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Bangyan L Stiles, PhD

Title(s)Professor
AddressPSC 402C
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 2184
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    Collapse Research 
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    Robust Inference in the Presence of Data Heterogeneity and Structured Missing Data
    NIH R01LM013315Sep 1, 2019 - Aug 31, 2022
    Role: Co-Principal Investigator
    The role of PTEN and AKT2 in the malignant transformation of liver progenitor cel
    NIH R01CA154986Apr 1, 2013 - Mar 31, 2020
    Role: Principal Investigator
    The mechanism of beta-cell regeneration
    NIH R01DK084241Aug 5, 2010 - Jun 30, 2017
    Role: Principal Investigator
    The Role of PTEN in B-cell regeneration through epithelial-mesenchymal transition
    NIH R21DK075928Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins. ACS Chem Biol. 2021 Feb 01. Lam AT, Zhang XN, Courouble VV, Strutzenberg TS, Pei H, Stiles BL, Louie SG, Griffin PR, Zhang Y. PMID: 33524253.
      View in: PubMed   Mentions:    Fields:    
    2. AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic ß Cells. Mol Cell Biol. 2020 05 14; 40(11). Peng Z, Aggarwal R, Zeng N, He L, Stiles EX, Debebe A, Chen J, Chen CY, Stiles BL. PMID: 32179553.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2. Biochem J. 2020 03 13; 477(5):1021-1031. He L, Li Y, Zeng N, Stiles BL. PMID: 32096546.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions. Cold Spring Harb Perspect Med. 2020 01 02; 10(1). Tu T, Chen J, Chen L, Stiles BL. PMID: 31548229.
      View in: PubMed   Mentions:    Fields:    
    5. Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. Biochemistry. 2020 Sep 01; 59(34):3169-3179. Walter LA, Lin YH, Halbrook CJ, Chuh KN, He L, Pedowitz NJ, Batt AR, Brennan CK, Stiles BL, Lyssiotis CA, Pratt MR. PMID: 31625393.
      View in: PubMed   Mentions: 1     Fields:    
    6. Extracellular vesicle microRNA quantification from plasma using an integrated microfluidic device. Commun Biol. 2019; 2:189. Ramshani Z, Zhang C, Richards K, Chen L, Xu G, Stiles BL, Hill R, Senapati S, Go DB, Chang HC. PMID: 31123713.
      View in: PubMed   Mentions:
    7. Brain metabolic and functional alterations in a liver-specific PTEN knockout mouse model. PLoS One. 2018; 13(9):e0204043. Patil I, Sancheti H, Stiles BL, Cadenas E. PMID: 30235271.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. PTEN: Tumor Suppressor and Metabolic Regulator. Front Endocrinol (Lausanne). 2018; 9:338. Chen CY, Chen J, He L, Stiles BL. PMID: 30038596.
      View in: PubMed   Mentions:
    9. Mitophagy and hepatic cancer stem cells. Autophagy. 2018; 14(4):715-716. Lee J, Liu K, Stiles B, Ou JJ. PMID: 29313421.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5. Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles BL, Valasek M, Sander M. PMID: 29273451.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Wnt/ß-catenin activation and macrophage induction during liver cancer development following steatosis. Oncogene. 2017 10 26; 36(43):6020-6029. Debebe A, Medina V, Chen CY, Mahajan IM, Jia C, Fu D, He L, Zeng N, Stiles BW, Chen CL, Wang M, Aggarwal KR, Peng Z, Huang J, Chen J, Li M, Dong T, Atkins S, Borok Z, Yuan W, Machida K, Ju C, Kahn M, Johnson D, Stiles BL. PMID: 28671671.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development. Hepatol Commun. 2017 Apr; 1(2):153-167. Jia C, Medina V, Liu C, He L, Qian D, Taojian T, Okamoto CT, Stiles BL. PMID: 29152604.
      View in: PubMed   Mentions:
    13. Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair. 2016; 9:8. He L, Gubbins J, Peng Z, Medina V, Fei F, Asahina K, Wang J, Kahn M, Rountree CB, Stiles BL. PMID: 27307790.
