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Thomas D Coates, MD

TitleProfessor of Pediatrics
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHL Mail Stop 54
Off Campus
Los Angeles CA 90089
Phone+1 323 361 2352
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    Other Positions
    TitleSection Head of Hematology

    TitleDirector of Sickle/Hemoglobinopathy Program


    Collapse Overview 
    Collapse Overview
    I primarily work in two areas of basic and translational research: 1) the role of inflammation in the genesis of vascular disease in sickle cell disease; 2) the detection and management of transfusion related iron overload. Our research employs various engineering-intensive methodologies (MRI, laser Doppler flow, digital image analysis, signal processing) to explore the basic mechanisms of sickle cell disease and to measure the effect of various treatment modalities. We use direct measures of microvascular blood flow to monitor the process of vasoocclusion and relate it to simultaneous measures of autonomic nervous system function. These methodologies translate in measurements that can be used to follow patients clinically. In collaboration with members of the Cardiology, Pulmonology, and Radiology Departments at Children’s Hospital Los Angeles, the Departments of Biomedical Engineering and Physiology/Biophysics at the Keck School of Medicine, we devised methods to measure the sickling process in human sickle cell subjects and relate these measurements to clinical factors that modulate disease severity.


    Collapse Research 
    Collapse Research Activities and Funding
    Multimodal biophysical markers of vascular disease in hemoglobinopathies
    NIH/NHLBI U01HL117718Aug 15, 2013 - May 31, 2018
    Role: Principal Investigator
    SOUTHERN CALIFORNIA BLOOD SAFETY SURVEILLANCE PROGRAM IN HEMATOLOGICAL DISORFERS
    CDC/NCBDD U50DD000874May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Basic and Translational Research Program
    NIH/NHLBI U54HL090511Jun 15, 2008 - Feb 28, 2013
    Role: Principal Investigator
    Research Initiatives for the Preventions of Complications of Thalassemia
    CDC/NCBDD U01DD000309Sep 30, 2007 - Sep 29, 2012
    Role: Principal Investigator
    Human models of sickle cell vascular damage
    NIH/NHLBI R01HL071801Jul 8, 2003 - Jun 30, 2008
    Role: Principal Investigator
    GRANULES AND ORGANELLES AND LEUKOCYTE ACTIVATION
    NIH/NIAID R01AI023547Sep 1, 1985 - Nov 30, 1999
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Coates TD, Cazzola M. Introduction to a review series on iron metabolism and its disorders. Blood. 2018 Nov 14. PMID: 30429162.
      View in: PubMed
    2. Sunwoo J, Chalacheva P, Khaleel M, Shah P, Sposto R, Kato RM, Detterich J, Zeltzer LK, Wood JC, Coates TD, Khoo MC. A novel cross-correlation methodology for assessing biophysical responses associated with pain. J Pain Res. 2018; 11:2207-2219. PMID: 30323655.
      View in: PubMed
    3. Mainous AG, Carek PJ, Lynch K, Tanner RJ, Hulihan MM, Baskin J, Coates TD. Effectiveness of Clinical Decision Support Based Intervention in the Improvement of Care for Adult Sickle Cell Disease Patients in Primary Care. J Am Board Fam Med. 2018 Sep-Oct; 31(5):812-816. PMID: 30201679.
      View in: PubMed
    4. Coates TD. You don't always get what you want: Does hypoxia cause sickle cell crisis? Am J Hematol. 2018 Aug; 93(4):475-477. PMID: 29377212.
      View in: PubMed
    5. Coates TD, Chalacheva P, Zeltzer L, Khoo MCK. Autonomic nervous system involvement in sickle cell disease. Clin Hemorheol Microcirc. 2018; 68(2-3):251-262. PMID: 29614636.
      View in: PubMed
    6. Bush A, Chai Y, Choi SY, Vaclavu L, Holland S, Nederveen A, Coates T, Wood J. Pseudo continuous arterial spin labeling quantification in anemic subjects with hyperemic cerebral blood flow. Magn Reson Imaging. 2018 Apr; 47:137-146. PMID: 29229306.
      View in: PubMed
    7. Coloigner J, Kim Y, Bush A, Choi S, Balderrama MC, Coates TD, O'Neil SH, Lepore N, Wood JC. Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia. PLoS One. 2017; 12(10):e0184860. PMID: 28981541.
      View in: PubMed
    8. Coloigner J, Phlypo R, Coates TD, Lepore N, Wood JC. Graph Lasso-Based Test for Evaluating Functional Brain Connectivity in Sickle Cell Disease. Brain Connect. 2017 Sep; 7(7):443-453. PMID: 28747064.
