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Frank Gonzalez

Title(s)Assistant Professor of Clinical Pediatrics
SchoolKeck School of Medicine of Usc
Address4650 Sunset Blvd.
Off Campus
Los Angeles CA 90027
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity. Pharmacol Res. 2025 Oct; 220:107942. Nie L, Yan N, Gonzalez FJ, Hao H, Yan T. PMID: 40907676.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells. Acta Pharmacol Sin. 2025 Sep 02. Yu XT, Zhao N, Ma YT, Jia JM, Song YT, Liu XY, Xiao Y, Jia B, Li GM, He JH, Wang S, Zhu JM, Gonzalez FJ, Qu AJ. PMID: 40897853.
      View in: PubMed   Mentions:    Fields:    
    3. Human PXR Signaling Exacerbates Ethanol-induced Liver Injury in Females: Evidence From Mouse Models and Human Alcohol-associated Liver Disease Cohorts. Cell Mol Gastroenterol Hepatol. 2025 Jul 16; 19(11):101589. Ofosu-Boateng M, Choi S, Kim S, Twum E, Nnamani DO, Gebreyesus LH, Niture S, Yadak N, Kumar D, Gonzalez FJ, Liangpunsakul S, Cui JY, Gyamfi MA. PMID: 40681042; PMCID: PMC12478072.
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    4. Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression. Cell Metab. 2025 Sep 02; 37(9):1852-1869.e8. Qu R, Zhang Y, Kim B, Zeng G, Wang P, Shaoyong W, Huang Y, Guo W, Chen Y, Wang P, Yang Q, Lu S, Zhou X, Weng J, Xu J, Lin J, Wang K, Ma Y, Takahashi S, Luo Y, Yu X, Krausz KW, Pang Y, Hong T, Zhang Z, Fu W, Gonzalez FJ, Sun L. PMID: 40609532; PMCID: PMC12365777.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Blockade of the estrogen receptor alpha-pregnane X receptor axis protects ovariectomized mice against ethanol-induced hepatotoxicity. J Biol Chem. 2025 Jun; 301(6):110238. Twum E, Ofosu-Boateng M, Nnamani DO, Gebreyesus LH, Yadak N, Kharbanda KK, Gonzalez FJ, Gyamfi MA. PMID: 40381698; PMCID: PMC12182306.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate. Toxicol Sci. 2025 May 01; 205(1):47-52. Khan Y, Schmidt AM, Oldro KJ, Zhu X, Kramer AR, Hamilton SR, Bleil KO, Krisko RM, Zitzow JD, Tian Y, Chang SC, Walter V, Cohen SM, Gonzalez FJ, Patterson AD, Peters JM. PMID: 40036302; PMCID: PMC12225666.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Erratum: Publisher erratum to "Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway" [Acta Pharmaceutica Sinica B 14 (2024) 2992-3008]. Acta Pharm Sin B. 2025 Jun; 15(6):3354. Fan S, Gao Y, Zhao P, Xie G, Zhou Y, Yang X, Li X, Zhang S, Gonzalez FJ, Qu A, Huang M, Bi H. PMID: 40654370; PMCID: PMC12254756.
      View in: PubMed   Mentions:
    8. Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling. Science. 2025 Apr 04; 388(6742):eadt0548. Yang Y, Hao C, Jiao T, Yang Z, Li H, Zhang Y, Zhang W, Doherty M, Sun C, Yang T, Li J, Wu J, Zhang M, Wang Y, Xie D, Wang T, Wang N, Huang X, Li C, Gonzalez FJ, Wei J, Xie C, Zeng C, Lei G. PMID: 40179178.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Farnesoid X receptor regulates CYP1A1 and CYP1B1 and estradiol metabolism in mouse and human cell lines. Chem Biol Interact. 2025 May 01; 412:111471. Chen C, Lin P, Wu Z, Lin Y, Huang M, He L, Yao X, Gonzalez FJ, Qin Z, Yao Z. PMID: 40064219.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism. Cell Metab. 2025 May 06; 37(5):1119-1136.e13. Jiang J, Gao Y, Wang J, Huang Y, Yang R, Zhang Y, Ma Y, Wen Y, Luo G, Zhang S, Cao Y, Yu M, Wang Q, Hu S, Wang K, Guo X, Gonzalez FJ, Liu Y, Liu H, Xie Q, Xie C. PMID: 40015281.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects. HGG Adv. 2025 Apr 10; 6(2):100411. Downie CG, Shrestha P, Okello S, Yaser M, Lee HH, Wang Y, Krishnan M, Chen HH, Justice AE, Chittoor G, Josyula NS, Gahagan S, Blanco E, Burrows R, Correa-Burrows P, Albala C, Santos JL, Angel B, Lozoff B, Hartwig FP, Horta B, Brina KR, Isasi CR, Qi Q, Gallo LC, Perreira KM, Thyagarajan B, Daviglus M, Van Horn L, Gonzalez F, Bradfield JP, Hakonarson H, Grant SFA, Below JE, Felix J, Graff M, Divaris K, North KE. PMID: 39885687; PMCID: PMC11875162.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. The association of physical activity fragmentation with all-cause mortality in Hispanics: a prospective cohort study. Lancet Reg Health Am. 2025 Feb; 42:100996. Mediano MFF, Mok Y, Ballew SH, Gonzalez F, Sotres-Alvarez D, Mossavar-Rahmani Y, Kaplan R, Carlson JA, Alver SK, Daviglus M, Garcia-Bedoya O, Evenson KR, Schrack JA, Matsushita K. PMID: 39925467; PMCID: PMC11804820.
      View in: PubMed   Mentions: 1  
    13. Associations of chronic liver disease and liver cancer with glyphosate and its metabolites in Thailand. Int J Cancer. 2025 May 15; 156(10):1885-1897. Patel DP, Loffredo CA, Pupacdi B, Rabibhadana S, Navasumrit P, Chaisaingmongkol J, Toulabi L, Haznadar M, Dalal B, Khan M, Stone J, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Budhu A, Mahidol C, Wang XW, Gonzalez FJ, Ruchirawat M, Harris CC, TIGER-LC Consortium. PMID: 39653658; PMCID: PMC11924304.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders. Acta Pharm Sin B. 2025 Feb; 15(2):892-908. Xia Y, Zhang Y, Zhang Z, Yan N, Sawaswong V, Sun L, Guo W, Wang P, Krausz KW, Gavrilova O, Ntambi JM, Hao H, Yan T, Gonzalez FJ. PMID: 40177566; PMCID: PMC11959918.
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    15. Adipose triglyceride lipase as a target for treatment of metabolic dysfunction-associated steatohepatitis: The role of hepatic and intestinal PPARα. J Hepatol. 2025 Apr; 82(4):556-559. Gonzalez FJ, Xia Y. PMID: 39542137.
      View in: PubMed   Mentions: 1     Fields:    
    16. E2F3a activates Gadd45b gene expression through PPARα-mediated transcriptional regulation in hepatic cells. Mol Cells. 2024 Dec; 47(12):100148. Woo MS, Khalil AAK, Gonzalez FJ, Kim JH. PMID: 39537030; PMCID: PMC11647606.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Hepatocyte-specific SLC27A4 deletion ameliorates nonalcoholic fatty liver disease in mice via suppression of phosphatidylcholine-mediated PXR activation. Metabolism. 2025 Jan; 162:156054. Shen C, Pan Z, Xie W, Zhao J, Miao D, Zhao L, Liu M, Zhong Y, Zhong C, Gonzalez FJ, Wang W, Gao Y, Liu C. PMID: 39489412.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose. Sci Transl Med. 2024 09 25; 16(766):eadk8446. Tung HC, Kim JW, Zhu J, Li S, Yan J, Liu Q, Koo I, Koshkin SA, Hao F, Zhong G, Xu M, Wang Z, Wang J, Huang Y, Xi Y, Cai X, Xu P, Ren S, Higashiyama T, Gonzalez FJ, Li S, Isoherranen N, Yang D, Ma X, Patterson AD, Xie W. PMID: 39321267; PMCID: PMC12084873.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Understanding Enterohepatic Bile Acid Pools and Their Impact on Intestinal Physiology. Cell Mol Gastroenterol Hepatol. 2024; 18(6):101400. Takahashi S, Gonzalez FJ. PMID: 39326854; PMCID: PMC11607537.
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    20. Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation. Adv Sci (Weinh). 2024 Oct; 11(40):e2400794. Yokoyama S, Koo I, Aibara D, Tian Y, Murray IA, Collins SL, Coslo DM, Kono M, Peters JM, Proia RL, Gonzalez FJ, Perdew GH, Patterson AD. PMID: 39207053; PMCID: PMC11516111.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    21. Urinary Metabolite Diagnostic and Prognostic Liquid Biopsy Biomarkers of Lung Cancer in Nonsmokers and Tobacco Smokers. Clin Cancer Res. 2024 Aug 15; 30(16):3592-3602. Dalal B, Tada T, Patel DP, Pine SR, Khan M, Oike T, Kanke Y, Parker AL, Haznadar M, Toulabi L, Krausz KW, Robles AI, Bowman ED, Gonzalez FJ, Harris CC. PMID: 38837903; PMCID: PMC11325153.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Human CYP2D6 varies across the estrous cycle in brains of transgenic mice altering drug response. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Dec 20; 135:111108. Miksys S, McDonald C, Baghai Wadji F, Gonzalez FJ, Tyndale RF. PMID: 39069248; PMCID: PMC11402587.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    23. Superoxide is an Intrinsic Signaling Molecule Triggering Muscle Hypertrophy. Antioxid Redox Signal. 2025 Jan; 42(1-3):1-15. Lu S, Zhou Y, Liu M, Gong L, Liu L, Duan Z, Chen K, Gonzalez FJ, Wei F, Xiang R, Li G. PMID: 38877802; PMCID: PMC11807898.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis. Acta Pharmacol Sin. 2024 Nov; 45(11):2313-2327. Wen YQ, Zou ZY, Zhao GG, Zhang MJ, Zhang YX, Wang GH, Shi JJ, Wang YY, Song YY, Wang HX, Chen RY, Zheng DX, Duan XQ, Liu YM, Gonzalez FJ, Fan JG, Xie C. PMID: 38992119; PMCID: PMC11489735.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. Molecular targets of PXR-dependent ethanol-induced hepatotoxicity in female mice. Biochem Pharmacol. 2024 10; 228:116416. Choi S, Ofosu-Boateng M, Kim S, Nnamani DO, Mah'moud M, Neequaye P, Gebreyesus LH, Twum E, Gonzalez FJ, Yue Cui J, Gyamfi MA. PMID: 38986717; PMCID: PMC11410527.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids. Biomolecules. 2024 May 21; 14(6). Zhu B, Zhu X, Borland MG, Ralph DH, Chiaro CR, Krausz KW, Ntambi JM, Glick AB, Patterson AD, Perdew GH, Gonzalez FJ, Peters JM. PMID: 38927010; PMCID: PMC11201440.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. Changes in the type 2 diabetes gut mycobiome associate with metformin treatment across populations. mBio. 2024 Jun 12; 15(6):e0016924. Van Syoc E, Nixon MP, Silverman JD, Luo Y, Gonzalez FJ, Elbere I, Klovins J, Patterson AD, Rogers CJ, Ganda E. PMID: 38767350; PMCID: PMC11237675.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    28. CBFA2T3 Is PPARA Sensitive and Attenuates Fasting-Induced Lipid Accumulation in Mouse Liver. Cells. 2024 05 13; 13(10). Kim D, Ha SK, Gonzalez FJ. PMID: 38786053; PMCID: PMC11119203.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression. J Clin Invest. 2024 Apr 01; 134(7). Yan T, Yan N, Xia Y, Sawaswong V, Zhu X, Dias HB, Aibara D, Takahashi S, Hamada K, Saito Y, Li G, Liu H, Yan H, Velenosi TJ, Krausz KW, Huang J, Kimura S, Rotman Y, Qu A, Hao H, Gonzalez FJ. PMID: 38557493; PMCID: PMC10977981.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    30. Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway. Acta Pharm Sin B. 2024 Jul; 14(7):2992-3008. Fan S, Gao Y, Zhao P, Xie G, Zhou Y, Yang X, Li X, Zhang S, Gonzalez FJ, Qu A, Huang M, Bi H. PMID: 39027236; PMCID: PMC11252459.
      View in: PubMed   Mentions: 5  
    31. Intermittent fasting shifts the diurnal transcriptome atlas of transcription factors. Mol Cell Biochem. 2025 Jan; 480(1):491-504. Fu M, Lu S, Gong L, Zhou Y, Wei F, Duan Z, Xiang R, Gonzalez FJ, Li G. PMID: 38528297.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    32. Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine. Int J Biol Sci. 2024; 20(6):2187-2201. Bao L, Fu L, Su Y, Chen Z, Peng Z, Sun L, Gonzalez FJ, Wu C, Zhang H, Shi B, Shi YB. PMID: 38617535; PMCID: PMC11008275.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    33. Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet. Biomed Pharmacother. 2024 Apr; 173:116341. Gebreyesus LH, Choi S, Neequaye P, Mahmoud M, Mahmoud M, Ofosu-Boateng M, Twum E, Nnamani DO, Wang L, Yadak N, Ghosh S, Gonzalez FJ, Gyamfi MA. PMID: 38428309; PMCID: PMC10983615.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    34. Bile salt hydrolase catalyses formation of amine-conjugated bile acids. Nature. 2024 Feb; 626(8000):859-863. Rimal B, Collins SL, Tanes CE, Rocha ER, Granda MA, Solanki S, Hoque NJ, Gentry EC, Koo I, Reilly ER, Hao F, Paudel D, Singh V, Yan T, Kim MS, Bittinger K, Zackular JP, Krausz KW, Desai D, Amin S, Coleman JP, Shah YM, Bisanz JE, Gonzalez FJ, Vanden Heuvel JP, Wu GD, Zemel BS, Dorrestein PC, Weinert EE, Patterson AD. PMID: 38326609; PMCID: PMC10881385.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    35. HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements. Commun Biol. 2024 01 31; 7(1):144. Thakur A, Park K, Cullum R, Fuglerud BM, Khoshnoodi M, Drissler S, Stephan TL, Lotto J, Kim D, Gonzalez FJ, Hoodless PA. PMID: 38297077; PMCID: PMC10830483.
      View in: PubMed   Mentions: 2  Translation:AnimalsCells
    36. A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage. Cell Host Microbe. 2024 Feb 14; 32(2):191-208.e9. Li T, Ding N, Guo H, Hua R, Lin Z, Tian H, Yu Y, Fan D, Yuan Z, Gonzalez FJ, Wu Y. PMID: 38237593; PMCID: PMC10922796.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    37. Estrogen genotoxicity causes preferential development of Fuchs endothelial corneal dystrophy in females. Redox Biol. 2024 02; 69:102986. Kumar V, Deshpande N, Parekh M, Wong R, Ashraf S, Zahid M, Hui H, Miall A, Kimpton S, Price MO, Price FW, Gonzalez FJ, Rogan E, Jurkunas UV. PMID: 38091879; PMCID: PMC10716776.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    38. Reverse metabolomics for the discovery of chemical structures from humans. Nature. 2024 Feb; 626(7998):419-426. Gentry EC, Collins SL, Panitchpakdi M, Belda-Ferre P, Stewart AK, Carrillo Terrazas M, Lu HH, Zuffa S, Yan T, Avila-Pacheco J, Plichta DR, Aron AT, Wang M, Jarmusch AK, Hao F, Syrkin-Nikolau M, Vlamakis H, Ananthakrishnan AN, Boland BS, Hemperly A, Vande Casteele N, Gonzalez FJ, Clish CB, Xavier RJ, Chu H, Baker ES, Patterson AD, Knight R, Siegel D, Dorrestein PC. PMID: 38052229; PMCID: PMC10849969.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    39. Changes in the Type 2 diabetes gut mycobiome associate with metformin treatment across populations. bioRxiv. 2023 Nov 03. Van Syoc E, Nixon MP, Silverman JD, Luo Y, Gonzalez FJ, Elbere I, Klovins J, Patterson AD, Rogers CJ, Ganda E. PMID: 37398234; PMCID: PMC10312434.
      View in: PubMed   Mentions:
    40. Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney. Am J Pathol. 2023 12; 193(12):1969-1987. Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, Bhasin K, Shults N, Qi Y, Krausz KW, Zerfas PM, Takahashi S, Daneshpajouhnejad P, Titievsky A, Taranenko E, Billon C, Chatterjee A, Elgendy B, Walker JK, Albanese C, Kopp JB, Rosenberg AZ, Gonzalez FJ, Guha U, Brodsky L, Burris TP, Levi M. PMID: 37717940; PMCID: PMC10734281.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    41. Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii. Phytomedicine. 2023 Dec; 121:155054. Dai M, Peng W, Lin L, Wu ZE, Zhang T, Zhao Q, Cheng Y, Lin Q, Zhang B, Liu A, Rao Q, Huang J, Zhao J, Gonzalez FJ, Li F. PMID: 37738906.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    42. Oleuropein Promotes Neural Plasticity and Neuroprotection via PPARα-Dependent and Independent Pathways. Biomedicines. 2023 Aug 11; 11(8). Malliou F, Andriopoulou CE, Kofinas A, Katsogridaki A, Leondaritis G, Gonzalez FJ, Michaelidis TM, Darsinou M, Skaltsounis LA, Konstandi M. PMID: 37626746; PMCID: PMC10452728.
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    43. Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice. Metabolites. 2023 Aug 10; 13(8). Zhu X, Liu Q, Patterson AD, Sharma AK, Amin SG, Cohen SM, Gonzalez FJ, Peters JM. PMID: 37623879; PMCID: PMC10456914.
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    44. Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science. 2023 08 04; 381(6657):eadd5787. Wang K, Zhang Z, Hang J, Liu J, Guo F, Ding Y, Li M, Nie Q, Lin J, Zhuo Y, Sun L, Luo X, Zhong Q, Ye C, Yun C, Zhang Y, Wang J, Bao R, Pang Y, Wang G, Gonzalez FJ, Lei X, Qiao J, Jiang C. PMID: 37535747.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    45. Farnesoid X receptor activation inhibits pancreatic carcinogenesis. Biochim Biophys Acta Mol Basis Dis. 2023 10; 1869(7):166811. Xu Z, Huang Z, Zhang Y, Sun H, Hinz U, Heger U, Loos M, Gonzalez FJ, Hackert T, Bergmann F, Fortunato F. PMID: 37515840; PMCID: PMC10935600.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    46. AKAP12 promotes cancer stem cell-like phenotypes and activates STAT3 in colorectal cancer. Clin Transl Oncol. 2023 Nov; 25(11):3263-3276. Li K, Wu X, Li Y, Hu TT, Wang W, Gonzalez FJ, Liu W. PMID: 37326825.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    47. Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function. Acta Pharmacol Sin. 2023 Nov; 44(11):2184-2200. Zhu XX, Wang X, Jiao SY, Liu Y, Shi L, Xu Q, Wang JJ, Chen YE, Zhang Q, Song YT, Wei M, Yu BQ, Fielitz J, Gonzalez FJ, Du J, Qu AJ. PMID: 37328648; PMCID: PMC10618178.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    48. Interactions between the host dietary habits and the gut microbiota influence weight management. Life Med. 2023 Jun; 2(3):lnad020. Gao Y, Lin J, Gonzalez FJ, Jiang C. PMID: 39872295; PMCID: PMC11749338.
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    49. The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11. Front Immunol. 2023; 14:1178355. Tolbert WD, Chen Y, Sun L, Benlarbi M, Ding S, Manickam R, Pangaro E, Nguyen DN, Gottumukkala S, Côté M, Gonzalez FJ, Finzi A, Tehrani ZR, Sajadi MM, Pazgier M. PMID: 37334379; PMCID: PMC10272436.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    50. Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice. Hepatol Commun. 2023 06 01; 7(6). Golonka RM, Yeoh BS, Saha P, Gohara A, Tummala R, Stepkowski S, Tiwari AK, Joe B, Gonzalez FJ, Gewirtz AT, Vijay-Kumar M. PMID: 37219858; PMCID: PMC10208708.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    51. Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (RARβ) Gene in Hepatocytes. Int J Mol Sci. 2023 May 11; 24(10). Zolfaghari R, Bonzo JA, Gonzalez FJ, Ross AC. PMID: 37239961; PMCID: PMC10218549.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    52. PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice. J Biochem. 2023 Apr 26; 173(5):393-411. Kasano-Camones CI, Takizawa M, Ohshima N, Saito C, Iwasaki W, Nakagawa Y, Fujitani Y, Yoshida R, Saito Y, Izumi T, Terawaki SI, Sakaguchi M, Gonzalez FJ, Inoue Y. PMID: 36779417; PMCID: PMC10433406.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    53. Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence. Int J Biol Sci. 2023; 19(7):2067-2080. Chen P, Tian J, Zhou Y, Chen Y, Zhang H, Jiao T, Huang M, Zhang H, Huang P, Yu AM, Gonzalez FJ, Bi H. PMID: 37151873; PMCID: PMC10158022.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    54. Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice. Nat Commun. 2023 04 01; 14(1):1829. Zhao Q, Dai MY, Huang RY, Duan JY, Zhang T, Bao WM, Zhang JY, Gui SQ, Xia SM, Dai CT, Tang YM, Gonzalez FJ, Li F. PMID: 37005411; PMCID: PMC10067939.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    55. Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs. ACS Pharmacol Transl Sci. 2023 Mar 10; 6(3):422-446. Park JE, Lee H, Oliva P, Kirsch K, Kim B, Ahn JI, Alverez CN, Gaikwad S, Krausz KW, O'Connor R, Rai G, Simeonov A, Mock BA, Gonzalez FJ, Lee KS, Jacobson KA. PMID: 36926457; PMCID: PMC10012257.
      View in: PubMed   Mentions: 1  
    56. Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nat Commun. 2023 02 10; 14(1):755. Sun L, Zhang Y, Cai J, Rimal B, Rocha ER, Coleman JP, Zhang C, Nichols RG, Luo Y, Kim B, Chen Y, Krausz KW, Harris CC, Patterson AD, Zhang Z, Takahashi S, Gonzalez FJ. PMID: 36765047; PMCID: PMC9918522.
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    57. Keratin 79 is a PPARA target that is highly expressed by liver damage. Biochem Biophys Res Commun. 2023 04 02; 650:132-136. Kim D, Choi I, Ha SK, Gonzalez FJ. PMID: 36796223; PMCID: PMC10681120.
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    58. Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. Hepatology. 2023 11 01; 78(5):1625-1653. Gong L, Wei F, Gonzalez FJ, Li G. PMID: 36626642; PMCID: PMC10681123.
