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Jing-Hsiung James Ou, PhD

TitleProfessor of Molecular Microbiology & Immunology
InstitutionUniversity of Southern California
DepartmentMolecular Microbiology and Immunology
AddressHMR 402A 2011 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 1720
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    Collapse Biography 
    Collapse Education and Training
    National Taiwan University, TaiwanB.S.06/1976Zoology
    California Institute of Technology, Pasadena, CaliforniaPh.D.06/1982Molecular Virology

    Collapse Overview 
    Collapse Overview
    The research of our laboratory is centered on hepatitis B virus (HBV), hepatitis C virus (HCV), and liver cancer. We are particularly interested in understanding how these two viruses interact with their host cells, how they invaded host immunity to establish persistent infection, and how they cause liver diseases including hepatocellular carcinoma.


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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tian Y, Ou JJ. Partial Hepatectomy and Castration of HBV Transgenic Mice. Methods Mol Biol. 2017; 1540:259-266. PMID: 27975324.
      View in: PubMed
    2. Chan ST, Lee J, Narula M, Ou JJ. Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6. J Virol. 2016 Dec 01; 90(23):10928-10935. PMID: 27681126.
      View in: PubMed
    3. Tian Y, Kuo CF, Akbari O, Ou JH. Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016 05 17; 44(5):1204-14. PMID: 27156385; PMCID: PMC4871724 [Available on 05/17/17].
    4. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    5. Wang L, Ou JH. Hepatitis C virus and autophagy. Biol Chem. 2015 Nov; 396(11):1215-22. PMID: 26024249; PMCID: PMC4778564 [Available on 11/01/16].
    6. Lee J, Tian Y, Chan ST, Kim JY, Cho C, Ou JH. TNF-a Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism. PLoS Pathog. 2015 May; 11(5):e1004937. PMID: 26023919; PMCID: PMC4449221.
    7. Tian Y, Ou JH. Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma. Virol Sin. 2015 Apr; 30(2):85-91. PMID: 25862579.
      View in: PubMed
    8. Luo GG, Ou JH. Oncogenic viruses and cancer. Virol Sin. 2015 Apr; 30(2):83-4. PMID: 25924992; PMCID: PMC4731227.
    9. Wang L, Tian Y, Ou JH. HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. PLoS Pathog. 2015 Mar; 11(3):e1004764. PMID: 25807108; PMCID: PMC4373777.
    10. Slagle BL, Andrisani OM, Bouchard MJ, Lee CG, Ou JH, Siddiqui A. Technical standards for hepatitis B virus X protein (HBx) research. Hepatology. 2015 Apr; 61(4):1416-24. PMID: 25099228; PMCID: PMC4320676.
    11. Tian Y, Wang L, Ou JH. Autophagy, a double-edged sword in hepatocarcinogenesis. Mol Cell Oncol. 2015 Oct-Dec; 2(4):e1004968. PMID: 27308502; PMCID: PMC4905348.
    12. Tian Y, Kuo CF, Sir D, Wang L, Govindarajan S, Petrovic LM, Ou JH. Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis. Cell Death Differ. 2015 Jun; 22(6):1025-34. PMID: 25526090; PMCID: PMC4423188.
    13. Ou JH. Virus control goes epigenetic. PLoS Pathog. 2014 Sep; 10(9):e1004370. PMID: 25211140; PMCID: PMC4161466.
    14. Czaja MJ, Ding WX, Donohue TM, Friedman SL, Kim JS, Komatsu M, Lemasters JJ, Lemoine A, Lin JD, Ou JH, Perlmutter DH, Randall G, Ray RB, Tsung A, Yin XM. Functions of autophagy in normal and diseased liver. Autophagy. 2013 Aug; 9(8):1131-58. PMID: 23774882; PMCID: PMC3748187.
    15. Liu Z, Tian Y, Machida K, Lai MM, Luo G, Foung SK, Ou JH. Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry. J Biol Chem. 2012 Dec 07; 287(50):41922-30. PMID: 23095753; PMCID: PMC3516739.
