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Jorge Nieva, MD

Title(s)Associate Professor of Clinical Medicine
Phone+1 323 865 0421
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    Collapse Biography 
    Collapse Awards and Honors
    ASCO Award for Excellence in Clinical Trials
    National Cancer Institute Gold Certificate of Excellence
    Outstanding Teacher Award, Scripps Clinic
    Skaggs Scholar in Clinical Science
    Waltz Award for Leadership, Scripps Clinic
    Alpha Omega Alpha Medical Honors Society
    University of California, IrvineDepartment of Medicine Award
    Walter Blumeson Scholarship for Academic Promise
    Irving M. Reingold Prize in Pathology
    Irving M. Reingold Prize in Pathology
    American Association of Pathology Chairs Honor Society
    University of California, Irvine Excellence in Research
    University of California, IrvineDepartmental Honors, Biological Sciences

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    Collapse Overview
    Dr. Jorge Nieva graduated from the University of California, Irvine College of Medicine in 1997, trained in internal medicine at University of California, San Diego and in oncology and hematology at the Scripps Clinic. In 2003 he joined the faculty of the Scripps Research Institute and the medical staff of the Scripps Clinic in La Jolla, CA. While at Scripps, Dr. Nieva pioneered new technology for the detection of cancer cells in the peripheral blood and discoveries related to the fundamental mechanisms of the immune system.

    Dr. Nieva was recruited to the Billings Clinic in Montana in 2007 where he served as department chair and was a program leader who established the multidisciplinary lung cancer and head/neck cancer clinics at the cancer center. While in Billings, Dr. Nieva led efforts to establish a research program in virus-delivered cancer gene therapy and immunotherapy. His teams were awarded certificates for excellence in the conduct of cancer clinical trials from the National Cancer Institute and the American Society of Clinical Oncology. Dr. Nieva returned to California, joining the faculty of the Keck School of Medicine in 2014.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shishido SN, Carlsson A, Nieva J, Bethel K, Hicks JB, Bazhenova L, Kuhn P. Circulating tumor cells as a response monitor in stage IV non-small cell lung cancer. J Transl Med. 2019 Aug 28; 17(1):294. PMID: 31462312.
      View in: PubMed
    2. Horn L, Whisenant JG, Wakelee H, Reckamp KL, Qiao H, Leal TA, Du L, Hernandez J, Huang V, Blumenschein GR, Waqar SN, Patel SP, Nieva J, Oxnard GR, Sanborn RE, Shaffer T, Garg K, Holzhausen A, Harrow K, Liang C, Lim LP, Li M, Lovly CM. Monitoring therapeutic response and resistance: analysis of circulating tumor DNA in patients with ALK+ lung cancer. J Thorac Oncol. 2019 Aug 22. PMID: 31446141.
      View in: PubMed
    3. Broderick JE, May M, Schwartz JE, Li M, Mejia A, Nocera L, Kolatkar A, Ueno NT, Yennu S, Lee JSH, Hanlon SE, Cozzens Philips FA, Shahabi C, Kuhn P, Nieva J. Patient reported outcomes can improve performance status assessment: a pilot study. J Patient Rep Outcomes. 2019 Jul 16; 3(1):41. PMID: 31313047.
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    4. Ye JC, Ding L, Atay SM, Nieva JJ, McFadden PM, Chang E, Kim AW. Tri-modality versus chemoradiation and salvage resection in cN2 stage IIIA Non-Small Cell Lung Cancer. Semin Thorac Cardiovasc Surg. 2019 Jun 17. PMID: 31220530.
      View in: PubMed
    5. Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, Vanderwalde AM, Wozniak AJ, Kim ES, Liu SV. Detection of NRG1 Gene Fusions in Solid Tumors. Clin Cancer Res. 2019 Apr 15. PMID: 30988082.