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    59. Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer. Cell Metab. 2023 01 03; 35(1):134-149.e6. Bell HN, Huber AK, Singhal R, Korimerla N, Rebernick RJ, Kumar R, El-Derany MO, Sajjakulnukit P, Das NK, Kerk SA, Solanki S, James JG, Kim D, Zhang L, Chen B, Mehra R, Frankel TL, Gyorffy B, Fearon ER, Pasca di Magliano M, Gonzalez FJ, Banerjee R, Wahl DR, Lyssiotis CA, Green M, Shah YM. PMID: 36528023; PMCID: PMC9841369.
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    60. Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins. Nat Commun. 2022 11 26; 13(1):7303. Nanduri R, Furusawa T, Lobanov A, He B, Xie C, Dadkhah K, Kelly MC, Gavrilova O, Gonzalez FJ, Bustin M. PMID: 36435799; PMCID: PMC9701217.
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    61. Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting. Cell Rep. 2022 10 25; 41(4):111547. Wei F, Gong L, Lu S, Zhou Y, Liu L, Duan Z, Xiang R, Gonzalez FJ, Li G. PMID: 36288692; PMCID: PMC9671760.
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    62. Gut bacteria alleviate smoking-related NASH by degrading gut nicotine. Nature. 2022 10; 610(7932):562-568. Chen B, Sun L, Zeng G, Shen Z, Wang K, Yin L, Xu F, Wang P, Ding Y, Nie Q, Wu Q, Zhang Z, Xia J, Lin J, Luo Y, Cai J, Krausz KW, Zheng R, Xue Y, Zheng MH, Li Y, Yu C, Gonzalez FJ, Jiang C. PMID: 36261549; PMCID: PMC9589931.
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    63. The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice. J Biol Chem. 2022 11; 298(11):102530. Wang XX, Xie C, Libby AE, Ranjit S, Levi J, Myakala K, Bhasin K, Jones BA, Orlicky DJ, Takahashi S, Dvornikov A, Kleiner DE, Hewitt SM, Adorini L, Kopp JB, Krausz KW, Rosenberg A, McManaman JL, Robertson CE, Ir D, Frank DN, Luo Y, Gonzalez FJ, Gratton E, Levi M. PMID: 36209823; PMCID: PMC9638804.
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    64. Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer. NPJ Precis Oncol. 2022 Oct 07; 6(1):70. Velenosi TJ, Krausz KW, Hamada K, Dorsey TH, Ambs S, Takahashi S, Gonzalez FJ. PMID: 36207498; PMCID: PMC9547066.
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    65. Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor-ceramide axis and ameliorates NASH in mice. Hepatol Commun. 2022 12; 6(12):3363-3378. Jiang J, Ma Y, Liu Y, Lu D, Gao X, Krausz KW, Desai D, Amin SG, Patterson AD, Gonzalez FJ, Xie C. PMID: 36196594; PMCID: PMC9701488.
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    66. Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule. J Steroid Biochem Mol Biol. 2023 01; 225:106182. He L, Chen C, Duan S, Li Y, Li C, Yao X, Gonzalez FJ, Qin Z, Yao Z. PMID: 36152789.
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    67. Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal. Cell Stem Cell. 2022 09 01; 29(9):1366-1381.e9. Chen L, Jiao T, Liu W, Luo Y, Wang J, Guo X, Tong X, Lin Z, Sun C, Wang K, He Y, Zhang Y, Xu H, Wang J, Zuo J, Ding Q, He S, Gonzalez FJ, Xie C. PMID: 36055192; PMCID: PMC10673678.
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    68. Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver. Mol Cell Endocrinol. 2022 11 01; 557:111722. Kim D, Kim B, Brocker CN, Karri K, Waxman DJ, Gonzalez FJ. PMID: 35917881; PMCID: PMC9561029.
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    69. Creatine riboside is a cancer cell-derived metabolite associated with arginine auxotrophy. J Clin Invest. 2022 07 15; 132(14). Parker AL, Toulabi L, Oike T, Kanke Y, Patel D, Tada T, Taylor S, Beck JA, Bowman E, Reyzer ML, Butcher D, Kuhn S, Pauly GT, Krausz KW, Gonzalez FJ, Hussain SP, Ambs S, Ryan BM, Wang XW, Harris CC. PMID: 35838048; PMCID: PMC9282934.
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    70. Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities. Sci Adv. 2022 Jul 15; 8(28):eabn4188. Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. PMID: 35857504; PMCID: PMC9278865.
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    71. Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity. Acta Pharmacol Sin. 2023 Jan; 44(1):145-156. Zhong XC, Liu YM, Gao XX, Krausz KW, Niu B, Gonzalez FJ, Xie C. PMID: 35655096; PMCID: PMC9813015.
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    72. Critical role of peroxisome proliferator-activated receptor α in promoting platelet hyperreactivity and thrombosis under hyperlipidemia. Haematologica. 2022 06 01; 107(6):1358-1373. Li L, Zhou J, Wang S, Jiang L, Chen X, Zhou Y, Li J, Shi J, Liu P, Shu Z, Gonzalez FJ, Liu A, Hu H. PMID: 34615341; PMCID: PMC9152986.
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    73. Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. Hepatology. 2023 01 01; 77(1):239-255. Yan T, Luo Y, Yan N, Hamada K, Zhao N, Xia Y, Wang P, Zhao C, Qi D, Yang S, Sun L, Cai J, Wang Q, Jiang C, Gavrilova O, Krausz KW, Patel DP, Yu X, Wu X, Hao H, Liu W, Qu A, Gonzalez FJ. PMID: 35460276; PMCID: PMC9970020.
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    74. HNF4A modulates glucocorticoid action in the liver. Cell Rep. 2022 04 19; 39(3):110697. Hunter AL, Poolman TM, Kim D, Gonzalez FJ, Bechtold DA, Loudon ASI, Iqbal M, Ray DW. PMID: 35443180; PMCID: PMC9380254.
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    75. Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation. iScience. 2022 May 20; 25(5):104196. Aibara D, Takahashi S, Yagai T, Kim D, Brocker CN, Levi M, Matsusue K, Gonzalez FJ. PMID: 35479397; PMCID: PMC9036120.
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    76. Epigenome-Wide Analysis of DNA Methylation in Parkinson's Disease Cortex. Life (Basel). 2022 Mar 29; 12(4). Kaut O, Schmitt I, Stahl F, Fröhlich H, Hoffmann P, Gonzalez FJ, Wüllner U. PMID: 35454993; PMCID: PMC9025601.
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    77. Postprandial Plasma Lipidomics Reveal Specific Alteration of Hepatic-derived Diacylglycerols in Nonalcoholic Fatty Liver Disease. Gastroenterology. 2022 06; 162(7):1990-2003. Velenosi TJ, Ben-Yakov G, Podszun MC, Hercun J, Etzion O, Yang S, Nadal C, Haynes-Williams V, Huang WA, González-Hódar L, Brychta RJ, Takahashi S, Akkaraju V, Krausz KW, Walter M, Cai H, Walter PJ, Muniyappa R, Chen KY, Gonzalez FJ, Rotman Y. PMID: 35283114; PMCID: PMC9117487.
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    78. Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis. Cell Host Microbe. 2022 03 09; 30(3):289-300. Cai J, Sun L, Gonzalez FJ. PMID: 35271802; PMCID: PMC8923532.
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    79. Disruption of peroxisome proliferator-activated receptor α in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway. Int J Biol Sci. 2022; 18(6):2317-2328. Zhang Z, Yao T, Zhao N, Liu H, Cheng H, Gonzalez FJ, Wang H, Wang G, Qu A, Wang Y. PMID: 35414769; PMCID: PMC8990472.
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    80. Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity. Acta Pharm Sin B. 2022 May; 12(5):2224-2238. Zhang Y, Yan T, Wang T, Liu X, Hamada K, Sun D, Sun Y, Yang Y, Wang J, Takahashi S, Wang Q, Krausz KW, Jiang C, Xie C, Yang X, Gonzalez FJ. PMID: 35646522; PMCID: PMC9136617.
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    81. Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity. Hepatology. 2022 08; 76(2):387-403. Xiong H, Zhang C, Han L, Xu T, Saeed K, Han J, Liu J, Klaassen CD, Gonzalez FJ, Lu Y, Zhang Y. PMID: 34870866.
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    82. Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis. Food Chem Toxicol. 2022 Feb; 160:112807. Hamada K, Wang P, Xia Y, Yan N, Takahashi S, Krausz KW, Hao H, Yan T, Gonzalez FJ. PMID: 34995708; PMCID: PMC10353774.
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    83. YAP-TEAD mediates PPAR α-induced hepatomegaly and liver regeneration in mice. Hepatology. 2022 01; 75(1):74-88. Fan S, Gao Y, Qu A, Jiang Y, Li H, Xie G, Yao X, Yang X, Zhu S, Yagai T, Tian J, Wang R, Gonzalez FJ, Huang M, Bi H. PMID: 34387904; PMCID: PMC10259205.
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    84. Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights. Drug Metab Dispos. 2022 05; 50(5):685-693. Xia Y, Yan M, Wang P, Hamada K, Yan N, Hao H, Gonzalez FJ, Yan T. PMID: 34903587; PMCID: PMC9132099.
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    85. The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice. Toxicology. 2022 01 15; 465:153056. Su S, Billy LJ, Chang S, Gonzalez FJ, Patterson AD, Peters JM. PMID: 34861291; PMCID: PMC10292111.
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    86. Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Feb; 1867(2):159089. Lu D, Liu Y, Luo Y, Zhao J, Feng C, Xue L, Xu J, Wang Q, Yan T, Xiao P, Krausz KW, Gonzalez FJ, Xie C. PMID: 34856412; PMCID: PMC8864892.
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    87. Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities. bioRxiv. 2021 Nov 24. Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. PMID: 34845451; PMCID: PMC8629194.
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    88. Polyamine metabolism links gut microbiota and testicular dysfunction. Microbiome. 2021 11 11; 9(1):224. Zhao Q, Huang JF, Cheng Y, Dai MY, Zhu WF, Yang XW, Gonzalez FJ, Li F. PMID: 34758869; PMCID: PMC8582214.
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    89. St. John's Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism. FASEB J. 2021 11; 35(11):e21968. Yan T, Luo Y, Xia Y, Hamada K, Wang Q, Yan N, Krausz KW, Ward JM, Hao H, Wang P, Gonzalez FJ. PMID: 34644426; PMCID: PMC10167919.
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    90. 2-Methoxyestradiol Ameliorates Angiotensin II-Induced Hypertension by Inhibiting Cytosolic Phospholipase A2α Activity in Female Mice. Hypertension. 2021 11; 78(5):1368-1381. Song CY, Singh P, Motiwala M, Shin JS, Lew J, Dutta SR, Gonzalez FJ, Bonventre JV, Malik KU. PMID: 34628937; PMCID: PMC8516072.
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    91. Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice. Toxicol Sci. 2021 08 30; 183(1):70-80. Foreman JE, Koga T, Kosyk O, Kang BH, Zhu X, Cohen SM, Billy LJ, Sharma AK, Amin S, Gonzalez FJ, Rusyn I, Peters JM. PMID: 34081128; PMCID: PMC8502481.
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    92. Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice. Toxicol Sci. 2021 08 30; 183(1):81-92. Foreman JE, Koga T, Kosyk O, Kang BH, Zhu X, Cohen SM, Billy LJ, Sharma AK, Amin S, Gonzalez FJ, Rusyn I, Peters JM. PMID: 34081146; PMCID: PMC8404993.
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    93. 6β-Hydroxytestosterone Promotes Angiotensin II-Induced Hypertension via Enhanced Cytosolic Phospholipase A2α Activity. Hypertension. 2021 09; 78(4):1053-1066. Singh P, Song CY, Dutta SR, Pingili A, Shin JS, Gonzalez FJ, Bonventre JV, Malik KU. PMID: 34420370; PMCID: PMC8415516.
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    94. Cardiomyocyte peroxisome proliferator-activated receptor α is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling. Acta Pharmacol Sin. 2022 May; 43(5):1231-1242. Wang X, Zhu XX, Jiao SY, Qi D, Yu BQ, Xie GM, Liu Y, Song YT, Xu Q, Xu QB, Gonzalez FJ, Du J, Wang XM, Qu AJ. PMID: 34376812; PMCID: PMC9061810.
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    95. Feedback repression of PPARα signaling by Let-7 microRNA. Cell Rep. 2021 08 10; 36(6):109506. Yagai T, Yan T, Luo Y, Takahashi S, Aibara D, Kim D, Brocker CN, Levi M, Motohashi H, Gonzalez FJ. PMID: 34380035; PMCID: PMC8424520.
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    96. Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity. Xenobiotica. 2021 Sep; 51(9):1047-1059. Sun D, Gao X, Wang Q, Krausz KW, Fang Z, Zhang Y, Xie C, Gonzalez FJ. PMID: 34319859; PMCID: PMC9491014.
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    97. Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells. Biochem Biophys Rep. 2021 Sep; 27:101091. Duan Y, Qi D, Liu Y, Song Y, Wang X, Jiao S, Li H, Gonzalez FJ, Qi Y, Xu Q, Du J, Qu A. PMID: 34381883; PMCID: PMC8339143.
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    98. Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL. Cancer Res. 2021 10 01; 81(19):5033-5046. Goldberg L, Negi V, Chung YJ, Onozawa M, Zhu YJ, Walker RL, Pierce R, Patel DP, Krausz KW, Gonzalez FJ, Goodell MA, Rodriguez BAT, Meltzer PS, Aplan PD. PMID: 34321240; PMCID: PMC8487989.
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    99. Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature. Biochem Pharmacol. 2021 11; 193:114698. Kim S, Choi S, Dutta M, Asubonteng JO, Polunas M, Goedken M, Gonzalez FJ, Cui JY, Gyamfi MA. PMID: 34303710; PMCID: PMC9135326.
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    100. Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. Hepatology. 2021 10; 74(4):1932-1951. Luo Y, Gao Y, Liu W, Yang Y, Jiang J, Wang Y, Tang W, Yang S, Sun L, Cai J, Guo X, Takahashi S, Krausz KW, Qu A, Chen L, Xie C, Gonzalez FJ. PMID: 33896016; PMCID: PMC9942701.
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    101. Intestinal MYC modulates obesity-related metabolic dysfunction. Nat Metab. 2021 07; 3(7):923-939. Luo Y, Yang S, Wu X, Takahashi S, Sun L, Cai J, Krausz KW, Guo X, Dias HB, Gavrilova O, Xie C, Jiang C, Liu W, Gonzalez FJ. PMID: 34211180; PMCID: PMC9944847.
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    102. Oleuropein-Induced Acceleration of Cytochrome P450-Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor α. Drug Metab Dispos. 2021 09; 49(9):833-843. Malliou F, Andriopoulou CE, Gonzalez FJ, Kofinas A, Skaltsounis AL, Konstandi M. PMID: 34162688; PMCID: PMC11022892.
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    103. Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus. Front Cell Dev Biol. 2021; 9:691801. Nguyen T, Zheng M, Knapp M, Sladojevic N, Zhang Q, Ai L, Harrison D, Chen A, Sitikov A, Shen L, Gonzalez FJ, Zhao Q, Fang Y, Liao JJK, Wu R. PMID: 34179020; PMCID: PMC8222825.
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    104. FXR-Deoxycholic Acid-TNF-α Axis Modulates Acetaminophen-Induced Hepatotoxicity. Toxicol Sci. 2021 05 27; 181(2):273-284. Yan T, Yan N, Wang H, Yagai T, Luo Y, Takahashi S, Zhao M, Krausz KW, Wang G, Hao H, Gonzalez FJ. PMID: 33662127; PMCID: PMC8163055.
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    105. Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling. Nat Commun. 2021 05 12; 12(1):2745. Geiger SS, Traba J, Richoz N, Farley TK, Brooks SR, Petermann F, Wang L, Gonzalez FJ, Sack MN, Siegel RM. PMID: 33980856; PMCID: PMC8115055.
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    106. Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. J Clin Invest. 2021 05 03; 131(9). Wu Q, Sun L, Hu X, Wang X, Xu F, Chen B, Liang X, Xia J, Wang P, Aibara D, Zhang S, Zeng G, Yun C, Yan Y, Zhu Y, Bustin M, Zhang S, Gonzalez FJ, Jiang C. PMID: 33938457; PMCID: PMC8087211.
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    107. Manassantin B attenuates obesity by inhibiting adipogenesis and lipogenesis in an AMPK dependent manner. FASEB J. 2021 05; 35(5):e21496. Cai J, Qiong G, Li C, Sun L, Luo Y, Yuan S, Gonzalez FJ, Xu J. PMID: 33904622; PMCID: PMC9813681.
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    108. Targeting Xenobiotic Nuclear Receptors PXR and CAR to Prevent Cobicistat Hepatotoxicity. Toxicol Sci. 2021 04 27; 181(1):58-67. Shehu AI, Zhu J, Li J, Lu J, McMahon D, Xie W, Gonzalez FJ, Ma X. PMID: 33629115; PMCID: PMC8081023.
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    109. The pathophysiological function of non-gastrointestinal farnesoid X receptor. Pharmacol Ther. 2021 10; 226:107867. Yan N, Yan T, Xia Y, Hao H, Wang G, Gonzalez FJ. PMID: 33895191.
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    110. Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver. Cell Mol Gastroenterol Hepatol. 2021; 12(2):585-597. Mooli RGR, Rodriguez J, Takahashi S, Solanki S, Gonzalez FJ, Ramakrishnan SK, Shah YM. PMID: 33798787; PMCID: PMC8258975.
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    111. Testosterone Metabolite 6β-Hydroxytestosterone Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysms in Apoe-/- Male Mice. J Am Heart Assoc. 2021 04 06; 10(7):e018536. Mukherjee K, Pingili AK, Singh P, Dhodi AN, Dutta SR, Gonzalez FJ, Malik KU. PMID: 33719500; PMCID: PMC8174379.
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    112. Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines. RSC Adv. 2021 Mar 05; 11(17):10385-10392. Zhao DF, Fan YF, Wang FY, Hou FB, Gonzalez FJ, Li SY, Wang P, Xia YL, Ge GB, Yang L. PMID: 35423513; PMCID: PMC8695704.
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    113. Novel Strategy for Mining and Identification of Acylcarnitines Using Data-Independent-Acquisition-Based Retention Time Prediction Modeling and Pseudo-Characteristic Fragmentation Ion Matching. J Proteome Res. 2021 03 05; 20(3):1602-1611. Feng C, Xue L, Lu D, Jin Y, Qiu X, Gonzalez FJ, Wang G, Zhou Z. PMID: 33625228.
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    114. Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell Death Dis. 2021 02 11; 12(2):174. Xia Y, Wang P, Yan N, Gonzalez FJ, Yan T. PMID: 33574236; PMCID: PMC7878893.
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    115. The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer. Nat Rev Gastroenterol Hepatol. 2021 05; 18(5):335-347. Sun L, Cai J, Gonzalez FJ. PMID: 33568795.
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    116. Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Nat Commun. 2021 01 12; 12(1):290. Kim JH, Matsubara T, Lee J, Fenollar-Ferrer C, Han K, Kim D, Jia S, Chang CJ, Yang H, Nagano T, Krausz KW, Yim SH, Gonzalez FJ. PMID: 33436590; PMCID: PMC7804329.
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    117. Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation. Acta Pharm Sin B. 2021 Mar; 11(3):727-737. Gao Y, Fan S, Li H, Jiang Y, Yao X, Zhu S, Yang X, Wang R, Tian J, Gonzalez FJ, Huang M, Bi H. PMID: 33777678; PMCID: PMC7982502.
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    118. Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting. Nat Commun. 2020 11 17; 11(1):5847. Brocker CN, Kim D, Melia T, Karri K, Velenosi TJ, Takahashi S, Aibara D, Bonzo JA, Levi M, Waxman DJ, Gonzalez FJ. PMID: 33203882; PMCID: PMC7673042.
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    119. Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1. J Med Chem. 2020 11 25; 63(22):14087-14117. Alverez CN, Park JE, Toti KS, Xia Y, Krausz KW, Rai G, Bang JK, Gonzalez FJ, Jacobson KA, Lee KS. PMID: 33175530; PMCID: PMC7769008.
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    120. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorg Med Chem. 2021 01 01; 29:115851. Xia YL, Wang JJ, Li SY, Liu Y, Gonzalez FJ, Wang P, Ge GB. PMID: 33218896; PMCID: PMC7855844.
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    121. MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis. Mol Pharmacol. 2020 12; 98(6):686-694. Tu MJ, Duan Z, Liu Z, Zhang C, Bold RJ, Gonzalez FJ, Kim EJ, Yu AM. PMID: 33051382; PMCID: PMC7673485.
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    122. PPARα mediates night neon light-induced weight gain: role of lipid homeostasis. Theranostics. 2020; 10(25):11497-11506. Luo Y, Yang J, Kang J, Chen K, Jin X, Gonzalez FJ, Liu A. PMID: 33052228; PMCID: PMC7545995.
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    123. Improved detection and precise relative quantification of the urinary cancer metabolite biomarkers - Creatine riboside, creatinine riboside, creatine and creatinine by UPLC-ESI-MS/MS: Application to the NCI-Maryland cohort population controls and lung cancer cases. J Pharm Biomed Anal. 2020 Nov 30; 191:113596. Patel DP, Pauly GT, Tada T, Parker AL, Toulabi L, Kanke Y, Oike T, Krausz KW, Gonzalez FJ, Harris CC. PMID: 32937240; PMCID: PMC7756200.
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    124. Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice. Toxicol Lett. 2020 Oct 15; 333:290-302. Zhao J, Xie C, Wang K, Takahashi S, Krausz KW, Lu D, Wang Q, Luo Y, Gong X, Mu X, Wang Q, Su S, Gonzalez FJ. PMID: 32835833; PMCID: PMC7783549.
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    125. Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice. Mol Neurobiol. 2020 Nov; 57(11):4608-4621. Stocco MR, Tolledo C, Wadji FB, Gonzalez FJ, Miksys S, Tyndale RF. PMID: 32761352; PMCID: PMC8865091.
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    126. Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases. J Pharm Pharmacol. 2020 Dec; 72(12):1865-1878. Xing H, Yang J, Ren K, Qin Z, Wang P, Zhang X, Yao Z, Gonzalez FJ, Yao X. PMID: 32750744; PMCID: PMC8861878.
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    127. Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6β-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation. Hypertension. 2020 09; 76(3):1006-1018. Singh P, Dutta SR, Song CY, Oh S, Gonzalez FJ, Malik KU. PMID: 32755412; PMCID: PMC7418933.
