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    William Mack, MD

    TitleAssociate Professor of Neurological Surgery (Clinical Scholar)
    SchoolKeck School of Medicine of USC
    DepartmentNeurological Surgery
    AddressGNH 3300
    Health Sciences Campus
    Los Angeles California 90089-9197
    Phone+1 323 442 7512
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      Other Positions
      TitleDirector, Neurointerventional Program, Keck Hospital of Usc

      TitleDirector, Neurosurgery Ambulatory Services, Keck Medical Center of Usc


      Collapse Overview 
      Collapse Overview
      Dr. Mack's major areas of clinical interest are stroke, brain aneurysms, subarachnoid hemorrhage, arteriovenous malformations (AVMs), arteriovenous fistulas, cavernous malformations, carotid artery disease, intracranial stenosis, and brain tumors. Dr. Mack performs both open surgery and minimally invasive, endovascular procedures for cerebrovascular disorders.

      Dr. Mack is a faculty member of the Neuroscience Graduate Program and is the Principal Investigator and Director of the Cerebrovascular Laboratory in the Zilkha Neurogenetic Institute. He receives NIH R01 funding for his laboratory research. Dr. Mack’s scientific interests are focused on translational efforts to treat ischemic and hemorrhagic stroke. Laboratory investigations concentrate on the pathophysiology of cerebral ischemia and inflammatory modulation. Using the information and experience gained in the laboratory, Dr. Mack is working to develop new technologies, techniques, and therapies to directly improve the clinical care administered to stroke patients.

      William Mack, MD, received his Bachelor degree with honors from Cornell University. He then attended Columbia University, College of Physicians and Surgeons, where he graduated from medical school (Alpha Omega Alpha) and completed Neurosurgical residency training. During residency, he spent one year performing a post-doctoral cerebrovascular research fellowship under Drs. David J. Pinsky and E. Sander Connolly Jr. at Columbia University. Following residency, Dr. Mack completed an Interventional Neuroradiology/ Neuroendovascular Surgery fellowship at UCLA.

      Dr. Mack is board certified by the American Board of Neurological Surgery (FAANS) and is a fellow of the American Heart Association (FAHA) and. He is a committee member on the executive council of the Congress of Neurological Surgeons/ American Association of Neurological Surgeons’ Cerebrovascular Section. Dr. Mack serves as an Associate Editor of the Journal of Neurointerventional Surgery and on the editorial board of World Neurosurgery.


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      Collapse Clinical Trials

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Ho L, Kramer DR, Wen T, Moalem AS, Millett D, Heck CN, Mack W, Liu CY. Potentially preventable complications in epilepsy admissions: The "weekend effect". Epilepsy Behav. 2017 Apr 11; 70(Pt A):50-56. PMID: 28410465.
        View in: PubMed
      2. Mack W, Kim LJ, Lopes DK, Mocco J. Introduction: New techniques and technologies in the management of ischemic stroke. Neurosurg Focus. 2017 Apr; 42(4):E1. PMID: 28366068.
        View in: PubMed
      3. Fargen KM, Soriano-Baron HE, Rushing JT, Mack W, Mocco J, Albuquerque F, Ducruet AF, Mokin M, Linfante I, Wolfe SQ, Wilson JA, Hirsch JA. A survey of intracranial aneurysm treatment practices among United States physicians. J Neurointerv Surg. 2017 Feb 09. PMID: 28184003.
        View in: PubMed
      4. Buchanan IA, Mack W. Minimally Invasive Surgical Approaches for Chronic Subdural Hematomas. Neurosurg Clin N Am. 2017 Apr; 28(2):219-227. PMID: 28325456.
        View in: PubMed
      5. Nyquist P, Jichici D, Bautista C, Burns J, Chhangani S, DeFilippis M, Goldenberg FD, Kim K, Liu-DeRyke X, Mack W, Meyer K. Prophylaxis of Venous Thrombosis in Neurocritical Care Patients: An Executive Summary of Evidence-Based Guidelines: A Statement for Healthcare Professionals From the Neurocritical Care Society and Society of Critical Care Medicine. Crit Care Med. 2017 Jan 12. PMID: 28085682.
        View in: PubMed
      6. Poblete R, Zheng L, Raghavan R, Cen S, Amar A, Sanossian N, Mack W, Kim-Tenser M. Trends in Ventriculostomy-associated Infections and Mortality in Aneurysmal Subarachnoid Hemorrhage: Data from the Nationwide Inpatient Sample. World Neurosurg. 2016 Dec 26. PMID: 28034809.
        View in: PubMed
      7. Bakhsheshian J, Jin DL, Chang KE, Strickland BA, Donoho DA, Cen S, Mack W, Attenello F, Christian EA, Zada G. Risk factors associated with the surgical management of craniopharyngiomas in pediatric patients: analysis of 1961 patients from a national registry database. Neurosurg Focus. 2016 Dec; 41(6):E8. PMID: 27903117.
        View in: PubMed
      8. Dueck HR, Ai R, Camarena A, Ding B, Dominguez R, Evgrafov OV, Fan JB, Fisher SA, Herstein JS, Kim TK, Kim JM, Lin MY, Liu R, Mack W, McGroty S, Nguyen JD, Salathia N, Shallcross J, Souaiaia T, Spaethling JM, Walker CP, Wang J, Wang K, Wang W, Wildberg A, Zheng L, Chow RH, Eberwine J, Knowles JA, Zhang K, Kim J. Assessing characteristics of RNA amplification methods for single cell RNA sequencing. BMC Genomics. 2016 Nov 24; 17(1):966. PMID: 27881084.
