Nasim Sheikh-Bahaei, MD, PhD

Title(s)Assistant Professor of Clinical Radiology and Neurology
SchoolKeck School of Medicine of Usc
Address1500 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0001-7029-7215 Additional info
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    Other Positions
    Title(s)Associate Section Chief of Neuroradiology

    Collapse Biography 
    Collapse Awards and Honors
    Western Neuroradiological Society2018Gabriel H Wilson Award
    Cambridge University2016EG Fearnside Scholarship
    Cambridge University Hospitals2013Charles Freer Scholarship

    Collapse Overview 
    Collapse Overview
    Dr. Sheikh-Bahaei is a double board-certified physician in internal medicine and radiology with subspecialty training in neuroradiology. She received her M.D. from Tehran University of Medical Sciences and her PhD on Alzheimer’s disease (AD) imaging from University of Cambridge, U.K. Her PhD was a multimodality imaging study focusing on positron emission tomography (PET), MR spectroscopy (MRS) and susceptibility weighted imaging (SWI) in AD, funded by National Institute for Health Research (NIHR).
    Dr. Sheikh-Bahaei’s main research interest is the imaging biomarkers for diagnosis and prognosis of different neurodegenerative diseases and dementias utilizing advanced MRI techniques and PET scans with various tracers for metabolism, amyloid and tau. She is currently a Co-Investigator in the imaging core of Alzheimer’s disease research center (ADRC) at USC and working on different imaging cohorts at Laboratory of Neuroimaging (LONI) and ADRC. Her active research studies are:
    • Neurodegenerative diseases including AD, Primary Progressive aphasia and PDD/DLB.
    a. Synaptic function in Alzheimer’s disease and its association with amyloid beta and tau proteins.
    b. Interaction between the level of different neurotransmitters measured by MRS and function and density of synapses and their relationship with tractography in AD.
    c. Development of new tracers for AD and other dementias and optimizing the production of current tracers and improving the quality of PET images and establishing a semi-automated high-quality quantitative PET analysis system.
    • The role of microvascular changes (i.e. cerebral microbleeds, perivascular spaces and white matter changes) in different neurological disorders including:
    a. Alzheimer’s disease and other dementias: investigating the interaction between vascular changes and proteinopathy in AD. She was involved in developing an automated software for quantification of perivascular spaces at USC and currently working on a new atlas for normal and abnormal distribution of perivascular spaces across the life span.
    b. Migraine and other headaches, using 7T MRI to investigate the microvascular changes, perfusion and functional alteration in different types of Migraine.
    c. Normal pressure hydrocephalus, Idiopathic intracranial hypertension and Spontaneous intracranial hypotension; investigating the glymphatic system and perivascular spaces and the role of CSF clearance in various disorders associated with CSF flow impairment

    Collapse Research 
    Collapse Research Activities and Funding
    Vascular and Connectivity changes in chronic migraines and episodic migraines without aura using ultra high field MRI
    Center for Image Acquisition PG-7TMRIFeb 26, 2020 - Feb 26, 2021
    Role: Principal Investogator
    Motor, Visual, and Olfactory Changes in Genetic Subtypes of Alzheimer?s Disease
    NIH R01AG062007Feb 15, 2019 - Nov 30, 2023
    Role: Co-Investigator
    Alzheimer Disease Research Center
    NIH 5P50AG005142-35Apr 15, 1997 - Mar 31, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease. Methods Mol Biol. 2024; 2785:115-142. Sheikh-Bahaei N. PMID: 38427192.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Age of onset predicted by Aβ profiling in a novel PSEN1 (I180F) mutation. Neurosci Lett. 2024 Jan 18; 820:137591. Robbie L, Fernández SG, Montoya L, Sagare A, Barrera L, Sheikh-Bahaei N, Gutierrez LC, Ringman JM. PMID: 38103630.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Functional MRI and Diffusion Tensor Imaging in Migraine: A Review of Migraine Functional and White Matter Microstructural Changes. J Cent Nerv Syst Dis. 2023; 15:11795735231205413. Chou BC, Lerner A, Barisano G, Phung D, Xu W, Pinto SN, Sheikh-Bahaei N. PMID: 37900908; PMCID: PMC10612465.
