Ite A. Offringa, PhD

Title(s)Associate Professor of Surgery
SchoolKeck School of Medicine of Usc
Health Sciences Campus
Los Angeles CA 90089-9176
Phone+1 323 865 0655
ORCID ORCID Icon0000-0001-5729-6488 Additional info
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    Other Positions
    Title(s)Associate Dean for Graduate Affairs (Ph.D. Programs)

    Collapse Biography 
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    University of Leiden, The NetherlandsBS, MS1985Molecular Biology
    University of Leiden, The NetherlandsPhD1991Medical Biochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Offringa is Associate Professor of Surgery and of Biochemistry & Molecular Medicine at USC Keck School of Medicine. She received her Ph.D. in 1991 from University of Leiden (the Netherlands), and she undertook a postdoctoral research fellowship from 1991–1996 at Harvard Medical School (Boston, MA). She joined the USC faculty in 1996. Research in the Offringa laboratory is/has been funded by the National Institutes of Health, American Lung Association, the Wright Foundation, the Whittier Translational Research Fund, the Mesothelioma Applied Research Foundation, Joan's Legacy, the Department of Defense, the Tobacco-Related Disease Research Fund, the Thomas G Labrecque Foundation, the V Foundation, the Canary Foundation, the Kazan Foundation, the Hoag Family Foundation, the California Community Foundation, STOP Cancer, and private donations from many generous individuals, including the Mettler family, Wally and Conya Pembroke, Michelle and Paul Zygielbaum, Steven Schwartz, Sharon Binder, Bonnie and Tony Addario, Larry Auerbach, Judy Glick, and others.

    The Offringa lab studies the cancer that kills the most Americans every year (over 125,000 people per year, almost one Boeing 747 of people per day!). More people die of lung cancer than from breast, prostate, and colon cancer combined. The high death rate is largely the result of detecting this cancer too late.

    On the one hand, the Offringa lab focuses on lung adenocarcinoma (LUAD), the most common histological type of lung cancer. It arises in the alveoli or air sacs, which make up 90% of the lung surface and, for one adult, constitute a surface the size of half a tennis court. The alveolar epithelium is thus inordinately exposed to airborne environmental carcinogens and viruses. We study global gene expression in primary LUAD samples and cell lines, the epigenetic basis of normal alveolar lung development, the effects of the environment on the lung epigenome, the interplay between the genome and the epigenome, and single cell transcriptomics.
    We are also studying the role of single nucleotide polymorphisms in lung cancer predisposition; one aspect of early detection is risk classification. Understanding how genetic differences between individuals influences cancer risk will help identify the subjects at highest risk, for whom it is even more important that they should be screened.

    Another area of focus of the Offringa lab is small cell lung cancer (SCLC), the most aggressive type of lung cancer. SCLC rapidly metastasizes and patients have an average 5-year survival of just 8%. We are analyzing patients' anti-cancer immune responses to see how these could be leveraged for targeted immunotherapy.

    Lastly, we are interested in protein engineering and biomolecular interactions, which are key to the development of new drugs and therapies. The Offringa lab oversees the Norris Comprehensive Cancer Center's SwitchSENSE DRX2 Biosensor, which is used to analyze biomolecular interactions.

    Collapse Research 
    Collapse Research Activities and Funding
    Epigenetic profiling of human alveolar epithelial cells in health and disease
    NIH R01HL114094Sep 23, 2011 - Jun 30, 2017
    Role: Principal Investigator
    DNA Methylation Changes During Development and Progression of Lung Adenocarcinoma
    NIH R01CA120869Jul 1, 2007 - May 31, 2013
    Role: Co-Principal Investigator
    Development of DNA Methylation Markers for Early Detection of Lung Cancer
    NIH R01CA119029Sep 1, 2006 - Jul 31, 2012
    Role: Co-Principal Investigator
    Lung Cancer Diagnosis Using DNA Methylation Signatures
    NIH R21CA102247Sep 1, 2003 - Aug 31, 2006
    Role: Co-Principal Investigator
    NIH R29CA078407Jul 10, 1998 - Jun 30, 2003
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mentoring Minority Cancer Researchers of Tomorrow: Comparison of the Face-to-Face, Virtual, and Hybrid Training Methods of the CaRE2 Summer Cancer Research Education and Training Program. J Cancer Educ. 2024 Mar 23. Mochona B, Redda KK, Offringa IA, Allen J, Carpten JD, Stern MC, Reams RR, Wilkie DJ. PMID: 38520478.
