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Bangyan L Stiles, PhD

Title(s)Professor
Phone+1 323 442 2184
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    Robust Inference in the Presence of Data Heterogeneity and Structured Missing Data
    NIH/NLM R01LM013315Sep 1, 2019 - Aug 31, 2022
    Role: Co-Principal Investigator
    The role of PTEN and AKT2 in the malignant transformation of liver progenitor cel
    NIH/NCI R01CA154986Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    The mechanism of beta-cell regeneration
    NIH/NIDDK R01DK084241Aug 5, 2010 - Jun 30, 2015
    Role: Principal Investigator
    The Role of PTEN in B-cell regeneration through epithelial-mesenchymal transition
    NIH/NIDDK R21DK075928Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Walter LA, Lin YH, Halbrook CJ, Chuh KN, He L, Pedowitz NJ, Batt AR, Brennan CK, Stiles BL, Lyssiotis CA, Pratt MR. Inhibiting the hexosamine biosynthetic pathway lowers O-GlcNAcylation levels and sensitizes cancer to environmental stress. Biochemistry. 2019 Oct 18. PMID: 31625393.
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    2. Tu T, Chen J, Chen L, Stiles BL. Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions. Cold Spring Harb Perspect Med. 2019 Sep 23. PMID: 31548229.
      View in: PubMed
    3. Ramshani Z, Zhang C, Richards K, Chen L, Xu G, Stiles BL, Hill R, Senapati S, Go DB, Chang HC. Extracellular vesicle microRNA quantification from plasma using an integrated microfluidic device. Commun Biol. 2019; 2:189. PMID: 31123713.
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    4. Patil I, Sancheti H, Stiles BL, Cadenas E. Brain metabolic and functional alterations in a liver-specific PTEN knockout mouse model. PLoS One. 2018; 13(9):e0204043. PMID: 30235271.
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    5. Chen CY, Chen J, He L, Stiles BL. PTEN: Tumor Suppressor and Metabolic Regulator. Front Endocrinol (Lausanne). 2018; 9:338. PMID: 30038596.
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    6. Lee J, Liu K, Stiles B, Ou JJ. Mitophagy and hepatic cancer stem cells. Autophagy. 2018; 14(4):715-716. PMID: 29313421.
      View in: PubMed
    7. Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles BL, Valasek M, Sander M. Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5. PMID: 29273451.
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    8. Debebe A, Medina V, Chen CY, Mahajan IM, Jia C, Fu D, He L, Zeng N, Stiles BW, Chen CL, Wang M, Aggarwal KR, Peng Z, Huang J, Chen J, Li M, Dong T, Atkins S, Borok Z, Yuan W, Machida K, Ju C, Kahn M, Johnson D, Stiles BL. Wnt/ß-catenin activation and macrophage induction during liver cancer development following steatosis. Oncogene. 2017 10 26; 36(43):6020-6029. PMID: 28671671.
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    9. Jia C, Medina V, Liu C, He L, Qian D, Taojian T, Okamoto CT, Stiles BL. Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development. Hepatol Commun. 2017 Apr; 1(2):153-167. PMID: 29152604.
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    10. He L, Gubbins J, Peng Z, Medina V, Fei F, Asahina K, Wang J, Kahn M, Rountree CB, Stiles BL. Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair. 2016; 9:8. PMID: 27307790.
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    11. Johnson DL, Stiles BL. Maf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab. 2016 10; 27(10):742-750. PMID: 27296319.
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    12. Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152. PMID: 27124661.
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    13. Bayan JA, Peng Z, Zeng N, He L, Chen J, Stiles BL. Crosstalk Between Activated Myofibroblasts and ß Cells in Injured Mouse Pancreas. Pancreas. 2015 Oct; 44(7):1111-20. PMID: 26333110.
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    14. Liu Z, Patil IY, Jiang T, Sancheti H, Walsh JP, Stiles BL, Yin F, Cadenas E. High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity. PLoS One. 2015; 10(5):e0128274. PMID: 26023930.
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    15. Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles BL, Johnson DL. Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789. PMID: 25502566.
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    16. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul 01; 7(332):pe15. PMID: 24985344.
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    17. Wu JB, Shao C, Li X, Li Q, Hu P, Shi C, Li Y, Chen YT, Yin F, Liao CP, Stiles BL, Zhau HE, Shih JC, Chung LW. Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest. 2014 Jul; 124(7):2891-908. PMID: 24865426.
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    18. Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles BL, Ronis MJ, Petersen DR. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 2014; 9(5):e96553. PMID: 24818992.
