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    Louis Dubeau, MD, PhD

    TitleProfessor of Pathology
    SchoolKeck School of Medicine of USC
    DepartmentPathology
    AddressNOR 6338. 1441 Eastlake Avenue
    Health Sciences Campus
    Los Angeles California 90089-9176
    Phone+1 323 865 0720
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      For many years, Dr. Dubeau has been a leading practitioner, educator and researcher in the field of ovarian cancer biology. A native of Canada, Dr. Dubeau first came to USC as a post-doctoral fellow at the Norris Comprehensive Cancer Center. During his time at USC, Dr. Dubeau has achieved the status of full professor, become director of the Molecular Diagnostics Laboratory at USC/Norris Comprehensive Cancer Center published numerous peer-reviewed articles for medical journals and lectured at medical conferences and seminars across the United States, Canada, United Kingdom, Hungary, Turkey and Greece. Dr. Dubeau is a renowned researcher and has been awarded over fourteen million dollars in research grants, many dealing with either ovarian cancer biology and genetics or with environmental issues such as exposure to and effects of air pollution. A devoted educator, Dr. Dubeau has mentored over fifty students, either as a member of their PhD advisory committee or by training doctoral and graduate students. Dr. Dubeau also has found time throughout his career to give lectures on health related subjects to area public school students.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Shen J, Ha DP, Zhu G, Rangel DF, Kobielak A, Gill PS, Groshen S, Dubeau L, Lee AS. GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice. Proc Natl Acad Sci U S A. 2017 May 16; 114(20):E4020-E4029. PMID: 28461470.
        View in: PubMed
      2. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 Feb 01; 7:40919. PMID: 28145503.
        View in: PubMed
      3. Kiechl S, Schramek D, Widschwendter M, Fourkala EO, Zaikin A, Jones A, Jaeger B, Rack B, Janni W, Scholz C, Willeit J, Weger S, Mayr A, Teschendorff A, Rosenthal A, Fraser L, Philpott S, Dubeau L, Keshtgar M, Roylance R, Jacobs IJ, Menon U, Schett G, Penninger JM. Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer. Oncotarget. 2017 Jan 17; 8(3):3811-3825. PMID: 28002811.
        View in: PubMed
      4. Bartlett TE, Chindera K, McDermott J, Breeze CE, Cooke WR, Jones A, Reisel D, Karegodar ST, Arora R, Beck S, Menon U, Dubeau L, Widschwendter M. Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution. Nat Commun. 2016 May 24; 7:11620. PMID: 27216078; PMCID: PMC4890182.
      5. Shen J, Yao L, Lin YG, DeMayo FJ, Lydon JP, Dubeau L, Lee AS. Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget. 2016 Mar 22; 7(12):14885-97. PMID: 26910913; PMCID: PMC4924759.
      6. Teschendorff AE, Lee SH, Jones A, Fiegl H, Kalwa M, Wagner W, Chindera K, Evans I, Dubeau L, Orjalo A, Horlings HM, Niederreiter L, Kaser A, Yang W, Goode EL, Fridley BL, Jenner RG, Berns EM, Wik E, Salvesen HB, Wisman GB, van der Zee AG, Davidson B, Trope CG, Lambrechts S, Vergote I, Calvert H, Jacobs IJ, Widschwendter M. HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. Genome Med. 2015 Oct 24; 7:108. PMID: 26497652; PMCID: PMC4619324.
      7. Liu Y, Pike MC, Wu N, Lin YG, Mucowski S, Punj V, Tang Y, Yen HY, Stanczyk FZ, Enbom E, Austria T, Widschwendter M, Maxson R, Dubeau L. Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent. PLoS One. 2015; 10(10):e0139013. PMID: 26488398; PMCID: PMC4619541.
      8. Widschwendter M, Burnell M, Fraser L, Rosenthal AN, Philpott S, Reisel D, Dubeau L, Cline M, Pan Y, Yi PC, Gareth Evans D, Jacobs IJ, Menon U, Wood CE, Dougall WC. Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-?B Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers. EBioMedicine. 2015 Oct; 2(10):1331-9. PMID: 26629528; PMCID: PMC4634624.
      9. Liu Y, Yen HY, Austria T, Pettersson J, Peti-Peterdi J, Maxson R, Widschwendter M, Dubeau L. A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State. EBioMedicine. 2015 Oct; 2(10):1318-30. PMID: 26629527; PMCID: PMC4634618.
      10. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. PMID: 26094889; PMCID: PMC4509734.
      11. Dubeau L. Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications. Transl Cancer Res. 2015 Feb; 4(1):3-13. PMID: 26568913.
