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Keigo Machida, PhD

Title(s)Associate Professor of Molecular Microbiology & Immunology
AddressHMR 503C 2011 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 2692
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    Collapse Biography 
    Collapse Education and Training
    University of Tokyo, School of Medicine, Tokyo, JapanPh.D.03/2001Molecular Immunology
    University of Southern California, Los Angeles, CAPost-doc05/2003Molecular Virology
    Howard Hughes Medical Institute, Los Angeles, CAPost-doc08/2005Cancer Biology
    Collapse Awards and Honors
    Japan Society for the Promotion of Science1998  - 2001Scholarship
    Asian Pacific Association for the Study of the Liver (APASL)2007Young Investigator Award
    Research Center for Liver Diseases 2007  - 2007USC Research Center for Liver Diseases Pilot Funding Award
    Liver Meeting of AASLD2008Presidential Poster of Distinction
    American Cancer Society (ACS) 2011  - 2016Research Scholar

    Collapse Overview 
    Collapse Overview
    Hepatitis C Virus (HCV) is a “silent stalker” in infected people, who can develop hepatocellular carcinomas (HCC) decades later. Our short-term goal is to study three areas:

    (i) Host-pathogen interactions to identify the mechanism of HCV-associated HCC

    (ii) Molecular virology of lymphotropic HCV in viral persistence and pathogenesis

    (iii) Cancer biology in liver oncogenesis generated from tumor-initiating cells (TICs: “bad seeds” of treatment-resistant HCC) induced by interactions between environmental factors (alcohol, obesity) and HCV.

    Our lab’s long-term goal is to test new therapeutic modalities for HCC in HCV-infected patients with alcoholism and/or obesity.

    Our experience and resources on TICs have provided a unique opportunity to functionally dissect the alcohol-mediated self-renewal of liver TICs via TLR4 signaling. The p53 tumor suppressor acts as a barrier against stem cell proliferation, and inactivation of p53, or its stabilizing partner NUMB (cell fate decision molecule), leads to expansion of TICs. Although treatment efficacy of HCV has been dramatically improved in recent years, the incidence of HCV-associated HCC keeps rising due to the prevalence of obesity, alcoholism and illicit drug usage in HCV patients. Thus, we will continue our research on the development of new therapeutic modalities for HCC.

    Collapse Research 
    Collapse Research Activities and Funding
    LncRNA with MSI2 and super-enhancer in liver cancer stem cells induced by alcohol
    NIH/NIAAA R21AA025470Sep 15, 2018 - Aug 31, 2020
    Role: Principal Investigator
    NANOG-positive cancer stem cells in liver oncogenesis induced by alcohol and HCV
    NIH/NIAAA R01AA025204Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Southern California Research Center for ALPD and Cirrhosis
    NIH/NIAAA P50 AA11999Jan 1, 2015 - Dec 31, 2019
    Role: Co-director of Animal Core Facility and Project 3 leader
    Role Description: This center grant supports our central research theme: elucidation of mechanisms by which alcohol sensitizes and primes the liver and pancreas for injury. Animal Core provides the intragastric ethanol infusion model to the Center members.
    Nanog-positive cancer stem cells in and liver oncogenesis by alcohol and HCV
    NIH/NIAAA R01AA018857Sep 15, 2009 - Aug 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs. Nat Commun. 2020 06 17; 11(1):3084. Choi HY, Siddique HR, Zheng M, Kou Y, Yeh DW, Machida T, Chen CL, Uthaya Kumar DB, Punj V, Winer P, Pita A, Sher L, Tahara SM, Ray RB, Liang C, Chen L, Tsukamoto H, Machida K. PMID: 32555153.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Cell fate, metabolic reprogramming and lncRNA of tumor-initiating stem-like cells induced by alcohol. Chem Biol Interact. 2020 May 25; 323:109055. Machida K. PMID: 32171851.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance. Nat Commun. 2019 04 12; 10(1):1693. Li S, Song Y, Quach C, Guo H, Jang GB, Maazi H, Zhao S, Sands NA, Liu Q, In GK, Peng D, Yuan W, Machida K, Yu M, Akbari O, Hagiya A, Yang Y, Punj V, Tang L, Liang C. PMID: 30979895.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance. J Virol. 2019 04 15; 93(8). Bang BR, Li M, Tsai KN, Aoyagi H, Lee SA, Machida K, Aizaki H, Jung JU, Ou JJ, Saito T. PMID: 30728260.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Pluripotency Transcription Factors and Metabolic Reprogramming of Mitochondria in Tumor-Initiating Stem-like Cells. Antioxid Redox Signal. 2018 Apr 10; 28(11):1080-1089. Machida K. PMID: 29256636.
