Frank Gonzalez

Title(s)Assistant Professor of Clinical Pediatrics
SchoolKeck School of Medicine of Usc
Address4650 Sunset Blvd.
Off Campus
Los Angeles CA 90027
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression. J Clin Invest. 2024 Apr 01; 134(7). Yan T, Yan N, Xia Y, Sawaswong V, Zhu X, Dias HB, Aibara D, Takahashi S, Hamada K, Saito Y, Li G, Liu H, Yan H, Velenosi TJ, Krausz KW, Huang J, Kimura S, Rotman Y, Qu A, Hao H, Gonzalez FJ. PMID: 38557493; PMCID: PMC10977981.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function. Acta Pharmacol Sin. 2023 Nov; 44(11):2184-2200. Zhu XX, Wang X, Jiao SY, Liu Y, Shi L, Xu Q, Wang JJ, Chen YE, Zhang Q, Song YT, Wei M, Yu BQ, Fielitz J, Gonzalez FJ, Du J, Qu AJ. PMID: 37328648; PMCID: PMC10618178.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence. Int J Biol Sci. 2023; 19(7):2067-2080. Chen P, Tian J, Zhou Y, Chen Y, Zhang H, Jiao T, Huang M, Zhang H, Huang P, Yu AM, Gonzalez FJ, Bi H. PMID: 37151873; PMCID: PMC10158022.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice. Nat Commun. 2023 04 01; 14(1):1829. Zhao Q, Dai MY, Huang RY, Duan JY, Zhang T, Bao WM, Zhang JY, Gui SQ, Xia SM, Dai CT, Tang YM, Gonzalez FJ, Li F. PMID: 37005411; PMCID: PMC10067939.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    5. Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs. ACS Pharmacol Transl Sci. 2023 Mar 10; 6(3):422-446. Park JE, Lee H, Oliva P, Kirsch K, Kim B, Ahn JI, Alverez CN, Gaikwad S, Krausz KW, O'Connor R, Rai G, Simeonov A, Mock BA, Gonzalez FJ, Lee KS, Jacobson KA. PMID: 36926457; PMCID: PMC10012257.
      View in: PubMed   Mentions: 1  
    6. Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nat Commun. 2023 02 10; 14(1):755. Sun L, Zhang Y, Cai J, Rimal B, Rocha ER, Coleman JP, Zhang C, Nichols RG, Luo Y, Kim B, Chen Y, Krausz KW, Harris CC, Patterson AD, Zhang Z, Takahashi S, Gonzalez FJ. PMID: 36765047; PMCID: PMC9918522.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins. Nat Commun. 2022 Nov 26; 13(1):7303. Nanduri R, Furusawa T, Lobanov A, He B, Xie C, Dadkhah K, Kelly MC, Gavrilova O, Gonzalez FJ, Bustin M. PMID: 36435799; PMCID: PMC9701217.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting. Cell Rep. 2022 10 25; 41(4):111547. Wei F, Gong L, Lu S, Zhou Y, Liu L, Duan Z, Xiang R, Gonzalez FJ, Li G. PMID: 36288692; PMCID: PMC9671760.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer. NPJ Precis Oncol. 2022 Oct 07; 6(1):70. Velenosi TJ, Krausz KW, Hamada K, Dorsey TH, Ambs S, Takahashi S, Gonzalez FJ. PMID: 36207498; PMCID: PMC9547066.
      View in: PubMed   Mentions: 1  
    10. The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice. J Biol Chem. 2022 11; 298(11):102530. Wang XX, Xie C, Libby AE, Ranjit S, Levi J, Myakala K, Bhasin K, Jones BA, Orlicky DJ, Takahashi S, Dvornikov A, Kleiner DE, Hewitt SM, Adorini L, Kopp JB, Krausz KW, Rosenberg A, McManaman JL, Robertson CE, Ir D, Frank DN, Luo Y, Gonzalez FJ, Gratton E, Levi M. PMID: 36209823; PMCID: PMC9638804.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    11. Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal. Cell Stem Cell. 2022 09 01; 29(9):1366-1381.e9. Chen L, Jiao T, Liu W, Luo Y, Wang J, Guo X, Tong X, Lin Z, Sun C, Wang K, He Y, Zhang Y, Xu H, Wang J, Zuo J, Ding Q, He S, Gonzalez FJ, Xie C. PMID: 36055192; PMCID: PMC10673678.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    12. Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver. Mol Cell Endocrinol. 2022 11 01; 557:111722. Kim D, Kim B, Brocker CN, Karri K, Waxman DJ, Gonzalez FJ. PMID: 35917881; PMCID: PMC9561029.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Critical role of peroxisome proliferator-activated receptor α in promoting platelet hyperreactivity and thrombosis under hyperlipidemia. Haematologica. 2022 06 01; 107(6):1358-1373. Li L, Zhou J, Wang S, Jiang L, Chen X, Zhou Y, Li J, Shi J, Liu P, Shu Z, Gonzalez FJ, Liu A, Hu H. PMID: 34615341; PMCID: PMC9152986.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. Hepatology. 2023 01 01; 77(1):239-255. Yan T, Luo Y, Yan N, Hamada K, Zhao N, Xia Y, Wang P, Zhao C, Qi D, Yang S, Sun L, Cai J, Wang Q, Jiang C, Gavrilova O, Krausz KW, Patel DP, Yu X, Wu X, Hao H, Liu W, Qu A, Gonzalez FJ. PMID: 35460276; PMCID: PMC9970020.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    15. Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation. iScience. 2022 May 20; 25(5):104196. Aibara D, Takahashi S, Yagai T, Kim D, Brocker CN, Levi M, Matsusue K, Gonzalez FJ. PMID: 35479397; PMCID: PMC9036120.
      View in: PubMed   Mentions: 4  
    16. Postprandial Plasma Lipidomics Reveal Specific Alteration of Hepatic-derived Diacylglycerols in Nonalcoholic Fatty Liver Disease. Gastroenterology. 2022 06; 162(7):1990-2003. Velenosi TJ, Ben-Yakov G, Podszun MC, Hercun J, Etzion O, Yang S, Nadal C, Haynes-Williams V, Huang WA, González-Hódar L, Brychta RJ, Takahashi S, Akkaraju V, Krausz KW, Walter M, Cai H, Walter PJ, Muniyappa R, Chen KY, Gonzalez FJ, Rotman Y. PMID: 35283114; PMCID: PMC9117487.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis. Cell Host Microbe. 2022 03 09; 30(3):289-300. Cai J, Sun L, Gonzalez FJ. PMID: 35271802; PMCID: PMC8923532.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    18. Disruption of peroxisome proliferator-activated receptor α in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway. Int J Biol Sci. 2022; 18(6):2317-2328. Zhang Z, Yao T, Zhao N, Liu H, Cheng H, Gonzalez FJ, Wang H, Wang G, Qu A, Wang Y. PMID: 35414769; PMCID: PMC8990472.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity. Hepatology. 2022 08; 76(2):387-403. Xiong H, Zhang C, Han L, Xu T, Saeed K, Han J, Liu J, Klaassen CD, Gonzalez FJ, Lu Y, Zhang Y. PMID: 34870866.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    20. Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis. Food Chem Toxicol. 2022 Feb; 160:112807. Hamada K, Wang P, Xia Y, Yan N, Takahashi S, Krausz KW, Hao H, Yan T, Gonzalez FJ. PMID: 34995708; PMCID: PMC10353774.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    21. YAP-TEAD mediates PPAR α-induced hepatomegaly and liver regeneration in mice. Hepatology. 2022 01; 75(1):74-88. Fan S, Gao Y, Qu A, Jiang Y, Li H, Xie G, Yao X, Yang X, Zhu S, Yagai T, Tian J, Wang R, Gonzalez FJ, Huang M, Bi H. PMID: 34387904; PMCID: PMC10259205.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights. Drug Metab Dispos. 2022 05; 50(5):685-693. Xia Y, Yan M, Wang P, Hamada K, Yan N, Hao H, Gonzalez FJ, Yan T. PMID: 34903587; PMCID: PMC9132099.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    23. The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice. Toxicology. 2022 01 15; 465:153056. Su S, Billy LJ, Chang S, Gonzalez FJ, Patterson AD, Peters JM. PMID: 34861291; PMCID: PMC10292111.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    24. Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 02; 1867(2):159089. Lu D, Liu Y, Luo Y, Zhao J, Feng C, Xue L, Xu J, Wang Q, Yan T, Xiao P, Krausz KW, Gonzalez FJ, Xie C. PMID: 34856412; PMCID: PMC8864892.
      View in: PubMed   Mentions: 1     Fields:    
    25. St. John's Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism. FASEB J. 2021 11; 35(11):e21968. Yan T, Luo Y, Xia Y, Hamada K, Wang Q, Yan N, Krausz KW, Ward JM, Hao H, Wang P, Gonzalez FJ. PMID: 34644426; PMCID: PMC10167919.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. Feedback repression of PPARα signaling by Let-7 microRNA. Cell Rep. 2021 08 10; 36(6):109506. Yagai T, Yan T, Luo Y, Takahashi S, Aibara D, Kim D, Brocker CN, Levi M, Motohashi H, Gonzalez FJ. PMID: 34380035; PMCID: PMC8424520.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. Hepatology. 2021 10; 74(4):1932-1951. Luo Y, Gao Y, Liu W, Yang Y, Jiang J, Wang Y, Tang W, Yang S, Sun L, Cai J, Guo X, Takahashi S, Krausz KW, Qu A, Chen L, Xie C, Gonzalez FJ. PMID: 33896016; PMCID: PMC9942701.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. Intestinal MYC modulates obesity-related metabolic dysfunction. Nat Metab. 2021 07; 3(7):923-939. Luo Y, Yang S, Wu X, Takahashi S, Sun L, Cai J, Krausz KW, Guo X, Dias HB, Gavrilova O, Xie C, Jiang C, Liu W, Gonzalez FJ. PMID: 34211180; PMCID: PMC9944847.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    29. Oleuropein-Induced Acceleration of Cytochrome P450-Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor α. Drug Metab Dispos. 2021 09; 49(9):833-843. Malliou F, Andriopoulou CE, Gonzalez FJ, Kofinas A, Skaltsounis AL, Konstandi M. PMID: 34162688.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    30. FXR-Deoxycholic Acid-TNF-α Axis Modulates Acetaminophen-Induced Hepatotoxicity. Toxicol Sci. 2021 05 27; 181(2):273-284. Yan T, Yan N, Wang H, Yagai T, Luo Y, Takahashi S, Zhao M, Krausz KW, Wang G, Hao H, Gonzalez FJ. PMID: 33662127; PMCID: PMC8163055.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    31. Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling. Nat Commun. 2021 05 12; 12(1):2745. Geiger SS, Traba J, Richoz N, Farley TK, Brooks SR, Petermann F, Wang L, Gonzalez FJ, Sack MN, Siegel RM. PMID: 33980856; PMCID: PMC8115055.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    32. The pathophysiological function of non-gastrointestinal farnesoid X receptor. Pharmacol Ther. 2021 10; 226:107867. Yan N, Yan T, Xia Y, Hao H, Wang G, Gonzalez FJ. PMID: 33895191.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    33. Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver. Cell Mol Gastroenterol Hepatol. 2021; 12(2):585-597. Mooli RGR, Rodriguez J, Takahashi S, Solanki S, Gonzalez FJ, Ramakrishnan SK, Shah YM. PMID: 33798787; PMCID: PMC8258975.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell Death Dis. 2021 02 11; 12(2):174. Xia Y, Wang P, Yan N, Gonzalez FJ, Yan T. PMID: 33574236; PMCID: PMC7878893.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    35. The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer. Nat Rev Gastroenterol Hepatol. 2021 05; 18(5):335-347. Sun L, Cai J, Gonzalez FJ. PMID: 33568795.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    36. Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Nat Commun. 2021 01 12; 12(1):290. Kim JH, Matsubara T, Lee J, Fenollar-Ferrer C, Han K, Kim D, Jia S, Chang CJ, Yang H, Nagano T, Krausz KW, Yim SH, Gonzalez FJ. PMID: 33436590; PMCID: PMC7804329.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    37. Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting. Nat Commun. 2020 11 17; 11(1):5847. Brocker CN, Kim D, Melia T, Karri K, Velenosi TJ, Takahashi S, Aibara D, Bonzo JA, Levi M, Waxman DJ, Gonzalez FJ. PMID: 33203882; PMCID: PMC7673042.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    38. Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1. J Med Chem. 2020 11 25; 63(22):14087-14117. Alverez CN, Park JE, Toti KS, Xia Y, Krausz KW, Rai G, Bang JK, Gonzalez FJ, Jacobson KA, Lee KS. PMID: 33175530; PMCID: PMC7769008.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    39. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorg Med Chem. 2021 01 01; 29:115851. Xia YL, Wang JJ, Li SY, Liu Y, Gonzalez FJ, Wang P, Ge GB. PMID: 33218896; PMCID: PMC7855844.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis. Mol Pharmacol. 2020 12; 98(6):686-694. Tu MJ, Duan Z, Liu Z, Zhang C, Bold RJ, Gonzalez FJ, Kim EJ, Yu AM. PMID: 33051382; PMCID: PMC7673485.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    41. PPARα mediates night neon light-induced weight gain: role of lipid homeostasis. Theranostics. 2020; 10(25):11497-11506. Luo Y, Yang J, Kang J, Chen K, Jin X, Gonzalez FJ, Liu A. PMID: 33052228; PMCID: PMC7545995.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    42. Improved detection and precise relative quantification of the urinary cancer metabolite biomarkers - Creatine riboside, creatinine riboside, creatine and creatinine by UPLC-ESI-MS/MS: Application to the NCI-Maryland cohort population controls and lung cancer cases. J Pharm Biomed Anal. 2020 Nov 30; 191:113596. Patel DP, Pauly GT, Tada T, Parker AL, Toulabi L, Kanke Y, Oike T, Krausz KW, Gonzalez FJ, Harris CC. PMID: 32937240; PMCID: PMC7756200.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    43. Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice. Toxicol Lett. 2020 Oct 15; 333:290-302. Zhao J, Xie C, Wang K, Takahashi S, Krausz KW, Lu D, Wang Q, Luo Y, Gong X, Mu X, Wang Q, Su S, Gonzalez FJ. PMID: 32835833; PMCID: PMC7783549.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    44. Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation. Drug Metab Dispos. 2020 09; 48(9):830-839. Jiao T, Yao X, Zhao Y, Zhou Y, Gao Y, Fan S, Chen P, Li X, Jiang Y, Yang X, Gonzalez FJ, Huang M, Bi H. PMID: 32561593; PMCID: PMC7497622.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    45. A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics. 2020; 10(16):7193-7210. Chen Y, Zhou Y, Han F, Zhao Y, Tu M, Wang Y, Huang C, Fan S, Chen P, Yao X, Guan L, Yu AM, Gonzalez FJ, Huang M, Bi H. PMID: 32641987; PMCID: PMC7330864.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    46. Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice. J Endocrinol. 2020 05; 245(2):301-314. Konstandi M, Andriopoulou CE, Cheng J, Gonzalez FJ. PMID: 32171179; PMCID: PMC7202972.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    47. A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice. Carcinogenesis. 2020 04 22; 41(2):159-170. Hu X, Wang X, Jia F, Tanaka N, Kimura T, Nakajima T, Sato Y, Moriya K, Koike K, Gonzalez FJ, Nakayama J, Aoyama T. PMID: 31300810; PMCID: PMC8456504.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    48. Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. Aging (Albany NY). 2020 04 14; 12(8):6733-6755. Wang Y, Yu T, Zhou Y, Wang S, Zhou X, Wang L, Ou T, Chen Y, Zhou Y, Zhang H, Wang Y, Fan X, Chen P, Gonzalez FJ, Yu A, Huang P, Huang M, Bi H. PMID: 32289751; PMCID: PMC7202531.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    49. PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice. Int J Mol Sci. 2020 Mar 17; 21(6). Wang Y, Nakajima T, Gonzalez FJ, Tanaka N. PMID: 32192216; PMCID: PMC7139552.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    50. Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites. Hum Genomics. 2020 03 11; 14(1):10. Brocker CN, Velenosi T, Flaten HK, McWilliams G, McDaniel K, Shelton SK, Saben J, Krausz KW, Gonzalez FJ, Monte AA. PMID: 32160915; PMCID: PMC7066769.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    51. SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis. Nat Commun. 2020 01 13; 11(1):240. Zhou J, Cui S, He Q, Guo Y, Pan X, Zhang P, Huang N, Ge C, Wang G, Gonzalez FJ, Wang H, Hao H. PMID: 31932588; PMCID: PMC6957516.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    52. Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis. Free Radic Biol Med. 2020 02 20; 148:33-41. Zhang Y, Yan T, Sun D, Xie C, Wang T, Liu X, Wang J, Wang Q, Luo Y, Wang P, Yagai T, Krausz KW, Yang X, Gonzalez FJ. PMID: 31874248; PMCID: PMC7376370.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    53. Herbal drug discovery for the treatment of nonalcoholic fatty liver disease. Acta Pharm Sin B. 2020 Jan; 10(1):3-18. Yan T, Yan N, Wang P, Xia Y, Hao H, Wang G, Gonzalez FJ. PMID: 31993304; PMCID: PMC6977016.
      View in: PubMed   Mentions: 57  
    54. Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. Cell. 2019 08 22; 178(5):1102-1114.e17. Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE, Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M. PMID: 31442403; PMCID: PMC7357241.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    55. Withaferin A Improves Nonalcoholic Steatohepatitis in Mice. J Pharmacol Exp Ther. 2019 11; 371(2):360-374. Patel DP, Yan T, Kim D, Dias HB, Krausz KW, Kimura S, Gonzalez FJ. PMID: 31420528; PMCID: PMC6800446.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    56. Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on α-synuclein protein levels. Biochem Pharmacol. 2019 10; 168:429-437. González-Barbosa E, García-Aguilar R, Vega L, Cabañas-Cortés MA, Gonzalez FJ, Segovia J, Morales-Lázaro SL, Cisneros B, Elizondo G. PMID: 31404530; PMCID: PMC7376371.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    57. Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 10; 1864(10):1396-1411. Xie C, Takahashi S, Brocker CN, He S, Chen L, Xie G, Jang K, Gao X, Krausz KW, Qu A, Levi M, Gonzalez FJ. PMID: 31195146; PMCID: PMC7423166.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    58. Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6. Gastroenterology. 2019 09; 157(3):744-759.e4. Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ. PMID: 31154022; PMCID: PMC7388731.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    59. Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation. Hepatology. 2019 07; 70(1):154-167. Kim D, Brocker CN, Takahashi S, Yagai T, Kim T, Xie G, Wang H, Qu A, Gonzalez FJ. PMID: 30697791; PMCID: PMC6597269.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    60. Hepatic metabolic adaptation in a murine model of glutathione deficiency. Chem Biol Interact. 2019 Apr 25; 303:1-6. Chen Y, Golla S, Garcia-Milian R, Thompson DC, Gonzalez FJ, Vasiliou V. PMID: 30794799; PMCID: PMC6743730.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    61. Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling. Mol Cell Proteomics. 2019 03; 18(3):520-533. Zhao Q, Liu F, Cheng Y, Xiao XR, Hu DD, Tang YM, Bao WM, Yang JH, Jiang T, Hu JP, Gonzalez FJ, Li F. PMID: 30617157; PMCID: PMC6398203.
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    62. Endothelial Cell-Targeted Deletion of PPARγ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue. J Pharmacol Exp Ther. 2019 03; 368(3):514-523. Akiyama TE, Skelhorne-Gross GE, Lightbody ED, Rubino RE, Shi JY, McNamara LA, Sharma N, Zycband EI, Gonzalez FJ, Liu H, Woods JW, Chang CH, Berger JP, Nicol CJB. PMID: 30606762.
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    63. A systemic workflow for profiling metabolome and lipidome in tissue. J Chromatogr A. 2019 Mar 29; 1589:105-115. Lu D, Xue L, Feng C, Jin Y, Wu C, Xie C, Gonzalez FJ, Wang G, Zhou Z. PMID: 30638710; PMCID: PMC6628932.
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    64. Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice. Hepatology. 2019 01; 69(1):343-358. Jiang Y, Feng D, Ma X, Fan S, Gao Y, Fu K, Wang Y, Sun J, Yao X, Liu C, Zhang H, Xu L, Liu A, Gonzalez FJ, Yang Y, Gao B, Huang M, Bi H. PMID: 30048004; PMCID: PMC6324985.
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    65. The role of hypoxia-inducible factors in metabolic diseases. Nat Rev Endocrinol. 2018 12; 15(1):21-32. Gonzalez FJ, Xie C, Jiang C. PMID: 30275460; PMCID: PMC6624429.
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    66. Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ. Mol Cell Biol. 2018 12 15; 38(24). Sasaki S, Urabe M, Maeda T, Suzuki J, Irie R, Suzuki M, Tomaru Y, Sakaguchi M, Gonzalez FJ, Inoue Y. PMID: 30224520; PMCID: PMC6275183.
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    67. Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice. Arch Toxicol. 2019 01; 93(1):149-161. Lu Y, Harada M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Kyogashima M, Gonzalez FJ, Aoyama T. PMID: 30341732; PMCID: PMC6661123.
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    68. Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis. EBioMedicine. 2018 Nov; 37:322-333. Wang H, Ge C, Zhou J, Guo Y, Cui S, Huang N, Yan T, Cao L, Che Y, Zheng Q, Zheng X, Gonzalez FJ, Wang G, Hao H. PMID: 30337250; PMCID: PMC6286639.
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    69. Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development. Hepatol Commun. 2018 Dec; 2(12):1567-1582. Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ. PMID: 30556042; PMCID: PMC6287584.
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    70. Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice. J Lipid Res. 2018 11; 59(11):2140-2152. Brocker CN, Patel DP, Velenosi TJ, Kim D, Yan T, Yue J, Li G, Krausz KW, Gonzalez FJ. PMID: 30158201; PMCID: PMC6210912.
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    71. Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation. Drug Metab Dispos. 2018 09; 46(9):1310-1319. Yan T, Wang H, Cao L, Wang Q, Takahashi S, Yagai T, Li G, Krausz KW, Wang G, Gonzalez FJ, Hao H. PMID: 29959134; PMCID: PMC6081736.
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    72. Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism. Hepatology. 2018 10; 68(4):1574-1588. Pathak P, Xie C, Nichols RG, Ferrell JM, Boehme S, Krausz KW, Patterson AD, Gonzalez FJ, Chiang JYL. PMID: 29486523; PMCID: PMC6111007.
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    73. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis. Drug Metab Dispos. 2018 07; 46(7):1030-1040. Zhang Y, Yan T, Sun D, Xie C, Zheng Y, Zhang L, Yagai T, Krausz KW, Bisson WH, Yang X, Gonzalez FJ. PMID: 29691238; PMCID: PMC6003592.
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    74. Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643. J Gastroenterol Hepatol. 2018 May; 33(5):1138-1145. Li G, Brocker CN, Xie C, Yan T, Noguchi A, Krausz KW, Xiang R, Gonzalez FJ. PMID: 29141109; PMCID: PMC6334298.
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    75. Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89]. Mol Metab. 2018 03; 9:217-219. Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ. PMID: 29396375; PMCID: PMC5870094.
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    76. Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice. Hepatology. 2018 03; 67(3):1071-1087. Ou-Yang Q, Lin XM, Zhu YJ, Zheng B, Li L, Yang YC, Hou GJ, Chen X, Luo GJ, Huo F, Leng QB, Gonzalez FJ, Jiang XQ, Wang HY, Chen L. PMID: 28960380; PMCID: PMC6661113.
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    77. Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In Vitro. Drug Metab Dispos. 2018 04; 46(4):336-345. Xie C, Gao X, Sun D, Zhang Y, Krausz KW, Qin X, Gonzalez FJ. PMID: 29363499; PMCID: PMC5829541.
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    78. Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice. J Biol Chem. 2018 01 05; 293(1):1-17. Choi S, Neequaye P, French SW, Gonzalez FJ, Gyamfi MA. PMID: 29123032; PMCID: PMC5766906.
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    79. Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha. Mol Metab. 2018 01; 7:80-89. Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ. PMID: 29146411; PMCID: PMC5784329.
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    80. FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018 01; 29(1):118-137. Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D'Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M. PMID: 29089371; PMCID: PMC5748904.
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    81. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov; 23(11):1298-1308. Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ. PMID: 29035368; PMCID: PMC6410352.
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    82. Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota. Cell Metab. 2017 Oct 03; 26(4):672-685.e4. Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ. PMID: 28918936; PMCID: PMC5668683.
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    83. Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice. Biomol Ther (Seoul). 2017 Sep 01; 25(5):504-510. Kim T, Wahyudi LD, Gonzalez FJ, Kim JH. PMID: 28190320; PMCID: PMC5590794.
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    84. Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. Biochim Biophys Acta Mol Basis Dis. 2017 12; 1863(12):3170-3182. Tanaka N, Takahashi S, Hu X, Lu Y, Fujimori N, Golla S, Fang ZZ, Aoyama T, Krausz KW, Gonzalez FJ. PMID: 28844958; PMCID: PMC5675002.
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    85. A Western diet-induced mouse model reveals a possible mechanism by which metformin decreases obesity. Eur J Clin Pharmacol. 2017 Oct; 73(10):1337-1339. Gonzalez FJ, Jiang C. PMID: 28831566; PMCID: PMC5693664.
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    86. Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway. Toxicol Sci. 2017 08 01; 158(2):334-346. Takahashi S, Tanaka N, Golla S, Fukami T, Krausz KW, Polunas MA, Weig BC, Masuo Y, Xie C, Jiang C, Gonzalez FJ. PMID: 28505368; PMCID: PMC5837376.