    16. Liu HM, Aizaki H, Machida K, Ou JH, Lai MM. Hepatitis C virus translation preferentially depends on active RNA replication. PLoS One. 2012; 7(8):e43600. PMID: 22937067; PMCID: PMC3427374.
    17. Tian Y, Chen WL, Kuo CF, Ou JH. Viral-load-dependent effects of liver injury and regeneration on hepatitis B virus replication in mice. J Virol. 2012 Sep; 86(18):9599-605. PMID: 22718822; PMCID: PMC3446606.
    18. Wang Q, Na B, Ou JH, Pulliam L, Yen TS. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One. 2012; 7(5):e36818. PMID: 22606292; PMCID: PMC3350475.
    19. Mo RH, Zaro JL, Ou JH, Shen WC. Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells. Mol Biotechnol. 2012 May; 51(1):1-8. PMID: 21660602.
      View in: PubMed
    20. Sir D, Kuo CF, Tian Y, Liu HM, Huang EJ, Jung JU, Machida K, Ou JH. Replication of hepatitis C virus RNA on autophagosomal membranes. J Biol Chem. 2012 May 25; 287(22):18036-43. PMID: 22496373; PMCID: PMC3365724.
    21. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
      View in: PubMed
    22. Tian Y, Kuo CF, Chen WL, Ou JH. Enhancement of hepatitis B virus replication by androgen and its receptor in mice. J Virol. 2012 Feb; 86(4):1904-10. PMID: 22156518; PMCID: PMC3302417.
    23. Sun J, Desai MM, Soong L, Ou JH. IFN-a/ß and autophagy: tug-of-war between HCV and the host. Autophagy. 2011 Nov; 7(11):1394-6. PMID: 21997372; PMCID: PMC3359484.
    24. Na B, Huang Z, Wang Q, Qi Z, Tian Y, Lu CC, Yu J, Hanes MA, Kakar S, Huang EJ, Ou JH, Liu L, Yen TS. Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury. PLoS One. 2011; 6(10):e26240. PMID: 22022578; PMCID: PMC3192172.
    25. Tian Y, Sir D, Kuo CF, Ann DK, Ou JH. Autophagy required for hepatitis B virus replication in transgenic mice. J Virol. 2011 Dec; 85(24):13453-6. PMID: 21957292; PMCID: PMC3233133.
    26. Inn KS, Lee SH, Rathbun JY, Wong LY, Toth Z, Machida K, Ou JH, Jung JU. Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. J Virol. 2011 Oct; 85(20):10899-904. PMID: 21835791; PMCID: PMC3187500.
    27. Kido T, Ou JH, Lau YF. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PLoS One. 2011; 6(7):e22979. PMID: 21829568; PMCID: PMC3146538.
    28. Tian Y, Chen WL, Ou JH. Effects of interferon-a/ß on HBV replication determined by viral load. PLoS Pathog. 2011 Jul; 7(7):e1002159. PMID: 21829354; PMCID: PMC3145790.
    29. Zhou J, Tan T, Tian Y, Zheng B, Ou JH, Huang EJ, Yen TS. Krüppel-like factor 15 activates hepatitis B virus gene expression and replication. Hepatology. 2011 Jul; 54(1):109-21. PMID: 21503941.
      View in: PubMed
    30. Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 2010 Dec 01; 185(11):6985-98. PMID: 20974981; PMCID: PMC3101474.
    31. Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2010 Aug; 52(2):480-92. PMID: 20683948; PMCID: PMC3107125.
    32. Zhang Z, Sun E, Ou JH, Liang TJ. Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo. J Virol. 2010 Sep; 84(18):9326-31. PMID: 20592087; PMCID: PMC2937595.
    33. Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, Ryan CK, Hung YC, Yeh S, Chang C. Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med. 2010 May 19; 2(32):32ra35. PMID: 20484730; PMCID: PMC3032595.
    34. Sir D, Ann DK, Ou JH. Autophagy by hepatitis B virus and for hepatitis B virus. Autophagy. 2010 May; 6(4):548-9. PMID: 20305390.
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    35. Sir D, Tian Y, Chen WL, Ann DK, Yen TS, Ou JH. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4383-8. PMID: 20142477; PMCID: PMC2840127.
