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Bangyan L Stiles, PhD

TitleProfessor
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressPSC 402C
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 2184
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    Collapse Research 
    Collapse Research Activities and Funding
    The role of PTEN and AKT2 in the malignant transformation of liver progenitor cel
    NIH/NCI R01CA154986Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    The mechanism of beta-cell regeneration
    NIH/NIDDK R01DK084241Aug 5, 2010 - Jun 30, 2015
    Role: Principal Investigator
    The Role of PTEN in B-cell regeneration through epithelial-mesenchymal transition
    NIH/NIDDK R21DK075928Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen CY, Chen J, He L, Stiles B. PTEN: Tumor Suppressor and Metabolic Regulator. Front Endocrinol (Lausanne). 2018; 9:338. PMID: 30038596.
      View in: PubMed
    2. Lee J, Liu K, Stiles B, Ou JJ. Mitophagy and hepatic cancer stem cells. Autophagy. 2018; 14(4):715-716. PMID: 29313421.
      View in: PubMed
    3. Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles B, Valasek M, Sander M. Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5. PMID: 29273451.
      View in: PubMed
    4. Jia C, Medina V, Liu C, He L, Qian D, Taojian T, Okamoto CT, Stiles B. Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development. Hepatol Commun. 2017 Apr; 1(2):153-167. PMID: 29152604.
      View in: PubMed
    5. He L, Gubbins J, Peng Z, Medina V, Fei F, Asahina K, Wang J, Kahn M, Rountree CB, Stiles B. Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair. 2016; 9:8. PMID: 27307790; PMCID: PMC4908727.
      View in: PubMed, PubMed Central
    6. Johnson DL, Stiles B. Maf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab. 2016 10; 27(10):742-750. PMID: 27296319; PMCID: PMC5035567 [Available on 10/01/17].
      View in: PubMed, PubMed Central
    7. Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles B, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152. PMID: 27124661; PMCID: PMC4849752.
      View in: PubMed, PubMed Central
    8. Bayan JA, Peng Z, Zeng N, He L, Chen J, Stiles B. Crosstalk Between Activated Myofibroblasts and ß Cells in Injured Mouse Pancreas. Pancreas. 2015 Oct; 44(7):1111-20. PMID: 26333110; PMCID: PMC4780408 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    9. Liu Z, Patil IY, Jiang T, Sancheti H, Walsh JP, Stiles B, Yin F, Cadenas E. High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity. PLoS One. 2015; 10(5):e0128274. PMID: 26023930.
      View in: PubMed
    10. Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles B, Johnson DL. Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789. PMID: 25502566; PMCID: PMC4263377.
      View in: PubMed, PubMed Central
    11. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul 01; 7(332):pe15. PMID: 24985344; PMCID: PMC4367864.
      View in: PubMed, PubMed Central
    12. Wu JB, Shao C, Li X, Li Q, Hu P, Shi C, Li Y, Chen YT, Yin F, Liao CP, Stiles B, Zhau HE, Shih JC, Chung LW. Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest. 2014 Jul; 124(7):2891-908. PMID: 24865426; PMCID: PMC4071401.
      View in: PubMed, PubMed Central
    13. Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles B, Ronis MJ, Petersen DR. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 2014; 9(5):e96553. PMID: 24818992; PMCID: PMC4018288.
      View in: PubMed, PubMed Central
    14. Chen WT, Tseng CC, Pfaffenbach K, Kanel G, Luo B, Stiles B, Lee AS. Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology. 2014 Mar; 59(3):947-57. PMID: 24027047; PMCID: PMC4214272.
      View in: PubMed, PubMed Central
    15. Yang KT, Bayan JA, Zeng N, Aggarwal R, He L, Peng Z, Kassa A, Kim M, Luo Z, Shi Z, Medina V, Boddupally K, Stiles B. Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice. Diabetologia. 2014 Feb; 57(2):352-61. PMID: 24162585.
      View in: PubMed
    16. Tsen F, Bhatia A, O'Brien K, Cheng CF, Chen M, Hay N, Stiles B, Woodley DT, Li W. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec; 33(24):4947-59. PMID: 24126057.
      View in: PubMed
    17. Zeng N, Yang KT, Bayan JA, He L, Aggarwal R, Stiles JW, Hou X, Medina V, Abad D, Palian BM, Al-Abdullah I, Kandeel F, Johnson DL, Stiles B. PTEN controls ß-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. Aging Cell. 2013 Dec; 12(6):1000-11. PMID: 23826727; PMCID: PMC3838454.