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    128. HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1. Biochim Biophys Acta Mol Basis Dis. 2020 11 01; 1866(11):165898. Sato Y, Rahman MM, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez FJ, Yamamura KI, Yamagata K. PMID: 32711050; PMCID: PMC8865093.
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    129. Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. Liver Cancer. 2020 Sep; 9(5):529-548. Jia F, Diao P, Wang X, Hu X, Kimura T, Nakamuta M, Nakamura I, Shirotori S, Sato Y, Moriya K, Koike K, Gonzalez FJ, Nakayama J, Aoyama T, Tanaka N. PMID: 33083279; PMCID: PMC7548900.
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    130. Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells. J Pharm Pharmacol. 2020 Dec; 72(12):1771-1786. Li Y, Xu C, Xu J, Qin Z, Li S, Hu L, Yao Z, Gonzalez FJ, Yao X. PMID: 32648321; PMCID: PMC8865092.
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    131. A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice. J Nutr Biochem. 2020 11; 85:108460. Diao P, Wang X, Jia F, Kimura T, Hu X, Shirotori S, Nakamura I, Sato Y, Nakayama J, Moriya K, Koike K, Gonzalez FJ, Aoyama T, Tanaka N. PMID: 32992072; PMCID: PMC7756930.
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    132. Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation. Drug Metab Dispos. 2020 09; 48(9):830-839. Jiao T, Yao X, Zhao Y, Zhou Y, Gao Y, Fan S, Chen P, Li X, Jiang Y, Yang X, Gonzalez FJ, Huang M, Bi H. PMID: 32561593; PMCID: PMC7497622.
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    133. Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH. Biochem Biophys Res Commun. 2020 09 17; 530(2):432-439. Kasano-Camones CI, Takizawa M, Iwasaki W, Sasaki S, Hamada M, Morimoto A, Sakaguchi M, Gonzalez FJ, Inoue Y. PMID: 32553626; PMCID: PMC7484291.
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    134. A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics. 2020; 10(16):7193-7210. Chen Y, Zhou Y, Han F, Zhao Y, Tu M, Wang Y, Huang C, Fan S, Chen P, Yao X, Guan L, Yu AM, Gonzalez FJ, Huang M, Bi H. PMID: 32641987; PMCID: PMC7330864.
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    135. Celastrol ameliorates acute liver injury through modulation of PPARα. Biochem Pharmacol. 2020 08; 178:114058. Zhao Q, Tang P, Zhang T, Huang JF, Xiao XR, Zhu WF, Gonzalez FJ, Li F. PMID: 32470546; PMCID: PMC7377972.
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    136. Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα. JCI Insight. 2020 05 21; 5(10). Patel D, Roy A, Raha S, Kundu M, Gonzalez FJ, Pahan K. PMID: 32315292; PMCID: PMC7259538.
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    137. Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice. J Endocrinol. 2020 05; 245(2):301-314. Konstandi M, Andriopoulou CE, Cheng J, Gonzalez FJ. PMID: 32171179; PMCID: PMC7202972.
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    138. A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice. Carcinogenesis. 2020 04 22; 41(2):159-170. Hu X, Wang X, Jia F, Tanaka N, Kimura T, Nakajima T, Sato Y, Moriya K, Koike K, Gonzalez FJ, Nakayama J, Aoyama T. PMID: 31300810; PMCID: PMC8456504.
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    139. Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence. J Pharm Anal. 2021 Jun; 11(3):340-350. Zhang H, Wang Y, Guan L, Chen Y, Chen P, Sun J, Gonzalez FJ, Huang M, Bi H. PMID: 34277122; PMCID: PMC8264383.
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    140. Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. Aging (Albany NY). 2020 04 14; 12(8):6733-6755. Wang Y, Yu T, Zhou Y, Wang S, Zhou X, Wang L, Ou T, Chen Y, Zhou Y, Zhang H, Wang Y, Fan X, Chen P, Gonzalez FJ, Yu A, Huang P, Huang M, Bi H. PMID: 32289751; PMCID: PMC7202531.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    141. Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications. J Pharm Anal. 2021 Feb; 11(1):15-27. Wang FY, Wang P, Zhao DF, Gonzalez FJ, Fan YF, Xia YL, Ge GB, Yang L. PMID: 33717608; PMCID: PMC7930641.
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    142. Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells. Xenobiotica. 2020 Aug; 50(8):997-1008. Li Y, Xu J, Xu C, Qin Z, Li S, Hu L, Yao Z, Gonzalez FJ, Yao X. PMID: 32116078; PMCID: PMC7396962.
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    143. Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice. Mol Neurobiol. 2020 Jun; 57(6):2509-2520. Tolledo C, Stocco MR, Miksys S, Gonzalez FJ, Tyndale RF. PMID: 32189192; PMCID: PMC7383223.
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    144. PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice. Int J Mol Sci. 2020 Mar 17; 21(6). Wang Y, Nakajima T, Gonzalez FJ, Tanaka N. PMID: 32192216; PMCID: PMC7139552.
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    145. Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites. Hum Genomics. 2020 03 11; 14(1):10. Brocker CN, Velenosi T, Flaten HK, McWilliams G, McDaniel K, Shelton SK, Saben J, Krausz KW, Gonzalez FJ, Monte AA. PMID: 32160915; PMCID: PMC7066769.
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    146. Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice. Hypertension. 2020 04; 75(4):1054-1062. Singh P, Song CY, Dutta SR, Gonzalez FJ, Malik KU. PMID: 32148125; PMCID: PMC7098446.
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    147. Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice. J Biol Chem. 2020 04 03; 295(14):4733-4747. Takahashi S, Luo Y, Ranjit S, Xie C, Libby AE, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M. PMID: 32075905; PMCID: PMC7135973.
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    148. 6β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice. Biol Sex Differ. 2020 01 16; 11(1):4. Pingili AK, Jennings BL, Mukherjee K, Akroush W, Gonzalez FJ, Malik KU. PMID: 31948482; PMCID: PMC6966856.
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    149. SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis. Nat Commun. 2020 01 13; 11(1):240. Zhou J, Cui S, He Q, Guo Y, Pan X, Zhang P, Huang N, Ge C, Wang G, Gonzalez FJ, Wang H, Hao H. PMID: 31932588; PMCID: PMC6957516.
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    150. Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses. Br J Pharmacol. 2020 02; 177(3):701-712. Tolledo EC, Miksys S, Gonzalez FJ, Tyndale RF. PMID: 31648367; PMCID: PMC7012948.
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    151. Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis. Free Radic Biol Med. 2020 02 20; 148:33-41. Zhang Y, Yan T, Sun D, Xie C, Wang T, Liu X, Wang J, Wang Q, Luo Y, Wang P, Yagai T, Krausz KW, Yang X, Gonzalez FJ. PMID: 31874248; PMCID: PMC7376370.
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    152. Herbal drug discovery for the treatment of nonalcoholic fatty liver disease. Acta Pharm Sin B. 2020 Jan; 10(1):3-18. Yan T, Yan N, Wang P, Xia Y, Hao H, Wang G, Gonzalez FJ. PMID: 31993304; PMCID: PMC6977016.
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    153. A multiparametric organ toxicity predictor for drug discovery. Toxicol Mech Methods. 2020 Mar; 30(3):159-166. Patel CN, Kumar SP, Rawal RM, Patel DP, Gonzalez FJ, Pandya HA. PMID: 31618094; PMCID: PMC7383222.
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    154. Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis. NPJ Precis Oncol. 2019; 3:26. Peters JM, Walter V, Patterson AD, Gonzalez FJ. PMID: 31602402; PMCID: PMC6779880.
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    155. The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria. Sci Adv. 2019 09; 5(9):eaaw6127. Wang P, Sachar M, Lu J, Shehu AI, Zhu J, Chen J, Liu K, Anderson KE, Xie W, Gonzalez FJ, Klaassen CD, Ma X. PMID: 31555729; PMCID: PMC6750912.
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    156. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 10 21; 32(10):1965-1976. Yang XN, Wang YK, Zhu X, Xiao XR, Dai MY, Zhang T, Qu Y, Yang XW, Qin HB, Gonzalez FJ, Li F. PMID: 31468958; PMCID: PMC7397737.
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    157. Publisher Correction: Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019 Sep; 25(9):1459. Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, Wang L, Zhang Y, Liang X, Wang L, Gonzalez FJ, Patterson AD, Liu H, Mu L, Zhou Z, Zhao Y, Li R, Liu P, Zhong C, Pang Y, Jiang C, Qiao J. PMID: 31471570.
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    158. The Protective Roles of PPARα Activation in Triptolide-Induced Liver Injury. Toxicol Sci. 2019 Sep 01; 171(1):1-12. Hu DD, Zhao Q, Cheng Y, Xiao XR, Huang JF, Qu Y, Li X, Tang YM, Bao WM, Yang JH, Jiang T, Hu JP, Gonzalez FJ, Li F. PMID: 31241159; PMCID: PMC11514144.
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    159. Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. Cell. 2019 08 22; 178(5):1102-1114.e17. Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE, Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M. PMID: 31442403; PMCID: PMC7357241.
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    160. Withaferin A Improves Nonalcoholic Steatohepatitis in Mice. J Pharmacol Exp Ther. 2019 11; 371(2):360-374. Patel DP, Yan T, Kim D, Dias HB, Krausz KW, Kimura S, Gonzalez FJ. PMID: 31420528; PMCID: PMC6800446.
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    161. Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on α-synuclein protein levels. Biochem Pharmacol. 2019 10; 168:429-437. González-Barbosa E, García-Aguilar R, Vega L, Cabañas-Cortés MA, Gonzalez FJ, Segovia J, Morales-Lázaro SL, Cisneros B, Elizondo G. PMID: 31404530; PMCID: PMC7376371.
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    162. Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma. Cancer Epidemiol Biomarkers Prev. 2019 10; 28(10):1704-1711. Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC. PMID: 31358519; PMCID: PMC6774833.
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    163. Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis. Free Radic Biol Med. 2019 11 01; 143:127-139. Chen Y, Manna SK, Golla S, Krausz KW, Cai Y, Garcia-Milian R, Chakraborty T, Chakraborty J, Chatterjee R, Thompson DC, Gonzalez FJ, Vasiliou V. PMID: 31351176; PMCID: PMC6848780.
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    164. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019 08; 25(8):1225-1233. Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, Wang L, Zhang Y, Liang X, Wang L, Gonzalez FJ, Patterson AD, Liu H, Mu L, Zhou Z, Zhao Y, Li R, Liu P, Zhong C, Pang Y, Jiang C, Qiao J. PMID: 31332392; PMCID: PMC7376369.
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    165. Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death Dis. 2019 07 18; 10(8):544. Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, Taranto J, Liu Y, Duan Y, Yu B, Li H, Shah YM, Xu Q, Du J, Gonzalez FJ, Qu A. PMID: 31320613; PMCID: PMC6639417.
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    166. Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity. J Agric Food Chem. 2019 Jul 24; 67(29):8243-8252. Wang YK, Yang XN, Zhu X, Xiao XR, Yang XW, Qin HB, Gonzalez FJ, Li F. PMID: 31271289; PMCID: PMC7385589.
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    167. Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation. FEBS J. 2019 11; 286(21):4328-4341. Konstandi M, Kypreos KE, Matsubara T, Xepapadaki E, Shah YM, Krausz K, Andriopoulou CE, Kofinas A, Gonzalez FJ. PMID: 31230416; PMCID: PMC6829030.
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    168. Non-targeted metabolomics reveals diagnostic biomarker in the tongue coating of patients with chronic gastritis. J Pharm Biomed Anal. 2019 Sep 10; 174:541-551. Mu X, Ji C, Wang Q, Liu K, Hao X, Zhang G, Shi X, Zhang Y, Gonzalez FJ, Wang Q, Wang Y. PMID: 31255854; PMCID: PMC7383221.
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    169. Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 10; 1864(10):1396-1411. Xie C, Takahashi S, Brocker CN, He S, Chen L, Xie G, Jang K, Gao X, Krausz KW, Qu A, Levi M, Gonzalez FJ. PMID: 31195146; PMCID: PMC7423166.
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    170. Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1. PLoS One. 2019; 14(5):e0217695. Zhang B, Yang J, Qin Z, Li S, Xu J, Yao Z, Zhang X, Gonzalez FJ, Yao X. PMID: 31150474; PMCID: PMC6544300.
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    171. Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6. Gastroenterology. 2019 09; 157(3):744-759.e4. Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ. PMID: 31154022; PMCID: PMC7388731.
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    172. β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes. Cell Rep. 2019 05 21; 27(8):2370-2384.e6. Lalwani A, Warren J, Liuwantara D, Hawthorne WJ, O'Connell PJ, Gonzalez FJ, Stokes RA, Chen J, Laybutt DR, Craig ME, Swarbrick MM, King C, Gunton JE. PMID: 31116982; PMCID: PMC6661122.
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    173. Hepatocyte Nuclear Factor 4-Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver. Hepatology. 2019 10; 70(4):1360-1376. Thakur A, Wong JCH, Wang EY, Lotto J, Kim D, Cheng JC, Mingay M, Cullum R, Moudgil V, Ahmed N, Tsai SH, Wei W, Walsh CP, Stephan T, Bilenky M, Fuglerud BM, Karimi MM, Gonzalez FJ, Hirst M, Hoodless PA. PMID: 30933372; PMCID: PMC6773525.
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    174. The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors. Front Pharmacol. 2019; 10:496. Qin Z, Zhang B, Yang J, Li S, Xu J, Yao Z, Zhang X, Gonzalez FJ, Yao X. PMID: 31133859; PMCID: PMC6515931.
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    175. Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity. Br J Pharmacol. 2019 07; 176(13):2162-2178. Zhao Q, Zhang T, Xiao XR, Huang JF, Wang Y, Gonzalez FJ, Li F. PMID: 30875096; PMCID: PMC6555861.
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    176. Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer. Mol Carcinog. 2019 09; 58(9):1612-1622. Peters JM, Kim DJ, Bility MT, Borland MG, Zhu B, Gonzalez FJ. PMID: 31062422; PMCID: PMC6692234.
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    177. Pregnane X receptor activation potentiates ritonavir hepatotoxicity. J Clin Invest. 2019 04 30; 129(7):2898-2903. Shehu AI, Lu J, Wang P, Zhu J, Wang Y, Yang D, McMahon D, Xie W, Gonzalez FJ, Ma X. PMID: 31039134; PMCID: PMC6597219.
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    178. Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation. Hepatology. 2019 07; 70(1):154-167. Kim D, Brocker CN, Takahashi S, Yagai T, Kim T, Xie G, Wang H, Qu A, Gonzalez FJ. PMID: 30697791; PMCID: PMC6597269.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    179. Hepatic metabolic adaptation in a murine model of glutathione deficiency. Chem Biol Interact. 2019 Apr 25; 303:1-6. Chen Y, Golla S, Garcia-Milian R, Thompson DC, Gonzalez FJ, Vasiliou V. PMID: 30794799; PMCID: PMC6743730.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    180. Modulation of Lipid Metabolism by Celastrol. J Proteome Res. 2019 03 01; 18(3):1133-1144. Zhang T, Zhao Q, Xiao X, Yang R, Hu D, Zhu X, Gonzalez FJ, Li F. PMID: 30706713; PMCID: PMC6626529.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    181. In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice. Toxicology. 2019 03 01; 415:49-55. Hayashi Y, Ito Y, Naito H, Tamada H, Yamagishi N, Kondo T, Ishikawa T, Gonzalez FJ, Nakajima T. PMID: 30660623; PMCID: PMC6628919.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    182. Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling. Mol Cell Proteomics. 2019 03; 18(3):520-533. Zhao Q, Liu F, Cheng Y, Xiao XR, Hu DD, Tang YM, Bao WM, Yang JH, Jiang T, Hu JP, Gonzalez FJ, Li F. PMID: 30617157; PMCID: PMC6398203.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    183. Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis. Psychopharmacology (Berl). 2019 Jun; 236(6):1687-1699. Konstandi M, Sotiropoulos I, Matsubara T, Malliou F, Katsogridaki A, Andriopoulou CE, Gonzalez FJ. PMID: 30612190; PMCID: PMC6643287.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    184. Endothelial Cell-Targeted Deletion of PPARγ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue. J Pharmacol Exp Ther. 2019 03; 368(3):514-523. Akiyama TE, Skelhorne-Gross GE, Lightbody ED, Rubino RE, Shi JY, McNamara LA, Sharma N, Zycband EI, Gonzalez FJ, Liu H, Woods JW, Chang CH, Berger JP, Nicol CJB. PMID: 30606762; PMCID: PMC11047031.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    185. A systemic workflow for profiling metabolome and lipidome in tissue. J Chromatogr A. 2019 Mar 29; 1589:105-115. Lu D, Xue L, Feng C, Jin Y, Wu C, Xie C, Gonzalez FJ, Wang G, Zhou Z. PMID: 30638710; PMCID: PMC6628932.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    186. Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice. Hepatology. 2019 01; 69(1):343-358. Jiang Y, Feng D, Ma X, Fan S, Gao Y, Fu K, Wang Y, Sun J, Yao X, Liu C, Zhang H, Xu L, Liu A, Gonzalez FJ, Yang Y, Gao B, Huang M, Bi H. PMID: 30048004; PMCID: PMC6324985.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    187. Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis. Xenobiotica. 2019 May; 49(5):591-601. Wang BL, Zhang CW, Wang L, Tang KL, Tanaka N, Gonzalez FJ, Xu Y, Fang ZZ. PMID: 29737914; PMCID: PMC6643298.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    188. The role of hypoxia-inducible factors in metabolic diseases. Nat Rev Endocrinol. 2018 12; 15(1):21-32. Gonzalez FJ, Xie C, Jiang C. PMID: 30275460; PMCID: PMC6624429.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansAnimalsCells
    189. Cigarette Smoke Toxins-Induced Mitochondrial Dysfunction and Pancreatitis Involves Aryl Hydrocarbon Receptor Mediated Cyp1 Gene Expression: Protective Effects of Resveratrol. Toxicol Sci. 2018 Dec 01; 166(2):428-440. Ghosh J, Chowdhury AR, Srinivasan S, Chattopadhyay M, Bose M, Bhattacharya S, Raza H, Fuchs SY, Rustgi AK, Gonzalez FJ, Avadhani NG. PMID: 30165701; PMCID: PMC6260170.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    190. Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ. Mol Cell Biol. 2018 12 15; 38(24). Sasaki S, Urabe M, Maeda T, Suzuki J, Irie R, Suzuki M, Tomaru Y, Sakaguchi M, Gonzalez FJ, Inoue Y. PMID: 30224520; PMCID: PMC6275183.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    191. Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice. Am J Pathol. 2019 02; 189(2):272-282. Xie G, Yin S, Zhang Z, Qi D, Wang X, Kim D, Yagai T, Brocker CN, Wang Y, Gonzalez FJ, Wang H, Qu A. PMID: 30448405; PMCID: PMC6593252.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    192. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nat Med. 2018 12; 24(12):1919-1929. Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C. PMID: 30397356; PMCID: PMC6479226.
      View in: PubMed   Mentions: 491     Fields:    Translation:HumansCells
    193. Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models. Cancer Lett. 2019 02 01; 442:82-90. Tu MJ, Ho PY, Zhang QY, Jian C, Qiu JX, Kim EJ, Bold RJ, Gonzalez FJ, Bi H, Yu AM. PMID: 30389433; PMCID: PMC6311422.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    194. Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice. Arch Toxicol. 2019 01; 93(1):149-161. Lu Y, Harada M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Kyogashima M, Gonzalez FJ, Aoyama T. PMID: 30341732; PMCID: PMC6661123.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    195. Efflux excretion of bisdemethoxycurcumin-O-glucuronide in UGT1A1-overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 (MRP1) as the glucuronide transporters. Biofactors. 2018 Nov; 44(6):558-569. Yang J, Zhang B, Qin Z, Li S, Xu J, Yao Z, Zhang X, Gonzalez FJ, Yao X. PMID: 30334318; PMCID: PMC7383220.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    196. Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis. EBioMedicine. 2018 Nov; 37:322-333. Wang H, Ge C, Zhou J, Guo Y, Cui S, Huang N, Yan T, Cao L, Che Y, Zheng Q, Zheng X, Gonzalez FJ, Wang G, Hao H. PMID: 30337250; PMCID: PMC6286639.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    197. Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development. Hepatol Commun. 2018 Dec; 2(12):1567-1582. Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ. PMID: 30556042; PMCID: PMC6287584.
      View in: PubMed   Mentions: 31     Fields:    
    198. Molecular Regulation of Carcinogenesis: Friend and Foe. Toxicol Sci. 2018 10 01; 165(2):277-283. Patterson AD, Gonzalez FJ, Perdew GH, Peters JM. PMID: 30053205; PMCID: PMC6154271.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    199. The Evolution of Carcinogenesis. Toxicol Sci. 2018 10 01; 165(2):272-276. Peters JM, Gonzalez FJ. PMID: 30629266; PMCID: PMC6154269.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    200. PPARα-independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling. J Pharm Pharmacol. 2018 Dec; 70(12):1630-1642. Hua H, Yang J, Lin H, Xi Y, Dai M, Xu G, Wang F, Liu L, Zhao T, Huang J, Gonzalez FJ, Liu A. PMID: 30251457; PMCID: PMC6281295.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    201. Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice. J Am Heart Assoc. 2018 09 18; 7(18):e010065. Mukherjee K, Song CY, Estes AM, Dhodi AN, Ormseth BH, Shin JS, Gonzalez FJ, Malik KU. PMID: 30371217; PMCID: PMC6222936.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    202. The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells. Chem Biol Interact. 2018 Dec 25; 296:45-56. Li S, Xu J, Yao Z, Hu L, Qin Z, Gao H, Krausz KW, Gonzalez FJ, Yao X. PMID: 30237061; PMCID: PMC6628920.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    203. Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice. J Lipid Res. 2018 11; 59(11):2140-2152. Brocker CN, Patel DP, Velenosi TJ, Kim D, Yan T, Yue J, Li G, Krausz KW, Gonzalez FJ. PMID: 30158201; PMCID: PMC6210912.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    204. The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation. Cell Death Differ. 2019 05; 26(5):890-901. Battistelli C, Sabarese G, Santangelo L, Montaldo C, Gonzalez FJ, Tripodi M, Cicchini C. PMID: 30154449; PMCID: PMC6461983.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    205. A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice. Xenobiotica. 2019 Jun; 49(6):655-670. Wang YK, Yang XN, Liang WQ, Xiao Y, Zhao Q, Xiao XR, Gonzalez FJ, Li F. PMID: 29897827; PMCID: PMC6628935.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    206. Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):E7408-E7417. Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K. PMID: 30012602; PMCID: PMC6077698.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    207. Metabolic alterations in triptolide-induced acute hepatotoxicity. Biomed Chromatogr. 2018 Oct; 32(10):e4299. Zhao J, Xie C, Mu X, Krausz KW, Patel DP, Shi X, Gao X, Wang Q, Gonzalez FJ. PMID: 29799631; PMCID: PMC6150827.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    208. Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation. Drug Metab Dispos. 2018 09; 46(9):1310-1319. Yan T, Wang H, Cao L, Wang Q, Takahashi S, Yagai T, Li G, Krausz KW, Wang G, Gonzalez FJ, Hao H. PMID: 29959134; PMCID: PMC6081736.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    209. In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP-glucuronosyltransferase enzymes by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. J Pharm Biomed Anal. 2018 Sep 05; 158:351-360. Xu J, Li M, Yao Z, Zhang Y, Li S, Hu L, Qin Z, Gonzalez FJ, Yao X. PMID: 29933228; PMCID: PMC7396963.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    210. The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides. J Nutr Biochem. 2018 09; 59:17-28. Malliou F, Andreadou I, Gonzalez FJ, Lazou A, Xepapadaki E, Vallianou I, Lambrinidis G, Mikros E, Marselos M, Skaltsounis AL, Konstandi M. PMID: 29960113; PMCID: PMC6628917.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    211. Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism. Hepatology. 2018 10; 68(4):1574-1588. Pathak P, Xie C, Nichols RG, Ferrell JM, Boehme S, Krausz KW, Patterson AD, Gonzalez FJ, Chiang JYL. PMID: 29486523; PMCID: PMC6111007.
