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David R. Freyer, DO

Title(s)Professor of Clinical Pediatrics
Phone+1 323 361 8953
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    Dr. David Freyer joined Children's Hospital Los Angeles in January 2008. As Director of the LIFE Program, he oversees all aspects of its services, which include clinical assessments of more than 350 patients annually, research regarding their long-term outcomes, and training of fellows, residents, and other health care professionals in the care of childhood cancer survivors. His clinical and research activities have focused principally on cancer survivorship and cancer control, including the recognition, management and prevention of short-and long-term morbidity of treatment, as well as health care transition for young adult survivors of childhood cancer, adolescent and young adult (AYA) oncology, palliative care, and decision-making at the end of life. Dr. Freyer is a member of the Children's Oncology Group where he serves as chair of the AYA Committee, on the Steering Committees for the Survivorship & Outcomes and Cancer Control Committees, and on several protocol and administrative committees. Dr. Freyer graduated magna cum laude from DePauw University, obtained his medical degree from the Des Moines University College of Osteopathic Medicine and Surgery, and completed post-graduate medical training at Chicago College of Osteopathic Medicine and Hospitals, Rush University Medical Center and the University of Michigan Medical Center. In 2007, he obtained a MS degree in Clinical Research Design and Statistical Analysis from the University of Michigan School of Public Health.

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    Project Milestones: Young Adult Cancer Survivorship
    NIH/NCI R01CA237230Jul 1, 2019 - Jun 30, 2024
    Role: Co-Principal Investigator
    CHANGE OF GRANTEE INSTITUTION: Creating and Validating Child Adverse Event Reporting in Oncology Trials
    NIH/NCI R01CA175759Apr 1, 2013 - Mar 31, 2019
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. McFatrich M, Brondon J, Lucas NR, Hinds PS, Maurer SH, Mack JW, Freyer DR, Jacobs SS, Baker JN, Mowbray C, Wang M, Castellino SM, Barz Leahy A, Reeve BB. Mapping child and adolescent self-reported symptom data to clinician-reported adverse event grading to improve pediatric oncology care and research. Cancer. 2019 Sep 25. PMID: 31553494.
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    2. Moke DJ, Hamilton AS, Chehab L, Deapen D, Freyer DR. Obesity and Risk for Second Malignant Neoplasms in Childhood Cancer Survivors: A Case-Control Study Utilizing the California Cancer Registry. Cancer Epidemiol Biomarkers Prev. 2019 Jul 23. PMID: 31337641.
      View in: PubMed
    3. Grace JG, Schweers L, Anazodo A, Freyer DR. Evaluating and providing quality health information for adolescents and young adults with cancer. Pediatr Blood Cancer. 2019 Jul 19; e27931. PMID: 31322817.
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    4. Moke DJ, Tsai K, Hamilton AS, Hwang A, Liu L, Freyer DR, Deapen D. Emerging Cancer Survival Trends, Disparities, and Priorities in Adolescents and Young Adults: A California Cancer Registry-Based Study. JNCI Cancer Spectr. 2019 Jun; 3(2):pkz031. PMID: 31276099.
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    5. Freyer DR, Brock P, Knight K, Reaman G, Cabral S, Robinson PD, Sung L. Interventions for cisplatin-induced hearing loss in children and adolescents with cancer. Lancet Child Adolesc Health. 2019 May 31. PMID: 31160205.
      View in: PubMed
    6. Sadak KT, Szalda D, Lindgren BR, Kinahan KE, Eshelman-Kent D, Schwartz LA, Henderson T, Freyer DR. Transitional care practices, services, and delivery in childhood cancer survivor programs: A survey study of U.S. survivorship providers. Pediatr Blood Cancer. 2019 Aug; 66(8):e27793. PMID: 31099145.
      View in: PubMed
    7. Liu L, Moke DJ, Tsai KY, Hwang A, Freyer DR, Hamilton AS, Zhang J, Cockburn M, Deapen D. Response to Siegel et al. J Natl Cancer Inst. 2019 Feb 21. PMID: 30793169.