      View in: PubMed
    9. Khaleel M, Puliyel M, Shah P, Sunwoo J, Kato RM, Chalacheva P, Thuptimdang W, Detterich J, Wood JC, Tsao J, Zeltzer L, Sposto R, Khoo MCK, Coates TD. Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain. Am J Hematol. 2017 Nov; 92(11):1137-1145. PMID: 28707371.
      View in: PubMed
    10. Bhatt RR, Martin SR, Evans S, Lung K, Coates TD, Zeltzer LK, Tsao JC. The effect of hypnosis on pain and peripheral blood flow in sickle-cell disease: a pilot study. J Pain Res. 2017; 10:1635-1644. PMID: 28769584.
      View in: PubMed
    11. Doyle EK, Toy K, Valdez B, Chia JM, Coates T, Wood JC. Ultra-short echo time images quantify high liver iron. Magn Reson Med. 2018 Mar; 79(3):1579-1585. PMID: 28643355.
      View in: PubMed
    12. Chalacheva P, Khaleel M, Sunwoo J, Shah P, Detterich JA, Kato RM, Thuptimdang W, Meiselman HJ, Sposto R, Tsao J, Wood JC, Zeltzer L, Coates TD, Khoo MCK. Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease. PLoS One. 2017; 12(5):e0178353. PMID: 28542469.
      View in: PubMed
    13. Choi S, Bush AM, Borzage MT, Joshi AA, Mack WJ, Coates TD, Leahy RM, Wood JC. Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients. Neuroimage Clin. 2017; 15:239-246. PMID: 28540180.
      View in: PubMed
    14. Coates TD, Wood JC. How we manage iron overload in sickle cell patients. Br J Haematol. 2017 06; 177(5):703-716. PMID: 28295188.
      View in: PubMed
    15. Paulukonis ST, Feuchtbaum LB, Coates TD, Neumayr LD, Treadwell MJ, Vichinsky EP, Hulihan MM. Emergency department utilization by Californians with sickle cell disease, 2005-2014. Pediatr Blood Cancer. 2017 Jun; 64(6). PMID: 28000344.
      View in: PubMed
    16. Coates TD. Unchanneling cardiac iron in humans. Blood. 2016 09 22; 128(12):1538-40. PMID: 27658696.
      View in: PubMed
    17. Bush A, Borzage M, Detterich J, Kato RM, Meiselman HJ, Coates T, Wood JC. Empirical model of human blood transverse relaxation at 3?T improves MRI T2 oximetry. Magn Reson Med. 2017 Jun; 77(6):2364-2371. PMID: 27385283.
      View in: PubMed
    18. Wang L, Valderramos SG, Wu A, Ouyang S, Li C, Brasil P, Bonaldo M, Coates T, Nielsen-Saines K, Jiang T, Aliyari R, Cheng G. From Mosquitos to Humans: Genetic Evolution of Zika Virus. Cell Host Microbe. 2016 May 11; 19(5):561-5. PMID: 27091703.
      View in: PubMed
    19. Coates TD, Carson S, Wood JC, Berdoukas V. Management of iron overload in hemoglobinopathies: what is the appropriate target iron level? Ann N Y Acad Sci. 2016 03; 1368(1):95-106. PMID: 27186942.
      View in: PubMed
    20. Borzage MT, Bush AM, Choi S, Nederveen AJ, Václavu L, Coates TD, Wood JC. Predictors of cerebral blood flow in patients with and without anemia. J Appl Physiol (1985). 2016 Apr 15; 120(8):976-81. PMID: 26796758; PMCID: PMC4835904 [Available on 04/15/17].
      View in: PubMed, PubMed Central
    21. Reitman AJ, Coates TD, Freyer DR. Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia. Pediatrics. 2015 Sep; 136(3):e697-700. PMID: 26283784.
      View in: PubMed
    22. Berdoukas V, Coates TD, Cabantchik ZI. Iron and oxidative stress in cardiomyopathy in thalassemia. Free Radic Biol Med. 2015 Nov; 88(Pt A):3-9. PMID: 26216855.
      View in: PubMed
    23. Chalacheva P, Kato RM, Sangkatumvong S, Detterich J, Bush A, Wood JC, Meiselman H, Coates TD, Khoo MC. Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis. Physiol Rep. 2015 Jul 14; 3(7). PMID: 26177958; PMCID: PMC4552538.
