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David R. Freyer, DO

Title(s)Professor of Clinical Pediatrics
AddressCHL Mail Stop 54
Off Campus
Los Angeles CA 90089
Phone+1 323 361 8953
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    Dr. David Freyer joined Children's Hospital Los Angeles in January 2008. As Director of the LIFE Program, he oversees all aspects of its services, which include clinical assessments of more than 350 patients annually, research regarding their long-term outcomes, and training of fellows, residents, and other health care professionals in the care of childhood cancer survivors. His clinical and research activities have focused principally on cancer survivorship and cancer control, including the recognition, management and prevention of short-and long-term morbidity of treatment, as well as health care transition for young adult survivors of childhood cancer, adolescent and young adult (AYA) oncology, palliative care, and decision-making at the end of life. Dr. Freyer is a member of the Children's Oncology Group where he serves as chair of the AYA Committee, on the Steering Committees for the Survivorship & Outcomes and Cancer Control Committees, and on several protocol and administrative committees. Dr. Freyer graduated magna cum laude from DePauw University, obtained his medical degree from the Des Moines University College of Osteopathic Medicine and Surgery, and completed post-graduate medical training at Chicago College of Osteopathic Medicine and Hospitals, Rush University Medical Center and the University of Michigan Medical Center. In 2007, he obtained a MS degree in Clinical Research Design and Statistical Analysis from the University of Michigan School of Public Health.

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    Project Milestones: Young Adult Cancer Survivorship
    NIH/NCI R01CA237230Jul 1, 2019 - Jun 30, 2024
    Role: Co-Principal Investigator
    CHANGE OF GRANTEE INSTITUTION: Creating and Validating Child Adverse Event Reporting in Oncology Trials
    NIH/NCI R01CA175759Apr 1, 2013 - Mar 31, 2019
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Identifying metrics of success for transitional care practices in childhood cancer survivorship: a qualitative interview study of survivors. BMC Cancer. 2020 Sep 21; 20(1):898. Sadak KT, Gemeda MT, Grafelman M, Neglia JP, Freyer DR, Harwood E, Mikal J. PMID: 32957976.
      View in: PubMed   Mentions:    Fields:    
    2. Assessment of provider perspectives on otoprotection research for children and adolescents: A Children's Oncology Group Cancer Control and Supportive Care Committee survey. Pediatr Blood Cancer. 2020 Sep 04; e28647. Orgel E, Freyer DR, Ullrich NJ, Hardy KK, Thomas SM, Dvorak CC, Esbenshade AJ. PMID: 32886425.
      View in: PubMed   Mentions:    Fields:    
    3. Estimating cancer treatment intensity from SEER cancer registry data: methods and implications for population-based registry studies of pediatric cancers. Cancer Causes Control. 2020 Oct; 31(10):881-890. Tobin JL, Thomas SM, Freyer DR, Hamilton AS, Milam JE. PMID: 32757117.
      View in: PubMed   Mentions:    Fields:    
    4. Effect of a Daily Text Messaging and Directly Supervised Therapy Intervention on Oral Mercaptopurine Adherence in Children With Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA Netw Open. 2020 Aug 03; 3(8):e2014205. Bhatia S, Hageman L, Chen Y, Wong FL, McQuaid EL, Duncan C, Mascarenhas L, Freyer D, Mba N, Aristizabal P, Walterhouse D, Lew G, Kempert PH, Russell TB, McNall-Knapp RY, Jacobs S, Dang H, Raetz E, Relling MV, Landier W. PMID: 32852553.
      View in: PubMed   Mentions:    Fields:    
    5. Profiles of emotional distress and growth among adolescents and young adults with cancer: A longitudinal study. Health Psychol. 2020 May; 39(5):370-380. Chen J, Zebrack B, Embry L, Freyer DR, Aguilar C, Cole S. PMID: 32202826.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. The Children's Oncology Group Adolescent and Young Adult Responsible Investigator Network: A New Model for Addressing Site-Level Factors Impacting Clinical Trial Enrollment. J Adolesc Young Adult Oncol. 2020 08; 9(4):522-527. Roth M, Mittal N, Saha A, Freyer DR. PMID: 32077782.