      View in: PubMed   Mentions:    Fields:    
    2. Lack of racial and ethnic diversity in lung cancer cell lines contributes to lung cancer health disparities. Front Oncol. 2023; 13:1187585. Leon C, Manley E, Neely AM, Castillo J, Ramos Correa M, Velarde DA, Yang M, Puente PE, Romero DI, Ren B, Chai W, Gladstone M, Lamango NS, Huang Y, Offringa IA. PMID: 38023251; PMCID: PMC10651223.
      View in: PubMed   Mentions: 1  
    3. Bio-Design and Manufacturing. Design and realization of lung organoid cultures for COVID-19 applications. 2023. Bing Ren1 · Tryanni R. Chiaravalloti2 · Nadine L. Belony3 · Diana I. Romero3 · Wenxuan Chai1 · Christopher Leon4 · Lizi Wu5 · Nazarius S. Lamango6 · Ite A. Offringa4 · Yong Huang1, 2. View Publication.
    4. Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes. Cancer Control. 2023 Jan-Dec; 30:10732748231197878. Reams RR, Odedina FT, Carpten JD, Redda K, Stern MC, Krieger JL, Aparicio J, Hensel B, Askins N, Abreu A, Adams A, Agyare E, Ali J, Allen JM, Aló R, Baezconde-Garbanati L, Brant J, Brown CP, Buxbaum SG, Cohen P, Cozen W, Ezenwa MO, Falzarano S, Fillingim RB, Flores-Rozas H, Fredenburg KM, George T, Han B, Huang Y, Hughes Halbert C, Kiros GE, Lamango NS, Lee JH, Lyon DE, Mitchell DA, Mochona B, Nieva JJ, Offringa IA, Okunieff P, Parker A, Rhie SK, Richey JM, Rogers SC, Salhia B, Schmittgen TD, Segal R, Setiawan VW, Smith U, Su LM, Suther S, Trevino J, Velazquez-Villarreal EI, Webb FJ, Wu AH, Yao Y, Wilkie DJ. PMID: 37703814; PMCID: PMC10501072.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Development of human alveolar epithelial cell models to study distal lung biology and disease. iScience. 2022 Feb 18; 25(2):103780. Tran E, Shi T, Li X, Chowdhury AY, Jiang D, Liu Y, Wang H, Yan C, Wallace WD, Lu R, Ryan AL, Marconett CN, Zhou B, Borok Z, Offringa IA. PMID: 35169685; PMCID: PMC8829779.
      View in: PubMed   Mentions: 11  
    6. The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma. Int J Environ Res Public Health. 2021 12 31; 19(1). Johnson C, Mullen DJ, Selamat SA, Campan M, Offringa IA, Marconett CN. PMID: 35010676; PMCID: PMC8744592.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity. BMC Genomics. 2021 Dec 18; 22(1):906. Zhou B, Stueve TR, Mihalakakos EA, Miao L, Mullen D, Wang Y, Liu Y, Luo J, Tran E, Siegmund KD, Lynch SK, Ryan AL, Offringa IA, Borok Z, Marconett CN. PMID: 34922464; PMCID: PMC8684104.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. Developing a Novel Framework for an Undergraduate Cancer Research Education and Engagement Program for Underrepresented Minority Students: the Florida-California CaRE2 Research Education Core (REC) Training Program. J Cancer Educ. 2021 10; 36(5):914-919. Mochona B, Lyon D, Offringa IA, Redda KK, Reams RR, Odedina F, Wilkie DJ, Stern MC, Carpten JD. PMID: 32430639; PMCID: PMC7674268.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis. Oncogene. 2021 05; 40(20):3624-3632. Rangel DF, Dubeau L, Park R, Chan P, Ha DP, Pulido MA, Mullen DJ, Vorobyova I, Zhou B, Borok Z, Offringa IA, Lee AS. PMID: 33931739; PMCID: PMC8179725.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    10. Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker. Cells. 2020 11 11; 9(11). Horie M, Castaldi A, Sunohara M, Wang H, Ji Y, Liu Y, Li F, Wilkinson TA, Hung L, Shen H, Kage H, Offringa IA, Marconett CN, Flodby P, Zhou B, Borok Z. PMID: 33187367; PMCID: PMC7697677.