      View in: PubMed, PubMed Central
    24. Detterich JA, Kato RM, Rabai M, Meiselman HJ, Coates TD, Wood JC. Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. Blood. 2015 Aug 06; 126(6):703-10. PMID: 26036801; PMCID: PMC4528063.
      View in: PubMed, PubMed Central
    25. Huang KE, Mittelman SD, Coates TD, Geffner ME, Wood JC. A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing. J Pediatr Hematol Oncol. 2015 Jan; 37(1):54-9. PMID: 24942024; PMCID: PMC4393555.
      View in: PubMed, PubMed Central
    26. Puliyel M, Mainous AG, Berdoukas V, Coates TD. Iron toxicity and its possible association with treatment of Cancer: lessons from hemoglobinopathies and rare, transfusion-dependent anemias. Free Radic Biol Med. 2015 Feb; 79:343-51. PMID: 25463277.
      View in: PubMed
    27. Paulukonis ST, Harris WT, Coates TD, Neumayr L, Treadwell M, Vichinsky E, Feuchtbaum LB. Population based surveillance in sickle cell disease: methods, findings and implications from the California registry and surveillance system in hemoglobinopathies project (RuSH). Pediatr Blood Cancer. 2014 Dec; 61(12):2271-6. PMID: 25176145.
      View in: PubMed
    28. Mainous AG, Tanner RJ, Hulihan MM, Amaya M, Coates TD. The impact of chelation therapy on survival in transfusional iron overload: a meta-analysis of myelodysplastic syndrome. Br J Haematol. 2014 Dec; 167(5):720-3. PMID: 25048454; PMCID: PMC4991026.
      View in: PubMed, PubMed Central
    29. Young SD, Holloway I, Jaganath D, Rice E, Westmoreland D, Coates T. Project HOPE: online social network changes in an HIV prevention randomized controlled trial for African American and Latino men who have sex with men. Am J Public Health. 2014 Sep; 104(9):1707-12. PMID: 25033137; PMCID: PMC4151951.
      View in: PubMed, PubMed Central
    30. Meloni A, Puliyel M, Pepe A, Berdoukas V, Coates TD, Wood JC. Cardiac iron overload in sickle-cell disease. Am J Hematol. 2014 Jul; 89(7):678-83. PMID: 24664847.
      View in: PubMed
    31. Coates TD. Physiology and pathophysiology of iron in hemoglobin-associated diseases. Free Radic Biol Med. 2014 Jul; 72:23-40. PMID: 24726864; PMCID: PMC4940047.
      View in: PubMed, PubMed Central
    32. Coates TD. Bad liver and a broken heart. Blood. 2014 Mar 06; 123(10):1434-6. PMID: 24627546.
      View in: PubMed
    33. Puliyel M, Sposto R, Berdoukas VA, Hofstra TC, Nord A, Carson S, Wood J, Coates TD. Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload. Am J Hematol. 2014 Apr; 89(4):391-4. PMID: 24347294.
      View in: PubMed
    34. Berdoukas V, Nord A, Carson S, Puliyel M, Hofstra T, Wood J, Coates TD. Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age. Am J Hematol. 2013 Nov; 88(11):E283-5. PMID: 23861216.
      View in: PubMed
    35. Vichinsky E, Neumayr L, Trimble S, Giardina PJ, Cohen AR, Coates T, Boudreaux J, Neufeld EJ, Kenney K, Grant A, Thompson AA. Transfusion complications in thalassemia patients: a report from the Centers for Disease Control and Prevention (CME). Transfusion. 2014 Apr; 54(4):972-81; quiz 971. PMID: 23889533; PMCID: PMC4410835.
      View in: PubMed, PubMed Central
    36. Clark J, Salvatierra J, Segura E, Salazar X, Konda K, Perez-Brumer A, Hall E, Klausner J, Caceres C, Coates T. Moderno love: sexual role-based identities and HIV/STI prevention among men who have sex with men in Lima, Peru. AIDS Behav. 2013 May; 17(4):1313-28. PMID: 22614747; PMCID: PMC3494756.
      View in: PubMed, PubMed Central
    37. Meloni A, Detterich J, Berdoukas V, Pepe A, Lombardi M, Coates TD, Wood JC. Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron. Am J Hematol. 2013 Mar; 88(3):213-8. PMID: 23386313.
      View in: PubMed
    38. Sohn EY, Kato R, Noetzli LJ, Gera A, Coates T, Harmatz P, Keens TG, Wood JC. Exercise performance in thalassemia major: correlation with cardiac iron burden. Am J Hematol. 2013 Mar; 88(3):193-7. PMID: 23339082.