        View in: PubMed
      9. Attenello FJ, Mack W. Pitfalls of administrative database analysis are evident when assessing the 'weekend effect' in stroke. Evid Based Med. 2016 Nov 4. PMID: 27815303.
        View in: PubMed
      10. Mack W. Supplementing mechanical thrombectomy with neuroprotection. J Neurointerv Surg. 2016 Nov; 8(11):1095-1096. PMID: 27738203.
        View in: PubMed
      11. Pride GL, Fraser JF, Gupta R, Alberts MJ, Rutledge JN, Fowler R, Ansari SA, Abruzzo T, Albani B, Arthur A, Baxter B, Bulsara KR, Chen M, Delgado Almandoz JE, Gandhi CD, Heck D, Hetts SW, Hirsch JA, Hussain MS, Klucznik R, Lee SK, Mack W, Leslie-Mazwi T, McTaggart RA, Meyers PM, Mocco J, Prestigiacomo C, Patsalides A, Rasmussen P, Starke RM, Sunenshine P, Frei D, Jayaraman MV. Prehospital care delivery and triage of stroke with emergent large vessel occlusion (ELVO): report of the Standards and Guidelines Committee of the Society of Neurointerventional Surgery. J Neurointerv Surg. 2016 Oct 5. PMID: 27707873.
        View in: PubMed
      12. Ramirez L, Kim-Tenser MA, Sanossian N, Cen S, Wen G, He S, Mack W, Towfighi A. Trends in Transient Ischemic Attack Hospitalizations in the United States. J Am Heart Assoc. 2016 Sep 24; 5(9). PMID: 27664805.
        View in: PubMed
      13. James RF, Kramer DR, Aljuboori ZS, Parikh G, Adams SW, Eaton JC, Al-Shaar HA, Badjatia N, Mack W, Simard JM. Novel Treatments in Neuroprotection for Aneurysmal Subarachnoid Hemorrhage. Curr Treat Options Neurol. 2016 Aug; 18(8):38. PMID: 27325362.
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      14. Attenello FJ, Tuchman A, Christian EA, Wen T, Chang KE, Nallapa S, Cen SY, Mack W, Krieger MD, McComb JG. Infection rate correlated with time to repair of open neural tube defects (myelomeningoceles): an institutional and national study. Childs Nerv Syst. 2016 Sep; 32(9):1675-81. PMID: 27444296.
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      15. Ramirez L, Kim-Tenser MA, Sanossian N, Cen S, Wen G, He S, Mack W, Towfighi A. Trends in Acute Ischemic Stroke Hospitalizations in the United States. J Am Heart Assoc. 2016; 5(5). PMID: 27169548.
        View in: PubMed
      16. Liu Q, Babadjouni R, Radwanski R, Cheng H, Patel A, Hodis DM, He S, Baumbacher P, Russin JJ, Morgan TE, Sioutas C, Finch CE, Mack W. Stroke Damage Is Exacerbated by Nano-Size Particulate Matter in a Mouse Model. PLoS One. 2016; 11(4):e0153376. PMID: 27071057.
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      17. Fan TK, Gundimeda U, Mack W, Gopalakrishna R. Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products. Neural Regen Res. 2016 Apr; 11(4):545-6. PMID: 27212904.
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      18. James RF, Kramer DR, Page PS, Gaughen JR, Martin LB, Mack W. Strategic and Technical Considerations for the Endovascular Embolization of Intracranial Meningiomas. Neurosurg Clin N Am. 2016 Apr; 27(2):155-66. PMID: 27012380.
        View in: PubMed
      19. Nyquist P, Bautista C, Jichici D, Burns J, Chhangani S, DeFilippis M, Goldenberg FD, Kim K, Liu-DeRyke X, Mack W, Meyer K. Prophylaxis of Venous Thrombosis in Neurocritical Care Patients: An Evidence-Based Guideline: A Statement for Healthcare Professionals from the Neurocritical Care Society. Neurocrit Care. 2016 Feb; 24(1):47-60. PMID: 26646118.
        View in: PubMed
      20. Mascitelli JR, Wilson N, Shoirah H, De Leacy RA, Furtado SV, Paramasivam S, Oermann EK, Mack W, Tuhrim S, Dangayach NS, Meyer SA, Bederson JB, Mocco J, Fifi JT. The impact of evidence: evolving therapy for acute ischemic stroke in a large healthcare system. J Neurointerv Surg. 2016 Nov; 8(11):1129-1135. PMID: 26747878.
        View in: PubMed
      21. Jin DL, Christian EA, Attenello F, Melamed E, Cen S, Krieger MD, McComb JG, Mack W. Cross-Sectional Analysis on Racial and Economic Disparities Affecting Mortality in Preterm Infants with Posthemorrhagic Hydrocephalus. World Neurosurg. 2016 Apr; 88:399-410. PMID: 26732967.
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      22. Christian EA, Jin DL, Attenello F, Wen T, Cen S, Mack W, Krieger MD, McComb JG. Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000-2010. J Neurosurg Pediatr. 2016 Mar; 17(3):260-9. PMID: 26544084.
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      23. Attenello FJ, Christian E, Wen T, Cen S, Zada G, Kiehna EN, Krieger MD, McComb JG, Mack W. Reevaluating the weekend effect on patients with hydrocephalus undergoing operative shunt intervention. J Neurosurg Pediatr. 2015 Nov 06; 1-7. PMID: 26544080.
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      24. Dimitrov N, Koenig W, Bosson N, Song S, Saver JL, Mack W, Sanossian N. Variability in Criteria for Emergency Medical Services Routing of Acute Stroke Patients to Designated Stroke Center Hospitals. West J Emerg Med. 2015 Sep; 16(5):743-6. PMID: 26587100.