    36. Sir D, Ou JH. Autophagy in viral replication and pathogenesis. Mol Cells. 2010 Jan; 29(1):1-7. PMID: 20077024; PMCID: PMC3115743.
    37. Chen JL, Lin HH, Kim KJ, Lin A, Ou JH, Ann DK. PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis. Autophagy. 2009 Feb; 5(2):244-6. PMID: 19098423; PMCID: PMC2743529.
    38. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. PMID: 19171902; PMCID: PMC2635765.
    39. Yuksek K, Chen WL, Chien D, Ou JH. Ubiquitin-independent degradation of hepatitis C virus F protein. J Virol. 2009 Jan; 83(2):612-21. PMID: 18971267; PMCID: PMC2612388.
    40. Sir D, Chen WL, Choi J, Wakita T, Yen TS, Ou JH. Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology. 2008 Oct; 48(4):1054-61. PMID: 18688877; PMCID: PMC2562598.
    41. Sir D, Liang C, Chen WL, Jung JU, Ou JH. Perturbation of autophagic pathway by hepatitis C virus. Autophagy. 2008 Aug; 4(6):830-1. PMID: 18635950; PMCID: PMC2574555.
    42. Liang C, Sir D, Lee S, Ou JH, Jung JU. Beyond autophagy: the role of UVRAG in membrane trafficking. Autophagy. 2008 Aug; 4(6):817-20. PMID: 18612260; PMCID: PMC2878715.
    43. Ma HC, Lin TW, Li H, Iguchi-Ariga SM, Ariga H, Chuang YL, Ou JH, Lo SY. Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc. J Biomed Sci. 2008 Jul; 15(4):417-25. PMID: 18398700.
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    44. Zheng Y, Chen WL, Ma WL, Chang C, Ou JH. Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein. Virology. 2007 Jul 05; 363(2):454-61. PMID: 17335866; PMCID: PMC1976269.
    45. Zheng Y, Chen WL, Louie SG, Yen TS, Ou JH. Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology. 2007 Jan; 45(1):16-21. PMID: 17187428.
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    46. Choi J, Forman HJ, Ou JH, Lai MM, Seronello S, Nandipati A. Redox modulation of the hepatitis C virus replication complex is calcium dependent. Free Radic Biol Med. 2006 Nov 01; 41(9):1488-98. PMID: 17023276.
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    47. Jiang QC, Tong DY, Sun HY, Ou JH, Chen LX, Wu XY. [Genetics of heteroplasmy in the mtDNA control region among the Chinese Han population]. Fa Yi Xue Za Zhi. 2006 Jun; 22(3):198-203. PMID: 16856343.
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    48. Choi J, Ou JH. Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G847-51. PMID: 16603728.
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    49. Zheng Y, Fu XD, Ou JH. Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein. Virology. 2005 Nov 10; 342(1):150-8. PMID: 16122776.
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    50. Zheng Y, Li J, Ou JH. Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein. J Virol. 2004 Jul; 78(13):6908-14. PMID: 15194767; PMCID: PMC421633.
    51. Lee KJ, Choi J, Ou JH, Lai MM. The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo. J Virol. 2004 Apr; 78(7):3797-802. PMID: 15016899; PMCID: PMC371049.
    52. Xu Z, Ou JH. Endogenous polymerase assay for the analysis of hepatitis B virus in transgenic mice. Methods Mol Med. 2004; 95:295-302. PMID: 14762312.
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    53. Choi J, Lee KJ, Zheng Y, Yamaga AK, Lai MM, Ou JH. Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells. Hepatology. 2004 Jan; 39(1):81-9. PMID: 14752826.
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    54. Li J, Zheng Y, Choi J, Ou JH. Phosphorylation analysis of hepatitis B virus core protein in mammalian cells. Methods Mol Med. 2004; 95:227-33. PMID: 14762306.
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    55. Liu N, Zhang T, Wang YJ, Huang YP, Ou JH, Shen P. A heat inducible tyrosinase with distinct properties from Bacillus thuringiensis. Lett Appl Microbiol. 2004; 39(5):407-12. PMID: 15482430.