      View in: PubMed
    39. Haines D, Martin M, Carson S, Oliveros O, Green S, Coates T, Eile J, Schilling L, Dinu B, Mendoza T, Gerstenberger E, Trachtenberg F, Vichinsky E. Pain in thalassaemia: the effects of age on pain frequency and severity. Br J Haematol. 2013 Mar; 160(5):680-7. PMID: 23278768.
      View in: PubMed
    40. Detterich JA, Sangkatumvong S, Kato R, Dongelyan A, Bush A, Khoo M, Meiselman HJ, Coates TD, Wood JC. Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion. Transfusion. 2013 May; 53(5):1059-68. PMID: 23176402; PMCID: PMC3957479.
      View in: PubMed, PubMed Central
    41. Detterich J, Alexy T, Rabai M, Wenby R, Dongelyan A, Coates T, Wood J, Meiselman H. Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion. 2013 Feb; 53(2):297-305. PMID: 22882132; PMCID: PMC3510323.
      View in: PubMed, PubMed Central
    42. Noetzli LJ, Panigrahy A, Mittelman SD, Hyderi A, Dongelyan A, Coates TD, Wood JC. Pituitary iron and volume predict hypogonadism in transfusional iron overload. Am J Hematol. 2012 Feb; 87(2):167-71. PMID: 22213195.
      View in: PubMed
    43. Noetzli LJ, Mittelman SD, Watanabe RM, Coates TD, Wood JC. Pancreatic iron and glucose dysregulation in thalassemia major. Am J Hematol. 2012 Feb; 87(2):155-60. PMID: 22120775.
      View in: PubMed
    44. Detterich J, Noetzli L, Dorey F, Bar-Cohen Y, Harmatz P, Coates T, Wood J. Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol. 2012 Feb; 87(2):139-44. PMID: 22052662; PMCID: PMC3306475.
      View in: PubMed, PubMed Central
    45. Sangkatumvong S, Khoo MC, Kato R, Detterich JA, Bush A, Keens TG, Meiselman HJ, Wood JC, Coates TD. Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. PMID: 21616995; PMCID: PMC3175540.
      View in: PubMed, PubMed Central
    46. Sohn EY, Noetzli LJ, Gera A, Kato R, Coates TD, Harmatz P, Keens TG, Wood JC. Pulmonary function in thalassaemia major and its correlation with body iron stores. Br J Haematol. 2011 Oct; 155(1):102-5. PMID: 21810090; PMCID: PMC3169737.
      View in: PubMed, PubMed Central
    47. Young SD, Konda K, Caceres C, Galea J, Sung-Jae L, Salazar X, Coates T. Effect of a community popular opinion leader HIV/STI intervention on stigma in urban, coastal Peru. AIDS Behav. 2011 Jul; 15(5):930-7. PMID: 20953691; PMCID: PMC3110996.
      View in: PubMed, PubMed Central
    48. Coates TD. Is it time to SWiTCH to composite primary endpoints? Pediatr Blood Cancer. 2011 Dec 01; 57(6):906-7. PMID: 21594983.
      View in: PubMed
    49. Wood JC, Mo A, Gera A, Koh M, Coates T, Gilsanz V. Quantitative computed tomography assessment of transfusional iron overload. Br J Haematol. 2011 Jun; 153(6):780-5. PMID: 21517807.
      View in: PubMed
    50. Wood JC, Glynos T, Thompson A, Giardina P, Harmatz P, Kang BP, Paley C, Coates TD. Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial. Haematologica. 2011 Jul; 96(7):1055-8. PMID: 21393329; PMCID: PMC3128226.
      View in: PubMed, PubMed Central
    51. Wolfson JA, Schrager SM, Khanna R, Coates TD, Kipke MD. Sickle cell disease in California: sociodemographic predictors of emergency department utilization. Pediatr Blood Cancer. 2012 Jan; 58(1):66-73. PMID: 21360655; PMCID: PMC3272000.
      View in: PubMed, PubMed Central
    52. Coates TD. So what if blood is thicker than water? Blood. 2011 Jan 20; 117(3):745-6. PMID: 21252094.
      View in: PubMed
    53. Noetzli LJ, Coates TD, Wood JC. Pancreatic iron loading in chronically transfused sickle cell disease is lower than in thalassaemia major. Br J Haematol. 2011 Jan; 152(2):229-33. PMID: 21118197.