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      25. Mack W. Casting a wide net: the unique diversity of neuroendovascular surgery. J Neurointerv Surg. 2015 Aug; 7(8):549-50. PMID: 26175427.
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      26. Fiorella D, Mocco J, Arthur AS, Lavine S, Albuquerque FC, Frei D, Turner RD, Turk A, Siddiqui AH, Mack W, Alexandrov A, Hirsch JA, Tarr RW. Too much guidance. J Neurointerv Surg. 2015 Sep; 7(9):626-7. PMID: 26206804.
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      27. Kramer DR, Mack W. The Structural and Genetic Variations in Intracerebral Vasculature. World Neurosurg. 2015 Nov; 84(5):1196-7. PMID: 26164194.
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      28. Attenello FJ, Wen T, Huang C, Cen S, Mack W, Acosta FL. Evaluation of weekend admission on the prevalence of hospital acquired conditions in patients receiving thoracolumbar fusions. J Clin Neurosci. 2015 Aug; 22(8):1349-54. PMID: 26055958.
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      29. Russin JJ, Kramer DR, Thomas D, Hasson D, Liu CY, Amar AP, Mack W, Giannotta SL. The importance of preoperative diagnosis of blister aneurysms. J Clin Neurosci. 2015 Sep; 22(9):1408-12. PMID: 25960141.
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      30. Attenello FJ, Wen T, Cen SY, Ng A, Kim-Tenser M, Sanossian N, Amar AP, Mack W. Incidence of "never events" among weekend admissions versus weekday admissions to US hospitals: national analysis. BMJ. 2015; 350:h1460. PMID: 25876878.
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      31. Mack W. Stent retrievers and acute stroke treatment: a rapid learning curve for experienced neurointerventional surgeons. J Neurointerv Surg. 2017 Feb; 9(2):113-114. PMID: 25872518.
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      32. Wen T, Attenello FJ, Wu B, Ng A, Cen SY, Mack W. The july effect: An analysis of never events in the nationwide inpatient sample. J Hosp Med. 2015 Jul; 10(7):432-8. PMID: 25828426.
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      33. Attenello FJ, Ng A, Wen T, Cen SY, Sanossian N, Amar AP, Zada G, Krieger MD, McComb JG, Mack W. Racial and socioeconomic disparities in outcomes following pediatric cerebrospinal fluid shunt procedures. J Neurosurg Pediatr. 2015 Jun; 15(6):560-6. PMID: 25791773.
        View in: PubMed
      34. Attenello FJ, Reid P, Wen T, Cen S, Kim-Tenser M, Sanossian N, Russin J, Amar A, Giannotta S, Mack W, Tenser M. Evaluation of time to aneurysm treatment following subarachnoid hemorrhage: comparison of patients treated with clipping versus coiling. J Neurointerv Surg. 2015 Mar 12. PMID: 25765950.
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      35. Fiorella DJ, Fargen KM, Mocco J, Albuquerque F, Hirsch JA, Chen M, Gupta R, Linfante I, Mack W, Rai A, Tarr RW. Thrombectomy for acute ischemic stroke: an evidence-based treatment. J Neurointerv Surg. 2015 May; 7(5):314-5. PMID: 25735851.
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      36. Wen T, Pease M, Attenello FJ, Tuchman A, Donoho D, Cen S, Mack W, Acosta FL. Evaluation of Effect of Weekend Admission on the Prevalence of Hospital-Acquired Conditions in Patients Receiving Cervical Fusions. World Neurosurg. 2015 Jul; 84(1):58-68. PMID: 25731795.
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      37. Attenello FJ, Mack W. Going Big to Explore the Detail. World Neurosurg. 2015 Jun; 83(6):1041-3. PMID: 25725164.
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      38. Wilson D, Jin DL, Wen T, Carmichael JD, Cen S, Mack W, Zada G. Demographic factors, outcomes, and patient access to transsphenoidal surgery for Cushing's disease: analysis of the Nationwide Inpatient Sample from 2002 to 2010. Neurosurg Focus. 2015 Feb; 38(2):E2. PMID: 25639320.
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      39. Tuchman A, Mehta VA, Mack W, Acosta FL. Novel application of pre-operative vertebral body embolization to reduce intraoperative blood loss during a three-column spinal osteotomy for non-oncologic spinal deformity. J Clin Neurosci. 2015 Apr; 22(4):765-7. PMID: 25564274.
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      40. Mocco J, Fiorella D, Fargen KM, Albuquerque F, Chen M, Gupta R, Hirsch JA, Linfante I, Mack W, Rai AT, Tarr RW. Endovascular therapy for acute ischemic stroke is indicated and evidence based: a position statement. J Neurointerv Surg. 2015 Feb; 7(2):79-81. PMID: 25523788.
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      41. Gupta R, Rai AT, Hirsch JA, Linfante I, Mack W, Mocco J, Albuquerque F, Chen M, Fiorella D, Tarr RW. A research roadmap of future endovascular stroke trials. J Neurointerv Surg. 2015 Feb; 7(2):82-3. PMID: 25523787.
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      42. McDonald CM, Cen S, Ramirez L, Song S, Saver JL, Mack W, Sanossian N. Hospital and demographic characteristics associated with advanced primary stroke center designation. Stroke. 2014 Dec; 45(12):3717-9. PMID: 25388418.
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      43. Chang JJ, Emanuel BA, Mack W, Tsivgoulis G, Alexandrov AV. Matrix metalloproteinase-9: dual role and temporal profile in intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2014 Nov-Dec; 23(10):2498-505. PMID: 25306400.
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      44. Mack W. On keeping of our heritage: family trees, mentorship and the West Coast offense. J Neurointerv Surg. 2014 Oct; 6(8):565-6. PMID: 25194003.
