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Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis. Cancers (Basel). 2024 Mar 18; 16(6).
Haran S, Chindera K, Sabry M, Wilkinson N, Arora R, Zubiak A, Bartlett TE, Evans I, Jones A, Reisel D, Herzog C, Alkasalias T, Newman M, Kim J, Rådestad AF, Gemzell-Danielsson K, Rosenthal AN, Dubeau L, Lowdell MW, Widschwendter M. PMID: 38539519; PMCID: PMC10968968.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract. Cold Spring Harb Perspect Med. 2023 07 05; 13(7).
Austria T, Dubeau L. PMID: 37163330; PMCID: PMC10317069.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage. Viruses. 2023 05 06; 15(5).
Ha DP, Shin WJ, Hernandez JC, Neamati N, Dubeau L, Machida K, Lee AS. PMID: 37243204; PMCID: PMC10220750.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Correction: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women. Genome Med. 2022 Jul 19; 14(1):76.
Bartlett TE, Evans I, Jones A, Barrett JE, Haran S, Reisel D, Papaikonomou K, Jones L, Herzog C, Pashayan N, Simões BM, Clarke RB, Evans DG, Ghezelayagh TS, Ponandai-Srinivasan S, Boggavarapu NR, Lalitkumar PG, Howell SJ, Risques RA, Rådestad AF, Dubeau L, Gemzell-Danielsson K, Widschwendter M. PMID: 35854342; PMCID: PMC9295457.
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PubMed Mentions: Fields:
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Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women. Genome Med. 2022 06 15; 14(1):64.
Bartlett TE, Evans I, Jones A, Barrett JE, Haran S, Reisel D, Papaikonomou K, Jones L, Herzog C, Pashayan N, Simões BM, Clarke RB, Evans DG, Ghezelayagh TS, Ponandai-Srinivasan S, Boggavarapu NR, Lalitkumar PG, Howell SJ, Risques RA, Rådestad AF, Dubeau L, Gemzell-Danielsson K, Widschwendter M. PMID: 35701800; PMCID: PMC9199133.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis. Oncogene. 2021 05; 40(20):3624-3632.
Rangel DF, Dubeau L, Park R, Chan P, Ha DP, Pulido MA, Mullen DJ, Vorobyova I, Zhou B, Borok Z, Offringa IA, Lee AS. PMID: 33931739; PMCID: PMC8179725.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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A Phosphotyrosine Switch in Estrogen Receptor β Is Required for Mouse Ovarian Function. Front Cell Dev Biol. 2021; 9:649087.
Yuan B, Yang J, Dubeau L, Hu Y, Li R. PMID: 33898441; PMCID: PMC8063698.
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PubMed Mentions:
1
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First reported case of BRAF V600E mutation in T-cell prolymphocytic leukaemia. Br J Haematol. 2020 10; 191(2):e52-e55.
Dong S, Khedro T, Ward P, Dubeau L, Yaghmour B, Siddiqi I, Yaghmour G. PMID: 32712959; PMCID: PMC9007147.
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Translation:
Humans
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Non-Surgical Cancer Risk Reduction in BRCA1 Mutation Carriers: Disabling the Remote Control. Cancers (Basel). 2020 Feb 27; 12(3).
Widschwendter M, Dubeau L. PMID: 32120796; PMCID: PMC7139938.
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PubMed Mentions:
1
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Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma. Sci Rep. 2020 02 07; 10(1):2160.
Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N. PMID: 32034256; PMCID: PMC7005787.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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View in:
PubMed Mentions:
1 Fields:
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Mechanism of cytokinesis failure in ovarian cystadenomas with defective BRCA1 and P53 pathways. Int J Cancer. 2018 12 01; 143(11):2932-2942.
Austria T, Marion C, Yu V, Widschwendter M, Hinton DR, Dubeau L. PMID: 29978915; PMCID: PMC6235723.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes. Clin Epigenetics. 2018 07 20; 10(1):98.
Gao L, Liu X, Millstein J, Siegmund KD, Dubeau L, Maguire RL, Jim Zhang J, Fuemmeler BF, Kollins SH, Hoyo C, Murphy SK, Breton CV. PMID: 30029617; PMCID: PMC6054742.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer. Oncotarget. 2017 Nov 28; 8(61):103543-103556.
Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N. PMID: 29262583; PMCID: PMC5732749.
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PubMed Mentions:
25 Fields:
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GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice. Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4020-E4029.
Shen J, Ha DP, Zhu G, Rangel DF, Kobielak A, Gill PS, Groshen S, Dubeau L, Lee AS. PMID: 28461470; PMCID: PMC5441757.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 02 01; 7:40919.
Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. PMID: 28145503; PMCID: PMC5286507.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer. Oncotarget. 2017 Jan 17; 8(3):3811-3825.
Kiechl S, Schramek D, Widschwendter M, Fourkala EO, Zaikin A, Jones A, Jaeger B, Rack B, Janni W, Scholz C, Willeit J, Weger S, Mayr A, Teschendorff A, Rosenthal A, Fraser L, Philpott S, Dubeau L, Keshtgar M, Roylance R, Jacobs IJ, Menon U, Schett G, Penninger JM. PMID: 28002811; PMCID: PMC5354797.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution. Nat Commun. 2016 05 24; 7:11620.
Bartlett TE, Chindera K, McDermott J, Breeze CE, Cooke WR, Jones A, Reisel D, Karegodar ST, Arora R, Beck S, Menon U, Dubeau L, Widschwendter M. PMID: 27216078; PMCID: PMC4890182.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget. 2016 Mar 22; 7(12):14885-97.
Shen J, Yao L, Lin YG, DeMayo FJ, Lydon JP, Dubeau L, Lee AS. PMID: 26910913; PMCID: PMC4924759.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. Genome Med. 2015 Oct 24; 7:108.
Teschendorff AE, Lee SH, Jones A, Fiegl H, Kalwa M, Wagner W, Chindera K, Evans I, Dubeau L, Orjalo A, Horlings HM, Niederreiter L, Kaser A, Yang W, Goode EL, Fridley BL, Jenner RG, Berns EM, Wik E, Salvesen HB, Wisman GB, van der Zee AG, Davidson B, Trope CG, Lambrechts S, Vergote I, Calvert H, Jacobs IJ, Widschwendter M. PMID: 26497652; PMCID: PMC4619324.
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PubMed Mentions:
88 Fields:
Translation:
HumansCells
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Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent. PLoS One. 2015; 10(10):e0139013.
Liu Y, Pike MC, Wu N, Lin YG, Mucowski S, Punj V, Tang Y, Yen HY, Stanczyk FZ, Enbom E, Austria T, Widschwendter M, Maxson R, Dubeau L. PMID: 26488398; PMCID: PMC4619541.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State. EBioMedicine. 2015 Oct; 2(10):1318-30.
Liu Y, Yen HY, Austria T, Pettersson J, Peti-Peterdi J, Maxson R, Widschwendter M, Dubeau L. PMID: 26629527; PMCID: PMC4634618.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers. EBioMedicine. 2015 Oct; 2(10):1331-9.
Widschwendter M, Burnell M, Fraser L, Rosenthal AN, Philpott S, Reisel D, Dubeau L, Cline M, Pan Y, Yi PC, Gareth Evans D, Jacobs IJ, Menon U, Wood CE, Dougall WC. PMID: 26629528; PMCID: PMC4634624.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimals
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A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99.
Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. PMID: 26094889; PMCID: PMC4509734.
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PubMed Mentions:
389 Fields:
Translation:
HumansAnimals
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Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications. Transl Cancer Res. 2015 Feb; 4(1):3-13.
Dubeau L. PMID: 26568913; PMCID: PMC4643277.
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PubMed Mentions:
6
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Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789.
Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles BL, Johnson DL. PMID: 25502566; PMCID: PMC4263377.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol Cancer Ther. 2014 Aug; 13(8):2004-17.
Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, Schönthal AH, Hofman FM, Chen TC. PMID: 24994771.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Coming into focus: the nonovarian origins of ovarian cancer. Ann Oncol. 2013 Nov; 24 Suppl 8:viii28-viii35.