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PLoS Genet. 2020 09; 16(9):e1009023. Mullen DJ, Yan C, Kang DS, Zhou B, Borok Z, Marconett CN, Farnham PJ, Offringa IA, Rhie SK. PMID: 32925947; PMCID: PMC7515200.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2020 07 01; 319(1):L173-L184. Castaldi A, Horie M, Rieger ME, Dubourd M, Sunohara M, Pandit K, Zhou B, Offringa IA, Marconett CN, Borok Z. PMID: 32432919; PMCID: PMC7468844.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. Luo J, Chimge NO, Zhou B, Flodby P, Castaldi A, Firth AL, Liu Y, Wang H, Yang C, Marconett CN, Crandall ED, Offringa IA, Frenkel B, Borok Z. PMID: 30325015; PMCID: PMC6263834.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes. Epigenomics. 2018 09; 10(9):1167-1187. Yang C, Stueve TR, Yan C, Rhie SK, Mullen DJ, Luo J, Zhou B, Borok Z, Marconett CN, Offringa IA. PMID: 30212242; PMCID: PMC6391636.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clin Epigenetics. 2018 08 23; 10(1):110. Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L. PMID: 30139389; PMCID: PMC6108111.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    16. Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes. Am J Respir Cell Mol Biol. 2017 03; 56(3):310-321. Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z. PMID: 27749084; PMCID: PMC5359537.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    17. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet. 2017 01 15; 26(2):454-465. Seow WJ, Matsuo K, Hsiung CA, Shiraishi K, Song M, Kim HN, Wong MP, Hong YC, Hosgood HD, Wang Z, Chang IS, Wang JC, Chatterjee N, Tucker M, Wei H, Mitsudomi T, Zheng W, Kim JH, Zhou B, Caporaso NE, Albanes D, Shin MH, Chung LP, An SJ, Wang P, Zheng H, Yatabe Y, Zhang XC, Kim YT, Shu XO, Kim YC, Bassig BA, Chang J, Ho JC, Ji BT, Kubo M, Daigo Y, Ito H, Momozawa Y, Ashikawa K, Kamatani Y, Honda T, Sakamoto H, Kunitoh H, Tsuta K, Watanabe SI, Nokihara H, Miyagi Y, Nakayama H, Matsumoto S, Tsuboi M, Goto K, Yin Z, Shi J, Takahashi A, Goto A, Minamiya Y, Shimizu K, Tanaka K, Wu T, Wei F, Wong JY, Matsuda F, Su J, Kim YH, Oh IJ, Song F, Lee VH, Su WC, Chen YM, Chang GC, Chen KY, Huang MS, Yang PC, Lin HC, Xiang YB, Seow A, Park JY, Kweon SS, Chen CJ, Li H, Gao YT, Wu C, Qian B, Lu D, Liu J, Jeon HS, Hsiao CF, Sung JS, Tsai YH, Jung YJ, Guo H, Hu Z, Wang WC, Chung CC, Lawrence C, Burdett L, Yeager M, Jacobs KB, Hutchinson A, Berndt SI, He X, Wu W, Wang J, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Hu L, Chen CH, Yang TY, Xu J, Guan P, Tan W, Wang CL, Sihoe AD, Chen Y, Choi YY, Hung JY, Kim JS, Yoon HI, Cai Q, Lin CC, Park IK, Xu P, Dong J, Kim C, He Q, Perng RP, Chen CY, Vermeulen R, Wu J, Lim WY, Chen KC, Chan JK, Chu M, Li YJ, Li J, Chen H, Yu CJ, Jin L, Lo YL, Chen YH, Fraumeni JF, Liu J, Yamaji T, Yang Y, Hicks B, Wyatt K, Li SA, Dai J, Ma H, Jin G, Song B, Wang Z, Cheng S, Li X, Ren Y, Cui P, Iwasaki M, Shimazu T, Tsugane S, Zhu J, Jiang G, Fei K, Wu G, Chien LH, Chen HL, Su YC, Tsai FY, Chen YS, Yu J, Stevens VL, Laird-Offringa IA, Marconett CN, Lin D, Chen K, Wu YL, Landi MT, Shen H, Rothman N, Kohno T, Chanock SJ, Lan Q. PMID: 28025329; PMCID: PMC5856088.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    18. Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study. PLoS Med. 2016 Dec; 13(12):e1002162. Shi J, Hua X, Zhu B, Ravichandran S, Wang M, Nguyen C, Brodie SA, Palleschi A, Alloisio M, Pariscenti G, Jones K, Zhou W, Bouk AJ, Boland J, Hicks B, Risch A, Bennett H, Luke BT, Song L, Duan J, Liu P, Kohno T, Chen Q, Meerzaman D, Marconett C, Laird-Offringa I, Mills I, Caporaso NE, Gail MH, Pesatori AC, Consonni D, Bertazzi PA, Chanock SJ, Landi MT. PMID: 27923066; PMCID: PMC5140047.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    19. Data on isoaspartylation of neuronal ELAVL proteins. Data Brief. 2016 Dec; 9:1052-1055. Pulido MA, DerHartunian MK, Sehgal P, Laird-Offringa IA. . PMID: 27924291; PMCID: PMC5128017.
      View in: PubMed   Mentions: 1  
    20. Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. J Neuroimmunol. 2016 10 15; 299:70-78. Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJGM, Aswad DW, Laird-Offringa IA. . PMID: 27725125; PMCID: PMC5152694.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. J Natl Cancer Inst. 2016 12; 108(12). Zuber V, Marconett CN, Shi J, Hua X, Wheeler W, Yang C, Song L, Dale AM, Laplana M, Risch A, Witoelar A, Thompson WK, Schork AJ, Bettella F, Wang Y, Djurovic S, Zhou B, Borok Z, van der Heijden HF, de Graaf J, Swinkels D, Aben KK, McKay J, Hung RJ, Bikeböller H, Stevens VL, Albanes D, Caporaso NE, Han Y, Wei Y, Panadero MA, Mayordomo JI, Christiani DC, Kiemeney L, Andreassen OA, Houlston R, Amos CI, Chatterjee N, Laird-Offringa IA, Mills IG, Landi MT. PMID: 27565901; PMCID: PMC5241892.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    22. The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. Am J Respir Cell Mol Biol. 2016 07; 55(1):135-49. Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B. PMID: 26816051; PMCID: PMC4942208.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    23. The importance of detailed epigenomic profiling of different cell types within organs. Epigenomics. 2016 06; 8(6):817-29. Stueve TR, Marconett CN, Zhou B, Borok Z, Laird-Offringa IA. . PMID: 27305639; PMCID: PMC5066118.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    24. An Evolved RNA Recognition Motif That Suppresses HIV-1 Tat/TAR-Dependent Transcription. ACS Chem Biol. 2016 08 19; 11(8):2206-15. Crawford DW, Blakeley BD, Chen PH, Sherpa C, Le Grice SF, Laird-Offringa IA, McNaughton BR. PMID: 27253715; PMCID: PMC5199234.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    25. Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. Liebler JM, Marconett CN, Juul N, Wang H, Liu Y, Flodby P, Laird-Offringa IA, Minoo P, Zhou B. PMID: 26545903; PMCID: PMC4719049.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    26. Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival. Cancer Res. 2015 May 01; 75(9):1789-800. Schliekelman MJ, Taguchi A, Zhu J, Dai X, Rodriguez J, Celiktas M, Zhang Q, Chin A, Wong CH, Wang H, McFerrin L, Selamat SA, Yang C, Kroh EM, Garg KS, Behrens C, Gazdar AF, Laird-Offringa IA, Tewari M, Wistuba II, Thiery JP, Hanash SM. PMID: 25744723; PMCID: PMC4846295.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    27. Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat. Genom Data. 2014 Dec 01; 2:105-109. Marconett CN, Zhou B, Siegmund KD, Borok Z, Laird-Offringa IA. . PMID: 25343132; PMCID: PMC4203668.