      View in: PubMed   Mentions:
    4. Perivascular spaces in Alzheimer's disease are associated with inflammatory, stress-related, and hypertension biomarkers. bioRxiv. 2023 Jun 05. Sibilia F, Sheikh-Bahaei N, Mack WJ, Choupan J, Alzheimer’s Disease Neuroimaging Initiative. PMID: 37333097; PMCID: PMC10274635.
      View in: PubMed   Mentions:
    5. Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma. J Cent Nerv Syst Dis. 2023; 15:11795735231167868. Xu WJ, Barisano G, Phung D, Chou B, Pinto SN, Lerner A, Sheikh-Bahaei N. PMID: 37077432; PMCID: PMC10108417.
      View in: PubMed   Mentions:
    6. Characterization of spastic paraplegia in a family with a novel PSEN1 mutation. Brain Commun. 2023; 5(2):fcad030. Ringman JM, Dorrani N, Fernández SG, Signer R, Martinez-Agosto J, Lee H, Douine ED, Qiao Y, Shi Y, D'Orazio L, Pawar S, Robbie L, Kashani AH, Singer M, Byers JT, Magaki S, Guzman S, Sagare A, Zlokovic B, Cederbaum S, Nelson S, Sheikh-Bahaei N, Chui HC, Chávez-Gutiérrez L, Vinters HV. PMID: 36895955; PMCID: PMC9991506.
      View in: PubMed   Mentions: 1  
    7. White matter degradation near cerebral microbleeds is associated with cognitive change after mild traumatic brain injury. Neurobiol Aging. 2022 12; 120:68-80. Irimia A, Ngo V, Chaudhari NN, Zhang F, Joshi SH, Penkova AN, O'Donnell LJ, Sheikh-Bahaei N, Zheng X, Chui HC. PMID: 36116396.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Utility of Neuroimaging in the Management of Chronic and Acute Headache. Otolaryngol Clin North Am. 2022 Jun; 55(3):559-577. Lerner A, Sheikh-Bahaei N, Go JL. PMID: 35490044.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Dementia is associated with medial temporal atrophy even after accounting for neuropathologies. Brain Commun. 2022; 4(2):fcac052. Woodworth DC, Sheikh-Bahaei N, Scambray KA, Phelan MJ, Perez-Rosendahl M, Corrada MM, Kawas CH, Sajjadi SA, Alzheimer's Disease Neuroimaging Initiative. PMID: 35350552; PMCID: PMC8952251.
      View in: PubMed   Mentions: 9  
    10. Neuroimaging Features of Intracranial Hypertension in Pediatric Patients With New-Onset Idiopathic Seizures, a Comparison With Patients with Confirmed Diagnosis of Idiopathic Intracranial Hypertension: A Preliminary Study. J Child Neurol. 2021 10; 36(12):1103-1110. Kamali A, Aein A, Naderi N, Choi SJ, Doyle N, Butler IJ, Huisman TAGM, Bonfante EE, Sheikh-Bahaei N, Khanpara S, Patel RP, Riascos RF, Zhang X, Tang RA, Radmanesh A. PMID: 34747259.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury. Geroscience. 2022 02; 44(1):83-102. Robles DJ, Dharani A, Rostowsky KA, Chaudhari NN, Ngo V, Zhang F, O'Donnell LJ, Green L, Sheikh-Bahaei N, Chui HC, Irimia A. PMID: 34704219; PMCID: PMC8811069.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    12. Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists. Alzheimers Dement. 2022 03; 18(3):478-497. Yassine HN, Solomon V, Thakral A, Sheikh-Bahaei N, Chui HC, Braskie MN, Schneider LS, Talbot K. PMID: 34647685; PMCID: PMC8940606.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    13. Cerebral Amyloid Angiopathy-related Inflammation Presenting With a Cystic Lesion in Young-onset Alzheimer Disease. Alzheimer Dis Assoc Disord. 