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Giselle M Petzinger, MD

Title(s)Associate Professor of Neurology (Clinical Scholar)
AddressHCC 3000
Health Sciences Campus
Los Angeles CA 90089-9405
Phone+1 323 442 5728
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    Dr. Petzinger is a board certified neurologist specializing in the care of patients with Parkinson’s disease. She divides her time between clinical care of patients and laboratory research. The primary focus of Dr. Petzinger’s research is to better understand how to promote brain repair following injury and to translate these findings into new therapeutic treatments. Dr. Petzinger has been involved in numerous federally funded research grants. Currently, she is the principal investigator on the US Army Research Grant entitled Behaviorial and Pharmacolgical Enhancement of Neuroplasticity in Basal Ganglia of the MPTP-Lesioned Mouse and Non-Human Primate.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Exogenous l-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor behavior in mice. J Neurosci Res. 2021 Feb 25. Lundquist AJ, Gallagher TJ, Petzinger GM, Jakowec MW. PMID: 33629362.
      View in: PubMed   Mentions:    Fields:    
    2. Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease. Mov Disord. 2021 Jan 20. Donahue EK, Murdos A, Jakowec MW, Sheikh-Bahaei N, Toga AW, Petzinger GM, Sepehrband F. PMID: 33470460.
      View in: PubMed   Mentions:    Fields:    
    3. Cognitive flexibility deficits in rats with dorsomedial striatal 6-hydroxydopamine lesions tested using a three-choice serial reaction time task with reversal learning. Neuroreport. 2020 Oct 14; 31(15):1055-1064. Wang Z, Flores I, Donahue EK, Lundquist AJ, Guo Y, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 32881776.
      View in: PubMed   Mentions:    Fields:    
    4. Mild cognitive impairment, psychiatric symptoms, and executive functioning in patients with Parkinson's disease. Int J Geriatr Psychiatry. 2020 04; 35(4):396-404. Petkus AJ, Filoteo JV, Schiehser DM, Gomez ME, Hui JS, Jarrahi B, McEwen S, Jakowec MW, Petzinger GM. PMID: 31894601.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease. Chem Biol Interact. 2020 Jan 05; 315:108907. Caldwell CC, Petzinger GM, Jakowec MW, Cadenas E. PMID: 31778667.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Intensive treadmill exercise increases expression of hypoxia-inducible factor 1a and its downstream transcript targets: a potential role in neuroplasticity. Neuroreport. 2019 06 12; 30(9):619-627. Halliday MR, Abeydeera D, Lundquist AJ, Petzinger GM, Jakowec MW. PMID: 31045849.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Exercise induces region-specific remodeling of astrocyte morphology and reactive astrocyte gene expression patterns in male mice. J Neurosci Res. 2019 09; 97(9):1081-1094. Lundquist AJ, Parizher J, Petzinger GM, Jakowec MW. PMID: 31175682.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Worse cognitive performance predicts increased anxiety and depressive symptoms in patients with Parkinson's disease: A bidirectional analysis. Neuropsychology. 2019 Jan; 33(1):35-46. Petkus AJ, Filoteo JV, Schiehser DM, Gomez ME, Petzinger G. PMID: 30335414.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Basal ganglia and beyond: The interplay between motor and cognitive aspects in Parkinson's disease rehabilitation. Neurosci Biobehav Rev. 2018 07; 90:294-308. Ferrazzoli D, Ortelli P, Madeo G, Giladi N, Petzinger GM, Frazzitta G. PMID: 29733882.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    10. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. PMID: 29270905.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    11. Treadmill exercise modifies dopamine receptor expression in the prefrontal cortex of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease. Neuroreport. 2017 Oct 18; 28(15):987-995. Kintz N, Petzinger GM, Jakowec MW. PMID: 28877102.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Treadmill exercise delays the onset of non-motor behaviors and striatal pathology in the CAG140 knock-in mouse model of Huntington's disease. Neurobiol Dis. 2017 Sep; 105:15-32. PMID: 28502806.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Noradrenergic mechanisms of arousal's bidirectional effects on episodic memory. Neurobiol Learn Mem. 2017 Jan; 137:1-14. PMID: 27815214.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Engaging cognitive circuits to promote motor recovery in degenerative disorders. exercise as a learning modality. J Hum Kinet. 2016 Sep 01; 52:35-51. PMID: 28149392.