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    87. Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung. Biochem Biophys Res Commun. 2017 09 16; 491(2):271-276. Kim JH, Yamaori S, Tanabe T, Takagi M, Matsubara T, Okamoto M, Kimura S, Gonzalez FJ. PMID: 28739257; PMCID: PMC6291199.
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    88. Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation. J Hypertens. 2017 07; 35(7):1390-1401. Idris-Khodja N, Ouerd S, Trindade M, Gornitsky J, Rehman A, Barhoumi T, Offermanns S, Gonzalez FJ, Neves MF, Paradis P, Schiffrin EL. PMID: 28234672; PMCID: PMC6338076.
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    89. Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption. Toxicology. 2017 07 01; 386:133-142. Wang H, Fang ZZ, Meng R, Cao YF, Tanaka N, Krausz KW, Gonzalez FJ. PMID: 28549656; PMCID: PMC5594256.
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    90. Inflammation is independent of steatosis in a murine model of steatohepatitis. Hepatology. 2017 07; 66(1):108-123. Wang W, Xu MJ, Cai Y, Zhou Z, Cao H, Mukhopadhyay P, Pacher P, Zheng S, Gonzalez FJ, Gao B. PMID: 28220523; PMCID: PMC5481491.
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    91. Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice. PLoS One. 2017; 12(5):e0177953. Patel DP, Krausz KW, Xie C, Beyoglu D, Gonzalez FJ, Idle JR. PMID: 28520815; PMCID: PMC5433781.
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    92. Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes. Xenobiotica. 2018 Apr; 48(4):357-367. Wang L, Hong X, Yao Z, Dai Y, Zhao G, Qin Z, Wu B, Gonzalez FJ, Yao X. PMID: 28443723; PMCID: PMC6300989.
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    93. Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. Sci Rep. 2017 05 11; 7(1):1748. Sheng L, Jena PK, Liu HX, Kalanetra KM, Gonzalez FJ, French SW, Krishnan VV, Mills DA, Wan YY. PMID: 28496104; PMCID: PMC5431816.
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    94. An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function. J Biol Chem. 2017 06 23; 292(25):10574-10585. Morimoto A, Kannari M, Tsuchida Y, Sasaki S, Saito C, Matsuta T, Maeda T, Akiyama M, Nakamura T, Sakaguchi M, Nameki N, Gonzalez FJ, Inoue Y. PMID: 28465351; PMCID: PMC5481564.
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    95. 2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice. Hypertension. 2017 06; 69(6):1104-1112. Pingili AK, Davidge KN, Thirunavukkarasu S, Khan NS, Katsurada A, Majid DSA, Gonzalez FJ, Navar LG, Malik KU. PMID: 28416584; PMCID: PMC5426976.
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    96. Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis. Cell Metab. 2017 Apr 04; 25(4):856-867.e5. Hao H, Cao L, Jiang C, Che Y, Zhang S, Takahashi S, Wang G, Gonzalez FJ. PMID: 28380377; PMCID: PMC6624427.
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    97. Potential role of CYP1B1 in the development and treatment of metabolic diseases. Pharmacol Ther. 2017 Oct; 178:18-30. Li F, Zhu W, Gonzalez FJ. PMID: 28322972; PMCID: PMC5600638.
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    98. Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure. Radiat Res. 2017 05; 187(5):612-629. Golla S, Golla JP, Krausz KW, Manna SK, Simillion C, Beyoglu D, Idle JR, Gonzalez FJ. PMID: 28467754; PMCID: PMC5539505.
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    99. Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease. Dig Dis. 2017; 35(3):178-184. Gonzalez FJ, Jiang C, Xie C, Patterson AD. PMID: 28249275; PMCID: PMC6595218.
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    100. Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 01; 312(3):G283-G299. Brocker CN, Yue J, Kim D, Qu A, Bonzo JA, Gonzalez FJ. PMID: 28082284; PMCID: PMC5401987.
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    101. An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice. Diabetes. 2017 03; 66(3):613-626. Xie C, Jiang C, Shi J, Gao X, Sun D, Sun L, Wang T, Takahashi S, Anitha M, Krausz KW, Patterson AD, Gonzalez FJ. PMID: 28223344; PMCID: PMC5319721.
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    102. Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy. J Biol Chem. 2016 Nov 25; 291(48):25255-25263. Koga T, Yao PL, Goudarzi M, Murray IA, Balandaram G, Gonzalez FJ, Perdew GH, Fornace AJ, Peters JM. PMID: 27765815; PMCID: PMC5122791.
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    103. Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans. J Lipid Res. 2016 12; 57(12):2130-2137. Takahashi S, Fukami T, Masuo Y, Brocker CN, Xie C, Krausz KW, Wolf CR, Henderson CJ, Gonzalez FJ. PMID: 27638959; PMCID: PMC5321228.
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    104. An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease. Gastroenterology. 2016 11; 151(5):845-859. Gonzalez FJ, Jiang C, Patterson AD. PMID: 27639801; PMCID: PMC5159222.
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    105. Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation. Mol Endocrinol. 2016 Oct; 30(10):1070-1080. Hashiguchi T, Arakawa S, Takahashi S, Gonzalez FJ, Sueyoshi T, Negishi M. PMID: 27571290; PMCID: PMC5045495.
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    106. The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4. Biochem Pharmacol. 2016 Nov 01; 119:93-104. Gao X, Xie C, Wang Y, Luo Y, Yagai T, Sun D, Qin X, Krausz KW, Gonzalez FJ. PMID: 27569425; PMCID: PMC5061623.
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    107. Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis. Drug Metab Dispos. 2016 May; 44(5):720-31. Yan T, Wang H, Zhao M, Yagai T, Chai Y, Krausz KW, Xie C, Cheng X, Zhang J, Che Y, Li F, Wu Y, Brocker CN, Gonzalez FJ, Wang G, Hao H. PMID: 26965985; PMCID: PMC4851304.
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    108. 6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice. Hypertension. 2016 May; 67(5):916-26. Pingili AK, Thirunavukkarasu S, Kara M, Brand DD, Katsurada A, Majid DS, Navar LG, Gonzalez FJ, Malik KU. PMID: 26928804; PMCID: PMC4833582.
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    109. Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis. Gut. 2016 07; 65(7):1186-201. Yang Y, Lin X, Lu X, Luo G, Zeng T, Tang J, Jiang F, Li L, Cui X, Huang W, Hou G, Chen X, Ouyang Q, Tang S, Sun H, Chen L, Gonzalez FJ, Wu M, Cong W, Chen L, Wang H. PMID: 26860770; PMCID: PMC6624432.
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    110. HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling. Cell Metab. 2016 Mar 08; 23(3):505-16. Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM. PMID: 26853750; PMCID: PMC4785079.
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    111. Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression. Toxicol Appl Pharmacol. 2016 Jan 15; 291:21-7. Fang ZZ, Zhang D, Cao YF, Xie C, Lu D, Sun DX, Tanaka N, Jiang C, Chen Q, Chen Y, Wang H, Gonzalez FJ. PMID: 26706406; PMCID: PMC4718832.
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    112. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun. 2015 Dec 15; 6:10166. Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ. PMID: 26670557; PMCID: PMC4682112.
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    113. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension. 2016 Jan; 67(1):206-13. Song CY, Ghafoor K, Ghafoor HU, Khan NS, Thirunavukkarasu S, Jennings BL, Estes AM, Zaidi S, Bridges D, Tso P, Gonzalez FJ, Malik KU. PMID: 26573711; PMCID: PMC4672747.
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    114. Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver. J Biol Chem. 2015 Dec 25; 290(52):30855-65. Matsuo S, Ogawa M, Muckenthaler MU, Mizui Y, Sasaki S, Fujimura T, Takizawa M, Ariga N, Ozaki H, Sakaguchi M, Gonzalez FJ, Inoue Y. PMID: 26527688; PMCID: PMC4692214.
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    115. Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015 Sep 29; 6:8186. Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD. PMID: 26416771; PMCID: PMC4598356.
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    116. Metabolic mapping of A3 adenosine receptor agonist MRS5980. Biochem Pharmacol. 2015 Sep 15; 97(2):215-23. Fang ZZ, Tosh DK, Tanaka N, Wang H, Krausz KW, O'Connor R, Jacobson KA, Gonzalez FJ. PMID: 26212548; PMCID: PMC4581425.
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    117. Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity. J Pharmacol Exp Ther. 2015 Sep; 354(3):459-70. Spruiell K, Gyamfi AA, Yeyeodu ST, Richardson RM, Gonzalez FJ, Gyamfi MA. PMID: 26159875; PMCID: PMC4538875.
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    118. Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. Gastroenterology. 2015 Oct; 149(4):1030-41.e6. Xu MJ, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara T, Mukhopadhyay P, Kimura S, Pacher P, Gonzalez FJ, Bataller R, Gao B. PMID: 26099526; PMCID: PMC4584194.
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    119. Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis. Phytother Res. 2015 Oct; 29(10):1658-64. Song JH, Cui L, An LB, Li WT, Fang ZZ, Zhang YY, Dong PP, Wu X, Wang LX, Gonzalez FJ, Sun XY, Zhao DW. PMID: 26084208; PMCID: PMC6594156.
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    120. Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. Biochim Biophys Acta. 2015 Aug; 1849(8):919-29. Cicchini C, de Nonno V, Battistelli C, Cozzolino AM, De Santis Puzzonia M, Ciafrè SA, Brocker C, Gonzalez FJ, Amicone L, Tripodi M. PMID: 26003733; PMCID: PMC6319628.
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    121. GC-MS metabolomics on PPARα-dependent exacerbation of colitis. Mol Biosyst. 2015 May; 11(5):1329-37. Gu X, Song Y, Chai Y, Lu F, Gonzalez FJ, Fan G, Qi Y. PMID: 25790429; PMCID: PMC6334306.
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    122. 6β-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice. Hypertension. 2015 Jun; 65(6):1279-87. Pingili AK, Kara M, Khan NS, Estes AM, Lin Z, Li W, Gonzalez FJ, Malik KU. PMID: 25870196; PMCID: PMC4433413.
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    123. Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity. Expert Opin Drug Metab Toxicol. 2015 Jun; 11(6):869-81. Gonzalez FJ, Fang ZZ, Ma X. PMID: 25836352; PMCID: PMC4706076.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    124. Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. Environ Health Perspect. 2015 Jul; 123(7):679-88. Zhang L, Nichols RG, Correll J, Murray IA, Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD. PMID: 25768209; PMCID: PMC4492271.
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    125. Modulation of colon cancer by nutmeg. J Proteome Res. 2015 Apr 03; 14(4):1937-46. Li F, Yang XW, Krausz KW, Nichols RG, Xu W, Patterson AD, Gonzalez FJ. PMID: 25712450; PMCID: PMC6334305.
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    126. Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders. J Biol Chem. 2015 Apr 17; 290(16):10309-24. Ghosh A, Jana M, Modi K, Gonzalez FJ, Sims KB, Berry-Kravis E, Pahan K. PMID: 25750174; PMCID: PMC4400343.
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    127. Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity. J Hepatol. 2015 Jun; 62(6):1234-6. Gonzalez FJ, Jiang C, Bisson WH, Patterson AD. PMID: 25747705; PMCID: PMC6346267.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    128. Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta. 2015 Jul; 1852(7):1242-52. Tanaka N, Takahashi S, Zhang Y, Krausz KW, Smith PB, Patterson AD, Gonzalez FJ. PMID: 25736301; PMCID: PMC4433820.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    129. Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism. Lab Invest. 2015 May; 95(5):515-24. Teranishi Y, Matsubara T, Krausz KW, Le TT, Gonzalez FJ, Yoshizato K, Ikeda K, Kawada N. PMID: 25686096; PMCID: PMC6331008.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    130. Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARα(PAC) mice due to dysregulated bile acid synthesis. Oncotarget. 2015; 6(12):9686-700. Liu HX, Hu Y, French SW, Gonzalez FJ, Wan YJ. PMID: 25991671; PMCID: PMC4496390.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    131. Application of mass spectrometry-based metabolomics in identification of early noninvasive biomarkers of alcohol-induced liver disease using mouse model. Adv Exp Med Biol. 2015; 815:217-38. Manna SK, Thompson MD, Gonzalez FJ. PMID: 25427910; PMCID: PMC6335647.
