplowitz N. PMID: 17690092.
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    112. Mechanisms of drug-induced liver disease. Clin Liver Dis. 2007 Aug; 11(3):459-75, v. Gunawan BK, Kaplowitz N. PMID: 17723915.
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    113. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr. 2007 Jul; 86(1):14-24. Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, Kharbanda KK, Liu QY, Lu SC, McClain CJ, Swanson C, Zakhari S. PMID: 17616758.
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    114. Drug-induced liver injury. Drug Saf. 2007; 30(4):277-94. Abboud G, Kaplowitz N. PMID: 17408305.
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    115. Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology. 2006 Dec; 44(6):1581-8. Andrade RJ, Lucena MI, Kaplowitz N, García-Munoz B, Borraz Y, Pachkoria K, García-Cortés M, Fernández MC, Pelaez G, Rodrigo L, Durán JA, Costa J, Planas R, Barriocanal A, Guarner C, Romero-Gomez M, Munoz-Yagüe T, Salmerón J, Hidalgo R. PMID: 17133470.
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    116. Current concepts and controversies in the treatment of alcoholic hepatitis. World J Gastroenterol. 2006 Nov 21; 12(43):6909-21. Rongey C, Kaplowitz N. PMID: 17109510; PMCID: PMC4087332.
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    117. Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S7-9. Kaplowitz N, Ji C. PMID: 16958678.
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    118. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. Liu ZX, Kaplowitz N. PMID: 16859400.
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    119. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA. 2006 Jul 05; 296(1):87-93. Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC. PMID: 16820551.
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    120. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006 Jul; 131(1):165-78. Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. PMID: 16831600.
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    121. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol. 2006 Nov; 45(5):717-24. Ji C, Chan C, Kaplowitz N. PMID: 16879892.
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    122. ER stress: can the liver cope? J Hepatol. 2006 Aug; 45(2):321-33. Ji C, Kaplowitz N. PMID: 16797772.
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    123. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology. 2006 Jun; 43(6):1220-30. Liu ZX, Han D, Gunawan B, Kaplowitz N. PMID: 16729305.
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    124. Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med. 2006 Aug 15; 41(4):627-39. Han D, Hanawa N, Saberi B, Kaplowitz N. PMID: 16863996.
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    125. Drug hepatotoxicity. Clin Liver Dis. 2006 May; 10(2):207-17, vii. Nathwani RA, Kaplowitz N. PMID: 16971258.
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    126. Rules and laws of drug hepatotoxicity. Pharmacoepidemiol Drug Saf. 2006 Apr; 15(4):231-3. Kaplowitz N. PMID: 16552791.
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    127. Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G1-7. Han D, Hanawa N, Saberi B, Kaplowitz N. PMID: 16500922.
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    128. Liver biology and pathobiology. Hepatology. 2006 Feb; 43(2 Suppl 1):S235-8. Kaplowitz N. PMID: 16447293.
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    129. Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res. 2005 Aug; 29(8):1496-503. Ji C, Mehrian-Shai R, Chan C, Hsu YH, Kaplowitz N. PMID: 16131858; PMCID: PMC1432051.
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    130. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov. 2005 Jun; 4(6):489-99. Kaplowitz N. PMID: 15931258.
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    131. Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol. 2005 May 01; 204(3):263-73. Fernandez-Checa JC, Kaplowitz N. PMID: 15845418.
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    132. Serum alanine aminotransferase in skeletal muscle diseases. Hepatology. 2005 Feb; 41(2):380-2. Nathwani RA, Pais S, Reynolds TB, Kaplowitz N. PMID: 15660433.
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    133. Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. Am J Gastroenterol. 2005 Feb; 100(2):295-8. Nathwani RA, Kumar SR, Reynolds TB, Kaplowitz N. PMID: 15667485.
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    134. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004 Dec; 127(6):1760-74. Liu ZX, Govindarajan S, Kaplowitz N. PMID: 15578514.
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    135. Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol. 2004 Dec; 41(6):1062-4. Neff GW, Reddy KR, Durazo FA, Meyer D, Marrero R, Kaplowitz N. PMID: 15582145.
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    136. Statin-induced hepatotoxicity. Gastroenterology. 2004 Oct; 127(4):1278; author reply 1278-9. Kaplowitz N. PMID: 15481021.
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    137. Liver injury associated with the beta-interferons for MS. Neurology. 2004 Sep 28; 63(6):1142-3; author reply 1142-3. Francis GS, Kaplowitz N, Alteri E. PMID: 15457586.
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    138. Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology. 2004 Aug; 40(2):442-51. Ji C, Deng Q, Kaplowitz N. PMID: 15368449.
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    139. Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology. 2004 Jul; 40(1):23-6. Kaplowitz N. PMID: 15239082.
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    140. Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J Gastroenterol. 2004 Jun 15; 10(12):1699-708. Ji C, Kaplowitz N. PMID: 15188490; PMCID: PMC4572253.
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    141. Clinical perspectives on xenobiotic-induced hepatotoxicity. Drug Metab Rev. 2004 May; 36(2):301-12. Gunawan B, Kaplowitz N. PMID: 15237856.
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    142. Drug-induced liver injury. Clin Infect Dis. 2004 Mar 01; 38 Suppl 2:S44-8. Kaplowitz N. PMID: 14986274.
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    143. Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochem Pharmacol. 2004 Feb 01; 67(3):439-51. Han D, Matsumaru K, Rettori D, Kaplowitz N. PMID: 15037196.
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    144. Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria. Mol Pharmacol. 2003 Nov; 64(5):1136-44. Han D, Canali R, Rettori D, Kaplowitz N. PMID: 14573763.
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    145. Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology. 2003 Sep; 38(3):692-702. Coll O, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. PMID: 12939596.
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    146. Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. Lou H, Ookhtens M, Stolz A, Kaplowitz N. PMID: 12893631.