      View in: PubMed
    6. Jarrell JA, Twite AA, Lau KHWJ, Kashani MN, Lievano AA, Acevedo J, Priest C, Nieva J, Gottlieb D, Pawell RS. Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding. Sci Rep. 2019 Mar 01; 9(1):3214. PMID: 30824814.
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    7. Hassani C, Varghese BA, Nieva J, Duddalwar V. Radiomics in Pulmonary Lesion Imaging. AJR Am J Roentgenol. 2019 Mar; 212(3):497-504. PMID: 30620678.
      View in: PubMed
    8. Yang SC, Welter L, Kolatkar A, Nieva J, Waitman KR, Huang KF, Liao WH, Takano S, Berelson WM, West AJ, Kuhn P, John SG. A new anion exchange purification method for Cu stable isotopes in blood samples. Anal Bioanal Chem. 2019 Jan; 411(3):765-776. PMID: 30467768.
      View in: PubMed
    9. Hasnain Z, Li M, Dorff T, Quinn D, Ueno NT, Yennu S, Kolatkar A, Shahabi C, Nocera L, Nieva J, Kuhn P, Newton PK. Low-dimensional dynamical characterization of human performance of cancer patients using motion data. Clin Biomech (Bristol, Avon). 2018 Jul; 56:61-69. PMID: 29803824.
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    10. Nieva J, Hicks J. When it comes to genomic analysis of tumours, don't buy in bulk. Br J Cancer. 2018 May; 118(10):1281-1282. PMID: 29743553.
      View in: PubMed
    11. Rodríguez-Lee M, Kolatkar A, McCormick M, Dago AD, Kendall J, Carlsson NA, Bethel K, Greenspan EJ, Hwang SE, Waitman KR, Nieva JJ, Hicks J, Kuhn P. Effect of Blood Collection Tube Type and Time to Processing on the Enumeration and High-Content Characterization of Circulating Tumor Cells Using the High-Definition Single-Cell Assay. Arch Pathol Lab Med. 2018 Feb; 142(2):198-207. PMID: 29144792.
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    12. Su DW, Nieva J. Biophysical technologies for understanding circulating tumor cell biology and metastasis. Transl Lung Cancer Res. 2017 Aug; 6(4):473-485. PMID: 28904890.
      View in: PubMed
    13. In G, Mason J, Lin S, Newton PK, Kuhn P, Nieva J. Development of metastatic brain disease involves progression through lung metastases in EGFR mutated non-small cell lung cancer. Converg Sci Phys Oncol. 2017 Sep; 3(3). PMID: 30283700.
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    14. Boffa DJ, Graf RP, Salazar MC, Hoag J, Lu D, Krupa R, Louw J, Dugan L, Wang Y, Landers M, Suraneni M, Greene SB, Magaña M, Makani S, Bazhenova L, Dittamore RV, Nieva J. Cellular Expression of PD-L1 in the Peripheral Blood of Lung Cancer Patients is Associated with Worse Survival. Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1139-1145. PMID: 28446544.
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    15. Chiappori AA, Otterson GA, Dowlati A, Traynor AM, Horn L, Owonikoko TK, Ross HJ, Hann CL, Abu Hejleh T, Nieva J, Zhao X, Schell M, Sullivan DM. A Randomized Phase II Study of Linsitinib (OSI-906) Versus Topotecan in Patients With Relapsed Small-Cell Lung Cancer. Oncologist. 2016 10; 21(10):1163-1164. PMID: 27694157.
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    16. Newton PK, Mason J, Venkatappa N, Jochelson MS, Hurt B, Nieva J, Comen E, Norton L, Kuhn P. Spatiotemporal progression of metastatic breast cancer: a Markov chain model highlighting the role of early metastatic sites. NPJ Breast Cancer. 2015; 1:15018. PMID: 28721371.
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    17. Burke J, Nieva J, Borad MJ, Breitbach CJ. Oncolytic viruses: perspectives on clinical development. Curr Opin Virol. 2015 Aug; 13:55-60. PMID: 25989094.
