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Edward David Crandall, PhD, MD

Title(s)Professor of Medicine
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    Other Positions
    Title(s)Hastings Foundation Professorship in Medicine


    Collapse Biography 
    Collapse Awards and Honors
    2005  - PresBest Doctors of America
    National Institutes of Health1987  - 1997MERIT Award
    National Institutes of Health1975  - 1980Research Career Development Award
    University of PennsylvaniaChair of Department of Medicine Scholarship
    U.S. Public Health ServiceSpecial Fellowship
    Royal E. Cabell Fellowship
    National Science FoundationGraduate Fellowship
    Union Carbide Fellowship
    Walter P. Murphy Fellowship
    New York StateRegents Scholarship

    Collapse Overview 
    Collapse Overview
    Dr. Crandall's research has been focused on the following topics: markers of alveolar epithelial cell development and differentiation, regulation of pulmonary epithelial cell differentiation, acute and chronic lung injury and the factors that influence recovery, transport properties of pulmonary alveolar epithelium, and biology of nanoparticle interactions with alveolar epithelial cells.

    Dr. Crandall received his B.Ch.E. from Cooper Union, his M.S. and Ph.D. in chemical engineering from Northwestern University, and his M.D. from the University of Pennsylvania. His training in internal medicine and pulmonary/critical care medicine was undertaken at the Hospital of the University of Pennsylvania.

    Collapse Research 
    Collapse Research Activities and Funding
    MAPGen Knowledge Base (MAPGenKB) and Coordination Center
    NIH/NHLBI U01HL108634Aug 25, 2011 - May 31, 2018
    Role: Co-Principal Investigator
    Interactions of engineered nanomaterials with lung alveolar epithelium
    NIH/NIEHS RC2ES018782Sep 25, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Nanoparticle properties and alveolar epithelial barrier/transport functions
    NIH/NIEHS R01ES017034Jun 15, 2009 - Mar 31, 2014
    Role: Principal Investigator
    Absorption mechanisms for peptide/protein drugs via lung
    NIH/NHLBI R01HL064365Sep 30, 1999 - Jul 31, 2010
    Role: Principal Investigator
    AT1 vs AT2 cells: differential roles in alveolar function and biology
    NIH/NHLBI R01HL038621Sep 1, 1986 - Jun 30, 2012
    Role: Principal Investigator
    GATA-6: Key Regulator of AEC Transdifferentiation
    NIH/NHLBI R01HL038578Sep 1, 1986 - Nov 30, 2008
    Role: Co-Principal Investigator
    LUNG EPITHELIAL TRANSPORT PROPERTIES AND ALVEOLAR EDEMA
    NIH/NHLBI R37HL038578Sep 1, 1986 - Aug 31, 1997
    Role: Principal Investigator
    DETERMINANTS OF LUNG AND TISSUE CO2 EXCHANGE AND TRANSPO
    NIH/NHLBI R01HL025669Aug 1, 1980 - Aug 31, 1986
    Role: Principal Investigator
    LUNG EPITHELIAL TRANSPORT PROPERTIES AND ALVEOLAR EDEMA
    NIH/NHLBI R01HL026223Aug 1, 1980 - Aug 31, 1986
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Luo J, Chimge NO, Zhou B, Flodby P, Castaldi A, Firth AL, Liu Y, Wang H, Yang C, Marconett CN, Crandall ED, Offringa IA, Frenkel B, Borok Z. CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. PMID: 30325015.
      View in: PubMed
    2. Sipos A, Kim KJ, Chow RH, Flodby P, Borok Z, Crandall ED. Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis. Am J Physiol Lung Cell Mol Physiol. 2018 Aug 01; 315(2):L286-L300. PMID: 29722567.
      View in: PubMed
    3. Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 Mar 01; 128(3):970-984. PMID: 29400695.
      View in: PubMed
    4. Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP. Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1016-L1029. PMID: 28839100.
      View in: PubMed
    5. Gukasyan HJ, Uchiyama T, Kim KJ, Ehrhardt C, Wu SK, Borok Z, Crandall ED, Lee VHL. Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2. Pharm Res. 2017 Dec; 34(12):2488-2497. PMID: 28831683.