      View in: PubMed
    54. Wolfson JA, Schrager SM, Coates TD, Kipke MD. Sickle-cell disease in California: a population-based description of emergency department utilization. Pediatr Blood Cancer. 2011 Mar; 56(3):413-9. PMID: 21225920; PMCID: PMC3286652.
      View in: PubMed, PubMed Central
    55. Parekh C, Hofstra T, Church JA, Coates TD. Hemophagocytic lymphohistiocytosis in children with chronic granulomatous disease. Pediatr Blood Cancer. 2011 Mar; 56(3):460-2. PMID: 21225928.
      View in: PubMed
    56. Wood JC, Glynos T, Thompson A, Giardina P, Harmatz P, Kang BP, Paley C, Coates TD. Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial. Am J Hematol. 2010 Oct; 85(10):818-9. PMID: 20799360.
      View in: PubMed
    57. Wood JC, Noetzl L, Hyderi A, Joukar M, Coates T, Mittelman S. Predicting pituitary iron and endocrine dysfunction. Ann N Y Acad Sci. 2010 Aug; 1202:123-8. PMID: 20712782.
      View in: PubMed
    58. Wood JC, Kang BP, Thompson A, Giardina P, Harmatz P, Glynos T, Paley C, Coates TD. The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores. Blood. 2010 Jul 29; 116(4):537-43. PMID: 20421452.
      View in: PubMed
    59. Sangkatumvong S, Coates TD, Wood JC, Meiselman HJ, Kato R, Detterich JA, Bush A, Khoo MC. Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1626-9. PMID: 21096136.
      View in: PubMed
    60. Noetzli LJ, Papudesi J, Coates TD, Wood JC. Pancreatic iron loading predicts cardiac iron loading in thalassemia major. Blood. 2009 Nov 05; 114(19):4021-6. PMID: 19726718; PMCID: PMC2774543.
      View in: PubMed, PubMed Central
    61. Adamkiewicz TV, Abboud MR, Paley C, Olivieri N, Kirby-Allen M, Vichinsky E, Casella JF, Alvarez OA, Barredo JC, Lee MT, Iyer RV, Kutlar A, McKie KM, McKie V, Odo N, Gee B, Kwiatkowski JL, Woods GM, Coates T, Wang W, Adams RJ. Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury. Blood. 2009 Nov 19; 114(21):4632-8. PMID: 19721013; PMCID: PMC2780299.
      View in: PubMed, PubMed Central
    62. Ghugre NR, Gonzalez-Gomez I, Butensky E, Noetzli L, Fischer R, Williams R, Harmatz P, Coates TD, Wood JC. Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease. Am J Hematol. 2009 Aug; 84(8):480-3. PMID: 19536851; PMCID: PMC2884400.
      View in: PubMed, PubMed Central
    63. Claster S, Wood JC, Noetzli L, Carson SM, Hofstra TC, Khanna R, Coates TD. Nutritional deficiencies in iron overloaded patients with hemoglobinopathies. Am J Hematol. 2009 Jun; 84(6):344-8. PMID: 19415722; PMCID: PMC2887656.
      View in: PubMed, PubMed Central
    64. Brewer CJ, Coates TD, Wood JC. Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major. J Magn Reson Imaging. 2009 Feb; 29(2):357-64. PMID: 19161188; PMCID: PMC2906451.
      View in: PubMed, PubMed Central
    65. Schein A, Enriquez C, Coates TD, Wood JC. Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis. J Magn Reson Imaging. 2008 Sep; 28(3):698-704. PMID: 18777554; PMCID: PMC2597353.
      View in: PubMed, PubMed Central
    66. Noetzli LJ, Carson SM, Nord AS, Coates TD, Wood JC. Longitudinal analysis of heart and liver iron in thalassemia major. Blood. 2008 Oct 01; 112(7):2973-8. PMID: 18650452; PMCID: PMC2556627.
      View in: PubMed, PubMed Central
    67. Wood JC, Origa R, Agus A, Matta G, Coates TD, Galanello R. Onset of cardiac iron loading in pediatric patients with thalassemia major. Haematologica. 2008 Jun; 93(6):917-20. PMID: 18413890; PMCID: PMC2892933.
      View in: PubMed, PubMed Central
    68. Delea TE, Hagiwara M, Thomas SK, Baladi JF, Phatak PD, Coates TD. Outcomes, utilization, and costs among thalassemia and sickle cell disease patients receiving deferoxamine therapy in the United States. Am J Hematol. 2008 Apr; 83(4):263-70. PMID: 17924547.