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      45. Attenello FJ, Wang K, Wen T, Cen SY, Kim-Tenser M, Amar AP, Sanossian N, Giannotta SL, Mack W. Health disparities in time to aneurysm clipping/coiling among aneurysmal subarachnoid hemorrhage patients: a national study. World Neurosurg. 2014 Dec; 82(6):1071-6. PMID: 25175276.
        View in: PubMed
      46. Gandhi CD, Bulsara KR, Fifi J, Kass-Hout T, Grant RA, Delgado Almandoz JE, English J, Meyers PM, Abruzzo T, Prestigiacomo CJ, Powers CJ, Lee SK, Albani B, Do HM, Eskey CJ, Patsalides A, Hetts S, Hussain MS, Ansari SA, Hirsch JA, Kelly M, Rasmussen P, Mack W, Pride GL, Alexander MJ, Jayaraman MV. Platelet function inhibitors and platelet function testing in neurointerventional procedures. J Neurointerv Surg. 2014 Oct; 6(8):567-77. PMID: 25056369.
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      47. Lee B, Mehta VA, Amar AP, Tenser MS, Mack W. Transarterial embolization of an anterior fossa cranial base dural arteriovenous fistula. Neurosurg Focus. 2014 Jul; 37(1 Suppl):1. PMID: 24983725.
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      48. Lee B, Mehta VA, Mack W, Tenser MS, Amar AP. Balloon-assisted transarterial embolization of type 1 spinal dural arteriovenous fistula. Neurosurg Focus. 2014 Jul; 37(1 Suppl):1. PMID: 24983724.
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      49. Hanks N, Wen G, He S, Song S, Saver JL, Cen S, Kim-Tenser M, Mack W, Sanossian N. Expansion of u.s. Emergency medical service routing for stroke care: 2000-2010. West J Emerg Med. 2014 Jul; 15(4):499-503. PMID: 25035758.
        View in: PubMed
      50. Wen T, Attenello FJ, He S, Cen Y, Kim-Tenser MA, Sanossian N, Amar AP, Mack W. Racial and socioeconomic disparities in incidence of hospital-acquired complications following cerebrovascular procedures. Neurosurgery. 2014 Jul; 75(1):43-50. PMID: 24662507.
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      51. Wen T, He S, Attenello F, Cen SY, Kim-Tenser M, Adamczyk P, Amar AP, Sanossian N, Mack W. The impact of patient age and comorbidities on the occurrence of "never events" in cerebrovascular surgery: an analysis of the Nationwide Inpatient Sample. J Neurosurg. 2014 Sep; 121(3):580-6. PMID: 24972123.
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      52. Chang JJ, Mack W, Saver JL, Sanossian N. Magnesium: potential roles in neurovascular disease. Front Neurol. 2014; 5:52. PMID: 24782823.
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      53. Tenser MS, Mack W. Plaque morphology and embolic protection strategies in carotid artery stenting. World Neurosurg. 2014 Jul-Aug; 82(1-2):e179-81. PMID: 24549014.
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      54. Lucas J, Mack W. Effects of ionizing radiation on cerebral vasculature. World Neurosurg. 2014 Mar-Apr; 81(3-4):490-1. PMID: 24444794.
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      55. Fargen KM, Blackburn S, Deshaies EM, Carpenter JS, Jabbour P, Mack W, Rai AT, Siddiqui AH, Turner RD, Mocco J. Final results of the multicenter, prospective Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm Study (AMERICA). J Neurointerv Surg. 2015 Jan; 7(1):40-3. PMID: 24394153.
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      56. Liu Q, He S, Groysman L, Shaked D, Russin J, Cen S, Mack W. White matter injury due to experimental chronic cerebral hypoperfusion is associated with c5 deposition. PLoS One. 2013; 8(12):e84802. PMID: 24386419.
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      57. Pease M, Ling C, Mack W, Wang K, Zada G. The role of epigenetic modification in tumorigenesis and progression of pituitary adenomas: a systematic review of the literature. PLoS One. 2013; 8(12):e82619. PMID: 24367530.
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      58. Chang X, Shi L, Gao F, Russin J, Zeng L, He S, Chen TC, Giannotta SL, Weisenberger DJ, Zada G, Wang K, Mack W. Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas. Neurosurg Focus. 2013 Dec; 35(6):E3. PMID: 24289128.
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      59. Zada G, Yashar P, Robison A, Winer J, Khalessi A, Mack W, Giannotta SL. A proposed grading system for standardizing tumor consistency of intracranial meningiomas. Neurosurg Focus. 2013 Dec; 35(6):E1. PMID: 24289117.
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      60. He S, Pham MH, Pease M, Zada G, Giannotta SL, Wang K, Mack W. A review of epigenetic and gene expression alterations associated with intracranial meningiomas. Neurosurg Focus. 2013 Dec; 35(6):E5. PMID: 24289130.
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      61. Chandra RV, Meyers PM, Hirsch JA, Abruzzo T, Eskey CJ, Hussain MS, Lee SK, Narayanan S, Bulsara KR, Gandhi CD, Do HM, Prestigiacomo CJ, Albuquerque FC, Frei D, Kelly ME, Mack W, Pride GL, Jayaraman MV. Vertebral augmentation: report of the Standards and Guidelines Committee of the Society of NeuroInterventional Surgery. J Neurointerv Surg. 2014 Jan; 6(1):7-15. PMID: 24198272.
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      62. Schuberg S, Song S, Saver JL, Mack W, Cen SY, Sanossian N. Impact of emergency medical services stroke routing protocols on primary stroke center certification in california. Stroke. 2013 Dec; 44(12):3584-6. PMID: 24105701.