      View in: PubMed
    6. Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017 Aug 01; 127(8):3136-3151. PMID: 28737509.
      View in: PubMed
    7. Flodby P, Li C, Liu Y, Wang H, Rieger ME, Minoo P, Crandall ED, Ann DK, Borok Z, Zhou B. Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation. Sci Rep. 2017 06 14; 7(1):3473. PMID: 28615712.
      View in: PubMed
    8. Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z. Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes. Am J Respir Cell Mol Biol. 2017 03; 56(3):310-321. PMID: 27749084.
      View in: PubMed
    9. Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall ED, Minoo P, Borok Z. Region-specific role for Pten in maintenance of epithelial phenotype and integrity. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. PMID: 27864284.
      View in: PubMed
    10. Agoro R, Piotet-Morin J, Palomo J, Michaudel C, Vigne S, Maillet I, Chenuet P, Guillou N, Le Bérichel J, Kisielow M, Flodby P, Borok Z, Crandall ED, Le Bert M, Quesniaux V, Muller M, Di Padova F, Ryffel B, Gabay C, Couturier-Maillard A. IL-1R1-MyD88 axis elicits papain-induced lung inflammation. Eur J Immunol. 2016 11; 46(11):2531-2541. PMID: 27569535.
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    11. Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED. Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 09; 55(3):395-406. PMID: 27064541.
      View in: PubMed
    12. Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z. p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. PMID: 26833564.
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    13. Catalán MA, Kondo Y, Peña-Munzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2263-8. PMID: 25646474.
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    14. Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z. Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 01; 307(7):L524-36. PMID: 25106430.
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    15. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. PMID: 24588076.
      View in: PubMed
    16. Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, Sun F, Waterman M, Chen JJ, Chaudhary PM, Loscalzo J, Crandall E, Zhou XJ. DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. PMID: 24895436.
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    17. Negoda A, Kim KJ, Crandall ED, Worden RM. Polystyrene nanoparticle exposure induces ion-selective pores in lipid bilayers. Biochim Biophys Acta. 2013 Sep; 1828(9):2215-22. PMID: 23747366.
      View in: PubMed
    18. Xia T, Hamilton RF, Bonner JC, Crandall ED, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A. Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium. Environ Health Perspect. 2013 Jun; 121(6):683-90. PMID: 23649538; PMCID: PMC3672931.
    19. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. PMID: 23454523.
      View in: PubMed
    20. Zhou B, Buckley ST, Patel V, Liu Y, Luo J, Krishnaveni MS, Ivan M, DeMaio L, Kim KJ, Ehrhardt C, Crandall ED, Borok Z. Troglitazone attenuates TGF-ß1-induced EMT in alveolar epithelial cells via a PPAR?-independent mechanism. PLoS One. 2012; 7(6):e38827. PMID: 22745681.
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    21. Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z. Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem. 2012 Mar 02; 287(10):7026-38. PMID: 22241478.
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    22. DeMaio L, Buckley ST, Krishnaveni MS, Flodby P, Dubourd M, Banfalvi A, Xing Y, Ehrhardt C, Minoo P, Zhou B, Crandall ED, Borok Z. Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. PMID: 21984393.
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    23. Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57. PMID: 22131830.
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    24. Yacobi NR, Fazllolahi F, Kim YH, Sipos A, Borok Z, Kim KJ, Crandall ED. Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles. Air Qual Atmos Health. 2011 Mar 01; 4(1):65-78. PMID: 25568662.
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    25. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. PMID: 21310266.
      View in: PubMed
    26. Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, Banfalvi A, Krishnaveni MS, Dubourd M, Demaio L, Willis BC, Kim KJ, duBois RM, Crandall ED, Beers MF, Borok Z. Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. PMID: 21169555.
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    27. Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. PMID: 20639441.
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    28. Borok Z, Crandall ED. More life for a "terminal" cell. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1042-4. PMID: 19837848.