Dubeau L, Drapkin R. PMID: 24131966; PMCID: PMC3805308.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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The sex hormone system in carriers of BRCA1/2 mutations: a case-control study. Lancet Oncol. 2013 Nov; 14(12):1226-32.
Widschwendter M, Rosenthal AN, Philpott S, Rizzuto I, Fraser L, Hayward J, Intermaggio MP, Edlund CK, Ramus SJ, Gayther SA, Dubeau L, Fourkala EO, Zaikin A, Menon U, Jacobs IJ. PMID: 24140203.
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PubMed Mentions:
75 Fields:
Translation:
Humans
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The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol Oncol. 2013 Mar; 128(3):552-9.
Matsuo K, Gray MJ, Yang DY, Srivastava SA, Tripathi PB, Sonoda LA, Yoo EJ, Dubeau L, Lee AS, Lin YG. PMID: 23200913; PMCID: PMC4199224.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs. Lab Invest. 2012 Jun; 92(6):802-11.
Yen HY, Gabet Y, Liu Y, Martin A, Wu NL, Pike MC, Frenkel B, Maxson R, Dubeau L. PMID: 22488153; PMCID: PMC4530993.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. PLoS One. 2011; 6(12):e28141.
Campan M, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, Dubeau L, Siegmund KD, Wu AH, Groshen S, Chandavarkar U, Roman LD, Berchuck A, Pearce CL, Laird PW. PMID: 22163280; PMCID: PMC3233546.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells. Int J Cancer. 2012 Jun 01; 130(11):2495-504.
Yu VM, Marion CM, Austria TM, Yeh J, Schönthal AH, Dubeau L. PMID: 21792894; PMCID: PMC3299830.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Pathological characteristics of BRCA-associated breast cancers in Hispanics. Breast Cancer Res Treat. 2011 Nov; 130(1):281-9.
Lagos-Jaramillo VI, Press MF, Ricker CN, Dubeau L, Mai PL, Weitzel JN. PMID: 21604016; PMCID: PMC3526343.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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BRCA genes: lessons learned from experimental and clinical cancer. Ann Oncol. 2011 Jan; 22 Suppl 1:i7-10.
Muggia F, Safra T, Dubeau L. PMID: 21285156.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer. Cancer Res. 2010 Jan 01; 70(1):221-8.
Hong H, Yen HY, Brockmeyer A, Liu Y, Chodankar R, Pike MC, Stanczyk FZ, Maxson R, Dubeau L. PMID: 20028858; PMCID: PMC2805040.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study. Int J Cancer. 2009 Nov 01; 125(9):2214-8.
Widschwendter M, Apostolidou S, Jones AA, Fourkala EO, Arora R, Pearce CL, Frasco MA, Ayhan A, Zikan M, Cibula D, Iyibozkurt CA, Yavuz E, Hauser-Kronberger C, Dubeau L, Menon U, Jacobs IJ. PMID: 19621443.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 2010 Mar; 17(3):488-98.
Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, Fu Y, Luo B, Dubeau L, Hinton DR, Lee AS. PMID: 19816510; PMCID: PMC2822118.
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PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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Hemimethylation footprints of DNA demethylation in cancer. Epigenetics. 2009 Apr 01; 4(3):165-75.
Shao C, Lacey M, Dubeau L, Ehrlich M. PMID: 19287214.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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The cell of origin of ovarian epithelial tumours. Lancet Oncol. 2008 Dec; 9(12):1191-7.
Dubeau L. PMID: 19038766; PMCID: PMC4176875.
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PubMed Mentions:
154 Fields:
Translation:
HumansAnimals
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Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. J Biol Chem. 2008 Jul 11; 283(28):19184-91.
Johnson SA, Dubeau L, Johnson DL. PMID: 18456653; PMCID: PMC2443659.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
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Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila). 2008 Sep; 1(4):233-40.
Yoo CB, Chuang JC, Byun HM, Egger G, Yang AS, Dubeau L, Long T, Laird PW, Marquez VE, Jones PA. PMID: 19138966; PMCID: PMC6959547.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res. 2008 Jan 15; 68(2):498-505.
Dong D, Ni M, Li J, Xiong S, Ye W, Virrey JJ, Mao C, Ye R, Wang M, Pen L, Dubeau L, Groshen S, Hofman FM, Lee AS. PMID: 18199545.
