Ruslan Rust

Title(s)Assistant Professor of Research Physiology and Neuroscience
SchoolKeck School of Medicine of Usc
Address1501 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0003-3376-3453 Additional info
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    Swiss Federal Institute of Technology, Zurich, SwitzerlandPhD08/2019Neuroscience and Vascular Biology

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    Ruslan Rust, PhD, holds the position of Assistant Professor of Research in Physiology and Neuroscience within the group led by Berislav Zlokovic, MD, PhD, at the Keck School of Medicine of USC.

    A central focus of the team is to overcome existing limitations in cell therapies for brain injuries by utilizing advanced genetic, molecular, and computational tools. Recently, they have developed scalable sources of cells, including pericytes and neural stem cells, harvested from induced pluripotent stem cells (iPSCs) under xeno-free conditions. These cells are equipped with fluorescent and bioluminescent reporters, allowing for continuous monitoring post-transplantation.

    In the next phase, the cells will be genetically engineered with a brain-shuttle system to enhance their distribution throughout the brain. To prevent immune rejection, the transplants will be designed to co-express specific immunosuppressive molecules, coupled with safety checkpoints. The effectiveness of these optimized cell therapies will be assessed through a comprehensive experimental pipeline, encompassing in vivo imaging, deep learning-based behavioral profiling, and single-cell omics technologies. The insights gained from this research are anticipated to be instrumental in advancing cell therapy for brain injuries closer to clinical applications in the near future.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Science around the world. Trends Mol Med. 2024 Feb 23. Burton JP, Kofoed RH, Rust R. PMID: 38402077.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Dataset on stroke infarct volume in rodents: A comparison of MRI and histological methods. Data Brief. 2024 Apr; 53:110188. Weber RZ, Bernardoni D, Rentsch NH, Buil BA, Halliday S, Augath MA, Razansky D, Tackenberg C, Rust R. PMID: 38406243; PMCID: PMC10885712.
      View in: PubMed   Mentions:
    3. Beneath the radar: immune-evasive cell sources for stroke therapy. Trends Mol Med. 2024 Mar; 30(3):223-238. Achón Buil B, Rentsch NH, Weber RZ, Rickenbach C, Halliday SJ, Hotta A, Tackenberg C, Rust R. PMID: 38272713.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. A toolkit for stroke infarct volume estimation in rodents. Neuroimage. 2024 Feb 15; 287:120518. Weber RZ, Bernardoni D, Rentsch NH, Buil BA, Halliday S, Augath MA, Razansky D, Tackenberg C, Rust R. PMID: 38219841.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke. J Neurochem. 2023 12; 167(6):733-752. Hood RJ, Sanchez-Bezanilla S, Beard DJ, Rust R, Turner RJ, Stuckey SM, Collins-Praino LE, Walker FR, Nilsson M, Ong LK. PMID: 38010732.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability. J Cereb Blood Flow Metab. 2023 Nov 24; 271678X231216270. Rust R, Holm MM, Egger M, Weinmann O, van Rossum D, Walter FR, Santa-Maria AR, Grönnert L, Maurer MA, Kraler S, Akhmedov A, Cideciyan R, Lüscher TF, Deli MA, Herrmann IK, Schwab ME. PMID: 38000040.
      View in: PubMed   Mentions: 1     Fields:    
    7. Ischemic stroke-related gene expression profiles across species: a meta-analysis. J Inflamm (Lond). 2023 Jun 19; 20(1):21. Rust R. PMID: 37337154; PMCID: PMC10280959.
      View in: PubMed   Mentions: 2  
    8. Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging. Cell Metab. 2023 Jun 06; 35(6):1085. Leiter O, Zhuo Z, Rust R, Wasielewska JM, Grönnert L, Kowal S, Overall RW, Adusumilli VS, Blackmore DG, Southon A, Ganio K, McDevitt CA, Rund N, Brici D, Mudiyan IA, Sykes AM, Rünker AE, Zocher S, Ayton S, Bush AI, Bartlett PF, Hou ST, Kempermann G, Walker TL. PMID: 37285804.
      View in: PubMed   Mentions:    Fields:    
    9. Rebooting disruptive science: Exploring the challenges and potential solutions. Eur J Clin Invest. 2023 Aug; 53(8):e13988. Rust R. PMID: 36965020.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions. Angiogenesis. 2023 08; 26(3):385-407. Fan Z, Ardicoglu R, Batavia AA, Rust R, von Ziegler L, Waag R, Zhang J, Desgeorges T, Sturman O, Dang H, Weber R, Roszkowski M, Moor AE, Schwab ME, Germain PL, Bohacek J, De Bock K. PMID: 36933174; PMCID: PMC10328887.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. Editing a gateway for cell therapy across the blood-brain barrier. Brain. 2023 03 01; 146(3):823-841. Achón Buil B, Tackenberg C, Rust R. PMID: 36397727; PMCID: PMC9976985.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    12. Molecular and anatomical roadmap of stroke pathology in immunodeficient mice. Front Immunol. 2022; 13:1080482. Weber RZ, Mulders G, Perron P, Tackenberg C, Rust R. PMID: 36569903; PMCID: PMC9785704.