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    29. Flodby P, Borok Z, Banfalvi A, Zhou B, Gao D, Minoo P, Ann DK, Morrisey EE, Crandall ED. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. PMID: 19767448.
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    30. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. PMID: 19574531.
      View in: PubMed
    31. Demaio L, Tseng W, Balverde Z, Alvarez JR, Kim KJ, Kelley DG, Senior RM, Crandall ED, Borok Z. Characterization of mouse alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L1051-8. PMID: 19329539.
      View in: PubMed
    32. Patel LN, Wang J, Kim KJ, Borok Z, Crandall ED, Shen WC. Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin. Mol Pharm. 2009 Mar-Apr; 6(2):492-503. PMID: 19228019.
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    33. Zhou B, Francis TA, Yang H, Tseng W, Zhong Q, Frenkel B, Morrisey EE, Ann DK, Minoo P, Crandall ED, Borok Z. GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. PMID: 18768929.
      View in: PubMed
    34. Patel LN, Uchiyama T, Kim KJ, Borok Z, Crandall ED, Shen WC, Lee VH. Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. J Pharm Sci. 2008 Jun; 97(6):2340-9. PMID: 17854063.
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    35. Liebler JM, Lutzko C, Banfalvi A, Senadheera D, Aghamohammadi N, Crandall ED, Borok Z. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L285-92. PMID: 18515407.
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    36. Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall ED, Borok Z. Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. PMID: 18448628.
      View in: PubMed
    37. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. PMID: 18375191.
      View in: PubMed
    38. Uchiyama T, Fujita T, Gukasyan HJ, Kim KJ, Borok Z, Crandall ED, Lee VH. Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes. J Cell Physiol. 2008 Mar; 214(3):645-54. PMID: 17960566.
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    39. Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers. Eur J Pharm Biopharm. 2008 Aug; 69(3):808-16. PMID: 18406118.
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    40. Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z. Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. PMID: 18239190.
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    41. Bates SR, Tao JQ, Yu KJ, Borok Z, Crandall ED, Collins HL, Rothblat GH. Expression and biological activity of ABCA1 in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):283-92. PMID: 17884990.
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    42. Qiao R, Yan W, Clavijo C, Mehrian-Shai R, Zhong Q, Kim KJ, Ann D, Crandall ED, Borok Z. Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):239-46. PMID: 17872496.
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    43. Yacobi NR, Phuleria HC, Demaio L, Liang CH, Peng CA, Sioutas C, Borok Z, Kim KJ, Crandall ED. Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicol In Vitro. 2007 Dec; 21(8):1373-81. PMID: 17555923.
      View in: PubMed
    44. Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s). Pharm Res. 2007 Sep; 24(9):1713-9. PMID: 17443400.
      View in: PubMed
    45. Flodby P, Zhou B, Ann DK, Kim KJ, Minoo P, Crandall ED, Borok Z. Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. PMID: 17339032.
      View in: PubMed
    46. Zhou B, Ann DK, Li X, Kim KJ, Lin H, Minoo P, Crandall ED, Borok Z. Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. PMID: 17108010.
      View in: PubMed
    47. Nguyen HV, Chen JL, Zhong J, Kim KJ, Crandall ED, Borok Z, Chen Y, Ann DK. SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Am J Pathol. 2006 May; 168(5):1452-63. PMID: 16651613; PMCID: PMC1606580.
    48. Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol. 2005 May; 166(5):1321-32. PMID: 15855634; PMCID: PMC1606388.
    49. Bourke S, Mason HS, Borok Z, Kim KJ, Crandall ED, Kemp PJ. Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells. Respir Res. 2005 Apr 27; 6:40. PMID: 15857506; PMCID: PMC1131928.
    50. Chen SP, Zhou B, Willis BC, Sandoval AJ, Liebler JM, Kim KJ, Ann DK, Crandall ED, Borok Z. Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol (1985). 2005 Jan; 98(1):322-8. PMID: 15361518.
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    51. Kim KJ, Borok Z, Ehrhardt C, Willis BC, Lehr CM, Crandall ED. Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers. J Appl Physiol (1985). 2005 Jan; 98(1):138-43. PMID: 15273240.