      View in: PubMed   Mentions:    Fields:    
    7. Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study. Lancet Oncol. 2020 03; 21(3):421-435. Suh E, Stratton KL, Leisenring WM, Nathan PC, Ford JS, Freyer DR, McNeer JL, Stock W, Stovall M, Krull KR, Sklar CA, Neglia JP, Armstrong GT, Oeffinger KC, Robison LL, Henderson TO. PMID: 32066543.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era. Cancer Med. 2020 03; 9(6):2146-2152. Roth ME, Unger JM, O'Mara AM, Lewis MA, Budd T, Johnson RH, Pollock BH, Blanke C, Freyer DR. PMID: 32009305.
      View in: PubMed   Mentions: 1     Fields:    
    9. Validity and Reliability of the Pediatric Patient-Reported Outcomes - Common Terminology Criteria for Adverse Events. J Natl Cancer Inst. 2020 Jan 30. Reeve BB, McFatrich M, Mack JW, Maurer SH, Jacobs SS, Freyer DR, Withycombe JS, Baker JN, Castellino SM, Lin L, Lucas NR, Hinds PS. PMID: 31999349.
      View in: PubMed   Mentions:    Fields:    
    10. Systematic review of barriers and facilitators to clinical trial enrollment among adolescents and young adults with cancer: Identifying opportunities for intervention. Cancer. 2020 03 01; 126(5):949-957. Siembida EJ, Loomans-Kropp HA, Trivedi N, O'Mara A, Sung L, Tami-Maury I, Freyer DR, Roth M. PMID: 31869454.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline. Lancet Child Adolesc Health. 2020 02; 4(2):141-150. Freyer DR, Brock PR, Chang KW, Dupuis LL, Epelman S, Knight K, Mills D, Phillips R, Potter E, Risby D, Simpkin P, Sullivan M, Cabral S, Robinson PD, Sung L. PMID: 31866182.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Mapping child and adolescent self-reported symptom data to clinician-reported adverse event grading to improve pediatric oncology care and research. Cancer. 2020 01 01; 126(1):140-147. McFatrich M, Brondon J, Lucas NR, Hinds PS, Maurer SH, Mack JW, Freyer DR, Jacobs SS, Baker JN, Mowbray C, Wang M, Castellino SM, Barz Leahy A, Reeve BB. PMID: 31553494.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Obesity and Risk for Second Malignant Neoplasms in Childhood Cancer Survivors: A Case-Control Study Utilizing the California Cancer Registry. Cancer Epidemiol Biomarkers Prev. 2019 10; 28(10):1612-1620. Moke DJ, Hamilton AS, Chehab L, Deapen D, Freyer DR. PMID: 31337641.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Evaluating and providing quality health information for adolescents and young adults with cancer. Pediatr Blood Cancer. 2019 10; 66(10):e27931. Grace JG, Schweers L, Anazodo A, Freyer DR. PMID: 31322817.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Emerging Cancer Survival Trends, Disparities, and Priorities in Adolescents and Young Adults: A California Cancer Registry-Based Study. JNCI Cancer Spectr. 2019 Jun; 3(2):pkz031. Moke DJ, Tsai K, Hamilton AS, Hwang A, Liu L, Freyer DR, Deapen D. PMID: 31276099.
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    16. Response to Siegel et al. J Natl Cancer Inst. 2019 06 01; 111(6):635-636. Liu L, Moke DJ, Tsai KY, Hwang A, Freyer DR, Hamilton AS, Zhang J, Cockburn M, Deapen D. PMID: 30793169.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Interventions for cisplatin-induced hearing loss in children and adolescents with cancer. Lancet Child Adolesc Health. 2019 08; 3(8):578-584. Freyer DR, Brock P, Knight K, Reaman G, Cabral S, Robinson PD, Sung L. PMID: 31160205.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Transitional care practices, services, and delivery in childhood cancer survivor programs: A survey study of U.S. survivorship providers. Pediatr Blood Cancer. 2019 08; 66(8):e27793. Sadak KT, Szalda D, Lindgren BR, Kinahan KE, Eshelman-Kent D, Schwartz LA, Henderson T, Freyer DR. PMID: 31099145.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. A Reappraisal of Sex-Specific Cancer Survival Trends Among Adolescents and Young Adults in the United States. J Natl Cancer Inst. 2019 05 01; 111(5):509-518. Liu L, Moke DJ, Tsai KY, Hwang A, Freyer DR, Hamilton AS, Zhang J, Cockburn M, Deapen D. PMID: 30321398.