Etan Orgel, MD

Title(s)Associate Professor of Clinical Pediatrics
AddressCHL 4650 W Sunset Blvd,
Off Campus
Los Angeles CA 90027
Phone+1 323 361 2121
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    Dr. Orgel is currently an attending physician on the Medical Supportive Care/Survivorship and Supportive Care Program and the Leukemia and Lymphoma Team within the Division of pediatric Hematology, Oncology, and Blood & Marrow Transplantation at the Children's Hospital Los Angeles (Los Angeles, CA). Dr. Orgel's clinical specialty focuses on higher risk and rare malignant hematology, and specifically, Mixed-Phenotype Acute Leukemia (MPAL). He possesses an academic appointment as an Associate Professor of Clinical Pediatrics in the Keck School of Medicine of the University of Southern California (USC) and earned a Masters of Science in Clinical and Biomedical Investigations from the Department of Preventive Medicine at USC.

    Dr. Orgel's primary research interest lies in the field of medical supportive care or "cancer control" (reducing acute and late treatment-related toxicities). The goal of his translational research is to target specific toxic effects to widen therapeutic windows for common chemotherapies and/or improve the quality of life of children with cancer. Currently, Dr. Orgel's investigator- initiated research includes two primary areas of emphasis (1) studying new agents and novel strategies to reduce hearing loss from chemotherapy (cisplatin), and (2) targeting overweight and obesity in pediatric ALL to reduce chemoresistance and improve survival.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia. Blood. 2021 07 15; 138(2):199-202. Mittelman SD, Kim J, Raca G, Li G, Oberley MJ, Orgel E. PMID: 33876219.
      View in: PubMed   Mentions:    Fields:    
    2. Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells. Front Oncol. 2021; 11:665763. Tucci J, Chen T, Margulis K, Orgel E, Paszkiewicz RL, Cohen MD, Oberley MJ, Wahhab R, Jones AE, Divakaruni AS, Hsu CC, Noll SE, Sheng X, Zare RN, Mittelman SD. PMID: 33968771.
      View in: PubMed   Mentions:
    3. Caloric and nutrient restriction to augment chemotherapy efficacy for acute lymphoblastic leukemia: the IDEAL trial. Blood Adv. 2021 04 13; 5(7):1853-1861. Orgel E, Framson C, Buxton R, Kim J, Li G, Tucci J, Freyer DR, Sun W, Oberley MJ, Dieli-Conwright C, Mittelman SD. PMID: 33792627.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    4. Hearing Loss Risk in Pediatric Patients Treated with Cranial Irradiation and Cisplatin-Based Chemotherapy. Int J Radiat Oncol Biol Phys. 2021 Aug 01; 110(5):1488-1495. Cohen-Cutler S, Wong K, Mena V, Sianto K, Wright MA, Olch A, Orgel E. PMID: 33677052.
      View in: PubMed   Mentions:    Fields:    
    5. Prevalence and risk factors for cisplatin-induced hearing loss in children, adolescents, and young adults: a multi-institutional North American cohort study. Lancet Child Adolesc Health. 2021 04; 5(4):274-283. Moke DJ, Luo C, Millstein J, Knight KR, Rassekh SR, Brooks B, Ross CJD, Wright M, Mena V, Rushing T, Esbenshade AJ, Carleton BC, Orgel E. PMID: 33581749.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Mixed Phenotype Acute Leukemia: Current Approaches to Diagnosis and Treatment. Curr Oncol Rep. 2021 02 05; 23(2):22. Alexander TB, Orgel E. PMID: 33544265.
      View in: PubMed   Mentions:    Fields:    
    7. Effect of Body Fat on Population Pharmacokinetics of High-Dose Methotrexate in Pediatric Patients With Acute Lymphoblastic Leukemia. J Clin Pharmacol. 2021 Jun; 61(6):755-762. Orgel E, Nabais T, Douglas C, Mittelman SD, Neely M. PMID: 33314168.