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    15. Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease. Neuroreport. 2016 06 15; 27(9):632-9. PMID: 27082842.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. Context-Dependent Learning in People With Parkinson's Disease. J Mot Behav. 2016 May-Jun; 48(3):240-8. PMID: 26375786.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Personality traits and the risk for Parkinson disease: a prospective study. Eur J Epidemiol. 2016 Feb; 31(2):169-75. PMID: 26130127.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    18. The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry. Brain Plast. 2015; 1(1):29-39. PMID: 26512345.
      View in: PubMed   Mentions:
    19. A kinder, gentler dopamine… highlighting dopamine's role in behavioral flexibility. Front Neurosci. 2014; 8:4. PMID: 24478624.
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    20. Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Neurobiol Dis. 2014 Mar; 63:201-9. PMID: 24316165.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    21. The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson's Disease. Front Neurol. 2013; 4:134. PMID: 24062721.
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    22. Exercise modifies a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor expression in striatopallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse. J Neurosci Res. 2013 Nov; 91(11):1492-507. PMID: 23918451.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease. Neuroreport. 2013 Jul 10; 24(10):509-14. PMID: 23636255.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    24. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease. Lancet Neurol. 2013 Jul; 12(7):716-26. PMID: 23769598.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    25. Brief mitochondrial inhibition causes lasting changes in motor behavior and corticostriatal synaptic physiology in the Fischer 344 rat. Neuroscience. 2012 Jul 26; 215:149-59. PMID: 22554779.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Accuracy and sensitivity of Parkinsonian disorder diagnoses in two Swedish national health registers. Neuroepidemiology. 2012; 38(3):186-93. PMID: 22472568.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    27. How might physical activity benefit patients with Parkinson disease? Nat Rev Neurol. 2011 Jul 12; 7(9):528-34. PMID: 21750523.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    28. MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse. Parkinsons Dis. 2011; 2011:138471. PMID: 21765998.
      View in: PubMed   Mentions:
    29. The role of exercise in facilitating basal ganglia function in Parkinson's disease. Neurodegener Dis Manag. 2011 Apr 01; 1(2):157-170. PMID: 23805167.
      View in: PubMed   Mentions: 3     Fields:    
    30. Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹8F]fallypride. Mov Disord. 2010 Dec 15; 25(16):2777-84. Vuckovic MG, Li Q, Fisher B, Nacca A, Leahy RM, Walsh JP, Mukherjee J, Williams C, Jakowec MW, Petzinger GM. PMID: 20960487.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    31. Acute and long-term response of dopamine nigrostriatal synapses to a single, low-dose episode of 3-nitropropionic acid-mediated chemical hypoxia. Synapse. 2011 Apr; 65(4):339-50. Crawford CA, Akopian G, Ring J, Jakowec MW, Petzinger GM, Andersen JK, Vittozzi-Wong P, Wang K, Farley CM, Charntikov S, Mitroi D, Beal MF, Chow R, Walsh JP. PMID: 20730800.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse. Behav Brain Res. 2010 Dec 01; 213(2):253-62. Gorton LM, Vuckovic MG, Vertelkina N, Petzinger GM, Jakowec MW, Wood RI. PMID: 20472000.