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    20. Understanding, measuring, and addressing the financial impact of cancer on adolescents and young adults. Pediatr Blood Cancer. 2019 07; 66(7):e27660. Salsman JM, Bingen K, Barr RD, Freyer DR. PMID: 30756484.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. A prospective comparison of cancer clinical trial availability and enrollment among adolescents/young adults treated at an adult cancer hospital or affiliated children's hospital. Cancer. 2018 10 15; 124(20):4064-4071. Thomas SM, Malvar J, Tran HH, Shows JT, Freyer DR. PMID: 30291804.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Sodium Thiosulfate and Cisplatin-Induced Hearing Loss. N Engl J Med. 2018 09 20; 379(12):1180-1. Freyer DR, Frazier AL, Sung L. PMID: 30260148.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Treatment of young adults with Philadelphia-negative acute lymphoblastic leukemia and lymphoblastic lymphoma: Hyper-CVAD vs. pediatric-inspired regimens. Am J Hematol. 2018 10; 93(10):1254-1266. Siegel SE, Advani A, Seibel N, Muffly L, Stock W, Luger S, Shah B, DeAngelo DJ, Freyer DR, Douer D, Johnson RH, Hayes-Lattin B, Lewis M, Jaboin JJ, Coccia PF, Bleyer A. PMID: 30058716.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. A comparative analysis of clinicopathological features and survival among early adolescents/young adults and children with low-grade glioma: a report from the Children's Oncology Group. J Neurooncol. 2018 Dec; 140(3):575-582. Margol AS, Yeo KK, Xia C, Onar A, Robison NJ, Freyer DR, Dhall G. PMID: 30173409.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Childhood Cancer Survivorship and Substance Use Behaviors: A Matched Case-Control Study Among Hispanic Adolescents and Young Adults. J Adolesc Health. 2018 07; 63(1):115-117. Milam J, Slaughter R, Tobin JL, Unger JB, Ritt-Olson A, Freyer DR, Soto D, Hamilton AS. PMID: 30060847.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Treatment strategies for adolescent and young adult patients with acute myeloid leukemia. Blood. 2018 07 26; 132(4):362-368. O'Dwyer K, Freyer DR, Horan JT. PMID: 29895667.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials. Cancer Med. 2018 May 30. Minasian LM, Frazier AL, Sung L, O'Mara A, Kelaghan J, Chang KW, Krailo M, Pollock BH, Reaman G, Freyer DR. PMID: 29846043.
      View in: PubMed   Mentions: 1     Fields:    
    28. Depressive Symptoms and Quality of Life Among Adolescent and Young Adult Cancer Survivors: Impact of Gender and Latino Culture. J Adolesc Young Adult Oncol. 2018 06; 7(3):384-388. Ritt-Olson A, Miller K, Baezconde-Garbanati L, Freyer D, Ramirez C, Hamilton A, Milam J. PMID: 29768076.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Review. JAMA Oncol. 2018 05 01; 4(5):725-734. Siegel SE, Stock W, Johnson RH, Advani A, Muffly L, Douer D, Reed D, Lewis M, Freyer DR, Shah B, Luger S, Hayes-Lattin B, Jaboin JJ, Coccia PF, DeAngelo DJ, Seibel N, Bleyer A. PMID: 29450465.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    30. A prospective, observational cohort study comparing cancer clinical trial availability and enrollment between early adolescents/young adults and children. Cancer. 2018 03 01; 124(5):983-990. Thomas SM, Malvar J, Tran H, Shows J, Freyer DR. PMID: 29149450.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    31. Sexual functioning among young adult cancer patients: A 2-year longitudinal study. Cancer. 2018 01 15; 124(2):398-405. Acquati C, Zebrack BJ, Faul AC, Embry L, Aguilar C, Block R, Hayes-Lattin B, Freyer DR, Cole S. PMID: 29149503.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Prevalence and correlates of health information-seeking among Hispanic and non-Hispanic childhood cancer survivors. Support Care Cancer. 2018 Apr; 26(4):1305-1313. Miller KA, Ramirez CN, Wojcik KY, Ritt-Olson A, Baezconde-Garbanati L, Thomas SM, Freyer DR, Hamilton AS, Milam JE. PMID: 29124416.