2021 Jul-Sep 01; 35(3):265-268. Ringman JM, Joe E, Sheikh-Bahaei N, Miller C, Vinters HV, Guzman S, Chui HC. PMID: 33480610; PMCID: PMC8289923.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease. Mov Disord. 2021 05; 36(5):1126-1136. Donahue EK, Murdos A, Jakowec MW, Sheikh-Bahaei N, Toga AW, Petzinger GM, Sepehrband F. PMID: 33470460; PMCID: PMC8127386.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    15. Volumetric distribution of perivascular space in relation to mild cognitive impairment. Neurobiol Aging. 2021 03; 99:28-43. Sepehrband F, Barisano G, Sheikh-Bahaei N, Choupan J, Cabeen RP, Lynch KM, Crawford MS, Lan H, Mack WJ, Chui HC, Ringman JM, Toga AW, Alzheimer’s Disease Neuroimaging Initiative. PMID: 33422892; PMCID: PMC7902350.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    16. Body mass index, time of day and genetics affect perivascular spaces in the white matter. J Cereb Blood Flow Metab. 2021 07; 41(7):1563-1578. Barisano G, Sheikh-Bahaei N, Law M, Toga AW, Sepehrband F. PMID: 33183133; PMCID: PMC8221772.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    17. Body mass index, time of day, and genetics affect perivascular spaces in the white matter. BioRxiv. 2020. Giuseppe Barisano, Farshid Sepehrband, Nasim Sheikh-Bahaei, Meng Law, Arthur W. Toga.
    18. Posterior Reversible Encephalopathy Syndrome (PRES): Pathophysiology and Neuro-Imaging. Frontier in Neurology. 2020; 11:463. Redmond-Craig Anderson, Vishal Patel, Nasim Sheikh-Bahaei, Chia Shang J. Liu, Anandh G. Rajamohan, Mark S. Shiroishi, Paul E. Kim, John L. Go, Alexander Lerner, Jay Acharya.
    19. Posterior Reversible Encephalopathy Syndrome (PRES): Pathophysiology and Neuro-Imaging. Front Neurol. 2020; 11:463. Anderson RC, Patel V, Sheikh-Bahaei N, Liu CSJ, Rajamohan AG, Shiroishi MS, Kim PE, Go JL, Lerner A, Acharya J. PMID: 32612567; PMCID: PMC7308488.
      View in: PubMed   Mentions: 30  
    20. Common Data Elements in Head and Neck Radiology Reporting. Neuroimaging Clin N Am. 2020 Aug; 30(3):379-391. Rajamohan AG, Patel V, Sheikh-Bahaei N, Liu CJ, Go JL, Kim PE, Gibbs W, Acharya J. PMID: 32600638.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. MR spectroscopy in Alzheimer’s disease. Biomedical Spectroscopy and Imaging. 2020; 9:13-21. Sheikh-Bahaei N. View Publication.
    22. Advanced Imaging Techniques in Diagnosis of Posterior Reversible Encephalopathy Syndrome (PRES). Front Neurol. 2020; 11:165. Sheikh-Bahaei N, Acharya J, Rajamohan A, Kim PE. PMID: 32218764; PMCID: PMC7078242.
      View in: PubMed   Mentions: 10  
    23. Alteration of perivascular spaces in early cognitive decline. biorxiv. 2020. Farshid Sepehrband, Giuseppe Barisano, Nasim Sheikh-Bahaei, Jeiran Choupan, Ryan P Cabeen , Malcolm S Crawford, Wendy J Mack, Helena C Chui, John M Ringman, Arthur W Toga.
    24. Image processing approaches to enhance perivascular space visibility and quantification using MRI. Sci Rep. 2019 08 26; 9(1):12351. Sepehrband F, Barisano G, Sheikh-Bahaei N, Cabeen RP, Choupan J, Law M, Toga AW. PMID: 31451792; PMCID: PMC6710285.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    25. Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2019 Dec; 11:348-354. Sepehrband F, Cabeen RP, Barisano G, Sheikh-Bahaei N, Choupan J, Law M, Toga AW. PMID: 31049392; PMCID: PMC6479267.