      View in: PubMed   Mentions: 5  
    28. Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. PMID: 24588076; PMCID: PMC4148039.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    29. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun. 2014 Feb 27; 5:3365. Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Freedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT. PMID: 24572595; PMCID: PMC3982882.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    30. CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer. J Thorac Oncol. 2013 Nov; 8(11):1378-88. Tam KW, Zhang W, Soh J, Stastny V, Chen M, Sun H, Thu K, Rios JJ, Yang C, Marconett CN, Selamat SA, Laird-Offringa IA, Taguchi A, Hanash S, Shames D, Ma X, Zhang MQ, Lam WL, Gazdar A. PMID: 24077454; PMCID: PMC3951422.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    31. EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene. 2014 Sep 04; 33(36):4464-73. Wilson IM, Vucic EA, Enfield KS, Thu KL, Zhang YA, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banáth JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TP, Selamat SA, Laird-Offringa IA, Liu P, Anderson M, You M, Tsao MS, Brown CJ, Bennewith KL, MacAulay CE, Karsan A, Gazdar AF, Lam S, Lam WL. PMID: 24096489; PMCID: PMC4527534.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    32. Analysis of protein-RNA complexes involving a RNA recognition motif engineered to bind hairpins with seven- and eight-nucleotide loops. Biochemistry. 2013 Jul 16; 52(28):4745-7. Blakeley BD, Shattuck J, Coates MB, Tran E, Laird-Offringa IA, McNaughton BR. PMID: 23806102.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    33. Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet. 2013 Jun; 9(6):e1003513. Marconett CN, Zhou B, Rieger ME, Selamat SA, Dubourd M, Fang X, Lynch SK, Stueve TR, Siegmund KD, Berman BP, Borok Z, Laird-Offringa IA. . PMID: 23818859; PMCID: PMC3688557.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    34. Epigenetic therapy in lung cancer. Front Oncol. 2013; 3:135. Liu SV, Fabbri M, Gitlitz BJ, Laird-Offringa IA. . PMID: 23755372; PMCID: PMC3667274.
      View in: PubMed   Mentions: 16  
    35. The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA. Nucleic Acids Res. 2013 Aug; 41(14):7092-100. Law MJ, Lee DS, Lee CS, Anglim PP, Haworth IS, Laird-Offringa IA. . PMID: 23703211; PMCID: PMC3737524.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    36. DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. Cell Rep. 2012 Nov 29; 2(5):1197-206. Chen Y, Bates DL, Dey R, Chen PH, Machado AC, Laird-Offringa IA, Rohs R, Chen L. PMID: 23142663; PMCID: PMC3978094.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    37. Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res. 2012 Jul; 22(7):1197-211. Selamat SA, Chung BS, Girard L, Zhang W, Zhang Y, Campan M, Siegmund KD, Koss MN, Hagen JA, Lam WL, Lam S, Gazdar AF, Laird-Offringa IA. . PMID: 22613842; PMCID: PMC3396362.