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      63. Gao F, Lin E, Feng Y, Mack W, Shen Y, Wang K. Characterizing immunoglobulin repertoire from whole blood by a personal genome sequencer. PLoS One. 2013; 8(9):e75294. PMID: 24058670.
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      64. Mehta V, Mack W. Balloon test occlusion in the setting of vessel sacrifice: procedural refinements and adjunct assessment measures. World Neurosurg. 2015 Jan; 83(1):7-8. PMID: 24036338.
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      65. Fargen KM, Blackburn S, Carpenter JS, Jabbour P, Mack W, Rai AT, Siddiqui AH, Turner RD, Mocco J. Early results of the Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm (AMERICA) study: a multicenter prospective observational registry. J Neurointerv Surg. 2014 Sep; 6(7):495-9. PMID: 24026950.
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      66. He S, Russin JJ, Adamczyk P, Giannotta SL, Amar AP, Mack W. A persistent primitive hypoglossal artery arising from the external carotid artery associated with subarachnoid hemorrhage. World Neurosurg. 2014 Jul-Aug; 82(1-2):239.e1-3. PMID: 23851212.
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      67. Kramer DR, Winer JL, Pease BA, Amar AP, Mack W. Cerebral vasospasm in traumatic brain injury. Neurol Res Int. 2013; 2013:415813. PMID: 23862062.
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      68. Attenello FJ, Adamczyk P, Wen G, He S, Zhang K, Russin JJ, Sanossian N, Amar AP, Mack W. Racial and socioeconomic disparities in access to mechanical revascularization procedures for acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Feb; 23(2):327-34. PMID: 23680690.
        View in: PubMed
      69. Belur PK, Chang JJ, He S, Emanuel BA, Mack W. Emerging experimental therapies for intracerebral hemorrhage: targeting mechanisms of secondary brain injury. Neurosurg Focus. 2013 May; 34(5):E9. PMID: 23634928.
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      70. Adamczyk P, He S, Amar AP, Mack W. Medical Management of Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage: A Review of Current and Emerging Therapeutic Interventions. Neurol Res Int. 2013; 2013:462491. PMID: 23691312.
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      71. Mehta V, Russin J, Spirtos A, He S, Adamczyk P, Amar AP, Mack W. Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage. Neurol Res Int. 2013; 2013:943761. PMID: 23691315.
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      72. Arshi B, Mack W, Emanuel B. Invasive and noninvasive multimodal bedside monitoring in subarachnoid hemorrhage: a review of techniques and available data. Neurol Res Int. 2013; 2013:987934. PMID: 23606963.
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      73. Kim-Tenser M, Mack W. Anticoagulation in the setting of intracerebral hemorrhage: controversies in resuming therapy. World Neurosurg. 2014 May-Jun; 81(5-6):669-70. PMID: 23500337.
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      74. He S, Mack W. Considering radiation exposure during diagnostic and therapeutic procedures for arteriovenous malformations in the setting of pregnancy. World Neurosurg. 2014 Jan; 81(1):22-4. PMID: 23416771.
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      75. Adamczyk P, Mack W. The artery of percheron and etiologies of bilateral thalamic stroke. World Neurosurg. 2014 Jan; 81(1):80-2. PMID: 23416778.
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      76. Mills JN, Mehta V, Russin J, Amar AP, Rajamohan A, Mack W. Advanced imaging modalities in the detection of cerebral vasospasm. Neurol Res Int. 2013; 2013:415960. PMID: 23476766.
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      77. Gao F, Shi L, Russin J, Zeng L, Chang X, He S, Chen TC, Giannotta SL, Weisenberger DJ, Zada G, Mack W, Wang K. DNA methylation in the malignant transformation of meningiomas. PLoS One. 2013; 8(1):e54114. PMID: 23349797.
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      78. He S, Mack W. Health-related quality of life after aneurysmal subarachnoid hemorrhage: interplay between physical, cognitive, and emotional factors. World Neurosurg. 2014 Jan; 81(1):37-9. PMID: 23333474.
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      79. Sanossian N, Djabiras C, Mack W, Ovbiagele B. Trends in cancer diagnoses among inpatients hospitalized with stroke. J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):1146-50. PMID: 23246193.
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      80. Russin JJ, Mack W, Carey JN, Minneti M, Giannotta SL. Simulation of a high-flow extracranial-intracranial bypass using a radial artery graft in a novel fresh tissue model. Neurosurgery. 2012 Dec; 71(2 Suppl Operative):ons315-19; discussion ons 319-20. PMID: 22791034.
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      81. Adamczyk P, Attenello F, Wen G, He S, Russin J, Sanossian N, Amar AP, Mack W. Mechanical thrombectomy in acute stroke: utilization variances and impact of procedural volume on inpatient mortality. J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1263-9. PMID: 23017430.
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      82. Khaldi A, Fargen KM, Waldau B, Siddiqui AH, Hoh BL, Mack W, Carpenter J, Veznedaroglu E, Mocco J. The Orbit Galaxy XTRASOFT Coils: A Multicenter Study of Coil Safety and Efficacy in Both Ruptured and Unruptured Cerebral Aneurysms. J Vasc Interv Neurol. 2012 Jun; 5(1):17-21. PMID: 22737261.
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      83. Adamczyk P, Amar AP, Mack W, Larsen DW. Recurrence of "cured" dural arteriovenous fistulas after Onyx embolization. Neurosurg Focus. 2012 May; 32(5):E12. PMID: 22537121.
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      84. Tenser MS, Amar AP, Mack W. Mechanical Thrombectomy for Acute Ischemic Stroke Using the MERCI Retriever and Penumbra Aspiration Systems. World Neurosurg. 2011 Dec; 76(6 Suppl):S16-23. PMID: 22182267.