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    132. Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine. Drug Metab Dispos. 2015 Mar; 43(3):317-24. Fan X, Chen P, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Qu A, Gonzalez FJ, Huang M, Bi H. PMID: 25534769; PMCID: PMC6067383.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    133. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015 Jan; 143(1):107-15. Jiang Y, Fan X, Wang Y, Chen P, Zeng H, Tan H, Gonzalez FJ, Huang M, Bi H. PMID: 25319358; PMCID: PMC4334815.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    134. Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J Pharmacol Exp Ther. 2014 Dec; 351(3):559-67. Cheng J, Fang ZZ, Nagaoka K, Okamoto M, Qu A, Tanaka N, Kimura S, Gonzalez FJ. PMID: 25277138; PMCID: PMC4244584.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    135. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014 Nov 05; 223:80-6. Liu A, Tanaka N, Sun L, Guo B, Kim JH, Krausz KW, Fang Z, Jiang C, Yang J, Gonzalez FJ. PMID: 25265579; PMCID: PMC4376644.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    136. Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. Drug Metab Dispos. 2014 Dec; 42(12):1982-90. Fan X, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Chen P, Qu A, Gonzalez FJ, Huang M, Bi H. PMID: 25217484; PMCID: PMC6067381.
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    137. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun. 2014 Sep 03; 5:4573. Zhou X, Cao L, Jiang C, Xie Y, Cheng X, Krausz KW, Qi Y, Sun L, Shah YM, Gonzalez FJ, Wang G, Hao H. PMID: 25183423; PMCID: PMC4164778.
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    138. Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta. 2014 Nov; 1841(11):1596-607. Tanaka N, Takahashi S, Fang ZZ, Matsubara T, Krausz KW, Qu A, Gonzalez FJ. PMID: 25178843; PMCID: PMC4188754.
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    139. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis. 2014 Oct; 35(10):2264-72. Bi HC, Pan YZ, Qiu JX, Krausz KW, Li F, Johnson CH, Jiang CT, Gonzalez FJ, Yu AM. PMID: 25115443; PMCID: PMC4178474.
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    140. PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 01; 307(5):G564-73. Qi Y, Jiang C, Tanaka N, Krausz KW, Brocker CN, Fang ZZ, Bredell BX, Shah YM, Gonzalez FJ. PMID: 25035112; PMCID: PMC4154119.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    141. PPARβ/δ activation of CD300a controls intestinal immunity. Sci Rep. 2014 Jun 24; 4:5412. Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J. PMID: 24958459; PMCID: PMC4067692.
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    142. Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation. Mol Cell Biol. 2014 Aug; 34(16):3013-23. Xie L, Xue X, Taylor M, Ramakrishnan SK, Nagaoka K, Hao C, Gonzalez FJ, Shah YM. PMID: 24891620; PMCID: PMC4135598.
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    143. Metabolic profiling of praziquantel enantiomers. Biochem Pharmacol. 2014 Jul 15; 90(2):166-78. Wang H, Fang ZZ, Zheng Y, Zhou K, Hu C, Krausz KW, Sun D, Idle JR, Gonzalez FJ. PMID: 24821110; PMCID: PMC4168258.
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    144. Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys Acta. 2015 Jan; 1851(1):19-29. Qi Y, Jiang C, Cheng J, Krausz KW, Li T, Ferrell JM, Gonzalez FJ, Chiang JY. PMID: 24796972; PMCID: PMC4219936.
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    145. Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice. Hypertension. 2014 Jul; 64(1):134-40. Jennings BL, George LW, Pingili AK, Khan NS, Estes AM, Fang XR, Gonzalez FJ, Malik KU. PMID: 24777982; PMCID: PMC4065791.
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    146. Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer. Cancer Res. 2014 Jun 15; 74(12):3259-70. Mathé EA, Patterson AD, Haznadar M, Manna SK, Krausz KW, Bowman ED, Shields PG, Idle JR, Smith PB, Anami K, Kazandjian DG, Hatzakis E, Gonzalez FJ, Harris CC. PMID: 24736543; PMCID: PMC4100625.
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    147. Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice. Biochem Pharmacol. 2014 Jun 01; 89(3):399-412. Spruiell K, Jones DZ, Cullen JM, Awumey EM, Gonzalez FJ, Gyamfi MA. PMID: 24721462; PMCID: PMC4057797.
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    148. Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity. J Proteome Res. 2014 May 02; 13(5):2679-87. Li F, Jiang C, Larsen MC, Bushkofsky J, Krausz KW, Wang T, Jefcoate CR, Gonzalez FJ. PMID: 24684199; PMCID: PMC4018097.
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    149. LC-MS-based metabolomics: an update. Arch Toxicol. 2014 Aug; 88(8):1491-502. Fang ZZ, Gonzalez FJ. PMID: 24710571; PMCID: PMC6310611.
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    150. In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract. Br J Pharmacol. 2014 Apr; 171(7):1735-46. Fang ZZ, Krausz KW, Nagaoka K, Tanaka N, Gowda K, Amin SG, Perdew GH, Gonzalez FJ. PMID: 24417285; PMCID: PMC3966752.
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    151. Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in keratinocytes. Carcinogenesis. 2014 Jul; 35(7):1602-12. Borland MG, Krishnan P, Lee C, Albrecht PP, Shan W, Bility MT, Marcus CB, Lin JM, Amin S, Gonzalez FJ, Perdew GH, Peters JM. PMID: 24639079; PMCID: PMC4076811.
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    152. Potential role of the vitamin D receptor in control of cholesterol levels. Gastroenterology. 2014 Apr; 146(4):899-902. Gonzalez FJ, Moschetta A. PMID: 24566107; PMCID: PMC6350777.
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    153. Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo. Am J Physiol Endocrinol Metab. 2014 Apr 01; 306(7):E824-37. Bonzo JA, Brocker C, Jiang C, Wang RH, Deng CX, Gonzalez FJ. PMID: 24496310; PMCID: PMC4116399.
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    154. Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis. Mol Cell Biol. 2014 Apr; 34(7):1208-20. Ramakrishnan SK, Taylor M, Qu A, Ahn SH, Suresh MV, Raghavendran K, Gonzalez FJ, Shah YM. PMID: 24421394; PMCID: PMC3993569.
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    155. Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes. Drug Metab Dispos. 2014 Apr; 42(4):492-9. Lee JK, Chung HJ, Fischer L, Fischer J, Gonzalez FJ, Jeong H. PMID: 24408518; PMCID: PMC3965907.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    156. Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014; 9(1):e84583. Ciappio ED, Krausz KW, Rochman M, Furusawa T, Bonzo JA, Tessarollo L, Gonzalez FJ, Bustin M. PMID: 24392144; PMCID: PMC3879345.
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    157. Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3. Hepatology. 2014 Feb; 59(2):695-704. Kim JH, Qu A, Reddy JK, Gao B, Gonzalez FJ. PMID: 23939942; PMCID: PMC3880633.
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    158. Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice. J Lipid Res. 2014 Mar; 55(3):455-65. Cheng J, Fang ZZ, Kim JH, Krausz KW, Tanaka N, Chiang JY, Gonzalez FJ. PMID: 24343899; PMCID: PMC3934730.
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    159. Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. J Biol Chem. 2014 Feb 07; 289(6):3105-13. Koh KH, Pan X, Shen HW, Arnold SL, Yu AM, Gonzalez FJ, Isoherranen N, Jeong H. PMID: 24318876; PMCID: PMC3916516.
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    160. Role of Myc in hepatocellular proliferation and hepatocarcinogenesis. J Hepatol. 2014 Feb; 60(2):331-8. Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ. PMID: 24096051; PMCID: PMC3909877.
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    161. CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. Free Radic Biol Med. 2013 Dec; 65:1238-1245. Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ. PMID: 24064383; PMCID: PMC3859835.
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    162. Role of PPARα and HNF4α in stress-mediated alterations in lipid homeostasis. PLoS One. 2013; 8(8):e70675. Konstandi M, Shah YM, Matsubara T, Gonzalez FJ. PMID: 23967086; PMCID: PMC3743822.
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    163. The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase. J Biol Chem. 2013 Sep 27; 288(39):27898-911. Viswakarma N, Jia Y, Bai L, Gao Q, Lin B, Zhang X, Misra P, Rana A, Jain S, Gonzalez FJ, Zhu YJ, Thimmapaya B, Reddy JK. PMID: 23943624; PMCID: PMC3784705.
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    164. Global metabolomics reveals urinary biomarkers of breast cancer in a mcf-7 xenograft mouse model. Metabolites. 2013 Aug 07; 3(3):658-72. Johnson CH, Manna SK, Krausz KW, Bonzo JA, Divelbiss RD, Hollingshead MG, Gonzalez FJ. PMID: 24958144; PMCID: PMC3901288.
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    165. Cholestasis induces reversible accumulation of periplakin in mouse liver. BMC Gastroenterol. 2013 Jul 13; 13:116. Ito S, Satoh J, Matsubara T, Shah YM, Ahn SH, Anderson CR, Shan W, Peters JM, Gonzalez FJ. PMID: 23849208; PMCID: PMC3716950.
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    166. Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping. Toxicol Sci. 2013 Sep; 135(1):37-47. Cheng J, Chen C, Kristopher KW, Manna SK, Scerba M, Friedman FK, Luecke H, Idle JR, Gonzalez FJ. PMID: 23811823; PMCID: PMC3748767.
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    167. Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. Chem Res Toxicol. 2013 Jul 15; 26(7):1088-96. Patterson AD, Carlson BA, Li F, Bonzo JA, Yoo MH, Krausz KW, Conrad M, Chen C, Gonzalez FJ, Hatfield DL. PMID: 23697945; PMCID: PMC6334300.
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    168. Metabolomics reveals that tumor xenografts induce liver dysfunction. Mol Cell Proteomics. 2013 Aug; 12(8):2126-35. Li F, Patterson AD, Krausz KW, Jiang C, Bi H, Sowers AL, Cook JA, Mitchell JB, Gonzalez FJ. PMID: 23637421; PMCID: PMC3734574.
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    169. Potential role of CYP2D6 in the central nervous system. Xenobiotica. 2013 Nov; 43(11):973-84. Cheng J, Zhen Y, Miksys S, Beyoglu D, Krausz KW, Tyndale RF, Yu A, Idle JR, Gonzalez FJ. PMID: 23614566; PMCID: PMC3750078.
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    170. Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. Arch Toxicol. 2013 Nov; 87(11):1975-1987. Fang ZZ, Krausz KW, Tanaka N, Li F, Qu A, Idle JR, Gonzalez FJ. PMID: 23575800; PMCID: PMC6338077.
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    171. Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B cells via peroxisome proliferator-activated receptor α. J Immunol. 2013 Mar 15; 190(6):2575-84. Wejksza K, Lee-Chang C, Bodogai M, Bonzo J, Gonzalez FJ, Lehrmann E, Becker K, Biragyn A. PMID: 23408836; PMCID: PMC3594535.
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    172. Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity. Evid Based Complement Alternat Med. 2013; 2013:985257. Bi H, Li F, Krausz KW, Qu A, Johnson CH, Gonzalez FJ. PMID: 23431354; PMCID: PMC3575671.
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    173. Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology. J Proteome Res. 2013 Mar 01; 12(3):1369-76. Li F, Pang X, Krausz KW, Jiang C, Chen C, Cook JA, Krishna MC, Mitchell JB, Gonzalez FJ, Patterson AD. PMID: 23301521; PMCID: PMC3594779.
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    174. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat Commun. 2013; 4:2384. Li F, Jiang C, Krausz KW, Li Y, Albert I, Hao H, Fabre KM, Mitchell JB, Patterson AD, Gonzalez FJ. PMID: 24064762; PMCID: PMC6595219.
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    175. Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver. Biol Pharm Bull. 2013; 36(11):1766-72. Aibara D, Matsusue K, Matsuo K, Takiguchi S, Gonzalez FJ, Yamano S. PMID: 24189421; PMCID: PMC7667495.
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    176. Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes. J Biol Chem. 2013 Feb 08; 288(6):3844-57. Jiang C, Kim JH, Li F, Qu A, Gavrilova O, Shah YM, Gonzalez FJ. PMID: 23255598; PMCID: PMC3567639.
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    177. Protective role of vascular smooth muscle cell PPARγ in angiotensin II-induced vascular disease. Cardiovasc Res. 2013 Mar 01; 97(3):562-70. Marchesi C, Rehman A, Rautureau Y, Kasal DA, Briet M, Leibowitz A, Simeone SM, Ebrahimian T, Neves MF, Offermanns S, Gonzalez FJ, Paradis P, Schiffrin EL. PMID: 23250918.
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    178. Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier. PLoS Genet. 2012; 8(11):e1003053. Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG. PMID: 23209428; PMCID: PMC3510057.
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    179. Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice. Drug Metab Dispos. 2013 Feb; 41(2):406-13. Johnson CH, Bonzo JA, Cheng J, Krausz KW, Kang DW, Luecke H, Idle JR, Gonzalez FJ. PMID: 23160821; PMCID: PMC3558860.
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    180. CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid. Toxicol Appl Pharmacol. 2013 Jan 15; 266(2):245-53. Cheng J, Krausz KW, Li F, Ma X, Gonzalez FJ. PMID: 23142471; PMCID: PMC3661416.
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    181. Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. Cell Metab. 2012 Nov 07; 16(5):634-44. Matsubara T, Tanaka N, Krausz KW, Manna SK, Kang DW, Anderson ER, Luecke H, Patterson AD, Shah YM, Gonzalez FJ. PMID: 23140643; PMCID: PMC3496181.