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    8. Salsman JM, Bingen K, Barr RD, Freyer DR. Understanding, measuring, and addressing the financial impact of cancer on adolescents and young adults. Pediatr Blood Cancer. 2019 Feb 12; e27660. PMID: 30756484.
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    9. Liu L, Moke DJ, Tsai KY, Hwang A, Freyer DR, Hamilton AS, Zhang J, Cockburn M, Deapen D. A Reappraisal of Sex-Specific Cancer Survival Trends Among Adolescents and Young Adults in the United States. J Natl Cancer Inst. 2018 Oct 15. PMID: 30321398.
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    10. Thomas SM, Malvar J, Tran HH, Shows JT, Freyer DR. A prospective comparison of cancer clinical trial availability and enrollment among adolescents/young adults treated at an adult cancer hospital or affiliated children's hospital. Cancer. 2018 Oct 15; 124(20):4064-4071. PMID: 30291804.
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    11. Freyer DR, Frazier AL, Sung L. Sodium Thiosulfate and Cisplatin-Induced Hearing Loss. N Engl J Med. 2018 09 20; 379(12):1180-1. PMID: 30260148.
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    12. Siegel SE, Advani A, Seibel N, Muffly L, Stock W, Luger S, Shah B, DeAngelo DJ, Freyer DR, Douer D, Johnson RH, Hayes-Lattin B, Lewis M, Jaboin JJ, Coccia PF, Bleyer A. Treatment of young adults with Philadelphia-negative acute lymphoblastic leukemia and lymphoblastic lymphoma: Hyper-CVAD vs. pediatric-inspired regimens. Am J Hematol. 2018 Oct; 93(10):1254-1266. PMID: 30058716.
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    13. Margol AS, Yeo KK, Xia C, Onar A, Robison NJ, Freyer DR, Dhall G. A comparative analysis of clinicopathological features and survival among early adolescents/young adults and children with low-grade glioma: a report from the Children's Oncology Group. J Neurooncol. 2018 Dec; 140(3):575-582. PMID: 30173409.
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    14. Milam J, Slaughter R, Tobin JL, Unger JB, Ritt-Olson A, Freyer DR, Soto D, Hamilton AS. Childhood Cancer Survivorship and Substance Use Behaviors: A Matched Case-Control Study Among Hispanic Adolescents and Young Adults. J Adolesc Health. 2018 07; 63(1):115-117. PMID: 30060847.
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    15. O'Dwyer K, Freyer DR, Horan JT. Treatment strategies for adolescent and young adult patients with acute myeloid leukemia. Blood. 2018 07 26; 132(4):362-368. PMID: 29895667.
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    16. Minasian LM, Frazier AL, Sung L, O'Mara A, Kelaghan J, Chang KW, Krailo M, Pollock BH, Reaman G, Freyer DR. Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials. Cancer Med. 2018 May 30. PMID: 29846043.
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    17. Ritt-Olson A, Miller K, Baezconde-Garbanati L, Freyer D, Ramirez C, Hamilton A, Milam J. Depressive Symptoms and Quality of Life Among Adolescent and Young Adult Cancer Survivors: Impact of Gender and Latino Culture. J Adolesc Young Adult Oncol. 2018 06; 7(3):384-388. PMID: 29768076.
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    18. Siegel SE, Stock W, Johnson RH, Advani A, Muffly L, Douer D, Reed D, Lewis M, Freyer DR, Shah B, Luger S, Hayes-Lattin B, Jaboin JJ, Coccia PF, DeAngelo DJ, Seibel N, Bleyer A. Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Review. JAMA Oncol. 2018 05 01; 4(5):725-734. PMID: 29450465.