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    52. Liebler JM, Borok Z, Li X, Zhou B, Sandoval AJ, Kim KJ, Crandall ED. Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2. J Histochem Cytochem. 2004 Jun; 52(6):759-67. PMID: 15150284.
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    53. Kim KJ, Fandy TE, Lee VH, Ann DK, Borok Z, Crandall ED. Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L616-22. PMID: 15169676.
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    54. Qiao R, Zhou B, Harboe-Schmidt E, Kasahara N, Kim KJ, Liebler JM, Crandall ED, Borok Z. Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. PMID: 15144576.
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    55. Kelley MA, Angus D, Chalfin DB, Crandall ED, Ingbar D, Johanson W, Medina J, Sessler CN, Vender JS. The critical care crisis in the United States: a report from the profession. Chest. 2004 Apr; 125(4):1514-7. PMID: 15078767.
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    56. Widera A, Kim KJ, Crandall ED, Shen WC. Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers. Pharm Res. 2003 Aug; 20(8):1231-8. PMID: 12948021.
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    57. Widera A, Beloussow K, Kim KJ, Crandall ED, Shen WC. Phenotype-dependent synthesis of transferrin receptor in rat alveolar epithelial cell monolayers. Cell Tissue Res. 2003 Jun; 312(3):313-8. PMID: 12739130.
      View in: PubMed
    58. Willis BC, Kim KJ, Li X, Liebler J, Crandall ED, Borok Z. Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1192-200. PMID: 12730080.
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    59. Qiao R, Zhou B, Liebler JM, Li X, Crandall ED, Borok Z. Identification of three genes of known function expressed by alveolar epithelial type I cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. PMID: 12600825.
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    60. Kim KJ, Matsukawa Y, Yamahara H, Kalra VK, Lee VH, Crandall ED. Absorption of intact albumin across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Mar; 284(3):L458-65. PMID: 12573985.
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    61. Crandall ED, Effros RM. Historical perspectives on lung edema clearance. J Appl Physiol (1985). 2002 Oct; 93(4):1527-32. PMID: 12235055.
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    62. Joseph D, Tirmizi O, Zhang XL, Crandall ED, Lubman RL. Polarity of alveolar epithelial cell acid-base permeability. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L675-83. PMID: 11880292.
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    63. Mairbäurl H, Mayer K, Kim KJ, Borok Z, Bärtsch P, Crandall ED. Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L659-65. PMID: 11880290.
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    64. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim KJ, Crandall ED. Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. PMID: 11880284.
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    65. Borok Z, Harboe-Schmidt JE, Brody SL, You Y, Zhou B, Li X, Cannon PM, Kim KJ, Crandall ED, Kasahara N. Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells. J Virol. 2001 Dec; 75(23):11747-54. PMID: 11689655; PMCID: PMC114760.
    66. Kemp PJ, Kim KJ, Borok Z, Crandall ED. Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels. J Physiol. 2001 Nov 01; 536(Pt 3):693-701. PMID: 11691865; PMCID: PMC2278905.
    67. Crandall ED, Matthay MA. Alveolar epithelial transport. Basic science to clinical medicine. Am J Respir Crit Care Med. 2001 Mar; 163(4):1021-9. PMID: 11282783.
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    68. Kim KJ, Borok Z, Crandall ED. A useful in vitro model for transport studies of alveolar epithelial barrier. Pharm Res. 2001 Mar; 18(3):253-5. PMID: 11442260.
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    69. Borok Z, Li X, Fernandes VF, Zhou B, Ann DK, Crandall ED. Differential regulation of rat aquaporin-5 promoter/enhancer activities in lung and salivary epithelial cells. J Biol Chem. 2000 Aug 25; 275(34):26507-14. PMID: 10849430.
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    70. Matsukawa Y, Yamahara H, Yamashita F, Lee VH, Crandall ED, Kim KJ. Rates of protein transport across rat alveolar epithelial cell monolayers. J Drug Target. 2000; 7(5):335-42. PMID: 10721795.