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    56. Ou JH, Xie ZX, Chen XD, Ni LN, Shen P. [Horizontal gene transfer]. Yi Chuan. 2003 Sep; 25(5):623-7. PMID: 15639945.
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    57. Kojima H, Kaita KD, Xu Z, Ou JH, Gong Y, Zhang M, Minuk GY. The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice. J Hepatol. 2003 Aug; 39(2):262-8. PMID: 12873824.
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    58. Zheng Y, Li J, Johnson DL, Ou JH. Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway. J Virol. 2003 Jul; 77(14):7707-12. PMID: 12829809; PMCID: PMC161924.
    59. Choi J, Xu Z, Ou JH. Triple decoding of hepatitis C virus RNA by programmed translational frameshifting. Mol Cell Biol. 2003 Mar; 23(5):1489-97. PMID: 12588970; PMCID: PMC151691.
    60. Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C. Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4. J Biol Chem. 2003 Mar 14; 278(11):9353-60. PMID: 12522137.
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    61. Xu Z, Choi J, Lu W, Ou JH. Hepatitis C virus f protein is a short-lived protein associated with the endoplasmic reticulum. J Virol. 2003 Jan; 77(2):1578-83. PMID: 12502871; PMCID: PMC140853.
    62. Lu W, Ou JH. Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C. Virology. 2002 Aug 15; 300(1):20-30. PMID: 12202202.
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    63. Yamaga AK, Ou JH. Membrane topology of the hepatitis C virus NS2 protein. J Biol Chem. 2002 Sep 06; 277(36):33228-34. PMID: 12082096.
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    64. Li J, Xu Z, Zheng Y, Johnson DL, Ou JH. Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins. J Virol. 2002 Jun; 76(12):5875-81. PMID: 12021320; PMCID: PMC136206.
    65. Xu Z, Yen TS, Wu L, Madden CR, Tan W, Slagle BL, Ou JH. Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J Virol. 2002 Mar; 76(5):2579-84. PMID: 11836439; PMCID: PMC153824.
    66. Lu W, Strohecker A, Ou Jh JH. Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase. J Biol Chem. 2001 Dec 21; 276(51):47993-9. PMID: 11606596.
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    67. Li J, Ou JH. Differential regulation of hepatitis B virus gene expression by the Sp1 transcription factor. J Virol. 2001 Sep; 75(18):8400-6. PMID: 11507185; PMCID: PMC115085.
    68. Ou JH, Pan CC, Lin JS, Tzai TS, Yang WH, Chang CC, Cheng HL, Lin YM, Tong YC. Transitional cell carcinoma in dialysis patients. Eur Urol. 2000 Jan; 37(1):90-4. PMID: 10671792.
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    69. Lu W, Lo SY, Chen M, Wu Kj, Fung YK, Ou JH. Activation of p53 tumor suppressor by hepatitis C virus core protein. Virology. 1999 Nov 10; 264(1):134-41. PMID: 10544138.
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    70. Li J, Buckwold VE, Hon MW, Ou JH. Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation. J Virol. 1999 Feb; 73(2):1239-44. PMID: 9882327; PMCID: PMC103946.
    71. Lo SY, Ou JH. Expression and Dimerization of Hepatitis C Virus Core Protein in E. coli. Methods Mol Med. 1999; 19:325-30. PMID: 21374373.
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    72. Ou JH. Molecular biology of hepatitis B virus e antigen. J Gastroenterol Hepatol. 1997 Oct; 12(9-10):S178-87. PMID: 9407336.
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    73. Buckwold VE, Xu Z, Yen TS, Ou JH. Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication. J Gen Virol. 1997 Aug; 78 ( Pt 8):2055-65. PMID: 9267007.
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    74. Matsumoto M, Hsieh TY, Zhu N, VanArsdale T, Hwang SB, Jeng KS, Gorbalenya AE, Lo SY, Ou JH, Ware CF, Lai MM. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol. 1997 Feb; 71(2):1301-9. PMID: 8995654; PMCID: PMC191185.
    75. Buckwold VE, Chen M, Ou JH. Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter. Virology. 1997 Jan 20; 227(2):515-8. PMID: 9018153.