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PubMed Mentions:
196 Fields:
Translation:
Animals
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BRCA1-induced ovarian oncogenesis. Adv Exp Med Biol. 2008; 622:89-97.
Dubeau L. PMID: 18546621.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Increased chromosomal stability in cultures of ovarian tumours of low malignant potential compared to cystadenomas. Br J Cancer. 2007 Jun 18; 96(12):1908-13.
Yu J, Roy D, Brockmeyer AD, Dubeau L. PMID: 17519898; PMCID: PMC2359981.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain. Hum Mol Genet. 2007 May 15; 16(10):1133-42.
Shelbourne PF, Keller-McGandy C, Bi WL, Yoon SR, Dubeau L, Veitch NJ, Vonsattel JP, Wexler NS, US-Venezuela Collaborative Research Group, Arnheim N, Augood SJ. PMID: 17409200.
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PubMed Mentions:
107 Fields:
Translation:
HumansAnimalsCells
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The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome. Br J Cancer. 2007 Apr 10; 96(7):1083-91.
Kumar SR, Masood R, Spannuth WA, Singh J, Scehnet J, Kleiber G, Jennings N, Deavers M, Krasnoperov V, Dubeau L, Weaver FA, Sood AK, Gill PS. PMID: 17353927; PMCID: PMC2360128.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. Oncogene. 2006 Apr 27; 25(18):2636-45.
Ehrlich M, Woods CB, Yu MC, Dubeau L, Yang F, Campan M, Weisenberger DJ, Long T, Youn B, Fiala ES, Laird PW. PMID: 16532039; PMCID: PMC1449872.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6.
Li YF, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. PMID: 16456144; PMCID: PMC2662916.
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PubMed Mentions:
36 Fields:
Translation:
HumansCellsPHPublic Health
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TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1563-8.
Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. PMID: 16166621; PMCID: PMC2718456.
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PubMed Mentions:
6 Fields:
Translation:
HumansPHPublic Health
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Intercellular adhesion molecule-1 and childhood asthma. Hum Genet. 2005 Sep; 117(5):476-84.
Li YF, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. PMID: 16021473.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. Genes Chromosomes Cancer. 2005 May; 43(1):11-24.
Grunau C, Sanchez C, Ehrlich M, van der Bruggen P, Hindermann W, Rodriguez C, Krieger S, Dubeau L, Fiala E, De Sario A. PMID: 15704127.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others. Cancer Biol Ther. 2005 Apr; 4(4):440-8.
Nishiyama R, Qi L, Tsumagari K, Weissbecker K, Dubeau L, Champagne M, Sikka S, Nagai H, Ehrlich M. PMID: 15846090.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. Curr Biol. 2005 Mar 29; 15(6):561-5.
Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen HY, Deng C, Pike MC, Shuler CF, Maxson R, Dubeau L. PMID: 15797026.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors. Hum Gene Ther. 2004 Jun; 15(6):553-61.
Dong D, Dubeau L, Bading J, Nguyen K, Luna M, Yu H, Gazit-Bornstein G, Gordon EM, Gomer C, Hall FL, Gambhir SS, Lee AS. PMID: 15212714.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Detection of residual subclinical ovarian carcinoma after completion of adjuvant chemotherapy. Clin Cancer Res. 2004 Apr 15; 10(8):2681-6.
Nouriani M, Bahador A, Berek JS, Cheng JP, Chi DS, Cliby WA, Del Priore G, Dodson MK, Duggan BD, Gershenson DM, Lentz SE, Penson RT, Robinson WR, Rodriguez M, Roman LD, Yu MC, Zempolich K, Dubeau L. PMID: 15102671.
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PubMed Mentions: Fields:
Translation:
Humans
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Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone. Mol Carcinog. 2003 Dec; 38(4):160-9.
Blumenthal M, Kardosh A, Dubeau L, Borok Z, Schönthal AH. PMID: 14639655.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells. Cancer Res. 2003 Sep 15; 63(18):5813-20.
Velicescu M, Yu J, Herbert BS, Shay JW, Granada E, Dubeau L. PMID: 14522904.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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The TATA-binding protein as a regulator of cellular transformation. Cell Cycle. 2003 Sep-Oct; 2(5):442-4.