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    71. Kemp PJ, Borok Z, Kim KJ, Lubman RL, Danto SI, Crandall ED. Epidermal growth factor regulation in adult rat alveolar type II cells of amiloride-sensitive cation channels. Am J Physiol. 1999 12; 277(6):C1058-65. PMID: 10600757.
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    72. Borok Z, Danto SI, Lubman RL, Cao Y, Williams MC, Crandall ED. Modulation of t1alpha expression with alveolar epithelial cell phenotype in vitro. Am J Physiol. 1998 07; 275(1):L155-64. PMID: 9688947.
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    73. Danto SI, Borok Z, Zhang XL, Lopez MZ, Patel P, Crandall ED, Lubman RL. Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells. Am J Physiol. 1998 07; 275(1):C82-92. PMID: 9688838.
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    74. Borok Z, Lubman RL, Danto SI, Zhang XL, Zabski SM, King LS, Lee DM, Agre P, Crandall ED. Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5. Am J Respir Cell Mol Biol. 1998 Apr; 18(4):554-61. PMID: 9533944.
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    75. Matsukawa Y, Lee VH, Crandall ED, Kim KJ. Size-dependent dextran transport across rat alveolar epithelial cell monolayers. J Pharm Sci. 1997 Mar; 86(3):305-9. PMID: 9050797.
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    76. Zhang M, Kim KJ, Iyer D, Lin Y, Belisle J, McEnery K, Crandall ED, Barnes PF. Effects of Mycobacterium tuberculosis on the bioelectric properties of the alveolar epithelium. Infect Immun. 1997 Feb; 65(2):692-8. PMID: 9009332.
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    77. Matsukawa Y, Yamahara H, Lee VH, Crandall ED, Kim KJ. Horseradish peroxidase transport across rat alveolar epithelial cell monolayers. Pharm Res. 1996 Sep; 13(9):1331-5. PMID: 9026792.
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    78. Borok Z, Hami A, Danto SI, Lubman RL, Kim KJ, Crandall ED. Effects of EGF on alveolar epithelial junctional permeability and active sodium transport. Am J Physiol. 1996 Apr; 270(4 Pt 1):L559-65. PMID: 8928815.
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    79. Kim KJ, Crandall ED. Models for investigation of peptide and protein transport across cultured mammalian respiratory epithelial barriers. Pharm Biotechnol. 1996; 8:325-46. PMID: 8791817.
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    80. Danto SI, Shannon JM, Borok Z, Zabski SM, Crandall ED. Reversible transdifferentiation of alveolar epithelial cells. Am J Respir Cell Mol Biol. 1995 May; 12(5):497-502. PMID: 7742013.
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    81. Lubman RL, Chao DC, Crandall ED. Basolateral localization of Na(+)-HCO3- cotransporter activity in alveolar epithelial cells. Respir Physiol. 1995 Apr; 100(1):15-24. PMID: 7604180.
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    82. Lubman RL, Danto SI, Chao DC, Fricks CE, Crandall ED. Cl(-)-HCO3- exchanger isoform AE2 is restricted to the basolateral surface of alveolar epithelial cell monolayers. Am J Respir Cell Mol Biol. 1995 Feb; 12(2):211-9. PMID: 7865219.
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    83. Borok Z, Hami A, Danto SI, Zabski SM, Crandall ED. Rat serum inhibits progression of alveolar epithelial cells toward the type I cell phenotype in vitro. Am J Respir Cell Mol Biol. 1995 Jan; 12(1):50-5. PMID: 7811470.
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    84. Danto SI, Zabski SM, Crandall ED. Late appearance of a type I alveolar epithelial cell marker during fetal rat lung development. Histochemistry. 1994 Oct; 102(4):297-304. PMID: 7531192.
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    85. Lubman RL, Crandall ED. Polarized distribution of Na(+)-H+ antiport activity in rat alveolar epithelial cells. Am J Physiol. 1994 Feb; 266(2 Pt 1):L138-47. PMID: 8141309.
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    86. Borok Z, Danto SI, Zabski SM, Crandall ED. Defined medium for primary culture de novo of adult rat alveolar epithelial cells. In Vitro Cell Dev Biol Anim. 1994 Feb; 30A(2):99-104. PMID: 8012662.