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      85. Ducruet AF, Sosunov SA, Visovatti SH, Petrovic-Djergovic D, Mack W, Connolly ES, Pinsky DJ. Paradoxical exacerbation of neuronal injury in reperfused stroke despite improved blood flow and reduced inflammation in early growth response-1 gene-deleted mice. Neurol Res. 2011 Sep; 33(7):717-25. PMID: 21756551.
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      86. Mack W. Re: Evidence-based treatment of carotid stenosis: is the evidence strong enough? Neurosurg Focus. 2011 Jun; 30(6):E3. PMID: 21631227.
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      87. Groysman LI, Emanuel BA, Kim-Tenser MA, Sung GY, Mack W. Therapeutic hypothermia in acute ischemic stroke. Neurosurg Focus. 2011 Jun; 30(6):E17. PMID: 21631218.
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      88. Ducruet AF, Mack W, Mocco J, Hoh DJ, Coon AL, D'Ambrosio AL, Winfree CJ, Pinsky DJ, Connolly ES. Preclinical evaluation of postischemic dehydroascorbic Acid administration in a large-animal stroke model. Transl Stroke Res. 2011 Sep; 2(3):399-403. PMID: 24323656.
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      89. Pham MH, Zada G, Mosich GM, Chen TC, Giannotta SL, Wang K, Mack W. Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms. Neurosurg Focus. 2011 May; 30(5):E7. PMID: 21529178.
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      90. Mack W, Gonzalez NR, Jahan R, Vinuela F. Endovascular management of anterior cranial fossa dural arteriovenous malformations. A technical report and anatomical discussion. Interv Neuroradiol. 2011 Mar; 17(1):93-103. PMID: 21561565.
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      91. Komotar RJ, Starke RM, Arias EJ, Garrett MC, Otten ML, Merkow MB, Hassid B, Mocco J, Sughrue ME, Kim GH, Mack W, Ducruet AF, Connolly ES. The complement cascade: new avenues in stroke therapy. Curr Vasc Pharmacol. 2009 Jul; 7(3):287-92. PMID: 19601853.
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      92. Mack W, Kellner CP, Sahlein DH, Ducruet AF, Kim GH, Mocco J, Zurica J, Komotar RJ, Haque R, Sciacca R, Quest DO, Solomon RA, Connolly ES, Heyer EJ. Intraoperative magnesium infusion during carotid endarterectomy: a double-blind placebo-controlled trial. J Neurosurg. 2009 May; 110(5):961-7. PMID: 19199498.
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      93. Syed ON, Hankinson TC, Mack W, Feldstein NA, Anderson RC. Radiolucent hair accessories causing depressed skull fracture following blunt cranial trauma. J Neurosurg Pediatr. 2008 Dec; 2(6):424-6. PMID: 19035690.
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      94. Mack W, Ducruet AF, Hickman ZL, Kalyvas JT, Cleveland JR, Mocco J, Schmidt M, Mayer SA, Connolly ES. Doppler ultrasonography screening of poor-grade subarachnoid hemorrhage patients increases the diagnosis of deep venous thrombosis. Neurol Res. 2008 Nov; 30(9):889-92. PMID: 18973729.
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      95. Kim GH, Mocco J, Hahn DK, Kellner CP, Komotar RJ, Ducruet AF, Mack W, Connolly ES. Protective effect of C5a receptor inhibition after murine reperfused stroke. Neurosurgery. 2008 Jul; 63(1):122-5; discussion 125-6. PMID: 18728577.
        View in: PubMed
      96. Kim GH, Hahn DK, Kellner CP, Hickman ZL, Komotar RJ, Starke RM, Mack W, Mocco J, Solomon RA, Connolly ES. Plasma levels of vascular endothelial growth factor after treatment for cerebral arteriovenous malformations. Stroke. 2008 Aug; 39(8):2274-9. PMID: 18535271.
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      97. Mack W, Ducruet AF, Angevine PD, Komotar RJ, Shrebnick DB, Edwards NM, Smith CR, Heyer EJ, Monyero L, Connolly ES, Solomon RA. Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned. Neurosurgery. 2008 Jun; 62(6 Suppl 3):1311-23. PMID: 18695551.
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      98. Ducruet AF, Hassid BG, Mack W, Sosunov SA, Otten ML, Fusco DJ, Hickman ZL, Kim GH, Komotar RJ, Mocco J, Connolly ES. C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent. J Cereb Blood Flow Metab. 2008 May; 28(5):1048-58. PMID: 18197178.
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      99. Komotar RJ, Kim GH, Otten ML, Hassid B, Mocco J, Sughrue ME, Starke RM, Mack W, Ducruet AF, Merkow MB, Garrett MC, Connolly ES. The role of complement in stroke therapy. Adv Exp Med Biol. 2008; 632:23-33. PMID: 19025111.
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      100. Mack W, Hickman ZL, Ducruet AF, Kalyvas JT, Garrett MC, Starke RM, Komotar RJ, Lavine SD, Meyers PM, Mayer SA, Connolly ES. Pupillary reactivity upon hospital admission predicts long-term outcome in poor grade aneurysmal subarachnoid hemorrhage patients. Neurocrit Care. 2008; 8(3):374-9. PMID: 18058256.
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      101. Ducruet AF, Mocco J, Mack W, Coon AL, Marsh HC, Pinsky DJ, Hickman ZL, Kim GH, Connolly ES. Pre-clinical evaluation of an sLe x-glycosylated complement inhibitory protein in a non-human primate model of reperfused stroke. J Med Primatol. 2007 Dec; 36(6):375-80. PMID: 17976043.
