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Beiyun Zhou, PhD

Title(s)Associate Professor of Medicine
AddressHMR 911
Health Sciences Campus
Los Angeles CA 90089-9099
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    Collapse Biography 
    Collapse Education and Training
    University of Southern California, Los AngelesPh.D05/2018Molecular Pharmacology and Toxicology
    Institute of Plant Physiology and Ecology,Chinese Academy of Sciences , ShanghaiM.S07/1988Microbiology

    Collapse Overview 
    Collapse Overview
    Dr. Zhou’s research focuses on the delineation of mechanisms regulating alveolar epithelial cell (AEC) function, differentiation and plasticity in the context of lung injury and repair. A major focus has been to elucidate pathways (e.g., Hippo/YAP, Wnt/B-catenin, TGF-B/Smad, Forkhead box (Fox) and GATA6) as well as transcriptomic and epigenomic regulations that control differentiation of the alveolar epithelium (including pulmonary stem/progenitor cell proliferation/differentiation) in order to understand how they are altered in disease and injury. Her current studies engaged in to investigate the role of endoplasmic reticulum (ER) stress and the ER master regulator GRP78 in AEC abnormalities in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) using AEC-specific Grp78 knockout mice model. Her goal is to examine signaling pathways that modulate aberrant epithelial-mesenchymal interactions underlying ER stress-mediated fibrosis and identify new therapeutic approaches for pulmonary fibrosis.