      View in: PubMed   Mentions:    Fields:    
    8. Association of body mass index with toxicity and survival in pediatric patients treated with cisplatin-containing regimens. Pediatr Hematol Oncol. 2021 Apr; 38(3):239-250. Bhandari R, Scott E, Yeh MY, Wong K, Rushing T, Huh W, Orgel E. PMID: 33170064.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Preexisting or therapy-induced mutations in relapsed acute lymphoblastic leukemia? Blood. 2020 11 05; 136(19):2233-2235. Gaynon PS, Orgel E, Ji L. PMID: 32603411.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Assessment of provider perspectives on otoprotection research for children and adolescents: A Children's Oncology Group Cancer Control and Supportive Care Committee survey. Pediatr Blood Cancer. 2020 11; 67(11):e28647. Orgel E, Freyer DR, Ullrich NJ, Hardy KK, Thomas SM, Dvorak CC, Esbenshade AJ. PMID: 32886425.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Integrin a6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020 07 09; 136(2):210-223. Gang EJ, Kim HN, Hsieh YT, Ruan Y, Ogana HA, Lee S, Pham J, Geng H, Park E, Klemm L, Willman CL, Carroll WL, Mittelman SD, Orgel E, Oberley MJ, Parekh C, Abdel-Azim H, Bhojwani D, Wayne AS, De Arcangelis A, Georges-Labouesse E, Wayner E, Bonig H, Minasyan A, Ten Hoeve J, Graeber TG, Müschen M, Heisterkamp N, Kim YM. PMID: 32219444.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    12. Significance of minimal residual disease in pediatric mixed phenotype acute leukemia: a multicenter cohort study. Leukemia. 2020 07; 34(7):1741-1750. Oberley MJ, Raikar SS, Wertheim GB, Malvar J, Sposto R, Rabin KR, Punia JN, Seif AE, Cahen VC, Schore RJ, Luca DC, Guinipero T, Woods WG, O'Gorman MRG, Orgel E. PMID: 32060402.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study. Lancet Haematol. 2020 Mar; 7(3):e238-e246. Myers KC, Furutani E, Weller E, Siegele B, Galvin A, Arsenault V, Alter BP, Boulad F, Bueso-Ramos C, Burroughs L, Castillo P, Connelly J, Davies SM, DiNardo CD, Hanif I, Ho RH, Karras N, Manalang M, McReynolds LJ, Nakano TA, Nalepa G, Norkin M, Oberley MJ, Orgel E, Pastore YD, Rosenthal J, Walkovich K, Larson J, Malsch M, Elghetany MT, Fleming MD, Shimamura A. PMID: 31879230.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force. Cancer. 2020 02 01; 126(3):593-601. Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-McKay PA, Horan JT, Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force . PMID: 31661160.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Association between Vitamin D and Risk for Early and Late Post-Transplant Complications. Biol Blood Marrow Transplant. 2020 02; 26(2):343-350. Bhandari R, Malvar J, Sacapano A, Aguayo-Hiraldo P, Jodele S, Orgel E. PMID: 31654787.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Improving the Timeliness of Chemotherapy Administration in the Bone Marrow Transplant Unit. Biol Blood Marrow Transplant. 2020 01; 26(1):150-156. Bhandari R, Orgel E, Rushing T, Malicse K, Evangelista V, Jodele S, Dandoy CE. PMID: 31562961.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia. Leuk Lymphoma. 2020 02; 61(2):420-428. Sea JL, Orgel E, Chen T, Paszkiewicz RL, Krall AS, Oberley MJ, Stiles L, Mittelman SD. PMID: 31526067.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    18. Mechanisms by Which Obesity Impacts Survival from Acute Lymphoblastic Leukemia. J Natl Cancer Inst Monogr. 2019 09 01; 2019(54):152-156. Orgel E, Sea JL, Mittelman SD. PMID: 31532535.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    19. Myosteatosis in adolescents and young adults treated for acute lymphoblastic leukemia. Leuk Lymphoma. 2019 12; 60(13):3146-3153. Mueske NM, Mittelman SD, Wren TAL, Gilsanz V, Orgel E. PMID: 31264493.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    20. Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium. Lancet Oncol. 2019 01; 20(1):e29-e41. Clemens E, van den Heuvel-Eibrink MM, Mulder RL, Kremer LCM, Hudson MM, Skinner R, Constine LS, Bass JK, Kuehni CE, Langer T, van Dalen EC, Bardi E, Bonne NX, Brock PR, Brooks B, Carleton B, Caron E, Chang KW, Johnston K, Knight K, Nathan PC, Orgel E, Prasad PK, Rottenberg J, Scheinemann K, de Vries ACH, Walwyn T, Weiss A, Am Zehnhoff-Dinnesen A, Cohn RJ, Landier W, International Guideline Harmonization Group ototoxicity group . PMID: 30614474.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    21. The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature. 2018 10; 562(7727):373-379. Alexander TB, Gu Z, Iacobucci I, Dickerson K, Choi JK, Xu B, Payne-Turner D, Yoshihara H, Loh ML, Horan J, Buldini B, Basso G, Elitzur S, de Haas V, Zwaan CM, Yeoh A, Reinhardt D, Tomizawa D, Kiyokawa N, Lammens T, De Moerloose B, Catchpoole D, Hori H, Moorman A, Moore AS, Hrusak O, Meshinchi S, Orgel E, Devidas M, Borowitz M, Wood B, Heerema NA, Carrol A, Yang YL, Smith MA, Davidsen TM, Hermida LC, Gesuwan P, Marra MA, Ma Y, Mungall AJ, Moore RA, Jones SJM, Valentine M, Janke LJ, Rubnitz JE, Pui CH, Ding L, Liu Y, Zhang J, Nichols KE, Downing JR, Cao X, Shi L, Pounds S, Newman S, Pei D, Guidry Auvil JM, Gerhard DS, Hunger SP, Inaba H, Mullighan CG. PMID: 30209392.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    22. Adipocyte metabolism of the chemotherapy daunorubicin. Oncoscience. 2018 May; 5(5-6):146-147. Mittelman SD, Orgel E. PMID: 30035170.
      View in: PubMed   Mentions:
    23. Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia. Thromb Res. 2018 05; 165:44-50. Prasca S, Carmona R, Ji L, Ko RH, Bhojwani D, Rawlins YA, Mittelman SD, Young G, Orgel E. PMID: 29567586.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis. Leukemia. 2018 07; 32(7):1515-1528. Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E. PMID: 29550836.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    25. Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens. Pediatr Blood Cancer. 2018 03; 65(3). Denton CC, Rawlins YA, Oberley MJ, Bhojwani D, Orgel E. PMID: 29218844.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    26. TACL'ing supportive care needs in pediatric early phase clinical trials for acute leukemia: A report from the therapeutic advances in childhood leukemia & lymphoma (TACL) consortium supportive care committee. Pediatr Hematol Oncol. 2017 Sep - Oct; 34(6-7):409-417. Orgel E, Auletta JJ. PMID: 29190169.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin. Mol Cancer Res. 2017 12; 15(12):1704-1713. Sheng X, Parmentier JH, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright CM, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD. PMID: 29117945.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    28. Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018 Feb; 65(2). Moke DJ, Oberley MJ, Bhojwani D, Parekh C, Orgel E. PMID: 28876513.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Clinical Significance of Isolated Myeloperoxidase Expression in Pediatric B-Lymphoblastic Leukemia. Am J Clin Pathol. 2017 04 01; 147(4):374-381. Oberley MJ, Li S, Orgel E, Phei Wee C, Hagiya A, O'Gorman MRG. PMID: 28340210.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia. Leuk Lymphoma. 2017 Oct; 58(10):2370-2378. Orgel E, Mueske NM, Sposto R, Gilsanz V, Wren TAL, Freyer DR, Butturini AM, Mittelman SD. PMID: 28278717.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Treatment-related adverse events associated with a modified UK ALLR3 induction chemotherapy backbone for childhood relapsed/refractory acute lymphoblastic leukemia. Pediatr Blood Cancer. 2016 11; 63(11):1943-8. Sun W, Orgel E, Malvar J, Sposto R, Wilkes JJ, Gardner R, Tolbert VP, Smith A, Hur M, Hoffman J, Rheingold SR, Burke MJ, Wayne AS. PMID: 27437864.