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    19. Thomas SM, Malvar J, Tran H, Shows J, Freyer DR. A prospective, observational cohort study comparing cancer clinical trial availability and enrollment between early adolescents/young adults and children. Cancer. 2018 03 01; 124(5):983-990. PMID: 29149450.
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    20. Acquati C, Zebrack BJ, Faul AC, Embry L, Aguilar C, Block R, Hayes-Lattin B, Freyer DR, Cole S. Sexual functioning among young adult cancer patients: A 2-year longitudinal study. Cancer. 2018 01 15; 124(2):398-405. PMID: 29149503.
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    21. Miller KA, Ramirez CN, Wojcik KY, Ritt-Olson A, Baezconde-Garbanati L, Thomas SM, Freyer DR, Hamilton AS, Milam JE. Prevalence and correlates of health information-seeking among Hispanic and non-Hispanic childhood cancer survivors. Support Care Cancer. 2018 Apr; 26(4):1305-1313. PMID: 29124416.
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    22. Bava L, Johns A, Kayser K, Freyer DR. Cognitive outcomes among Latino survivors of childhood acute lymphoblastic leukemia and lymphoma: A cross-sectional cohort study using culturally competent, performance-based assessment. Pediatr Blood Cancer. 2018 Feb; 65(2). PMID: 28988412.
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    23. Pinheiro LC, McFatrich M, Lucas N, Walker JS, Withycombe JS, Hinds PS, Sung L, Tomlinson D, Freyer DR, Mack JW, Baker JN, Reeve BB. Child and adolescent self-report symptom measurement in pediatric oncology research: a systematic literature review. Qual Life Res. 2018 02; 27(2):291-319. PMID: 28879501.
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    24. Sadak KT, Neglia JP, Freyer DR, Harwood E. Identifying metrics of success for transitional care practices in childhood cancer survivorship: A qualitative study of survivorship providers. Pediatr Blood Cancer. 2017 Nov; 64(11). PMID: 28557375.
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    25. Cochrane AM, Cheung C, Rangan K, Freyer D, Nahata L, Dhall G, Finlay JL. Long-term follow-up of endocrine function among young children with newly diagnosed malignant central nervous system tumors treated with irradiation-avoiding regimens. Pediatr Blood Cancer. 2017 Nov; 64(11). PMID: 28475292.
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    26. Orgel E, Mueske NM, Sposto R, Gilsanz V, Wren TAL, Freyer DR, Butturini AM, Mittelman SD. A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia. Leuk Lymphoma. 2017 Oct; 58(10):2370-2378. PMID: 28278717.
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    27. Reeve BB, McFatrich M, Pinheiro LC, Freyer DR, Basch EM, Baker JN, Withycombe JS, Sung L, Mack JW, Waldron MK, Mowbray C, Palma D, Hinds PS. Cognitive Interview-Based Validation of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events in Adolescents with Cancer. J Pain Symptom Manage. 2017 04; 53(4):759-766. PMID: 28062347.
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    28. Knight KR, Chen L, Freyer D, Aplenc R, Bancroft M, Bliss B, Dang H, Gillmeister B, Hendershot E, Kraemer DF, Lindenfeld L, Meza J, Neuwelt EA, Pollock BH, Sung L. Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children's Oncology Group. J Clin Oncol. 2017 02; 35(4):440-445. PMID: 27937095.
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    29. Freyer DR, Chen L, Krailo MD, Knight K, Villaluna D, Bliss B, Pollock BH, Ramdas J, Lange B, Van Hoff D, VanSoelen ML, Wiernikowski J, Neuwelt EA, Sung L. Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2017 01; 18(1):63-74. PMID: 27914822.
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    30. Bava L, Johns A, Freyer DR, Ruccione K. Development of a Culturally Competent Service to Improve Academic Functioning for Latino Survivors of Acute Lymphoblastic Leukemia: Methodological Considerations. J Pediatr Oncol Nurs. 2017 May/Jun; 34(3):222-229. PMID: 27889691.
