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Jing-Hsiung James Ou, PhD

Title(s)Business Title Interim Chair and Professor of Molecular Microbiology & Immunology, Fletcher Jones Foundation Chair in Molecular Microbiology and Immunology
AddressHMR 402A 2011 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 1720
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    Collapse Biography 
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    National Taiwan University, TaiwanB.S.06/1976Zoology
    California Institute of Technology, Pasadena, CaliforniaPh.D.06/1982Molecular Virology

    Collapse Overview 
    Collapse Overview
    The research of our laboratory is centered on hepatitis B virus (HBV), hepatitis C virus (HCV), and liver cancer. We are particularly interested in understanding how these two viruses interact with their host cells, how they invaded host immunity to establish persistent infection, and how they cause liver diseases including hepatocellular carcinoma.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Partial Hepatectomy and Castration of HBV Transgenic Mice. Methods Mol Biol. 2017; 1540:259-266. Tian Y, Ou JJ. PMID: 27975324.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6. J Virol. 2016 Dec 01; 90(23):10928-10935. Chan ST, Lee J, Narula M, Ou JJ. PMID: 27681126.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    3. Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016 05 17; 44(5):1204-14. Tian Y, Kuo CF, Akbari O, Ou JH. PMID: 27156385.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    4. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. PMID: 26799652.
      View in: PubMed   Mentions: 1506     Fields:    Translation:HumansAnimals
    5. Hepatitis C virus and autophagy. Biol Chem. 2015 Nov; 396(11):1215-22. Wang L, Ou JH. PMID: 26024249.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    6. TNF-a Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism. PLoS Pathog. 2015 May; 11(5):e1004937. Lee J, Tian Y, Chan ST, Kim JY, Cho C, Ou JH. PMID: 26023919.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    7. Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma. Virol Sin. 2015 Apr; 30(2):85-91. Tian Y, Ou JH. PMID: 25862579.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. Oncogenic viruses and cancer. Virol Sin. 2015 Apr; 30(2):83-4. Luo GG, Ou JH. PMID: 25924992.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    9. HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. PLoS Pathog. 2015 Mar; 11(3):e1004764. Wang L, Tian Y, Ou JH. PMID: 25807108.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    10. Technical standards for hepatitis B virus X protein (HBx) research. Hepatology. 2015 Apr; 61(4):1416-24. Slagle BL, Andrisani OM, Bouchard MJ, Lee CG, Ou JH, Siddiqui A. PMID: 25099228.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    11. Autophagy, a double-edged sword in hepatocarcinogenesis. Mol Cell Oncol. 2015 Oct-Dec; 2(4):e1004968. Tian Y, Wang L, Ou JH. PMID: 27308502.
      View in: PubMed   Mentions:
    12. Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis. Cell Death Differ. 2015 Jun; 22(6):1025-34. Tian Y, Kuo CF, Sir D, Wang L, Govindarajan S, Petrovic LM, Ou JH. PMID: 25526090.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    13. Virus control goes epigenetic. PLoS Pathog. 2014 Sep; 10(9):e1004370. Ou JH. PMID: 25211140.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Functions of autophagy in normal and diseased liver. Autophagy. 2013 Aug; 9(8):1131-58. Czaja MJ, Ding WX, Donohue TM, Friedman SL, Kim JS, Komatsu M, Lemasters JJ, Lemoine A, Lin JD, Ou JH, Perlmutter DH, Randall G, Ray RB, Tsung A, Yin XM. PMID: 23774882.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimals
    15. Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry. J Biol Chem. 2012 Dec 07; 287(50):41922-30. Liu Z, Tian Y, Machida K, Lai MM, Luo G, Foung SK, Ou JH. PMID: 23095753.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    16. Hepatitis C virus translation preferentially depends on active RNA replication. PLoS One. 2012; 7(8):e43600. Liu HM, Aizaki H, Machida K, Ou JH, Lai MM. PMID: 22937067.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Viral-load-dependent effects of liver injury and regeneration on hepatitis B virus replication in mice. J Virol. 2012 Sep; 86(18):9599-605. Tian Y, Chen WL, Kuo CF, Ou JH. PMID: 22718822.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    18. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One. 2012; 7(5):e36818. Wang Q, Na B, Ou JH, Pulliam L, Yen TS. PMID: 22606292.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells. Mol Biotechnol. 2012 May; 51(1):1-8. Mo RH, Zaro JL, Ou JH, Shen WC. PMID: 21660602.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Replication of hepatitis C virus RNA on autophagosomal membranes. J Biol Chem. 2012 May 25; 287(22):18036-43. Sir D, Kuo CF, Tian Y, Liu HM, Huang EJ, Jung JU, Machida K, Ou JH. PMID: 22496373.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    21. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. PMID: 22966490.