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      102. Mack W, Ghatan S. Congenital pterional dermal sinus in an 18-month-old child: case report. Neurosurgery. 2007 Sep; 61(3):E661; discussion E661. PMID: 17881944.
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      103. Mack W, Ducruet AF, Hickman ZL, Garrett MC, Albert EJ, Kellner CP, Mocco J, Connolly ES. Early plasma complement C3a levels correlate with functional outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2007 Aug; 61(2):255-60; discussion 260-1. PMID: 17762737.
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      104. Mack W, Ducruet AF, Angevine PD, Komotar RJ, Shrebnick DB, Edwards NM, Smith CR, Heyer EJ, Monyero L, Connolly ES, Solomon RA. Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned. Neurosurgery. 2007 May; 60(5):815-27; discussion 815-27. PMID: 17460516.
        View in: PubMed
      105. Komotar RJ, Connolly ES, Lignelli AA, Mack W, Mocco J, Harbaugh RE. Clinicoradiological review: bilateral ethmoidal artery dural arteriovenous fistulas. Neurosurgery. 2007 Jan; 60(1):131-5; discussion 135-6. PMID: 17228261.
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      106. Mocco J, Tomey MI, Komotar RJ, Mack W, Frucht SJ, Goodman RR, McKhann GM. Ventriculoperitoneal shunting of idiopathic normal pressure hydrocephalus increases midbrain size: a potential mechanism for gait improvement. Neurosurgery. 2006 Oct; 59(4):847-50; discussion 850-1. PMID: 17038948.
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      107. Mocco J, Mack W, Ducruet AF, King RG, Sughrue ME, Coon AL, Sosunov SA, Sciacca RR, Zhang Y, Marsh HC, Pinsky DJ, Connolly ES. Preclinical evaluation of the neuroprotective effect of soluble complement receptor type 1 in a nonhuman primate model of reperfused stroke. J Neurosurg. 2006 Oct; 105(4):595-601. PMID: 17044564.
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      108. Mack W, Hickman ZL, Connolly ES, Angevine PD. Is Screening for Deep Venous Thrombosis in Aneurysmal Subarachnoid Hemorrhage Patients Cost Effective? 855. Neurosurgery. 2006 Aug 01; 59(2):472. PMID: 28180737.
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      109. Mack W, Mocco J, Ducruet AF, Laufer I, King RG, Zhang Y, Guo W, Pinsky DJ, Connolly ES. A cerebroprotective dose of intravenous citrate/sorbitol-stabilized dehydroascorbic acid is correlated with increased cerebral ascorbic acid and inhibited lipid peroxidation after murine reperfused stroke. Neurosurgery. 2006 Aug; 59(2):383-8; discussion 383-8. PMID: 16883179.
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      110. Mocco J, Mack W, Ducruet AF, Sosunov SA, Sughrue ME, Hassid BG, Nair MN, Laufer I, Komotar RJ, Claire M, Holland H, Pinsky DJ, Connolly ES. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res. 2006 Jul 21; 99(2):209-17. PMID: 16778128.
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      111. Mocco J, Wilson DA, Komotar RJ, Zurica J, Mack W, Halazun HJ, Hatami R, Sciacca RR, Connolly ES, Heyer EJ. Predictors of neurocognitive decline after carotid endarterectomy. Neurosurgery. 2006 May; 58(5):844-50; discussion 844-50. PMID: 16639318.
        View in: PubMed
      112. Mack W, Sughrue ME, Ducruet AF, Mocco J, Sosunov SA, Hassid BG, Silverberg JZ, Ten VS, Pinsky DJ, Connolly ES. Temporal pattern of C1q deposition after transient focal cerebral ischemia. J Neurosci Res. 2006 Apr; 83(5):883-9. PMID: 16447284.
        View in: PubMed
      113. Mocco J, Ransom ER, Komotar RJ, Mack W, Sergot PB, Albert SM, Connolly ES. Racial differences in cerebral vasospasm: a systematic review of the literature. Neurosurgery. 2006 Feb; 58(2):305-14. PMID: 16462484.
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      114. Mocco J, Wilson DA, Komotar RJ, Tomey ML, Ducruet AF, Mack W, Zurica J, Sciacca RR, Connolly ES, Heyer EJ. Galbraith Award: evaluation of risk factors associated with neurocognitive changes after carotid endarterectomy. Clin Neurosurg. 2006; 53:301-6. PMID: 17380766.
        View in: PubMed
      115. Mocco J, Wilson DA, Ducruet AF, Komotar RJ, Mack W, Zurica J, Sciacca RR, Heyer EJ, Connolly ES. Elevations in preoperative monocyte count predispose to acute neurocognitive decline after carotid endarterectomy for asymptomatic carotid artery stenosis. Stroke. 2006 Jan; 37(1):240-2. PMID: 16322501.
        View in: PubMed
      116. Komotar RJ, Mocco J, Mack W, Ransom ER, Zacharia BE, King RG, Ducruet AF, Cohen HG, Arango V, Connolly ES. Co-registration of radiographic and pathologic infarct territory in a non-human primate model of stroke. Neurol Res. 2005 Sep; 27(6):634-7. PMID: 16157015.
        View in: PubMed
      117. Komotar RJ, Mocco J, Ransom ER, Mack W, Zacharia BE, Wilson DA, Naidech AM, McKhann GM, Mayer SA, Fitzsimmons BM, Connolly ES. Herniation Secondary to Critical Postcraniotomy Cerebrospinal Fluid Hypovolemia. Neurosurgery. 2005 Aug 01; 57(2):286-292. PMID: 28184747.