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    33. Sex differences in motor behavior in the MPTP mouse model of Parkinson's disease. Pharmacol Biochem Behav. 2010 Jun; 95(4):466-72. Antzoulatos E, Jakowec MW, Petzinger GM, Wood RI. PMID: 20347863.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    34. Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci Res. 2010 Feb 15; 88(3):650-68. VanLeeuwen JE, Petzinger GM, Walsh JP, Akopian GK, Vuckovic M, Jakowec MW. PMID: 19746427.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    35. Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease. Mov Disord. 2010; 25 Suppl 1:S141-5. Petzinger GM, Fisher BE, Van Leeuwen JE, Vukovic M, Akopian G, Meshul CK, Holschneider DP, Nacca A, Walsh JP, Jakowec MW. PMID: 20187247.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    36. The relationships between the unified Parkinson's disease rating scale and lower extremity functional performance in persons with early-stage Parkinson's disease. Neurorehabil Neural Repair. 2009 Sep; 23(7):657-61. Song J, Fisher BE, Petzinger G, Wu A, Gordon J, Salem GJ. PMID: 19336530.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia. J Neurosci. 2008 Sep 17; 28(38):9585-97. Akopian G, Crawford C, Beal MF, Cappelletti M, Jakowec MW, Petzinger GM, Zheng L, Gheorghe SL, Reichel CM, Chow R, Walsh JP. PMID: 18799690.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol Dis. 2008 Nov; 32(2):319-27. Vuckovic MG, Wood RI, Holschneider DP, Abernathy A, Togasaki DM, Smith A, Petzinger GM, Jakowec MW. PMID: 18718537.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    39. The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch Phys Med Rehabil. 2008 Jul; 89(7):1221-9. Fisher BE, Wu AD, Salem GJ, Song J, Lin CH, Yip J, Cen S, Gordon J, Jakowec M, Petzinger G. PMID: 18534554.
      View in: PubMed   Mentions: 101     Fields:    Translation:Humans
    40. Asymmetric corticomotor excitability correlations in early Parkinson's disease. Mov Disord. 2007 Aug 15; 22(11):1587-93. Wu AD, Petzinger GM, Lin CH, Kung M, Fisher B. PMID: 17523196.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    41. Complete ascertainment of Parkinson disease in the Swedish Twin Registry. Neurobiol Aging. 2008 Dec; 29(12):1765-73. Wirdefeldt K, Gatz M, Bakaysa SL, Fiske A, Flensburg M, Petzinger GM, Widner H, Lew MF, Welsh M, Pedersen NL. PMID: 17532098.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    42. Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci. 2007 May 16; 27(20):5291-300. Petzinger GM, Walsh JP, Akopian G, Hogg E, Abernathy A, Arevalo P, Turnquist P, Vuckovic M, Fisher BE, Togasaki DM, Jakowec MW. PMID: 17507552.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    43. Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. J Neurosci Res. 2006 Feb 01; 83(2):332-47. Petzinger GM, Fisher B, Hogg E, Abernathy A, Arevalo P, Nixon K, Jakowec MW. PMID: 16385585.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    44. High and low responders to novelty show differential effects in striatal glutamate. Synapse. 2005 Dec 01; 58(3):200-7. Shakil SS, Holmer HK, Moore C, Abernathy AT, Jakowec MW, Petzinger GM, Meshul CK. PMID: 16138315.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    45. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates. Comp Med. 2004 Oct; 54(5):497-513. Jakowec MW, Petzinger GM. PMID: 15575363.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    46. Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia. J Neurosci Res. 2004 Aug 01; 77(3):378-90. Fisher BE, Petzinger GM, Nixon K, Hogg E, Bremmer S, Meshul CK, Jakowec MW. PMID: 15248294.