      View in: PubMed   Mentions: 2     Fields:    
    6. NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells. Adv Exp Med Biol. 2018; 1032:105-113. Machida K. PMID: 30362094.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells. Mol Cell. 2017 Oct 19; 68(2):281-292.e5. Liu K, Lee J, Kim JY, Wang L, Tian Y, Chan ST, Cho C, Machida K, Chen D, Ou JJ. PMID: 29033320.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    8. The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol. 2018 04; 14:164-177. Baulies A, Montero J, Matías N, Insausti N, Terrones O, Basañez G, Vallejo C, Conde de La Rosa L, Martinez L, Robles D, Morales A, Abian J, Carrascal M, Machida K, Kumar DBU, Tsukamoto H, Kaplowitz N, Garcia-Ruiz C, Fernández-Checa JC. PMID: 28942194.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Wnt/ß-catenin activation and macrophage induction during liver cancer development following steatosis. Oncogene. 2017 10 26; 36(43):6020-6029. Debebe A, Medina V, Chen CY, Mahajan IM, Jia C, Fu D, He L, Zeng N, Stiles BW, Chen CL, Wang M, Aggarwal KR, Peng Z, Huang J, Chen J, Li M, Dong T, Atkins S, Borok Z, Yuan W, Machida K, Ju C, Kahn M, Johnson D, Stiles BL. PMID: 28671671.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2. Nat Commun. 2017 01 09; 8:13882. Chen CL, Huang JY, Wang CH, Tahara SM, Zhou L, Kondo Y, Schechter J, Su L, Lai MM, Wakita T, Cosset FL, Jung JU, Machida K. PMID: 28067225.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Loss of the transforming growth factor-ß effector ß2-Spectrin promotes genomic instability. Hepatology. 2017 02; 65(2):678-693. Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, Davila M, Nguyen BN, Stroehlein JR, Chen J, Kim SS, Levin H, Machida K, Tsukamoto H, Michaely P, Tzatsos A, Mishra B, Amdur R, Mishra L. PMID: 28114741.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Existence of cancer stem cells in hepatocellular carcinoma: myth or reality? Hepatol Int. 2017 Mar; 11(2):143-147. Machida K. PMID: 27990610.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. TGF-ß/ß2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest. 2016 Feb; 126(2):527-42. Chen J, Yao ZX, Chen JS, Gi YJ, Muñoz NM, Kundra S, Herlong HF, Jeong YS, Goltsov A, Ohshiro K, Mistry NA, Zhang J, Su X, Choufani S, Mitra A, Li S, Mishra B, White J, Rashid A, Wang AY, Javle M, Davila M, Michaely P, Weksberg R, Hofstetter WL, Finegold MJ, Shay JW, Machida K, Tsukamoto H, Mishra L. PMID: 26784546.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism. Cell Metab. 2016 Jan 12; 23(1):206-19. Chen CL, Uthaya Kumar DB, Punj V, Xu J, Sher L, Tahara SM, Hess S, Machida K. PMID: 26724859.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    15. TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice. Gastroenterology. 2016 Mar; 150(3):707-19. Uthaya Kumar DB, Chen CL, Liu JC, Feldman DE, Sher LS, French S, DiNorcia J, French SW, Naini BV, Junrungsee S, Agopian VG, Zarrinpar A, Machida K. PMID: 26582088.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    16. NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer. Hepatology. 2015 Nov; 62(5):1466-79. Siddique HR, Feldman DE, Chen CL, Punj V, Tokumitsu H, Machida K. PMID: 26174965.