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    31. Reeve BB, McFatrich M, Pinheiro LC, Weaver MS, Sung L, Withycombe JS, Baker JN, Mack JW, Waldron MK, Gibson D, Tomlinson D, Freyer DR, Mowbray C, Jacobs S, Palma D, Martens CE, Gold SH, Jackson KD, Hinds PS. Eliciting the child's voice in adverse event reporting in oncology trials: Cognitive interview findings from the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events initiative. Pediatr Blood Cancer. 2017 03; 64(3). PMID: 27650708.
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    32. Miller KA, Wojcik KY, Ramirez CN, Ritt-Olson A, Freyer DR, Hamilton AS, Milam JE. Supporting long-term follow-up of young adult survivors of childhood cancer: Correlates of healthcare self-efficacy. Pediatr Blood Cancer. 2017 02; 64(2):358-363. PMID: 27567026.
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    33. Bava L, Malvar J, Sposto R, Okada M, Gonzalez-Morkos B, Schweers LM, Nuñez C, Ruccione K, Katz ER, Freyer DR. A parent-directed intervention for addressing academic risk in Latino survivors of childhood leukemia: results of a pilot study. Psychooncology. 2016 10; 25(10):1246-1249. PMID: 27271226.
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    34. Ater JL, Xia C, Mazewski CM, Booth TN, Freyer DR, Packer RJ, Sposto R, Vezina G, Pollack IF. Nonrandomized comparison of neurofibromatosis type 1 and non-neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low-grade glioma: A report from the Children's Oncology Group. Cancer. 2016 06 15; 122(12):1928-36. PMID: 27061921.
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    35. Roth ME, O'Mara AM, Seibel NL, Dickens DS, Langevin AM, Pollock BH, Freyer DR. Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program. J Oncol Pract. 2016 Apr; 12(4):e388-95. PMID: 27026648.
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    36. Smith AW, Seibel NL, Lewis DR, Albritton KH, Blair DF, Blanke CD, Bleyer WA, Freyer DR, Geiger AM, Hayes-Lattin B, Tricoli JV, Wagner LI, Zebrack BJ. Next steps for adolescent and young adult oncology workshop: An update on progress and recommendations for the future. Cancer. 2016 Apr 01; 122(7):988-99. PMID: 26849003.
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    37. Orgel E, Mueske NM, Wren TA, Gilsanz V, Butturini AM, Freyer DR, Mittelman SD. Early injury to cortical and cancellous bone from induction chemotherapy for adolescents and young adults treated for acute lymphoblastic leukemia. Bone. 2016 Apr; 85:131-7. PMID: 26851412.
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    38. Orgel E, Mueske NM, Sposto R, Gilsanz V, Freyer DR, Mittelman SD. Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy. Leuk Lymphoma. 2018 01; 59(1):138-145. PMID: 26818609.
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    39. Okada M, Hockenberry MJ, Koh CJ, Meeske KA, Rangan KE, Rodgers C, Rosenthal Y, Ruccione KS, Freyer DR. Reconsidering Physical Activity Restrictions for Mononephric Survivors of Childhood Cancer: A Report From the Children's Oncology Group. J Pediatr Oncol Nurs. 2016 07; 33(4):306-13. PMID: 26589357.
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    40. Orgel E, O'Neil SH, Kayser K, Smith B, Softley TL, Sherman-Bien S, Counts PA, Murphy D, Dhall G, Freyer DR. Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors. Pediatr Blood Cancer. 2016 Mar; 63(3):527-34. PMID: 26529035.
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    41. Collins CL, Malvar J, Hamilton AS, Deapen DM, Freyer DR. Case-linked analysis of clinical trial enrollment among adolescents and young adults at a National Cancer Institute-designated comprehensive cancer center. Cancer. 2015 Dec 15; 121(24):4398-406. PMID: 26393950.