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    87. McLaughlin GE, Kim KJ, Berg MM, Agoris P, Lubman RL, Crandall ED. Measurement of solute fluxes in isolated rat lungs. Respir Physiol. 1993 Mar; 91(2-3):321-34. PMID: 8469854.
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    88. Russo RM, Lubman RL, Crandall ED. Evidence for amiloride-sensitive sodium channels in alveolar epithelial cells. Am J Physiol. 1992 Apr; 262(4 Pt 1):L405-11. PMID: 1314501.
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    89. Danto SI, Zabski SM, Crandall ED. Reactivity of alveolar epithelial cells in primary culture with type I cell monoclonal antibodies. Am J Respir Cell Mol Biol. 1992 Mar; 6(3):296-306. PMID: 1540393.
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    90. Lubman RL, Crandall ED. Regulation of intracellular pH in alveolar epithelial cells. Am J Physiol. 1992 Jan; 262(1 Pt 1):L1-14. PMID: 1310224.
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    91. Kim KJ, Cheek JM, Crandall ED. Contribution of active Na+ and Cl- fluxes to net ion transport by alveolar epithelium. Respir Physiol. 1991 Aug; 85(2):245-56. PMID: 1947462.
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    92. Lubman RL, Crandall ED. Na(+)-HCO3- symport modulates intracellular pH in alveolar epithelial cells. Am J Physiol. 1991 Jun; 260(6 Pt 1):L555-61. PMID: 2058696.
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    93. Cheek JM, Kim KJ, Crandall ED. NO2 decreases paracellular resistance to ion and solute flow in alveolar epithelial monolayers. Exp Lung Res. 1990 Nov-Dec; 16(6):561-75. PMID: 2081503.
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    94. Staub NC, Hyde RW, Crandall E. NHLBI workshop summary. Workshop on techniques to evaluate lung alveolar-microvascular injury. Am Rev Respir Dis. 1990 Apr; 141(4 Pt 1):1071-7. PMID: 2183655.
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    95. Lubman RL, Danto SI, Crandall ED. Evidence for active H+ secretion by rat alveolar epithelial cells. Am J Physiol. 1989 Dec; 257(6 Pt 1):L438-45. PMID: 2610271.
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    96. Cheek JM, Evans MJ, Crandall ED. Type I cell-like morphology in tight alveolar epithelial monolayers. Exp Cell Res. 1989 Oct; 184(2):375-87. PMID: 2806398.
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    97. Crandall ED, Kim KJ. Protein traffic across lung epithelia. Am J Respir Cell Mol Biol. 1989 Oct; 1(4):255. PMID: 2624763.
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    98. Berg MM, Kim KJ, Lubman RL, Crandall ED. Hydrophilic solute transport across rat alveolar epithelium. J Appl Physiol (1985). 1989 May; 66(5):2320-7. PMID: 2745296.
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    99. Cheek JM, Kim KJ, Crandall ED. Tight monolayers of rat alveolar epithelial cells: bioelectric properties and active sodium transport. Am J Physiol. 1989 Mar; 256(3 Pt 1):C688-93. PMID: 2923201.
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    100. Kim KJ, Crandall ED. Sodium-dependent lysine flux across bullfrog alveolar epithelium. J Appl Physiol (1985). 1988 Oct; 65(4):1655-61. PMID: 3141361.
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    101. Nord EP, Brown SE, Crandall ED. Cl-/HCO3- exchange modulates intracellular pH in rat type II alveolar epithelial cells. J Biol Chem. 1988 Apr 25; 263(12):5599-606. PMID: 3356700.
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    102. Cheek JM, Postlethwait EM, Crandall ED. Effects of culture conditions on susceptibility of alveolar epithelial cell monolayers to NO2. Toxicol Lett. 1988 Mar; 40(3):247-55. PMID: 3354009.
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    103. Crandall ED, Cheek JM, Shaw ME, Postlethwait EM. Effects of nitrogen dioxide on alveolar epithelial barrier properties. Res Rep Health Eff Inst. 1987 Oct; (13):3-19. PMID: 3269254.