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    147. Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology. 2003 Jun; 37(6):1425-34. Matsumaru K, Ji C, Kaplowitz N. PMID: 12774022.
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    148. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May; 124(5):1488-99. Ji C, Kaplowitz N. PMID: 12730887.
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    149. Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology. 2003 Mar; 124(3):708-24. Lluis JM, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. PMID: 12612910.
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    150. Did this drug cause my patient's hepatitis? Ann Intern Med. 2003 Jan 21; 138(2):159-60; author reply 159-60. Kaplowitz N, Lewis JH, Watkins PB. PMID: 12529106.
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    151. Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance. Drug Saf. 2003; 26(11):815-27. Francis GS, Grumser Y, Alteri E, Micaleff A, O'Brien F, Alsop J, Stam Moraga M, Kaplowitz N. PMID: 12908850.
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    152. Immune-mediated drug-induced liver disease. Clin Liver Dis. 2002 Aug; 6(3):755-74. Liu ZX, Kaplowitz N. PMID: 12362579.
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    153. Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology. 2002 Jul; 36(1):55-64. Nagai H, Matsumaru K, Feng G, Kaplowitz N. PMID: 12085349.
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    154. Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G825-34. Feng G, Kaplowitz N. PMID: 11960779.
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    155. The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol. 2002 Feb; 61(2):425-35. Mittur A, Wolkoff AW, Kaplowitz N. PMID: 11809868.
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    156. Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis. 2002; 22(2):137-44. Kaplowitz N. PMID: 12016545.
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    157. Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. Hepatology. 2001 Nov; 34(5):964-71. Colell A, Coll O, García-Ruiz C, París R, Tiribelli C, Kaplowitz N, Fernández-Checa JC. PMID: 11679967.
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    158. How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):171S-181S. Tsukamoto H, Takei Y, McClain CJ, Joshi-Barve S, Hill D, Schmidt J, Deaciuc I, Barve S, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC, Yokoyama H, Okamura Y, Nakamura Y, Ishii H, Chawla RK, Barve S, Joshi-Barve S, Watson W, Nelson W, Lin M, Ohata M, Motomura K, Enomoto N, Ikejima K, Kitamura T, Oide H, Hirose M, Bradford BU, Rivera CA, Kono H, Peter S, Yamashina S, Konno A, Ishikawa M, Shimizu H, Sato N, Thurman R. PMID: 11391068.
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    159. Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses. Invest Ophthalmol Vis Sci. 2001 Feb; 42(2):409-16. Kannan R, Ouyang B, Wawrousek E, Kaplowitz N, Andley UP. PMID: 11157875.
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    160. Causality assessment versus guilt-by-association in drug hepatotoxicity. Hepatology. 2001 Jan; 33(1):308-10. Kaplowitz N. PMID: 11124850.
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    161. Drug-induced liver disorders: implications for drug development and regulation. Drug Saf. 2001; 24(7):483-90. Kaplowitz N. PMID: 11444721.
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    162. Radiation inactivation studies of hepatic sinusoidal reduced glutathione transport system. Biochim Biophys Acta. 2000 Apr 05; 1464(2):207-18. Mittur AV, Kaplowitz N, Kempner ES, Ookhtens M. PMID: 10727608.
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    163. Cell death at the millennium. Implications for liver diseases. Clin Liver Dis. 2000 Feb; 4(1):1-23, v. Kaplowitz N. PMID: 11232179.
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    164. Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody. J Clin Invest. 2000 Feb; 105(3):329-39. Feng G, Kaplowitz N. PMID: 10675359; PMCID: PMC377439.
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    165. GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC. Brain Res. 2000 Jan 10; 852(2):374-82. Kannan R, Chakrabarti R, Tang D, Kim KJ, Kaplowitz N. PMID: 10678765.
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    166. Mechanisms of liver cell injury. J Hepatol. 2000; 32(1 Suppl):39-47. Kaplowitz N. PMID: 10728793.
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    167. Avoiding hepatic injury from drugs. Gastroenterology. 1999 Oct; 117(4):759. Kaplowitz N. PMID: 10500055.
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    168. GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter. J Neurochem. 1999 Jul; 73(1):390-9. Kannan R, Mittur A, Bao Y, Tsuruo T, Kaplowitz N. PMID: 10386992.
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    169. Hepatotoxicity of psychotropic drugs. Hepatology. 1999 May; 29(5):1347-51. Selim K, Kaplowitz N. PMID: 10216114.
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    170. Protection from oxidant injury by sodium-dependent GSH uptake in retinal Müller cells. Exp Eye Res. 1999 May; 68(5):609-16. Kannan R, Bao Y, Wang Y, Sarthy VP, Kaplowitz N. PMID: 10328975.
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    171. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 1998 Dec; 115(6):1541-51. Colell A, García-Ruiz C, Miranda M, Ardite E, Marí M, Morales A, Corrales F, Kaplowitz N, Fernández-Checa JC. PMID: 9834283.
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    172. Glutathione transport in immortalized HLE cells and expression of transport in HLE cell poly(A)+ RNA-injected Xenopus laevis oocytes. Invest Ophthalmol Vis Sci. 1998 Jul; 39(8):1379-86. Kannan R, Bao Y, Mittur A, Andley UP, Kaplowitz N. PMID: 9660486.
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    173. Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation. Am J Physiol. 1998 05; 274(5):G923-30. Mittur AV, Kaplowitz N, Kempner ES, Ookhtens M. PMID: 9612274.
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    174. Changes in glutathione homeostasis during liver regeneration in the rat. Hepatology. 1998 Jan; 27(1):147-53. Huang ZZ, Li H, Cai J, Kuhlenkamp J, Kaplowitz N, Lu SC. PMID: 9425930.