      View in: PubMed   Mentions: 317     Fields:    Translation:HumansCells
    38. Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. PLoS One. 2011; 6(12):e28141. Campan M, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, Dubeau L, Siegmund KD, Wu AH, Groshen S, Chandavarkar U, Roman LD, Berchuck A, Pearce CL, Laird PW. PMID: 22163280; PMCID: PMC3233546.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    39. DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PLoS One. 2011; 6(6):e21443. Selamat SA, Galler JS, Joshi AD, Fyfe MN, Campan M, Siegmund KD, Kerr KM, Laird-Offringa IA. . PMID: 21731750; PMCID: PMC3121768.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    40. Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy. Mol Cancer. 2011 Mar 30; 10:33. Kazarian M, Laird-Offringa IA. . PMID: 21450098; PMCID: PMC3080347.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    41. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology. 2010 May; 138(5):1943-53. Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballería J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martínez-Chantar ML. PMID: 20102719; PMCID: PMC2860011.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    42. Immune response in lung cancer mouse model mimics human anti-Hu reactivity. J Neuroimmunol. 2009 Dec 10; 217(1-2):38-45. Kazarian M, Calbo J, Proost N, Carpenter CL, Berns A, Laird-Offringa IA. . PMID: 19765830; PMCID: PMC2788043.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    43. Low level anti-Hu reactivity: A risk marker for small cell lung cancer? Cancer Detect Prev. 2009; 32(4):292-9. Tsou JA, Kazarian M, Patel A, Galler JS, Laird-Offringa IA, Carpenter CL, London SJ. PMID: 19070439; PMCID: PMC2952929.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    44. A global benchmark study using affinity-based biosensors. Anal Biochem. 2009 Mar 15; 386(2):194-216. Rich RL, Papalia GA, Flynn PJ, Furneisen J, Quinn J, Klein JS, Katsamba PS, Waddell MB, Scott M, Thompson J, Berlier J, Corry S, Baltzinger M, Zeder-Lutz G, Schoenemann A, Clabbers A, Wieckowski S, Murphy MM, Page P, Ryan TE, Duffner J, Ganguly T, Corbin J, Gautam S, Anderluh G, Bavdek A, Reichmann D, Yadav SP, Hommema E, Pol E, Drake A, Klakamp S, Chapman T, Kernaghan D, Miller K, Schuman J, Lindquist K, Herlihy K, Murphy MB, Bohnsack R, Andrien B, Brandani P, Terwey D, Millican R, Darling RJ, Wang L, Carter Q, Dotzlaf J, Lopez-Sagaseta J, Campbell I, Torreri P, Hoos S, England P, Liu Y, Abdiche Y, Malashock D, Pinkerton A, Wong M, Lafer E, Hinck C, Thompson K, Primo CD, Joyce A, Brooks J, Torta F, Bagge Hagel AB, Krarup J, Pass J, Ferreira M, Shikov S, Mikolajczyk M, Abe Y, Barbato G, Giannetti AM, Krishnamoorthy G, Beusink B, Satpaev D, Tsang T, Fang E, Partridge J, Brohawn S, Horn J, Pritsch O, Obal G, Nilapwar S, Busby B, Gutierrez-Sanchez G, Gupta RD, Canepa S, Witte K, Nikolovska-Coleska Z, Cho YH, D'Agata R, Schlick K, Calvert R, Munoz EM, Hernaiz MJ, Bravman T, Dines M, Yang MH, Puskas A, Boni E, Li J, Wear M, Grinberg A, Baardsnes J, Dolezal O, Gainey M, Anderson H, Peng J, Lewis M, Spies P, Trinh Q, Bibikov S, Raymond J, Yousef M, Chandrasekaran V, Feng Y, Emerick A, Mundodo S, Guimaraes R, McGirr K, Li YJ, Hughes H, Mantz H, Skrabana R, Witmer M, Ballard J, Martin L, Skladal P, Korza G, Laird-Offringa I, Lee CS, Khadir A, Podlaski F, Neuner P, Rothacker J, Rafique A, Dankbar N, Kainz P, Gedig E, Vuyisich M, Boozer C, Ly N, Toews M, Uren A, Kalyuzhniy O, Lewis K, Chomey E, Pak BJ, Myszka DG. PMID: 19133223; PMCID: PMC3793259.
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    45. DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update. Mol Cancer. 2008 Oct 23; 7:81. Anglim PP, Alonzo TA, Laird-Offringa IA. . PMID: 18947422; PMCID: PMC2585582.
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    46. Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer. 2008 Jul 10; 7:62. Anglim PP, Galler JS, Koss MN, Hagen JA, Turla S, Campan M, Weisenberger DJ, Laird PW, Siegmund KD, Laird-Offringa IA. . PMID: 18616821; PMCID: PMC2483990.
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    47. Conformationally restricted nucleotides as a probe of structure-function relationships in RNA. RNA. 2008 Aug; 14(8):1632-43. Julien KR, Sumita M, Chen PH, Laird-Offringa IA, Hoogstraten CG. PMID: 18596252; PMCID: PMC2491483.