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    104. Goodman BE, Kim KJ, Crandall ED. Evidence for active sodium transport across alveolar epithelium of isolated rat lung. J Appl Physiol (1985). 1987 Jun; 62(6):2460-6. PMID: 3610939.
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    105. Nord EP, Brown SE, Crandall ED. Characterization of Na+-H+ antiport in type II alveolar epithelial cells. Am J Physiol. 1987 May; 252(5 Pt 1):C490-8. PMID: 3034070.
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    106. Cheek JM, Postlethwait EM, Shaw ME, Crandall ED. Effects of exposure to NO2 on dome formation in alveolar epithelial cell monolayers. Environ Res. 1987 Feb; 42(1):1-11. PMID: 3542522.
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    107. Heming TA, Geers C, Gros G, Bidani A, Crandall ED. Effects of dextran-bound inhibitors on carbonic anhydrase activity in isolated rat lungs. J Appl Physiol (1985). 1986 Nov; 61(5):1849-56. PMID: 2430932.
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    108. Crandall ED, Heming TA, Palombo RL, Goodman BE. Effects of terbutaline on sodium transport in isolated perfused rat lung. J Appl Physiol (1985). 1986 Jan; 60(1):289-94. PMID: 3944038.
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    109. Brown SE, Kim KJ, Goodman BE, Wells JR, Crandall ED. Sodium-amino acid cotransport by type II alveolar epithelial cells. J Appl Physiol (1985). 1985 Nov; 59(5):1616-22. PMID: 4066594.
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    110. Kim KJ, LeBon TR, Shinbane JS, Crandall ED. Asymmetric [14C]albumin transport across bullfrog alveolar epithelium. J Appl Physiol (1985). 1985 Oct; 59(4):1290-7. PMID: 3877046.
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    111. Goodman BE, Brown SE, Crandall ED. Regulation of transport across pulmonary alveolar epithelial cell monolayers. J Appl Physiol Respir Environ Exerc Physiol. 1984 Sep; 57(3):703-10. PMID: 6149212.
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    112. Bidani A, Crandall ED, DuBose TD. Analysis of the determinants of renal cortical PCO2. Am J Physiol. 1984 Sep; 247(3 Pt 2):F466-74. PMID: 6433722.
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    113. Schaeffer JD, Kim KJ, Crandall ED. Effects of cell swelling on fluid flow across alveolar epithelium. J Appl Physiol Respir Environ Exerc Physiol. 1984 Jan; 56(1):72-7. PMID: 6607246.
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    114. Brown SE, Goodman BE, Crandall ED. Type II alveolar epithelial cells in suspension: separation by density and velocity. Lung. 1984; 162(5):271-80. PMID: 6513594.
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    115. Crandall ED, Staub NC, Goldberg HS, Effros RM. Recent developments in pulmonary edema. Ann Intern Med. 1983 Dec; 99(6):808-22. PMID: 6360001.
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    116. Goodman BE, Fleischer RS, Crandall ED. Evidence for active Na+ transport by cultured monolayers of pulmonary alveolar epithelial cells. Am J Physiol. 1983 Jul; 245(1):C78-83. PMID: 6869523.
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    117. Crandall ED. Water and nonelectrolyte transport across alveolar epithelium. Am Rev Respir Dis. 1983 May; 127(5 Pt 2):S16-24. PMID: 6221680.
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    118. Kim KJ, Crandall ED. Heteropore populations of bullfrog alveolar epithelium. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):140-6. PMID: 6600738.
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    119. Goodman BE, Crandall ED. Dome formation in primary cultured monolayers of alveolar epithelial cells. Am J Physiol. 1982 Jul; 243(1):C96-100. PMID: 7046469.
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    120. Kim KJ, Crandall ED. Effects of lung inflation on alveolar epithelial solute and water transport properties. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun; 52(6):1498-505. PMID: 6980871.