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    175. Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine. Semin Liver Dis. 1998; 18(4):313-29. Ookhtens M, Kaplowitz N. PMID: 9875551.
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    176. Mitochondrial glutathione: importance and transport. Semin Liver Dis. 1998; 18(4):389-401. Fernández-Checa JC, Kaplowitz N, García-Ruiz C, Colell A. PMID: 9875556.
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    177. Hepatotoxicity of herbal remedies: insights into the intricacies of plant-animal warfare and cell death. Gastroenterology. 1997 Oct; 113(4):1408-12. Kaplowitz N. PMID: 9322538.
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    178. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology. 1997 Sep; 26(3):699-708. Colell A, García-Ruiz C, Morales A, Ballesta A, Ookhtens M, Rodés J, Kaplowitz N, Fernández-Checa JC. PMID: 9303501.
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    179. GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol. 1997 Jul; 273(1 Pt 1):G7-17. Fernández-Checa JC, Kaplowitz N, García-Ruiz C, Colell A, Miranda M, Marí M, Ardite E, Morales A. PMID: 9252504.
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    180. Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 09; 53(9):1339-45. DeLeve LD, Wang X, Kaplowitz N, Shulman HM, Bart JA, van der Hoek A. PMID: 9214695.
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    181. Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium. Exp Eye Res. 1997 Apr; 64(4):615-26. Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. PMID: 9227280.
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    182. Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am J Physiol. 1997 Feb; 272(2 Pt 1):G374-82. Lu SC, Kuhlenkamp J, Wu H, Sun WM, Stone L, Kaplowitz N. PMID: 9124363.
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    183. Oxidative stress and alcoholic liver disease. Alcohol Health Res World. 1997; 21(4):321-4. Fernández-Checa JC, Kaplowitz N, Colell A, García-Ruiz C. PMID: 15706743; PMCID: PMC6827680.
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    184. Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. PMID: 8843923.
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    185. Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats. Hepatology. 1996 Jul; 24(1):253-8. Lu SC, Cai J, Kuhlenkamp J, Sun WM, Takikawa H, Takenaka O, Horie T, Yi J, Kaplowitz N. PMID: 8707271.
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    186. Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics. Am J Physiol. 1996 Jun; 270(6 Pt 1):G969-75. Fernández-Checa JC, García-Ruiz C, Colell A, Yi JR, Kaplowitz N. PMID: 8764204.
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    187. Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats. Hepatology. 1996 Jun; 23(6):1642-9. Takikawa H, Sugiyama Y, Fernandez-Checa JC, Kuhlenkamp J, Ookhtens M, Kaplowitz N. PMID: 8675188.
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    188. GSH transporters: molecular characterization and role in GSH homeostasis. Biol Chem Hoppe Seyler. 1996 May; 377(5):267-73. Kaplowitz N, Fernández-Checa JC, Kannan R, Garcia-Ruiz C, Ookhtens M, Yi JR. PMID: 8828817.
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    189. Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis. 1996 May; 16(2):147-58. Fernández-Checa JC, Yi JR, García Ruiz C, Ookhtens M, Kaplowitz N. PMID: 8781020.
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    190. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. PMID: 8621654.
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    191. Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells. J Clin Invest. 1996 Mar 15; 97(6):1488-96. Lu SC, Sun WM, Yi J, Ookhtens M, Sze G, Kaplowitz N. PMID: 8617882; PMCID: PMC507209.
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    192. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology. 1996 Mar; 23(3):589-99. DeLeve LD, Wang X, Kuhlenkamp JF, Kaplowitz N. PMID: 8617441.
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    193. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp Eye Res. 1996 Jan; 62(1):29-37. Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. PMID: 8674510.
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    194. Oxidative stress and liver disease. Prog Liver Dis. 1996; 14:131-59. Kaplowitz N, Tsukamoto H. PMID: 9055577.
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    195. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. DeLeve LD, Kaplowitz N. PMID: 8749899.
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    196. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol. 1995 Nov; 48(5):825-34. García-Ruiz C, Colell A, Morales A, Kaplowitz N, Fernández-Checa JC. PMID: 7476912.
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    197. Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol Appl Pharmacol. 1995 Oct; 134(2):264-72. Runnegar M, Berndt N, Kaplowitz N. PMID: 7570603.
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    198. Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. PMID: 7635653.
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    199. Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes. J Biol Chem. 1995 Jul 07; 270(27):15946-9. García-Ruiz C, Morales A, Colell A, Rodés J, Yi JR, Kaplowitz N, Fernández-Checa JC. PMID: 7608148.
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    200. Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1495-9. Yi JR, Lu S, Fernández-Checa J, Kaplowitz N. PMID: 7878007; PMCID: PMC42546.
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    201. Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology. 1995 Jan; 21(1):207-14. García-Ruiz C, Morales A, Colell A, Ballesta A, Rodés J, Kaplowitz N, Fernández-Checa JC. PMID: 7806156.
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    202. Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp Eye Res. 1994 Oct; 59(4):487-96. Zlokovic BV, Mackic JB, McComb JG, Kaplowitz N, Weiss MH, Kannan R. PMID: 7859824.
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    203. Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver. Mol Pharmacol. 1994 Sep; 46(3):578-85. Lu SC, Kuhlenkamp J, Ge JL, Sun WM, Kaplowitz N. PMID: 7935341.
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    204. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest. 1994 Jul; 94(1):193-201. García-Ruiz C, Morales A, Ballesta A, Rodés J, Kaplowitz N, Fernández-Checa JC. PMID: 8040260; PMCID: PMC296297.
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    205. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. PMID: 8198602.
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    206. Role of BSP/bilirubin binding protein and bilitranslocase in glutathione uptake in rat basolateral liver plasma membrane vesicles. Biochem Biophys Res Commun. 1994 Apr 29; 200(2):1079-85. Torres AM, Kaplowitz N, Tiribelli C. PMID: 8179585.
