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Engineering B cells to Express Fully Customizable Antibodies with Enhanced Fc Functions. Res Sq. 2025 Sep 09.
Huang C, Mathur A, Chang CH, Huang X, Chen HY, Davis ZB, O'Dell K, Shuman EA, Kung RW, Rogers GL, Cannon PM. PMID: 40964038; PMCID: PMC12440107.
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PubMed Mentions:
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Engineering B cells to Express Fully Customizable Antibodies with Enhanced Fc Functions. bioRxiv. 2025 Jul 27.
Huang C, Mathur A, Chang CH, Huang X, Chen HY, Davis ZB, O'Dell K, Shuman EA, Kung RW, Rogers GL, Cannon PM. PMID: 40777290; PMCID: PMC12330693.
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PubMed Mentions:
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International Call for a 10-Year Moratorium on Heritable Human Genome Editing: A multi-stakeholder initiative to ensure safe and responsible use of genetic technologies May 2025. Cytotherapy. 2025 Aug; 27(8):885-887.
Barrett D, Cannon P, Forte M, Hunt T, Jang Q, Smith D. PMID: 40493001.
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PubMed Mentions: Fields:
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Correction: Limited potential of AAV-mediated gene therapy in transducing human mesenchymal stem cells for bone repair applications. Gene Ther. 2024 Sep; 31(9-10):527.
Bougioukli S, Chateau M, Morales H, Vakhshori V, Sugiyama O, Oakes D, Longjohn D, Cannon P, Lieberman JR. PMID: 39090205.
View in:
PubMed Mentions:
1 Fields:
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Reprogramming human B cells with custom heavy-chain antibodies. Nat Biomed Eng. 2024 Dec; 8(12):1700-1714.
Rogers GL, Huang C, Mathur A, Huang X, Chen HY, Stanten K, Morales H, Chang CH, Kezirian EJ, Cannon PM. PMID: 39039240.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Comparison of SARS-CoV-2 entry inhibitors based on ACE2 receptor or engineered Spike-binding peptides. J Virol. 2023 08 31; 97(8):e0068423.
Llewellyn GN, Chen HY, Rogers GL, Huang X, Sell PJ, Henley JE, Cannon PM. PMID: 37555663; PMCID: PMC10506483.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Reprogramming human B cells with custom heavy chain antibodies. Res Sq. 2023 Jul 17.
Rogers GL, Huang C, Mathur A, Huang X, Chen HY, Stanten K, Morales H, Chang CH, Kezirian EJ, Cannon PM. PMID: 37503066; PMCID: PMC10371167.
View in:
PubMed Mentions:
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Reprogramming human B cells with custom heavy chain antibodies. bioRxiv. 2023 Jun 30.
Rogers GL, Huang C, Mathur A, Huang X, Chen HY, Stanten K, Morales H, Chang CH, Kezirian EJ, Cannon PM. PMID: 37425794; PMCID: PMC10327003.
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PubMed Mentions:
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SARS-CoV-2 Enters Human Leydig Cells and Affects Testosterone Production In Vitro. Cells. 2023 04 20; 12(8).
Li L, Sottas CM, Chen HY, Li Y, Cui H, Villano JS, Mankowski JL, Cannon PM, Papadopoulos V. PMID: 37190107; PMCID: PMC10136776.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects. Nat Commun. 2022 12 05; 13(1):7496.
Krohn L, Heilbron K, Blauwendraat C, Reynolds RH, Yu E, Senkevich K, Rudakou U, Estiar MA, Gustavsson EK, Brolin K, Ruskey JA, Freeman K, Asayesh F, Chia R, Arnulf I, Hu MTM, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Högl B, Stefani A, Ibrahim A, Šonka K, Kemlink D, Oertel W, Janzen A, Plazzi G, Biscarini F, Antelmi E, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Döring F, Cochen De Cock V, Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, 23andMe Research Team, Scholz SW, Ryten M, Bandres-Ciga S, Noyce A, Cannon P, Pihlstrøm L, Nalls MA, Singleton AB, Rouleau GA, Postuma RB, Gan-Or Z. PMID: 36470867; PMCID: PMC9722930.
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PubMed Mentions:
34 Fields:
Translation:
Humans
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Hospital re-admission after critical care survival: a systematic review and meta-analysis. Anaesthesia. 2022 04; 77(4):475-485.