      View in: PubMed   Mentions: 1502     Fields:    Translation:HumansAnimals
    22. Enhancement of hepatitis B virus replication by androgen and its receptor in mice. J Virol. 2012 Feb; 86(4):1904-10. Tian Y, Kuo CF, Chen WL, Ou JH. PMID: 22156518.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. IFN-a/ß and autophagy: tug-of-war between HCV and the host. Autophagy. 2011 Nov; 7(11):1394-6. Sun J, Desai MM, Soong L, Ou JH. PMID: 21997372.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    24. Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury. PLoS One. 2011; 6(10):e26240. Na B, Huang Z, Wang Q, Qi Z, Tian Y, Lu CC, Yu J, Hanes MA, Kakar S, Huang EJ, Ou JH, Liu L, Yen TS. PMID: 22022578.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. Autophagy required for hepatitis B virus replication in transgenic mice. J Virol. 2011 Dec; 85(24):13453-6. Tian Y, Sir D, Kuo CF, Ann DK, Ou JH. PMID: 21957292.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    26. Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. J Virol. 2011 Oct; 85(20):10899-904. Inn KS, Lee SH, Rathbun JY, Wong LY, Toth Z, Machida K, Ou JH, Jung JU. PMID: 21835791.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    27. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PLoS One. 2011; 6(7):e22979. Kido T, Ou JH, Lau YF. PMID: 21829568.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. Effects of interferon-a/ß on HBV replication determined by viral load. PLoS Pathog. 2011 Jul; 7(7):e1002159. Tian Y, Chen WL, Ou JH. PMID: 21829354.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    29. Krüppel-like factor 15 activates hepatitis B virus gene expression and replication. Hepatology. 2011 Jul; 54(1):109-21. Zhou J, Tan T, Tian Y, Zheng B, Ou JH, Huang EJ, Yen TS. PMID: 21503941.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    30. Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 2010 Dec 01; 185(11):6985-98. Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. PMID: 20974981.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    31. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2010 Aug; 52(2):480-92. Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. PMID: 20683948.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    32. Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo. J Virol. 2010 Sep; 84(18):9326-31. Zhang Z, Sun E, Ou JH, Liang TJ. PMID: 20592087.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med. 2010 May 19; 2(32):32ra35. Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, Ryan CK, Hung YC, Yeh S, Chang C. PMID: 20484730.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    34. Autophagy by hepatitis B virus and for hepatitis B virus. Autophagy. 2010 May; 6(4):548-9. Sir D, Ann DK, Ou JH. PMID: 20305390.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    35. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4383-8. Sir D, Tian Y, Chen WL, Ann DK, Yen TS, Ou JH. PMID: 20142477.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    36. Autophagy in viral replication and pathogenesis. Mol Cells. 2010 Jan; 29(1):1-7. Sir D, Ou JH. PMID: 20077024.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    37. PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis. Autophagy. 2009 Feb; 5(2):244-6. Chen JL, Lin HH, Kim KJ, Lin A, Ou JH, Ann DK. PMID: 19098423.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    38. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. PMID: 19171902.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    39. Ubiquitin-independent degradation of hepatitis C virus F protein. J Virol. 2009 Jan; 83(2):612-21. Yuksek K, Chen WL, Chien D, Ou JH. PMID: 18971267.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    40. Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology. 2008 Oct; 48(4):1054-61. Sir D, Chen WL, Choi J, Wakita T, Yen TS, Ou JH. PMID: 18688877.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansCells
    41. Perturbation of autophagic pathway by hepatitis C virus. Autophagy. 2008 Aug; 4(6):830-1. Sir D, Liang C, Chen WL, Jung JU, Ou JH. PMID: 18635950.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    42. Beyond autophagy: the role of UVRAG in membrane trafficking. Autophagy. 2008 Aug; 4(6):817-20. Liang C, Sir D, Lee S, Ou JH, Jung JU. PMID: 18612260.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    43. Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc. J Biomed Sci. 2008 Jul; 15(4):417-25. Ma HC, Lin TW, Li H, Iguchi-Ariga SM, Ariga H, Chuang YL, Ou JH, Lo SY. PMID: 18398700.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    44. Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein. Virology. 2007 Jul 05; 363(2):454-61. Zheng Y, Chen WL, Ma WL, Chang C, Ou JH. PMID: 17335866.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    45. Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology. 2007 Jan; 45(1):16-21. Zheng Y, Chen WL, Louie SG, Yen TS, Ou JH. PMID: 17187428.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    46. Redox modulation of the hepatitis C virus replication complex is calcium dependent. Free Radic Biol Med. 2006 Nov 01; 41(9):1488-98. Choi J, Forman HJ, Ou JH, Lai MM, Seronello S, Nandipati A. PMID: 17023276.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    47. [Genetics of heteroplasmy in the mtDNA control region among the Chinese Han population]. Fa Yi Xue Za Zhi. 2006 Jun; 22(3):198-203. Jiang QC, Tong DY, Sun HY, Ou JH, Chen LX, Wu XY. PMID: 16856343.