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015 Aug 03; 6:7839. He S, Zhao Z, Yang Y, O'Connell D, Zhang X, Oh S, Ma B, Lee JH, Zhang T, Varghese B, Yip J, Dolatshahi Pirooz S, Li M, Zhang Y, Li GM, Ellen Martin S, Machida K, Liang C. PMID: 26234763.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma. Clin Sci (Lond). 2015 Jun; 128(11):761-74. Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, Weiss TS, Ruemmele P, Kollmar O, Hoffmann P, Grässer F, Allgayer H, Fabian J, Weng HL, Teufel A, Maass T, Meyer C, Lehmann U, Zhu C, Mertens PR, Gao CF, Dooley S, Meindl-Beinker NM. PMID: 25602745.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis. Adv Exp Med Biol. 2015; 815:131-44. Machida K, Feldman DE, Tsukamoto H. PMID: 25427905.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology. 2015 Jan; 61(1):129-40. Lazaro R, Wu R, Lee S, Zhu NL, Chen CL, French SW, Xu J, Machida K, Tsukamoto H. PMID: 25132354.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    21. Iterative tyrosine phosphorylation controls non-canonical domain utilization in Crk. Oncogene. 2015 Aug 06; 34(32):4260-9. Sriram G, Jankowski W, Kasikara C, Reichman C, Saleh T, Nguyen KQ, Li J, Hornbeck P, Machida K, Liu T, Li H, Kalodimos CG, Birge RB. PMID: 25381819.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure. FEBS Open Bio. 2014; 4:777-87. Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M. PMID: 25349782.
      View in: PubMed   Mentions: 35     Fields:    
    23. Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity. Oncogene. 2015 May 14; 34(20):2650-9. Ng KY, Yin T, Machida K, Wu YI, Mayer BJ. PMID: 25043303.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. Hepatol Int. 2014 Jul; 8(3):330-8. Chen CL, Tsukamoto H, Machida K. PMID: 26202636.
      View in: PubMed   Mentions: 4     Fields:    
    25. HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases. PLoS One. 2014; 9(6):e98521. Kondo Y, Ninomiya M, Kimura O, Machida K, Funayama R, Nagashima T, Kobayashi K, Kakazu E, Kato T, Nakayama K, Lai MM, Shimosegawa T. PMID: 24905921.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    26. Alcohol, TLR4-TGF-ß antagonism, and liver cancer. Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. Tsukamoto H, Mishra L, Machida K. PMID: 26201318.
      View in: PubMed   Mentions: 2     Fields:    
    27. Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells. J Clin Invest. 2013 Jul; 123(7):2832-49. Chen CL, Tsukamoto H, Liu JC, Kashiwabara C, Feldman D, Sher L, Dooley S, French SW, Mishra L, Petrovic L, Jeong JH, Machida K. PMID: 23921128.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    28. Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus. Drug Deliv Transl Res. 2013 Apr; 3(2):152-64. Machida K. PMID: 25787983.
      View in: PubMed   Mentions:    Fields:    
    29. The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex. PLoS One. 2013; 8(2):e57312. Feldman DE, Chen C, Punj V, Machida K. PMID: 23468968.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. PPARs and Liver Disease. PPAR Res. 2013; 2013:896412. Kondo Y, Uno K, Machida K, Terajima M. PMID: 23476632.