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    76. Buckwold VE, Xu Z, Chen M, Yen TS, Ou JH. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol. 1996 Sep; 70(9):5845-51. PMID: 8709203; PMCID: PMC190601.
    77. Lo SY, Selby MJ, Ou JH. Interaction between hepatitis C virus core protein and E1 envelope protein. J Virol. 1996 Aug; 70(8):5177-82. PMID: 8764026; PMCID: PMC190473.
    78. Yeh CT, Hong LH, Ou JH, Chu CM, Liaw YF. Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22. Arch Virol. 1996; 141(3-4):425-38. PMID: 8645085.
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    79. Chen M, Ou JH. Cell type-dependent regulation of the activity of the negative regulatory element of the hepatitis B virus core promoter. Virology. 1995 Dec 01; 214(1):198-206. PMID: 8525615.
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    80. Lo SY, Masiarz F, Hwang SB, Lai MM, Ou JH. Differential subcellular localization of hepatitis C virus core gene products. Virology. 1995 Nov 10; 213(2):455-61. PMID: 7491770.
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    81. Hwang SB, Lo SY, Ou JH, Lai MM. Detection of Cellular Proteins and Viral Core Protein Interacting with the 5' Untranslated Region of Hepatitis C Virus RNA. J Biomed Sci. 1995 Aug; 2(3):227-236. PMID: 11725058.
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    82. Lu CC, Chen M, Ou JH, Yen TS. Key role of a CCAAT element in regulating hepatitis B virus surface protein expression. Virology. 1995 Feb 01; 206(2):1155-8. PMID: 7856091.
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    83. Liao W, Ou JH. Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs. J Virol. 1995 Feb; 69(2):1025-9. PMID: 7815479; PMCID: PMC188672.
    84. Chen M, Hieng S, Qian X, Costa R, Ou JH. Regulation of hepatitis B virus ENI enhancer activity by hepatocyte-enriched transcription factor HNF3. Virology. 1994 Nov 15; 205(1):127-32. PMID: 7975208.
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    85. Yeh CT, Ou JH, Chu CM, Liaw YF. Alteration of the subcellular localization of hepatitis B virus core protein by large but not small surface proteins. Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1348-54. PMID: 8093050.
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    86. Yeh CT, Han CM, Lo SY, Ou JH, Fan KD, Sheen IS, Chu CM, Liaw YF. Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment. J Clin Microbiol. 1994 Sep; 32(9):2235-41. PMID: 7529251; PMCID: PMC263974.
    87. Lo SY, Selby M, Tong M, Ou JH. Comparative studies of the core gene products of two different hepatitis C virus isolates: two alternative forms determined by a single amino acid substitution. Virology. 1994 Feb 15; 199(1):124-31. PMID: 8116235.
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    88. Yeh CT, Wong SW, Fung YK, Ou JH. Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6459-63. PMID: 8341655; PMCID: PMC46951.
    89. Guo W, Chen M, Yen TS, Ou JH. Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation. Mol Cell Biol. 1993 Jan; 13(1):443-8. PMID: 8417343; PMCID: PMC358924.
    90. Liu ES, Ou JH, Lee AS. Brefeldin A as a regulator of grp78 gene expression in mammalian cells. J Biol Chem. 1992 Apr 05; 267(10):7128-33. PMID: 1551919.
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    91. Xia YP, Yeh CT, Ou JH, Lai MM. Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex. J Virol. 1992 Feb; 66(2):914-21. PMID: 1731113; PMCID: PMC240792.
    92. Guo WT, Bell KD, Ou JH. Characterization of the hepatitis B virus EnhI enhancer and X promoter complex. J Virol. 1991 Dec; 65(12):6686-92. PMID: 1658368; PMCID: PMC250743.
    93. Wang J, Lee AS, Ou JH. Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment. J Virol. 1991 Sep; 65(9):5080-3. PMID: 1870212; PMCID: PMC248973.
    94. Yeh CT, Ou JH. Phosphorylation of hepatitis B virus precore and core proteins. J Virol. 1991 May; 65(5):2327-31. PMID: 1850014; PMCID: PMC240583.
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