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    42. Milam J, Slaughter R, Meeske K, Ritt-Olson A, Sherman-Bien S, Freyer DR, Kuperberg A, Hamilton AS. Substance use among adolescent and young adult cancer survivors. Psychooncology. 2016 11; 25(11):1357-1362. PMID: 26315824.
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    43. Reitman AJ, Coates TD, Freyer DR. Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia. Pediatrics. 2015 Sep; 136(3):e697-700. PMID: 26283784.
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    44. Meeske KA, Ji L, Freyer DR, Gaynon P, Ruccione K, Butturini A, Avramis VI, Siegel S, Matloub Y, Seibel NL, Sposto R. Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2015 Dec; 62(12):2140-9. PMID: 26173904.
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    45. Weiss AR, Nichols CR, Freyer DR. Enhancing Adolescent and Young Adult Oncology Research Within the National Clinical Trials Network: Rationale, Progress, and Emerging Strategies. Semin Oncol. 2015 Oct; 42(5):740-7. PMID: 26433555.
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    46. Chow EJ, Asselin BL, Schwartz CL, Doody DR, Leisenring WM, Aggarwal S, Baker KS, Bhatia S, Constine LS, Freyer DR, Lipshultz SE, Armenian SH. Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group. J Clin Oncol. 2015 Aug 20; 33(24):2639-45. PMID: 26014292.
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    47. Weiss AR, Hayes-Lattin B, Kutny MA, Stock W, Stegenga K, Freyer DR. Inclusion of Adolescents and Young Adults in Cancer Clinical Trials. Semin Oncol Nurs. 2015 Aug; 31(3):197-205. PMID: 26210198.
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    48. Lin MH, Wood JR, Mittelman SD, Freyer DR. Institutional adherence to cardiovascular risk factor screening guidelines for young survivors of acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2015 May; 37(4):e253-7. PMID: 25757021.
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    49. Puhalla S, Elmquist W, Freyer D, Kleinberg L, Adkins C, Lockman P, McGregor J, Muldoon L, Nesbit G, Peereboom D, Smith Q, Walker S, Neuwelt E. Unsanctifying the sanctuary: challenges and opportunities with brain metastases. Neuro Oncol. 2015 May; 17(5):639-51. PMID: 25846288.
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    50. Freyer DR, Seibel NL. The Clinical Trials Gap for Adolescents and Young Adults with Cancer: Recent Progress and Conceptual Framework for Continued Research. Curr Pediatr Rep. 2015 Jun; 3(2):137-145. PMID: 30613438.
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    51. Orgel E, Tucci J, Alhushki W, Malvar J, Sposto R, Fu CH, Freyer DR, Abdel-Azim H, Mittelman SD. Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia. Blood. 2014 Dec 18; 124(26):3932-8. PMID: 25349177.
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    52. Milam JE, Meeske K, Slaughter RI, Sherman-Bien S, Ritt-Olson A, Kuperberg A, Freyer DR, Hamilton AS. Cancer-related follow-up care among Hispanic and non-Hispanic childhood cancer survivors: The Project Forward study. Cancer. 2015 Feb 15; 121(4):605-13. PMID: 25345867.
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    53. Ruccione KS, Wood JC, Sposto R, Malvar J, Chen C, Freyer DR. Characterization of transfusion-derived iron deposition in childhood cancer survivors. Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1913-9. PMID: 24962841.
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    54. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S. Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors. Clin Cancer Res. 2014 Dec 15; 20(24):6314-23. PMID: 24947931.
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    55. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S. Carnitine and cardiac dysfunction in childhood cancer survivors treated with anthracyclines. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1109-14. PMID: 24718281.
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    56. Orgel E, Sposto R, Malvar J, Seibel NL, Ladas E, Gaynon PS, Freyer DR. Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group. J Clin Oncol. 2014 May 01; 32(13):1331-7. PMID: 24687836.
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    57. Goldfarb M, Freyer DR. Comparison of secondary and primary thyroid cancer in adolescents and young adults. Cancer. 2014 Apr 15; 120(8):1155-61. PMID: 24615715.