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    207. Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics. J Clin Invest. 1994 Apr; 93(4):1841-5. Yi JR, Lu S, Fernandez-Checa J, Kaplowitz N. PMID: 8163683; PMCID: PMC294260.
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    208. Distribution of 3 alpha-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: comparison with glutathione S-transferase subunits. J Gastroenterol. 1994 Apr; 29(2):115-9. Yamamuro W, Stolz A, Takikawa H, Sugimoto M, Kaplowitz N. PMID: 8012502.
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    209. Bidirectional membrane transport of intact glutathione in Hep G2 cells. Am J Physiol. 1993 Dec; 265(6 Pt 1):G1128-34. Sze G, Kaplowitz N, Ookhtens M, Lu SC. PMID: 7904127.
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    210. Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol. 1993 Nov-Dec; 10(6):469-75. Fernández-Checa JC, Hirano T, Tsukamoto H, Kaplowitz N. PMID: 8123202.
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    211. Identification and purification of a human liver cytosolic tocopherol binding protein. Protein Expr Purif. 1993 Oct; 4(5):382-9. Kuhlenkamp J, Ronk M, Yusin M, Stolz A, Kaplowitz N. PMID: 8251749.
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    212. Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused livers. J Clin Invest. 1993 Sep; 92(3):1188-97. Lu SC, Ge JL, Huang HY, Kuhlenkamp J, Kaplowitz N. PMID: 8376579; PMCID: PMC288257.
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    213. Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles. J Biol Chem. 1993 May 25; 268(15):10836-41. Fernández-Checa JC, Ookhtens M, Kaplowitz N. PMID: 8496149.
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    214. Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes. J Biol Chem. 1993 Feb 05; 268(4):2324-8. Fernández-Checa JC, Yi JR, Garcia-Ruiz C, Knezic Z, Tahara SM, Kaplowitz N. PMID: 8428906.
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    215. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology. 1992 Dec; 16(6):1423-7. Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. PMID: 1446896.
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    216. Transport of glutathione at blood-brain barrier of the rat: inhibition by glutathione analogs and age-dependence. J Pharmacol Exp Ther. 1992 Dec; 263(3):964-70. Kannan R, Kuhlenkamp JF, Ookhtens M, Kaplowitz N. PMID: 1469653.
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    217. Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles. J Biol Chem. 1992 Nov 05; 267(31):22256-64. García-Ruiz C, Fernández-Checa JC, Kaplowitz N. PMID: 1429578.
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    218. Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo. J Clin Invest. 1992 Aug; 90(2):524-32. Lu SC, Ge JL, Kuhlenkamp J, Kaplowitz N. PMID: 1353765; PMCID: PMC443130.
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    219. The relationship between biliary secretion of bilirubin and glutathione in the rat. Gastroenterol Jpn. 1992 Jun; 27(3):369-73. Yoshida H, Kuronuma Y, Iijima M, Harada T, Kuhlenkamp J, Kaplowitz N. PMID: 1624080.
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    220. Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals. Am J Physiol. 1992 Apr; 262(4 Pt 1):G669-76. Komatsu H, Koo A, Ghadishah E, Zeng H, Kuhlenkamp JF, Inoue M, Guth PH, Kaplowitz N. PMID: 1373565.
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    221. Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion. Hepatology. 1992 Mar; 15(3):507-14. Koo A, Komatsu H, Tao G, Inoue M, Guth PH, Kaplowitz N. PMID: 1312056.
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    222. Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol. J Lipid Res. 1992 Mar; 33(3):343-50. Yoshida H, Yusin M, Ren I, Kuhlenkamp J, Hirano T, Stolz A, Kaplowitz N. PMID: 1569384.
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    223. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J Biol Chem. 1992 Jan 25; 267(3):1667-73. Fernández-Checa JC, Takikawa H, Horie T, Ookhtens M, Kaplowitz N. PMID: 1730711.
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    224. Zonal distribution of cysteine uptake in the perfused rat liver. J Biol Chem. 1992 Jan 05; 267(1):192-6. Saiki H, Chan ET, Wong E, Yamamuro W, Ookhtens M, Kaplowitz N. PMID: 1730587.
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    225. Effect of phorone and allopurinol on ischemia-reperfusion injury in gastrointestinal mucosa of the rat. Pharmacology. 1992; 44(6):334-43. Yasue N, Chan ET, Kaplowitz N, Guth PH. PMID: 1508963.
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    226. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther. 1991 Dec; 52(3):287-305. DeLeve LD, Kaplowitz N. PMID: 1820580.
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    227. Effect of indomethacin on the uptake, metabolism and excretion of 3-oxocholic acid: studies in isolated hepatocytes and perfused rat liver. Biochim Biophys Acta. 1991 Jul 30; 1084(3):247-50. Takikawa H, Fernandez-Checa JC, Kuhlenkamp J, Stolz A, Ookhtens M, Kaplowitz N. PMID: 1888771.
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    228. Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat. J Clin Invest. 1991 Jul; 88(1):260-9. Lu SC, Kuhlenkamp J, Garcia-Ruiz C, Kaplowitz N. PMID: 1647417; PMCID: PMC296028.
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    229. Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest. 1991 Feb; 87(2):397-405. Fernández-Checa JC, García-Ruiz C, Ookhtens M, Kaplowitz N. PMID: 1991826; PMCID: PMC295090.
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    230. Importance and regulation of hepatic glutathione. Semin Liver Dis. 1990 Nov; 10(4):251-66. DeLeve LD, Kaplowitz N. PMID: 2281333.
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    231. The use of monochlorobimane to determine hepatic GSH levels and synthesis. Anal Biochem. 1990 Nov 01; 190(2):212-9. Fernández-Checa JC, Kaplowitz N. PMID: 2291468.