McPeake J, Bateson M, Christie F, Robinson C, Cannon P, Mikkelsen M, Iwashyna TJ, Leyland AH, Shaw M, Quasim T. PMID: 34967011.
View in:
PubMed Mentions:
19 Fields:
Translation:
Humans
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Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021. Nat Med. 2021 12; 27(12):2085-2098.
Deeks SG, Archin N, Cannon P, Collins S, Jones RB, de Jong MAWP, Lambotte O, Lamplough R, Ndung'u T, Sugarman J, Tiemessen CT, Vandekerckhove L, Lewin SR, International AIDS Society (IAS) Global Scientific Strategy working group. PMID: 34848888.
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PubMed Mentions:
171 Fields:
Translation:
Humans
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Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning. Mol Neurobiol. 2022 Feb; 59(2):1002-1017.
Lundquist AJ, Llewellyn GN, Kishi SH, Jakowec NA, Cannon PM, Petzinger GM, Jakowec MW. PMID: 34822124.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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The genome-editing decade. Mol Ther. 2021 11 03; 29(11):3093-3094.
Cannon PM, Kiem HP. PMID: 34699779; PMCID: PMC8571477.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Genome edited B cells: a new frontier in immune cell therapies. Mol Ther. 2021 11 03; 29(11):3192-3204.
Rogers GL, Cannon PM. PMID: 34563675; PMCID: PMC8571172.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Optimization of AAV6 transduction enhances site-specific genome editing of primary human lymphocytes. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:198-209.
Rogers GL, Huang C, Clark RDE, Seclén E, Chen HY, Cannon PM. PMID: 34703842; PMCID: PMC8517001.
View in:
PubMed Mentions:
20
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Cytoplasmic Tail Truncation of SARS-CoV-2 Spike Protein Enhances Titer of Pseudotyped Vectors but Masks the Effect of the D614G Mutation. J Virol. 2021 10 27; 95(22):e0096621.
Chen HY, Huang C, Tian L, Huang X, Zhang C, Llewellyn GN, Rogers GL, Andresen K, O'Gorman MRG, Chen YW, Cannon PM. PMID: 34495700; PMCID: PMC8549521.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Characterizing the Genetic Architecture of Parkinson's Disease in Latinos. Ann Neurol. 2021 09; 90(3):353-365.
Loesch DP, Horimoto ARVR, Heilbron K, Sarihan EI, Inca-Martinez M, Mason E, Cornejo-Olivas M, Torres L, Mazzetti P, Cosentino C, Sarapura-Castro E, Rivera-Valdivia A, Medina AC, Dieguez E, Raggio V, Lescano A, Tumas V, Borges V, Ferraz HB, Rieder CR, Schumacher-Schuh A, Santos-Lobato BL, Velez-Pardo C, Jimenez-Del-Rio M, Lopera F, Moreno S, Chana-Cuevas P, Fernandez W, Arboleda G, Arboleda H, Arboleda-Bustos CE, Yearout D, Zabetian CP, 23andMe Research Team, Cannon P, Thornton TA, O'Connor TD, Mata IF, Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD). PMID: 34227697; PMCID: PMC8457043.
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PubMed Mentions:
51 Fields:
Translation:
Humans
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Author Correction: The effect of LRRK2 loss-of-function variants in humans. Nat Med. 2021 Feb; 27(2):355.
Whiffin N, Armean IM, Kleinman A, Marshall JL, Minikel EV, Goodrich JK, Quaife NM, Cole JB, Wang Q, Karczewski KJ, Cummings BB, Francioli L, Laricchia K, Guan A, Alipanahi B, Morrison P, Baptista MAS, Merchant KM, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Ware JS, Havulinna AS, Iliadou B, Lee JJ, Nadkarni GN, Whiteman C, 23andMe Research Team, Daly M, Esko T, Hultman C, Loos RJF, Milani L, Palotie A, Pato C, Pato M, Saleheen D, Sullivan PF, Alföldi J, Cannon P, MacArthur DG. PMID: 33483629; PMCID: PMC8095267.
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PubMed Mentions: Fields:
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Safe and Effective In Vivo Targeting and Gene Editing in Hematopoietic Stem Cells: Strategies for Accelerating Development. Hum Gene Ther. 2021 01; 32(1-2):31-42.
