Edward David Crandall, PhD, MD

Title(s)Professor of Medicine
Address2020 Zonal Ave.
Off Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)Hastings Foundation Professorship in Medicine


    Collapse Biography 
    Collapse Awards and Honors
    2005  - PresBest Doctors of America
    National Institutes of Health1987  - 1997MERIT Award
    National Institutes of Health1975  - 1980Research Career Development Award
    University of PennsylvaniaChair of Department of Medicine Scholarship
    U.S. Public Health ServiceSpecial Fellowship
    Royal E. Cabell Fellowship
    National Science FoundationGraduate Fellowship
    Union Carbide Fellowship
    Walter P. Murphy Fellowship
    New York StateRegents Scholarship

    Collapse Overview 
    Collapse Overview
    Dr. Crandall's research has been focused on the following topics: markers of alveolar epithelial cell development and differentiation, regulation of pulmonary epithelial cell differentiation, acute and chronic lung injury and the factors that influence recovery, transport properties of pulmonary alveolar epithelium, and biology of nanoparticle interactions with alveolar epithelial cells.

    Dr. Crandall received his B.Ch.E. from Cooper Union, his M.S. and Ph.D. in chemical engineering from Northwestern University, and his M.D. from the University of Pennsylvania. His training in internal medicine and pulmonary/critical care medicine was undertaken at the Hospital of the University of Pennsylvania.

    Collapse Research 
    Collapse Research Activities and Funding
    MAPGen Knowledge Base (MAPGenKB) and Coordination Center
    NIH U01HL108634Aug 25, 2011 - May 31, 2018
    Role: Co-Principal Investigator
    Interactions of engineered nanomaterials with lung alveolar epithelium
    NIH RC2ES018782Sep 25, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Nanoparticle properties and alveolar epithelial barrier/transport functions
    NIH R01ES017034Jun 15, 2009 - Mar 31, 2015
    Role: Principal Investigator
    Absorption mechanisms for peptide/protein drugs via lung
    NIH R01HL064365Sep 30, 1999 - Jul 31, 2010
    Role: Principal Investigator
    AT1 vs AT2 cells: differential roles in alveolar function and biology
    NIH R01HL038621Jan 15, 1991 - Jun 30, 2012
    Role: Principal Investigator
    GATA-6: Key Regulator of AEC Transdifferentiation
    NIH R01HL038578Sep 1, 1986 - Nov 30, 2008
    Role: Co-Principal Investigator
    LUNG EPITHELIAL TRANSPORT PROPERTIES AND ALVEOLAR EDEMA
    NIH R37HL038578Sep 1, 1986 - Aug 31, 1997
    Role: Principal Investigator
    DETERMINANTS OF LUNG AND TISSUE CO2 EXCHANGE AND TRANSPO
    NIH R01HL025669Aug 1, 1980 - Aug 31, 1986
    Role: Principal Investigator
    LUNG EPITHELIAL TRANSPORT PROPERTIES AND ALVEOLAR EDEMA
    NIH R01HL026223Aug 1, 1980 - Aug 31, 1986
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Characteristics of Passive Solute Transport across Primary Rat Alveolar Epithelial Cell Monolayers. Membranes (Basel). 2021 Apr 30; 11(5). Kim YH, Kim KJ, D'Argenio DZ, Crandall ED. PMID: 33946241.