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    232. Hormonal regulation of glutathione efflux. J Biol Chem. 1990 Sep 25; 265(27):16088-95. Lu SC, Garcia-Ruiz C, Kuhlenkamp J, Ookhtens M, Salas-Prato M, Kaplowitz N. PMID: 2168879.
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    233. Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. J Clin Invest. 1990 Jun; 85(6):2009-13. Kannan R, Kuhlenkamp JF, Jeandidier E, Trinh H, Ookhtens M, Kaplowitz N. PMID: 1971830; PMCID: PMC296671.
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    234. Inhibition of GSH efflux from rat liver by methionine: effects of GSH synthesis in cells and perfused organ. Am J Physiol. 1990 Jun; 258(6 Pt 1):G967-73. Fernandez-Checa JC, Maddatu T, Ookhtens M, Kaplowitz N. PMID: 2113771.
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    235. Calcium compartmentation and exchange rates in primary hepatocyte culture. Anal Biochem. 1990 May 15; 187(1):187-96. Gish RG, Garcia C, Reedy T, Kaplowitz N, Langer GA. PMID: 2372115.
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    236. Oxidation and reduction of bile acid precursors by rat hepatic 3 alpha-hydroxysteroid dehydrogenase and inhibition by bile acids and indomethacin. Biochim Biophys Acta. 1990 Apr 02; 1043(2):153-6. Takikawa H, Stolz A, Kuroki S, Kaplowitz N. PMID: 2317526.
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    237. Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver. J Biol Chem. 1990 Feb 05; 265(4):2132-6. Takikawa H, Stolz A, Sugiyama Y, Yoshida H, Yamanaka M, Kaplowitz N. PMID: 2153675.
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    238. The use of isolated perfused liver in studies of biological transport processes. Methods Enzymol. 1990; 192:485-95. Ookhtens M, Kaplowitz N. PMID: 2074805.
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    239. Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest. 1989 Apr; 83(4):1247-52. Fernandez-Checa JC, Ookhtens M, Kaplowitz N. PMID: 2703532; PMCID: PMC303814.
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    240. The role of cytoplasmic proteins in hepatic bile acid transport. Annu Rev Physiol. 1989; 51:161-76. Stolz A, Takikawa H, Ookhtens M, Kaplowitz N. PMID: 2653179.
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    241. Tocopherol-binding proteins of hepatic cytosol. Ann N Y Acad Sci. 1989; 570:85-94. Kaplowitz N, Yoshida H, Kuhlenkamp J, Slitsky B, Ren I, Stolz A. PMID: 2698112.
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    242. Role of glutathione status in protection against ethanol-induced gastric lesions. Pharmacology. 1989; 38(1):57-60. Lu SC, Kuhlenkamp J, Robert A, Kaplowitz N. PMID: 2727045.
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    243. Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1988 Oct; 255(4 Pt 1):G403-8. Fernandez-Checa JC, Ren C, Aw TY, Ookhtens M, Kaplowitz N. PMID: 3177640.
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    244. Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms. J Clin Invest. 1988 Aug; 82(2):608-16. Ookhtens M, Lyon I, Fernandez-Checa J, Kaplowitz N. PMID: 3403719; PMCID: PMC303555.
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    245. Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human hepatic GSH S-transferases. Biochim Biophys Acta. 1988 Apr 28; 954(1):37-43. Takikawa H, Sugiyama Y, Kaplowitz N. PMID: 3358937.
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    246. Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids. J Lipid Res. 1988 Mar; 29(3):279-86. Takikawa H, Kaplowitz N. PMID: 3379340.
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    247. Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver. Biochem Pharmacol. 1987 Nov 15; 36(22):4015-7. Ookhtens M, Lyon I, Kaplowitz N. PMID: 3689434.
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    248. Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3 alpha-hydroxysteroid dehydrogenase. I. Studies with the purified enzyme, isolated rat hepatocytes, and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):852-60. Takikawa H, Stolz A, Kaplowitz N. PMID: 3476498; PMCID: PMC442312.
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    249. Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3 alpha-hydroxysteroid dehydrogenase. II. Studies in the prograde and retrograde single-pass, perfused rat liver and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):861-6. Takikawa H, Ookhtens M, Stolz A, Kaplowitz N. PMID: 3476499; PMCID: PMC442313.
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    250. Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol. J Clin Invest. 1987 Jul; 80(1):57-62. Fernandez-Checa JC, Ookhtens M, Kaplowitz N. PMID: 2885343; PMCID: PMC442201.
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    251. A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army. N Engl J Med. 1987 Apr 16; 316(16):965-70. Seeff LB, Beebe GW, Hoofnagle JH, Norman JE, Buskell-Bales Z, Waggoner JG, Kaplowitz N, Koff RS, Petrini JL, Schiff ER, et al. PMID: 2436048.
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    252. Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver. Biochem Biophys Res Commun. 1987 Feb 27; 143(1):377-82. Aw TY, Ookhtens M, Kuhlenkamp JF, Kaplowitz N. PMID: 3827928.
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    253. 3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance. J Clin Invest. 1987 Feb; 79(2):427-34. Stolz A, Takikawa H, Sugiyama Y, Kuhlenkamp J, Kaplowitz N. PMID: 3468121; PMCID: PMC424091.
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    254. Subunit heterogeneity of cationic human hepatic glutathione S-transferases. Pharmacology. 1987; 35(2):65-78. Sugimoto M, Takikawa H, Stolz A, Kaplowitz N. PMID: 3628463.
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    255. Binding of bile acids, oleic acid, and organic anions by rat and human hepatic Z protein. Arch Biochem Biophys. 1986 Nov 15; 251(1):385-92. Takikawa H, Kaplowitz N. PMID: 3789743.