Johnson SA, Dubeau L, White RJ, Johnson DL. PMID: 12963838.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Huntington disease expansion mutations in humans can occur before meiosis is completed. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8834-8.
Yoon SR, Dubeau L, de Young M, Wexler NS, Arnheim N. PMID: 12857955; PMCID: PMC166399.
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PubMed Mentions:
48 Fields:
Translation:
HumansCells
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Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis. Mol Cell Biol. 2003 May; 23(9):3043-51.
Johnson SA, Dubeau L, Kawalek M, Dervan A, Schönthal AH, Dang CV, Johnson DL. PMID: 12697807; PMCID: PMC153209.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages. Cancer Res. 2002 Dec 15; 62(24):7207-12.
Reddy RK, Dubeau L, Kleiner H, Parr T, Nichols P, Ko B, Dong D, Ko H, Mao C, DiGiovanni J, Lee AS. PMID: 12499260.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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p53: a key player in the telomere dynamics. Cancer Biol Ther. 2002 Sep-Oct; 1(5):518-9.
Velicescu M, Dubeau L. PMID: 12496480.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth. Am J Respir Crit Care Med. 2002 Sep 01; 166(5):710-6.
Gilliland FD, Gauderman WJ, Vora H, Rappaport E, Dubeau L. PMID: 12204870.
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PubMed Mentions:
52 Fields:
Translation:
Humans
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Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63.
Gilliland FD, Li YF, Dubeau L, Berhane K, Avol E, McConnell R, Gauderman WJ, Peters JM. PMID: 12186820.
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PubMed Mentions:
89 Fields:
Translation:
HumansPHPublic Health
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Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51.
Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. PMID: 12153968.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activity. Cancer Biol Ther. 2002 May-Jun; 1(3):300-6.
Zhou H, Luo MP, Schönthal AH, Pike MC, Stallcup MR, Blumenthal M, Zheng W, Dubeau L. PMID: 12432283.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Effect of reproductive hormones on ovarian epithelial tumors: II. Effect on angiogenic activity. Cancer Biol Ther. 2002 May-Jun; 1(3):307-12.
Chen C, Petitclerc E, Zhou H, Brooks PC, Sun T, Yu MC, Zheng W, Dubeau L. PMID: 12432284.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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Telomerase and malignant transformation. Cancer Treat Res. 2002; 107:213-28.
Yu J, Dubeau L. PMID: 11775451.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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Collection of buccal cell DNA in seventh-grade children using water and a toothbrush. Cancer Epidemiol Biomarkers Prev. 2001 Nov; 10(11):1227-30.
London SJ, Xia J, Lehman TA, Yang JH, Granada E, Chunhong L, Dubeau L, Li T, David-Beabes GL, Li Y. PMID: 11700274.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Ovarian tumor development: insights from ovarian embryogenesis. Eur J Gynaecol Oncol. 2001; 22(3):175-83.
Rodriguez M, Dubeau L. PMID: 11501768.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Conseusus statements on prognostic factors in epithelial ovarian carcinoma. Report of the Consensus Meeting organized by the European Society of Gynaecological Oncology, ESGO. Eur J Gynaecol Oncol. 2000; 21(5):513-26.
Bösze P, Bast RC, Berchuck A, Burke HB, Buller RE, Creasman WT, Dubeau L, Fox H, Geisler HE, Geisler JP, Henson DE, Rustin GJ, Vermorken JB, Wells M, Wilbanks GD. PMID: 11198047.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes? Gynecol Oncol. 1999 Mar; 72(3):437-42.
Dubeau L. PMID: 10053122.
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PubMed Mentions:
77 Fields:
Translation:
Humans
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Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25. Oncogene. 1999 Feb 25; 18(8):1545-51.
Wan M, Sun T, Vyas R, Zheng J, Granada E, Dubeau L. PMID: 10102624.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential. Mutat Res. 1999 Jan 25; 423(1-2):91-101.
Qu G, Dubeau L, Narayan A, Yu MC, Ehrlich M. PMID: 10029684.