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Cognitive outcomes among Latino survivors of childhood acute lymphoblastic leukemia and lymphoma: A cross-sectional cohort study using culturally competent, performance-based assessment. Pediatr Blood Cancer. 2018 Feb; 65(2). Bava L, Johns A, Kayser K, Freyer DR. PMID: 28988412.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    34. Child and adolescent self-report symptom measurement in pediatric oncology research: a systematic literature review. Qual Life Res. 2018 02; 27(2):291-319. Pinheiro LC, McFatrich M, Lucas N, Walker JS, Withycombe JS, Hinds PS, Sung L, Tomlinson D, Freyer DR, Mack JW, Baker JN, Reeve BB. PMID: 28879501.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    35. Identifying metrics of success for transitional care practices in childhood cancer survivorship: A qualitative study of survivorship providers. Pediatr Blood Cancer. 2017 Nov; 64(11). Sadak KT, Neglia JP, Freyer DR, Harwood E. PMID: 28557375.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Long-term follow-up of endocrine function among young children with newly diagnosed malignant central nervous system tumors treated with irradiation-avoiding regimens. Pediatr Blood Cancer. 2017 Nov; 64(11). Cochrane AM, Cheung C, Rangan K, Freyer D, Nahata L, Dhall G, Finlay JL. PMID: 28475292.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia. Leuk Lymphoma. 2017 Oct; 58(10):2370-2378. Orgel E, Mueske NM, Sposto R, Gilsanz V, Wren TAL, Freyer DR, Butturini AM, Mittelman SD. PMID: 28278717.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Cognitive Interview-Based Validation of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events in Adolescents with Cancer. J Pain Symptom Manage. 2017 04; 53(4):759-766. Reeve BB, McFatrich M, Pinheiro LC, Freyer DR, Basch EM, Baker JN, Withycombe JS, Sung L, Mack JW, Waldron MK, Mowbray C, Palma D, Hinds PS. PMID: 28062347.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children's Oncology Group. J Clin Oncol. 2017 02; 35(4):440-445. Knight KR, Chen L, Freyer D, Aplenc R, Bancroft M, Bliss B, Dang H, Gillmeister B, Hendershot E, Kraemer DF, Lindenfeld L, Meza J, Neuwelt EA, Pollock BH, Sung L. PMID: 27937095.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    40. Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2017 01; 18(1):63-74. Freyer DR, Chen L, Krailo MD, Knight K, Villaluna D, Bliss B, Pollock BH, Ramdas J, Lange B, Van Hoff D, VanSoelen ML, Wiernikowski J, Neuwelt EA, Sung L. PMID: 27914822.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
    41. Development of a Culturally Competent Service to Improve Academic Functioning for Latino Survivors of Acute Lymphoblastic Leukemia: Methodological Considerations. J Pediatr Oncol Nurs. 2017 May/Jun; 34(3):222-229. Bava L, Johns A, Freyer DR, Ruccione K. PMID: 27889691.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Eliciting the child's voice in adverse event reporting in oncology trials: Cognitive interview findings from the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events initiative. Pediatr Blood Cancer. 2017 03; 64(3). Reeve BB, McFatrich M, Pinheiro LC, Weaver MS, Sung L, Withycombe JS, Baker JN, Mack JW, Waldron MK, Gibson D, Tomlinson D, Freyer DR, Mowbray C, Jacobs S, Palma D, Martens CE, Gold SH, Jackson KD, Hinds PS. PMID: 27650708.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    43. Supporting long-term follow-up of young adult survivors of childhood cancer: Correlates of healthcare self-efficacy. Pediatr Blood Cancer. 2017 02; 64(2):358-363. Miller KA, Wojcik KY, Ramirez CN, Ritt-Olson A, Freyer DR, Hamilton AS, Milam JE. PMID: 27567026.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    44. A parent-directed intervention for addressing academic risk in Latino survivors of childhood leukemia: results of a pilot study. Psychooncology. 2016 10; 25(10):1246-1249. Bava L, Malvar J, Sposto R, Okada M, Gonzalez-Morkos B, Schweers LM, Nuñez C, Ruccione K, Katz ER, Freyer DR. PMID: 27271226.