      View in: PubMed   Mentions: 2     Fields:    
    13. Stimulation of the cuneiform nucleus enables training and boosts recovery after spinal cord injury. Brain. 2022 10 21; 145(10):3681-3697. Hofer AS, Scheuber MI, Sartori AM, Good N, Stalder SA, Hammer N, Fricke K, Schalbetter SM, Engmann AK, Weber RZ, Rust R, Schneider MP, Russi N, Favre G, Schwab ME. PMID: 35583160; PMCID: PMC9586551.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    14. Deep learning-based behavioral profiling of rodent stroke recovery. BMC Biol. 2022 10 15; 20(1):232. Weber RZ, Mulders G, Kaiser J, Tackenberg C, Rust R. PMID: 36243716; PMCID: PMC9571460.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    15. Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications. J Transl Med. 2022 09 16; 20(1):421. Rust R, Weber RZ, Generali M, Kehl D, Bodenmann C, Uhr D, Wanner D, Zürcher KJ, Saito H, Hoerstrup SP, Nitsch RM, Tackenberg C. PMID: 36114512; PMCID: PMC9482172.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    16. Preserving stroke penumbra by targeting lipid signalling. J Cereb Blood Flow Metab. 2023 01; 43(1):167-169. Achón Buil B, Rust R. PMID: 35999812; PMCID: PMC9875356.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    17. Stem Cell Therapy for Repair of the Injured Brain: Five Principles. Neuroscientist. 2024 Feb; 30(1):10-16. Rust R, Tackenberg C. PMID: 35968796; PMCID: PMC10822053.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes. Stem Cell Reports. 2022 May 10; 17(5):1229-1231. de Leeuw SM, Kirschner AWT, Lindner K, Rust R, Budny V, Wolski WE, Gavin AC, Nitsch RM, Tackenberg C. PMID: 35545024; PMCID: PMC9133647.
      View in: PubMed   Mentions: 3     Fields:    
    19. Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging. Cell Metab. 2022 03 01; 34(3):408-423.e8. Leiter O, Zhuo Z, Rust R, Wasielewska JM, Grönnert L, Kowal S, Overall RW, Adusumilli VS, Blackmore DG, Southon A, Ganio K, McDevitt CA, Rund N, Brici D, Mudiyan IA, Sykes AM, Rünker AE, Zocher S, Ayton S, Bush AI, Bartlett PF, Hou ST, Kempermann G, Walker TL. PMID: 35120590.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    20. Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain. J Vis Exp. 2022 01 27; (179). Weber RZ, Bodenmann C, Uhr D, Zürcher KJ, Wanner D, Generali M, Nitsch RM, Rust R, Tackenberg C. PMID: 35156654.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    21. Isolation and Culture of Adult Hippocampal Precursor Cells as Free-Floating Neurospheres. Methods Mol Biol. 2022; 2389:33-44. Rust R, Walker TL. PMID: 34557999.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes. Stem Cell Reports. 2022 01 11; 17(1):110-126. de Leeuw SM, Kirschner AWT, Lindner K, Rust R, Budny V, Wolski WE, Gavin AC, Nitsch RM, Tackenberg C. PMID: 34919811; PMCID: PMC8758949.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    23. Slow development of bladder malfunction parallels spinal cord fiber sprouting and interneurons' loss after spinal cord transection. Exp Neurol. 2022 02; 348:113937. Sartori AM, Hofer AS, Scheuber MI, Rust R, Kessler TM, Schwab ME. PMID: 34826427.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. 'Scary' pericytes: the fibrotic scar in brain and spinal cord lesions. Trends Neurosci. 2022 01; 45(1):6-7. Rentsch NH, Rust R. PMID: 34774344.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Astrocytes for brain repair: More than just a neuron's sidekick. Brain Pathol. 2021 09; 31(5):e12999. Weber RZ, Perron P, Rust R. PMID: 34196052; PMCID: PMC8412072.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    26. iPS-derived pericytes for neurovascular regeneration. Eur J Clin Invest. 2021 09; 51(9):e13601. Kirabali T, Rust R. PMID: 34050924; PMCID: PMC8459220.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    27. Towards blood biomarkers for stroke patients. J Cereb Blood Flow Metab. 2021 04; 41(4):914-916. Rust R. PMID: 33563080; PMCID: PMC7983325.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Characterization of the Blood Brain Barrier Disruption in the Photothrombotic Stroke Model. Front Physiol. 2020; 11:586226. Weber RZ, Grönnert L, Mulders G, Maurer MA, Tackenberg C, Schwab ME, Rust R. PMID: 33262704; PMCID: PMC7688466.