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PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Differences in p16 gene methylation and expression in benign and malignant ovarian tumors. Gynecol Oncol. 1999 Jan; 72(1):87-92.
McCluskey LL, Chen C, Delgadillo E, Felix JC, Muderspach LI, Dubeau L. PMID: 9889036.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Genetics and biology of gynecologic cancer. Curr Opin Oncol. 1998 Sep; 10(5):439-46.
Duggan BD, Dubeau L. PMID: 9800115.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Detection of ovarian cancer cells: comparison of a telomerase assay and cytologic examination. J Natl Cancer Inst. 1998 Feb 04; 90(3):238-42.
Duggan BD, Wan M, Yu MC, Roman LD, Muderspach LI, Delgadillo E, Li WZ, Martin SE, Dubeau L. PMID: 9462682.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Telomerase and cancer management: silver bullet or fool's gold? Gynecol Oncol. 1998 Feb; 68(2):143-4.
Zempolich KA, Dubeau L. PMID: 9514814.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Establishment of long-term in vitro cultures of human ovarian cystadenomas and LMP tumors and examination of their spectrum of expression of matrix-degrading proteinases. Gynecol Oncol. 1997 Dec; 67(3):277-84.
Luo MP, Gomperts B, Imren S, DeClerck YA, Ito M, Velicescu M, Felix JC, Dubeau L. PMID: 9441775.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Biology of ovarian cancer. Curr Opin Oncol. 1997 Sep; 9(5):465-70.
McCluskey LL, Dubeau L. PMID: 9327225.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Telomerase activity in benign and malignant epithelial ovarian tumors. J Natl Cancer Inst. 1997 Mar 19; 89(6):437-41.
Wan M, Li WZ, Duggan BD, Felix JC, Zhao Y, Dubeau L. PMID: 9091645.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis. Br J Cancer. 1997; 75(3):396-402.
Cheng P, Schmutte C, Cofer KF, Felix JC, Yu MC, Dubeau L. PMID: 9020485; PMCID: PMC2063379.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer. Br J Cancer. 1996 Jun; 73(11):1398-400.
Wan M, Cofer KF, Dubeau L. PMID: 8645586; PMCID: PMC2074480.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Potential role of the inactivated X chromosome in ovarian epithelial tumor development. J Natl Cancer Inst. 1996 Apr 17; 88(8):510-8.
Cheng PC, Gosewehr JA, Kim TM, Velicescu M, Wan M, Zheng J, Felix JC, Cofer KF, Luo P, Biela BH, Godorov G, Dubeau L. PMID: 8606379.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer. 1995 Aug 22; 64(4):280-5.
Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan M, Dubeau L, Scambia G, Masciullo V, Ferrandina G, Benedetti Panici P, Mancuso S, Neri G, Testa JR. PMID: 7657393.
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PubMed Mentions:
245 Fields:
Translation:
Humans
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Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas. J Natl Cancer Inst. 1995 Aug 02; 87(15):1146-53.
Zheng J, Benedict WF, Xu HJ, Hu SX, Kim TM, Velicescu M, Wan M, Cofer KF, Dubeau L. PMID: 7674319.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas. Int J Oncol. 1994 Nov; 5(5):1043-8.
Wan M, Zweizig S, Dablaing G, Zheng J, Velicescu M, Dubeau L. PMID: 21559678.
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PubMed Mentions:
4 Fields:
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Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression. Cancer Res. 1994 Feb 01; 54(3):605-9.
Kim TM, Benedict WF, Xu HJ, Hu SX, Gosewehr J, Velicescu M, Yin E, Zheng J, D'Ablaing G, Dubeau L. PMID: 8306317.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Histologically benign or low-grade malignant tumors adjacent to high-grade ovarian carcinomas contain molecular characteristics of high-grade carcinomas. Cancer Res. 1993 Sep 15; 53(18):4138-42.
Zheng J, Wan M, Zweizig S, Velicescu M, Yu MC, Dubeau L. PMID: 8364906.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p15.5 in ovarian tumorigenesis. Int J Oncol. 1992 Jul; 1(2):215-9.
Friedman R, Velicescu M, Dubeau L. PMID: 21584534.
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Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification. Cancer Res. 1991 Aug 01; 51(15):4045-51.