      View in: PubMed
    69. Fung EB, Harmatz PR, Milet M, Coates TD, Thompson AA, Ranalli M, Mignaca R, Scher C, Giardina P, Robertson S, Neumayr L, Vichinsky EP. Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia. Bone. 2008 Jul; 43(1):162-168. PMID: 18430624; PMCID: PMC2500183.
      View in: PubMed, PubMed Central
    70. Sangkatumvong S, Khoo MC, Coates TD. Abnormal cardiac autonomic control in sickle cell disease following transient hypoxia. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1996-9. PMID: 19163084.
      View in: PubMed
    71. Delea TE, Edelsberg J, Sofrygin O, Thomas SK, Baladi JF, Phatak PD, Coates TD. Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review. Transfusion. 2007 Oct; 47(10):1919-29. PMID: 17880620.
      View in: PubMed
    72. Vichinsky E, Onyekwere O, Porter J, Swerdlow P, Eckman J, Lane P, Files B, Hassell K, Kelly P, Wilson F, Bernaudin F, Forni GL, Okpala I, Ressayre-Djaffer C, Alberti D, Holland J, Marks P, Fung E, Fischer R, Mueller BU, Coates T. A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease. Br J Haematol. 2007 Feb; 136(3):501-8. PMID: 17233848; PMCID: PMC1974786.
      View in: PubMed, PubMed Central
    73. Delea TE, Sofrygin O, Thomas SK, Baladi JF, Phatak PD, Coates TD. Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective. Pharmacoeconomics. 2007; 25(4):329-42. PMID: 17402805.
      View in: PubMed
    74. Sayles JN, Pettifor A, Wong MD, MacPhail C, Lee SJ, Hendriksen E, Rees HV, Coates T. Factors associated with self-efficacy for condom use and sexual negotiation among South african youth. J Acquir Immune Defic Syndr. 2006 Oct 01; 43(2):226-33. PMID: 16951647; PMCID: PMC2819666.
      View in: PubMed, PubMed Central
    75. Ghugre NR, Enriquez CM, Gonzalez I, Nelson MD, Coates TD, Wood JC. MRI detects myocardial iron in the human heart. Magn Reson Med. 2006 Sep; 56(3):681-6. PMID: 16888797; PMCID: PMC2887674.
      View in: PubMed, PubMed Central
    76. Ghugre NR, Enriquez CM, Coates TD, Nelson MD, Wood JC. Improved R2* measurements in myocardial iron overload. J Magn Reson Imaging. 2006 Jan; 23(1):9-16. PMID: 16329085; PMCID: PMC2892961.
      View in: PubMed, PubMed Central
    77. Wu S, Gonzalez-Gomez I, Coates T, Yano S. Cobalamin C disease presenting with hemophagocytic lymphohistiocytosis. Pediatr Hematol Oncol. 2005 Dec; 22(8):717-21. PMID: 16251179.
      View in: PubMed
    78. Singer ST, Kuypers FA, Olivieri NF, Weatherall DJ, Mignacca R, Coates TD, Davies S, Sweeters N, Vichinsky EP. Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome. Br J Haematol. 2005 Nov; 131(3):378-88. PMID: 16225658.
      View in: PubMed
    79. Ghugre NR, Coates TD, Nelson MD, Wood JC. Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med. 2005 Nov; 54(5):1185-93. PMID: 16215963; PMCID: PMC2892963.
      View in: PubMed, PubMed Central
    80. Wood JC, Otto-Duessel M, Aguilar M, Nick H, Nelson MD, Coates TD, Pollack H, Moats R. Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation. 2005 Jul 26; 112(4):535-43. PMID: 16027257; PMCID: PMC2896311.
      View in: PubMed, PubMed Central
    81. Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 2005 Aug 15; 106(4):1460-5. PMID: 15860670; PMCID: PMC1895207.
      View in: PubMed, PubMed Central
    82. Wood JC, Enriquez C, Ghugre N, Otto-Duessel M, Aguilar M, Nelson MD, Moats R, Coates TD. Physiology and pathophysiology of iron cardiomyopathy in thalassemia. Ann N Y Acad Sci. 2005; 1054:386-95. PMID: 16339687; PMCID: PMC2892916.
      View in: PubMed, PubMed Central
    83. Wood JC, Tyszka JM, Carson S, Nelson MD, Coates TD. Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood. 2004 Mar 01; 103(5):1934-6. PMID: 14630822.
      View in: PubMed
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