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    182. Metabolic map and bioactivation of the anti-tumour drug noscapine. Br J Pharmacol. 2012 Nov; 167(6):1271-86. Fang ZZ, Krausz KW, Li F, Cheng J, Tanaka N, Gonzalez FJ. PMID: 22671862; PMCID: PMC3504993.
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    183. Reply:. Hepatology. 2012 Nov; 56(5):2009. Tanaka N, Gonzalez FJ. PMID: 23115012; PMCID: PMC4260325.
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    184. Reply to Bile acids in Non-Alcoholic Steato-Hepatitis: inserting nuclear receptors into the circle. Hepatology. 2012 Nov; 56(5):2009. Tanaka N, Gonzalez FJ. PMID: 25505811.
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    185. TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res. 2012 Dec; 53(12):2698-707. Matsubara T, Tanaka N, Sato M, Kang DW, Krausz KW, Flanders KC, Ikeda K, Luecke H, Wakefield LM, Gonzalez FJ. PMID: 23034213; PMCID: PMC3494264.
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    186. Implication of intestinal VDR deficiency in inflammatory bowel disease. Biochim Biophys Acta. 2013 Jan; 1830(1):2118-28. Kim JH, Yamaori S, Tanabe T, Johnson CH, Krausz KW, Kato S, Gonzalez FJ. PMID: 23041070; PMCID: PMC3508150.
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    187. Nuclear receptor control of enterohepatic circulation. Compr Physiol. 2012 Oct; 2(4):2811-28. Gonzalez FJ. PMID: 23720266; PMCID: PMC6608752.
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    188. Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics. Radiat Res. 2012 Oct; 178(4):328-40. Johnson CH, Patterson AD, Krausz KW, Kalinich JF, Tyburski JB, Kang DW, Luecke H, Gonzalez FJ, Blakely WF, Idle JR. PMID: 22954391; PMCID: PMC3498937.
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    189. Challenges and opportunities of metabolomics. J Cell Physiol. 2012 Aug; 227(8):2975-81. Johnson CH, Gonzalez FJ. PMID: 22034100; PMCID: PMC6309313.
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    190. Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. Toxicol Sci. 2012 Oct; 129(2):456-68. Cheng J, Krausz KW, Tanaka N, Gonzalez FJ. PMID: 22790967; PMCID: PMC3491956.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    191. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10504-9. Sarkar K, Cai Z, Gupta R, Parajuli N, Fox-Talbot K, Darshan MS, Gonzalez FJ, Semenza GL. PMID: 22699503; PMCID: PMC3387090.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    192. Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Hepatology. 2012 Jul; 56(1):281-90. Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ. PMID: 22318764; PMCID: PMC3378765.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    193. Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology. 2012 Jul; 56(1):118-29. Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ. PMID: 22290395; PMCID: PMC6371056.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    194. Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis. J Lipid Res. 2012 Aug; 53(8):1625-35. Li F, Patterson AD, Krausz KW, Tanaka N, Gonzalez FJ. PMID: 22665165; PMCID: PMC3540854.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    195. Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol. 2012 Oct; 57(4):860-6. Abdelmegeed MA, Banerjee A, Yoo SH, Jang S, Gonzalez FJ, Song BJ. PMID: 22668639; PMCID: PMC3445664.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    196. Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα. PLoS One. 2012; 7(6):e38104. Safdar H, Cheung KL, Vos HL, Gonzalez FJ, Reitsma PH, Inoue Y, van Vlijmen BJ. PMID: 22675511; PMCID: PMC3365905.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    197. Pregnane X receptor as a target for treatment of inflammatory bowel disorders. Trends Pharmacol Sci. 2012 Jun; 33(6):323-30. Cheng J, Shah YM, Gonzalez FJ. PMID: 22609277; PMCID: PMC3368991.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    198. FXR signaling in the enterohepatic system. Mol Cell Endocrinol. 2013 Apr 10; 368(1-2):17-29. Matsubara T, Li F, Gonzalez FJ. PMID: 22609541; PMCID: PMC3491147.
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    199. Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition. Diabetes. 2012 Jun; 61(6):1479-89. Düfer M, Hörth K, Wagner R, Schittenhelm B, Prowald S, Wagner TF, Oberwinkler J, Lukowski R, Gonzalez FJ, Krippeit-Drews P, Drews G. PMID: 22492528; PMCID: PMC3357280.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    200. Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochem Pharmacol. 2012 May 15; 83(10):1435-44. Li F, Patterson AD, Krausz KW, Dick B, Frey FJ, Gonzalez FJ, Idle JR. PMID: 22387617; PMCID: PMC3665348.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    201. Expression and regulation of human fetal-specific CYP3A7 in mice. Endocrinology. 2012 Mar; 153(3):1453-63. Pang XY, Cheng J, Kim JH, Matsubara T, Krausz KW, Gonzalez FJ. PMID: 22253426; PMCID: PMC3281537.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    202. Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice. J Biol Chem. 2012 Mar 02; 287(10):7345-56. Bonzo JA, Ferry CH, Matsubara T, Kim JH, Gonzalez FJ. PMID: 22241473; PMCID: PMC3293558.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    203. Disruption of endothelial peroxisome proliferator-activated receptor γ accelerates diet-induced atherogenesis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):65-73. Qu A, Shah YM, Manna SK, Gonzalez FJ. PMID: 22015658; PMCID: PMC3649072.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    204. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output. Hepatology. 2011 Oct; 54(4):1303-12. Baghdasaryan A, Claudel T, Gumhold J, Silbert D, Adorini L, Roda A, Vecchiotti S, Gonzalez FJ, Schoonjans K, Strazzabosco M, Fickert P, Trauner M. PMID: 22006858; PMCID: PMC3744065.
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    205. Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes. 2011 Oct; 60(10):2484-95. Jiang C, Qu A, Matsubara T, Chanturiya T, Jou W, Gavrilova O, Shah YM, Gonzalez FJ. PMID: 21873554; PMCID: PMC3178277.
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    206. Xenobiotic metabolomics: major impact on the metabolome. Annu Rev Pharmacol Toxicol. 2012; 52:37-56. Johnson CH, Patterson AD, Idle JR, Gonzalez FJ. PMID: 21819238; PMCID: PMC6300990.
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    207. Farnesoid X receptor represses hepatic human APOA gene expression. J Clin Invest. 2011 Sep; 121(9):3724-34. Chennamsetty I, Claudel T, Kostner KM, Baghdasaryan A, Kratky D, Levak-Frank S, Frank S, Gonzalez FJ, Trauner M, Kostner GM. PMID: 21804189; PMCID: PMC3163948.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    208. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol. 2011 Jul; 9(7):e1001112. Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D. PMID: 21814490; PMCID: PMC3144184.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    209. Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis. J Biol Chem. 2011 Aug 26; 286(34):29635-43. Zhang Y, Bonzo JA, Gonzalez FJ, Wang L. PMID: 21725089; PMCID: PMC3191004.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    210. Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology. 2011 Aug; 54(2):472-83. Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, Shah YM. PMID: 21538443; PMCID: PMC3145012.
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    211. Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα. Toxicol Lett. 2011 Sep 10; 205(3):265-72. Li Y, Ramdhan DH, Naito H, Yamagishi N, Ito Y, Hayashi Y, Yanagiba Y, Okamura A, Tamada H, Gonzalez FJ, Nakajima T. PMID: 21712084; PMCID: PMC6661110.
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    212. Pregnane X receptor- and CYP3A4-humanized mouse models and their applications. Br J Pharmacol. 2011 Jun; 163(3):461-8. Cheng J, Ma X, Gonzalez FJ. PMID: 21091656; PMCID: PMC3101609.
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    213. The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α. Hepatology. 2011 Jun; 53(6):2063-74. Santangelo L, Marchetti A, Cicchini C, Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T, Amicone L, Tripodi M. PMID: 21384409; PMCID: PMC6624426.
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    214. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes. 2011 Jul; 60(7):1861-71. Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, Dumont J, Bouchaert E, van Dijk TH, Lucas A, Dorchies E, Daoudi M, Lestavel S, Gonzalez FJ, Oresic M, Cariou B, Kuipers F, Caron S, Staels B. PMID: 21593203; PMCID: PMC3121443.
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    215. Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J Biol Chem. 2011 Jun 03; 286(22):19511-22. Patterson AD, Bonzo JA, Li F, Krausz KW, Eichler GS, Aslam S, Tigno X, Weinstein JN, Hansen BC, Idle JR, Gonzalez FJ. PMID: 21487016; PMCID: PMC3103330.
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    216. Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice. Hepatology. 2011 Apr; 53(4):1282-93. Matsubara T, Tanaka N, Patterson AD, Cho JY, Krausz KW, Gonzalez FJ. PMID: 21480330; PMCID: PMC3077083.
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    217. Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011 Jun; 140(7):2044-55. Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ, Shah YM. PMID: 21419768; PMCID: PMC3109109.
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    218. PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. J Nutr. 2011 Apr 01; 141(4):603-10. Abdelmegeed MA, Yoo SH, Henderson LE, Gonzalez FJ, Woodcroft KJ, Song BJ. PMID: 21346097; PMCID: PMC3056578.
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    219. A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol. 2011 Apr 15; 81(8):1043-53. Li F, Patterson AD, Höfer CC, Krausz KW, Gonzalez FJ, Idle JR. PMID: 21300029; PMCID: PMC6309239.
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    220. Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats. Radiat Res. 2011 Apr; 175(4):473-84. Johnson CH, Patterson AD, Krausz KW, Lanz C, Kang DW, Luecke H, Gonzalez FJ, Idle JR. PMID: 21309707; PMCID: PMC3089756.
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    221. Pregnane X receptor-mediated induction of Cyp3a by black cohosh. Xenobiotica. 2011 Feb; 41(2):112-23. Pang X, Cheng J, Krausz KW, Guo DA, Gonzalez FJ. PMID: 20979450; PMCID: PMC3019262.
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    222. Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo. Mol Endocrinol. 2010 Dec; 24(12):2343-55. Bonzo JA, Patterson AD, Krausz KW, Gonzalez FJ. PMID: 20943816; PMCID: PMC2999475.
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    223. Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicol Sci. 2010 Dec; 118(2):380-90. Lu H, Gonzalez FJ, Klaassen C. PMID: 20935164; PMCID: PMC2984525.
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    224. PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells. Toxicol Sci. 2010 Dec; 118(2):404-10. Qu A, Shah YM, Matsubara T, Yang Q, Gonzalez FJ. PMID: 20813756; PMCID: PMC2984533.
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    225. Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model. Diabetes. 2010 Nov; 59(11):2916-27. Wang XX, Jiang T, Shen Y, Caldas Y, Miyazaki-Anzai S, Santamaria H, Urbanek C, Solis N, Scherzer P, Lewis L, Gonzalez FJ, Adorini L, Pruzanski M, Kopp JB, Verlander JW, Levi M. PMID: 20699418; PMCID: PMC2963551.
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    226. Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice. Biochem Pharmacol. 2010 Nov 15; 80(10):1601-12. Tanaka N, Zhang X, Sugiyama E, Kono H, Horiuchi A, Nakajima T, Kanbe H, Tanaka E, Gonzalez FJ, Aoyama T. PMID: 20691165; PMCID: PMC6338080.
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    227. High density lipoprotein turnover is dependent on peroxisome proliferator-activated receptor α in mice. J Atheroscler Thromb. 2010 Nov 27; 17(11):1149-59. Akita N, Tsujita M, Yokota T, Gonzalez FJ, Ohte N, Kimura G, Yokoyama S. PMID: 20668363.
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    228. Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. J Pharmacol Exp Ther. 2010 Oct; 335(1):32-41. Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ. PMID: 20627999; PMCID: PMC2957776.
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    229. Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol. 2010 Oct 01; 80(7):1063-74. Li F, Patterson AD, Höfer CC, Krausz KW, Gonzalez FJ, Idle JR. PMID: 20541539; PMCID: PMC2941803.
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    230. Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice. Lab Invest. 2010 Oct; 90(10):1457-67. Stroeve JH, Brufau G, Stellaard F, Gonzalez FJ, Staels B, Kuipers F. PMID: 20531290; PMCID: PMC6643294.
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    231. Xenobiotic metabolism: a view through the metabolometer. Chem Res Toxicol. 2010 May 17; 23(5):851-60. Patterson AD, Gonzalez FJ, Idle JR. PMID: 20232918; PMCID: PMC2872059.
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    232. The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. Mass Spectrom Rev. 2010 May-Jun; 29(3):503-21. Patterson AD, Lanz C, Gonzalez FJ, Idle JR. PMID: 19890938; PMCID: PMC3690279.
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    233. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology. 2010 Aug; 139(2):653-63. Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. PMID: 20303349; PMCID: PMC2910786.