      View in: PubMed   Mentions:
    31. A super TLR agonist to improve efficacy of dendritic cell vaccine in induction of anti-HCV immunity. PLoS One. 2012; 7(11):e48614. Hong B, Lee SH, Song XT, Jones L, Machida K, Huang XF, Chen SY. PMID: 23144910.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    32. Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry. J Biol Chem. 2012 Dec 07; 287(50):41922-30. Liu Z, Tian Y, Machida K, Lai MM, Luo G, Foung SK, Ou JH. PMID: 23095753.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    33. Hepatitis C virus translation preferentially depends on active RNA replication. PLoS One. 2012; 7(8):e43600. Liu HM, Aizaki H, Machida K, Ou JH, Lai MM. PMID: 22937067.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9. von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. PMID: 22687340.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    35. Replication of hepatitis C virus RNA on autophagosomal membranes. J Biol Chem. 2012 May 25; 287(22):18036-43. Sir D, Kuo CF, Tian Y, Liu HM, Huang EJ, Jung JU, Machida K, Ou JH. PMID: 22496373.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    36. Mouse intragastric infusion (iG) model. Nat Protoc. 2012 Mar 29; 7(4):771-81. Ueno A, Lazaro R, Wang PY, Higashiyama R, Machida K, Tsukamoto H. PMID: 22461066.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    37. Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. Machida K, Chen CL, Liu JC, Kashiwabara C, Feldman D, French SW, Sher L, Hyeongnam JJ, Tsukamoto H. PMID: 22320911.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    38. Morphogens and hepatic stellate cell fate regulation in chronic liver disease. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. Tsukamoto H, Zhu NL, Wang J, Asahina K, Machida K. PMID: 22320925.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    39. Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. Feldman DE, Chen C, Punj V, Tsukamoto H, Machida K. PMID: 22207628.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    40. Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. J Virol. 2011 Oct; 85(20):10899-904. Inn KS, Lee SH, Rathbun JY, Wong LY, Toth Z, Machida K, Ou JH, Jung JU. PMID: 21835791.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    41. Hepatitis C virus-related lymphomagenesis in a mouse model. ISRN Hematol. 2011; 2011:167501. Tsukiyama-Kohara K, Sekiguchi S, Kasama Y, Salem NE, Machida K, Kohara M. PMID: 22084693.
      View in: PubMed   Mentions:
    42. Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation. Oncogene. 2011 Nov 17; 30(46):4645-55. Sriram G, Reichman C, Tunceroglu A, Kaushal N, Saleh T, Machida K, Mayer B, Ge Q, Li J, Hornbeck P, Kalodimos CG, Birge RB. PMID: 21602891.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    43. Toll-like receptor signaling in liver diseases. Gastroenterol Res Pract. 2010; 2010:971270. Szabo G, Billiar TR, Machida K, Crispe IN, Seki E. PMID: 21789039.
      View in: PubMed   Mentions:
    44. TLRs, Alcohol, HCV, and Tumorigenesis. Gastroenterol Res Pract. 2010; 2010:518674. Machida K. PMID: 21331379.
      View in: PubMed   Mentions:
    45. Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011 Jan 28; 286(4):2393-401. Zhong S, Machida K, Tsukamoto H, Johnson DL. PMID: 21106530.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    46. Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 2010 Dec 01; 185(11):6985-98. Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. PMID: 20974981.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    47. Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem. 2010 Nov 12; 285(46):35359-73. Yeligar SM, Machida K, Kalra VK. PMID: 20833713.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    48. Hepatitis C virus egress and release depend on endosomal trafficking of core protein. J Virol. 2010 Nov; 84(21):11590-8. Lai CK, Jeng KS, Machida K, Lai MM. PMID: 20739534.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    49. Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation. Oncogene. 2010 Dec 02; 29(48):6378-89. Zheng J, Machida K, Antoku S, Ng KY, Claffey KP, Mayer BJ. PMID: 20729917.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    50. Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-? secretion activity. J Gastroenterol. 