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    58. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014 Jul; 61(7):1277-81. PMID: 24482138.
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    59. Vanhoff D, Hesser T, Kelly KP, Freyer D, Stork S, Sung L. Facilitating accrual to cancer control and supportive care trials: the clinical research associate perspective. BMC Med Res Methodol. 2013 Dec 31; 13:154. PMID: 24380578.
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    60. Canner J, Alonzo TA, Franklin J, Freyer DR, Gamis A, Gerbing RB, Lange BJ, Meshinchi S, Woods WG, Perentesis J, Horan J. Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children's Oncology Group. Cancer. 2013 Dec 01; 119(23):4162-9. PMID: 24104395.
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    61. Isakoff MS, Freyer DR, Bleyer A. Young adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen do not need a bone marrow transplant in first remission. Blood. 2013 Jun 27; 121(26):5253-5. PMID: 23813939.
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    62. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 01; 86(5):942-8. PMID: 23726005.
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    63. Orgel E, Zung L, Ji L, Finklestein J, Feusner J, Freyer DR. Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: a North American perspective. Pediatr Blood Cancer. 2013 Sep; 60(9):1528-33. PMID: 23441080.
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    64. Reeve BB, Withycombe JS, Baker JN, Hooke MC, Lyons JC, Mowbray C, Wang J, Freyer DR, Joffe S, Sung L, Tomlinson D, Gold SH, Hinds PS. The first step to integrating the child's voice in adverse event reporting in oncology trials: a content validation study among pediatric oncology clinicians. Pediatr Blood Cancer. 2013 Jul; 60(7):1231-6. PMID: 23335328.
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    65. Freyer DR, Felgenhauer J, Perentesis J. Children's Oncology Group's 2013 blueprint for research: adolescent and young adult oncology. Pediatr Blood Cancer. 2013 Jun; 60(6):1055-8. PMID: 23424167.
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    66. Okada M, Meeske KA, Menteer J, Freyer DR. Exercise recommendations for childhood cancer survivors exposed to cardiotoxic therapies: an institutional clinical practice initiative. J Pediatr Oncol Nurs. 2012 Sep-Oct; 29(5):246-52. PMID: 22907680.
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    67. Ater JL, Zhou T, Holmes E, Mazewski CM, Booth TN, Freyer DR, Lazarus KH, Packer RJ, Prados M, Sposto R, Vezina G, Wisoff JH, Pollack IF. Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group. J Clin Oncol. 2012 Jul 20; 30(21):2641-7. PMID: 22665535.
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    68. Brock PR, Knight KR, Freyer DR, Campbell KC, Steyger PS, Blakley BW, Rassekh SR, Chang KW, Fligor BJ, Rajput K, Sullivan M, Neuwelt EA. Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale. J Clin Oncol. 2012 Jul 01; 30(19):2408-17. PMID: 22547603.
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    69. Ruccione KS, Mudambi K, Sposto R, Fridey J, Ghazarossian S, Freyer DR. Association of projected transfusional iron burden with treatment intensity in childhood cancer survivors. Pediatr Blood Cancer. 2012 Oct; 59(4):697-702. PMID: 22190481.
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    70. Eshelman-Kent D, Kinahan KE, Hobbie W, Landier W, Teal S, Friedman D, Nagarajan R, Freyer DR. Cancer survivorship practices, services, and delivery: a report from the Children's Oncology Group (COG) nursing discipline, adolescent/young adult, and late effects committees. J Cancer Surviv. 2011 Dec; 5(4):345-57. PMID: 21894490.
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    71. Orgel E, Jain S, Ji L, Pollick L, Si S, Finlay J, Freyer DR. Hearing loss among survivors of childhood brain tumors treated with an irradiation-sparing approach. Pediatr Blood Cancer. 2012 Jun; 58(6):953-8. PMID: 21796767.