Cannon P, Asokan A, Czechowicz A, Hammond P, Kohn DB, Lieber A, Malik P, Marks P, Porteus M, Verhoeyen E, Weissman D, Weissman I, Kiem HP. PMID: 33427035; PMCID: PMC8917879.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Investigating human eyelash hair follicle growth in situ and ex vivo: a pilot study. Br J Dermatol. 2021 03; 184(3):553-555.
Platt CI, Laybourne J, Cannon P, Paus R. PMID: 33006146.
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PubMed Mentions: Fields:
Translation:
Humans
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Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research. AIDS Res Hum Retroviruses. 2020 11; 36(11):883-885.
Hope TJ, Klatt NR, Sacha JB, Cannon PM. PMID: 33050710.
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PubMed Mentions: Fields:
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Rational Selection of CRISPR-Cas9 Guide RNAs for Homology-Directed Genome Editing. Mol Ther. 2021 Mar 03; 29(3):1057-1069.
Tatiossian KJ, Clark RDE, Huang C, Thornton ME, Grubbs BH, Cannon PM. PMID: 33160457; PMCID: PMC7934447.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Limited potential of AAV-mediated gene therapy in transducing human mesenchymal stem cells for bone repair applications. Gene Ther. 2021 12; 28(12):729-739.
Bougioukli S, Chateau M, Morales H, Vakhshori V, Sugiyama O, Oakes D, Longjohn D, Cannon P, Lieberman JR. PMID: 32807899.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
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The effect of LRRK2 loss-of-function variants in humans. Nat Med. 2020 06; 26(6):869-877.
Whiffin N, Armean IM, Kleinman A, Marshall JL, Minikel EV, Goodrich JK, Quaife NM, Cole JB, Wang Q, Karczewski KJ, Cummings BB, Francioli L, Laricchia K, Guan A, Alipanahi B, Morrison P, Baptista MAS, Merchant KM, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Ware JS, Havulinna AS, Iliadou B, Lee JJ, Nadkarni GN, Whiteman C, 23andMe Research Team, Daly M, Esko T, Hultman C, Loos RJF, Milani L, Palotie A, Pato C, Pato M, Saleheen D, Sullivan PF, Alföldi J, Cannon P, MacArthur DG. PMID: 32461697; PMCID: PMC7303015.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansCells
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SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder. Neurobiol Aging. 2020 09; 93:142.e5-142.e7.
Rudakou U, Futhey NC, Krohn L, Ruskey JA, Heilbron K, Cannon P, 23andMe Research Team, Alam A, Arnulf I, Hu MTM, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Toffoli M, Gigli GL, Valente M, Högl B, Stefani A, Holzknecht E, Sonka K, Kemlink D, Oertel W, Janzen A, Plazzi G, Antelmi E, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Döring F, De Cock VC, Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Postuma RB, Rouleau GA, Gan-Or Z. PMID: 32409254.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies. Ann Neurol. 2020 04; 87(4):584-598.
Krohn L, Wu RYJ, Heilbron K, Ruskey JA, Laurent SB, Blauwendraat C, Alam A, Arnulf I, Hu MTM, Dauvilliers Y, Högl B, Toft M, Bjørnarå KA, Stefani A, Holzknecht E, Monaca CC, Abril B, Plazzi G, Antelmi E, Ferini-Strambi L, Young P, Heidbreder A, Cochen De Cock V, Mollenhauer B, Sixel-Döring F, Trenkwalder C, Sonka K, Kemlink D, Figorilli M, Puligheddu M, Dijkstra F, Viaene M, Oertel W, Toffoli M, Gigli GL, Valente M, Gagnon JF, Nalls MA, Singleton AB, 23andMe Research Team, Desautels A, Montplaisir JY, Cannon P, Ross OA, Boeve BF, Dupré N, Fon EA, Postuma RB, Pihlstrøm L, Rouleau GA, Gan-Or Z. PMID: 31976583; PMCID: PMC8025046.
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PubMed Mentions:
27 Fields:
Translation:
Humans
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Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain. 2020 01 01; 143(1):234-248.
Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, Leonard HL, Grenn FP, Ruskey JA, Sabir M, Ahmed S, Makarious MB, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola-Rautio J, Tienari PJ, 23andMe Research Team, Pantelyat A, Hillis AE, Dawson TM, Rosenthal LS, Albert MS, Resnick SM, Ferrucci L, Morris CM, Pletnikova O, Troncoso J, Grosset D, Lesage S, Corvol JC, Brice A, Noyce AJ, Masliah E, Wood N, Hardy J, Shulman LM, Jankovic J, Shulman JM, Heutink P, Gasser T, Cannon P, Scholz SW, Morris H, Cookson MR, Nalls MA, Gan-Or Z, Singleton AB. PMID: 31755958; PMCID: PMC6935749.
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PubMed Mentions:
131 Fields:
Translation:
HumansCells
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Gene Editing Expands the Donor Pool for CCR5-Negative Stem Cell Transplants. Cell Stem Cell. 2019 12 05; 25(6):735-736.
Cannon PM. PMID: 31809736.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Reply to "Efficient Nuclease-free HR by Clade F AAV Requires High MOIs with High Quality Vectors". Mol Ther. 2019 12 04; 27(12):2061-2062.
Rogers GL, Chen HY, Morales H, Cannon PM. PMID: 31735602; PMCID: PMC6904797.
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PubMed Mentions: Fields:
Translation:
Cells
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Return to Employment after Critical Illness and Its Association with Psychosocial Outcomes. A Systematic Review and Meta-Analysis. Ann Am Thorac Soc. 2019 10; 16(10):1304-1311.
McPeake J, Mikkelsen ME, Quasim T, Hibbert E, Cannon P, Shaw M, Ankori J, Iwashyna TJ, Haines KJ. PMID: 31184500.
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PubMed Mentions:
45 Fields:
Translation:
Humans
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Homologous Recombination-Based Genome Editing by Clade F AAVs Is Inefficient in the Absence of a Targeted DNA Break. Mol Ther. 2019 10 02; 27(10):1726-1736.
Rogers GL, Chen HY, Morales H, Cannon PM. PMID: 31540849; PMCID: PMC6822228.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells. J Virol. 2019 05 15; 93(10).
Llewellyn GN, Seclén E, Wietgrefe S, Liu S, Chateau M, Pei H, Perkey K, Marsden MD, Hinkley SJ, Paschon DE, Holmes MC, Zack JA, Louie SG, Haase AT, Cannon PM. PMID: 30842333; PMCID: PMC6498059.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Reprogramming the antigen specificity of B cells using genome-editing technologies. Elife. 2019 01 17; 8.
Voss JE, Gonzalez-Martin A, Andrabi R, Fuller RP, Murrell B, McCoy LE, Porter K, Huang D, Li W, Sok D, Le K, Briney B, Chateau M, Rogers G, Hangartner L, Feeney AJ, Nemazee D, Cannon P, Burton DR. PMID: 30648968; PMCID: PMC6355199.
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PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Protect NIH's DNA advisory committee. Science. 2018 10 26; 362(6413):409-410.
Adelman ZN, Albritton LM, Boris-Lawrie K, Buchmeier MJ, Cannon P, Cho M, DiGiusto D, Donahue JK, Federoff HJ, Hammarskjold ML, Hardison AD, Hearing P, Lee B, Lee DA, Porteus MH, Ross LF, Ross SR, Wooley DP, Zoloth L. PMID: 30361364.
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PubMed Mentions: Fields:
Translation:
Humans
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HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol. 2018 04; 24(2):192-203.
Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM. PMID: 29256041; PMCID: PMC5910454.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Nat Biotechnol. 2018 01; 36(1):95-102.
Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D. PMID: 29176614; PMCID: PMC5762392.
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PubMed Mentions:
152 Fields:
Translation:
HumansAnimalsCells
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Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases. Hematol Oncol Clin North Am. 2017 10; 31(5):883-895.
Rogers GL, Cannon PM. PMID: 28895854.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression. Nat Commun. 2017 03 01; 8:14447.
Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS. PMID: 28248314; PMCID: PMC5337983.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Clinical Applications of Genome Editing to HIV Cure. AIDS Patient Care STDS. 2016 12; 30(12):539-544.
Wang CX, Cannon PM. PMID: 27854119; PMCID: PMC5144849.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells. Mol Ther Methods Clin Dev. 2016; 3:16067.