      View in: PubMed   Mentions: 10  
    26. Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer's Disease. J Alzheimers Dis. 2019; 68(4):1489-1497. Sheikh-Bahaei N, Manavaki R, Sajjadi SA, Priest AN, O'Brien JT, Gillard JH. PMID: 30909210.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Positron emission tomography-guided magnetic resonance spectroscopy in Alzheimer disease. Ann Neurol. 2018 04; 83(4):771-778. Sheikh-Bahaei N, Sajjadi SA, Manavaki R, McLean M, O'Brien JT, Gillard JH. PMID: 29518282.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    28. Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease. Alzheimers Dement. 2018 02; 14(2):253-258. Stefaniak JD, Su L, Mak E, Sheikh-Bahaei N, Wells K, Ritchie K, Waldman A, Ritchie CW, O'Brien JT. PMID: 29156222.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    29. Current Role for Biomarkers in Clinical Diagnosis of Alzheimer Disease and Frontotemporal Dementia. Curr Treat Options Neurol. 2017 Nov 14; 19(12):46. Sheikh-Bahaei N, Sajjadi SA, Pierce AL. PMID: 29134465.
      View in: PubMed   Mentions: 7  
    30. Imaging Biomarkers in Alzheimer's Disease: A Practical Guide for Clinicians. J Alzheimers Dis Rep. 2017 Jul 19; 1(1):71-88. Sheikh-Bahaei N, Sajjadi SA, Manavaki R, Gillard JH. PMID: 30480230; PMCID: PMC6159632.
      View in: PubMed   Mentions: 9  
    31. Can MRI Visual Assessment Differentiate the Variants of Primary-Progressive Aphasia? AJNR Am J Neuroradiol. 2017 May; 38(5):954-960. Sajjadi SA, Sheikh-Bahaei N, Cross J, Gillard JH, Scoffings D, Nestor PJ. PMID: 28341715; PMCID: PMC7960364.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    32. In: Saba L., Raz E. eds. Neurovascular Imaging, from basic to advanced concepts,. Anatomy of the neck artery. 2016; 1-9. Sheikh-Bahaei N., Matyz T., Gillard J.
    33. An audit of CT colonography-compliance with NICE guidelines. Clinical Radiology. 2016; 71(S1):15. Khwaja SA., Dambha F., Sheikh-Bahaei N., Pym A., Whitley S.
    34. How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study. IEEE Trans Biomed Eng. 2014 Jan; 61(1):35-40. Sadat U, Mercer JR, Bahaei NS, Thomas OM, Gillard JH. PMID: 23912462.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    35. Intraplaque stretch in carotid atherosclerotic plaque--an effective biomechanical predictor for subsequent cerebrovascular ischemic events. PLoS One. 2013; 8(4):e61522. Teng Z, Sadat U, Wang W, Bahaei NS, Chen S, Young VE, Graves MJ, Gillard JH. PMID: 23626694; PMCID: PMC3634006.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. In Adam A., Dixon A., Gillard J.H., Schaefer-Prokop C.M. eds. Grainger & Allison’s Diagnostic Radiology. Postoperative Spine. 2013; 1364-1373. Matyz T., Sheikh-Bahaei N., Gillard J.
    37. Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage. Atherosclerosis. 2012 Aug; 223(2):321-6. Teng Z, He J, Degnan AJ, Chen S, Sadat U, Bahaei NS, Rudd JH, Gillard JH. PMID: 22762729; PMCID: PMC3437553.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    38. JAMA. Review of MRI Atlas of human White matter. 2012; 308(21):2280-2281. Thomas O.M., Sheikh-Bahaei N.
    39. Physics MCQs for the part 1 FRCR. 2011. Ilyas S., Matys T., Sheikh-Bahaei N., Yamamoto A., Graves M.
    40. The relation between intracranial and intraocular pressures: study of 50 patients. Ann Neurol. 2006 May; 59(5):867-70. Sajjadi SA, Harirchian MH, Sheikhbahaei N, Mohebbi MR, Malekmadani MH, Saberi H. PMID: 16634008.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    41. Photodynamic therapy of head and neck basal cell carcinoma according to different clinicopathologic features. Lasers Surg Med. 2005 Jun; 36(5):377-82. Kaviani A, Ataie-Fashtami L, Fateh M, Sheikhbahaee N, Ghodsi M, Zand N, Djavid GE. PMID: 15965991.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
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