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    234. Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor alpha and role of the hypothalamic-pituitary-adrenal axis. J Biol Chem. 2010 Mar 05; 285(10):7670-85. Wang T, Shah YM, Matsubara T, Zhen Y, Tanabe T, Nagano T, Fotso S, Krausz KW, Zabriskie TM, Idle JR, Gonzalez FJ. PMID: 20032461; PMCID: PMC2844213.
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    235. Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. J Biol Chem. 2010 Jan 29; 285(5):3035-43. Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA. PMID: 19996107; PMCID: PMC2823426.
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    236. Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism. Mol Cell Biol. 2010 Feb; 30(3):565-77. Martinez-Jimenez CP, Kyrmizi I, Cardot P, Gonzalez FJ, Talianidis I. PMID: 19933841; PMCID: PMC2812226.
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    237. Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge. J Lipid Res. 2010 May; 51(5):1063-74. Cho JY, Matsubara T, Kang DW, Ahn SH, Krausz KW, Idle JR, Luecke H, Gonzalez FJ. PMID: 19965603; PMCID: PMC2853433.
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    238. A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19197-202. Guettier JM, Gautam D, Scarselli M, Ruiz de Azua I, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J. PMID: 19858481; PMCID: PMC2767362.
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    239. Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol Cell Biol. 2009 Dec; 29(24):6391-400. Sekine H, Mimura J, Oshima M, Okawa H, Kanno J, Igarashi K, Gonzalez FJ, Ikuta T, Kawajiri K, Fujii-Kuriyama Y. PMID: 19822660; PMCID: PMC2786870.
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    240. Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium. Mol Cell Biol. 2009 Dec; 29(23):6294-308. Cattin AL, Le Beyec J, Barreau F, Saint-Just S, Houllier A, Gonzalez FJ, Robine S, Pinçon-Raymond M, Cardot P, Lacasa M, Ribeiro A. PMID: 19805521; PMCID: PMC2786690.
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    241. Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. Mol Carcinog. 2009 Oct; 48(10):942-52. Foreman JE, Sorg JM, McGinnis KS, Rigas B, Williams JL, Clapper ML, Gonzalez FJ, Peters JM. PMID: 19415698; PMCID: PMC2790141.
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    242. The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1587-96. Wang XX, Jiang T, Shen Y, Adorini L, Pruzanski M, Gonzalez FJ, Scherzer P, Lewis L, Miyazaki-Anzai S, Levi M. PMID: 19776172; PMCID: PMC2801344.
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    243. The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene. Carcinogenesis. 2009 Nov; 30(11):1957-61. Shi S, Yoon DY, Hodge-Bell KC, Bebenek IG, Whitekus MJ, Zhang R, Cochran AJ, Huerta-Yepez S, Yim SH, Gonzalez FJ, Jaiswal AK, Hankinson O. PMID: 19755658; PMCID: PMC2791324.
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    244. Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis. Toxicol Sci. 2010 Jan; 113(1):27-36. Bility MT, Zhu B, Kang BH, Gonzalez FJ, Peters JM. PMID: 19748995; PMCID: PMC2794329.
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    245. Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation. J Proteome Res. 2009 Sep; 8(9):4293-300. Patterson AD, Slanar O, Krausz KW, Li F, Höfer CC, Perlík F, Gonzalez FJ, Idle JR. PMID: 19569716; PMCID: PMC2760252.
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    246. Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem Pharmacol. 2010 Jan 01; 79(1):57-66. Abdelmegeed MA, Moon KH, Chen C, Gonzalez FJ, Song BJ. PMID: 19660437; PMCID: PMC2784150.
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    247. Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress. Free Radic Biol Med. 2009 Sep 15; 47(6):767-78. Abdelmegeed MA, Moon KH, Hardwick JP, Gonzalez FJ, Song BJ. PMID: 19539749; PMCID: PMC2759705.
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    248. Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor. Toxicol Sci. 2009 Sep; 111(1):19-26. Yanagiba Y, Ito Y, Kamijima M, Gonzalez FJ, Nakajima T. PMID: 19525444.
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    249. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos. 2009 Aug; 37(8):1611-21. Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ. PMID: 19460945; PMCID: PMC2712435.
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    250. Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. PLoS One. 2009; 4(5):e5489. Li L, Oropeza CE, Sainz B, Uprichard SL, Gonzalez FJ, McLachlan A. PMID: 19424486; PMCID: PMC2674568.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    251. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009 May; 9(5):428-39. Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. PMID: 19416713; PMCID: PMC2803070.
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    252. Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha. Toxicol Sci. 2009 Jul; 110(1):204-11. Foreman JE, Chang SC, Ehresman DJ, Butenhoff JL, Anderson CR, Palkar PS, Kang BH, Gonzalez FJ, Peters JM. PMID: 19359353.
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    253. Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress. J Hepatol. 2009 Jun; 50(6):1236-46. Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez FJ, Aoyama T. PMID: 19398233; PMCID: PMC2809859.
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    254. Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chem Res Toxicol. 2009 Apr; 22(4):699-707. Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ. PMID: 19256530; PMCID: PMC2670930.
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    255. Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. Biol Pharm Bull. 2009 Feb; 32(2):172-8. Nomoto M, Miyata M, Yin S, Kurata Y, Shimada M, Yoshinari K, Gonzalez FJ, Suzuki K, Shibasaki S, Kurosawa T, Yamazoe Y. PMID: 19182371; PMCID: PMC2829856.
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    256. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab. 2009 Feb; 9(2):152-64. Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ. PMID: 19147412; PMCID: PMC2659630.
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    257. Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation. J Lipid Res. 2009 May; 50(5):924-37. Cho JY, Kang DW, Ma X, Ahn SH, Krausz KW, Luecke H, Idle JR, Gonzalez FJ. PMID: 19141872; PMCID: PMC2666179.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    258. Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1. Cell Metab. 2008 Dec; 8(6):482-91. Wang N, Yang G, Jia Z, Zhang H, Aoyagi T, Soodvilai S, Symons JD, Schnermann JB, Gonzalez FJ, Litwin SE, Yang T. PMID: 19041764; PMCID: PMC5484540.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    259. PPAR{alpha} attenuates the proinflammatory response in activated mesangial cells. Am J Physiol Renal Physiol. 2009 Feb; 296(2):F328-36. Kono K, Kamijo Y, Hora K, Takahashi K, Higuchi M, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T. PMID: 19036849.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    260. Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption. Drug Metab Dispos. 2009 Feb; 37(2):338-44. Miyata M, Matsuda Y, Nomoto M, Takamatsu Y, Sato N, Hamatsu M, Dawson PA, Gonzalez FJ, Yamazoe Y. PMID: 18988759; PMCID: PMC2680521.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    261. Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J Pharmacol Exp Ther. 2009 Feb; 328(2):469-77. Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, Pinson D, Gao X, Zhang Y, Ganapathy V, Gonzalez FJ, Guo GL. PMID: 18981289; PMCID: PMC2682273.
      View in: PubMed   Mentions: 117     Fields:    Translation:Animals
    262. Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor. J Toxicol Sci. 2008 Oct; 33(4):405-13. Minami K, Nakajima M, Fujiki Y, Katoh M, Gonzalez FJ, Yokoi T. PMID: 18827440; PMCID: PMC7217312.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    263. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug Metab Dispos. 2008 Dec; 36(12):2506-12. Ma X, Cheung C, Krausz KW, Shah YM, Wang T, Idle JR, Gonzalez FJ. PMID: 18799805; PMCID: PMC2678901.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    264. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. J Pharmacol Exp Ther. 2008 Nov; 327(2):288-99. Cheung C, Gonzalez FJ. PMID: 18682571; PMCID: PMC2597361.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    265. Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci. 2008 Oct; 105(2):418-28. Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM. PMID: 18622026; PMCID: PMC2527639.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    266. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis. 2008 Jul; 14(7):908-20. Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y. PMID: 18338782; PMCID: PMC2435391.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    267. The pregnane X receptor: from bench to bedside. Expert Opin Drug Metab Toxicol. 2008 Jul; 4(7):895-908. Ma X, Idle JR, Gonzalez FJ. PMID: 18624678; PMCID: PMC2535920.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    268. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab. 2008 Apr; 7(4):302-11. Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, Gonzalez FJ. PMID: 18396136; PMCID: PMC2587176.
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    269. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology. 2008 Jun; 134(7):2036-48, 2048.e1-3. Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ. PMID: 18439915; PMCID: PMC2533811.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    270. Effects of fibrate drugs on expression of ABCA1 and HDL biogenesis in hepatocytes. J Cardiovasc Pharmacol. 2008 Mar; 51(3):258-66. Hossain MA, Tsujita M, Gonzalez FJ, Yokoyama S. PMID: 18356690.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    271. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab. 2008 Feb; 7(2):135-47. Chen C, Shah YM, Morimura K, Krausz KW, Miyazaki M, Richardson TA, Morgan ET, Ntambi JM, Idle JR, Gonzalez FJ. PMID: 18249173; PMCID: PMC2276699.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    272. Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver. Toxicol Appl Pharmacol. 2008 May 15; 229(1):10-9. Sato S, Shirakawa H, Tomita S, Ohsaki Y, Haketa K, Tooi O, Santo N, Tohkin M, Furukawa Y, Gonzalez FJ, Komai M. PMID: 18295293.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    273. A metabolomic perspective of melatonin metabolism in the mouse. Endocrinology. 2008 Apr; 149(4):1869-79. Ma X, Chen C, Krausz KW, Idle JR, Gonzalez FJ. PMID: 18187545; PMCID: PMC2276702.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    274. UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem. 2008 Feb 01; 80(3):665-74. Patterson AD, Li H, Eichler GS, Krausz KW, Weinstein JN, Fornace AJ, Gonzalez FJ, Idle JR. PMID: 18173289; PMCID: PMC2254319.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    275. Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice. J Occup Health. 2008; 50(2):169-80. Takashima K, Ito Y, Gonzalez FJ, Nakajima T. PMID: 18403868; PMCID: PMC7217336.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    276. Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. J Biol Chem. 2008 Feb 22; 283(8):4543-59. Chen C, Krausz KW, Idle JR, Gonzalez FJ. PMID: 18093979; PMCID: PMC2268247.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    277. PPARalpha protects proximal tubular cells from acute fatty acid toxicity. J Am Soc Nephrol. 2007 Dec; 18(12):3089-100. Kamijo Y, Hora K, Kono K, Takahashi K, Higuchi M, Ehara T, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T. PMID: 17978304.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    278. Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance. J Pharmacol Exp Ther. 2008 Feb; 324(2):674-84. Wang T, Ma X, Krausz KW, Idle JR, Gonzalez FJ. PMID: 17962516; PMCID: PMC2268525.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    279. PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology. 2008 Apr 03; 246(1):2-8. Gonzalez FJ, Shah YM. PMID: 18006136.
      View in: PubMed   Mentions: 113     Fields:    Translation:Animals
    280. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res. 2007 Dec; 48(12):2664-72. Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, Kliewer SA, Gonzalez FJ. PMID: 17720959.
      View in: PubMed   Mentions: 275     Fields:    Translation:Animals
    281. CCAAT/enhancer-binding protein delta (C/EBPdelta) maintains amelogenin expression in the absence of C/EBPalpha in vivo. J Biol Chem. 2007 Oct 12; 282(41):29882-9. Xu Y, Zhou YL, Gonzalez FJ, Snead ML. PMID: 17704518; PMCID: PMC4445686.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    282. The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. Toxicol Sci. 2008 Jan; 101(1):132-9. Yang Q, Nagano T, Shah Y, Cheung C, Ito S, Gonzalez FJ. PMID: 17690133; PMCID: PMC2197159.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    283. Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. J Clin Invest. 2007 Jul; 117(7):1940-50. Ito S, Chen C, Satoh J, Yim S, Gonzalez FJ. PMID: 17607366; PMCID: PMC1890999.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    284. Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. Mol Endocrinol. 2007 Sep; 21(9):2136-51. Zhen Y, Krausz KW, Chen C, Idle JR, Gonzalez FJ. PMID: 17550978; PMCID: PMC2084472.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    285. Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR. Toxicology. 2007 Sep 05; 238(2-3):147-56. Lee CH, Ito Y, Yanagiba Y, Yamanoshita O, Kim H, Zhang SY, Kamijima M, Gonzalez FJ, Nakajima T. PMID: 17618724.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    286. Animal models for human risk assessment: the peroxisome proliferator-activated receptor alpha-humanized mouse. Nutr Rev. 2007 Jun; 65(6 Pt 2):S2-6. Gonzalez FJ. PMID: 17605307.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    287. Glucocorticoid signaling synchronizes the liver circadian transcriptome. Hepatology. 2007 Jun; 45(6):1478-88. Reddy AB, Maywood ES, Karp NA, King VM, Inoue Y, Gonzalez FJ, Lilley KS, Kyriacou CP, Hastings MH. PMID: 17538967.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    288. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007 Jun; 117(6):1658-69. Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. PMID: 17525798; PMCID: PMC1868788.
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    289. The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. J Lipid Res. 2007 Aug; 48(8):1781-91. Dongol B, Shah Y, Kim I, Gonzalez FJ, Hunt MC. PMID: 17485727.