      View in: PubMed   Mentions: 13  
    29. Author Correction: Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions. Sci Rep. 2020 Nov 09; 10(1):19816. Wasielewska JM, Grönnert L, Rund N, Donix L, Rust R, Sykes AM, Hoppe A, Roers A, Kempermann G, Walker TL. PMID: 33168937; PMCID: PMC7653037.
      View in: PubMed   Mentions:    Fields:    
    30. Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease. Brain Pathol. 2020 11; 30(6):1056-1070. Kirabali T, Rust R, Rigotti S, Siccoli A, Nitsch RM, Kulic L. PMID: 32866303; PMCID: PMC8018068.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    31. A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain. Front Neurosci. 2020; 14:244. Rust R, Kirabali T, Grönnert L, Dogancay B, Limasale YDP, Meinhardt A, Werner C, Laviña B, Kulic L, Nitsch RM, Tackenberg C, Schwab ME. PMID: 32265643; PMCID: PMC7099171.
      View in: PubMed   Mentions: 16  
    32. Insights into the dual role of angiogenesis following stroke. J Cereb Blood Flow Metab. 2020 06; 40(6):1167-1171. Rust R. PMID: 32065073; PMCID: PMC7238380.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    33. Anti-Nogo-A antibodies prevent vascular leakage and act as pro-angiogenic factors following stroke. Sci Rep. 2019 12 27; 9(1):20040. Rust R, Weber RZ, Grönnert L, Mulders G, Maurer MA, Hofer AS, Sartori AM, Schwab ME. PMID: 31882970; PMCID: PMC6934709.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    34. Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair. Trends Neurosci. 2019 09; 42(9):644-656. Rust R, Grönnert L, Weber RZ, Mulders G, Schwab ME. PMID: 31285047.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    35. Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14270-14279. Rust R, Grönnert L, Gantner C, Enzler A, Mulders G, Weber RZ, Siewert A, Limasale YDP, Meinhardt A, Maurer MA, Sartori AM, Hofer AS, Werner C, Schwab ME. PMID: 31235580; PMCID: PMC6628809.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    36. A Revised View on Growth and Remodeling in the Retinal Vasculature. Sci Rep. 2019 03 01; 9(1):3263. Rust R, Grönnert L, Dogançay B, Schwab ME. PMID: 30824785; PMCID: PMC6397250.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    37. T Lymphocytes Contribute to the Control of Baseline Neural Precursor Cell Proliferation but Not the Exercise-Induced Up-Regulation of Adult Hippocampal Neurogenesis. Front Immunol. 2018; 9:2856. Walker TL, Schallenberg S, Rund N, Grönnert L, Rust R, Kretschmer K, Kempermann G. PMID: 30619254; PMCID: PMC6297802.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. Inflammation after Stroke: A Local Rather Than Systemic Response? Trends Neurosci. 2018 12; 41(12):877-879. Rust R, Grönnert L, Schwab ME. PMID: 30327142.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    39. Pro- and antiangiogenic therapies: current status and clinical implications. FASEB J. 2019 01; 33(1):34-48. Rust R, Gantner C, Schwab ME. PMID: 30085886.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    40. Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits. PLoS One. 2018; 13(7):e0200896. Berry S, Weinmann O, Fritz AK, Rust R, Wolfer D, Schwab ME, Gerber U, Ster J. PMID: 30040841; PMCID: PMC6057643.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    41. Stroke Promotes Systemic Endothelial Inflammation and Atherosclerosis. Trends Mol Med. 2018 07; 24(7):593-595. Rust R, Hofer AS, Schwab ME. PMID: 29747910.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    42. Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions. Sci Rep. 2017 12 19; 7(1):17859. Wasielewska JM, Grönnert L, Rund N, Donix L, Rust R, Sykes AM, Hoppe A, Roers A, Kempermann G, Walker TL. PMID: 29259265; PMCID: PMC5736663.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    43. Insights into the Dual Role of Inflammation after Spinal Cord Injury. J Neurosci. 2017 05 03; 37(18):4658-4660. Rust R, Kaiser J. PMID: 28469010; PMCID: PMC6596496.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
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