2011 Feb; 46(2):232-41. Kondo Y, Ueno Y, Kakazu E, Kobayashi K, Shiina M, Tamai K, Machida K, Inoue J, Wakui Y, Fukushima K, Obara N, Kimura O, Shimosegawa T. PMID: 20714907.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    51. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2010 Aug; 52(2):480-92. Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. PMID: 20683948.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    52. Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A. J Virol. 2010 Aug; 84(16):7983-93. Chen YC, Su WC, Huang JY, Chao TC, Jeng KS, Machida K, Lai MM. PMID: 20534861.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    53. Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage. Alcohol Clin Exp Res. 2010 Oct; 34(10):1675-86. Szabo G, Wands JR, Eken A, Osna NA, Weinman SA, Machida K, Joe Wang H. PMID: 20608905.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    54. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009 Nov 01; 183(9):5964-76. Yeligar SM, Machida K, Tsukamoto H, Kalra VK. PMID: 19828633.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    55. Hepatitis C virus causes uncoupling of mitotic checkpoint and chromosomal polyploidy through the Rb pathway. J Virol. 2009 Dec; 83(23):12590-600. Machida K, Liu JC, McNamara G, Levine A, Duan L, Lai MM. PMID: 19793824.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    56. "Second hit" models of alcoholic liver disease. Semin Liver Dis. 2009 May; 29(2):178-87. Tsukamoto H, Machida K, Dynnyk A, Mkrtchyan H. PMID: 19387917.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    57. Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins. Gastroenterology. 2009 Jul; 137(1):285-96, 296.e1-11. Machida K, Tsukiyama-Kohara K, Sekiguch S, Seike E, Tóne S, Hayashi Y, Tobita Y, Kasama Y, Shimizu M, Takahashi H, Taya C, Yonekawa H, Tanaka N, Kohara M. PMID: 19362089.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    58. Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6. J Infect Dis. 2009 Mar 01; 199(5):726-36. Kondo Y, Machida K, Liu HM, Ueno Y, Kobayashi K, Wakita T, Shimosegawa T, Lai MM. PMID: 19199548.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    59. SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication. Virology. 2009 Apr 10; 386(2):249-56. Liu HM, Aizaki H, Choi KS, Machida K, Ou JJ, Lai MM. PMID: 19232660.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    60. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. PMID: 19171902.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    61. Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A. J Virol. 2008 Sep; 82(17):8838-48. Lai CK, Jeng KS, Machida K, Lai MM. PMID: 18562541.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    62. Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein. J Virol. 2008 Jul; 82(13):6711-20. Machida K, Kondo Y, Huang JY, Chen YC, Cheng KT, Keck Z, Foung S, Dubuisson J, Sung VM, Lai MM. PMID: 18417597.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    63. Bulk electronic structure of the antiferromagnetic superconducting phase in ErNi2B2C. Phys Rev Lett. 2008 Jan 11; 100(1):017003. Baba T, Yokoya T, Tsuda S, Kiss T, Shimojima T, Ishizaka K, Takeya H, Hirata K, Watanabe T, Nohara M, Takagi H, Nakai N, Machida K, Togashi T, Watanabe S, Wang XY, Chen CT, Shin S. PMID: 18232808.
      View in: PubMed   Mentions:    Fields:    
    64. Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies. Curr Top Microbiol Immunol. 2008; 317:1-38. Keck ZY, Machida K, Lai MM, Ball JK, Patel AH, Foung SK. PMID: 17990788.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    65. Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation. Virology. 2008 Jan 20; 370(2):295-309. Lai CK, Jeng KS, Machida K, Cheng YS, Lai MM. PMID: 17931678.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    66. Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines. Virology. 2007 Apr 25; 361(1):161-73. Kondo Y, Sung VM, Machida K, Liu M, Lai MM. PMID: 17175001.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    67. HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice. Hepatology. 2006 Oct; 44(4):936-44. Kawamura H, Govindarajan S, Aswad F, Machida K, Lai MM, Sung VM, Dennert G. PMID: 17006910.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    68. Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J Virol. 