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    290. Rifaximin is a gut-specific human pregnane X receptor activator. J Pharmacol Exp Ther. 2007 Jul; 322(1):391-8. Ma X, Shah YM, Guo GL, Wang T, Krausz KW, Idle JR, Gonzalez FJ. PMID: 17442842.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    291. Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol Cell Biol. 2007 Jun; 27(12):4238-47. Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez FJ. PMID: 17438130; PMCID: PMC1900062.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    292. A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1297-304. Ichihara S, Yamada Y, Ichihara G, Nakajima T, Li P, Kondo T, Gonzalez FJ, Murohara T. PMID: 17413038.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    293. Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site. J Mol Biol. 2007 Jun 08; 369(3):640-52. Arpiainen S, Lämsä V, Pelkonen O, Yim SH, Gonzalez FJ, Hakkola J. PMID: 17466327.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    294. Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice. Drug Metab Dispos. 2007 Jul; 35(7):1223-31. Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF. PMID: 17392391.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    295. Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. Carcinogenesis. 2007 Jun; 28(6):1171-7. Yang Q, Ito S, Gonzalez FJ. PMID: 17331954; PMCID: PMC1885989.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    296. A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach. Chem Res Toxicol. 2007 Mar; 20(3):531-42. Chen C, Ma X, Malfatti MA, Krausz KW, Kimura S, Felton JS, Idle JR, Gonzalez FJ. PMID: 17279779; PMCID: PMC1850849.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    297. LC-MS-based metabolomics in drug metabolism. Drug Metab Rev. 2007; 39(2-3):581-97. Chen C, Gonzalez FJ, Idle JR. PMID: 17786640; PMCID: PMC2140249.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimals
    298. CYP3A4 and pregnane X receptor humanized mice. J Biochem Mol Toxicol. 2007; 21(4):158-62. Gonzalez FJ. PMID: 17936928.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    299. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis. 2007 May; 28(5):940-6. Kim I, Morimura K, Shah Y, Yang Q, Ward JM, Gonzalez FJ. PMID: 17183066; PMCID: PMC1858639.
      View in: PubMed   Mentions: 168     Fields:    Translation:Animals
    300. Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. Am J Physiol Gastrointest Liver Physiol. 2007 Apr; 292(4):G1114-22. Shah YM, Ma X, Morimura K, Kim I, Gonzalez FJ. PMID: 17170021.
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    301. Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. Am J Physiol Gastrointest Liver Physiol. 2007 Feb; 292(2):G657-66. Shah YM, Morimura K, Gonzalez FJ. PMID: 17095756; PMCID: PMC1796914.
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    302. The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metab Dispos. 2007 Feb; 35(2):194-200. Ma X, Shah Y, Cheung C, Guo GL, Feigenbaum L, Krausz KW, Idle JR, Gonzalez FJ. PMID: 17093002.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    303. The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases. Biochem Pharmacol. 2007 Feb 15; 73(4):561-73. Giri S, Krausz KW, Idle JR, Gonzalez FJ. PMID: 17123469.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    304. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 2007 Mar; 28(3):732-7. Ma X, Idle JR, Malfatti MA, Krausz KW, Nebert DW, Chen CS, Felton JS, Waxman DJ, Gonzalez FJ. PMID: 17052995; PMCID: PMC1829392.
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    305. Effects of FXR in foam-cell formation and atherosclerosis development. Biochim Biophys Acta. 2006 Dec; 1761(12):1401-9. Guo GL, Santamarina-Fojo S, Akiyama TE, Amar MJ, Paigen BJ, Brewer B, Gonzalez FJ. PMID: 17110163; PMCID: PMC1751860.
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    306. Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane. Drug Metab Dispos. 2007 Jan; 35(1):95-102. Medina-Díaz IM, Arteaga-Illán G, de León MB, Cisneros B, Sierra-Santoyo A, Vega L, Gonzalez FJ, Elizondo G. PMID: 17035600.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    307. The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. Drug Metab Dispos. 2007 Jan; 35(1):1-8. Gonzalez FJ. PMID: 17020953.
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    308. Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX. Cancer Res. 2006 Oct 01; 66(19):9656-64. Meng LH, Shankavaram U, Chen C, Agama K, Fu HQ, Gonzalez FJ, Weinstein J, Pommier Y. PMID: 17018623.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    309. Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia. Biochem Biophys Res Commun. 2006 Nov 17; 350(2):370-6. Sugiyama E, Tanaka N, Nakajima T, Kamijo Y, Yokoyama S, Li Y, Gonzalez FJ, Aoyama T. PMID: 17011521.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    310. Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha. J Lipid Res. 2006 Nov; 47(11):2503-14. Hanniman EA, Lambert G, Inoue Y, Gonzalez FJ, Sinal CJ. PMID: 16929032.
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    311. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 2006 Aug 15; 20(16):2293-305. Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez FJ, Talianidis I. PMID: 16912278; PMCID: PMC1553211.
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    312. Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR. Mol Cell Endocrinol. 2006 Aug 15; 256(1-2):23-33. Matsusue K, Miyoshi A, Yamano S, Gonzalez FJ. PMID: 16806672; PMCID: PMC1544360.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    313. Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase. Drug Metab Pharmacokinet. 2006 Aug; 21(4):315-23. Miyata M, Matsuda Y, Tsuchiya H, Kitada H, Akase T, Shimada M, Nagata K, Gonzalez FJ, Yamazoe Y. PMID: 16946559.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    314. Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice. Endocrinology. 2006 Oct; 147(10):4772-80. Yang Q, Kurotani R, Yamada A, Kimura S, Gonzalez FJ. PMID: 16857745; PMCID: PMC1570154.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    315. Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. J Biol Chem. 2006 Sep 08; 281(36):26540-51. Ding X, Lichti K, Kim I, Gonzalez FJ, Staudinger JL. PMID: 16825189; PMCID: PMC2991045.
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    316. Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha. Mol Pharmacol. 2006 Oct; 70(4):1281-90. Shin M, Kim I, Inoue Y, Kimura S, Gonzalez FJ. PMID: 16807375.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    317. 3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio. Drug Metab Dispos. 2006 Sep; 34(9):1563-74. Zhen Y, Slanar O, Krausz KW, Chen C, Slavík J, McPhail KL, Zabriskie TM, Perlík F, Gonzalez FJ, Idle JR. PMID: 16782768; PMCID: PMC1553181.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    318. Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone). J Pharmacol Exp Ther. 2006 Sep; 318(3):1330-42. Chen C, Meng L, Ma X, Krausz KW, Pommier Y, Idle JR, Gonzalez FJ. PMID: 16775196; PMCID: PMC1551906.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    319. A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. Chem Res Toxicol. 2006 Jun; 19(6):818-27. Giri S, Idle JR, Chen C, Zabriskie TM, Krausz KW, Gonzalez FJ. PMID: 16780361; PMCID: PMC1482804.
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    320. Urinary metabolites and antioxidant products of exogenous melatonin in the mouse. J Pineal Res. 2006 May; 40(4):343-9. Ma X, Idle JR, Krausz KW, Tan DX, Ceraulo L, Gonzalez FJ. PMID: 16635022; PMCID: PMC1448215.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    321. Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J Biol Chem. 2006 Jun 16; 281(24):16625-31. Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M. PMID: 16606610.
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    322. Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stress. Biochem J. 2006 Mar 01; 394(Pt 2):e3-5. Gonzalez FJ. PMID: 16479620; PMCID: PMC1408685.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    323. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PMID: 16492734; PMCID: PMC1413918.
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    324. Alterations in skin and stratified epithelia by constitutively activated PPARalpha. J Invest Dermatol. 2006 Feb; 126(2):374-85. Yang Q, Yamada A, Kimura S, Peters JM, Gonzalez FJ. PMID: 16374467.
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    325. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem. 2006 Apr 21; 281(16):11039-49. Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, Abdelkarim M, Caron S, Torpier G, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B. PMID: 16446356.
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    326. Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol. 2006; 46:41-64. Gonzalez FJ, Yu AM. PMID: 16402898; PMCID: PMC1440291.
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    327. Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression. J Mol Med (Berl). 2006 Apr; 84(4):334-44. Inoue Y, Peters LL, Yim SH, Inoue J, Gonzalez FJ. PMID: 16389552.
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    328. Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis. Carcinogenesis. 2006 May; 27(5):1074-80. Morimura K, Cheung C, Ward JM, Reddy JK, Gonzalez FJ. PMID: 16377806; PMCID: PMC1447533.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    329. The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab. 2005 Dec; 2(6):373-84. Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K. PMID: 16330323.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    330. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther. 2006 Mar; 316(3):1328-34. Cheung C, Yu AM, Chen CS, Krausz KW, Byrd LG, Feigenbaum L, Edwards RJ, Waxman DJ, Gonzalez FJ. PMID: 16291874.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    331. Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha. Biochem Biophys Res Commun. 2006 Jan 06; 339(1):196-203. Lee H, Gonzalez FJ, Yoon M. PMID: 16297877.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    332. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. J Lipid Res. 2006 Jan; 47(1):215-27. Inoue Y, Yu AM, Yim SH, Ma X, Krausz KW, Inoue J, Xiang CC, Brownstein MJ, Eggertsen G, Björkhem I, Gonzalez FJ. PMID: 16264197; PMCID: PMC1413576.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    333. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res. 2006 Jan; 47(1):201-14. Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA. PMID: 16251721.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    334. Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G1016-24. Bosse T, van Wering HM, Gielen M, Dowling LN, Fialkovich JJ, Piaseckyj CM, Gonzalez FJ, Akiyama TE, Montgomery RK, Grand RJ, Krasinski SD. PMID: 16223943.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    335. Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2. Chem Res Toxicol. 2005 Sep; 18(9):1471-8. Cheung C, Ma X, Krausz KW, Kimura S, Feigenbaum L, Dalton TP, Nebert DW, Idle JR, Gonzalez FJ. PMID: 16167840.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    336. Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12531-6. Jia Y, Guo GL, Surapureddi S, Sarkar J, Qi C, Guo D, Xia J, Kashireddi P, Yu S, Cho YW, Rao MS, Kemper B, Ge K, Gonzalez FJ, Reddy JK. PMID: 16109766; PMCID: PMC1187948.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    337. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005 Aug 12; 122(3):337-49. Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. PMID: 16096055.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansAnimalsCells
    338. Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett. 2005 Aug 01; 579(19):4076-80. Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk T, Grefhorst A, Bouchaert E, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B. PMID: 16023103.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    339. Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9406-11. Zhang H, Zhang A, Kohan DE, Nelson RD, Gonzalez FJ, Yang T. PMID: 15956187; PMCID: PMC1166599.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    340. The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. J Biol Chem. 2005 Aug 19; 280(33):29971-9. Duran-Sandoval D, Cariou B, Percevault F, Hennuyer N, Grefhorst A, van Dijk TH, Gonzalez FJ, Fruchart JC, Kuipers F, Staels B. PMID: 15899888.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    341. Potential role for human cytochrome P450 3A4 in estradiol homeostasis. Endocrinology. 2005 Jul; 146(7):2911-9. Yu AM, Fukamachi K, Krausz KW, Cheung C, Gonzalez FJ. PMID: 15817670.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    342. PPARgamma in endothelial cells influences high fat diet-induced hypertension. Am J Hypertens. 2005 Apr; 18(4 Pt 1):549-56. Nicol CJ, Adachi M, Akiyama TE, Gonzalez FJ. PMID: 15831367.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    343. Getting fat: two new players in molecular adipogenesis. Cell Metab. 2005 Feb; 1(2):85-6. Gonzalez FJ. PMID: 16054047.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    344. Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):585-91. Duez H, Lefebvre B, Poulain P, Torra IP, Percevault F, Luc G, Peters JM, Gonzalez FJ, Gineste R, Helleboid S, Dzavik V, Fruchart JC, Fiévet C, Lefebvre P, Staels B. PMID: 15618549.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCTClinical Trials
    345. Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr; 33(4):489-94. Ma X, Idle JR, Krausz KW, Gonzalez FJ. PMID: 15616152.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    346. Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett. 2004 Dec 03; 578(1-2):63-8. Kamiya A, Inoue Y, Kodama T, Gonzalez FJ. PMID: 15581617.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    347. The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metab Dispos. 2005 Mar; 33(3):449-57. Cheung C, Yu AM, Ward JM, Krausz KW, Akiyama TE, Feigenbaum L, Gonzalez FJ. PMID: 15576447.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    348. Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice. Biochem Pharmacol. 2004 Dec 01; 68(11):2143-50. Yang Q, Gonzalez FJ. PMID: 15498504.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    349. Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice. Toxicol Pathol. 2004 Nov-Dec; 32(6):710-8. Ward JM, Nikolov NP, Tschetter JR, Kopp JB, Gonzalez FJ, Kimura S, Siegel RM. PMID: 15580705.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    350. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology. 2004 Oct; 40(4):972-80. Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T. PMID: 15382117.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    351. Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity. J Pharmacol Exp Ther. 2005 Feb; 312(2):759-66. Miyata M, Tozawa A, Otsuka H, Nakamura T, Nagata K, Gonzalez FJ, Yamazoe Y. PMID: 15466244.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    352. Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol Sci. 2004 Dec; 82(2):374-80. Guo GL, Moffit JS, Nicol CJ, Ward JM, Aleksunes LA, Slitt AL, Kliewer SA, Manautou JE, Gonzalez FJ. PMID: 15456926.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    353. Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis. 2005 Jan; 26(1):219-27. Hays T, Rusyn I, Burns AM, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM. PMID: 15447978.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    354. TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices. Hepatology. 2004 Sep; 40(3):527-36. Kamiya A, Gonzalez FJ. PMID: 15349890.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    355. Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice. Mol Endocrinol. 2004 Nov; 18(11):2751-64. Matsusue K, Gavrilova O, Lambert G, Brewer HB, Ward JM, Inoue Y, LeRoith D, Gonzalez FJ. PMID: 15319454.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    356. Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis. J Biol Chem. 2004 Oct 22; 279(43):44740-8. Inoue Y, Inoue J, Lambert G, Yim SH, Gonzalez FJ. PMID: 15292250.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    357. Regulation of drug transporters by the farnesoid X receptor in mice. Mol Pharm. 2004 Jul-Aug; 1(4):281-9. Maeda T, Miyata M, Yotsumoto T, Kobayashi D, Nozawa T, Toyama K, Gonzalez FJ, Yamazoe Y, Tamai I. PMID: 15981587.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    358. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. J Biol Chem. 2004 Aug 13; 279(33):35017-24. Miyazaki M, Dobrzyn A, Sampath H, Lee SH, Man WC, Chu K, Peters JM, Gonzalez FJ, Ntambi JM. PMID: 15180999.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    359. The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Endocrinology. 2004 Sep; 145(9):4268-77. Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F. PMID: 15178647.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    360. Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha. Cancer Res. 2004 Jun 01; 64(11):3849-54. Cheung C, Akiyama TE, Ward JM, Nicol CJ, Feigenbaum L, Vinson C, Gonzalez FJ. PMID: 15172993.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    361. Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab Rev. 2004 May; 36(2):243-77. Yu AM, Idle JR, Gonzalez FJ. PMID: 15237854.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    362. PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis. Carcinogenesis. 2004 Sep; 25(9):1747-55. Nicol CJ, Yoon M, Ward JM, Yamashita M, Fukamachi K, Peters JM, Gonzalez FJ. PMID: 15073042.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    363. Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem. 2004 Jun 04; 279(23):24427-34. Jia Y, Qi C, Kashireddi P, Surapureddi S, Zhu YJ, Rao MS, Le Roith D, Chambon P, Gonzalez FJ, Reddy JK. PMID: 15150259.