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    48. Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer. 2007 Oct 29; 6:70. Tsou JA, Galler JS, Siegmund KD, Laird PW, Turla S, Cozen W, Hagen JA, Koss MN, Laird-Offringa IA. . PMID: 17967182; PMCID: PMC2206053.
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    49. DNA methylation profile of 28 potential marker loci in malignant mesothelioma. Lung Cancer. 2007 Nov; 58(2):220-30. Tsou JA, Galler JS, Wali A, Ye W, Siegmund KD, Groshen S, Laird PW, Turla S, Koss MN, Pass HI, Laird-Offringa IA. . PMID: 17659810; PMCID: PMC2752414.
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    50. The role of DNA methylation in the development and progression of lung adenocarcinoma. Dis Markers. 2007; 23(1-2):5-30. Kerr KM, Galler JS, Hagen JA, Laird PW, Laird-Offringa IA. . PMID: 17325423; PMCID: PMC3851711.
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    51. The role of RNA structure in the interaction of U1A protein with U1 hairpin II RNA. RNA. 2006 Jul; 12(7):1168-78. Law MJ, Rice AJ, Lin P, Laird-Offringa IA. . PMID: 16738410; PMCID: PMC1484440.
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    52. Kinetic analysis of a high-affinity antibody/antigen interaction performed by multiple Biacore users. Anal Biochem. 2006 May 15; 352(2):208-21. Katsamba PS, Navratilova I, Calderon-Cacia M, Fan L, Thornton K, Zhu M, Bos TV, Forte C, Friend D, Laird-Offringa I, Tavares G, Whatley J, Shi E, Widom A, Lindquist KC, Klakamp S, Drake A, Bohmann D, Roell M, Rose L, Dorocke J, Roth B, Luginbühl B, Myszka DG. PMID: 16564019.
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    53. The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA. Nucleic Acids Res. 2006; 34(1):275-85. Law MJ, Linde ME, Chambers EJ, Oubridge C, Katsamba PS, Nilsson L, Haworth IS, Laird-Offringa IA. . PMID: 16407334; PMCID: PMC1326249.
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    54. Kinetic analysis of the role of the tyrosine 13, phenylalanine 56 and glutamine 54 network in the U1A/U1 hairpin II interaction. Nucleic Acids Res. 2005; 33(9):2917-28. Law MJ, Chambers EJ, Katsamba PS, Haworth IS, Laird-Offringa IA. . PMID: 15914668; PMCID: PMC1140079.
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    55. Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung. Lung Cancer. 2005 Feb; 47(2):193-204. Tsou JA, Shen LY, Siegmund KD, Long TI, Laird PW, Seneviratne CK, Koss MN, Pass HI, Hagen JA, Laird-Offringa IA. . PMID: 15639718.
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    56. Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target. J Mol Biol. 2004 Apr 02; 337(4):799-816. Johansson C, Finger LD, Trantirek L, Mueller TD, Kim S, Laird-Offringa IA, Feigon J. PMID: 15033352.
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    57. A comparison of cluster analysis methods using DNA methylation data. Bioinformatics. 2004 Aug 12; 20(12):1896-904. Siegmund KD, Laird PW, Laird-Offringa IA. . PMID: 15044245.
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    58. Classification of individual lung cancer cell lines based on DNA methylation markers: use of linear discriminant analysis and artificial neural networks. J Mol Diagn. 2004 Feb; 6(1):28-36. Marchevsky AM, Tsou JA, Laird-Offringa IA. . PMID: 14736824; PMCID: PMC1867460.
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    59. Characterization of the interaction between neuronal RNA-binding protein HuD and AU-rich RNA. J Biol Chem. 2003 Oct 10; 278(41):39801-8. Park-Lee S, Kim S, Laird-Offringa IA. . PMID: 12900401.
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    60. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem. 2002 Nov 22; 277(47):44623-30. Li H, Park S, Kilburn B, Jelinek MA, Henschen-Edman A, Aswad DW, Stallcup MR, Laird-Offringa IA. . PMID: 12237300.