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    256. Purification of a 32.5 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroids. FEBS Lett. 1986 Oct 27; 207(2):193-7. Takikawa H, Stolz A, Kaplowitz N. PMID: 3464463.
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    257. Binding of bile acids by glutathione S-transferases from rat liver. J Lipid Res. 1986 Sep; 27(9):955-66. Takikawa H, Sugiyama Y, Kaplowitz N. PMID: 3783048.
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    258. Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes. Am J Physiol. 1986 Sep; 251(3 Pt 1):G354-61. Aw TY, Ookhtens M, Kaplowitz N. PMID: 3752249.
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    259. Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids. J Lipid Res. 1986 Jun; 27(6):652-7. Takikawa H, Stolz A, Sugimoto M, Sugiyama Y, Kaplowitz N. PMID: 3746134.
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    260. Drug-induced hepatotoxicity. Ann Intern Med. 1986 Jun; 104(6):826-39. Kaplowitz N, Aw TY, Simon FR, Stolz A. PMID: 3518564.
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    261. Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution. Hepatology. 1986 May-Jun; 6(3):433-9. Stolz A, Sugiyama Y, Kuhlenkamp J, Osadchey B, Yamada T, Belknap W, Balistreri W, Kaplowitz N. PMID: 3710432.
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    262. Kinetics of glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1986 Feb; 250(2 Pt 1):G236-43. Aw TY, Ookhtens M, Ren C, Kaplowitz N. PMID: 3953803.
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    263. Organic anion-binding by human hepatic GSH S-transferases. Biochem Pharmacol. 1986 Jan 15; 35(2):354-6. Takikawa H, Sugiyama Y, Stolz A, Sugimoto M, Kaplowitz N. PMID: 3942604.
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    264. Gamma-glutamylcysteine: a substrate for glutathione S-transferases. Biochem Pharmacol. 1985 Oct 15; 34(20):3643-7. Sugimoto M, Kuhlenkamp J, Ookhtens M, Aw TY, Reeve J, Kaplowitz N. PMID: 4052106.
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    265. Modulating effect of thiol-disulfide status on [14C]aminopyrine accumulation in the isolated parietal cell. J Biol Chem. 1985 Jul 05; 260(13):8020-5. Olson CE, Soll AH, Kaplowitz N. PMID: 4008488.
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    266. Acetaldehyde-dependent oxidation of glutathione catalyzed by rat liver cytosol. Biochem Biophys Res Commun. 1985 Jun 28; 129(3):949-57. Lyon I, Kaplowitz N. PMID: 4015660.
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    267. Disease-specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr. 1985 May-Jun; 9(3):288-95. Cerra FB, Cheung NK, Fischer JE, Kaplowitz N, Schiff ER, Dienstag JL, Bower RH, Mabry CD, Leevy CM, Kiernan T. PMID: 3892073.
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    268. Sinusoidal efflux of glutathione in the perfused rat liver. Evidence for a carrier-mediated process. J Clin Invest. 1985 Jan; 75(1):258-65. Ookhtens M, Hobdy K, Corvasce MC, Aw TY, Kaplowitz N. PMID: 3965506; PMCID: PMC423434.
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    269. The regulation of hepatic glutathione. Annu Rev Pharmacol Toxicol. 1985; 25:715-44. Kaplowitz N, Aw TY, Ookhtens M. PMID: 3890714.
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    270. Identification and partial purification of a unique phenolic steroid sulphotransferase in rat liver cytosol. Biochem J. 1984 Dec 15; 224(3):947-53. Sugiyama Y, Stolz A, Sugimoto M, Kuhlenkamp J, Yamada T, Kaplowitz N. PMID: 6596951; PMCID: PMC1144532.
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    271. Identification and purification of a 36 kDa bile acid binder in human hepatic cytosol. FEBS Lett. 1984 Nov 05; 177(1):31-5. Stolz A, Sugiyama Y, Kuhlenkamp J, Kaplowitz N. PMID: 6500050.
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    272. Comparison of the binding affinities of five forms of rat glutathione S-transferases for bilirubin, sulfobromophthalein and hematin. Biochem Pharmacol. 1984 Nov 01; 33(21):3511-3. Sugiyama Y, Sugimoto M, Stolz A, Kaplowitz N. PMID: 6497907.
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    273. Evidence for a common high affinity binding site on glutathione S-transferase B for lithocholic acid and bilirubin. J Lipid Res. 1984 Nov; 25(11):1177-83. Sugiyama Y, Stolz A, Sugimoto M, Kaplowitz N. PMID: 6520541.
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    274. Comparison of binding of thyroid hormone analogues to hepatic organic anion binding proteins. Biochim Biophys Acta. 1984 Sep 28; 801(2):184-8. Sugiyama Y, Stolz A, Hershman JM, Kaplowitz N. PMID: 6477965.
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    275. Role of glutathione in gastric mucosal cytoprotection. Am J Physiol. 1984 Sep; 247(3 Pt 1):G296-304. Robert A, Eberle D, Kaplowitz N. PMID: 6591806.
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    276. Inhibition of glutathione efflux from isolated rat hepatocytes by methionine. J Biol Chem. 1984 Aug 10; 259(15):9355-8. Aw TY, Ookhtens M, Kaplowitz N. PMID: 6746650.
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    277. Quantitation and characterization of a newly described organic anion binder by radioimmunoassay. Biochim Biophys Acta. 1984 Jul 30; 800(2):171-7. Stolz A, Yamada T, Sugiyama Y, Belknap W, Kaplowitz N. PMID: 6743689.
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    278. Binding of glutathione by rat liver cytosol. Pharmacology. 1984; 28(2):61-6. Sugiyama Y, Kaplowitz N. PMID: 6709688.
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    279. Newly identified bile acid binders in rat liver cytosol. Purification and comparison with glutathione S-transferases. J Biol Chem. 1983 Mar 25; 258(6):3602-7. Sugiyama Y, Yamada T, Kaplowitz N. PMID: 6833218.