DiGiusto DL, Cannon PM, Holmes MC, Li L, Rao A, Wang J, Lee G, Gregory PD, Kim KA, Hayward SB, Meyer K, Exline C, Lopez E, Henley J, Gonzalez N, Bedell V, Stan R, Zaia JA. PMID: 27900346; PMCID: PMC5102145.
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PubMed Mentions:
52
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International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50.
Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. PMID: 27400264; PMCID: PMC5322797.
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PubMed Mentions:
282 Fields:
Translation:
Humans
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Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment. AIDS Patient Care STDS. 2016 07; 30(7):291-306.
Woodham AW, Skeate JG, Sanna AM, Taylor JR, Da Silva DM, Cannon PM, Kast WM. PMID: 27410493; PMCID: PMC4948215.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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The clinical applications of genome editing in HIV. Blood. 2016 05 26; 127(21):2546-52.
Wang CX, Cannon PM. PMID: 27053530; PMCID: PMC4882804.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? Pathog Immun. 2016; 1(1):154-164.
Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC. PMID: 27668293; PMCID: PMC5033048.
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PubMed Mentions:
26
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Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors. Nat Biotechnol. 2015 Dec; 33(12):1256-1263.
Wang J, Exline CM, DeClercq JJ, Llewellyn GN, Hayward SB, Li PW, Shivak DA, Surosky RT, Gregory PD, Holmes MC, Cannon PM. PMID: 26551060; PMCID: PMC4842001.
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PubMed Mentions:
172 Fields:
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Determinants in HIV-2 Env and tetherin required for functional interaction. Retrovirology. 2015 Aug 07; 12:67.
Exline CM, Yang SJ, Haworth KG, Rengarajan S, Lopez LA, Droniou ME, Seclen E, Cannon PM. PMID: 26248668; PMCID: PMC4528709.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening. J Virol. 2015 Aug; 89(16):8428-43.
Rathbun JY, Droniou ME, Damoiseaux R, Haworth KG, Henley JE, Exline CM, Choe H, Cannon PM. PMID: 26041296; PMCID: PMC4524252.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Genome editing technologies: defining a path to clinic. Mol Ther. 2015 May; 23(5):796-806.
Corrigan-Curay J, O'Reilly M, Kohn DB, Cannon PM, Bao G, Bushman FD, Carroll D, Cathomen T, Joung JK, Roth D, Sadelain M, Scharenberg AM, von Kalle C, Zhang F, Jambou R, Rosenthal E, Hassani M, Singh A, Porteus MH. PMID: 25943494; PMCID: PMC4427885.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. Nature. 2015 Mar 05; 519(7541):87-91.
Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M. PMID: 25707797; PMCID: PMC4352131.
View in:
PubMed Mentions:
188 Fields:
Translation:
AnimalsCells
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HIV eradication--from Berlin to Boston. Nat Biotechnol. 2014 Apr; 32(4):315-6.
Cannon PM, Kohn DB, Kiem HP. PMID: 24714473.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice. J Infect Dis. 2013 Nov; 208 Suppl 2:S160-4.
Hofer U, Henley JE, Exline CM, Mulhern O, Lopez E, Cannon PM. PMID: 24151324; PMCID: PMC3807977.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther. 2013 Jun; 21(6):1259-69.
Li L, Krymskaya L, Wang J, Henley J, Rao A, Cao LF, Tran CA, Torres-Coronado M, Gardner A, Gonzalez N, Kim K, Liu PQ, Hofer U, Lopez E, Gregory PD, Liu Q, Holmes MC, Cannon PM, Zaia JA, DiGiusto DL. PMID: 23587921; PMCID: PMC3677314.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
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A systems biology starter kit for arenaviruses. Viruses. 2012 Dec; 4(12):3625-46.
Droniou-Bonzom ME, Cannon PM. PMID: 23342371; PMCID: PMC3528283.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Anti-tetherin activities of HIV-1 Vpu and Ebola virus glycoprotein do not involve removal of tetherin from lipid rafts. J Virol. 2012 May; 86(10):5467-80.
Lopez LA, Yang SJ, Exline CM, Rengarajan S, Haworth KG, Cannon PM. PMID: 22398279; PMCID: PMC3347301.