Zheng JP, Robinson WR, Ehlen T, Yu MC, Dubeau L. PMID: 1677312.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Culture of human fetal ovarian epithelium in a chemically-defined, serum-free medium: a model for ovarian carcinogenesis. Anticancer Res. 1990 Sep-Oct; 10(5A):1233-40.
Dubeau L, Velicescu M, Sherrod AE, Schreiber G, Holt G. PMID: 1700663.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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C-myc proto-oncogene amplification detected by polymerase chain reaction in archival human ovarian carcinomas. Am J Pathol. 1990 Sep; 137(3):653-8.
Schreiber G, Dubeau L. PMID: 2205100; PMCID: PMC1877513.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Mechanisms of human bladder tumor invasion: role of protease cathepsin B. J Urol. 1990 Sep; 144(3):798-804.
Weiss RE, Liu BC, Ahlering T, Dubeau L, Droller MJ. PMID: 2201799.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Rapid degradation of extracellular matrix proteins by normal human uroepithelial cells. Cancer Res. 1990 Mar 15; 50(6):1897-904.
Allen LE, Dubeau L, Alvarez O, Jones PA. PMID: 2407347.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas. Oncogene. 1990 Feb; 5(2):219-23.
Ehlen T, Dubeau L. PMID: 2320374.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Human decidua is a major source of renin. J Clin Invest. 1989 Jun; 83(6):2085-92.
Shaw KJ, Do YS, Kjos S, Anderson PW, Shinagawa T, Dubeau L, Hsueh WA. PMID: 2656762; PMCID: PMC303935.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Detection of ras point mutations by polymerase chain reaction using mutation-specific, inosine-containing oligonucleotide primers. Biochem Biophys Res Commun. 1989 Apr 28; 160(2):441-7.
Ehlen T, Dubeau L. PMID: 2655589.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Lymphocyte gene rearrangement studies in formalin-fixed, paraffin-embedded pathology specimens. West J Med. 1988 Nov; 149(5):596.
Dubeau L. PMID: 18750496; PMCID: PMC1026545.
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PubMed Mentions: Fields:
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Differential regulation of plasminogen activators by epidermal growth factor in normal and neoplastic human urothelium. Cancer Res. 1988 Oct 01; 48(19):5552-6.
Dubeau L, Jones PA, Rideout WM, Laug WE. PMID: 3138024.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Studies on immunoglobulin gene rearrangement in formalin-fixed, paraffin-embedded pathology specimens. Am J Pathol. 1988 Mar; 130(3):588-94.
Dubeau L, Weinberg K, Jones PA, Nichols PW. PMID: 3126662; PMCID: PMC1880675.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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A new in vivo model to study invasion and metastasis of human bladder carcinoma. Cancer Res. 1987 Dec 15; 47(24 Pt 1):6660-5.
Ahlering TE, Dubeau L, Jones PA. PMID: 3677100.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Growth of normal and neoplastic urothelium and response to epidermal growth factor in a defined serum-free medium. Cancer Res. 1987 Apr 15; 47(8):2107-12.
Dubeau L, Jones PA. PMID: 3493840.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Southern blot analysis of DNA extracted from formalin-fixed pathology specimens. Cancer Res. 1986 Jun; 46(6):2964-9.
Dubeau L, Chandler LA, Gralow JR, Nichols PW, Jones PA. PMID: 3009004.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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Long-term effects of pulmonary shrapnel injury. Report of a case with carcinoma and residual shrapnel tract. Arch Pathol Lab Med. 1984 May; 108(5):407-9.
Dubeau L, Fraser RS. PMID: 6546865.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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The mechanism of replication of phi X 174. XVIII. Gene A and A* proteins of phi X 174 bind tightly to phi X 174 replicative form DNA. Biochim Biophys Acta. 1981 Mar 26; 653(1):52-60.
Dubeau L, Denhardt DT. PMID: 6261820.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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The mechanism of replication of phiX174. XVII. Purification and partial characterization of the gene A and A proteins. Can J Biochem. 1981 Feb; 59(2):106-15.
Dubeau L, Hours C, Denhardt DT. PMID: 6453639.
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Cells