      View in: PubMed   Mentions: 2     Fields:    
    45. Nonrandomized comparison of neurofibromatosis type 1 and non-neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low-grade glioma: A report from the Children's Oncology Group. Cancer. 2016 06 15; 122(12):1928-36. Ater JL, Xia C, Mazewski CM, Booth TN, Freyer DR, Packer RJ, Sposto R, Vezina G, Pollack IF. PMID: 27061921.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    46. Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program. J Oncol Pract. 2016 Apr; 12(4):e388-95. Roth ME, O'Mara AM, Seibel NL, Dickens DS, Langevin AM, Pollock BH, Freyer DR. PMID: 27026648.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    47. Next steps for adolescent and young adult oncology workshop: An update on progress and recommendations for the future. Cancer. 2016 Apr 01; 122(7):988-99. Smith AW, Seibel NL, Lewis DR, Albritton KH, Blair DF, Blanke CD, Bleyer WA, Freyer DR, Geiger AM, Hayes-Lattin B, Tricoli JV, Wagner LI, Zebrack BJ. PMID: 26849003.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    48. Early injury to cortical and cancellous bone from induction chemotherapy for adolescents and young adults treated for acute lymphoblastic leukemia. Bone. 2016 Apr; 85:131-7. Orgel E, Mueske NM, Wren TA, Gilsanz V, Butturini AM, Freyer DR, Mittelman SD. PMID: 26851412.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    49. Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy. Leuk Lymphoma. 2018 01; 59(1):138-145. Orgel E, Mueske NM, Sposto R, Gilsanz V, Freyer DR, Mittelman SD. PMID: 26818609.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    50. Reconsidering Physical Activity Restrictions for Mononephric Survivors of Childhood Cancer: A Report From the Children's Oncology Group. J Pediatr Oncol Nurs. 2016 07; 33(4):306-13. Okada M, Hockenberry MJ, Koh CJ, Meeske KA, Rangan KE, Rodgers C, Rosenthal Y, Ruccione KS, Freyer DR. PMID: 26589357.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors. Pediatr Blood Cancer. 2016 Mar; 63(3):527-34. Orgel E, O'Neil SH, Kayser K, Smith B, Softley TL, Sherman-Bien S, Counts PA, Murphy D, Dhall G, Freyer DR. PMID: 26529035.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    52. Case-linked analysis of clinical trial enrollment among adolescents and young adults at a National Cancer Institute-designated comprehensive cancer center. Cancer. 2015 Dec 15; 121(24):4398-406. Collins CL, Malvar J, Hamilton AS, Deapen DM, Freyer DR. PMID: 26393950.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    53. Substance use among adolescent and young adult cancer survivors. Psychooncology. 2016 11; 25(11):1357-1362. Milam J, Slaughter R, Meeske K, Ritt-Olson A, Sherman-Bien S, Freyer DR, Kuperberg A, Hamilton AS. PMID: 26315824.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    54. Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia. Pediatrics. 2015 Sep; 136(3):e697-700. Reitman AJ, Coates TD, Freyer DR. PMID: 26283784.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2015 Dec; 62(12):2140-9. Meeske KA, Ji L, Freyer DR, Gaynon P, Ruccione K, Butturini A, Avramis VI, Siegel S, Matloub Y, Seibel NL, Sposto R. PMID: 26173904.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    56. Enhancing Adolescent and Young Adult Oncology Research Within the National Clinical Trials Network: Rationale, Progress, and Emerging Strategies. Semin Oncol. 2015 Oct; 42(5):740-7. Weiss AR, Nichols CR, Freyer DR. PMID: 26433555.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    57. Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group. J Clin Oncol. 2015 Aug 20; 33(24):2639-45. Chow EJ, Asselin BL, Schwartz CL, Doody DR, Leisenring WM, Aggarwal S, Baker KS, Bhatia S, Constine LS, Freyer DR, Lipshultz SE, Armenian SH. PMID: 26014292.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    58. Inclusion of Adolescents and Young Adults in Cancer Clinical Trials. Semin Oncol Nurs. 2015 Aug; 31(3):197-205. Weiss AR, Hayes-Lattin B, Kutny MA, Stock W, Stegenga K, Freyer DR. PMID: 26210198.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    59. Institutional adherence to cardiovascular risk factor screening guidelines for young survivors of acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2015 May; 37(4):e253-7. Lin MH, Wood JR, Mittelman SD, Freyer DR. PMID: 25757021.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    60. Unsanctifying the sanctuary: challenges and opportunities with brain metastases. Neuro Oncol. 2015 May; 17(5):639-51. Puhalla S, Elmquist W, Freyer D, Kleinberg L, Adkins C, Lockman P, McGregor J, Muldoon L, Nesbit G, Peereboom D, Smith Q, Walker S, Neuwelt E. PMID: 25846288.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    61. The Clinical Trials Gap for Adolescents and Young Adults with Cancer: Recent Progress and Conceptual Framework for Continued Research. Curr Pediatr Rep. 2015 Jun; 3(2):137-145. Freyer DR, Seibel NL. PMID: 30613438.