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    18. Gilbert J, Schell MJ, Zhao X, Murphy B, Tanvetyanon T, Leon ME, Neil Hayes D, Haigentz M, Saba N, Nieva J, Bishop J, Sidransky D, Ravi R, Bedi A, Chung CH. A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma. Oral Oncol. 2015 Apr; 51(4):376-82. PMID: 25593015.
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    19. Newton PK, Mason J, Hurt B, Bethel K, Bazhenova L, Nieva J, Kuhn P. Entropy, complexity, and Markov diagrams for random walk cancer models. Sci Rep. 2014 Dec 19; 4:7558. PMID: 25523357.
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    20. Carlsson A, Nair VS, Luttgen MS, Keu KV, Horng G, Vasanawala M, Kolatkar A, Jamali M, Iagaru AH, Kuschner W, Loo BW, Shrager JB, Bethel K, Hoh CK, Bazhenova L, Nieva J, Kuhn P, Gambhir SS. Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer. J Thorac Oncol. 2014 Aug; 9(8):1111-9. PMID: 25157764.
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    21. Bazhenova L, Newton P, Mason J, Bethel K, Nieva J, Kuhn P. Adrenal metastases in lung cancer: clinical implications of a mathematical model. J Thorac Oncol. 2014 Apr; 9(4):442-6. PMID: 24736064; PMCID: PMC3989547.
    22. Nair VS, Keu KV, Luttgen MS, Kolatkar A, Vasanawala M, Kuschner W, Bethel K, Iagaru AH, Hoh C, Shrager JB, Loo BW, Bazhenova L, Nieva J, Gambhir SS, Kuhn P. An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer. PLoS One. 2013; 8(7):e67733. PMID: 23861795.
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    23. Weickhardt AJ, Doebele RC, Purcell WT, Bunn PA, Oton AB, Rothman MS, Wierman ME, Mok T, Popat S, Bauman J, Nieva J, Novello S, Ou SH, Camidge DR. Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients. Cancer. 2013 Jul 01; 119(13):2383-90. PMID: 23585220.
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    24. Newton PK, Mason J, Bethel K, Bazhenova L, Nieva J, Norton L, Kuhn P. Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical model. Cancer Res. 2013 May 01; 73(9):2760-9. PMID: 23447576; PMCID: PMC3644026.
    25. Nieva JJ, Kuhn P. Fluid biopsy for solid tumors: a patient's companion for lifelong characterization of their disease. Future Oncol. 2012 Aug; 8(8):989-98. PMID: 22894671.
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    26. Jatoi A, Nieva JJ, Qin R, Loprinzi CL, Wos EJ, Novotny PJ, Moore DF, Mowat RB, Bechar N, Pajon ER, Hartmann LC. A pilot study of long-acting octreotide for symptomatic malignant ascites. Oncology. 2012; 82(6):315-20. PMID: 22572824.
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    27. Das M, Riess JW, Frankel P, Schwartz E, Bennis R, Hsieh HB, Liu X, Ly JC, Zhou L, Nieva JJ, Wakelee HA, Bruce RH. ERCC1 expression in circulating tumor cells (CTCs) using a novel detection platform correlates with progression-free survival (PFS) in patients with metastatic non-small-cell lung cancer (NSCLC) receiving platinum chemotherapy. Lung Cancer. 2012 Aug; 77(2):421-6. PMID: 22555222.
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    28. Newton PK, Mason J, Bethel K, Bazhenova LA, Nieva J, Kuhn P. A stochastic Markov chain model to describe lung cancer growth and metastasis. PLoS One. 2012; 7(4):e34637. PMID: 22558094; PMCID: PMC3338733.
    29. Cho EH, Wendel M, Luttgen M, Yoshioka C, Marrinucci D, Lazar D, Schram E, Nieva J, Bazhenova L, Morgan A, Ko AH, Korn WM, Kolatkar A, Bethel K, Kuhn P. Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol. 2012 Feb; 9(1):016001. PMID: 22306705; PMCID: PMC3387999.