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    48. Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G847-51. Choi J, Ou JH. PMID: 16603728.
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    49. Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein. Virology. 2005 Nov 10; 342(1):150-8. Zheng Y, Fu XD, Ou JH. PMID: 16122776.
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    50. Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein. J Virol. 2004 Jul; 78(13):6908-14. Zheng Y, Li J, Ou JH. PMID: 15194767.
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    51. The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo. J Virol. 2004 Apr; 78(7):3797-802. Lee KJ, Choi J, Ou JH, Lai MM. PMID: 15016899.
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    52. Endogenous polymerase assay for the analysis of hepatitis B virus in transgenic mice. Methods Mol Med. 2004; 95:295-302. Xu Z, Ou JH. PMID: 14762312.
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    53. A heat inducible tyrosinase with distinct properties from Bacillus thuringiensis. Lett Appl Microbiol. 2004; 39(5):407-12. Liu N, Zhang T, Wang YJ, Huang YP, Ou JH, Shen P. PMID: 15482430.
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    54. Phosphorylation analysis of hepatitis B virus core protein in mammalian cells. Methods Mol Med. 2004; 95:227-33. Li J, Zheng Y, Choi J, Ou JH. PMID: 14762306.
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    55. Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells. Hepatology. 2004 Jan; 39(1):81-9. Choi J, Lee KJ, Zheng Y, Yamaga AK, Lai MM, Ou JH. PMID: 14752826.
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    56. [Horizontal gene transfer]. Yi Chuan. 2003 Sep; 25(5):623-7. Ou JH, Xie ZX, Chen XD, Ni LN, Shen P. PMID: 15639945.
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    57. The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice. J Hepatol. 2003 Aug; 39(2):262-8. Kojima H, Kaita KD, Xu Z, Ou JH, Gong Y, Zhang M, Minuk GY. PMID: 12873824.
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    58. Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway. J Virol. 2003 Jul; 77(14):7707-12. Zheng Y, Li J, Johnson DL, Ou JH. PMID: 12829809.
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    59. Triple decoding of hepatitis C virus RNA by programmed translational frameshifting. Mol Cell Biol. 2003 Mar; 23(5):1489-97. Choi J, Xu Z, Ou JH. PMID: 12588970.
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    60. Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4. J Biol Chem. 2003 Mar 14; 278(11):9353-60. Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C. PMID: 12522137.
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    61. Hepatitis C virus f protein is a short-lived protein associated with the endoplasmic reticulum. J Virol. 2003 Jan; 77(2):1578-83. Xu Z, Choi J, Lu W, Ou JH. PMID: 12502871.
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    62. Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C. Virology. 2002 Aug 15; 300(1):20-30. Lu W, Ou JH. PMID: 12202202.
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    63. Membrane topology of the hepatitis C virus NS2 protein. J Biol Chem. 2002 Sep 06; 277(36):33228-34. Yamaga AK, Ou JH. PMID: 12082096.
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    64. Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins. J Virol. 2002 Jun; 76(12):5875-81. Li J, Xu Z, Zheng Y, Johnson DL, Ou JH. PMID: 12021320.
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    65. Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J Virol. 2002 Mar; 76(5):2579-84. Xu Z, Yen TS, Wu L, Madden CR, Tan W, Slagle BL, Ou JH. PMID: 11836439.
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    66. Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase. J Biol Chem. 2001 Dec 21; 276(51):47993-9. Lu W, Strohecker A, Ou Jh JH. PMID: 11606596.
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    67. Differential regulation of hepatitis B virus gene expression by the Sp1 transcription factor. J Virol. 2001 Sep; 75(18):8400-6. Li J, Ou JH. PMID: 11507185.
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    68. Transitional cell carcinoma in dialysis patients. Eur Urol. 2000 Jan; 37(1):90-4. Ou JH, Pan CC, Lin JS, Tzai TS, Yang WH, Chang CC, Cheng HL, Lin YM, Tong YC. PMID: 10671792.
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    69. Activation of p53 tumor suppressor by hepatitis C virus core protein. Virology. 1999 Nov 10; 264(1):134-41. Lu W, Lo SY, Chen M, Wu Kj, Fung YK, Ou JH. PMID: 10544138.
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    70. Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation. J Virol. 1999 Feb; 73(2):1239-44. Li J, Buckwold VE, Hon MW, Ou JH. PMID: 9882327.
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    71. Expression and Dimerization of Hepatitis C Virus Core Protein in E. coli. Methods Mol Med. 1999; 19:325-30. Lo SY, Ou JH. PMID: 21374373.