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    72. Freyer DR, Devidas M, La M, Carroll WL, Gaynon PS, Hunger SP, Seibel NL. Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group. Blood. 2011 Mar 17; 117(11):3010-5. PMID: 21193696.
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    73. Freyer DR. Transition of care for young adult survivors of childhood and adolescent cancer: rationale and approaches. J Clin Oncol. 2010 Nov 10; 28(32):4810-8. PMID: 20351333.
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    74. Nachman JB, La MK, Hunger SP, Heerema NA, Gaynon PS, Hastings C, Mattano LA, Sather H, Devidas M, Freyer DR, Steinherz PG, Seibel NL. Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: a report from the children's oncology group. J Clin Oncol. 2009 Nov 01; 27(31):5189-94. PMID: 19805689.
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    75. Nicolino M, Byrne B, Wraith JE, Leslie N, Mandel H, Freyer DR, Arnold GL, Pivnick EK, Ottinger CJ, Robinson PH, Loo JC, Smitka M, Jardine P, Tatò L, Chabrol B, McCandless S, Kimura S, Mehta L, Bali D, Skrinar A, Morgan C, Rangachari L, Corzo D, Kishnani PS. Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease. Genet Med. 2009 Mar; 11(3):210-9. PMID: 19287243.
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    76. Freyer DR, Sung L, Reaman GH. Prevention of hearing loss in children receiving cisplatin chemotherapy. J Clin Oncol. 2009 Jan 10; 27(2):317-8; author reply 318-9. PMID: 19064953.
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    77. Couluris M, Mayer JL, Freyer DR, Sandler E, Xu P, Krischer JP. The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. J Pediatr Hematol Oncol. 2008 Nov; 30(11):791-7. PMID: 18989154.
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    78. Freyer DR, Brugieres L. Adolescent and young adult oncology: transition of care. Pediatr Blood Cancer. 2008 May; 50(5 Suppl):1116-9. PMID: 18360840.
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    79. Seibel NL, Steinherz PG, Sather HN, Nachman JB, Delaat C, Ettinger LJ, Freyer DR, Mattano LA, Hastings CA, Rubin CM, Bertolone K, Franklin JL, Heerema NA, Mitchell TL, Pyesmany AF, La MK, Edens C, Gaynon PS. Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood. 2008 Mar 01; 111(5):2548-55. PMID: 18039957.
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    80. Freyer DR. Measuring the impact of dexrazoxane cardioprotection. Pediatr Blood Cancer. 2007 Apr; 48(4):483-4; author reply 485. PMID: 16767713.
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    81. Freyer DR, Kibrick-Lazear R. In sickness and in health: transition of cancer-related care for older adolescents and young adults. Cancer. 2006 Oct 01; 107(7 Suppl):1702-9. PMID: 16921480.
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    82. Freyer DR, Kuperberg A, Sterken DJ, Pastyrnak SL, Hudson D, Richards T. Multidisciplinary care of the dying adolescent. Child Adolesc Psychiatr Clin N Am. 2006 Jul; 15(3):693-715. PMID: 16797445.
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    83. Friedman DL, Freyer DR, Levitt GA. Models of care for survivors of childhood cancer. Pediatr Blood Cancer. 2006 Feb; 46(2):159-68. PMID: 16369920.
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    84. Freyer DR, Gowans LK, Warzynski M, Lee WI. Flow cytometric diagnosis of X-linked hyper-IgM syndrome: application of an accurate and convenient procedure. J Pediatr Hematol Oncol. 2004 Jun; 26(6):363-70. PMID: 15167349.
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    85. Freyer DR. Care of the dying adolescent: special considerations. Pediatrics. 2004 Feb; 113(2):381-8. PMID: 14754953.
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    86. Schlatter M, Snyder K, Freyer D. Successful nonoperative management of typhlitis in pediatric oncology patients. J Pediatr Surg. 2002 Aug; 37(8):1151-5. PMID: 12149691.