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32 Fields:
Translation:
HumansCells
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Substitutions in the glycoprotein (GP) of the Candid#1 vaccine strain of Junin virus increase dependence on human transferrin receptor 1 for entry and destabilize the metastable conformation of GP. J Virol. 2011 Dec; 85(24):13457-62.
Droniou-Bonzom ME, Reignier T, Oldenburg JE, Cox AU, Exline CM, Rathbun JY, Cannon PM. PMID: 21976641; PMCID: PMC3233171.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Lack of adaptation to human tetherin in HIV-1 group O and P. Retrovirology. 2011 Sep 28; 8:78.
Yang SJ, Lopez LA, Exline CM, Haworth KG, Cannon PM. PMID: 21955466; PMCID: PMC3192746.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Chemokine receptor 5 knockout strategies. Curr Opin HIV AIDS. 2011 Jan; 6(1):74-9.
Cannon P, June C. PMID: 21242897; PMCID: PMC3066441.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010 Aug; 28(8):839-47.
Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, Crooks GM, Kohn DB, Gregory PD, Holmes MC, Cannon PM. PMID: 20601939; PMCID: PMC3080757.
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PubMed Mentions:
374 Fields:
Translation:
HumansAnimalsCells
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HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology. 2010 Jun 07; 7:51.
Hauser H, Lopez LA, Yang SJ, Oldenburg JE, Exline CM, Guatelli JC, Cannon PM. PMID: 20529266; PMCID: PMC2890665.
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PubMed Mentions:
120 Fields:
Translation:
HumansCells
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Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal. J Virol. 2010 Jul; 84(14):7243-55.
Lopez LA, Yang SJ, Hauser H, Exline CM, Haworth KG, Oldenburg J, Cannon PM. PMID: 20444895; PMCID: PMC2898217.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Anti-tetherin activities in Vpu-expressing primate lentiviruses. Retrovirology. 2010 Feb 18; 7:13.
Yang SJ, Lopez LA, Hauser H, Exline CM, Haworth KG, Cannon PM. PMID: 20167081; PMCID: PMC2831821.
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58 Fields:
Translation:
HumansAnimalsCells
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Vpu-dependent block to incorporation of GaLV Env into lentiviral vectors. Retrovirology. 2010 Jan 26; 7:4.
Christodoulopoulos I, Droniou-Bonzom ME, Oldenburg JE, Cannon PM. PMID: 20102634; PMCID: PMC2831008.
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PubMed Mentions:
11 Fields:
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HumansCells
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Pseudotyping incompatibility between HIV-1 and gibbon ape leukemia virus Env is modulated by Vpu. J Virol. 2010 Mar; 84(6):2666-74.
Lucas TM, Lyddon TD, Cannon PM, Johnson MC. PMID: 20042505; PMCID: PMC2826068.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells, using the Sleeping Beauty transposon system. Hum Gene Ther. 2009 Dec; 20(12):1607-26.
Sumiyoshi T, Holt NG, Hollis RP, Ge S, Cannon PM, Crooks GM, Kohn DB. PMID: 19689196; PMCID: PMC4094131.
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PubMed Mentions:
24 Fields:
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HumansAnimalsCells
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Investigation of clade B New World arenavirus tropism by using chimeric GP1 proteins. J Virol. 2010 Jan; 84(2):1176-82.
Martin VK, Droniou-Bonzom ME, Reignier T, Oldenburg JE, Cox AU, Cannon PM. PMID: 19889757; PMCID: PMC2798354.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Tissue-specific restriction of cyclophilin A-independent HIV-1- and SIV-derived lentiviral vectors. Gene Ther. 2008 Aug; 15(15):1079-89.
Kahl CA, Cannon PM, Oldenburg J, Tarantal AF, Kohn DB. PMID: 18385767.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1. J Virol. 2008 Jan; 82(2):938-48.
Flanagan ML, Oldenburg J, Reignier T, Holt N, Hamilton GA, Martin VK, Cannon PM. PMID: 18003730; PMCID: PMC2224602.
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PubMed Mentions:
80 Fields:
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HumansAnimalsCells
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Receptor use by the Whitewater Arroyo virus glycoprotein. Virology. 2008 Feb 20; 371(2):439-46.
Reignier T, Oldenburg J, Flanagan ML, Hamilton GA, Martin VK, Cannon PM. PMID: 17997467; PMCID: PMC2270610.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Promoter choice for retroviral vectors: transcriptional strength versus trans-activation potential. Hum Gene Ther. 2007 Sep; 18(9):849-60.