      View in: PubMed   Mentions:
    62. Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia. Blood. 2014 Dec 18; 124(26):3932-8. Orgel E, Tucci J, Alhushki W, Malvar J, Sposto R, Fu CH, Freyer DR, Abdel-Azim H, Mittelman SD. PMID: 25349177.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    63. Cancer-related follow-up care among Hispanic and non-Hispanic childhood cancer survivors: The Project Forward study. Cancer. 2015 Feb 15; 121(4):605-13. Milam JE, Meeske K, Slaughter RI, Sherman-Bien S, Ritt-Olson A, Kuperberg A, Freyer DR, Hamilton AS. PMID: 25345867.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    64. Characterization of transfusion-derived iron deposition in childhood cancer survivors. Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1913-9. Ruccione KS, Wood JC, Sposto R, Malvar J, Chen C, Freyer DR. PMID: 24962841.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    65. Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors. Clin Cancer Res. 2014 Dec 15; 20(24):6314-23. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S. PMID: 24947931.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    66. Carnitine and cardiac dysfunction in childhood cancer survivors treated with anthracyclines. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1109-14. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S. PMID: 24718281.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    67. Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group. J Clin Oncol. 2014 May 01; 32(13):1331-7. Orgel E, Sposto R, Malvar J, Seibel NL, Ladas E, Gaynon PS, Freyer DR. PMID: 24687836.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    68. Comparison of secondary and primary thyroid cancer in adolescents and young adults. Cancer. 2014 Apr 15; 120(8):1155-61. Goldfarb M, Freyer DR. PMID: 24615715.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    69. Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014 Jul; 61(7):1277-81. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. PMID: 24482138.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    70. Facilitating accrual to cancer control and supportive care trials: the clinical research associate perspective. BMC Med Res Methodol. 2013 Dec 31; 13:154. Vanhoff D, Hesser T, Kelly KP, Freyer D, Stork S, Sung L. PMID: 24380578.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    71. Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children's Oncology Group. Cancer. 2013 Dec 01; 119(23):4162-9. Canner J, Alonzo TA, Franklin J, Freyer DR, Gamis A, Gerbing RB, Lange BJ, Meshinchi S, Woods WG, Perentesis J, Horan J. PMID: 24104395.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    72. Young adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen do not need a bone marrow transplant in first remission. Blood. 2013 Jun 27; 121(26):5253-5. Isakoff MS, Freyer DR, Bleyer A. PMID: 23813939.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    73. Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 01; 86(5):942-8. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. PMID: 23726005.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    74. Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: a North American perspective. Pediatr Blood Cancer. 2013 Sep; 60(9):1528-33. Orgel E, Zung L, Ji L, Finklestein J, Feusner J, Freyer DR. PMID: 23441080.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    75. The first step to integrating the child's voice in adverse event reporting in oncology trials: a content validation study among pediatric oncology clinicians. Pediatr Blood Cancer. 2013 Jul; 60(7):1231-6. Reeve BB, Withycombe JS, Baker JN, Hooke MC, Lyons JC, Mowbray C, Wang J, Freyer DR, Joffe S, Sung L, Tomlinson D, Gold SH, Hinds PS. PMID: 23335328.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    76. Children's Oncology Group's 2013 blueprint for research: adolescent and young adult oncology. Pediatr Blood Cancer. 2013 Jun; 60(6):1055-8. Freyer DR, Felgenhauer J, Perentesis J. PMID: 23424167.