      View in: PubMed   Mentions: 249     Fields:    Translation:AnimalsCells
    212. Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation. Cancer Med. 2018 06; 7(6):2764-2775. Haznadar M, Krausz KW, Margono E, Diehl CM, Bowman ED, Manna SK, Robles AI, Ryan BM, Gonzalez FJ, Harris CC. PMID: 29726119; PMCID: PMC6010700.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    213. Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells. Toxicology. 2018 07 01; 404-405:25-32. Borland MG, Kehres EM, Lee C, Wagner AL, Shannon BE, Albrecht PP, Zhu B, Gonzalez FJ, Peters JM. PMID: 29729928; PMCID: PMC6026558.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    214. Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance. EBioMedicine. 2018 May; 31:202-216. Zhang SY, Dong YQ, Wang P, Zhang X, Yan Y, Sun L, Liu B, Zhang D, Zhang H, Liu H, Kong W, Hu G, Shah YM, Gonzalez FJ, Wang X, Jiang C. PMID: 29735414; PMCID: PMC6013933.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    215. PPARα Mediates the Hepatoprotective Effects of Nutmeg. J Proteome Res. 2018 05 04; 17(5):1887-1897. Yang XN, Liu XM, Fang JH, Zhu X, Yang XW, Xiao XR, Huang JF, Gonzalez FJ, Li F. PMID: 29664296; PMCID: PMC6628927.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    216. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis. Drug Metab Dispos. 2018 07; 46(7):1030-1040. Zhang Y, Yan T, Sun D, Xie C, Zheng Y, Zhang L, Yagai T, Krausz KW, Bisson WH, Yang X, Gonzalez FJ. PMID: 29691238; PMCID: PMC6003592.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    217. Metabolic profiling of corylin in vivo and in vitro. J Pharm Biomed Anal. 2018 Jun 05; 155:157-168. Qin Z, Li S, Yao Z, Hong X, Xu J, Lin P, Zhao G, Gonzalez FJ, Yao X. PMID: 29631076; PMCID: PMC6666405.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    218. Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by α-Naphthylisothiocyanate. J Proteome Res. 2018 04 06; 17(4):1500-1508. Dai M, Hua H, Lin H, Xu G, Hu X, Li F, Gonzalez FJ, Liu A, Yang J. PMID: 29498526; PMCID: PMC6628934.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    219. Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643. J Gastroenterol Hepatol. 2018 May; 33(5):1138-1145. Li G, Brocker CN, Xie C, Yan T, Noguchi A, Krausz KW, Xiang R, Gonzalez FJ. PMID: 29141109; PMCID: PMC6334298.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    220. Fat-specific protein 27 is a novel target gene of liver X receptor α. Mol Cell Endocrinol. 2018 10 15; 474:48-56. Aibara D, Matsusue K, Takiguchi S, Gonzalez FJ, Yamano S. PMID: 29454584; PMCID: PMC6594021.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    221. Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89]. Mol Metab. 2018 03; 9:217-219. Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ. PMID: 29396375; PMCID: PMC5870094.
      View in: PubMed   Mentions:    Fields:    
    222. Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice. Hepatology. 2018 03; 67(3):1071-1087. Ou-Yang Q, Lin XM, Zhu YJ, Zheng B, Li L, Yang YC, Hou GJ, Chen X, Luo GJ, Huo F, Leng QB, Gonzalez FJ, Jiang XQ, Wang HY, Chen L. PMID: 28960380; PMCID: PMC6661113.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    223. Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In Vitro. Drug Metab Dispos. 2018 04; 46(4):336-345. Xie C, Gao X, Sun D, Zhang Y, Krausz KW, Qin X, Gonzalez FJ. PMID: 29363499; PMCID: PMC5829541.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    224. Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study. Biomed Chromatogr. 2018 May; 32(5):e4165. Nair SG, Patel DP, Gonzalez FJ, Patel BM, Singhal P, Chaudhary DV. PMID: 29228469; PMCID: PMC6643291.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    225. Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides. Food Funct. 2018 Mar 01; 9(3):1410-1423. Qin Z, Li S, Yao Z, Hong X, Wu B, Krausz KW, Gonzalez FJ, Gao H, Yao X. PMID: 29318243.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    226. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death Differ. 2018 03; 25(4):735-748. Wang Y, Chen Y, Guan L, Zhang H, Huang Y, Johnson CH, Wu Z, Gonzalez FJ, Yu A, Huang P, Wang Y, Yang S, Chen P, Fan X, Huang M, Bi H. PMID: 29317762; PMCID: PMC5864250.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    227. Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease. J Biomol Struct Dyn. 2018 Nov; 36(15):3938-3957. Patel CN, Georrge JJ, Modi KM, Narechania MB, Patel DP, Gonzalez FJ, Pandya HA. PMID: 29281938; PMCID: PMC6371058.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    228. Hepatic Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) regulates metabolism in mice. PLoS One. 2017; 12(11):e0186543. Scott CH, Cha KM, Ngai J, Jiang C, Cheng K, Stokes RA, Ho KWK, George J, Gonzalez FJ, Gunton JE. PMID: 29190746; PMCID: PMC5708799.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    229. Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice. J Biol Chem. 2018 01 05; 293(1):1-17. Choi S, Neequaye P, French SW, Gonzalez FJ, Gyamfi MA. PMID: 29123032; PMCID: PMC5766906.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    230. Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha. Mol Metab. 2018 01; 7:80-89. Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ. PMID: 29146411; PMCID: PMC5784329.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    231. FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018 01; 29(1):118-137. Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D'Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M. PMID: 29089371; PMCID: PMC5748904.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    232. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov; 23(11):1298-1308. Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ. PMID: 29035368; PMCID: PMC6410352.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    233. Editor's Highlight: PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis. Toxicol Sci. 2017 10 01; 159(2):436-448. Borland MG, Yao PL, Kehres EM, Lee C, Pritzlaff AM, Ola E, Wagner AL, Shannon BE, Albrecht PP, Zhu B, Kang BH, Robertson GP, Gonzalez FJ, Peters JM. PMID: 28962521; PMCID: PMC5837686.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    234. In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes. Int J Mol Sci. 2017 Sep 19; 18(9). Hong X, Zheng Y, Qin Z, Wu B, Dai Y, Gao H, Yao Z, Gonzalez FJ, Yao X. PMID: 28925930; PMCID: PMC5618632.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    235. Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota. Cell Metab. 2017 Oct 03; 26(4):672-685.e4. Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ. PMID: 28918936; PMCID: PMC5668683.
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    236. Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice. Biomol Ther (Seoul). 2017 Sep 01; 25(5):504-510. Kim T, Wahyudi LD, Gonzalez FJ, Kim JH. PMID: 28190320; PMCID: PMC5590794.
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    237. Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. Biochim Biophys Acta Mol Basis Dis. 2017 12; 1863(12):3170-3182. Tanaka N, Takahashi S, Hu X, Lu Y, Fujimori N, Golla S, Fang ZZ, Aoyama T, Krausz KW, Gonzalez FJ. PMID: 28844958; PMCID: PMC5675002.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    238. A Western diet-induced mouse model reveals a possible mechanism by which metformin decreases obesity. Eur J Clin Pharmacol. 2017 Oct; 73(10):1337-1339. Gonzalez FJ, Jiang C. PMID: 28831566; PMCID: PMC5693664.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    239. Inhibition of JNK signalling mediates PPARα-dependent protection against intrahepatic cholestasis by fenofibrate. Br J Pharmacol. 2017 Sep; 174(18):3000-3017. Dai M, Yang J, Xie M, Lin J, Luo M, Hua H, Xu G, Lin H, Song D, Cheng Y, Guo B, Zhao J, Gonzalez FJ, Liu A. PMID: 28646549; PMCID: PMC5573431.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    240. Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway. Toxicol Sci. 2017 08 01; 158(2):334-346. Takahashi S, Tanaka N, Golla S, Fukami T, Krausz KW, Polunas MA, Weig BC, Masuo Y, Xie C, Jiang C, Gonzalez FJ. PMID: 28505368; PMCID: PMC5837376.
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    241. Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung. Biochem Biophys Res Commun. 2017 09 16; 491(2):271-276. Kim JH, Yamaori S, Tanabe T, Takagi M, Matsubara T, Okamoto M, Kimura S, Gonzalez FJ. PMID: 28739257; PMCID: PMC6291199.
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    242. Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes. Chemosphere. 2017 Oct; 185:983-990. Cao YF, Du Z, Zhu ZT, Sun HZ, Fu ZW, Yang K, Liu YZ, Hu CM, Dong PP, Gonzalez FJ, Fang ZZ. PMID: 28753904; PMCID: PMC6331009.
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    243. Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation. Anal Chem. 2017 08 01; 89(15):7900-7906. Cai J, Zhang J, Tian Y, Zhang L, Hatzakis E, Krausz KW, Smith PB, Gonzalez FJ, Patterson AD. PMID: 28650151; PMCID: PMC6334302.
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    244. Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation. J Hypertens. 2017 07; 35(7):1390-1401. Idris-Khodja N, Ouerd S, Trindade M, Gornitsky J, Rehman A, Barhoumi T, Offermanns S, Gonzalez FJ, Neves MF, Paradis P, Schiffrin EL. PMID: 28234672; PMCID: PMC6338076.
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    245. TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain. J Biochem Mol Toxicol. 2017 Oct; 31(10). González-Barbosa E, Mejía-García A, Bautista E, Gonzalez FJ, Segovia J, Elizondo G. PMID: 28621812; PMCID: PMC6309283.
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    246. T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD. Blood. 2017 07 20; 130(3):348-359. Dant TA, Lin KL, Bruce DW, Montgomery SA, Kolupaev OV, Bommiasamy H, Bixby LM, Woosley JT, McKinnon KP, Gonzalez FJ, Blazar BR, Vincent BG, Coghill JM, Serody JS. PMID: 28550042; PMCID: PMC5520467.
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    247. Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption. Toxicology. 2017 07 01; 386:133-142. Wang H, Fang ZZ, Meng R, Cao YF, Tanaka N, Krausz KW, Gonzalez FJ. PMID: 28549656; PMCID: PMC5594256.
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    248. Targeting nuclear receptors for the treatment of fatty liver disease. Pharmacol Ther. 2017 Nov; 179:142-157. Tanaka N, Aoyama T, Kimura S, Gonzalez FJ. PMID: 28546081; PMCID: PMC6659998.
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    249. Inflammation is independent of steatosis in a murine model of steatohepatitis. Hepatology. 2017 07; 66(1):108-123. Wang W, Xu MJ, Cai Y, Zhou Z, Cao H, Mukhopadhyay P, Pacher P, Zheng S, Gonzalez FJ, Gao B. PMID: 28220523; PMCID: PMC5481491.
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    250. Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice. PLoS One. 2017; 12(5):e0177953. Patel DP, Krausz KW, Xie C, Beyoglu D, Gonzalez FJ, Idle JR. PMID: 28520815; PMCID: PMC5433781.
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    251. Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes. Xenobiotica. 2018 Apr; 48(4):357-367. Wang L, Hong X, Yao Z, Dai Y, Zhao G, Qin Z, Wu B, Gonzalez FJ, Yao X. PMID: 28443723; PMCID: PMC6300989.
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    252. Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. Sci Rep. 2017 05 11; 7(1):1748. Sheng L, Jena PK, Liu HX, Kalanetra KM, Gonzalez FJ, French SW, Krishnan VV, Mills DA, Wan YY. PMID: 28496104; PMCID: PMC5431816.
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    253. Peroxisome Proliferator-Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil. Basic Clin Pharmacol Toxicol. 2017 Sep; 121(3):169-174. Shi C, Min L, Yang J, Dai M, Song D, Hua H, Xu G, Gonzalez FJ, Liu A. PMID: 28374976; PMCID: PMC5554081.
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    254. An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function. J Biol Chem. 2017 06 23; 292(25):10574-10585. Morimoto A, Kannari M, Tsuchida Y, Sasaki S, Saito C, Matsuta T, Maeda T, Akiyama M, Nakamura T, Sakaguchi M, Nameki N, Gonzalez FJ, Inoue Y. PMID: 28465351; PMCID: PMC5481564.
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    255. Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms. Clin Cancer Res. 2017 Sep 01; 23(17):5302-5310. Patel D, Thompson MD, Manna SK, Krausz KW, Zhang L, Nilubol N, Gonzalez FJ, Kebebew E. PMID: 28450405; PMCID: PMC5581680.
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    256. 2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice. Hypertension. 2017 06; 69(6):1104-1112. Pingili AK, Davidge KN, Thirunavukkarasu S, Khan NS, Katsurada A, Majid DSA, Gonzalez FJ, Navar LG, Malik KU. PMID: 28416584; PMCID: PMC5426976.
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    257. Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis. Cell Metab. 2017 Apr 04; 25(4):856-867.e5. Hao H, Cao L, Jiang C, Che Y, Zhang S, Takahashi S, Wang G, Gonzalez FJ. PMID: 28380377; PMCID: PMC6624427.
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    258. Metabolic map of osthole and its effect on lipids. Xenobiotica. 2018 Mar; 48(3):285-299. Zhao Q, Li XM, Liu HN, Gonzalez FJ, Li F. PMID: 28287022; PMCID: PMC6594145.
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    259. PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis. 2017 04 01; 38(4):474-483. Chen Y, Wang Y, Huang Y, Zeng H, Hu B, Guan L, Zhang H, Yu AM, Johnson CH, Gonzalez FJ, Huang M, Bi H. PMID: 28334197; PMCID: PMC6248526.
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    260. Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis. Fitoterapia. 2017 Jun; 119:26-31. Zhao J, Sun T, Wu JJ, Cao YF, Fang ZZ, Sun HZ, Zhu ZT, Yang K, Liu YZ, Gonzalez FJ, Yin J. PMID: 28344076; PMCID: PMC6300986.
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    261. Potential role of CYP1B1 in the development and treatment of metabolic diseases. Pharmacol Ther. 2017 Oct; 178:18-30. Li F, Zhu W, Gonzalez FJ. PMID: 28322972; PMCID: PMC5600638.
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    262. Schisandrol B protects against cholestatic liver injury through pregnane X receptors. Br J Pharmacol. 2017 04; 174(8):672-688. Zeng H, Jiang Y, Chen P, Fan X, Li D, Liu A, Ma X, Xie W, Liu P, Gonzalez FJ, Huang M, Bi H. PMID: 28128437; PMCID: PMC5368048.
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    263. Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure. Radiat Res. 2017 05; 187(5):612-629. Golla S, Golla JP, Krausz KW, Manna SK, Simillion C, Beyoglu D, Idle JR, Gonzalez FJ. PMID: 28467754; PMCID: PMC5539505.
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    264. Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease. Dig Dis. 2017; 35(3):178-184. Gonzalez FJ, Jiang C, Xie C, Patterson AD. PMID: 28249275; PMCID: PMC6595218.
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    265. Peroxisome proliferator-activated receptor-β/δ modulates mast cell phenotype. Immunology. 2017 04; 150(4):456-467. Yao PL, Morales JL, Gonzalez FJ, Peters JM. PMID: 27935639; PMCID: PMC5343360.
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    266. Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation. Mol Carcinog. 2017 05; 56(5):1472-1483. Yao PL, Chen L, Dobrzanski TP, Zhu B, Kang BH, Müller R, Gonzalez FJ, Peters JM. PMID: 27996177; PMCID: PMC6361394.
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    267. Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 01; 312(3):G283-G299. Brocker CN, Yue J, Kim D, Qu A, Bonzo JA, Gonzalez FJ. PMID: 28082284; PMCID: PMC5401987.
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    268. Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression. Gastroenterology. 2017 04; 152(5):1187-1202. Lin XM, Hu L, Gu J, Wang RY, Li L, Tang J, Zhang BH, Yan XZ, Zhu YJ, Hu CL, Zhou WP, Li S, Liu JF, Gonzalez FJ, Wu MC, Wang HY, Chen L. PMID: 28065789; PMCID: PMC6661112.
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    269. Insulin Represses Fasting-Induced Expression of Hepatic Fat-Specific Protein 27. Biol Pharm Bull. 2017; 40(6):888-893. Matsuo K, Matsusue K, Aibara D, Takiguchi S, Gonzalez FJ, Yamano S. PMID: 28566630; PMCID: PMC7376368.
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    270. Identification, bioactivity evaluation and pharmacokinetics of multiple components in rat serum after oral administration of Xian-Ling-Gu-Bao capsule by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 15; 1041-1042:104-112. Yao ZH, Qin ZF, He LL, Wang XL, Dai Y, Qin L, Gonzalez FJ, Ye WC, Yao XS. PMID: 28033584; PMCID: PMC6338342.
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    271. Risk Factors for Hearing Impairment among Adults with Diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL). J Clin Transl Endocrinol. 2016 Dec; 6:15-22. Bainbridge KE, Cowie CC, Gonzalez F, Hoffman HJ, Dinces E, Stamler J, Cruickshanks KJ. PMID: 28239560; PMCID: PMC5321611.
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    272. Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury. Arch Toxicol. 2017 May; 91(5):2235-2244. Fang ZZ, Tanaka N, Lu D, Jiang CT, Zhang WH, Zhang C, Du Z, Fu ZW, Gao P, Cao YF, Sun HZ, Zhu ZT, Cai Y, Krausz KW, Yao Z, Gonzalez FJ. PMID: 27853831; PMCID: PMC6331015.
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    273. An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice. Diabetes. 2017 03; 66(3):613-626. Xie C, Jiang C, Shi J, Gao X, Sun D, Sun L, Wang T, Takahashi S, Anitha M, Krausz KW, Patterson AD, Gonzalez FJ. PMID: 28223344; PMCID: PMC5319721.
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    274. Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy. J Biol Chem. 2016 Nov 25; 291(48):25255-25263. Koga T, Yao PL, Goudarzi M, Murray IA, Balandaram G, Gonzalez FJ, Perdew GH, Fornace AJ, Peters JM. PMID: 27765815; PMCID: PMC5122791.
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    275. Identification and characterization of PPARα ligands in the hippocampus. Nat Chem Biol. 2016 Dec; 12(12):1075-1083. Roy A, Kundu M, Jana M, Mishra RK, Yung Y, Luan CH, Gonzalez FJ, Pahan K. PMID: 27748752; PMCID: PMC5110367.
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    276. PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis. J Nutr Biochem. 2017 01; 39:77-85. Hu X, Tanaka N, Guo R, Lu Y, Nakajima T, Gonzalez FJ, Aoyama T. PMID: 27816763; PMCID: PMC6331014.
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    277. Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism. mSystems. 2016 Sep-Oct; 1(5). Zhang L, Xie C, Nichols RG, Chan SH, Jiang C, Hao R, Smith PB, Cai J, Simons MN, Hatzakis E, Maranas CD, Gonzalez FJ, Patterson AD. PMID: 27822554; PMCID: PMC5080402.
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    278. Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans. J Lipid Res. 2016 12; 57(12):2130-2137. Takahashi S, Fukami T, Masuo Y, Brocker CN, Xie C, Krausz KW, Wolf CR, Henderson CJ, Gonzalez FJ. PMID: 27638959; PMCID: PMC5321228.
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    279. An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease. Gastroenterology. 2016 11; 151(5):845-859. Gonzalez FJ, Jiang C, Patterson AD. PMID: 27639801; PMCID: PMC5159222.
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    280. PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate. Can J Physiol Pharmacol. 2017 Feb; 95(2):199-205. Song D, Luo M, Dai M, Bu S, Wang W, Zhang B, Gonzalez FJ, Liu A. PMID: 27918198; PMCID: PMC6334299.
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    281. Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation. Mol Endocrinol. 2016 Oct; 30(10):1070-1080. Hashiguchi T, Arakawa S, Takahashi S, Gonzalez FJ, Sueyoshi T, Negishi M. PMID: 27571290; PMCID: PMC5045495.
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    282. The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4. Biochem Pharmacol. 2016 Nov 01; 119:93-104. Gao X, Xie C, Wang Y, Luo Y, Yagai T, Sun D, Qin X, Krausz KW, Gonzalez FJ. PMID: 27569425; PMCID: PMC5061623.
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    283. Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan. Clin Sci (Lond). 2016 11 01; 130(21):1969-1981. Harada M, Kamijo Y, Nakajima T, Hashimoto K, Yamada Y, Shimojo H, Gonzalez FJ, Aoyama T. PMID: 27496805; PMCID: PMC6331013.
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    284. ISN Forefronts Symposium 2015: Nuclear Receptors and Diabetic Nephropathy. Kidney Int Rep. 2016 Sep; 1(3):177-188. Zheng B, Chen L, Gonzalez FJ. PMID: 28932823; PMCID: PMC5601313.
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    285. Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice. Hepatology. 2016 10; 64(4):1072-85. Xu Y, Li F, Zalzala M, Xu J, Gonzalez FJ, Adorini L, Lee YK, Yin L, Zhang Y. PMID: 27359351; PMCID: PMC5033696.
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    286. Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway. Sci Rep. 2016 07 12; 6:29743. Chen Y, Singh S, Matsumoto A, Manna SK, Abdelmegeed MA, Golla S, Murphy RC, Dong H, Song BJ, Gonzalez FJ, Thompson DC, Vasiliou V. PMID: 27403993; PMCID: PMC4940737.
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    287. Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice. Toxicology. 2016 07 01; 363-364:1-9. Balandaram G, Kramer LR, Kang BH, Murray IA, Perdew GH, Gonzalez FJ, Peters JM. PMID: 27427494; PMCID: PMC5278792.
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    288. Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation. J Pharm Pharmacol. 2016 Sep; 68(9):1203-13. Tan Z, Luo M, Yang J, Cheng Y, Huang J, Lu C, Song D, Ye M, Dai M, Gonzalez FJ, Liu A, Guo B. PMID: 27367057; PMCID: PMC6300992.
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    289. Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity. Arch Toxicol. 2017 Feb; 91(2):897-907. Luo M, Tan Z, Dai M, Song D, Lin J, Xie M, Yang J, Sun L, Wei D, Zhao J, Gonzalez FJ, Liu A. PMID: 27344344; PMCID: PMC6350782.
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    290. Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene. Glycoconj J. 2016 12; 33(6):927-936. Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T. PMID: 27318478; PMCID: PMC6309323.
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    291. Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice. Am J Pathol. 2016 08; 186(8):2204-2219. Thirunavukkarasu S, Khan NS, Song CY, Ghafoor HU, Brand DD, Gonzalez FJ, Malik KU. PMID: 27301358; PMCID: PMC4973656.
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    292. PPARα activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver. Biochem Biophys Res Commun. 2016 08 05; 476(4):293-298. Kim JH, Wahyudi LD, Kim KK, Gonzalez FJ. PMID: 27233605; PMCID: PMC6300979.
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    293. Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos. J Clin Sleep Med. 2016 05 15; 12(5):719-26. Chopra A, Jung M, Kaplan RC, Appel DW, Dinces EA, Dhar S, Zee PC, Gonzalez F, Lee DJ, Ramos AR, Hoffman HJ, Redline S, Cruickshanks KJ, Shah NA. PMID: 26951413; PMCID: PMC4865559.
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    294. Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization. Life Sci. 2016 Jun 15; 155:76-84. Climaco-Arvizu S, Domínguez-Acosta O, Cabañas-Cortés MA, Rodríguez-Sosa M, Gonzalez FJ, Vega L, Elizondo G. PMID: 27153778; PMCID: PMC6300993.
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    295. A lipidomics investigation into the intervention of celastrol in experimental colitis. Mol Biosyst. 2016 04 26; 12(5):1436-44. Wang R, Gu X, Dai W, Ye J, Lu F, Chai Y, Fan G, Gonzalez FJ, Duan G, Qi Y. PMID: 27021137; PMCID: PMC6338340.
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    296. Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells. Anal Bioanal Chem. 2016 Jun; 408(16):4267-73. Yu T, Wang Y, Zhang H, Johnson CH, Jiang Y, Li X, Wu Z, Liu T, Krausz KW, Yu A, Gonzalez FJ, Huang M, Bi H. PMID: 27074779; PMCID: PMC6300981.
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    297. Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev. 2016 06; 25(6):978-86. Haznadar M, Cai Q, Krausz KW, Bowman ED, Margono E, Noro R, Thompson MD, Mathé EA, Munro HM, Steinwandel MD, Gonzalez FJ, Blot WJ, Harris CC. PMID: 27013655; PMCID: PMC4891298.
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    298. Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog. 2017 01; 56(1):163-171. Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer L, Waters KM, Williams DE. PMID: 26990437; PMCID: PMC5457169.
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    299. Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis. Drug Metab Dispos. 2016 May; 44(5):720-31. Yan T, Wang H, Zhao M, Yagai T, Chai Y, Krausz KW, Xie C, Cheng X, Zhang J, Che Y, Li F, Wu Y, Brocker CN, Gonzalez FJ, Wang G, Hao H. PMID: 26965985; PMCID: PMC4851304.
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    300. 6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice. Hypertension. 2016 May; 67(5):916-26. Pingili AK, Thirunavukkarasu S, Kara M, Brand DD, Katsurada A, Majid DS, Navar LG, Gonzalez FJ, Malik KU. PMID: 26928804; PMCID: PMC4833582.
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    301. Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer. Cancer Res. 2016 Mar 15; 76(6):1569-77. Cook JA, Chandramouli GV, Anver MR, Sowers AL, Thetford A, Krausz KW, Gonzalez FJ, Mitchell JB, Patterson AD. PMID: 26880804; PMCID: PMC4794383.
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    302. Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):386-95. Barr RG, Avilés-Santa L, Davis SM, Aldrich TK, Gonzalez F, Henderson AG, Kaplan RC, LaVange L, Liu K, Loredo JS, Mendes ES, Ni A, Ries A, Salathe M, Smith LJ. PMID: 26451874; PMCID: PMC4803083.
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    303. Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis. Gut. 2016 07; 65(7):1186-201. Yang Y, Lin X, Lu X, Luo G, Zeng T, Tang J, Jiang F, Li L, Cui X, Huang W, Hou G, Chen X, Ouyang Q, Tang S, Sun H, Chen L, Gonzalez FJ, Wu M, Cong W, Chen L, Wang H. PMID: 26860770; PMCID: PMC6624432.
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    304. HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling. Cell Metab. 2016 Mar 08; 23(3):505-16. Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM. PMID: 26853750; PMCID: PMC4785079.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    305. Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma. Cancer Lett. 2016 Apr 10; 373(2):234-40. Li L, Chen J, Chen X, Tang J, Guo H, Wang X, Qian J, Luo G, He F, Lu X, Ding Y, Yang Y, Huang W, Hou G, Lin X, Ouyang Q, Li H, Wang R, Jiang F, Pu R, Lu J, Jin M, Tan Y, Gonzalez FJ, Cao G, Wu M, Wen H, Wu T, Jin L, Chen L, Wang H. PMID: 26850373; PMCID: PMC6594104.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    306. PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice. Arch Toxicol. 2016 Dec; 90(12):3061-3071. Harada Y, Tanaka N, Ichikawa M, Kamijo Y, Sugiyama E, Gonzalez FJ, Aoyama T. PMID: 26838045; PMCID: PMC6334304.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    307. Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota. J Proteome Res. 2016 Feb 05; 15(2):563-71. Cai J, Zhang L, Jones RA, Correll JB, Hatzakis E, Smith PB, Gonzalez FJ, Patterson AD. PMID: 26696396; PMCID: PMC4847541.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    308. Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression. Toxicol Appl Pharmacol. 2016 Jan 15; 291:21-7. Fang ZZ, Zhang D, Cao YF, Xie C, Lu D, Sun DX, Tanaka N, Jiang C, Chen Q, Chen Y, Wang H, Gonzalez FJ. PMID: 26706406; PMCID: PMC4718832.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    309. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun. 2015 Dec 15; 6:10166. Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ. PMID: 26670557; PMCID: PMC4682112.
      View in: PubMed   Mentions: 282     Fields:    Translation:HumansAnimals
    310. Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value. Nat Neurosci. 2016 Jan; 19(1):37-9. Eldridge MA, Lerchner W, Saunders RC, Kaneko H, Krausz KW, Gonzalez FJ, Ji B, Higuchi M, Minamimoto T, Richmond BJ. PMID: 26656645; PMCID: PMC4866611.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    311. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension. 2016 Jan; 67(1):206-13. Song CY, Ghafoor K, Ghafoor HU, Khan NS, Thirunavukkarasu S, Jennings BL, Estes AM, Zaidi S, Bridges D, Tso P, Gonzalez FJ, Malik KU. PMID: 26573711; PMCID: PMC4672747.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    312. New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases. Chemosphere. 2016 Feb; 144:1966-72. Liu X, Cao YF, Ran RX, Dong PP, Gonzalez FJ, Wu X, Huang T, Chen JX, Fu ZW, Li RS, Liu YZ, Sun HZ, Fang ZZ. PMID: 26547877; PMCID: PMC6300982.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    313. Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms. Oncotarget. 2015 Nov 03; 6(34):36319-37. Yao PL, Chen LP, Dobrzanski TP, Phillips DA, Zhu B, Kang BH, Gonzalez FJ, Peters JM. PMID: 26431381; PMCID: PMC4742180.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    314. Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver. J Biol Chem. 2015 Dec 25; 290(52):30855-65. Matsuo S, Ogawa M, Muckenthaler MU, Mizui Y, Sasaki S, Fujimura T, Takizawa M, Ariga N, Ozaki H, Sakaguchi M, Gonzalez FJ, Inoue Y. PMID: 26527688; PMCID: PMC4692214.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    315. Establishing the Role of PPARβ/δ in Carcinogenesis. Trends Endocrinol Metab. 2015 Nov; 26(11):595-607. Peters JM, Gonzalez FJ, Müller R. PMID: 26490384; PMCID: PMC4631629.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    316. Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015 Sep 29; 6:8186. Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD. PMID: 26416771; PMCID: PMC4598356.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    317. Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo. Diabetologia. 2015 Dec; 58(12):2832-42. Pillai R, Paglialunga S, Hoang M, Cousteils K, Prentice KJ, Bombardier E, Huang M, Gonzalez FJ, Tupling AR, Wheeler MB, Joseph JW. PMID: 26409461; PMCID: PMC6338330.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    318. Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling. J Biol Chem. 2015 Sep 18; 290(38):23416-31. Yao PL, Chen L, Hess RA, Müller R, Gonzalez FJ, Peters JM. PMID: 26242735; PMCID: PMC4645614.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    319. Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). Toxicology. 2015 Oct 02; 336:99-112. Oshida K, Vasani N, Thomas RS, Applegate D, Gonzalez FJ, Aleksunes LM, Klaassen CD, Corton JC. PMID: 26215100; PMCID: PMC6661527.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    320. Metabolic mapping of A3 adenosine receptor agonist MRS5980. Biochem Pharmacol. 2015 Sep 15; 97(2):215-23. Fang ZZ, Tosh DK, Tanaka N, Wang H, Krausz KW, O'Connor R, Jacobson KA, Gonzalez FJ. PMID: 26212548; PMCID: PMC4581425.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    321. Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor. Exp Dermatol. 2015 Nov; 24(11):835-40. Elentner A, Ortner D, Clausen B, Gonzalez FJ, Fernández-Salguero PM, Schmuth M, Dubrac S. PMID: 26013842; PMCID: PMC6334296.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    322. Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity. J Pharmacol Exp Ther. 2015 Sep; 354(3):459-70. Spruiell K, Gyamfi AA, Yeyeodu ST, Richardson RM, Gonzalez FJ, Gyamfi MA. PMID: 26159875; PMCID: PMC4538875.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    323. Hearing Impairment Prevalence and Associated Risk Factors in the Hispanic Community Health Study/Study of Latinos. JAMA Otolaryngol Head Neck Surg. 2015 Jul; 141(7):641-8. Cruickshanks KJ, Dhar S, Dinces E, Fifer RC, Gonzalez F, Heiss G, Hoffman HJ, Lee DJ, Newhoff M, Tocci L, Torre P, Tweed TS. PMID: 26021283; PMCID: PMC4506256.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    324. HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice. Cell Metab. 2015 Aug 04; 22(2):253-65. Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K. PMID: 26118928; PMCID: PMC4526399.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    325. Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. Gastroenterology. 2015 Oct; 149(4):1030-41.e6. Xu MJ, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara T, Mukhopadhyay P, Kimura S, Pacher P, Gonzalez FJ, Bataller R, Gao B. PMID: 26099526; PMCID: PMC4584194.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    326. Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis. Phytother Res. 2015 Oct; 29(10):1658-64. Song JH, Cui L, An LB, Li WT, Fang ZZ, Zhang YY, Dong PP, Wu X, Wang LX, Gonzalez FJ, Sun XY, Zhao DW. PMID: 26084208; PMCID: PMC6594156.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    327. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8445-50. Corbett GT, Gonzalez FJ, Pahan K. PMID: 26080426; PMCID: PMC4500265.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    328. St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling. Cancer Prev Res (Phila). 2015 Sep; 8(9):786-95. Manna SK, Golla S, Golla JP, Tanaka N, Cai Y, Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez FJ. PMID: 26069204; PMCID: PMC4584416.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    329. Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. Biochim Biophys Acta. 2015 Aug; 1849(8):919-29. Cicchini C, de Nonno V, Battistelli C, Cozzolino AM, De Santis Puzzonia M, Ciafrè SA, Brocker C, Gonzalez FJ, Amicone L, Tripodi M. PMID: 26003733; PMCID: PMC6319628.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    330. GC-MS metabolomics on PPARα-dependent exacerbation of colitis. Mol Biosyst. 2015 May; 11(5):1329-37. Gu X, Song Y, Chai Y, Lu F, Gonzalez FJ, Fan G, Qi Y. PMID: 25790429; PMCID: PMC6334306.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    331. 6β-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice. Hypertension. 2015 Jun; 65(6):1279-87. Pingili AK, Kara M, Khan NS, Estes AM, Lin Z, Li W, Gonzalez FJ, Malik KU. PMID: 25870196; PMCID: PMC4433413.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    332. Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity. Expert Opin Drug Metab Toxicol. 2015 Jun; 11(6):869-81. Gonzalez FJ, Fang ZZ, Ma X. PMID: 25836352; PMCID: PMC4706076.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    333. Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. Environ Health Perspect. 2015 Jul; 123(7):679-88. Zhang L, Nichols RG, Correll J, Murray IA, Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD. PMID: 25768209; PMCID: PMC4492271.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    334. Modulation of colon cancer by nutmeg. J Proteome Res. 2015 Apr 03; 14(4):1937-46. Li F, Yang XW, Krausz KW, Nichols RG, Xu W, Patterson AD, Gonzalez FJ. PMID: 25712450; PMCID: PMC6334305.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    335. Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases. Chem Biol Interact. 2015 Apr 25; 231:90-7. Guo B, Fang Z, Yang L, Xiao L, Xia Y, Gonzalez FJ, Zhu L, Cao Y, Ge G, Yang L, Sun H. PMID: 25765239; PMCID: PMC6300978.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    336. Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders. J Biol Chem. 2015 Apr 17; 290(16):10309-24. Ghosh A, Jana M, Modi K, Gonzalez FJ, Sims KB, Berry-Kravis E, Pahan K. PMID: 25750174; PMCID: PMC4400343.
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    337. Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity. J Hepatol. 2015 Jun; 62(6):1234-6. Gonzalez FJ, Jiang C, Bisson WH, Patterson AD. PMID: 25747705; PMCID: PMC6346267.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    338. Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta. 2015 Jul; 1852(7):1242-52. Tanaka N, Takahashi S, Zhang Y, Krausz KW, Smith PB, Patterson AD, Gonzalez FJ. PMID: 25736301; PMCID: PMC4433820.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    339. Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy. BBA Clin. 2015 Jun; 3:168-74. Nagaya T, Tanaka N, Kimura T, Kitabatake H, Fujimori N, Komatsu M, Horiuchi A, Yamaura T, Umemura T, Sano K, Gonzalez FJ, Aoyama T, Tanaka E. PMID: 26674248; PMCID: PMC4661550.
      View in: PubMed   Mentions: 19  
    340. Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice. Am J Physiol Renal Physiol. 2015 May 01; 308(9):F981-92. Jennings BL, Moore JA, Pingili AK, Estes AM, Fang XR, Kanu A, Gonzalez FJ, Malik KU. PMID: 25694484; PMCID: PMC4420992.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    341. Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism. Lab Invest. 2015 May; 95(5):515-24. Teranishi Y, Matsubara T, Krausz KW, Le TT, Gonzalez FJ, Yoshizato K, Ikeda K, Kawada N. PMID: 25686096; PMCID: PMC6331008.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    342. Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage. Toxicol Ind Health. 2016 Sep; 32(9):1589-97. Yanagiba Y, Suzuki T, Suda M, Hojo R, Gonzalez FJ, Nakajima T, Wang RS. PMID: 25681370; PMCID: PMC6300984.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    343. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59. Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B. PMID: 25680282; PMCID: PMC4418801.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    344. Application of mass spectrometry-based metabolomics in identification of early noninvasive biomarkers of alcohol-induced liver disease using mouse model. Adv Exp Med Biol. 2015; 815:217-38. Manna SK, Thompson MD, Gonzalez FJ. PMID: 25427910; PMCID: PMC6335647.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    345. Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARα(PAC) mice due to dysregulated bile acid synthesis. Oncotarget. 2015; 6(12):9686-700. Liu HX, Hu Y, French SW, Gonzalez FJ, Wan YJ. PMID: 25991671; PMCID: PMC4496390.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    346. Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention. Curr Pharmacol Rep. 2015; 1(2):121-128. Peters JM, Yao PL, Gonzalez FJ. PMID: 26000234; PMCID: PMC4433882.
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    347. Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine. Drug Metab Dispos. 2015 Mar; 43(3):317-24. Fan X, Chen P, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Qu A, Gonzalez FJ, Huang M, Bi H. PMID: 25534769; PMCID: PMC6067383.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    348. Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat. Metabolomics. 2015 Oct 01; 11(5):1082-1094. Mak TD, Tyburski JB, Krausz KW, Kalinich JF, Gonzalez FJ, Fornace AJ. PMID: 26557048; PMCID: PMC4635442.
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    349. Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα. Biochim Biophys Acta. 2015 Mar; 1852(3):473-81. Komatsu M, Kimura T, Yazaki M, Tanaka N, Yang Y, Nakajima T, Horiuchi A, Fang ZZ, Joshita S, Matsumoto A, Umemura T, Tanaka E, Gonzalez FJ, Ikeda S, Aoyama T. PMID: 25533124; PMCID: PMC6371055.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    350. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest. 2015 Jan; 125(1):386-402. Jiang C, Xie C, Li F, Zhang L, Nichols RG, Krausz KW, Cai J, Qi Y, Fang ZZ, Takahashi S, Tanaka N, Desai D, Amin SG, Albert I, Patterson AD, Gonzalez FJ. PMID: 25500885; PMCID: PMC4382255.
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    351. Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice. J Biol Chem. 2015 Jan 30; 290(5):3092-105. Tanaka N, Takahashi S, Matsubara T, Jiang C, Sakamoto W, Chanturiya T, Teng R, Gavrilova O, Gonzalez FJ. PMID: 25477509; PMCID: PMC4317012.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    352. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015 Jan; 143(1):107-15. Jiang Y, Fan X, Wang Y, Chen P, Zeng H, Tan H, Gonzalez FJ, Huang M, Bi H. PMID: 25319358; PMCID: PMC4334815.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    353. New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production. Food Chem. 2015 Apr 15; 173:231-7. Cao GY, Xu W, Yang XW, Gonzalez FJ, Li F. PMID: 25466017; PMCID: PMC6338084.
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    354. Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J Pharmacol Exp Ther. 2014 Dec; 351(3):559-67. Cheng J, Fang ZZ, Nagaoka K, Okamoto M, Qu A, Tanaka N, Kimura S, Gonzalez FJ. PMID: 25277138; PMCID: PMC4244584.
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    355. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014 Nov 05; 223:80-6. Liu A, Tanaka N, Sun L, Guo B, Kim JH, Krausz KW, Fang Z, Jiang C, Yang J, Gonzalez FJ. PMID: 25265579; PMCID: PMC4376644.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    356. Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. Drug Metab Dispos. 2014 Dec; 42(12):1982-90. Fan X, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Chen P, Qu A, Gonzalez FJ, Huang M, Bi H. PMID: 25217484; PMCID: PMC6067381.
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    357. Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver. J Lipid Res. 2014 Nov; 55(11):2309-19. Beyoglu D, Krausz KW, Martin J, Maurhofer O, Dorow J, Ceglarek U, Gonzalez FJ, Dufour JF, Idle JR. PMID: 25193995; PMCID: PMC4617133.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    358. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun. 2014 Sep 03; 5:4573. Zhou X, Cao L, Jiang C, Xie Y, Cheng X, Krausz KW, Qi Y, Sun L, Shah YM, Gonzalez FJ, Wang G, Hao H. PMID: 25183423; PMCID: PMC4164778.
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    359. Improved drug therapy: triangulating phenomics with genomics and metabolomics. Hum Genomics. 2014 Sep 01; 8:16. Monte AA, Brocker C, Nebert DW, Gonzalez FJ, Thompson DC, Vasiliou V. PMID: 25181945; PMCID: PMC4445687.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    360. Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta. 2014 Nov; 1841(11):1596-607. Tanaka N, Takahashi S, Fang ZZ, Matsubara T, Krausz KW, Qu A, Gonzalez FJ. PMID: 25178843; PMCID: PMC4188754.
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    361. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis. 2014 Oct; 35(10):2264-72. Bi HC, Pan YZ, Qiu JX, Krausz KW, Li F, Johnson CH, Jiang CT, Gonzalez FJ, Yu AM. PMID: 25115443; PMCID: PMC4178474.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    362. PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 01; 307(5):G564-73. Qi Y, Jiang C, Tanaka N, Krausz KW, Brocker CN, Fang ZZ, Bredell BX, Shah YM, Gonzalez FJ. PMID: 25035112; PMCID: PMC4154119.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    363. PPARβ/δ activation of CD300a controls intestinal immunity. Sci Rep. 2014 Jun 24; 4:5412. Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J. PMID: 24958459; PMCID: PMC4067692.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    364. The nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress. J Biol Chem. 2014 Jul 18; 289(29):20102-19. Zhu B, Ferry CH, Markell LK, Blazanin N, Glick AB, Gonzalez FJ, Peters JM. PMID: 24898257; PMCID: PMC4106326.
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    365. Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation. Mol Cell Biol. 2014 Aug; 34(16):3013-23. Xie L, Xue X, Taylor M, Ramakrishnan SK, Nagaoka K, Hao C, Gonzalez FJ, Shah YM. PMID: 24891620; PMCID: PMC4135598.
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    366. Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice. FEBS Lett. 2014 Jun 27; 588(14):2277-81. Matsusue K, Aibara D, Hayafuchi R, Matsuo K, Takiguchi S, Gonzalez FJ, Yamano S. PMID: 24857376; PMCID: PMC6301023.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    367. Metabolic profiling of praziquantel enantiomers. Biochem Pharmacol. 2014 Jul 15; 90(2):166-78. Wang H, Fang ZZ, Zheng Y, Zhou K, Hu C, Krausz KW, Sun D, Idle JR, Gonzalez FJ. PMID: 24821110; PMCID: PMC4168258.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    368. Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys Acta. 2015 Jan; 1851(1):19-29. Qi Y, Jiang C, Cheng J, Krausz KW, Li T, Ferrell JM, Gonzalez FJ, Chiang JY. PMID: 24796972; PMCID: PMC4219936.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    369. Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice. Hypertension. 2014 Jul; 64(1):134-40. Jennings BL, George LW, Pingili AK, Khan NS, Estes AM, Fang XR, Gonzalez FJ, Malik KU. PMID: 24777982; PMCID: PMC4065791.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    370. Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer. Cancer Res. 2014 Jun 15; 74(12):3259-70. Mathé EA, Patterson AD, Haznadar M, Manna SK, Krausz KW, Bowman ED, Shields PG, Idle JR, Smith PB, Anami K, Kazandjian DG, Hatzakis E, Gonzalez FJ, Harris CC. PMID: 24736543; PMCID: PMC4100625.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    371. Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice. Biochem Pharmacol. 2014 Jun 01; 89(3):399-412. Spruiell K, Jones DZ, Cullen JM, Awumey EM, Gonzalez FJ, Gyamfi MA. PMID: 24721462; PMCID: PMC4057797.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    372. Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity. J Proteome Res. 2014 May 02; 13(5):2679-87. Li F, Jiang C, Larsen MC, Bushkofsky J, Krausz KW, Wang T, Jefcoate CR, Gonzalez FJ. PMID: 24684199; PMCID: PMC4018097.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    373. LC-MS-based metabolomics: an update. Arch Toxicol. 2014 Aug; 88(8):1491-502. Fang ZZ, Gonzalez FJ. PMID: 24710571; PMCID: PMC6310611.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    374. In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract. Br J Pharmacol. 2014 Apr; 171(7):1735-46. Fang ZZ, Krausz KW, Nagaoka K, Tanaka N, Gowda K, Amin SG, Perdew GH, Gonzalez FJ. PMID: 24417285; PMCID: PMC3966752.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    375. Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in keratinocytes. Carcinogenesis. 2014 Jul; 35(7):1602-12. Borland MG, Krishnan P, Lee C, Albrecht PP, Shan W, Bility MT, Marcus CB, Lin JM, Amin S, Gonzalez FJ, Perdew GH, Peters JM. PMID: 24639079; PMCID: PMC4076811.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    376. Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7. Toxicol Appl Pharmacol. 2014 May 15; 277(1):86-94. Ma HY, Sun DX, Cao YF, Ai CZ, Qu YQ, Hu CM, Jiang C, Dong PP, Sun XY, Hong M, Tanaka N, Gonzalez FJ, Ma XC, Fang ZZ. PMID: 24631340; PMCID: PMC6335651.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    377. Potential role of the vitamin D receptor in control of cholesterol levels. Gastroenterology. 2014 Apr; 146(4):899-902. Gonzalez FJ, Moschetta A. PMID: 24566107; PMCID: PMC6350777.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    378. Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo. Am J Physiol Endocrinol Metab. 2014 Apr 01; 306(7):E824-37. Bonzo JA, Brocker C, Jiang C, Wang RH, Deng CX, Gonzalez FJ. PMID: 24496310; PMCID: PMC4116399.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    379. Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity. Mol Cancer Ther. 2014 Apr; 13(4):1008-17. Yao PL, Morales JL, Zhu B, Kang BH, Gonzalez FJ, Peters JM. PMID: 24464939; PMCID: PMC3981956.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    380. Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology. 2014 May; 146(5):1313-24. Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, Matsubara T, Bowman ED, Fearon ER, Harris CC, Shah YM, Gonzalez FJ. PMID: 24440673; PMCID: PMC3992178.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    381. Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis. Mol Cell Biol. 2014 Apr; 34(7):1208-20. Ramakrishnan SK, Taylor M, Qu A, Ahn SH, Suresh MV, Raghavendran K, Gonzalez FJ, Shah YM. PMID: 24421394; PMCID: PMC3993569.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    382. Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes. Drug Metab Dispos. 2014 Apr; 42(4):492-9. Lee JK, Chung HJ, Fischer L, Fischer J, Gonzalez FJ, Jeong H. PMID: 24408518; PMCID: PMC3965907.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    383. Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014; 9(1):e84583. Ciappio ED, Krausz KW, Rochman M, Furusawa T, Bonzo JA, Tessarollo L, Gonzalez FJ, Bustin M. PMID: 24392144; PMCID: PMC3879345.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    384. Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3. Hepatology. 2014 Feb; 59(2):695-704. Kim JH, Qu A, Reddy JK, Gao B, Gonzalez FJ. PMID: 23939942; PMCID: PMC3880633.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    385. Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice. J Lipid Res. 2014 Mar; 55(3):455-65. Cheng J, Fang ZZ, Kim JH, Krausz KW, Tanaka N, Chiang JY, Gonzalez FJ. PMID: 24343899; PMCID: PMC3934730.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    386. Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. J Biol Chem. 2014 Feb 07; 289(6):3105-13. Koh KH, Pan X, Shen HW, Arnold SL, Yu AM, Gonzalez FJ, Isoherranen N, Jeong H. PMID: 24318876; PMCID: PMC3916516.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    387. MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse. RNA Biol. 2013 Dec; 10(12):1807-14. Feuermann Y, Kang K, Gavrilova O, Haetscher N, Jang SJ, Yoo KH, Jiang C, Gonzalez FJ, Robinson GW, Hennighausen L. PMID: 24356587; PMCID: PMC3917983.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    388. Role of Myc in hepatocellular proliferation and hepatocarcinogenesis. J Hepatol. 2014 Feb; 60(2):331-8. Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ. PMID: 24096051; PMCID: PMC3909877.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    389. CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. Free Radic Biol Med. 2013 Dec; 65:1238-1245. Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ. PMID: 24064383; PMCID: PMC3859835.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    390. Role of PPARα and HNF4α in stress-mediated alterations in lipid homeostasis. PLoS One. 2013; 8(8):e70675. Konstandi M, Shah YM, Matsubara T, Gonzalez FJ. PMID: 23967086; PMCID: PMC3743822.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    391. The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase. J Biol Chem. 2013 Sep 27; 288(39):27898-911. Viswakarma N, Jia Y, Bai L, Gao Q, Lin B, Zhang X, Misra P, Rana A, Jain S, Gonzalez FJ, Zhu YJ, Thimmapaya B, Reddy JK. PMID: 23943624; PMCID: PMC3784705.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    392. Global metabolomics reveals urinary biomarkers of breast cancer in a mcf-7 xenograft mouse model. Metabolites. 2013 Aug 07; 3(3):658-72. Johnson CH, Manna SK, Krausz KW, Bonzo JA, Divelbiss RD, Hollingshead MG, Gonzalez FJ. PMID: 24958144; PMCID: PMC3901288.
      View in: PubMed   Mentions: 11  
    393. Cholestasis induces reversible accumulation of periplakin in mouse liver. BMC Gastroenterol. 2013 Jul 13; 13:116. Ito S, Satoh J, Matsubara T, Shah YM, Ahn SH, Anderson CR, Shan W, Peters JM, Gonzalez FJ. PMID: 23849208; PMCID: PMC3716950.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    394. Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping. Toxicol Sci. 2013 Sep; 135(1):37-47. Cheng J, Chen C, Kristopher KW, Manna SK, Scerba M, Friedman FK, Luecke H, Idle JR, Gonzalez FJ. PMID: 23811823; PMCID: PMC3748767.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    395. Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. Chem Res Toxicol. 2013 Jul 15; 26(7):1088-96. Patterson AD, Carlson BA, Li F, Bonzo JA, Yoo MH, Krausz KW, Conrad M, Chen C, Gonzalez FJ, Hatfield DL. PMID: 23697945; PMCID: PMC6334300.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    396. Metabolomics reveals that tumor xenografts induce liver dysfunction. Mol Cell Proteomics. 2013 Aug; 12(8):2126-35. Li F, Patterson AD, Krausz KW, Jiang C, Bi H, Sowers AL, Cook JA, Mitchell JB, Gonzalez FJ. PMID: 23637421; PMCID: PMC3734574.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    397. Potential role of CYP2D6 in the central nervous system. Xenobiotica. 2013 Nov; 43(11):973-84. Cheng J, Zhen Y, Miksys S, Beyoglu D, Krausz KW, Tyndale RF, Yu A, Idle JR, Gonzalez FJ. PMID: 23614566; PMCID: PMC3750078.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    398. Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair. J Proteome Res. 2013 May 03; 12(5):2269-81. Manna SK, Krausz KW, Bonzo JA, Idle JR, Gonzalez FJ. PMID: 23586774; PMCID: PMC3678303.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    399. Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. Arch Toxicol. 2013 Nov; 87(11):1975-1987. Fang ZZ, Krausz KW, Tanaka N, Li F, Qu A, Idle JR, Gonzalez FJ. PMID: 23575800; PMCID: PMC6338077.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    400. Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B cells via peroxisome proliferator-activated receptor α. J Immunol. 2013 Mar 15; 190(6):2575-84. Wejksza K, Lee-Chang C, Bodogai M, Bonzo J, Gonzalez FJ, Lehrmann E, Becker K, Biragyn A. PMID: 23408836; PMCID: PMC3594535.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    401. Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity. Evid Based Complement Alternat Med. 2013; 2013:985257. Bi H, Li F, Krausz KW, Qu A, Johnson CH, Gonzalez FJ. PMID: 23431354; PMCID: PMC3575671.
      View in: PubMed   Mentions: 19  
    402. Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology. J Proteome Res. 2013 Mar 01; 12(3):1369-76. Li F, Pang X, Krausz KW, Jiang C, Chen C, Cook JA, Krishna MC, Mitchell JB, Gonzalez FJ, Patterson AD. PMID: 23301521; PMCID: PMC3594779.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    403. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat Commun. 2013; 4:2384. Li F, Jiang C, Krausz KW, Li Y, Albert I, Hao H, Fabre KM, Mitchell JB, Patterson AD, Gonzalez FJ. PMID: 24064762; PMCID: PMC6595219.
      View in: PubMed   Mentions: 359     Fields:    Translation:AnimalsCells
    404. Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver. Biol Pharm Bull. 2013; 36(11):1766-72. Aibara D, Matsusue K, Matsuo K, Takiguchi S, Gonzalez FJ, Yamano S. PMID: 24189421; PMCID: PMC7667495.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    405. Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes. J Biol Chem. 2013 Feb 08; 288(6):3844-57. Jiang C, Kim JH, Li F, Qu A, Gavrilova O, Shah YM, Gonzalez FJ. PMID: 23255598; PMCID: PMC3567639.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    406. Protective role of vascular smooth muscle cell PPARγ in angiotensin II-induced vascular disease. Cardiovasc Res. 2013 Mar 01; 97(3):562-70. Marchesi C, Rehman A, Rautureau Y, Kasal DA, Briet M, Leibowitz A, Simeone SM, Ebrahimian T, Neves MF, Offermanns S, Gonzalez FJ, Paradis P, Schiffrin EL. PMID: 23250918.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    407. Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier. PLoS Genet. 2012; 8(11):e1003053. Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG. PMID: 23209428; PMCID: PMC3510057.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    408. Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice. Drug Metab Dispos. 2013 Feb; 41(2):406-13. Johnson CH, Bonzo JA, Cheng J, Krausz KW, Kang DW, Luecke H, Idle JR, Gonzalez FJ. PMID: 23160821; PMCID: PMC3558860.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    409. CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid. Toxicol Appl Pharmacol. 2013 Jan 15; 266(2):245-53. Cheng J, Krausz KW, Li F, Ma X, Gonzalez FJ. PMID: 23142471; PMCID: PMC3661416.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    410. Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. Cell Metab. 2012 Nov 07; 16(5):634-44. Matsubara T, Tanaka N, Krausz KW, Manna SK, Kang DW, Anderson ER, Luecke H, Patterson AD, Shah YM, Gonzalez FJ. PMID: 23140643; PMCID: PMC3496181.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    411. Metabolic map and bioactivation of the anti-tumour drug noscapine. Br J Pharmacol. 2012 Nov; 167(6):1271-86. Fang ZZ, Krausz KW, Li F, Cheng J, Tanaka N, Gonzalez FJ. PMID: 22671862; PMCID: PMC3504993.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    412. Reply:. Hepatology. 2012 Nov; 56(5):2009. Tanaka N, Gonzalez FJ. PMID: 23115012; PMCID: PMC4260325.
      View in: PubMed   Mentions: 1     Fields:    
    413. Reply to Bile acids in Non-Alcoholic Steato-Hepatitis: inserting nuclear receptors into the circle. Hepatology. 2012 Nov; 56(5):2009. Tanaka N, Gonzalez FJ. PMID: 25505811.
      View in: PubMed   Mentions: 1     Fields:    
    414. TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res. 2012 Dec; 53(12):2698-707. Matsubara T, Tanaka N, Sato M, Kang DW, Krausz KW, Flanders KC, Ikeda K, Luecke H, Wakefield LM, Gonzalez FJ. PMID: 23034213; PMCID: PMC3494264.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    415. Implication of intestinal VDR deficiency in inflammatory bowel disease. Biochim Biophys Acta. 2013 Jan; 1830(1):2118-28. Kim JH, Yamaori S, Tanabe T, Johnson CH, Krausz KW, Kato S, Gonzalez FJ. PMID: 23041070; PMCID: PMC3508150.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    416. Nuclear receptor control of enterohepatic circulation. Compr Physiol. 2012 Oct; 2(4):2811-28. Gonzalez FJ. PMID: 23720266; PMCID: PMC6608752.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    417. Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics. Radiat Res. 2012 Oct; 178(4):328-40. Johnson CH, Patterson AD, Krausz KW, Kalinich JF, Tyburski JB, Kang DW, Luecke H, Gonzalez FJ, Blakely WF, Idle JR. PMID: 22954391; PMCID: PMC3498937.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsPHPublic Health
    418. Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics. Am J Clin Nutr. 2012 Oct; 96(4):818-30. Johnson CH, Slanar O, Krausz KW, Kang DW, Patterson AD, Kim JH, Luecke H, Gonzalez FJ, Idle JR. PMID: 22952181; PMCID: PMC3441109.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    419. Challenges and opportunities of metabolomics. J Cell Physiol. 2012 Aug; 227(8):2975-81. Johnson CH, Gonzalez FJ. PMID: 22034100; PMCID: PMC6309313.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimals
    420. Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. Toxicol Sci. 2012 Oct; 129(2):456-68. Cheng J, Krausz KW, Tanaka N, Gonzalez FJ. PMID: 22790967; PMCID: PMC3491956.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    421. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10504-9. Sarkar K, Cai Z, Gupta R, Parajuli N, Fox-Talbot K, Darshan MS, Gonzalez FJ, Semenza GL. PMID: 22699503; PMCID: PMC3387090.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    422. Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Hepatology. 2012 Jul; 56(1):281-90. Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ. PMID: 22318764; PMCID: PMC3378765.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    423. Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology. 2012 Jul; 56(1):118-29. Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ. PMID: 22290395; PMCID: PMC6371056.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    424. Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis. J Lipid Res. 2012 Aug; 53(8):1625-35. Li F, Patterson AD, Krausz KW, Tanaka N, Gonzalez FJ. PMID: 22665165; PMCID: PMC3540854.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    425. Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol. 2012 Oct; 57(4):860-6. Abdelmegeed MA, Banerjee A, Yoo SH, Jang S, Gonzalez FJ, Song BJ. PMID: 22668639; PMCID: PMC3445664.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    426. Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα. PLoS One. 2012; 7(6):e38104. Safdar H, Cheung KL, Vos HL, Gonzalez FJ, Reitsma PH, Inoue Y, van Vlijmen BJ. PMID: 22675511; PMCID: PMC3365905.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    427. Pregnane X receptor as a target for treatment of inflammatory bowel disorders. Trends Pharmacol Sci. 2012 Jun; 33(6):323-30. Cheng J, Shah YM, Gonzalez FJ. PMID: 22609277; PMCID: PMC3368991.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    428. FXR signaling in the enterohepatic system. Mol Cell Endocrinol. 2013 Apr 10; 368(1-2):17-29. Matsubara T, Li F, Gonzalez FJ. PMID: 22609541; PMCID: PMC3491147.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    429. Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition. Diabetes. 2012 Jun; 61(6):1479-89. Düfer M, Hörth K, Wagner R, Schittenhelm B, Prowald S, Wagner TF, Oberwinkler J, Lukowski R, Gonzalez FJ, Krippeit-Drews P, Drews G. PMID: 22492528; PMCID: PMC3357280.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    430. Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochem Pharmacol. 2012 May 15; 83(10):1435-44. Li F, Patterson AD, Krausz KW, Dick B, Frey FJ, Gonzalez FJ, Idle JR. PMID: 22387617; PMCID: PMC3665348.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    431. Expression and regulation of human fetal-specific CYP3A7 in mice. Endocrinology. 2012 Mar; 153(3):1453-63. Pang XY, Cheng J, Kim JH, Matsubara T, Krausz KW, Gonzalez FJ. PMID: 22253426; PMCID: PMC3281537.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    432. Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice. J Biol Chem. 2012 Mar 02; 287(10):7345-56. Bonzo JA, Ferry CH, Matsubara T, Kim JH, Gonzalez FJ. PMID: 22241473; PMCID: PMC3293558.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    433. Disruption of endothelial peroxisome proliferator-activated receptor γ accelerates diet-induced atherogenesis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):65-73. Qu A, Shah YM, Manna SK, Gonzalez FJ. PMID: 22015658; PMCID: PMC3649072.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    434. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output. Hepatology. 2011 Oct; 54(4):1303-12. Baghdasaryan A, Claudel T, Gumhold J, Silbert D, Adorini L, Roda A, Vecchiotti S, Gonzalez FJ, Schoonjans K, Strazzabosco M, Fickert P, Trauner M. PMID: 22006858; PMCID: PMC3744065.
      View in: PubMed   Mentions: 91     Fields:    Translation:Animals
    435. Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. Cancer Res. 2011 Nov 01; 71(21):6590-600. Patterson AD, Maurhofer O, Beyoglu D, Lanz C, Krausz KW, Pabst T, Gonzalez FJ, Dufour JF, Idle JR. PMID: 21900402; PMCID: PMC3206149.
      View in: PubMed   Mentions: 128     Fields:    Translation:Humans
    436. Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes. 2011 Oct; 60(10):2484-95. Jiang C, Qu A, Matsubara T, Chanturiya T, Jou W, Gavrilova O, Shah YM, Gonzalez FJ. PMID: 21873554; PMCID: PMC3178277.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    437. Xenobiotic metabolomics: major impact on the metabolome. Annu Rev Pharmacol Toxicol. 2012; 52:37-56. Johnson CH, Patterson AD, Idle JR, Gonzalez FJ. PMID: 21819238; PMCID: PMC6300990.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimals
    438. Farnesoid X receptor represses hepatic human APOA gene expression. J Clin Invest. 2011 Sep; 121(9):3724-34. Chennamsetty I, Claudel T, Kostner KM, Baghdasaryan A, Kratky D, Levak-Frank S, Frank S, Gonzalez FJ, Trauner M, Kostner GM. PMID: 21804189; PMCID: PMC3163948.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    439. UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J Proteome Res. 2011 Sep 02; 10(9):4120-33. Manna SK, Patterson AD, Yang Q, Krausz KW, Idle JR, Fornace AJ, Gonzalez FJ. PMID: 21749142; PMCID: PMC3170755.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    440. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol. 2011 Jul; 9(7):e1001112. Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D. PMID: 21814490; PMCID: PMC3144184.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    441. Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis. J Biol Chem. 2011 Aug 26; 286(34):29635-43. Zhang Y, Bonzo JA, Gonzalez FJ, Wang L. PMID: 21725089; PMCID: PMC3191004.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    442. Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology. 2011 Aug; 54(2):472-83. Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, Shah YM. PMID: 21538443; PMCID: PMC3145012.
      View in: PubMed   Mentions: 104     Fields:    Translation:Animals
    443. Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα. Toxicol Lett. 2011 Sep 10; 205(3):265-72. Li Y, Ramdhan DH, Naito H, Yamagishi N, Ito Y, Hayashi Y, Yanagiba Y, Okamura A, Tamada H, Gonzalez FJ, Nakajima T. PMID: 21712084; PMCID: PMC6661110.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    444. Pregnane X receptor- and CYP3A4-humanized mouse models and their applications. Br J Pharmacol. 2011 Jun; 163(3):461-8. Cheng J, Ma X, Gonzalez FJ. PMID: 21091656; PMCID: PMC3101609.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    445. The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α. Hepatology. 2011 Jun; 53(6):2063-74. Santangelo L, Marchetti A, Cicchini C, Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T, Amicone L, Tripodi M. PMID: 21384409; PMCID: PMC6624426.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    446. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes. 2011 Jul; 60(7):1861-71. Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, Dumont J, Bouchaert E, van Dijk TH, Lucas A, Dorchies E, Daoudi M, Lestavel S, Gonzalez FJ, Oresic M, Cariou B, Kuipers F, Caron S, Staels B. PMID: 21593203; PMCID: PMC3121443.
      View in: PubMed   Mentions: 173     Fields:    Translation:Animals
    447. Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J Biol Chem. 2011 Jun 03; 286(22):19511-22. Patterson AD, Bonzo JA, Li F, Krausz KW, Eichler GS, Aslam S, Tigno X, Weinstein JN, Hansen BC, Idle JR, Gonzalez FJ. PMID: 21487016; PMCID: PMC3103330.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    448. Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice. Hepatology. 2011 Apr; 53(4):1282-93. Matsubara T, Tanaka N, Patterson AD, Cho JY, Krausz KW, Gonzalez FJ. PMID: 21480330; PMCID: PMC3077083.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    449. Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011 Jun; 140(7):2044-55. Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ, Shah YM. PMID: 21419768; PMCID: PMC3109109.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    450. PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. J Nutr. 2011 Apr 01; 141(4):603-10. Abdelmegeed MA, Yoo SH, Henderson LE, Gonzalez FJ, Woodcroft KJ, Song BJ. PMID: 21346097; PMCID: PMC3056578.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    451. A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol. 2011 Apr 15; 81(8):1043-53. Li F, Patterson AD, Höfer CC, Krausz KW, Gonzalez FJ, Idle JR. PMID: 21300029; PMCID: PMC6309239.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    452. Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats. Radiat Res. 2011 Apr; 175(4):473-84. Johnson CH, Patterson AD, Krausz KW, Lanz C, Kang DW, Luecke H, Gonzalez FJ, Idle JR. PMID: 21309707; PMCID: PMC3089756.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    453. Pregnane X receptor-mediated induction of Cyp3a by black cohosh. Xenobiotica. 2011 Feb; 41(2):112-23. Pang X, Cheng J, Krausz KW, Guo DA, Gonzalez FJ. PMID: 20979450; PMCID: PMC3019262.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    454. Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo. Mol Endocrinol. 2010 Dec; 24(12):2343-55. Bonzo JA, Patterson AD, Krausz KW, Gonzalez FJ. PMID: 20943816; PMCID: PMC2999475.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    455. Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicol Sci. 2010 Dec; 118(2):380-90. Lu H, Gonzalez FJ, Klaassen C. PMID: 20935164; PMCID: PMC2984525.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    456. PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells. Toxicol Sci. 2010 Dec; 118(2):404-10. Qu A, Shah YM, Matsubara T, Yang Q, Gonzalez FJ. PMID: 20813756; PMCID: PMC2984533.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    457. Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model. Diabetes. 2010 Nov; 59(11):2916-27. Wang XX, Jiang T, Shen Y, Caldas Y, Miyazaki-Anzai S, Santamaria H, Urbanek C, Solis N, Scherzer P, Lewis L, Gonzalez FJ, Adorini L, Pruzanski M, Kopp JB, Verlander JW, Levi M. PMID: 20699418; PMCID: PMC2963551.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    458. Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. J Proteome Res. 2010 Aug 06; 9(8):4176-88. Manna SK, Patterson AD, Yang Q, Krausz KW, Li H, Idle JR, Fornace AJ, Gonzalez FJ. PMID: 20540569; PMCID: PMC2917755.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    459. Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice. Biochem Pharmacol. 2010 Nov 15; 80(10):1601-12. Tanaka N, Zhang X, Sugiyama E, Kono H, Horiuchi A, Nakajima T, Kanbe H, Tanaka E, Gonzalez FJ, Aoyama T. PMID: 20691165; PMCID: PMC6338080.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    460. High density lipoprotein turnover is dependent on peroxisome proliferator-activated receptor α in mice. J Atheroscler Thromb. 2010 Nov 27; 17(11):1149-59. Akita N, Tsujita M, Yokota T, Gonzalez FJ, Ohte N, Kimura G, Yokoyama S. PMID: 20668363.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    461. Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. J Pharmacol Exp Ther. 2010 Oct; 335(1):32-41. Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ. PMID: 20627999; PMCID: PMC2957776.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    462. Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol. 2010 Oct 01; 80(7):1063-74. Li F, Patterson AD, Höfer CC, Krausz KW, Gonzalez FJ, Idle JR. PMID: 20541539; PMCID: PMC2941803.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    463. Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice. Lab Invest. 2010 Oct; 90(10):1457-67. Stroeve JH, Brufau G, Stellaard F, Gonzalez FJ, Staels B, Kuipers F. PMID: 20531290; PMCID: PMC6643294.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    464. Xenobiotic metabolism: a view through the metabolometer. Chem Res Toxicol. 2010 May 17; 23(5):851-60. Patterson AD, Gonzalez FJ, Idle JR. PMID: 20232918; PMCID: PMC2872059.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    465. The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. Mass Spectrom Rev. 2010 May-Jun; 29(3):503-21. Patterson AD, Lanz C, Gonzalez FJ, Idle JR. PMID: 19890938; PMCID: PMC3690279.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansPHPublic Health
    466. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology. 2010 Aug; 139(2):653-63. Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. PMID: 20303349; PMCID: PMC2910786.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    467. Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor alpha and role of the hypothalamic-pituitary-adrenal axis. J Biol Chem. 2010 Mar 05; 285(10):7670-85. Wang T, Shah YM, Matsubara T, Zhen Y, Tanabe T, Nagano T, Fotso S, Krausz KW, Zabriskie TM, Idle JR, Gonzalez FJ. PMID: 20032461; PMCID: PMC2844213.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    468. Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. J Biol Chem. 2010 Jan 29; 285(5):3035-43. Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA. PMID: 19996107; PMCID: PMC2823426.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    469. Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism. Mol Cell Biol. 2010 Feb; 30(3):565-77. Martinez-Jimenez CP, Kyrmizi I, Cardot P, Gonzalez FJ, Talianidis I. PMID: 19933841; PMCID: PMC2812226.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    470. Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge. J Lipid Res. 2010 May; 51(5):1063-74. Cho JY, Matsubara T, Kang DW, Ahn SH, Krausz KW, Idle JR, Luecke H, Gonzalez FJ. PMID: 19965603; PMCID: PMC2853433.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    471. A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19197-202. Guettier JM, Gautam D, Scarselli M, Ruiz de Azua I, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J. PMID: 19858481; PMCID: PMC2767362.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    472. Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol Cell Biol. 2009 Dec; 29(24):6391-400. Sekine H, Mimura J, Oshima M, Okawa H, Kanno J, Igarashi K, Gonzalez FJ, Ikuta T, Kawajiri K, Fujii-Kuriyama Y. PMID: 19822660; PMCID: PMC2786870.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    473. Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium. Mol Cell Biol. 2009 Dec; 29(23):6294-308. Cattin AL, Le Beyec J, Barreau F, Saint-Just S, Houllier A, Gonzalez FJ, Robine S, Pinçon-Raymond M, Cardot P, Lacasa M, Ribeiro A. PMID: 19805521; PMCID: PMC2786690.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    474. Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. Mol Carcinog. 2009 Oct; 48(10):942-52. Foreman JE, Sorg JM, McGinnis KS, Rigas B, Williams JL, Clapper ML, Gonzalez FJ, Peters JM. PMID: 19415698; PMCID: PMC2790141.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    475. The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1587-96. Wang XX, Jiang T, Shen Y, Adorini L, Pruzanski M, Gonzalez FJ, Scherzer P, Lewis L, Miyazaki-Anzai S, Levi M. PMID: 19776172; PMCID: PMC2801344.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    476. The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene. Carcinogenesis. 2009 Nov; 30(11):1957-61. Shi S, Yoon DY, Hodge-Bell KC, Bebenek IG, Whitekus MJ, Zhang R, Cochran AJ, Huerta-Yepez S, Yim SH, Gonzalez FJ, Jaiswal AK, Hankinson O. PMID: 19755658; PMCID: PMC2791324.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    477. Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis. Toxicol Sci. 2010 Jan; 113(1):27-36. Bility MT, Zhu B, Kang BH, Gonzalez FJ, Peters JM. PMID: 19748995; PMCID: PMC2794329.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    478. Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation. J Proteome Res. 2009 Sep; 8(9):4293-300. Patterson AD, Slanar O, Krausz KW, Li F, Höfer CC, Perlík F, Gonzalez FJ, Idle JR. PMID: 19569716; PMCID: PMC2760252.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    479. Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem Pharmacol. 2010 Jan 01; 79(1):57-66. Abdelmegeed MA, Moon KH, Chen C, Gonzalez FJ, Song BJ. PMID: 19660437; PMCID: PMC2784150.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    480. Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res. 2009 Jul; 172(1):42-57. Tyburski JB, Patterson AD, Krausz KW, Slavík J, Fornace AJ, Gonzalez FJ, Idle JR. PMID: 19580506; PMCID: PMC2794378.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    481. Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress. Free Radic Biol Med. 2009 Sep 15; 47(6):767-78. Abdelmegeed MA, Moon KH, Hardwick JP, Gonzalez FJ, Song BJ. PMID: 19539749; PMCID: PMC2759705.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    482. Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor. Toxicol Sci. 2009 Sep; 111(1):19-26. Yanagiba Y, Ito Y, Kamijima M, Gonzalez FJ, Nakajima T. PMID: 19525444.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    483. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos. 2009 Aug; 37(8):1611-21. Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ. PMID: 19460945; PMCID: PMC2712435.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    484. Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. PLoS One. 2009; 4(5):e5489. Li L, Oropeza CE, Sainz B, Uprichard SL, Gonzalez FJ, McLachlan A. PMID: 19424486; PMCID: PMC2674568.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    485. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009 May; 9(5):428-39. Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. PMID: 19416713; PMCID: PMC2803070.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    486. Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha. Toxicol Sci. 2009 Jul; 110(1):204-11. Foreman JE, Chang SC, Ehresman DJ, Butenhoff JL, Anderson CR, Palkar PS, Kang BH, Gonzalez FJ, Peters JM. PMID: 19359353.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    487. Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress. J Hepatol. 2009 Jun; 50(6):1236-46. Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez FJ, Aoyama T. PMID: 19398233; PMCID: PMC2809859.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    488. Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chem Res Toxicol. 2009 Apr; 22(4):699-707. Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ. PMID: 19256530; PMCID: PMC2670930.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    489. Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. Biol Pharm Bull. 2009 Feb; 32(2):172-8. Nomoto M, Miyata M, Yin S, Kurata Y, Shimada M, Yoshinari K, Gonzalez FJ, Suzuki K, Shibasaki S, Kurosawa T, Yamazoe Y. PMID: 19182371; PMCID: PMC2829856.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    490. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab. 2009 Feb; 9(2):152-64. Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ. PMID: 19147412; PMCID: PMC2659630.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    491. Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation. J Lipid Res. 2009 May; 50(5):924-37. Cho JY, Kang DW, Ma X, Ahn SH, Krausz KW, Luecke H, Idle JR, Gonzalez FJ. PMID: 19141872; PMCID: PMC2666179.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    492. Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1. Cell Metab. 2008 Dec; 8(6):482-91. Wang N, Yang G, Jia Z, Zhang H, Aoyagi T, Soodvilai S, Symons JD, Schnermann JB, Gonzalez FJ, Litwin SE, Yang T. PMID: 19041764; PMCID: PMC5484540.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    493. PPAR{alpha} attenuates the proinflammatory response in activated mesangial cells. Am J Physiol Renal Physiol. 2009 Feb; 296(2):F328-36. Kono K, Kamijo Y, Hora K, Takahashi K, Higuchi M, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T. PMID: 19036849.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    494. Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption. Drug Metab Dispos. 2009 Feb; 37(2):338-44. Miyata M, Matsuda Y, Nomoto M, Takamatsu Y, Sato N, Hamatsu M, Dawson PA, Gonzalez FJ, Yamazoe Y. PMID: 18988759; PMCID: PMC2680521.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    495. Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J Pharmacol Exp Ther. 2009 Feb; 328(2):469-77. Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, Pinson D, Gao X, Zhang Y, Ganapathy V, Gonzalez FJ, Guo GL. PMID: 18981289; PMCID: PMC2682273.
      View in: PubMed   Mentions: 126     Fields:    Translation:Animals
    496. Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor. J Toxicol Sci. 2008 Oct; 33(4):405-13. Minami K, Nakajima M, Fujiki Y, Katoh M, Gonzalez FJ, Yokoi T. PMID: 18827440; PMCID: PMC7217312.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    497. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug Metab Dispos. 2008 Dec; 36(12):2506-12. Ma X, Cheung C, Krausz KW, Shah YM, Wang T, Idle JR, Gonzalez FJ. PMID: 18799805; PMCID: PMC2678901.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    498. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. J Pharmacol Exp Ther. 2008 Nov; 327(2):288-99. Cheung C, Gonzalez FJ. PMID: 18682571; PMCID: PMC2597361.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    499. Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci. 2008 Oct; 105(2):418-28. Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM. PMID: 18622026; PMCID: PMC2527639.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    500. The pregnane X receptor: from bench to bedside. Expert Opin Drug Metab Toxicol. 2008 Jul; 4(7):895-908. Ma X, Idle JR, Gonzalez FJ. PMID: 18624678; PMCID: PMC2535920.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    501. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis. 2008 Jul; 14(7):908-20. Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y. PMID: 18338782; PMCID: PMC2435391.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    502. Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiat Res. 2008 Jul; 170(1):1-14. Tyburski JB, Patterson AD, Krausz KW, Slavík J, Fornace AJ, Gonzalez FJ, Idle JR. PMID: 18582157; PMCID: PMC2443732.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    503. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab. 2008 Apr; 7(4):302-11. Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, Gonzalez FJ. PMID: 18396136; PMCID: PMC2587176.
      View in: PubMed   Mentions: 175     Fields:    Translation:AnimalsCells
    504. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology. 2008 Jun; 134(7):2036-48, 2048.e1-3. Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ. PMID: 18439915; PMCID: PMC2533811.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    505. Effects of fibrate drugs on expression of ABCA1 and HDL biogenesis in hepatocytes. J Cardiovasc Pharmacol. 2008 Mar; 51(3):258-66. Hossain MA, Tsujita M, Gonzalez FJ, Yokoyama S. PMID: 18356690.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    506. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab. 2008 Feb; 7(2):135-47. Chen C, Shah YM, Morimura K, Krausz KW, Miyazaki M, Richardson TA, Morgan ET, Ntambi JM, Idle JR, Gonzalez FJ. PMID: 18249173; PMCID: PMC2276699.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    507. Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver. Toxicol Appl Pharmacol. 2008 May 15; 229(1):10-9. Sato S, Shirakawa H, Tomita S, Ohsaki Y, Haketa K, Tooi O, Santo N, Tohkin M, Furukawa Y, Gonzalez FJ, Komai M. PMID: 18295293.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    508. A metabolomic perspective of melatonin metabolism in the mouse. Endocrinology. 2008 Apr; 149(4):1869-79. Ma X, Chen C, Krausz KW, Idle JR, Gonzalez FJ. PMID: 18187545; PMCID: PMC2276702.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    509. UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem. 2008 Feb 01; 80(3):665-74. Patterson AD, Li H, Eichler GS, Krausz KW, Weinstein JN, Fornace AJ, Gonzalez FJ, Idle JR. PMID: 18173289; PMCID: PMC2254319.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    510. Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription. Drug Metab Pharmacokinet. 2008; 23(1):2-7. Gonzalez FJ. PMID: 18305369.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    511. Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice. J Occup Health. 2008; 50(2):169-80. Takashima K, Ito Y, Gonzalez FJ, Nakajima T. PMID: 18403868; PMCID: PMC7217336.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    512. Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. J Biol Chem. 2008 Feb 22; 283(8):4543-59. Chen C, Krausz KW, Idle JR, Gonzalez FJ. PMID: 18093979; PMCID: PMC2268247.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    513. PPARalpha protects proximal tubular cells from acute fatty acid toxicity. J Am Soc Nephrol. 2007 Dec; 18(12):3089-100. Kamijo Y, Hora K, Kono K, Takahashi K, Higuchi M, Ehara T, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T. PMID: 17978304.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    514. Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance. J Pharmacol Exp Ther. 2008 Feb; 324(2):674-84. Wang T, Ma X, Krausz KW, Idle JR, Gonzalez FJ. PMID: 17962516; PMCID: PMC2268525.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    515. PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology. 2008 Apr 03; 246(1):2-8. Gonzalez FJ, Shah YM. PMID: 18006136.
      View in: PubMed   Mentions: 115     Fields:    Translation:Animals
    516. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res. 2007 Dec; 48(12):2664-72. Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, Kliewer SA, Gonzalez FJ. PMID: 17720959.
      View in: PubMed   Mentions: 310     Fields:    Translation:Animals
    517. CCAAT/enhancer-binding protein delta (C/EBPdelta) maintains amelogenin expression in the absence of C/EBPalpha in vivo. J Biol Chem. 2007 Oct 12; 282(41):29882-9. Xu Y, Zhou YL, Gonzalez FJ, Snead ML. PMID: 17704518; PMCID: PMC4445686.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    518. The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. Toxicol Sci. 2008 Jan; 101(1):132-9. Yang Q, Nagano T, Shah Y, Cheung C, Ito S, Gonzalez FJ. PMID: 17690133; PMCID: PMC2197159.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    519. Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. J Clin Invest. 2007 Jul; 117(7):1940-50. Ito S, Chen C, Satoh J, Yim S, Gonzalez FJ. PMID: 17607366; PMCID: PMC1890999.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    520. Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. Mol Endocrinol. 2007 Sep; 21(9):2136-51. Zhen Y, Krausz KW, Chen C, Idle JR, Gonzalez FJ. PMID: 17550978; PMCID: PMC2084472.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    521. Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR. Toxicology. 2007 Sep 05; 238(2-3):147-56. Lee CH, Ito Y, Yanagiba Y, Yamanoshita O, Kim H, Zhang SY, Kamijima M, Gonzalez FJ, Nakajima T. PMID: 17618724.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    522. Animal models for human risk assessment: the peroxisome proliferator-activated receptor alpha-humanized mouse. Nutr Rev. 2007 Jun; 65(6 Pt 2):S2-6. Gonzalez FJ. PMID: 17605307.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    523. Glucocorticoid signaling synchronizes the liver circadian transcriptome. Hepatology. 2007 Jun; 45(6):1478-88. Reddy AB, Maywood ES, Karp NA, King VM, Inoue Y, Gonzalez FJ, Lilley KS, Kyriacou CP, Hastings MH. PMID: 17538967.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    524. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007 Jun; 117(6):1658-69. Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. PMID: 17525798; PMCID: PMC1868788.
      View in: PubMed   Mentions: 259     Fields:    Translation:AnimalsCells
    525. The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. J Lipid Res. 2007 Aug; 48(8):1781-91. Dongol B, Shah Y, Kim I, Gonzalez FJ, Hunt MC. PMID: 17485727.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    526. Rifaximin is a gut-specific human pregnane X receptor activator. J Pharmacol Exp Ther. 2007 Jul; 322(1):391-8. Ma X, Shah YM, Guo GL, Wang T, Krausz KW, Idle JR, Gonzalez FJ. PMID: 17442842.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    527. Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol Cell Biol. 2007 Jun; 27(12):4238-47. Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez FJ. PMID: 17438130; PMCID: PMC1900062.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    528. A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1297-304. Ichihara S, Yamada Y, Ichihara G, Nakajima T, Li P, Kondo T, Gonzalez FJ, Murohara T. PMID: 17413038.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    529. Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site. J Mol Biol. 2007 Jun 08; 369(3):640-52. Arpiainen S, Lämsä V, Pelkonen O, Yim SH, Gonzalez FJ, Hakkola J. PMID: 17466327.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    530. Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice. Drug Metab Dispos. 2007 Jul; 35(7):1223-31. Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF. PMID: 17392391.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    531. Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. Carcinogenesis. 2007 Jun; 28(6):1171-7. Yang Q, Ito S, Gonzalez FJ. PMID: 17331954; PMCID: PMC1885989.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    532. A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach. Chem Res Toxicol. 2007 Mar; 20(3):531-42. Chen C, Ma X, Malfatti MA, Krausz KW, Kimura S, Felton JS, Idle JR, Gonzalez FJ. PMID: 17279779; PMCID: PMC1850849.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    533. CYP3A4 and pregnane X receptor humanized mice. J Biochem Mol Toxicol. 2007; 21(4):158-62. Gonzalez FJ. PMID: 17936928.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    534. LC-MS-based metabolomics in drug metabolism. Drug Metab Rev. 2007; 39(2-3):581-97. Chen C, Gonzalez FJ, Idle JR. PMID: 17786640; PMCID: PMC2140249.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimals
    535. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis. 2007 May; 28(5):940-6. Kim I, Morimura K, Shah Y, Yang Q, Ward JM, Gonzalez FJ. PMID: 17183066; PMCID: PMC1858639.
      View in: PubMed   Mentions: 182     Fields:    Translation:Animals
    536. Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. Am J Physiol Gastrointest Liver Physiol. 2007 Apr; 292(4):G1114-22. Shah YM, Ma X, Morimura K, Kim I, Gonzalez FJ. PMID: 17170021.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    537. Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. Am J Physiol Gastrointest Liver Physiol. 2007 Feb; 292(2):G657-66. Shah YM, Morimura K, Gonzalez FJ. PMID: 17095756; PMCID: PMC1796914.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    538. The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metab Dispos. 2007 Feb; 35(2):194-200. Ma X, Shah Y, Cheung C, Guo GL, Feigenbaum L, Krausz KW, Idle JR, Gonzalez FJ. PMID: 17093002.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    539. The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases. Biochem Pharmacol. 2007 Feb 15; 73(4):561-73. Giri S, Krausz KW, Idle JR, Gonzalez FJ. PMID: 17123469.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    540. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 2007 Mar; 28(3):732-7. Ma X, Idle JR, Malfatti MA, Krausz KW, Nebert DW, Chen CS, Felton JS, Waxman DJ, Gonzalez FJ. PMID: 17052995; PMCID: PMC1829392.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    541. Effects of FXR in foam-cell formation and atherosclerosis development. Biochim Biophys Acta. 2006 Dec; 1761(12):1401-9. Guo GL, Santamarina-Fojo S, Akiyama TE, Amar MJ, Paigen BJ, Brewer B, Gonzalez FJ. PMID: 17110163; PMCID: PMC1751860.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    542. Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane. Drug Metab Dispos. 2007 Jan; 35(1):95-102. Medina-Díaz IM, Arteaga-Illán G, de León MB, Cisneros B, Sierra-Santoyo A, Vega L, Gonzalez FJ, Elizondo G. PMID: 17035600.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    543. The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. Drug Metab Dispos. 2007 Jan; 35(1):1-8. Gonzalez FJ. PMID: 17020953.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    544. Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX. Cancer Res. 2006 Oct 01; 66(19):9656-64. Meng LH, Shankavaram U, Chen C, Agama K, Fu HQ, Gonzalez FJ, Weinstein J, Pommier Y. PMID: 17018623.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    545. Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia. Biochem Biophys Res Commun. 2006 Nov 17; 350(2):370-6. Sugiyama E, Tanaka N, Nakajima T, Kamijo Y, Yokoyama S, Li Y, Gonzalez FJ, Aoyama T. PMID: 17011521.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    546. Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice. Hepatology. 2006 Sep; 44(3):550-60. Yim SH, Shah Y, Tomita S, Morris HD, Gavrilova O, Lambert G, Ward JM, Gonzalez FJ. PMID: 16941684; PMCID: PMC1559728.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    547. Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha. J Lipid Res. 2006 Nov; 47(11):2503-14. Hanniman EA, Lambert G, Inoue Y, Gonzalez FJ, Sinal CJ. PMID: 16929032.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    548. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 2006 Aug 15; 20(16):2293-305. Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez FJ, Talianidis I. PMID: 16912278; PMCID: PMC1553211.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    549. Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR. Mol Cell Endocrinol. 2006 Aug 15; 256(1-2):23-33. Matsusue K, Miyoshi A, Yamano S, Gonzalez FJ. PMID: 16806672; PMCID: PMC1544360.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    550. Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase. Drug Metab Pharmacokinet. 2006 Aug; 21(4):315-23. Miyata M, Matsuda Y, Tsuchiya H, Kitada H, Akase T, Shimada M, Nagata K, Gonzalez FJ, Yamazoe Y. PMID: 16946559.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    551. Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice. Endocrinology. 2006 Oct; 147(10):4772-80. Yang Q, Kurotani R, Yamada A, Kimura S, Gonzalez FJ. PMID: 16857745; PMCID: PMC1570154.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    552. Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. J Biol Chem. 2006 Sep 08; 281(36):26540-51. Ding X, Lichti K, Kim I, Gonzalez FJ, Staudinger JL. PMID: 16825189; PMCID: PMC2991045.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    553. Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha. Mol Pharmacol. 2006 Oct; 70(4):1281-90. Shin M, Kim I, Inoue Y, Kimura S, Gonzalez FJ. PMID: 16807375.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    554. 3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio. Drug Metab Dispos. 2006 Sep; 34(9):1563-74. Zhen Y, Slanar O, Krausz KW, Chen C, Slavík J, McPhail KL, Zabriskie TM, Perlík F, Gonzalez FJ, Idle JR. PMID: 16782768; PMCID: PMC1553181.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    555. Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone). J Pharmacol Exp Ther. 2006 Sep; 318(3):1330-42. Chen C, Meng L, Ma X, Krausz KW, Pommier Y, Idle JR, Gonzalez FJ. PMID: 16775196; PMCID: PMC1551906.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    556. A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. Chem Res Toxicol. 2006 Jun; 19(6):818-27. Giri S, Idle JR, Chen C, Zabriskie TM, Krausz KW, Gonzalez FJ. PMID: 16780361; PMCID: PMC1482804.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    557. Urinary metabolites and antioxidant products of exogenous melatonin in the mouse. J Pineal Res. 2006 May; 40(4):343-9. Ma X, Idle JR, Krausz KW, Tan DX, Ceraulo L, Gonzalez FJ. PMID: 16635022; PMCID: PMC1448215.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    558. Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J Biol Chem. 2006 Jun 16; 281(24):16625-31. Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M. PMID: 16606610.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    559. Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stress. Biochem J. 2006 Mar 01; 394(Pt 2):e3-5. Gonzalez FJ. PMID: 16479620; PMCID: PMC1408685.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    560. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PMID: 16492734; PMCID: PMC1413918.