    Collapse Research 
    Collapse Research Activities and Funding
    Epithelial abnormalities in IPF: role of ER stress and GRP78/BiP
    NIH/NHLBI R01HL114959Aug 1, 2013 - Jun 30, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2020 Jul 01; 319(1):L173-L184. Castaldi A, Horie M, Rieger ME, Dubourd M, Sunohara M, Pandit K, Zhou B, Offringa IA, Marconett CN, Borok Z. PMID: 32432919.
      View in: PubMed   Mentions: 1     Fields:    
    2. WNT5a-ROR Signaling Is Essential for Alveologenesis. Cells. 2020 Feb 07; 9(2). Li C, Smith SM, Peinado N, Gao F, Li W, Lee MK, Zhou B, Bellusci S, Pryhuber GS, Ho HH, Borok Z, Minoo P. PMID: 32046118.
      View in: PubMed   Mentions:    Fields:    
    3. LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response. Cancer Res. 2019 Jun 15; 79(12):3050-3062. Shahabi S, Kumaran V, Castillo J, Cong Z, Nandagopal G, Mullen DJ, Alvarado A, Correa MR, Saizan A, Goel R, Bhat A, Lynch SK, Zhou B, Borok Z, Marconett CN. PMID: 30796052.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    4. CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. Luo J, Chimge NO, Zhou B, Flodby P, Castaldi A, Firth AL, Liu Y, Wang H, Yang C, Marconett CN, Crandall ED, Offringa IA, Frenkel B, Borok Z. PMID: 30325015.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes. Epigenomics. 2018 09; 10(9):1167-1187. Yang C, Stueve TR, Yan C, Rhie SK, Mullen DJ, Luo J, Zhou B, Borok Z, Marconett CN, Offringa IA. PMID: 30212242.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation. Sci Rep. 2017 06 14; 7(1):3473. Flodby P, Li C, Liu Y, Wang H, Rieger ME, Minoo P, Crandall ED, Ann DK, Borok Z, Zhou B. PMID: 28615712.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Region-specific role for Pten in maintenance of epithelial phenotype and integrity. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall ED, Minoo P, Borok Z. PMID: 27864284.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. J Natl Cancer Inst. 2016 12; 108(12). Zuber V, Marconett CN, Shi J, Hua X, Wheeler W, Yang C, Song L, Dale AM, Laplana M, Risch A, Witoelar A, Thompson WK, Schork AJ, Bettella F, Wang Y, Djurovic S, Zhou B, Borok Z, van der Heijden HF, de Graaf J, Swinkels D, Aben KK, McKay J, Hung RJ, Bikeböller H, Stevens VL, Albanes D, Caporaso NE, Han Y, Wei Y, Panadero MA, Mayordomo JI, Christiani DC, Kiemeney L, Andreassen OA, Houlston R, Amos CI, Chatterjee N, Laird-Offringa IA, Mills IG, Landi MT. PMID: 27565901.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. Am J Respir Cell Mol Biol. 2016 07; 55(1):135-49. Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B. PMID: 26816051.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. The importance of detailed epigenomic profiling of different cell types within organs. Epigenomics. 2016 06; 8(6):817-29. Stueve TR, Marconett CN, Zhou B, Borok Z, Laird-Offringa IA. PMID: 27305639.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z. PMID: 26833564.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    12. Transforming Growth Factor-ß1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E. Sci Rep. 2015 Dec 18; 5:18233. Smith KA, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, Okon A, Hergert P, Braziunas J, Wagner CR, Borok Z, Bitterman PB. PMID: 26678431.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    13. Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. Liebler JM, Marconett CN, Juul N, Wang H, Liu Y, Flodby P, Laird-Offringa IA, Minoo P, Zhou B. PMID: 26545903.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat. Genom Data. 2014 Dec 01; 2:105-109. Marconett CN, Zhou B, Siegmund KD, Borok Z, Laird-Offringa IA. PMID: 25343132.
      View in: PubMed   Mentions:
    15. TRIM72 is required for effective repair of alveolar epithelial cell wounding. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L449-59. Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali SN, Takeshima H, Hubmayr RD, Zhao X. PMID: 25106429.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. PMID: 24588076.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    17. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun. 2014 Feb 27; 5:3365. Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Freedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT. PMID: 24572595.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    18. Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet. 2013 Jun; 9(6):e1003513. Marconett CN, Zhou B, Rieger ME, Selamat SA, Dubourd M, Fang X, Lynch SK, Stueve TR, Siegmund KD, Berman BP, Borok Z, Laird-Offringa IA. PMID: 23818859.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    19. Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2. PLoS One. 2013; 8(1):e53342. Wu H, Chen L, Zhang X, Zhou Q, Li JM, Berger S, Borok Z, Zhou B, Xiao Z, Yin H, Liu M, Wang Y, Jin J, Blackburn MR, Xia Y, Zhang W. PMID: 23326416.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    20. GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol. 2012 Dec; 227(12):3803-11. Pfaffenbach KT, Pong M, Morgan TE, Wang H, Ott K, Zhou B, Longo VD, Lee AS. PMID: 22422508.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. Troglitazone attenuates TGF-ß1-induced EMT in alveolar epithelial cells via a PPAR?-independent mechanism. PLoS One. 2012; 7(6):e38827. Zhou B, Buckley ST, Patel V, Liu Y, Luo J, Krishnaveni MS, Ivan M, DeMaio L, Kim KJ, Ehrhardt C, Crandall ED, Borok Z. PMID: 22745681.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    22. Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem. 2012 Mar 02; 287(10):7026-38. Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z. PMID: 22241478.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    23. Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. DeMaio L, Buckley ST, Krishnaveni MS, Flodby P, Dubourd M, Banfalvi A, Xing Y, Ehrhardt C, Minoo P, Zhou B, Crandall ED, Borok Z. PMID: 21984393.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    24. Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, Banfalvi A, Krishnaveni MS, Dubourd M, Demaio L, Willis BC, Kim KJ, duBois RM, Crandall ED, Beers MF, Borok Z. PMID: 21169555.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    25. Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan; 121(1):277-87. Li M, Krishnaveni MS, Li C, Zhou B, Xing Y, Banfalvi A, Li A, Lombardi V, Akbari O, Borok Z, Minoo P. PMID: 21135509.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    26. Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14309-14. Henderson WR, Chi EY, Ye X, Nguyen C, Tien YT, Zhou B, Borok Z, Knight DA, Kahn M. PMID: 20660310.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    27. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. Flodby P, Borok Z, Banfalvi A, Zhou B, Gao D, Minoo P, Ann DK, Morrisey EE, Crandall ED. PMID: 19767448.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    28. Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall ED, Borok Z. PMID: 18448628.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z. PMID: 18239190.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. Flodby P, Zhou B, Ann DK, Kim KJ, Minoo P, Crandall ED, Borok Z. PMID: 17339032.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice. Eur J Oral Sci. 2007 Feb; 115(1):30-9. Lin HH, Xiong Y, Ho YS, Zhou B, Nguyen HV, Deng H, Lee R, Yen Y, Borok Z, Ann DK. PMID: 17305714.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    32. Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. Zhou B, Ann DK, Li X, Kim KJ, Lin H, Minoo P, Crandall ED, Borok Z. PMID: 17108010.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    33. Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol (1985). 2005 Jan; 98(1):322-8. Chen SP, Zhou B, Willis BC, Sandoval AJ, Liebler JM, Kim KJ, Ann DK, Crandall ED, Borok Z. PMID: 15361518.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    34. Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2. J Histochem Cytochem. 2004 Jun; 52(6):759-67. Liebler JM, Borok Z, Li X, Zhou B, Sandoval AJ, Kim KJ, Crandall ED. PMID: 15150284.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    35. Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. Qiao R, Zhou B, Harboe-Schmidt E, Kasahara N, Kim KJ, Liebler JM, Crandall ED, Borok Z. PMID: 15144576.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Identification of three genes of known function expressed by alveolar epithelial type I cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. Qiao R, Zhou B, Liebler JM, Li X, Crandall ED, Borok Z. PMID: 12600825.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    37. Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim KJ, Crandall ED. PMID: 11880284.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
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