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    280. Factors influencing the efflux of hepatic glutathione into bile in rats. J Pharmacol Exp Ther. 1983 Jan; 224(1):141-7. Kaplowitz N, Eberle DE, Petrini J, Touloukian J, Corvasce MC, Kuhlenkamp J. PMID: 6848740.
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    281. Newly identified organic anion-binding proteins in rat liver cytosol. Biochim Biophys Acta. 1982 Dec 20; 709(2):342-52. Sugiyama Y, Yamada T, Kaplowitz N. PMID: 6817804.
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    282. Propylthiouracil treatment for alcoholic hepatitis: should it and does it work? Gastroenterology. 1982 Jun; 82(6):1468-71. Kaplowitz N. PMID: 7067965.
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    283. Identification of hepatic Z-protein in a marine elasmobranch, Platyrhinoides triseriata. Biochem J. 1982 May 01; 203(2):377-81. Sugiyama Y, Yamada T, Kaplowitz N. PMID: 7115292; PMCID: PMC1158240.
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    284. Glutathione S-transferases in elasmobranch liver. Molecular heterogeneity, catalytic and binding properties, and purification. Biochem J. 1981 Dec 01; 199(3):749-56. Sugiyama Y, Yamada T, Kaplowitz N. PMID: 7340827; PMCID: PMC1163433.
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    285. The importance and regulation of hepatic glutathione. Yale J Biol Med. 1981 Nov-Dec; 54(6):497-502. Kaplowitz N. PMID: 7342494; PMCID: PMC2596047.
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    286. Inhibition of rat hepatic thyroxine 5'-monodeiodinase by propylthiouracil: relation to site of interaction of thyroxine and glutathione. J Endocrinol Invest. 1981 Oct-Dec; 4(4):379-87. Yamada T, Chopra IJ, Kaplowitz N. PMID: 7334183.
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    287. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981 Sep-Oct; 1(5):431-5. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J. PMID: 7308988.
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    288. The hepatocellular uptake and biliary excretion of endotoxin in the rat. Hepatology. 1981 Sep-Oct; 1(5):401-7. Maitra SK, Rachmilewitz D, Eberle D, Kaplowitz N. PMID: 7030904.
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    289. Halothane-induced hepatic disease. Semin Liver Dis. 1981 May; 1(2):134-42. Touloukian J, Kaplowitz N. PMID: 7347017.
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    290. Rapid oxidation in vitro of endogenous and exogenous glutathione in bile of rats. J Biol Chem. 1981 Mar 10; 256(5):2115-7. Eberle D, Clarke R, Kaplowitz N. PMID: 7462234.
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    291. Glutathione-dependent thyroxine 5'-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells. Endocrinology. 1981 Mar; 108(3):970-6. Melmed S, Nelson M, Kaplowitz N, Yamada T, Hershman JM. PMID: 7460854.
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    292. Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice. J Clin Invest. 1981 Mar; 67(3):688-95. Yamada T, Ludwig S, Kuhlenkamp J, Kaplowitz N. PMID: 7204554; PMCID: PMC370618.
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    293. Extrahepatic obstruction in chronic alcoholic pancreatitis. Alcohol Clin Exp Res. 1981 Jan; 5(1):110-8. Afroudakis A, Kaplowitz N. PMID: 7013536.
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    294. Liver histopathology in chronic common bile duct stenosis due to chronic alcoholic pancreatitis. Hepatology. 1981 Jan-Feb; 1(1):65-72. Afroudakis A, Kaplowitz N. PMID: 7286890.
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    295. Physiological significance of glutathione S-transferases. Am J Physiol. 1980 Dec; 239(6):G439-44. Kaplowitz N. PMID: 7446736.
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    296. Effect of pyridoxine deficiency on serum and liver transaminases in experimental liver injury in the rat. Gastroenterology. 1980 Sep; 79(3):545-9. Ludwig S, Kaplowitz N. PMID: 7429115.
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    297. Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine. J Chromatogr. 1980 Jun 27; 194(3):424-8. Reeve J, Kuhlenkamp J, Kaplowitz N. PMID: 7391218.
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    298. Bile acid tolerance tests: rationale. Gastroenterology. 1980 Jun; 78(6):1654-5. Kaplowitz N. PMID: 7372082.
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    299. Inhibition of hepatic metabolism of azathioprine by furosemide in human liver in vitro. Biochem Pharmacol. 1980 May 15; 29(10):1439-41. von Bahr C, Glaumann H, Gudas J, Kaplowitz N. PMID: 7396978.
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    300. Propylthiouracil. A substrate for the glutathione S-transferases that competes with glutathione. J Biol Chem. 1980 Apr 25; 255(8):3508-13. Yamada T, Kaplowitz N. PMID: 7364753.
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    301. Binding of ethacrynic acid to hepatic glutathione S-transferases in vivo in the rat. Biochem Pharmacol. 1980 Apr 15; 29(8):1205-8. Yamada T, Kaplowitz N. PMID: 7387738.
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    302. Effect of salicylates and phenobarbital on hepatic glutathione in the rat. J Pharmacol Exp Ther. 1980 Feb; 212(2):240-5. Kaplowitz N, Kuhlenkamp J, Goldstein L, Reeve J. PMID: 7351635.
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    303. Common bile duct stenosis from chronic pancreatitis: a clinical and pathologic spectrum. Medicine (Baltimore). 1979 Nov; 58(6):385-412. Littenberg G, Afroudakis A, Kaplowitz N. PMID: 514065.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    304. Pruritus, cimetidine and polycythemia. N Engl J Med. 1979 02 22; 300(8):433-4. Harrison AR, Littenberg G, Goldstein L, Kaplowitz N. PMID: 366415.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    305. Significance of microscopic cholangitis in alcoholic liver disease. Gastroenterology. 1978 Dec; 75(6):1045-50. Afshani P, Littenberg GD, Wollman J, Kaplowitz N. PMID: 710856.