      View in: PubMed   Mentions:
    14. Maf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab. 2016 10; 27(10):742-750. Johnson DL, Stiles BL. PMID: 27296319.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    15. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152. Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. PMID: 27124661.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Crosstalk Between Activated Myofibroblasts and ß Cells in Injured Mouse Pancreas. Pancreas. 2015 Oct; 44(7):1111-20. Bayan JA, Peng Z, Zeng N, He L, Chen J, Stiles BL. PMID: 26333110.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity. PLoS One. 2015; 10(5):e0128274. Liu Z, Patil IY, Jiang T, Sancheti H, Walsh JP, Stiles BL, Yin F, Cadenas E. PMID: 26023930.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    18. Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789. Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles BL, Johnson DL. PMID: 25502566.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul 01; 7(332):pe15. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. PMID: 24985344.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    20. Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest. 2014 Jul; 124(7):2891-908. Wu JB, Shao C, Li X, Li Q, Hu P, Shi C, Li Y, Chen YT, Yin F, Liao CP, Stiles BL, Zhau HE, Shih JC, Chung LW. PMID: 24865426.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    21. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 2014; 9(5):e96553. Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles BL, Ronis MJ, Petersen DR. PMID: 24818992.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    22. Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology. 2014 Mar; 59(3):947-57. Chen WT, Tseng CC, Pfaffenbach K, Kanel G, Luo B, Stiles BL, Lee AS. PMID: 24027047.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    23. Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice. Diabetologia. 2014 Feb; 57(2):352-61. Yang KT, Bayan JA, Zeng N, Aggarwal R, He L, Peng Z, Kassa A, Kim M, Luo Z, Shi Z, Medina V, Boddupally K, Stiles BL. PMID: 24162585.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. Oncogene. 2014 Oct 16; 33(42):4997-5005. Chen WT, Zhu G, Pfaffenbach K, Kanel G, Stiles B, Lee AS. PMID: 24141775.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    25. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec; 33(24):4947-59. Tsen F, Bhatia A, O'Brien K, Cheng CF, Chen M, Hay N, Stiles B, Woodley DT, Li W. PMID: 24126057.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. PTEN controls ß-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. Aging Cell. 2013 Dec; 12(6):1000-11. Zeng N, Yang KT, Bayan JA, He L, Aggarwal R, Stiles JW, Hou X, Medina V, Abad D, Palian BM, Al-Abdullah I, Kandeel F, Johnson DL, Stiles BL. PMID: 23826727.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    27. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor a (ERRa). J Biol Chem. 2013 Aug 30; 288(35):25007-24. Li Y, He L, Zeng N, Sahu D, Cadenas E, Shearn C, Li W, Stiles BL. PMID: 23836899.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    28. PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med. 2013 Jul; 60:29-40. Li C, Li Y, He L, Agarwal AR, Zeng N, Cadenas E, Stiles BL. PMID: 23376468.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    29. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy. 2012 Oct; 8(10):1477-93. Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, Lin LI, Ann DK. PMID: 22906967.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    30. miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma. Oncogenesis. 2012 Jun 11; 1:e15. Ding W, Dang H, You H, Steinway S, Takahashi Y, Wang HG, Liao J, Stiles B, Albert R, Rountree CB. PMID: 23552699.
      View in: PubMed   Mentions:
    31. Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):236-46. Moon BC, Hernandez-Ono A, Stiles B, Wu H, Ginsberg HN. PMID: 22155452.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Adaptive basal phosphorylation of eIF2a is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Mol Cancer Res. 2011 Dec; 9(12):1708-17. Zeng N, Li Y, He L, Xu X, Galicia V, Deng C, Stiles BL. PMID: 22009178.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    33. Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology. 2010 Dec; 52(6):2096-108. Ko KS, Tomasi ML, Iglesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles BL, Li TW, Yang H, Martínez-Chantar ML, Mato JM, Lu SC. PMID: 20890892.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    34. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82. Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL. PMID: 20837017.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    35. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology. 2010 Sep; 52(3):945-53. Ding W, You H, Dang H, LeBlanc F, Galicia V, Lu SC, Stiles B, Rountree CB. PMID: 20564331.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    36. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol. 2010 May; 176(5):2302-8. He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles BL. PMID: 20348245.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    37. The Role of PTEN in ß-Cell Growth. Open Endocrinol J. 2010; 4:23-32. Zeng N, Bayan JA, He L, Stiles B. PMID: 23853672.
      View in: PubMed   Mentions:
    38. PI-3-K and AKT: Onto the mitochondria. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1276-82. Stiles BL. PMID: 19720099.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    39. Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells. 2009 Feb; 27(2):290-9. Rountree CB, Ding W, He L, Stiles B. PMID: 19008348.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    40. Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles. Int J Biochem Cell Biol. 2009 Apr; 41(4):757-61. Stiles BL. PMID: 18950730.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    41. Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14459-64. Valamehr B, Jonas SJ, Polleux J, Qiao R, Guo S, Gschweng EH, Stiles B, Kam K, Luo TJ, Witte ON, Liu X, Dunn B, Wu H. PMID: 18791068.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    42. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006 Jul; 116(7):1843-52. Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX. PMID: 16767220.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    43. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006 Apr; 26(7):2772-81. Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. PMID: 16537919.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    44. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. PMID: 16169464.
      View in: PubMed   Mentions: 130     Fields:    Translation:Animals
    45. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005 Mar; 25(6):2498-510. Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H. PMID: 15743841.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    46. PTENless means more. Dev Biol. 2004 Sep 15; 273(2):175-84. Stiles B, Groszer M, Wang S, Jiao J, Wu H. PMID: 15328005.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    47. MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004 Apr; 11(7):609-18. Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS. PMID: 14724687.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    48. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2082-7. Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H. PMID: 14769918.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    49. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol. 2002 Jun; 22(11):3842-51. Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H. PMID: 11997518.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    50. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10314-9. Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL. PMID: 11504908.
      View in: PubMed   Mentions: 269     Fields:    Translation:HumansAnimalsCells
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