        View in: PubMed
      12. Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles BL, Johnson DL. Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789. PMID: 25502566; PMCID: PMC4263377.
      13. Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, Schönthal AH, Hofman FM, Chen TC. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol Cancer Ther. 2014 Aug; 13(8):2004-17. PMID: 24994771.
        View in: PubMed
      14. Widschwendter M, Rosenthal AN, Philpott S, Rizzuto I, Fraser L, Hayward J, Intermaggio MP, Edlund CK, Ramus SJ, Gayther SA, Dubeau L, Fourkala EO, Zaikin A, Menon U, Jacobs IJ. The sex hormone system in carriers of BRCA1/2 mutations: a case-control study. Lancet Oncol. 2013 Nov; 14(12):1226-32. PMID: 24140203.
        View in: PubMed
      15. Matsuo K, Gray MJ, Yang DY, Srivastava SA, Tripathi PB, Sonoda LA, Yoo EJ, Dubeau L, Lee AS, Lin YG. The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol Oncol. 2013 Mar; 128(3):552-9. PMID: 23200913; PMCID: PMC4199224.
      16. Yen HY, Gabet Y, Liu Y, Martin A, Wu NL, Pike MC, Frenkel B, Maxson R, Dubeau L. Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs. Lab Invest. 2012 Jun; 92(6):802-11. PMID: 22488153; PMCID: PMC4530993.
      17. Campan M, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, Dubeau L, Siegmund KD, Wu AH, Groshen S, Chandavarkar U, Roman LD, Berchuck A, Pearce CL, Laird PW. Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. PLoS One. 2011; 6(12):e28141. PMID: 22163280; PMCID: PMC3233546.
      18. Yu VM, Marion CM, Austria TM, Yeh J, Schönthal AH, Dubeau L. Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells. Int J Cancer. 2012 Jun 01; 130(11):2495-504. PMID: 21792894; PMCID: PMC3299830.
      19. Lagos-Jaramillo VI, Press MF, Ricker CN, Dubeau L, Mai PL, Weitzel JN. Pathological characteristics of BRCA-associated breast cancers in Hispanics. Breast Cancer Res Treat. 2011 Nov; 130(1):281-9. PMID: 21604016; PMCID: PMC3526343.
      20. Hong H, Yen HY, Brockmeyer A, Liu Y, Chodankar R, Pike MC, Stanczyk FZ, Maxson R, Dubeau L. Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer. Cancer Res. 2010 Jan 01; 70(1):221-8. PMID: 20028858; PMCID: PMC2805040.
      21. Widschwendter M, Apostolidou S, Jones AA, Fourkala EO, Arora R, Pearce CL, Frasco MA, Ayhan A, Zikan M, Cibula D, Iyibozkurt CA, Yavuz E, Hauser-Kronberger C, Dubeau L, Menon U, Jacobs IJ. HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study. Int J Cancer. 2009 Nov 01; 125(9):2214-8. PMID: 19621443.
        View in: PubMed
      22. Shao C, Lacey M, Dubeau L, Ehrlich M. Hemimethylation footprints of DNA demethylation in cancer. Epigenetics. 2009 Apr 01; 4(3):165-75. PMID: 19287214.
        View in: PubMed
      23. Dubeau L. The cell of origin of ovarian epithelial tumours. Lancet Oncol. 2008 Dec; 9(12):1191-7. PMID: 19038766; PMCID: PMC4176875.
      24. Johnson SA, Dubeau L, Johnson DL. Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. J Biol Chem. 2008 Jul 11; 283(28):19184-91. PMID: 18456653; PMCID: PMC2443659.
      25. Yoo CB, Chuang JC, Byun HM, Egger G, Yang AS, Dubeau L, Long T, Laird PW, Marquez VE, Jones PA. Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila). 2008 Sep; 1(4):233-40. PMID: 19138966.
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      26. Dong D, Ni M, Li J, Xiong S, Ye W, Virrey JJ, Mao C, Ye R, Wang M, Pen L, Dubeau L, Groshen S, Hofman FM, Lee AS. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res. 2008 Jan 15; 68(2):498-505. PMID: 18199545.
        View in: PubMed
      27. Dubeau L. BRCA1-induced ovarian oncogenesis. Adv Exp Med Biol. 2008; 622:89-97. PMID: 18546621.
        View in: PubMed
      28. Shelbourne PF, Keller-McGandy C, Bi WL, Yoon SR, Dubeau L, Veitch NJ, Vonsattel JP, Wexler NS, Arnheim N, Augood SJ. Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain. Hum Mol Genet. 2007 May 15; 16(10):1133-42. PMID: 17409200.
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      29. Li YF, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6. PMID: 16456144; PMCID: PMC2662916.