    30. Nieva J, Wendel M, Luttgen MS, Marrinucci D, Bazhenova L, Kolatkar A, Santala R, Whittenberger B, Burke J, Torrey M, Bethel K, Kuhn P. High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis. Phys Biol. 2012 Feb; 9(1):016004. PMID: 22306961; PMCID: PMC3388002.
    31. Marrinucci D, Bethel K, Kolatkar A, Luttgen MS, Malchiodi M, Baehring F, Voigt K, Lazar D, Nieva J, Bazhenova L, Ko AH, Korn WM, Schram E, Coward M, Yang X, Metzner T, Lamy R, Honnatti M, Yoshioka C, Kunken J, Petrova Y, Sok D, Nelson D, Kuhn P. Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol. 2012 Feb; 9(1):016003. PMID: 22306768; PMCID: PMC3387996.
    32. Wendel M, Bazhenova L, Boshuizen R, Kolatkar A, Honnatti M, Cho EH, Marrinucci D, Sandhu A, Perricone A, Thistlethwaite P, Bethel K, Nieva J, Heuvel Mv, Kuhn P. Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol. 2012 Feb; 9(1):016005. PMID: 22307026; PMCID: PMC3387995.
    33. Breitbach CJ, Burke J, Jonker D, Stephenson J, Haas AR, Chow LQ, Nieva J, Hwang TH, Moon A, Patt R, Pelusio A, Le Boeuf F, Burns J, Evgin L, De Silva N, Cvancic S, Robertson T, Je JE, Lee YS, Parato K, Diallo JS, Fenster A, Daneshmand M, Bell JC, Kirn DH. Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Nature. 2011 Aug 31; 477(7362):99-102. PMID: 21886163.
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    34. Nieva J, Song BD, Rogel JK, Kujawara D, Altobel L, Izharrudin A, Boldt GE, Grover RK, Wentworth AD, Wentworth P. Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53. Chem Biol. 2011 Jul 29; 18(7):920-7. PMID: 21802012.
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    35. Marrinucci D, Bethel K, Lazar D, Fisher J, Huynh E, Clark P, Bruce R, Nieva J, Kuhn P. Cytomorphology of circulating colorectal tumor cells:a small case series. J Oncol. 2010; 2010:861341. PMID: 20111743.
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    36. Marrinucci D, Bethel K, Luttgen M, Bruce RH, Nieva J, Kuhn P. Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type. Arch Pathol Lab Med. 2009 Sep; 133(9):1468-71. PMID: 19722757.
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    37. Wentworth AD, Song BD, Nieva J, Shafton A, Tripurenani S, Wentworth P. The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo. Chem Commun (Camb). 2009 Jun 07; (21):3098-100. PMID: 19462099.
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    38. Martin FM, Prchal J, Nieva J, Saven A, Andrey J, Bethel K, Barton JC, Aripally G, Bottomley SS, Friedman JS. Purification and characterization of sideroblasts from patients with acquired and hereditary sideroblastic anaemia. Br J Haematol. 2008 Nov; 143(3):446-50. PMID: 18729851.
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    39. Nieva J, Shafton A, Altobell LJ, Tripuraneni S, Rogel JK, Wentworth AD, Lerner RA, Wentworth P. Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation. Biochemistry. 2008 Jul 22; 47(29):7695-705. PMID: 18578541.
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    40. Tilley RE, Holscher T, Belani R, Nieva J, Mackman N. Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients. Thromb Res. 2008; 122(5):604-9. PMID: 18262600.
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    41. Nieva J, Saven A. Understanding hairy cell leukemia genetics. Leuk Lymphoma. 2007 Apr; 48(4):653-4. PMID: 17454620.
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    42. Nieva J. The clinical significance of circulating tissue factor in prostate cancer. Thromb Haemost. 2007 Mar; 97(3):329-30. PMID: 17334495.