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    77. Exercise recommendations for childhood cancer survivors exposed to cardiotoxic therapies: an institutional clinical practice initiative. J Pediatr Oncol Nurs. 2012 Sep-Oct; 29(5):246-52. Okada M, Meeske KA, Menteer J, Freyer DR. PMID: 22907680.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    78. Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group. J Clin Oncol. 2012 Jul 20; 30(21):2641-7. Ater JL, Zhou T, Holmes E, Mazewski CM, Booth TN, Freyer DR, Lazarus KH, Packer RJ, Prados M, Sposto R, Vezina G, Wisoff JH, Pollack IF. PMID: 22665535.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    79. Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale. J Clin Oncol. 2012 Jul 01; 30(19):2408-17. Brock PR, Knight KR, Freyer DR, Campbell KC, Steyger PS, Blakley BW, Rassekh SR, Chang KW, Fligor BJ, Rajput K, Sullivan M, Neuwelt EA. PMID: 22547603.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    80. Association of projected transfusional iron burden with treatment intensity in childhood cancer survivors. Pediatr Blood Cancer. 2012 Oct; 59(4):697-702. Ruccione KS, Mudambi K, Sposto R, Fridey J, Ghazarossian S, Freyer DR. PMID: 22190481.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    81. Cancer survivorship practices, services, and delivery: a report from the Children's Oncology Group (COG) nursing discipline, adolescent/young adult, and late effects committees. J Cancer Surviv. 2011 Dec; 5(4):345-57. Eshelman-Kent D, Kinahan KE, Hobbie W, Landier W, Teal S, Friedman D, Nagarajan R, Freyer DR. PMID: 21894490.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    82. Hearing loss among survivors of childhood brain tumors treated with an irradiation-sparing approach. Pediatr Blood Cancer. 2012 Jun; 58(6):953-8. Orgel E, Jain S, Ji L, Pollick L, Si S, Finlay J, Freyer DR. PMID: 21796767.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    83. Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group. Blood. 2011 Mar 17; 117(11):3010-5. Freyer DR, Devidas M, La M, Carroll WL, Gaynon PS, Hunger SP, Seibel NL. PMID: 21193696.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    84. Transition of care for young adult survivors of childhood and adolescent cancer: rationale and approaches. J Clin Oncol. 2010 Nov 10; 28(32):4810-8. Freyer DR. PMID: 20351333.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    85. Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: a report from the children's oncology group. J Clin Oncol. 2009 Nov 01; 27(31):5189-94. Nachman JB, La MK, Hunger SP, Heerema NA, Gaynon PS, Hastings C, Mattano LA, Sather H, Devidas M, Freyer DR, Steinherz PG, Seibel NL. PMID: 19805689.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    86. Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease. Genet Med. 2009 Mar; 11(3):210-9. Nicolino M, Byrne B, Wraith JE, Leslie N, Mandel H, Freyer DR, Arnold GL, Pivnick EK, Ottinger CJ, Robinson PH, Loo JC, Smitka M, Jardine P, Tatò L, Chabrol B, McCandless S, Kimura S, Mehta L, Bali D, Skrinar A, Morgan C, Rangachari L, Corzo D, Kishnani PS. PMID: 19287243.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCTClinical Trials
    87. Prevention of hearing loss in children receiving cisplatin chemotherapy. J Clin Oncol. 2009 Jan 10; 27(2):317-8; author reply 318-9. Freyer DR, Sung L, Reaman GH. PMID: 19064953.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    88. The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. J Pediatr Hematol Oncol. 2008 Nov; 30(11):791-7. Couluris M, Mayer JL, Freyer DR, Sandler E, Xu P, Krischer JP. PMID: 18989154.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    89. Adolescent and young adult oncology: transition of care. Pediatr Blood Cancer. 2008 May; 50(5 Suppl):1116-9. Freyer DR, Brugieres L. PMID: 18360840.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    90. Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood. 2008 Mar 01; 111(5):2548-55. Seibel NL, Steinherz PG, Sather HN, Nachman JB, Delaat C, Ettinger LJ, Freyer DR, Mattano LA, Hastings CA, Rubin CM, Bertolone K, Franklin JL, Heerema NA, Mitchell TL, Pyesmany AF, La MK, Edens C, Gaynon PS. PMID: 18039957.