      30. Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1563-8. PMID: 16166621; PMCID: PMC2718456.
      31. Li YF, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. Intercellular adhesion molecule-1 and childhood asthma. Hum Genet. 2005 Sep; 117(5):476-84. PMID: 16021473.
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      32. Grunau C, Sanchez C, Ehrlich M, van der Bruggen P, Hindermann W, Rodriguez C, Krieger S, Dubeau L, Fiala E, De Sario A. Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. Genes Chromosomes Cancer. 2005 May; 43(1):11-24. PMID: 15704127.
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      33. Nishiyama R, Qi L, Tsumagari K, Weissbecker K, Dubeau L, Champagne M, Sikka S, Nagai H, Ehrlich M. A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others. Cancer Biol Ther. 2005 Apr; 4(4):440-8. PMID: 15846090.
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      34. Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen HY, Deng C, Pike MC, Shuler CF, Maxson R, Dubeau L. Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. Curr Biol. 2005 Mar 29; 15(6):561-5. PMID: 15797026.
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      35. Dong D, Dubeau L, Bading J, Nguyen K, Luna M, Yu H, Gazit-Bornstein G, Gordon EM, Gomer C, Hall FL, Gambhir SS, Lee AS. Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors. Hum Gene Ther. 2004 Jun; 15(6):553-61. PMID: 15212714.
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      36. Nouriani M, Bahador A, Berek JS, Cheng JP, Chi DS, Cliby WA, Del Priore G, Dodson MK, Duggan BD, Gershenson DM, Lentz SE, Penson RT, Robinson WR, Rodriguez M, Roman LD, Yu MC, Zempolich K, Dubeau L. Detection of residual subclinical ovarian carcinoma after completion of adjuvant chemotherapy. Clin Cancer Res. 2004 Apr 15; 10(8):2681-6. PMID: 15102671.
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      37. Blumenthal M, Kardosh A, Dubeau L, Borok Z, Schönthal AH. Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone. Mol Carcinog. 2003 Dec; 38(4):160-9. PMID: 14639655.
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      38. Velicescu M, Yu J, Herbert BS, Shay JW, Granada E, Dubeau L. Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells. Cancer Res. 2003 Sep 15; 63(18):5813-20. PMID: 14522904.
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      39. Johnson SA, Dubeau L, White RJ, Johnson DL. The TATA-binding protein as a regulator of cellular transformation. Cell Cycle. 2003 Sep-Oct; 2(5):442-4. PMID: 12963838.
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      40. Yoon SR, Dubeau L, de Young M, Wexler NS, Arnheim N. Huntington disease expansion mutations in humans can occur before meiosis is completed. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8834-8. PMID: 12857955; PMCID: PMC166399.
      41. Johnson SA, Dubeau L, Kawalek M, Dervan A, Schönthal AH, Dang CV, Johnson DL. Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis. Mol Cell Biol. 2003 May; 23(9):3043-51. PMID: 12697807; PMCID: PMC153209.
      42. Reddy RK, Dubeau L, Kleiner H, Parr T, Nichols P, Ko B, Dong D, Ko H, Mao C, DiGiovanni J, Lee AS. Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages. Cancer Res. 2002 Dec 15; 62(24):7207-12. PMID: 12499260.
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      43. Velicescu M, Dubeau L. p53: a key player in the telomere dynamics. Cancer Biol Ther. 2002 Sep-Oct; 1(5):518-9. PMID: 12496480.
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      44. Gilliland FD, Gauderman WJ, Vora H, Rappaport E, Dubeau L. Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth. Am J Respir Crit Care Med. 2002 Sep 01; 166(5):710-6. PMID: 12204870.
        View in: PubMed
      45. Gilliland FD, Li YF, Dubeau L, Berhane K, Avol E, McConnell R, Gauderman WJ, Peters JM. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63. PMID: 12186820.
        View in: PubMed
      46. Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51. PMID: 12153968.
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      47. Chen C, Petitclerc E, Zhou H, Brooks PC, Sun T, Yu MC, Zheng W, Dubeau L. Effect of reproductive hormones on ovarian epithelial tumors: II. Effect on angiogenic activity. Cancer Biol Ther. 2002 May-Jun; 1(3):307-12. PMID: 12432284.
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      48. Zhou H, Luo MP, Schönthal AH, Pike MC, Stallcup MR, Blumenthal M, Zheng W, Dubeau L. Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activity. Cancer Biol Ther. 2002 May-Jun; 1(3):300-6. PMID: 12432283.
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      49. Yu J, Dubeau L. Telomerase and malignant transformation. Cancer Treat Res. 2002; 107:213-28. PMID: 11775451.
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