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    87. Freyer DR. This work we do: reflections from a pediatric hematology/oncology memorial service. J Pediatr Hematol Oncol. 2001 May; 23(4):213-4. PMID: 11846298.
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    88. Angstwurm K, Reuss S, Freyer D, Arnold G, Dirnagl U, Schumann RR, Weber JR. Induced hypothermia in experimental pneumococcal meningitis. J Cereb Blood Flow Metab. 2000 May; 20(5):834-8. PMID: 10826534.
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    89. Freyer DR, Schwanda AE, Sanfilippo DJ, Hackbarth RM, Hassan NE, Kopec JS, Neirotti MT. Intravenous methohexital for brief sedation of pediatric oncology outpatients: physiologic and behavioral responses. Pediatrics. 1997 May; 99(5):E8. PMID: 9113965.
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    90. Freyer DR, Kennedy R, Bostrom BC, Kohut G, Dehner LP. Juvenile xanthogranuloma: forms of systemic disease and their clinical implications. J Pediatr. 1996 Aug; 129(2):227-37. PMID: 8765620.
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    91. Priest JR, Watterson J, Strong L, Huff V, Woods WG, Byrd RL, Friend SH, Newsham I, Amylon MD, Pappo A, Mahoney DH, Langston C, Heyn R, Kohut G, Freyer DR, Bostrom B, Richardson MS, Barredo J, Dehner LP. Pleuropulmonary blastoma: a marker for familial disease. J Pediatr. 1996 Feb; 128(2):220-4. PMID: 8636815.
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    92. Schwanda AE, Freyer DR, Sanfilippo DJ, Axtell RA, Fahner JB, Hackbarth RM, Hassan NE, Kopec JS, Waskerwitz MJ. Brief unconscious sedation for painful pediatric oncology procedures. Intravenous methohexital with appropriate monitoring is safe and effective. Am J Pediatr Hematol Oncol. 1993 Nov; 15(4):370-6. PMID: 8214358.
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    93. Fahner JB, Switzer R, Freyer DR, Mann JD, Mann RJ. Extrarenal Wilms' tumor. Unusual presentation in the lumbosacral region. Am J Pediatr Hematol Oncol. 1993 Feb; 15(1):117-9. PMID: 8383474.
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    94. Freyer DR. Children with cancer: special considerations in the discontinuation of life-sustaining treatment. Med Pediatr Oncol. 1992; 20(2):136-42. PMID: 1370855.
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    95. Walker BA, Cunningham TW, Freyer DR, Todd RF, Johnson KJ, Ward PA. Regulation of superoxide responses of human neutrophils by adenine compounds. Independence of requirement for cytoplasmic granules. Lab Invest. 1989 Nov; 61(5):515-21. PMID: 2554058.
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    96. Freyer DR, Morganroth ML, Todd RF. Surface Mo1 (CD11b/CD18) glycoprotein is up-modulated by neutrophils recruited to sites of inflammation in vivo. Inflammation. 1989 Oct; 13(5):495-505. PMID: 2509351.
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    97. Freyer DR, Hutchinson RJ, McKeever PE. Primary primitive neuroectodermal tumor of the spinal cord associated with neural tube defect. Pediatr Neurosci. 1989; 15(4):181-7. PMID: 2562067.
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    98. Freyer DR, Boxer LA, Axtell RA, Todd RF. Stimulation of human neutrophil adhesive properties by adenine nucleotides. J Immunol. 1988 Jul 15; 141(2):580-6. PMID: 2968405.
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    99. Todd RF, Freyer DR. The CD11/CD18 leukocyte glycoprotein deficiency. Hematol Oncol Clin North Am. 1988 Mar; 2(1):13-31. PMID: 3279017.
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    100. Freyer DR, Morganroth ML, Rogers CE, Arnaout MA, Todd RF. Modulation of surface CD11/CD18 glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes. Clin Immunol Immunopathol. 1988 Feb; 46(2):272-83. PMID: 3123109.
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