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    121. Kim KJ, Crandall ED. Effects of exposure to acid on alveolar epithelial water and solute transport. J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr; 52(4):902-9. PMID: 6979533.
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    122. Crandall ED, Winter HI, Schaeffer JD, Bidani A. Effects of salicylate on HCO-3/Cl- exchange across the human erythrocyte membrane. J Membr Biol. 1982; 65(1-2):139-45. PMID: 7057459.
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    123. Crandall ED, Mathew SJ, Fleischer RS, Winter HI, Bidani A. Effects of inhibition of RBC HCO3-/Cl- exchange on CO2 excretion and downstream pH disequilibrium in isolated rat lungs. J Clin Invest. 1981 Oct; 68(4):853-62. PMID: 6793631.
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    124. Crandall ED, Kim KJ. Transport of water and solutes across bullfrog alveolar epithelium. J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun; 50(6):1263-71. PMID: 6790496.
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    125. Crandall ED, Bidani A. Effects of red blood cell HCO3(-)/Cl- exchange kinetics on lung CO2 transfer: theory. J Appl Physiol Respir Environ Exerc Physiol. 1981 Feb; 50(2):265-71. PMID: 6782059.
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    126. Obaid AL, Leininger TF, Crandall ED. Exchange of HCO3- for monovalent anions across the human erythrocyte membrane. J Membr Biol. 1980; 52(2):173-9. PMID: 6767850.
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    127. Obaid AL, Crandall ED. HCO3-/Cl- exchange across the human erythrocyte membrane: effects of pH and temperature. J Membr Biol. 1979 Oct 05; 50(1):23-41. PMID: 41100.
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    128. Kim KJ, Critz AM, Crandall ED. Transport of water and solutes across sheep visceral pleura. Am Rev Respir Dis. 1979 Oct; 120(4):883-92. PMID: 507515.
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    129. Obaid AL, Critz AM, Crandall ED. Kinetics of bicarbonate/chloride exchange in dogfish erythrocytes. Am J Physiol. 1979 Sep; 237(3):R132-8. PMID: 112874.
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    130. Crandall ED, Critz AM, Osher AS, Keljo DJ, Forster RE. Influence of pH on elastic deformability of the human erythrocyte membrane. Am J Physiol. 1978 Nov; 235(5):C269-78. PMID: 31792.
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    131. Bidani A, Crandall ED. Analysis of PCO2 differences during rebreathing due to slow pH equilibration in blood. J Appl Physiol Respir Environ Exerc Physiol. 1978 Nov; 45(5):666-73. PMID: 32159.
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    132. Bidani A, Flumerfelt RW, Crandall ED. Analysis of the effects of pulsatile capillary blood flow and volume on gas exchange. Respir Physiol. 1978 Oct; 35(1):27-42. PMID: 734248.
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    133. Crandall ED, Obaid AL, Forster RE. Bicarbonate-chloride exchange in erythrocyte suspensions. Stopped-flow pH electrode measurements. Biophys J. 1978 Oct; 24(1):35-47. PMID: 30493.
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    134. Crandall ED, O'Brasky JE. Direct evidence of participation of rat lung carbonic anhydrase in CO2 reactions. J Clin Invest. 1978 Sep; 62(3):618-22. PMID: 29055.
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    135. Bidani A, Crandall ED, Forster RE. Analysis of postcapillary pH changes in blood in vivo after gas exchange. J Appl Physiol Respir Environ Exerc Physiol. 1978 May; 44(5):770-81. PMID: 25860.
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    136. Chow EI, Crandall ED, Forster RE. Kinetics of bicarbonate-chloride exchange across the human red blood cell membrane. J Gen Physiol. 1976 Dec; 68(6):633-52. PMID: 993774.
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    137. Forster RE, Crandall ED. Pulmonarygas exchange. Annu Rev Physiol. 1976; 38:69-93. PMID: 769659.
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    138. Crandall ED, Klocke RA, Forster RE. Hydroxyl ion movements across the human erythrocyte membrane. Measurement of rapid pH changes in red cell suspensions. J Gen Physiol. 1971 Jun; 57(6):664-83. PMID: 5576765.
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