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    61. DNA methylation analysis: a powerful new tool for lung cancer diagnosis. Oncogene. 2002 Aug 12; 21(35):5450-61. Tsou JA, Hagen JA, Carpenter CL, Laird-Offringa IA. . PMID: 12154407.
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    62. Complex role of the beta 2-beta 3 loop in the interaction of U1A with U1 hairpin II RNA. J Biol Chem. 2002 Sep 06; 277(36):33267-74. Katsamba PS, Bayramyan M, Haworth IS, Myszka DG, Laird-Offringa IA. . PMID: 12082087.
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    63. Hierarchical clustering of lung cancer cell lines using DNA methylation markers. Cancer Epidemiol Biomarkers Prev. 2002 Mar; 11(3):291-7. Virmani AK, Tsou JA, Siegmund KD, Shen LY, Long TI, Laird PW, Gazdar AF, Laird-Offringa IA. . PMID: 11895880.
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    64. Kinetic studies of RNA-protein interactions using surface plasmon resonance. Methods. 2002 Feb; 26(2):95-104. Katsamba PS, Park S, Laird-Offringa IA. . PMID: 12054886.
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    65. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA. J Biol Chem. 2001 Jun 15; 276(24):21476-81. Katsamba PS, Myszka DG, Laird-Offringa IA. . PMID: 11297556.
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    66. Post-transcriptional deregulation of myc genes in lung cancer cell lines. Am J Respir Cell Mol Biol. 2000 Oct; 23(4):560-5. Bernasconi NL, Wormhoudt TA, Laird-Offringa IA. . PMID: 11017923.
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    67. HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA. Mol Cell Biol. 2000 Jul; 20(13):4765-72. Park S, Myszka DG, Yu M, Littler SJ, Laird-Offringa IA. . PMID: 10848602; PMCID: PMC85909.
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    68. In vitro genetic analysis of RNA-binding proteins using phage display. Methods Mol Biol. 1999; 118:189-216. Laird-Offringa IA. . PMID: 10549524.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    69. RNA-binding proteins tamed. Nat Struct Biol. 1998 Aug; 5(8):665-8. Laird-Offringa IA, Belasco JG. PMID: 9699622.
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    70. In vitro genetic analysis of RNA-binding proteins using phage display libraries. Methods Enzymol. 1996; 267:149-68. Laird-Offringa IA, Belasco JG. PMID: 8743315.
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    71. Analysis of RNA-binding proteins by in vitro genetic selection: identification of an amino acid residue important for locking U1A onto its RNA target. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11859-63. Laird-Offringa IA, Belasco JG. PMID: 8524863; PMCID: PMC40502.
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    72. What determines the instability of c-myc proto-oncogene mRNA? Bioessays. 1992 Feb; 14(2):119-24. Laird-Offringa IA. . PMID: 1575711.
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    73. Rapid c-myc mRNA degradation does not require (A + U)-rich sequences or complete translation of the mRNA. Nucleic Acids Res. 1991 May 11; 19(9):2387-94. Laird-Offringa IA, Elfferich P, van der Eb AJ. PMID: 1645870; PMCID: PMC329447.
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    74. Poly(A) tail shortening is the translation-dependent step in c-myc mRNA degradation. Mol Cell Biol. 1990 Dec; 10(12):6132-40. Laird-Offringa IA, de Wit CL, Elfferich P, van der Eb AJ. PMID: 1701014; PMCID: PMC362888.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    75. Analysis of polyadenylation site usage of the c-myc oncogene. Nucleic Acids Res. 1989 Aug 25; 17(16):6499-514. Laird-Offringa IA, Elfferich P, Knaken HJ, de Ruiter J, van der Eb AJ. PMID: 2674898; PMCID: PMC318344.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    76. Complementation of Agrobacterium tumefaciens tumor-inducing aux mutants by genes from the T(R)-region of the Ri plasmid of Agrobacterium rhizogenes. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6935-9. Offringa IA, Melchers LS, Regensburg-Tuink AJ, Costantino P, Schilperoort RA, Hooykaas PJ. PMID: 16593762; PMCID: PMC386625.
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