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    364. Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. Nat Med. 2004 May; 10(5):481-3. Harman FS, Nicol CJ, Marin HE, Ward JM, Gonzalez FJ, Peters JM. PMID: 15048110.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
    365. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem. 2004 Jun 04; 279(23):23847-50. Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. PMID: 15028720.
      View in: PubMed   Mentions: 327     Fields:    Translation:HumansAnimalsCells
    366. Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet. J Biol Chem. 2004 May 14; 279(20):20874-81. Akiyama TE, Lambert G, Nicol CJ, Matsusue K, Peters JM, Brewer HB, Gonzalez FJ. PMID: 15001574.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    367. Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice. FEBS Lett. 2004 Jan 30; 558(1-3):96-100. Nukaya M, Takahashi Y, Gonzalez FJ, Kamataki T. PMID: 14759523.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    368. Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Mol Endocrinol. 2004 Apr; 18(4):851-62. Zhang Y, Repa JJ, Inoue Y, Hayhurst GP, Gonzalez FJ, Mangelsdorf DJ. PMID: 14715930.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    369. Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion. Hepatology. 2004 Jan; 39(1):157-66. Andreola F, Calvisi DF, Elizondo G, Jakowlew SB, Mariano J, Gonzalez FJ, De Luca LM. PMID: 14752834.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    370. Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice. J Biol Chem. 2004 Jan 30; 279(5):3434-8. Andreola F, Hayhurst GP, Luo G, Ferguson SS, Gonzalez FJ, Goldstein JA, De Luca LM. PMID: 14623888.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    371. Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice. Biochem Pharmacol. 2003 Nov 15; 66(10):2011-20. Cheung C, Akiyama TE, Kudo G, Gonzalez FJ. PMID: 14599559.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    372. Role of gene knockout and transgenic mice in the study of xenobiotic metabolism. Drug Metab Rev. 2003 Nov; 35(4):319-35. Gonzalez FJ. PMID: 14705864.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    373. Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation. J Lipid Res. 2004 Feb; 45(2):244-52. Jiang YJ, Lu B, Xu FY, Gartshore J, Taylor WA, Halayko AJ, Gonzalez FJ, Takasaki J, Choy PC, Hatch GM. PMID: 14594999.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    374. Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation. J Biol Chem. 2004 Jan 23; 279(4):2480-9. Inoue Y, Yu AM, Inoue J, Gonzalez FJ. PMID: 14583614.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    375. T cell-specific disruption of arylhydrocarbon receptor nuclear translocator (Arnt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution. J Immunol. 2003 Oct 15; 171(8):4113-20. Tomita S, Jiang HB, Ueno T, Takagi S, Tohi K, Maekawa S, Miyatake A, Furukawa A, Gonzalez FJ, Takeda J, Ichikawa Y, Takahama Y. PMID: 14530333.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    376. Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J Hepatol. 2003 Oct; 39(4):480-8. Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, Gonzalez FJ, Marschall HU, Zatloukal K, Denk H, Trauner M. PMID: 12971955.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    377. Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol. 2003 Oct; 23(19):6739-49. Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, Gonzalez FJ, Takahama Y. PMID: 12972594; PMCID: PMC193947.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    378. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol. 2003 Oct; 23(20):7222-9. Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. PMID: 14517292; PMCID: PMC230305.
      View in: PubMed   Mentions: 70     Fields:    Translation:Animals
    379. Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology. 2003 Sep; 125(3):825-38. Wagner M, Fickert P, Zollner G, Fuchsbichler A, Silbert D, Tsybrovskyy O, Zatloukal K, Guo GL, Schuetz JD, Gonzalez FJ, Marschall HU, Denk H, Trauner M. PMID: 12949728.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    380. Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem. 2003 Nov 14; 278(46):45062-71. Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB, Kliewer SA, Gonzalez FJ, Sinal CJ. PMID: 12923173.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    381. Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology. 2003 Aug; 125(2):544-55. Claudel T, Inoue Y, Barbier O, Duran-Sandoval D, Kosykh V, Fruchart J, Fruchart JC, Gonzalez FJ, Staels B. PMID: 12891557.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    382. Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones. Drug Metab Dispos. 2003 Jul; 31(7):924-31. Hu M, Krausz K, Chen J, Ge X, Li J, Gelboin HL, Gonzalez FJ. PMID: 12814970.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    383. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem. 2003 Sep 05; 278(36):34268-76. Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML. PMID: 12805374.
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    384. Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice. Biochim Biophys Acta. 2003 Jun 10; 1632(1-3):80-9. Peters JM, Aoyama T, Burns AM, Gonzalez FJ. PMID: 12782154.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    385. Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology. 2003 Jun; 37(6):1375-84. Kamiya A, Inoue Y, Gonzalez FJ. PMID: 12774017.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    386. Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics. 2003 Jun; 13(6):307-19. Yu AM, Idle JR, Herraiz T, Küpfer A, Gonzalez FJ. PMID: 12777961.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    387. In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha. FEBS Lett. 2003 May 22; 543(1-3):120-4. Tanaka N, Hora K, Makishima H, Kamijo Y, Kiyosawa K, Gonzalez FJ, Aoyama T. PMID: 12753917.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    388. Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. Drug Metab Dispos. 2003 May; 31(5):548-58. Granvil CP, Yu AM, Elizondo G, Akiyama TE, Cheung C, Feigenbaum L, Krausz KW, Gonzalez FJ. PMID: 12695342.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    389. Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine. J Pharmacol Exp Ther. 2003 Apr; 305(1):315-22. Yu AM, Idle JR, Krausz KW, Küpfer A, Gonzalez FJ. PMID: 12649384.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    390. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4012-7. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM. PMID: 12651943; PMCID: PMC153039.
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    391. Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. J Biol Chem. 2003 May 16; 278(20):17838-44. Kitada H, Miyata M, Nakamura T, Tozawa A, Honma W, Shimada M, Nagata K, Sinal CJ, Guo GL, Gonzalez FJ, Yamazoe Y. PMID: 12637555.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    392. Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. Pharmacogenetics. 2003 Mar; 13(3):173-81. Yu AM, Idle JR, Byrd LG, Krausz KW, Küpfer A, Gonzalez FJ. PMID: 12618595.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    393. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest. 2003 Mar; 111(5):737-47. Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B, Reitman ML, Gonzalez FJ. PMID: 12618528; PMCID: PMC151902.
      View in: PubMed   Mentions: 247     Fields:    Translation:Animals
    394. Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2. Carcinogenesis. 2003 Mar; 24(3):583-7. Kimura S, Kawabe M, Yu A, Morishima H, Fernandez-Salguero P, Hammons GJ, Ward JM, Kadlubar FF, Gonzalez FJ. PMID: 12663521.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    395. Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochim Biophys Acta. 2003 Feb 17; 1619(3):223-34. Akiyama TE, Gonzalez FJ. PMID: 12573481.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    396. The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine. J Pharmacol Exp Ther. 2003 Feb; 304(2):539-46. Yu AM, Granvil CP, Haining RL, Krausz KW, Corchero J, Küpfer A, Idle JR, Gonzalez FJ. PMID: 12538805.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    397. Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle. Lab Invest. 2003 Feb; 83(2):259-69. Nöhammer C, Brunner F, Wölkart G, Staber PB, Steyrer E, Gonzalez FJ, Zechner R, Hoefler G. PMID: 12594240.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    398. Transgenic models in xenobiotic metabolism and toxicology. Toxicology. 2002 Dec 27; 181-182:237-9. Gonzalez FJ. PMID: 12505317.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    399. Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C1090-9. Guo H, Wei J, Inoue Y, Gonzalez FJ, Kuo PC. PMID: 12466152.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    400. Positive regulation of connexin32 transcription by hepatocyte nuclear factor-1alpha. Arch Biochem Biophys. 2002 Nov 15; 407(2):160-7. Koffler LD, Fernstrom MJ, Akiyama TE, Gonzalez FJ, Ruch RJ. PMID: 12413486.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    401. The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis. Mol Cell Endocrinol. 2002 Jul 31; 193(1-2):71-9. Gonzalez FJ. PMID: 12161004.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    402. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). J Biol Chem. 2002 Oct 11; 277(41):37991-8000. Louet JF, Hayhurst G, Gonzalez FJ, Girard J, Decaux JF. PMID: 12107181.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    403. Identification of functions of peroxisome proliferator-activated receptor alpha in proximal tubules. J Am Soc Nephrol. 2002 Jul; 13(7):1691-702. Kamijo Y, Hora K, Tanaka N, Usuda N, Kiyosawa K, Nakajima T, Gonzalez FJ, Aoyama T. PMID: 12089364.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    404. 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. J Pharmacol Exp Ther. 2002 Jun; 301(3):1025-32. Granvil CP, Krausz KW, Gelboin HV, Idle JR, Gonzalez FJ. PMID: 12023534.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    405. Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo. J Biol Chem. 2002 Jul 12; 277(28):25257-65. Inoue Y, Hayhurst GP, Inoue J, Mori M, Gonzalez FJ. PMID: 11994307.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    406. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002 May 31; 296(5573):1703-6. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. PMID: 11988537.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    407. Selective intranuclear redistribution of PPAR isoforms by RXR alpha. Mol Endocrinol. 2002 Apr; 16(4):707-21. Akiyama TE, Baumann CT, Sakai S, Hager GL, Gonzalez FJ. PMID: 11923467.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    408. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002 Apr; 22(8):2607-19. Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee YH, Ricote M, Glass CK, Brewer HB, Gonzalez FJ. PMID: 11909955; PMCID: PMC133709.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    409. Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem. 2002 May 17; 277(20):17830-5. Cui Y, Miyoshi K, Claudio E, Siebenlist UK, Gonzalez FJ, Flaws J, Wagner KU, Hennighausen L. PMID: 11884400.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    410. The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility. Genesis. 2002 Mar; 32(3):231-9. Le Provost F, Riedlinger G, Hee Yim S, Benedict J, Gonzalez FJ, Flaws J, Hennighausen L. PMID: 11892012.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    411. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 2002 Jan 01; 16(1):22-6. Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM. PMID: 11782441; PMCID: PMC155311.
      View in: PubMed   Mentions: 537     Fields:    Translation:AnimalsCells
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