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Association of body mass index and survival in pediatric leukemia: a meta-analysis. Am J Clin Nutr. 2016 Mar; 103(3):808-17. Orgel E, Genkinger JM, Aggarwal D, Sung L, Nieder M, Ladas EJ. PMID: 26864366.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    33. Early injury to cortical and cancellous bone from induction chemotherapy for adolescents and young adults treated for acute lymphoblastic leukemia. Bone. 2016 Apr; 85:131-7. Orgel E, Mueske NM, Wren TA, Gilsanz V, Butturini AM, Freyer DR, Mittelman SD. PMID: 26851412.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy. Leuk Lymphoma. 2018 01; 59(1):138-145. Orgel E, Mueske NM, Sposto R, Gilsanz V, Freyer DR, Mittelman SD. PMID: 26818609.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    35. Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors. Pediatr Blood Cancer. 2016 Mar; 63(3):527-34. Orgel E, O'Neil SH, Kayser K, Smith B, Softley TL, Sherman-Bien S, Counts PA, Murphy D, Dhall G, Freyer DR. PMID: 26529035.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    36. Clinical and microbiologic outcomes of quinolone prophylaxis in children with acute myeloid leukemia. Pediatr Infect Dis J. 2015 Apr; 34(4):e78-84. Felsenstein S, Orgel E, Rushing T, Fu C, Hoffman JA. PMID: 25764103.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    37. Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia. Blood. 2014 Dec 18; 124(26):3932-8. Orgel E, Tucci J, Alhushki W, Malvar J, Sposto R, Fu CH, Freyer DR, Abdel-Azim H, Mittelman SD. PMID: 25349177.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    38. Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group. J Clin Oncol. 2014 May 01; 32(13):1331-7. Orgel E, Sposto R, Malvar J, Seibel NL, Ladas E, Gaynon PS, Freyer DR. PMID: 24687836.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    39. Infectious morbidity by catheter type in neutropenic children with cancer. Pediatr Infect Dis J. 2014 Mar; 33(3):263-6. Orgel E, Ji L, Pastor W, Schore RJ. PMID: 24263218.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Efficacy and tolerability of intravenous pentamidine isethionate for Pneumocystis jiroveci prophylaxis in a pediatric oncology population. Pediatr Infect Dis J. 2014 Mar; 33(3):319-21. Orgel E, Rushing T. PMID: 24030353.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    41. Why Healthcare Providers Should Focus on the Fertility of AYA Cancer Survivors: It's Not Too Late! Front Oncol. 2013 Oct 07; 3:248. Murphy D, Orgel E, Termuhlen A, Shannon S, Warren K, Quinn GP. PMID: 24109589.
      View in: PubMed   Mentions:
    42. The links between insulin resistance, diabetes, and cancer. Curr Diab Rep. 2013 Apr; 13(2):213-22. Orgel E, Mittelman SD. PMID: 23271574.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    43. Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: a North American perspective. Pediatr Blood Cancer. 2013 Sep; 60(9):1528-33. Orgel E, Zung L, Ji L, Finklestein J, Feusner J, Freyer DR. PMID: 23441080.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    44. Hearing loss among survivors of childhood brain tumors treated with an irradiation-sparing approach. Pediatr Blood Cancer. 2012 Jun; 58(6):953-8. Orgel E, Jain S, Ji L, Pollick L, Si S, Finlay J, Freyer DR. PMID: 21796767.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    45. A failing medical educational model: a self-assessment by physicians at all levels of training of ability and comfort to deliver bad news. J Palliat Med. 2010 Jun; 13(6):677-83. Orgel E, McCarter R, Jacobs S. PMID: 20597701.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
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