2006 Jul; 80(14):7199-207. Machida K, Cheng KT, Lai CK, Jeng KS, Sung VM, Lai MM. PMID: 16809325.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    69. Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol. 2006 Jan; 80(2):866-74. Machida K, Cheng KT, Sung VM, Levine AM, Foung S, Lai MM. PMID: 16378988.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    70. Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells. J Virol. 2005 Jul; 79(13):8079-89. Machida K, Cheng KT, Pavio N, Sung VM, Lai MM. PMID: 15956553.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    71. Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes. J Virol. 2004 Aug; 78(16):8835-43. Machida K, Cheng KT, Sung VM, Lee KJ, Levine AM, Lai MM. PMID: 15280491.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    72. Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4262-7. Machida K, Cheng KT, Sung VM, Shimodaira S, Lindsay KL, Levine AM, Lai MY, Lai MM. PMID: 14999097.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    73. Cynomolgus monkey did not hyperacutely reject skin xenograft of N-acetylglucosaminyltransferase III gene transgenic pig. Transplant Proc. 2003 Feb; 35(1):518. Fujita T, Machida K, Matsumoto Y, Saito T, Sato N, Takahagi Y, Murakami H, Miyagawa S, Shirakura R, Taniguchi N. PMID: 12591511.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    74. Secoiridoid glycosides from Gentiana scabra. J Nat Prod. 2001 Dec; 64(12):1574-5. Kakuda R, Iijima T, Yaoita Y, Machida K, Kikuchi M. PMID: 11754617.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    75. Intranephron localization and regulation of the V1a vasopressin receptor during chronic metabolic acidosis and dehydration in rats. Pflugers Arch. 2001 Aug; 442(5):652-61. Tashima Y, Kohda Y, Nonoguchi H, Ikebe M, Machida K, Star RA, Tomita K. PMID: 11512020.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    76. Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner. Mol Biol Cell. 2001 Jun; 12(6):1859-68. Sohara Y, Ishiguro N, Machida K, Kurata H, Thant AA, Senga T, Matsuda S, Kimata K, Iwata H, Hamaguchi M. PMID: 11408591.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    77. Studies on the constituents of Catalpa species. VI. Monoterpene glycosides from the fallen leaves of Catalpa ovata G. Don. Chem Pharm Bull (Tokyo). 2001 Jun; 49(6):732-6. Machida K, Ando M, Yaoita Y, Kakuda R, Kikuchi M. PMID: 11411526.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    78. New sterols and triterpenoids from four edible mushrooms. Chem Pharm Bull (Tokyo). 2001 May; 49(5):589-94. Yaoita Y, Matsuki K, Iijima T, Nakano S, Kakuda R, Machida K, Kikuchi M. PMID: 11383612.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    79. Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins. J Biol Chem. 2001 Apr 13; 276(15):12140-6. Machida K, Tsukiyama-Kohara K, Seike E, Toné S, Shibasaki F, Shimizu M, Takahashi H, Hayashi Y, Funata N, Taya C, Yonekawa H, Kohara M. PMID: 11278624.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    80. Secoiridoid glycosides from the flower buds of Lonicera japonica. Phytochemistry. 2000 Dec; 55(8):879-81. Kakuda R, Imai M, Yaoita Y, Machida K, Kikuchi M. PMID: 11140518.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    81. Structures of new ceramides from the fruit bodies of Grifola frondosa. Chem Pharm Bull (Tokyo). 2000 Sep; 48(9):1356-8. Yaoita Y, Ishizuka T, Kakuda R, Machida K, Kikuchi M. PMID: 10993238.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    82. Protective effects of alpha-tocopherol and beta-carotene on para-nonylphenol-induced inhibition of cell growth, cellular respiration and glucose-induced proton extrusion of bacteria. FEMS Microbiol Lett. 2000 Jun 15; 187(2):161-5. Okai Y, Higashi-Okai K, Machida K, Nakamura H, Nakayama K, Fijita K, Tanaka T, Taniguchi M. PMID: 10856651.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    83. Studies of the constituents of Gardenia species. II. Terpenoids from Gardeniae Fructus. Chem Pharm Bull (Tokyo). 2000 May; 48(5):746-8. Machida K, Oyama K, Ishii M, Kakuda R, Yaoita Y, Kikuchi M. PMID: 10823717.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    84. Protective effect of antioxidants against para-nonylphenol-induced inhibition of cell growth in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2000 Apr 01; 185(1):65-70. Okai Y, Higashi-Okai K, Machida K, Nakamura H, Nakayama K, Fujita K, Tanaka T, Otani S, Taniguchi M. PMID: 10731608.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    85. v-Src suppresses SHPS-1 expression via the Ras-MAP kinase pathway to promote the oncogenic growth of cells. Oncogene. 2000 Mar 23; 19(13):1710-8. Machida K, Matsuda S, Yamaki K, Senga T, Thant AA, Kurata H, Miyazaki K, Hayashi K, Okuda T, Kitamura T, Hayakawa T, Hamaguchi M. PMID: 10763828.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    86. Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A. Oncogene. 2000 Jan 13; 19(2):273-9. Senga T, Miyazaki K, Machida K, Iwata H, Matsuda S, Nakashima I, Hamaguchi M. PMID: 10645006.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    87. Farnesol-induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F(0)F(1)-ATPase in yeast. FEBS Lett. 1999 Nov 26; 462(1-2):108-12. Machida K, Tanaka T. PMID: 10580101.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    88. Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1. Oncogene. 1999 Nov 11; 18(47):6555-63. Thant AA, Sein TT, Liu E, Machida K, Kikkawa F, Koike T, Seiki M, Matsuda S, Hamaguchi M. PMID: 10597259.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    89. Lung cancer in patients who had received thoracoplasty for pulmonary tuberculosis. Jpn J Clin Oncol. 1999 Nov; 29(11):541-5. Tamura A, Hebisawa A, Hayashi K, Sagara Y, Kawabe Y, Nagayama N, Machida K, Fukushima K, Yotsumoto H, Mori M. PMID: 10678556.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    90. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. IV. Comparative studies of UK-2A with antimycin A3 on cytotoxic activity and reactive oxygen species generation in LLC-PK1 cells. J Antibiot (Tokyo). 1999 May; 52(5):480-4. Takimoto H, Machida K, Ueki M, Tanaka T, Taniguchi M. PMID: 10480572.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    91. Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae. J Bacteriol. 1998 Sep; 180(17):4460-5. Machida K, Tanaka T, Fujita K, Taniguchi M. PMID: 9721283.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    92. Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA. Virology. 1997 Oct 27; 237(2):270-82. Kumar PK, Machida K, Urvil PT, Kakiuchi N, Vishnuvardhan D, Shimotohno K, Taira K, Nishikawa S. PMID: 9356339.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    93. [Diagnostic accuracy of 201T1 SPECT.MRI in brain diseases and inter-reader variance of diagnostic performance]. Kaku Igaku. 1996 Sep; 33(9):943-52. Machida K, Honda N, Matsumoto T, Yui N, Togawa T, Kubo A, Tsukatani Y, Oyamada H, Ishii K, Nishimaki H, Mori Y, Uno K, Murata H, Maruno H. PMID: 8921662.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    94. Dietary analysis of Japanese patients with chronic pancreatitis in stable conditions. J Gastroenterol. 1994 Dec; 29(6):756-62. Nakamura T, Arai Y, Terada A, Kudoh K, Imamura K, Machida K, Kikuchi H, Takebe K. PMID: 7874272.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    95. Seasonal development of Leptotrombidium pallidum (Acari: Trombiculidae) observed by experimental rearing in the natural environment. J Med Entomol. 1993 Mar; 30(2):320-5. Takahashi M, Machida K, Murata M, Misumi H, Hori E, Kawamura A, Tanaka H. PMID: 8459408.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    96. Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit. Biochem Int. 1992 Sep; 27(6):1051-7. Sudo K, Maekawa M, Shioya M, Ikeda K, Takahashi N, Isogai Y, Li SS, Kanno T, Machida K, Toriumi J. PMID: 1445373.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    97. Aggregated distribution of infective spots composed of Leptotrombidium pallidum, highly prevalent with Rickettsia tsutsugamushi, demonstrated by sentinel voles, Microtus montebelli, on the ground. Jpn J Exp Med. 1990 Dec; 60(6):325-35. Takahashi M, Murata M, Machida K, Hori E, Kawamura A, Tanaka H. PMID: 2128945.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    98. A missense mutation found in human lactate dehydrogenase-B (H) variant gene. Biochem Biophys Res Commun. 1990 Apr 30; 168(2):672-6. Sudo K, Maekawa M, Ikawa S, Machida K, Kitamura M, Li SS. PMID: 2334429.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
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