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    19. Chen WT, Tseng CC, Pfaffenbach K, Kanel G, Luo B, Stiles BL, Lee AS. Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology. 2014 Mar; 59(3):947-57. PMID: 24027047.
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    20. Yang KT, Bayan JA, Zeng N, Aggarwal R, He L, Peng Z, Kassa A, Kim M, Luo Z, Shi Z, Medina V, Boddupally K, Stiles BL. Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice. Diabetologia. 2014 Feb; 57(2):352-61. PMID: 24162585.
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    21. Chen WT, Zhu G, Pfaffenbach K, Kanel G, Stiles B, Lee AS. GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. Oncogene. 2014 Oct 16; 33(42):4997-5005. PMID: 24141775.
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    22. Tsen F, Bhatia A, O'Brien K, Cheng CF, Chen M, Hay N, Stiles B, Woodley DT, Li W. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec; 33(24):4947-59. PMID: 24126057.
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    23. Zeng N, Yang KT, Bayan JA, He L, Aggarwal R, Stiles JW, Hou X, Medina V, Abad D, Palian BM, Al-Abdullah I, Kandeel F, Johnson DL, Stiles BL. PTEN controls ß-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. Aging Cell. 2013 Dec; 12(6):1000-11. PMID: 23826727.
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    24. Li Y, He L, Zeng N, Sahu D, Cadenas E, Shearn C, Li W, Stiles BL. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor a (ERRa). J Biol Chem. 2013 Aug 30; 288(35):25007-24. PMID: 23836899.
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    25. Li C, Li Y, He L, Agarwal AR, Zeng N, Cadenas E, Stiles BL. PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med. 2013 Jul; 60:29-40. PMID: 23376468.
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    26. Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, Lin LI, Ann DK. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy. 2012 Oct; 8(10):1477-93. PMID: 22906967.
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    27. Ding W, Dang H, You H, Steinway S, Takahashi Y, Wang HG, Liao J, Stiles B, Albert R, Rountree CB. miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma. Oncogenesis. 2012 Jun 11; 1:e15. PMID: 23552699.
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    28. Moon BC, Hernandez-Ono A, Stiles B, Wu H, Ginsberg HN. Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):236-46. PMID: 22155452.
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    29. Zeng N, Li Y, He L, Xu X, Galicia V, Deng C, Stiles BL. Adaptive basal phosphorylation of eIF2a is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Mol Cancer Res. 2011 Dec; 9(12):1708-17. PMID: 22009178.
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    30. Ko KS, Tomasi ML, Iglesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles BL, Li TW, Yang H, Martínez-Chantar ML, Mato JM, Lu SC. Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology. 2010 Dec; 52(6):2096-108. PMID: 20890892.
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    31. Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82. PMID: 20837017.
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    32. Ding W, You H, Dang H, LeBlanc F, Galicia V, Lu SC, Stiles B, Rountree CB. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology. 2010 Sep; 52(3):945-53. PMID: 20564331.
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    33. He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles BL. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol. 2010 May; 176(5):2302-8. PMID: 20348245.
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    34. Zeng N, Bayan JA, He L, Stiles B. The Role of PTEN in ß-Cell Growth. Open Endocrinol J. 2010; 4:23-32. PMID: 23853672.
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    35. Stiles BL. PI-3-K and AKT: Onto the mitochondria. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1276-82. PMID: 19720099.
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    36. Rountree CB, Ding W, He L, Stiles B. Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells. 2009 Feb; 27(2):290-9. PMID: 19008348.
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    37. Stiles BL. Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles. Int J Biochem Cell Biol. 2009 Apr; 41(4):757-61. PMID: 18950730.
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    38. Valamehr B, Jonas SJ, Polleux J, Qiao R, Guo S, Gschweng EH, Stiles B, Kam K, Luo TJ, Witte ON, Liu X, Dunn B, Wu H. Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14459-64. PMID: 18791068.
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    39. Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006 Jul; 116(7):1843-52. PMID: 16767220.
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    40. Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006 Apr; 26(7):2772-81. PMID: 16537919.
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    41. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95. PMID: 16169464.
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    42. Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005 Mar; 25(6):2498-510. PMID: 15743841.
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    43. Stiles B, Groszer M, Wang S, Jiao J, Wu H. PTENless means more. Dev Biol. 2004 Sep 15; 273(2):175-84. PMID: 15328005.
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    44. Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS. MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004 Apr; 11(7):609-18. PMID: 14724687.
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    45. Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2082-7. PMID: 14769918.
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    46. Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol. 2002 Jun; 22(11):3842-51. PMID: 11997518.
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    47. Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10314-9. PMID: 11504908.
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