      View in: PubMed   Mentions: 89     Fields:    Translation:Humans
    91. Measuring the impact of dexrazoxane cardioprotection. Pediatr Blood Cancer. 2007 Apr; 48(4):483-4; author reply 485. Freyer DR. PMID: 16767713.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    92. In sickness and in health: transition of cancer-related care for older adolescents and young adults. Cancer. 2006 Oct 01; 107(7 Suppl):1702-9. Freyer DR, Kibrick-Lazear R. PMID: 16921480.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    93. Multidisciplinary care of the dying adolescent. Child Adolesc Psychiatr Clin N Am. 2006 Jul; 15(3):693-715. Freyer DR, Kuperberg A, Sterken DJ, Pastyrnak SL, Hudson D, Richards T. PMID: 16797445.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    94. Models of care for survivors of childhood cancer. Pediatr Blood Cancer. 2006 Feb; 46(2):159-68. Friedman DL, Freyer DR, Levitt GA. PMID: 16369920.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    95. Flow cytometric diagnosis of X-linked hyper-IgM syndrome: application of an accurate and convenient procedure. J Pediatr Hematol Oncol. 2004 Jun; 26(6):363-70. Freyer DR, Gowans LK, Warzynski M, Lee WI. PMID: 15167349.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    96. Care of the dying adolescent: special considerations. Pediatrics. 2004 Feb; 113(2):381-8. Freyer DR. PMID: 14754953.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    97. Successful nonoperative management of typhlitis in pediatric oncology patients. J Pediatr Surg. 2002 Aug; 37(8):1151-5. Schlatter M, Snyder K, Freyer D. PMID: 12149691.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    98. This work we do: reflections from a pediatric hematology/oncology memorial service. J Pediatr Hematol Oncol. 2001 May; 23(4):213-4. Freyer DR. PMID: 11846298.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    99. Induced hypothermia in experimental pneumococcal meningitis. J Cereb Blood Flow Metab. 2000 May; 20(5):834-8. Angstwurm K, Reuss S, Freyer D, Arnold G, Dirnagl U, Schumann RR, Weber JR. PMID: 10826534.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    100. Intravenous methohexital for brief sedation of pediatric oncology outpatients: physiologic and behavioral responses. Pediatrics. 1997 May; 99(5):E8. Freyer DR, Schwanda AE, Sanfilippo DJ, Hackbarth RM, Hassan NE, Kopec JS, Neirotti MT. PMID: 9113965.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    101. Juvenile xanthogranuloma: forms of systemic disease and their clinical implications. J Pediatr. 1996 Aug; 129(2):227-37. Freyer DR, Kennedy R, Bostrom BC, Kohut G, Dehner LP. PMID: 8765620.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    102. Pleuropulmonary blastoma: a marker for familial disease. J Pediatr. 1996 Feb; 128(2):220-4. Priest JR, Watterson J, Strong L, Huff V, Woods WG, Byrd RL, Friend SH, Newsham I, Amylon MD, Pappo A, Mahoney DH, Langston C, Heyn R, Kohut G, Freyer DR, Bostrom B, Richardson MS, Barredo J, Dehner LP. PMID: 8636815.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    103. Brief unconscious sedation for painful pediatric oncology procedures. Intravenous methohexital with appropriate monitoring is safe and effective. Am J Pediatr Hematol Oncol. 1993 Nov; 15(4):370-6. Schwanda AE, Freyer DR, Sanfilippo DJ, Axtell RA, Fahner JB, Hackbarth RM, Hassan NE, Kopec JS, Waskerwitz MJ. PMID: 8214358.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    104. Extrarenal Wilms' tumor. Unusual presentation in the lumbosacral region. Am J Pediatr Hematol Oncol. 1993 Feb; 15(1):117-9. Fahner JB, Switzer R, Freyer DR, Mann JD, Mann RJ. PMID: 8383474.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    105. Children with cancer: special considerations in the discontinuation of life-sustaining treatment. Med Pediatr Oncol. 1992; 20(2):136-42. Freyer DR. PMID: 1370855.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    106. Regulation of superoxide responses of human neutrophils by adenine compounds. Independence of requirement for cytoplasmic granules. Lab Invest. 1989 Nov; 61(5):515-21. Walker BA, Cunningham TW, Freyer DR, Todd RF, Johnson KJ, Ward PA. PMID: 2554058.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    107. Surface Mo1 (CD11b/CD18) glycoprotein is up-modulated by neutrophils recruited to sites of inflammation in vivo. Inflammation. 1989 Oct; 13(5):495-505. Freyer DR, Morganroth ML, Todd RF. PMID: 2509351.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    108. Primary primitive neuroectodermal tumor of the spinal cord associated with neural tube defect. Pediatr Neurosci. 1989; 15(4):181-7. Freyer DR, Hutchinson RJ, McKeever PE. PMID: 2562067.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    109. Stimulation of human neutrophil adhesive properties by adenine nucleotides. J Immunol. 1988 Jul 15; 141(2):580-6. Freyer DR, Boxer LA, Axtell RA, Todd RF. PMID: 2968405.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    110. The CD11/CD18 leukocyte glycoprotein deficiency. Hematol Oncol Clin North Am. 1988 Mar; 2(1):13-31. Todd RF, Freyer DR. PMID: 3279017.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    111. Modulation of surface CD11/CD18 glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes. Clin Immunol Immunopathol. 1988 Feb; 46(2):272-83. Freyer DR, Morganroth ML, Rogers CE, Arnaout MA, Todd RF. PMID: 3123109.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
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