      View in: PubMed, PubMed Central
    18. Li Y, He L, Zeng N, Sahu D, Cadenas E, Shearn C, Li W, Stiles B. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor a (ERRa). J Biol Chem. 2013 Aug 30; 288(35):25007-24. PMID: 23836899; PMCID: PMC3757167.
      View in: PubMed, PubMed Central
    19. Li C, Li Y, He L, Agarwal AR, Zeng N, Cadenas E, Stiles B. PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med. 2013 Jul; 60:29-40. PMID: 23376468; PMCID: PMC3654039.
      View in: PubMed, PubMed Central
    20. Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, Lin LI, Ann DK. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy. 2012 Oct; 8(10):1477-93. PMID: 22906967; PMCID: PMC3679231.
      View in: PubMed, PubMed Central
    21. Moon BC, Hernandez-Ono A, Stiles B, Wu H, Ginsberg HN. Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):236-46. PMID: 22155452; PMCID: PMC3870321.
      View in: PubMed, PubMed Central
    22. Zeng N, Li Y, He L, Xu X, Galicia V, Deng C, Stiles B. Adaptive basal phosphorylation of eIF2a is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Mol Cancer Res. 2011 Dec; 9(12):1708-17. PMID: 22009178; PMCID: PMC4351767.
      View in: PubMed, PubMed Central
    23. Ko KS, Tomasi ML, Iglesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles B, Li TW, Yang H, Martínez-Chantar ML, Mato JM, Lu SC. Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology. 2010 Dec; 52(6):2096-108. PMID: 20890892; PMCID: PMC3005187.
      View in: PubMed, PubMed Central
    24. Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles B. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82. PMID: 20837017; PMCID: PMC2997180.
      View in: PubMed, PubMed Central
    25. Ding W, You H, Dang H, LeBlanc F, Galicia V, Lu SC, Stiles B, Rountree CB. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology. 2010 Sep; 52(3):945-53. PMID: 20564331; PMCID: PMC3032356.
      View in: PubMed, PubMed Central
    26. He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles B. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol. 2010 May; 176(5):2302-8. PMID: 20348245; PMCID: PMC2861095.
      View in: PubMed, PubMed Central
    27. Zeng N, Bayan JA, He L, Stiles B. The Role of PTEN in ß-Cell Growth. Open Endocrinol J. 2010; 4:23-32. PMID: 23853672.
      View in: PubMed
    28. Stiles B. PI-3-K and AKT: Onto the mitochondria. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1276-82. PMID: 19720099.
      View in: PubMed
    29. Rountree CB, Ding W, He L, Stiles B. Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells. 2009 Feb; 27(2):290-9. PMID: 19008348; PMCID: PMC2847372.
      View in: PubMed, PubMed Central
    30. Stiles B. Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles. Int J Biochem Cell Biol. 2009 Apr; 41(4):757-61. PMID: 18950730; PMCID: PMC2940266.
      View in: PubMed, PubMed Central
    31. Valamehr B, Jonas SJ, Polleux J, Qiao R, Guo S, Gschweng EH, Stiles B, Kam K, Luo TJ, Witte ON, Liu X, Dunn B, Wu H. Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14459-64. PMID: 18791068; PMCID: PMC2567159.
      View in: PubMed, PubMed Central
    32. Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006 Jul; 116(7):1843-52. PMID: 16767220; PMCID: PMC1474816.
      View in: PubMed, PubMed Central
    33. Stiles B, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006 Apr; 26(7):2772-81. PMID: 16537919; PMCID: PMC1430339.
      View in: PubMed, PubMed Central
    34. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95. PMID: 16169464.
      View in: PubMed
    35. Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005 Mar; 25(6):2498-510. PMID: 15743841; PMCID: PMC1061603.
      View in: PubMed, PubMed Central
    36. Stiles B, Groszer M, Wang S, Jiao J, Wu H. PTENless means more. Dev Biol. 2004 Sep 15; 273(2):175-84. PMID: 15328005.
      View in: PubMed
    37. Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2082-7. PMID: 14769918; PMCID: PMC357055.
      View in: PubMed, PubMed Central
    38. Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol. 2002 Jun; 22(11):3842-51. PMID: 11997518; PMCID: PMC133830.
      View in: PubMed, PubMed Central
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