      View in: PubMed   Mentions: 92     Fields:    Translation:Animals
    47. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. J Neurosci Res. 2004 May 15; 76(4):539-50. Jakowec MW, Nixon K, Hogg E, McNeill T, Petzinger GM. PMID: 15114626.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    48. Human neural stem cell transplantation in the MPTP-lesioned mouse. Brain Res. 2003 May 09; 971(2):168-77. Liker MA, Petzinger GM, Nixon K, McNeill T, Jakowec MW. PMID: 12706233.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    49. Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PD. Neurology. 2002 May 14; 58(9):1435-6. Woulfe JM, Duke R, Middeldorp JM, Stevens S, Vervoort M, Hashimoto M, Masliah E, Chan P, Di Monte DA, Langston JW, Petzinger G, Hoogendoorn H, Munoz DG. PMID: 12011302.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    50. The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety. J Neurochem. 2001 Mar; 76(5):1265-74. Przedborski S, Jackson-Lewis V, Naini AB, Jakowec M, Petzinger G, Miller R, Akram M. PMID: 11238711.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimals
    51. Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate. Mov Disord. 2001 Mar; 16(2):202-7. Petzinger GM, Quik M, Ivashina E, Jakowec MW, Jakubiak M, Di Monte D, Langston JW. PMID: 11295771.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    52. Postnatal expression of alpha-synuclein protein in the rodent substantia nigra and striatum. Dev Neurosci. 2001; 23(2):91-9. Jakowec MW, Donaldson DM, Barba J, Petzinger GM. PMID: 11509831.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    53. Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model. Mov Disord. 2000 May; 15(3):459-66. Di Monte DA, McCormack A, Petzinger G, Janson AM, Quik M, Langston WJ. PMID: 10830409.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    54. Combined assessment of tau and neuronal thread protein in Alzheimer's disease CSF. Neurology. 2000 Apr 11; 54(7):1498-504. Kahle PJ, Jakowec M, Teipel SJ, Hampel H, Petzinger GM, Di Monte DA, Silverberg GD, Möller HJ, Yesavage JA, Tinklenberg JR, Shooter EM, Murphy GM. PMID: 10751266.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    55. Investigating levodopa-induced dyskinesias in the parkinsonian primate. Ann Neurol. 2000 Apr; 47(4 Suppl 1):S79-89. Langston JW, Quik M, Petzinger G, Jakowec M, Di Monte DA. PMID: 10762135.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    56. Experimental models of Parkinson's disease: insights from many models. Lab Anim Sci. 1999 Aug; 49(4):363-71. Tolwani RJ, Jakowec MW, Petzinger GM, Green S, Waggie K. PMID: 10480640.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    57. The native form of alpha-synuclein is not found in the cerebrospinal fluid of patients with Parkinson's disease or normal controls. Neurosci Lett. 1998 Aug 28; 253(1):13-6. Jakowec MW, Petzinger GM, Sastry S, Donaldson DM, McCormack A, Langston JW. PMID: 9754793.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    58. A case of tetrabenazine-induced neuroleptic malignant syndrome after prolonged treatment. Mov Disord. 1997 Mar; 12(2):246-8. Petzinger GM, Bressman SB. PMID: 9087987.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    59. Use of intrathecal baclofen in the treatment of patients with dystonia. Arch Neurol. 1996 Dec; 53(12):1241-6. Ford B, Greene P, Louis ED, Petzinger G, Bressman SB, Goodman R, Brin MF, Sadiq S, Fahn S. PMID: 8970452.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    60. Fentanyl-induced dyskinesias. Mov Disord. 1995 Sep; 10(5):679-80. Petzinger G, Mayer SA, Przedborski S. PMID: 8552126.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    61. Potential misidentification of trichlorophenylethanol in imported peppers. Rapid Commun Mass Spectrom. 1990 Feb; 4(2):58-60. Cairns T, Siegmund EG, Barry TL, Petzinger G. PMID: 2134339.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    62. Thermospray mass spectrometry of thiazides. A novel elimination and rearrangement resulting from a molecular adduct ion. Rapid Commun Mass Spectrom. 1988 Feb; 2(2):25-7. Cairns T, Siegmund EG, Stamp JJ, Barry TL, Petzinger G. PMID: 2577840.
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