      View in: PubMed   Mentions: 214     Fields:    Translation:AnimalsCells
    561. Alterations in skin and stratified epithelia by constitutively activated PPARalpha. J Invest Dermatol. 2006 Feb; 126(2):374-85. Yang Q, Yamada A, Kimura S, Peters JM, Gonzalez FJ. PMID: 16374467.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    562. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem. 2006 Apr 21; 281(16):11039-49. Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, Abdelkarim M, Caron S, Torpier G, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B. PMID: 16446356.
      View in: PubMed   Mentions: 235     Fields:    Translation:AnimalsCells
    563. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):1006-11. Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, Edwards PA. PMID: 16410358; PMCID: PMC1347977.
      View in: PubMed   Mentions: 410     Fields:    Translation:AnimalsCells
    564. Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol. 2006; 46:41-64. Gonzalez FJ, Yu AM. PMID: 16402898; PMCID: PMC1440291.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    565. Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression. J Mol Med (Berl). 2006 Apr; 84(4):334-44. Inoue Y, Peters LL, Yim SH, Inoue J, Gonzalez FJ. PMID: 16389552.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    566. Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis. Carcinogenesis. 2006 May; 27(5):1074-80. Morimura K, Cheung C, Ward JM, Reddy JK, Gonzalez FJ. PMID: 16377806; PMCID: PMC1447533.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    567. The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab. 2005 Dec; 2(6):373-84. Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K. PMID: 16330323.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    568. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther. 2006 Mar; 316(3):1328-34. Cheung C, Yu AM, Chen CS, Krausz KW, Byrd LG, Feigenbaum L, Edwards RJ, Waxman DJ, Gonzalez FJ. PMID: 16291874.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    569. Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha. Biochem Biophys Res Commun. 2006 Jan 06; 339(1):196-203. Lee H, Gonzalez FJ, Yoon M. PMID: 16297877.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    570. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. J Lipid Res. 2006 Jan; 47(1):215-27. Inoue Y, Yu AM, Yim SH, Ma X, Krausz KW, Inoue J, Xiang CC, Brownstein MJ, Eggertsen G, Björkhem I, Gonzalez FJ. PMID: 16264197; PMCID: PMC1413576.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    571. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res. 2006 Jan; 47(1):201-14. Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA. PMID: 16251721.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    572. Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G1016-24. Bosse T, van Wering HM, Gielen M, Dowling LN, Fialkovich JJ, Piaseckyj CM, Gonzalez FJ, Akiyama TE, Montgomery RK, Grand RJ, Krasinski SD. PMID: 16223943.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    573. Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2. Chem Res Toxicol. 2005 Sep; 18(9):1471-8. Cheung C, Ma X, Krausz KW, Kimura S, Feigenbaum L, Dalton TP, Nebert DW, Idle JR, Gonzalez FJ. PMID: 16167840.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    574. Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12531-6. Jia Y, Guo GL, Surapureddi S, Sarkar J, Qi C, Guo D, Xia J, Kashireddi P, Yu S, Cho YW, Rao MS, Kemper B, Ge K, Gonzalez FJ, Reddy JK. PMID: 16109766; PMCID: PMC1187948.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    575. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005 Aug 12; 122(3):337-49. Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. PMID: 16096055.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    576. Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett. 2005 Aug 01; 579(19):4076-80. Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk T, Grefhorst A, Bouchaert E, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B. PMID: 16023103.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    577. Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9406-11. Zhang H, Zhang A, Kohan DE, Nelson RD, Gonzalez FJ, Yang T. PMID: 15956187; PMCID: PMC1166599.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    578. The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. J Biol Chem. 2005 Aug 19; 280(33):29971-9. Duran-Sandoval D, Cariou B, Percevault F, Hennuyer N, Grefhorst A, van Dijk TH, Gonzalez FJ, Fruchart JC, Kuipers F, Staels B. PMID: 15899888.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    579. Potential role for human cytochrome P450 3A4 in estradiol homeostasis. Endocrinology. 2005 Jul; 146(7):2911-9. Yu AM, Fukamachi K, Krausz KW, Cheung C, Gonzalez FJ. PMID: 15817670.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    580. PPARgamma in endothelial cells influences high fat diet-induced hypertension. Am J Hypertens. 2005 Apr; 18(4 Pt 1):549-56. Nicol CJ, Adachi M, Akiyama TE, Gonzalez FJ. PMID: 15831367.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    581. Getting fat: two new players in molecular adipogenesis. Cell Metab. 2005 Feb; 1(2):85-6. Gonzalez FJ. PMID: 16054047.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    582. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat Res. 2005 Jan 06; 569(1-2):101-10. Gonzalez FJ. PMID: 15603755.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimals
    583. Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):585-91. Duez H, Lefebvre B, Poulain P, Torra IP, Percevault F, Luc G, Peters JM, Gonzalez FJ, Gineste R, Helleboid S, Dzavik V, Fruchart JC, Fiévet C, Lefebvre P, Staels B. PMID: 15618549.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCTClinical Trials
    584. Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr; 33(4):489-94. Ma X, Idle JR, Krausz KW, Gonzalez FJ. PMID: 15616152.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    585. Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett. 2004 Dec 03; 578(1-2):63-8. Kamiya A, Inoue Y, Kodama T, Gonzalez FJ. PMID: 15581617.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    586. The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metab Dispos. 2005 Mar; 33(3):449-57. Cheung C, Yu AM, Ward JM, Krausz KW, Akiyama TE, Feigenbaum L, Gonzalez FJ. PMID: 15576447.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    587. Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice. Biochem Pharmacol. 2004 Dec 01; 68(11):2143-50. Yang Q, Gonzalez FJ. PMID: 15498504.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    588. Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice. Toxicol Pathol. 2004 Nov-Dec; 32(6):710-8. Ward JM, Nikolov NP, Tschetter JR, Kopp JB, Gonzalez FJ, Kimura S, Siegel RM. PMID: 15580705.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    589. Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity. J Pharmacol Exp Ther. 2005 Feb; 312(2):759-66. Miyata M, Tozawa A, Otsuka H, Nakamura T, Nagata K, Gonzalez FJ, Yamazoe Y. PMID: 15466244.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    590. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology. 2004 Oct; 40(4):972-80. Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T. PMID: 15382117.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    591. Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol Sci. 2004 Dec; 82(2):374-80. Guo GL, Moffit JS, Nicol CJ, Ward JM, Aleksunes LA, Slitt AL, Kliewer SA, Manautou JE, Gonzalez FJ. PMID: 15456926.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    592. Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis. 2005 Jan; 26(1):219-27. Hays T, Rusyn I, Burns AM, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM. PMID: 15447978.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    593. TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices. Hepatology. 2004 Sep; 40(3):527-36. Kamiya A, Gonzalez FJ. PMID: 15349890.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    594. Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice. Mol Endocrinol. 2004 Nov; 18(11):2751-64. Matsusue K, Gavrilova O, Lambert G, Brewer HB, Ward JM, Inoue Y, LeRoith D, Gonzalez FJ. PMID: 15319454.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    595. Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis. J Biol Chem. 2004 Oct 22; 279(43):44740-8. Inoue Y, Inoue J, Lambert G, Yim SH, Gonzalez FJ. PMID: 15292250.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    596. Regulation of drug transporters by the farnesoid X receptor in mice. Mol Pharm. 2004 Jul-Aug; 1(4):281-9. Maeda T, Miyata M, Yotsumoto T, Kobayashi D, Nozawa T, Toyama K, Gonzalez FJ, Yamazoe Y, Tamai I. PMID: 15981587.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    597. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. J Biol Chem. 2004 Aug 13; 279(33):35017-24. Miyazaki M, Dobrzyn A, Sampath H, Lee SH, Man WC, Chu K, Peters JM, Gonzalez FJ, Ntambi JM. PMID: 15180999.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    598. The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Endocrinology. 2004 Sep; 145(9):4268-77. Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F. PMID: 15178647.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    599. Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha. Cancer Res. 2004 Jun 01; 64(11):3849-54. Cheung C, Akiyama TE, Ward JM, Nicol CJ, Feigenbaum L, Vinson C, Gonzalez FJ. PMID: 15172993.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    600. Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab Rev. 2004 May; 36(2):243-77. Yu AM, Idle JR, Gonzalez FJ. PMID: 15237854.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    601. Cytochrome P450 humanised mice. Hum Genomics. 2004 May; 1(4):300-6. Gonzalez FJ. PMID: 15588489; PMCID: PMC3525262.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    602. PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis. Carcinogenesis. 2004 Sep; 25(9):1747-55. Nicol CJ, Yoon M, Ward JM, Yamashita M, Fukamachi K, Peters JM, Gonzalez FJ. PMID: 15073042.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    603. Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem. 2004 Jun 04; 279(23):24427-34. Jia Y, Qi C, Kashireddi P, Surapureddi S, Zhu YJ, Rao MS, Le Roith D, Chambon P, Gonzalez FJ, Reddy JK. PMID: 15150259.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    604. Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. Nat Med. 2004 May; 10(5):481-3. Harman FS, Nicol CJ, Marin HE, Ward JM, Gonzalez FJ, Peters JM. PMID: 15048110.
      View in: PubMed   Mentions: 97     Fields:    Translation:Animals
    605. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem. 2004 Jun 04; 279(23):23847-50. Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. PMID: 15028720.
      View in: PubMed   Mentions: 345     Fields:    Translation:HumansAnimalsCells
    606. Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet. J Biol Chem. 2004 May 14; 279(20):20874-81. Akiyama TE, Lambert G, Nicol CJ, Matsusue K, Peters JM, Brewer HB, Gonzalez FJ. PMID: 15001574.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    607. Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice. FEBS Lett. 2004 Jan 30; 558(1-3):96-100. Nukaya M, Takahashi Y, Gonzalez FJ, Kamataki T. PMID: 14759523.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    608. Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Mol Endocrinol. 2004 Apr; 18(4):851-62. Zhang Y, Repa JJ, Inoue Y, Hayhurst GP, Gonzalez FJ, Mangelsdorf DJ. PMID: 14715930.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    609. Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion. Hepatology. 2004 Jan; 39(1):157-66. Andreola F, Calvisi DF, Elizondo G, Jakowlew SB, Mariano J, Gonzalez FJ, De Luca LM. PMID: 14752834.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    610. Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice. J Biol Chem. 2004 Jan 30; 279(5):3434-8. Andreola F, Hayhurst GP, Luo G, Ferguson SS, Gonzalez FJ, Goldstein JA, De Luca LM. PMID: 14623888.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    611. Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice. Biochem Pharmacol. 2003 Nov 15; 66(10):2011-20. Cheung C, Akiyama TE, Kudo G, Gonzalez FJ. PMID: 14599559.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    612. Role of gene knockout and transgenic mice in the study of xenobiotic metabolism. Drug Metab Rev. 2003 Nov; 35(4):319-35. Gonzalez FJ. PMID: 14705864.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    613. Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation. J Lipid Res. 2004 Feb; 45(2):244-52. Jiang YJ, Lu B, Xu FY, Gartshore J, Taylor WA, Halayko AJ, Gonzalez FJ, Takasaki J, Choy PC, Hatch GM. PMID: 14594999.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    614. Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation. J Biol Chem. 2004 Jan 23; 279(4):2480-9. Inoue Y, Yu AM, Inoue J, Gonzalez FJ. PMID: 14583614.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    615. T cell-specific disruption of arylhydrocarbon receptor nuclear translocator (Arnt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution. J Immunol. 2003 Oct 15; 171(8):4113-20. Tomita S, Jiang HB, Ueno T, Takagi S, Tohi K, Maekawa S, Miyatake A, Furukawa A, Gonzalez FJ, Takeda J, Ichikawa Y, Takahama Y. PMID: 14530333.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    616. Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J Hepatol. 2003 Oct; 39(4):480-8. Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, Gonzalez FJ, Marschall HU, Zatloukal K, Denk H, Trauner M. PMID: 12971955.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    617. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol. 2003 Oct; 23(20):7222-9. Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. PMID: 14517292; PMCID: PMC230305.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    618. Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol. 2003 Oct; 23(19):6739-49. Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, Gonzalez FJ, Takahama Y. PMID: 12972594; PMCID: PMC193947.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    619. Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology. 2003 Sep; 125(3):825-38. Wagner M, Fickert P, Zollner G, Fuchsbichler A, Silbert D, Tsybrovskyy O, Zatloukal K, Guo GL, Schuetz JD, Gonzalez FJ, Marschall HU, Denk H, Trauner M. PMID: 12949728.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    620. Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem. 2003 Nov 14; 278(46):45062-71. Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB, Kliewer SA, Gonzalez FJ, Sinal CJ. PMID: 12923173.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    621. Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology. 2003 Aug; 125(2):544-55. Claudel T, Inoue Y, Barbier O, Duran-Sandoval D, Kosykh V, Fruchart J, Fruchart JC, Gonzalez FJ, Staels B. PMID: 12891557.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    622. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest. 2003 Aug; 112(4):608-18. Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR. PMID: 12925701; PMCID: PMC171387.
      View in: PubMed   Mentions: 172     Fields:    Translation:Animals
    623. Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones. Drug Metab Dispos. 2003 Jul; 31(7):924-31. Hu M, Krausz K, Chen J, Ge X, Li J, Gelboin HL, Gonzalez FJ. PMID: 12814970.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    624. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem. 2003 Sep 05; 278(36):34268-76. Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML. PMID: 12805374.
      View in: PubMed   Mentions: 346     Fields:    Translation:Animals
    625. Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice. Biochim Biophys Acta. 2003 Jun 10; 1632(1-3):80-9. Peters JM, Aoyama T, Burns AM, Gonzalez FJ. PMID: 12782154.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    626. Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics. 2003 Jun; 13(6):307-19. Yu AM, Idle JR, Herraiz T, Küpfer A, Gonzalez FJ. PMID: 12777961.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    627. Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology. 2003 Jun; 37(6):1375-84. Kamiya A, Inoue Y, Gonzalez FJ. PMID: 12774017.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    628. In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha. FEBS Lett. 2003 May 22; 543(1-3):120-4. Tanaka N, Hora K, Makishima H, Kamijo Y, Kiyosawa K, Gonzalez FJ, Aoyama T. PMID: 12753917.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    629. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6712-7. Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK. PMID: 12740443; PMCID: PMC164512.
      View in: PubMed   Mentions: 169     Fields:    Translation:Cells
    630. Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. Drug Metab Dispos. 2003 May; 31(5):548-58. Granvil CP, Yu AM, Elizondo G, Akiyama TE, Cheung C, Feigenbaum L, Krausz KW, Gonzalez FJ. PMID: 12695342.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    631. Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles. Toxicol Pathol. 2003 May-Jun; 31(3):295-303. Yim SH, Ward JM, Dragan Y, Yamada A, Scacheri PC, Kimura S, Gonzalez FJ. PMID: 12746117.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    632. Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine. J Pharmacol Exp Ther. 2003 Apr; 305(1):315-22. Yu AM, Idle JR, Krausz KW, Küpfer A, Gonzalez FJ. PMID: 12649384.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    633. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4012-7. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM. PMID: 12651943; PMCID: PMC153039.
      View in: PubMed   Mentions: 254     Fields:    Translation:AnimalsCells
    634. Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. J Biol Chem. 2003 May 16; 278(20):17838-44. Kitada H, Miyata M, Nakamura T, Tozawa A, Honma W, Shimada M, Nagata K, Sinal CJ, Guo GL, Gonzalez FJ, Yamazoe Y. PMID: 12637555.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    635. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest. 2003 Mar; 111(5):737-47. Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B, Reitman ML, Gonzalez FJ. PMID: 12618528; PMCID: PMC151902.
      View in: PubMed   Mentions: 269     Fields:    Translation:Animals
    636. Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2. Carcinogenesis. 2003 Mar; 24(3):583-7. Kimura S, Kawabe M, Yu A, Morishima H, Fernandez-Salguero P, Hammons GJ, Ward JM, Kadlubar FF, Gonzalez FJ. PMID: 12663521.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    637. Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. Pharmacogenetics. 2003 Mar; 13(3):173-81. Yu AM, Idle JR, Byrd LG, Krausz KW, Küpfer A, Gonzalez FJ. PMID: 12618595.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    638. Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochim Biophys Acta. 2003 Feb 17; 1619(3):223-34. Akiyama TE, Gonzalez FJ. PMID: 12573481.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    639. The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine. J Pharmacol Exp Ther. 2003 Feb; 304(2):539-46. Yu AM, Granvil CP, Haining RL, Krausz KW, Corchero J, Küpfer A, Idle JR, Gonzalez FJ. PMID: 12538805.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    640. Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle. Lab Invest. 2003 Feb; 83(2):259-69. Nöhammer C, Brunner F, Wölkart G, Staber PB, Steyrer E, Gonzalez FJ, Zechner R, Hoefler G. PMID: 12594240.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    641. Study of P450 function using gene knockout and transgenic mice. Arch Biochem Biophys. 2003 Jan 01; 409(1):153-8. Gonzalez FJ, Kimura S. PMID: 12464254.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    642. Transgenic models in xenobiotic metabolism and toxicology. Toxicology. 2002 Dec 27; 181-182:237-9. Gonzalez FJ. PMID: 12505317.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    643. Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C1090-9. Guo H, Wei J, Inoue Y, Gonzalez FJ, Kuo PC. PMID: 12466152.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    644. Positive regulation of connexin32 transcription by hepatocyte nuclear factor-1alpha. Arch Biochem Biophys. 2002 Nov 15; 407(2):160-7. Koffler LD, Fernstrom MJ, Akiyama TE, Gonzalez FJ, Ruch RJ. PMID: 12413486.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    645. The farnesoid X-receptor is an essential regulator of cholesterol homeostasis. J Biol Chem. 2003 Jan 24; 278(4):2563-70. Lambert G, Amar MJ, Guo G, Brewer HB, Gonzalez FJ, Sinal CJ. PMID: 12421815.
      View in: PubMed   Mentions: 151     Fields:    Translation:Animals
    646. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J Biol Chem. 2003 Jan 03; 278(1):498-505. Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, Rao MS, Gonzalez FJ, Reddy JK. PMID: 12401792.
      View in: PubMed   Mentions: 260     Fields:    Translation:AnimalsCells
    647. APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13771-6. Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, Nambiar P, Rosenberg DW, Bronson RT, Edelmann W, Kucherlapati R, Gonzalez FJ, Spiegelman BM. PMID: 12370429; PMCID: PMC129773.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimals
    648. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem. 2002 Oct 25; 277(43):41163-70. Courselaud B, Pigeon C, Inoue Y, Inoue J, Gonzalez FJ, Leroyer P, Gilot D, Boudjema K, Guguen-Guillouzo C, Brissot P, Loréal O, Ilyin G. PMID: 12183449.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    649. The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis. Mol Cell Endocrinol. 2002 Jul 31; 193(1-2):71-9. Gonzalez FJ. PMID: 12161004.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    650. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). J Biol Chem. 2002 Oct 11; 277(41):37991-8000. Louet JF, Hayhurst G, Gonzalez FJ, Girard J, Decaux JF. PMID: 12107181.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    651. Identification of functions of peroxisome proliferator-activated receptor alpha in proximal tubules. J Am Soc Nephrol. 2002 Jul; 13(7):1691-702. Kamijo Y, Hora K, Tanaka N, Usuda N, Kiyosawa K, Nakajima T, Gonzalez FJ, Aoyama T. PMID: 12089364.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    652. 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. J Pharmacol Exp Ther. 2002 Jun; 301(3):1025-32. Granvil CP, Krausz KW, Gelboin HV, Idle JR, Gonzalez FJ. PMID: 12023534.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    653. Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo. J Biol Chem. 2002 Jul 12; 277(28):25257-65. Inoue Y, Hayhurst GP, Inoue J, Mori M, Gonzalez FJ. PMID: 11994307.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    654. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002 May 31; 296(5573):1703-6. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. PMID: 11988537.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    655. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002 Apr; 22(8):2607-19. Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee YH, Ricote M, Glass CK, Brewer HB, Gonzalez FJ. PMID: 11909955; PMCID: PMC133709.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    656. Selective intranuclear redistribution of PPAR isoforms by RXR alpha. Mol Endocrinol. 2002 Apr; 16(4):707-21. Akiyama TE, Baumann CT, Sakai S, Hager GL, Gonzalez FJ. PMID: 11923467.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    657. Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem. 2002 May 17; 277(20):17830-5. Cui Y, Miyoshi K, Claudio E, Siebenlist UK, Gonzalez FJ, Flaws J, Wagner KU, Hennighausen L. PMID: 11884400.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    658. The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility. Genesis. 2002 Mar; 32(3):231-9. Le Provost F, Riedlinger G, Hee Yim S, Benedict J, Gonzalez FJ, Flaws J, Hennighausen L. PMID: 11892012.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    659. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 2002 Jan 01; 16(1):22-6. Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM. PMID: 11782441; PMCID: PMC155311.
      View in: PubMed   Mentions: 611     Fields:    Translation:AnimalsCells
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