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Guy A. Young, MD

Title(s)Professor of Pediatrics (Clinical Scholar)
AddressCHL Mail Stop 54
Off Campus
Los Angeles CA 90089
Phone+1 323 361 4628
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    Collapse Biography 
    Collapse Awards and Honors
    National Hemophilia Foundation2013Physician of the Year

    Collapse Overview 
    Collapse Overview
    Following medical school, I completed my residency in pediatrics at Schneider Children's Hospital-Long Island Jewish Medical Center which is part of the Albert Einstein College of Medicine. I then completed a fellowship in pediatric hematology/oncology at Children's National Medical Center in Washington, DC which is part of the George Washington University School of Medicine. I then began my research career at the Children's Hospital of Orange County under the mentorship of Dr. Diane Nugent. There, I became interested in improving the treatment for patients with hemophilia and inhibitors and for children with blood clots. I received my first independent grants there inculding a grant from the FDA to study a new anticoagulant in children. In addition, I became interested in thromboelastography. In 2007, I moved the Children's Hospital Los Angeles where I am continuing to perform research in the same areas as I had started in Orange County.

    Collapse Research 
    Collapse Research Activities and Funding
    Dose-finding, pharmacokinetic, safety and efficacy of bivalirudin in children
    NIH/NHLBI R01HL095110Sep 26, 2008 - Jul 31, 2010
    Role: Principal Investigator
    FONDAPARINUM IN CHILDREN WITH THROMBOSIS
    FDA R01FD003091Mar 1, 2007 - May 31, 2009
    Role: Principal Investigator