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    306. Aplastic anemia associated with type B viral hepatitis. Arch Intern Med. 1978 Oct; 138(10):1557-8. Casciato DA, Klein CA, Kaplowitz N, Scott JL. PMID: 708179.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    307. Cholestatic liver disease. Hosp Pract. 1978 Aug; 13(8):83-92. Kaplowitz N. PMID: 689682.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    308. Obstructive jaundice caused by hepatocellular carcinoma. Report of three cases. Am J Dig Dis. 1978 Jul; 23(7):609-17. Afroudakis A, Bhuta SM, Ranganath KA, Kaplowitz N. PMID: 210657.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    309. The effect of phenobarbital, probenecid and diethyl maleate on the pharmaco-kinetics and biliary excretion of ethacrynic acid in the rat. J Pharmacol Exp Ther. 1978 May; 205(2):471-9. Wallin JD, Clifton G, Kaplowitz N. PMID: 641842.
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    310. Glutathione S-transferase in human lymphoid cell lines and fractionated peripheral leucocytes. Biochem J. 1978 Mar 01; 169(3):465-70. Kaplowitz N, Spina C, Graham M, Kuhlenkamp J. PMID: 646786; PMCID: PMC1183818.
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    311. Effect of dietary phenobarbital, 3,4-benzo(alpha)pyrene and 3-methylcholanthrene on hepatic, intestinal and renal glutathione s-transferase activities in the rat. Biochem Pharmacol. 1978; 27(8):1284-7. Clifton G, Kaplowitz N. PMID: 697926.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    312. Inhibition of hepatic metabolism of azathioprine in vivo. Gastroenterology. 1978 Jan; 74(1):90-2. Kaplowitz N, Kuhlenkamp J. PMID: 618434.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    313. Endocrine and metabolic alterations with food and water deprivation. Am J Clin Nutr. 1977 Dec; 30(12):1953-62. Lee PA, Wallin JD, Kaplowitz N, Burkhartsmeier GL, Kane JP, Lewis SB. PMID: 412411.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    314. The glutathione S-transferases of the small intestine in the rat. Cancer Res. 1977 Mar; 37(3):788-91. Clifton G, Kaplowitz N. PMID: 837376.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    315. Interaction of azathioprine and glutathione in the liver of the rat. J Pharmacol Exp Ther. 1977 Mar; 200(3):479-86. Kaplowitz N. PMID: 850124.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    316. Metabolic clearance of furosemide in the rat. J Pharmacol Exp Ther. 1977 Jan; 200(1):52-7. Wallin JD, Ryals P, Kaplowitz N. PMID: 833762.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    317. Enzymatic thiolysis of azathioprine in vitro. Biochem Pharmacol. 1976 Nov 01; 25(21):2421-6. Kaplowitz N. PMID: 11807.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    318. Comparison of renal and hepatic glutathione S-transferases in the rat. Biochem J. 1976 Aug 15; 158(2):243-8. Kaplowitz N, Clifton G, Kuhlenkamp J, Wallin JD. PMID: 985425; PMCID: PMC1163965.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    319. Drug induction and sex differences of renal glutathione S-transferases in the rat. Biochem J. 1975 Aug; 150(2):259-62. Clifton G, Kaplowitz N, Wallin JD, Kuhlenkamp J. PMID: 1180917; PMCID: PMC1165733.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    320. Hepatic glutathione S-transferases: identification by gel filtration and in vitro inhibition by organic anions. Proc Soc Exp Biol Med. 1975 May; 149(1):234-7. Kaplowitz N, Kuhlenkamp J, Clifton G. PMID: 1144434.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    321. Drug induction of hepatic glutathione S-transferases in male and female rats*. Biochem J. 1975 Feb; 146(2):351-6. Kaplowitz N, Kuhlekamp J, Clifton G. PMID: 808217; PMCID: PMC1165312.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    322. Malabsorption secondary to mesenteric ischemia. Am J Roentgenol Radium Ther Nucl Med. 1973 Oct; 119(2):352-8. Meyers MA, Kaplowitz N, Bloom AA. PMID: 4748224.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    323. Role of hepatic anion-binding protein in bromsulphthalein conjugation. J Exp Med. 1973 Aug 01; 138(2):483-7. Kaplowitz N, Percy-Robb IW, Javitt NB. PMID: 4719680; PMCID: PMC2139406.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    324. Postprandial serum bile acid for the detection of hepatobiliary disease. JAMA. 1973 Jul 16; 225(3):292-3. Kaplowitz N, Kok E, Javitt NB. PMID: 4740377.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    325. Hepatobiliary diseases associated with serum antimitochondrial antibody (AMA). Am J Med. 1973 Jun; 54(6):725-30. Kaplowitz N, Finlayson ND, Walmsley P, Thurnherr N, Javitt NB. PMID: 4705417.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    326. Quantitative analysis of unconjugated and conjugated bile acids in duodenal fluid by densitometry after paper electrophoresis. J Lipid Res. 1973 Mar; 14(2):224-8. Kaplowitz N, Javitt NB. PMID: 4698269.
      View in: PubMed   Mentions:    Fields:    
    327. Coproporphyrin I and 3 excretion in bile and urine. J Clin Invest. 1972 Nov; 51(11):2895-9. Kaplowitz N, Javitt N, Kappas A. PMID: 5080415; PMCID: PMC292439.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    328. Isolation of erythrocytes with normal protoporphyrin levels in erythropoietic protoporphyria. N Engl J Med. 1968 May 16; 278(20):1077-81. Kaplowitz N, Javitt N, Harber LC. PMID: 5646228.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
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