        View in: PubMed
      118. Mocco J, Mack W, Wilson DA, Komotar RJ, Zurica J, Halazun HJ, Hatami R, Sergot PB, Connolly ES, Heyer EJ. 867 Predictors of Neurocognitive Dysfunction after Carotid Endarterectomy. Neurosurgery. 2005 Aug 01; 57(2):419. PMID: 28184764.
        View in: PubMed
      119. Komotar RJ, Mocco J, Ransom ER, Mack W, Zacharia BE, Wilson DA, Naidech AM, McKhann GM, Mayer SA, Fitzsimmons BF, Connolly ES. Herniation secondary to critical postcraniotomy cerebrospinal fluid hypovolemia. Neurosurgery. 2005 Aug; 57(2):286-92; discussion 286-92. PMID: 16094157.
        View in: PubMed
      120. Anderson RC, Connolly ES, Komotar RJ, Mack W, McKhann GM, Van Orman CB, Hedlund G, Proctor KA, Townsend JJ, Walker ML. Clinicopathological review: tumefactive demyelination in a 12-year-old girl. Neurosurgery. 2005 May; 56(5):1051-7; discussion 1051-7. PMID: 15854254.
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      121. Parra A, Kreiter KT, Williams S, Sciacca R, Mack W, Naidech AM, Commichau CS, Fitzsimmons BF, Janjua N, Mayer SA, Connolly ES. Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study. Neurosurgery. 2005 Mar; 56(3):476-84; discussion 476-84. PMID: 15730572.
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      122. Parra A, Kreiter KT, Williams S, Sciacca R, Mack W, Naidech AM, Commichau CS, Fitzsimmons BM, Janjua N, Mayer SA, Connolly ES. Effect of Prior Statin Use on Functional Outcome and Delayed Vasospasm after Acute Aneurysmal Subarachnoid Hemorrhage: A Matched Controlled Cohort Study. Neurosurgery. 2005 Mar 01; 56(3):476-484. PMID: 28184638.
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      123. Mocco J, Laufer I, Mack W, Winfree CJ, Libien J, Connolly ES. An extramedullary foramen magnum cavernous malformation presenting with acute subarachnoid hemorrhage: case report and literature review. Neurosurgery. 2005 Feb; 56(2):E410; discussion E410. PMID: 15729780.
        View in: PubMed
      124. Winfree CJ, Mack W, Sisti MB. Solitary cerebellar metastasis of malignant pleural mesothelioma: case report. Surg Neurol. 2004 Feb; 61(2):174-8; discussion 178-9. PMID: 14751636.
        View in: PubMed
      125. D'Ambrosio AL, Sughrue ME, Mocco J, Mack W, King RG, Agarwal S, Connolly ES. A modified transorbital baboon model of reperfused stroke. Methods Enzymol. 2004; 386:60-73. PMID: 15120246.
        View in: PubMed
      126. Mack W, Komotar RJ, Mocco J, Coon AL, Hoh DJ, King RG, Ducruet AF, Ransom ER, Oppermann M, DeLaPaz R, Connolly ES. Serial magnetic resonance imaging in experimental primate stroke: validation of MRI for pre-clinical cerebroprotective trials. Neurol Res. 2003 Dec; 25(8):846-52. PMID: 14669528.
        View in: PubMed
      127. Mack W, Huang J, Winfree C, Kim G, Oppermann M, Dobak J, Inderbitzen B, Yon S, Popilskis S, Lasheras J, Sciacca RR, Pinsky DJ, Connolly ES. Ultrarapid, convection-enhanced intravascular hypothermia: a feasibility study in nonhuman primate stroke. Stroke. 2003 Aug; 34(8):1994-9. PMID: 12829868.
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      128. Mack W, King RG, Ducruet AF, Kreiter K, Mocco J, Maghoub A, Mayer S, Connolly ES. Intracranial pressure following aneurysmal subarachnoid hemorrhage: monitoring practices and outcome data. Neurosurg Focus. 2003 Apr 15; 14(4):e3. PMID: 15679302.
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      129. Mack W, King RG, Hoh DJ, Coon AL, Ducruet AF, Huang J, Mocco J, Winfree CJ, D'Ambrosio AL, Nair MN, Sciacca RR, Connolly ES. An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia. Neurol Res. 2003 Apr; 25(3):280-4. PMID: 12739238.
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      130. Mocco J, Choudhri T, Huang J, Harfeldt E, Efros L, Klingbeil C, Vexler V, Hall W, Zhang Y, Mack W, Popilskis S, Pinsky DJ, Connolly ES. HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke. Circ Res. 2002 Nov 15; 91(10):907-14. PMID: 12433835.
        View in: PubMed
      131. Ivanova S, Batliwalla F, Mocco J, Kiss S, Huang J, Mack W, Coon A, Eaton JW, Al-Abed Y, Gregersen PK, Shohami E, Connolly ES, Tracey KJ. Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5579-84. PMID: 11943872.
        View in: PubMed
      132. Heyer EJ, Sharma R, Rampersad A, Winfree CJ, Mack W, Solomon RA, Todd GJ, McCormick PC, McMurtry JG, Quest DO, Stern Y, Lazar RM, Connolly ES. A controlled prospective study of neuropsychological dysfunction following carotid endarterectomy. Arch Neurol. 2002 Feb; 59(2):217-22. PMID: 11843692.
        View in: PubMed
      133. Mack W, Mocco J, Hoh DJ, Huang J, Choudhri TF, Kreiter KT, Lozier A, Opperman M, Poisik A, Yorgason J, Solomon RA, Mayer SA, Connolly ES. Outcome prediction with serum intercellular adhesion molecule-1 levels after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2002 Jan; 96(1):71-5. PMID: 11794607.
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