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    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Laboratory assay measurement of modified clotting factor concentrates: a review of the literature and recommendations for practice. J Thromb Haemost. 2019 Apr; 17(4):567-573. Young GA, Perry DJ. PMID: 30667575.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Anticoagulation Therapies in Children. Pediatr Clin North Am. 2017 12; 64(6):1257-1269. Young G. PMID: 29173784.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Anticoagulation in children: Making the most of little patients and little evidence. Blood Cells Mol Dis. 2017 09; 67:48-53. Young G, Male C, van Ommen CH. PMID: 28552476.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Nonacog beta pegol (N9-GP) in haemophilia B: A multinational phase III safety and efficacy extension trial (paradigm™4). Thromb Res. 2016 May; 141:69-76. Young G, Collins PW, Colberg T, Chuansumrit A, Hanabusa H, Lentz SR, Mahlangu J, Mauser-Bunschoten EP, Négrier C, Oldenburg J, Patiroglu T, Santagostino E, Tehranchi R, Zak M, Karim FA. PMID: 26970716.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    5. Evaluation of algorithms for the treatment of problem bleeding episodes in patients with hemophilia having inhibitors. Clin Appl Thromb Hemost. 2015 Jan; 21(1):10-8. Young G, Teitel J, d'Oiron R, Leissinger C, Berntorp E. PMID: 25343956.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives. Blood. 2013 Mar 14; 121(11):1944-50. Young G, Sørensen B, Dargaud Y, Negrier C, Brummel-Ziedins K, Key NS. PMID: 23319573.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    7. PRO-PACT: retrospective observational study on the prophylactic use of recombinant factor VIIa in hemophilia patients with inhibitors. Thromb Res. 2012 Dec; 130(6):864-70. Young G, Auerswald G, Jimenez-Yuste V, Lambert T, Morfini M, Santagostino E, Blanchette V. PMID: 22964026.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    8. From boy to man: recommendations for the transition process in haemophilia. Haemophilia. 2012 Jul; 18 Suppl 5:27-32. Young G. PMID: 22757681.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Dosing and effectiveness of recombinant activated factor VII (rFVIIA) in congenital haemophilia with inhibitors by bleed type and location: the experience of the Haemophilia and Thrombosis Research Society (HTRS) Registry (2004-2008). Haemophilia. 2012 Nov; 18(6):990-6. Young G, Cooper DL, Gut RZ. PMID: 22631073.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. New challenges in hemophilia: long-term outcomes and complications. Hematology Am Soc Hematol Educ Program. 2012; 2012:362-8. Young G. PMID: 23233605.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    11. Patient/caregiver-reported recombinant factor VIIa (rFVIIa) dosing: home treatment of acute bleeds in the Dosing Observational Study in Hemophilia (DOSE). Haemophilia. 2012 May; 18(3):392-9. Young G, Shapiro AD, Walsh CE, Gruppo RA, Gut RZ, Cooper DL. PMID: 22171621.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Old and new antithrombotic drugs in neonates and infants. Semin Fetal Neonatal Med. 2011 Dec; 16(6):349-54. Young G. PMID: 21816695.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. When should prophylaxis therapy in inhibitor patients be considered? Haemophilia. 2011 Sep; 17(5):e849-57. Young G, Auerswald G, Jimenez-Yuste V, Konkle BA, Lambert T, Morfini M, Santagostino E, Blanchette V. PMID: 21418444.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. FondaKIDS: a prospective pharmacokinetic and safety study of fondaparinux in children between 1 and 18 years of age. Pediatr Blood Cancer. 2011 Dec 01; 57(6):1049-54. Young G, Yee DL, O'Brien SH, Khanna R, Barbour A, Nugent DJ. PMID: 21319285.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    15. New anticoagulants in children: a review of recent studies and a look to the future. Thromb Res. 2011 Feb; 127(2):70-4. Young G. PMID: 21129768.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: an open-label, safety, efficacy, and pharmacokinetic study. Pediatr Blood Cancer. 2011 Jul 01; 56(7):1103-9. Young G, Boshkov LK, Sullivan JE, Raffini LJ, Cox DS, Boyle DA, Kallender H, Tarka EA, Soffer J, Hursting MJ. PMID: 21488155.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    17. Transitioning issues in adolescent to young adult hemophilia patients with inhibitors: an approach for a growing population. Blood Coagul Fibrinolysis. 2010 Sep; 21 Suppl 1:S7-10. Young G. PMID: 20855989.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Comparison of kaolin and tissue factor activated thromboelastography in haemophilia. Haemophilia. 2010 May; 16(3):518-24. Young G, Zhang R, Miller R, Yassin D, Nugent DJ. PMID: 20028419.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. Off-label use of rFVIIa in children with excessive bleeding: a consecutive study of 153 off-label uses in 139 children. Pediatr Blood Cancer. 2009 Aug; 53(2):179-83. Young G, Wicklund B, Neff P, Johnson C, Nugent DJ. PMID: 19415741.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. Evaluation of thromboelastography for monitoring recombinant activated factor VII ex vivo in haemophilia A and B patients with inhibitors: a multicentre trial. Blood Coagul Fibrinolysis. 2008 Jun; 19(4):276-82. Young G, Ebbesen LS, Viuff D, Di Paola J, Konkle BA, Negrier C, Pasi J, Ingerslev J. PMID: 18469548.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    21. New anticoagulants in children. Hematology Am Soc Hematol Educ Program. 2008; 245-50. Young G. PMID: 19074090.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. Single 270 microg kg(-1)-dose rFVIIa vs. standard 90 microg kg(-1)-dose rFVIIa and APCC for home treatment of joint bleeds in haemophilia patients with inhibitors: a randomized comparison. Haemophilia. 2008 Mar; 14(2):287-94. Young G, Shafer FE, Rojas P, Seremetis S. PMID: 18081834.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    23. Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography. Blood Coagul Fibrinolysis. 2007 Sep; 18(6):547-53. Young G, Yonekawa KE, Nakagawa PA, Blain RC, Lovejoy AE, Nugent DJ. PMID: 17762530.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    24. Pilot dose-finding and safety study of bivalirudin in infants <6 months of age with thrombosis. J Thromb Haemost. 2007 Aug; 5(8):1654-9. Young G, Tarantino MD, Wohrley J, Weber LC, Belvedere M, Nugent DJ. PMID: 17663736.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    25. Safety and efficacy of enzyme replacement therapy in combination with hematopoietic stem cell transplantation in Hurler syndrome. Genet Med. 2005 Feb; 7(2):143-6. Grewal SS, Wynn R, Abdenur JE, Burton BK, Gharib M, Haase C, Hayashi RJ, Shenoy S, Sillence D, Tiller GE, Dudek ME, van Royen-Kerkhof A, Wraith JE, Woodard P, Young GA, Wulffraat N, Whitley CB, Peters C. PMID: 15714083.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
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