      View in: PubMed   Mentions:
    2. Biokinetic modeling of nanoparticle interactions with lung alveolar epithelial cells: uptake, intracellular processing, and egress. Am J Physiol Regul Integr Comp Physiol. 2021 01 01; 320(1):R36-R43. Chen W, D'Argenio DZ, Sipos A, Kim KJ, Crandall ED. PMID: 33085912.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020 03 09; 52(5):617-630.e6. Vila Ellis L, Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J. PMID: 32059772.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    4. Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells. Int J Mol Sci. 2019 Oct 23; 20(21). Sipos A, Kim KJ, Sioutas C, Crandall ED. PMID: 31652767.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20545-20555. Little DR, Gerner-Mauro KN, Flodby P, Crandall ED, Borok Z, Akiyama H, Kimura S, Ostrin EJ, Chen J. PMID: 31548395.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    6. CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. Luo J, Chimge NO, Zhou B, Flodby P, Castaldi A, Firth AL, Liu Y, Wang H, Yang C, Marconett CN, Crandall ED, Offringa IA, Frenkel B, Borok Z. PMID: 30325015.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis. . 2018 08 01; 315(2):L286-L300. Sipos A, Kim KJ, Chow RH, Flodby P, Borok Z, Crandall ED. PMID: 29722567.
      View in: PubMed   Mentions:
    8. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 03 01; 128(3):970-984. Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z. PMID: 29400695.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    9. Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse. . 2017 Dec 01; 313(6):L1016-L1029. Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP. PMID: 28839100.
      View in: PubMed   Mentions:
    10. Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2. Pharm Res. 2017 Dec; 34(12):2488-2497. Gukasyan HJ, Uchiyama T, Kim KJ, Ehrhardt C, Wu SK, Borok Z, Crandall ED, Lee VHL. PMID: 28831683.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017 Aug 01; 127(8):3136-3151. Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR. PMID: 28737509.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    12. Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation. Sci Rep. 2017 06 14; 7(1):3473. Flodby P, Li C, Liu Y, Wang H, Rieger ME, Minoo P, Crandall ED, Ann DK, Borok Z, Zhou B. PMID: 28615712.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    13. Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes. Am J Respir Cell Mol Biol. 2017 03; 56(3):310-321. Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z. PMID: 27749084.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. Region-specific role for Pten in maintenance of epithelial phenotype and integrity. . 2017 01 01; 312(1):L131-L142. Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall ED, Minoo P, Borok Z. PMID: 27864284.
      View in: PubMed   Mentions:
    15. IL-1R1-MyD88 axis elicits papain-induced lung inflammation. Eur J Immunol. 2016 11; 46(11):2531-2541. Agoro R, Piotet-Morin J, Palomo J, Michaudel C, Vigne S, Maillet I, Chenuet P, Guillou N, Le Bérichel J, Kisielow M, Flodby P, Borok Z, Crandall ED, Le Bert M, Quesniaux V, Muller M, Di Padova F, Ryffel B, Gabay C, Couturier-Maillard A. PMID: 27569535.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 09; 55(3):395-406. Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED. PMID: 27064541.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    17. p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z. PMID: 26833564.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    18. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2263-8. Catalán MA, Kondo Y, Peña-Munzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE. PMID: 25646474.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    19. Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. . 2014 Oct 01; 307(7):L524-36. Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z. PMID: 25106430.
      View in: PubMed   Mentions:
    20. Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. PMID: 24588076.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    21. DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, Sun F, Waterman M, Chen JJ, Chaudhary PM, Loscalzo J, Crandall E, Zhou XJ. PMID: 24895436.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    22. Polystyrene nanoparticle exposure induces ion-selective pores in lipid bilayers. Biochim Biophys Acta. 2013 Sep; 1828(9):2215-22. Negoda A, Kim KJ, Crandall ED, Worden RM. PMID: 23747366.