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    72. Molecular biology of hepatitis B virus e antigen. J Gastroenterol Hepatol. 1997 Oct; 12(9-10):S178-87. Ou JH. PMID: 9407336.
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    73. Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication. J Gen Virol. 1997 Aug; 78 ( Pt 8):2055-65. Buckwold VE, Xu Z, Yen TS, Ou JH. PMID: 9267007.
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    74. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol. 1997 Feb; 71(2):1301-9. Matsumoto M, Hsieh TY, Zhu N, VanArsdale T, Hwang SB, Jeng KS, Gorbalenya AE, Lo SY, Ou JH, Ware CF, Lai MM. PMID: 8995654.
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    75. Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter. Virology. 1997 Jan 20; 227(2):515-8. Buckwold VE, Chen M, Ou JH. PMID: 9018153.
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    76. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol. 1996 Sep; 70(9):5845-51. Buckwold VE, Xu Z, Chen M, Yen TS, Ou JH. PMID: 8709203.
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    77. Interaction between hepatitis C virus core protein and E1 envelope protein. J Virol. 1996 Aug; 70(8):5177-82. Lo SY, Selby MJ, Ou JH. PMID: 8764026.
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    78. Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22. Arch Virol. 1996; 141(3-4):425-38. Yeh CT, Hong LH, Ou JH, Chu CM, Liaw YF. PMID: 8645085.
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    79. Cell type-dependent regulation of the activity of the negative regulatory element of the hepatitis B virus core promoter. Virology. 1995 Dec 01; 214(1):198-206. Chen M, Ou JH. PMID: 8525615.
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    80. Differential subcellular localization of hepatitis C virus core gene products. Virology. 1995 Nov 10; 213(2):455-61. Lo SY, Masiarz F, Hwang SB, Lai MM, Ou JH. PMID: 7491770.
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    81. Detection of Cellular Proteins and Viral Core Protein Interacting with the 5' Untranslated Region of Hepatitis C Virus RNA. J Biomed Sci. 1995 Aug; 2(3):227-236. Hwang SB, Lo SY, Ou JH, Lai MM. PMID: 11725058.
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    82. Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs. J Virol. 1995 Feb; 69(2):1025-9. Liao W, Ou JH. PMID: 7815479.
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    83. Key role of a CCAAT element in regulating hepatitis B virus surface protein expression. Virology. 1995 Feb 01; 206(2):1155-8. Lu CC, Chen M, Ou JH, Yen TS. PMID: 7856091.
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    84. Regulation of hepatitis B virus ENI enhancer activity by hepatocyte-enriched transcription factor HNF3. Virology. 1994 Nov 15; 205(1):127-32. Chen M, Hieng S, Qian X, Costa R, Ou JH. PMID: 7975208.
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    85. Alteration of the subcellular localization of hepatitis B virus core protein by large but not small surface proteins. Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1348-54. Yeh CT, Ou JH, Chu CM, Liaw YF. PMID: 8093050.
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    86. Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment. J Clin Microbiol. 1994 Sep; 32(9):2235-41. Yeh CT, Han CM, Lo SY, Ou JH, Fan KD, Sheen IS, Chu CM, Liaw YF. PMID: 7529251.
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    87. Comparative studies of the core gene products of two different hepatitis C virus isolates: two alternative forms determined by a single amino acid substitution. Virology. 1994 Feb 15; 199(1):124-31. Lo SY, Selby M, Tong M, Ou JH. PMID: 8116235.
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    88. Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6459-63. Yeh CT, Wong SW, Fung YK, Ou JH. PMID: 8341655.
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    89. Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation. Mol Cell Biol. 1993 Jan; 13(1):443-8. Guo W, Chen M, Yen TS, Ou JH. PMID: 8417343.
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    90. Brefeldin A as a regulator of grp78 gene expression in mammalian cells. J Biol Chem. 1992 Apr 05; 267(10):7128-33. Liu ES, Ou JH, Lee AS. PMID: 1551919.
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    91. Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex. J Virol. 1992 Feb; 66(2):914-21. Xia YP, Yeh CT, Ou JH, Lai MM. PMID: 1731113.
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    92. Characterization of the hepatitis B virus EnhI enhancer and X promoter complex. J Virol. 1991 Dec; 65(12):6686-92. Guo WT, Bell KD, Ou JH. PMID: 1658368.
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    93. Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment. J Virol. 1991 Sep; 65(9):5080-3. Wang J, Lee AS, Ou JH. PMID: 1870212.
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    94. Phosphorylation of hepatitis B virus precore and core proteins. J Virol. 1991 May; 65(5):2327-31. Yeh CT, Ou JH. PMID: 1850014.
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