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    43. Marrinucci D, Bethel K, Bruce RH, Curry DN, Hsieh B, Humphrey M, Krivacic RT, Kroener J, Kroener L, Ladanyi A, Lazarus NH, Nieva J, Kuhn P. Case study of the morphologic variation of circulating tumor cells. Hum Pathol. 2007 Mar; 38(3):514-9. PMID: 17188328.
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    44. Bussel JB, Kuter DJ, George JN, McMillan R, Aledort LM, Conklin GT, Lichtin AE, Lyons RM, Nieva J, Wasser JS, Wiznitzer I, Kelly R, Chen CF, Nichol JL. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med. 2006 Oct 19; 355(16):1672-81. PMID: 17050891.
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    45. Nerenberg M, Kariv I, McNeeley P, Marchand P, Sur S, Diver J, Riccitelli S, Nieva J, Saven A. Use of optophoresis as an in vitro predictor of cell response to chemotherapy for chronic lymphocytic leukemia. Leuk Lymphoma. 2006 Oct; 47(10):2194-202. PMID: 17071495.
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    46. Takeuchi C, Galvé R, Nieva J, Witter DP, Wentworth AD, Troseth RP, Lerner RA, Wentworth P. Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B. Biochemistry. 2006 Jun 13; 45(23):7162-70. PMID: 16752907.
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    47. Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem Biol. 2006 May; 2(5):249-53. PMID: 16565714.
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    48. Hsieh HB, Marrinucci D, Bethel K, Curry DN, Humphrey M, Krivacic RT, Kroener J, Kroener L, Ladanyi A, Lazarus N, Kuhn P, Bruce RH, Nieva J. High speed detection of circulating tumor cells. Biosens Bioelectron. 2006 Apr 15; 21(10):1893-9. PMID: 16464570.
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    49. Nieva J, Kerwin L, Wentworth AD, Lerner RA, Wentworth P. Immunoglobulins can utilize riboflavin (Vitamin B2) to activate the antibody-catalyzed water oxidation pathway. Immunol Lett. 2006 Feb 28; 103(1):33-8. PMID: 16386801.
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    50. Mena-Duran AV, Togo SH, Bazhenova L, Cervera J, Bethel K, Senent ML, Nieva J, Sanz GF, Sanz MA, Saven A, Mustelin T. SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor. Br J Haematol. 2005 Jun; 129(6):791-4. PMID: 15953006.
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    51. Nieva J, Wentworth P. The antibody-catalyzed water oxidation pathway--a new chemical arm to immune defense? Trends Biochem Sci. 2004 May; 29(5):274-8. PMID: 15130564.
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    52. Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4752-7. PMID: 15034169.
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    53. Nieva J, Saven A. Cladribine activity in systemic mast cell disease: application of biochemistry in the modern era of molecular biology. Leuk Res. 2004 Feb; 28(2):113-4. PMID: 14654073.
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    54. Wentworth P, Nieva J, Takeuchi C, Galve R, Wentworth AD, Dilley RB, DeLaria GA, Saven A, Babior BM, Janda KD, Eschenmoser A, Lerner RA. Evidence for ozone formation in human atherosclerotic arteries. Science. 2003 Nov 07; 302(5647):1053-6. PMID: 14605372.
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    55. Nieva J, Bethel K, Saven A. Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia. Blood. 2003 Aug 01; 102(3):810-3. PMID: 12663446.
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    56. Wentworth P, McDunn JE, Wentworth AD, Takeuchi C, Nieva J, Jones T, Bautista C, Ruedi JM, Gutierrez A, Janda KD, Babior BM, Eschenmoser A, Lerner RA. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science. 2002 Dec 13; 298(5601):2195-9. PMID: 12434011.
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    57. Stuart MJ, Smith AM, Nieva JJ, Rock MG. Injuries in youth ice hockey: a pilot surveillance strategy. Mayo Clin Proc. 1995 Apr; 70(4):350-6. PMID: 7898141.
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