Weber EL, Cannon PM. PMID: 17767401.
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14 Fields:
Translation:
HumansCells
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Differences in tropism and pH dependence for glycoproteins from the Clade B1 arenaviruses: implications for receptor usage and pathogenicity. Virology. 2007 Jul 20; 364(1):132-9.
Oldenburg J, Reignier T, Flanagan ML, Hamilton GA, Cannon PM. PMID: 17397892; PMCID: PMC2743526.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Receptor use by pathogenic arenaviruses. Virology. 2006 Sep 15; 353(1):111-20.
Reignier T, Oldenburg J, Noble B, Lamb E, Romanowski V, Buchmeier MJ, Cannon PM. PMID: 16797051.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Recruitment of the adaptor protein 2 complex by the human immunodeficiency virus type 2 envelope protein is necessary for high levels of virus release. J Virol. 2006 Mar; 80(6):2924-32.
Noble B, Abada P, Nunez-Iglesias J, Cannon PM. PMID: 16501101; PMCID: PMC1395462.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Functional domains within the human immunodeficiency virus type 2 envelope protein required to enhance virus production. J Virol. 2005 Mar; 79(6):3627-38.
Abada P, Noble B, Cannon PM. PMID: 15731257; PMCID: PMC1075700.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Cytoplasmic tail of Moloney murine leukemia virus envelope protein influences the conformation of the extracellular domain: implications for mechanism of action of the R Peptide. J Virol. 2003 Jan; 77(2):1281-91.
Aguilar HC, Anderson WF, Cannon PM. PMID: 12502845; PMCID: PMC140788.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet. 2002 Dec; 32(4):670-5.
Chen M, Kasahara N, Keene DR, Chan L, Hoeffler WK, Finlay D, Barcova M, Cannon PM, Mazurek C, Woodley DT. PMID: 12426566.
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PubMed Mentions:
59 Fields:
Translation:
HumansCells
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Use of pseudotyped retroviral vectors to analyze the receptor-binding pocket of hemagglutinin from a pathogenic avian influenza A virus (H7 subtype). Virus Res. 2002 Feb 26; 83(1-2):43-56.
Lin AH, Cannon PM. PMID: 11864740.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells. J Virol. 2001 Dec; 75(23):11747-54.
Borok Z, Harboe-Schmidt JE, Brody SL, You Y, Zhou B, Li X, Cannon PM, Kim KJ, Crandall ED, Kasahara N. PMID: 11689655; PMCID: PMC114760.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Retroviral vectors bearing IgG-binding motifs for antibody-mediated targeting of vascular endothelial growth factor receptors. Int J Mol Med. 2001 Oct; 8(4):335-43.
Masood R, Gordon EM, Whitley MD, Wu BW, Cannon P, Evans L, Anderson WF, Gill P, Hall FL. PMID: 11562769.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary. J Virol. 2001 Aug; 75(15):6989-98.
Logg CR, Logg A, Tai CK, Cannon PM, Kasahara N. PMID: 11435579; PMCID: PMC114427.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Sequences in the cytoplasmic tail of the gibbon ape leukemia virus envelope protein that prevent its incorporation into lentivirus vectors. J Virol. 2001 May; 75(9):4129-38.
Christodoulopoulos I, Cannon PM. PMID: 11287562; PMCID: PMC114158.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein. Hum Gene Ther. 2001 Mar 01; 12(4):323-32.
Lin AH, Kasahara N, Wu W, Stripecke R, Empig CL, Anderson WF, Cannon PM. PMID: 11242525.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Identification of regions in the Moloney murine leukemia virus SU protein that tolerate the insertion of an integrin-binding peptide. Virology. 2000 Mar 30; 269(1):7-17.
Wu BW, Lu J, Gallaher TK, Anderson WF, Cannon PM. PMID: 10725193.
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22 Fields:
Translation:
HumansAnimalsCells
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Targeting retroviral vectors to CD34-expressing cells: binding to CD34 does not catalyze virus-cell fusion. Hum Gene Ther. 1999 Mar 01; 10(4):545-57.