      View in: PubMed   Mentions: 2     Fields:    
    23. Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium. Environ Health Perspect. 2013 Jun; 121(6):683-90. Xia T, Hamilton RF, Bonner JC, Crandall ED, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A. PMID: 23649538.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    24. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 23454523.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Troglitazone attenuates TGF-ß1-induced EMT in alveolar epithelial cells via a PPAR?-independent mechanism. PLoS One. 2012; 7(6):e38827. Zhou B, Buckley ST, Patel V, Liu Y, Luo J, Krishnaveni MS, Ivan M, DeMaio L, Kim KJ, Ehrhardt C, Crandall ED, Borok Z. PMID: 22745681.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem. 2012 Mar 02; 287(10):7026-38. Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z. PMID: 22241478.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    27. Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. DeMaio L, Buckley ST, Krishnaveni MS, Flodby P, Dubourd M, Banfalvi A, Xing Y, Ehrhardt C, Minoo P, Zhou B, Crandall ED, Borok Z. PMID: 21984393.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    28. Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57. Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 22131830.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles. Air Qual Atmos Health. 2011 Mar 01; 4(1):65-78. Yacobi NR, Fazllolahi F, Kim YH, Sipos A, Borok Z, Kim KJ, Crandall ED. PMID: 25568662.
      View in: PubMed   Mentions:
    30. Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 21310266.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    31. Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, Banfalvi A, Krishnaveni MS, Dubourd M, Demaio L, Willis BC, Kim KJ, duBois RM, Crandall ED, Beers MF, Borok Z. PMID: 21169555.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    32. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 20639441.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    33. More life for a "terminal" cell. . 2009 Dec; 297(6):L1042-4. Borok Z, Crandall ED. PMID: 19837848.
      View in: PubMed   Mentions:
    34. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. Flodby P, Borok Z, Banfalvi A, Zhou B, Gao D, Minoo P, Ann DK, Morrisey EE, Crandall ED. PMID: 19767448.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    35. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 19574531.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    36. Characterization of mouse alveolar epithelial cell monolayers. . 2009 Jun; 296(6):L1051-8. Demaio L, Tseng W, Balverde Z, Alvarez JR, Kim KJ, Kelley DG, Senior RM, Crandall ED, Borok Z. PMID: 19329539.
      View in: PubMed   Mentions:
    37. Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin. Mol Pharm. 2009 Mar-Apr; 6(2):492-503. Patel LN, Wang J, Kim KJ, Borok Z, Crandall ED, Shen WC. PMID: 19228019.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. . 2008 Nov; 295(5):C1141-50. Zhou B, Francis TA, Yang H, Tseng W, Zhong Q, Frenkel B, Morrisey EE, Ann DK, Minoo P, Crandall ED, Borok Z. PMID: 18768929.
      View in: PubMed   Mentions:
    39. Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. J Pharm Sci. 2008 Jun; 97(6):2340-9. Patel LN, Uchiyama T, Kim KJ, Borok Z, Crandall ED, Shen WC, Lee VH. PMID: 17854063.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    40. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. . 2008 Aug; 295(2):L285-92. Liebler JM, Lutzko C, Banfalvi A, Senadheera D, Aghamohammadi N, Crandall ED, Borok Z. PMID: 18515407.
      View in: PubMed   Mentions:
    41. Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. . 2008 Jul; 295(1):C111-20. Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall ED, Borok Z. PMID: 18448628.
      View in: PubMed   Mentions:
    42. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 18375191.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    43. Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes. J Cell Physiol. 2008 Mar; 214(3):645-54. Uchiyama T, Fujita T, Gukasyan HJ, Kim KJ, Borok Z, Crandall ED, Lee VH. PMID: 17960566.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    44. Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers. Eur J Pharm Biopharm. 2008 Aug; 69(3):808-16. Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. PMID: 18406118.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    45. Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z. PMID: 18239190.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    46. Expression and biological activity of ABCA1 in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):283-92. Bates SR, Tao JQ, Yu KJ, Borok Z, Crandall ED, Collins HL, Rothblat GH. PMID: 17884990.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    47. Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):239-46. Qiao R, Yan W, Clavijo C, Mehrian-Shai R, Zhong Q, Kim KJ, Ann D, Crandall ED, Borok Z. PMID: 17872496.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    48. Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicol In Vitro. 2007 Dec; 21(8):1373-81. Yacobi NR, Phuleria HC, Demaio L, Liang CH, Peng CA, Sioutas C, Borok Z, Kim KJ, Crandall ED. PMID: 17555923.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    49. Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s). Pharm Res. 2007 Sep; 24(9):1713-9. Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. PMID: 17443400.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    50. Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. Flodby P, Zhou B, Ann DK, Kim KJ, Minoo P, Crandall ED, Borok Z. PMID: 17339032.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    51. Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. . 2007 Apr; 292(4):C1280-90. Zhou B, Ann DK, Li X, Kim KJ, Lin H, Minoo P, Crandall ED, Borok Z. PMID: 17108010.
      View in: PubMed   Mentions:
    52. SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Am J Pathol. 2006 May; 168(5):1452-63. Nguyen HV, Chen JL, Zhong J, Kim KJ, Crandall ED, Borok Z, Chen Y, Ann DK. PMID: 16651613.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    53. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol. 2005 May; 166(5):1321-32. Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. PMID: 15855634.
      View in: PubMed   Mentions: 367     Fields:    Translation:HumansAnimalsCells
    54. Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells. Respir Res. 2005 Apr 27; 6:40. Bourke S, Mason HS, Borok Z, Kim KJ, Crandall ED, Kemp PJ. PMID: 15857506.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    55. Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol (1985). 2005 Jan; 98(1):322-8. Chen SP, Zhou B, Willis BC, Sandoval AJ, Liebler JM, Kim KJ, Ann DK, Crandall ED, Borok Z. PMID: 15361518.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    56. Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers. J Appl Physiol (1985). 2005 Jan; 98(1):138-43. Kim KJ, Borok Z, Ehrhardt C, Willis BC, Lehr CM, Crandall ED. PMID: 15273240.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    57. Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2. J Histochem Cytochem. 2004 Jun; 52(6):759-67. Liebler JM, Borok Z, Li X, Zhou B, Sandoval AJ, Kim KJ, Crandall ED. PMID: 15150284.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    58. Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers. . 2004 Sep; 287(3):L616-22. Kim KJ, Fandy TE, Lee VH, Ann DK, Borok Z, Crandall ED. PMID: 15169676.
      View in: PubMed   Mentions:
    59. Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. Qiao R, Zhou B, Harboe-Schmidt E, Kasahara N, Kim KJ, Liebler JM, Crandall ED, Borok Z. PMID: 15144576.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    60. The critical care crisis in the United States: a report from the profession. Chest. 2004 Apr; 125(4):1514-7. Kelley MA, Angus D, Chalfin DB, Crandall ED, Ingbar D, Johanson W, Medina J, Sessler CN, Vender JS. PMID: 15078767.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    61. Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers. Pharm Res. 2003 Aug; 20(8):1231-8. Widera A, Kim KJ, Crandall ED, Shen WC. PMID: 12948021.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    62. Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers. . 2003 Dec; 285(6):L1192-200. Willis BC, Kim KJ, Li X, Liebler J, Crandall ED, Borok Z. PMID: 12730080.
      View in: PubMed   Mentions:
    63. Identification of three genes of known function expressed by alveolar epithelial type I cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. Qiao R, Zhou B, Liebler JM, Li X, Crandall ED, Borok Z. PMID: 12600825.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    64. Absorption of intact albumin across rat alveolar epithelial cell monolayers. . 2003 Mar; 284(3):L458-65. Kim KJ, Matsukawa Y, Yamahara H, Kalra VK, Lee VH, Crandall ED. PMID: 12573985.
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    65. Historical perspectives on lung edema clearance. J Appl Physiol (1985). 2002 Oct; 93(4):1527-32. Crandall ED, Effros RM. PMID: 12235055.
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    67. Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. . 2002 Apr; 282(4):L659-65. Mairbäurl H, Mayer K, Kim KJ, Borok Z, Bärtsch P, Crandall ED. PMID: 11880290.
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    68. Na transport proteins are expressed by rat alveolar epithelial type I cells. . 2002 Apr; 282(4):L599-608. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim KJ, Crandall ED. PMID: 11880284.
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