Benedict CA, Tun RY, Rubinstein DB, Guillaume T, Cannon PM, Anderson WF. PMID: 10094198.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Role of variable regions A and B in receptor binding domain of amphotropic murine leukemia virus envelope protein. J Virol. 1998 Nov; 72(11):9101-8.
Han JY, Zhao Y, Anderson WF, Cannon PM. PMID: 9765455; PMCID: PMC110327.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Characterization of the proline-rich region of murine leukemia virus envelope protein. J Virol. 1998 Jul; 72(7):5383-91.
Weimin Wu B, Cannon PM, Gordon EM, Hall FL, Anderson WF. PMID: 9620992; PMCID: PMC110165.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Functional domains in the retroviral transmembrane protein. J Virol. 1998 Jul; 72(7):5392-8.
Zhao Y, Zhu L, Benedict CA, Chen D, Anderson WF, Cannon PM. PMID: 9620993; PMCID: PMC110168.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Mutational analysis of the fusion peptide of Moloney murine leukemia virus transmembrane protein p15E. J Virol. 1998 Feb; 72(2):1632-9.
Zhu NL, Cannon PM, Chen D, Anderson WF. PMID: 9445069; PMCID: PMC124647.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Identification of envelope protein residues required for the expanded host range of 10A1 murine leukemia virus. J Virol. 1997 Nov; 71(11):8103-8.
Han JY, Cannon PM, Lai KM, Zhao Y, Eiden MV, Anderson WF. PMID: 9343159; PMCID: PMC192265.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Structure-function studies of the human immunodeficiency virus type 1 matrix protein, p17. J Virol. 1997 May; 71(5):3474-83.
Cannon PM, Matthews S, Clark N, Byles ED, Iourin O, Hockley DJ, Kingsman SM, Kingsman AJ. PMID: 9094619; PMCID: PMC191494.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Functional analysis of the cytoplasmic tail of Moloney murine leukemia virus envelope protein. J Virol. 1997 May; 71(5):3613-9.
Januszeski MM, Cannon PM, Chen D, Rozenberg Y, Anderson WF. PMID: 9094634; PMCID: PMC191509.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy. J Virol. 1996 Nov; 70(11):8234-40.
Cannon PM, Kim N, Kingsman SM, Kingsman AJ. PMID: 8892960; PMCID: PMC190909.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication. J Virol. 1996 Jan; 70(1):651-7.
Cannon PM, Byles ED, Kingsman SM, Kingsman AJ. PMID: 8523588; PMCID: PMC189861.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res. 1995 Feb 25; 23(4):628-33.
Soneoka Y, Cannon PM, Ramsdale EE, Griffiths JC, Romano G, Kingsman SM, Kingsman AJ. PMID: 7899083; PMCID: PMC306730.
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PubMed Mentions:
306 Fields:
Translation:
HumansAnimalsCells
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Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues. J Virol. 1994 Aug; 68(8):4768-75.
Cannon PM, Wilson W, Byles E, Kingsman SM, Kingsman AJ. PMID: 8035478; PMCID: PMC236416.
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PubMed Mentions:
53 Fields:
Translation:
HumansCells
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Analysis of Tat function in human immunodeficiency virus type 1-infected low-level-expression cell lines U1 and ACH-2. J Virol. 1994 Mar; 68(3):1993-7.
Cannon P, Kim SH, Ulich C, Kim S. PMID: 8107261; PMCID: PMC236665.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Inhibition of human immunodeficiency virus type 1 Tat-dependent activation of translation in Xenopus oocytes by the benzodiazepine Ro24-7429 requires trans-activation response element loop sequences. J Virol. 1994 Jan; 68(1):25-33.
Braddock M, Cannon P, Muckenthaler M, Kingsman AJ, Kingsman SM. PMID: 8254735; PMCID: PMC236260.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Human immunodeficiency virus-1 infection of the human promyelocytic cell line HL-60: high frequency of low-level infection and effect of subsequent cell differentiation. Blood. 1993 Jan 15; 81(2):437-45.
Cannon PM, Tenen DG, Feinberg MB, Shin HS, Kim S. PMID: 8422463.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Chimeric gag-V3 virus-like particles of human immunodeficiency virus induce virus-neutralizing antibodies. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10527-31.
Luo L, Li Y, Cannon PM, Kim S, Kang CY. PMID: 1438241; PMCID: PMC50372.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells