Omid Akbari, PhD

Title(s)Professor of Molecular Microbiology & Immunology
SchoolKeck School of Medicine of Usc
AddressNRT 5505 1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 7930
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Study the link of autophagy dysfunction to allergic and neutrophilic asthma onset
    NIH R01HL151493Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Induction of cells and pathways that promote respiratory tolerance in allergic asthma
    NIH R01HL144790Sep 1, 2019 - Aug 31, 2023
    Role: Principal Investigator
    Maternal effect on offspring immunity against hepatitis B virus
    NIH R01AI145813Jul 3, 2019 - Jun 30, 2024
    Role: Co-Principal Investigator
    Role of Microbiome Sodium Butyrate in regulation of ILC2 dependent airway hyperreactivity
    NIH R21AI132084May 18, 2017 - Apr 30, 2020
    Role: Principal Investigator
    The function of CRAC channels in airway inflammation
    NIH R21AI109059Jan 1, 2016 - Dec 31, 2017
    Role: Co-Principal Investigator
    Genetic and Environmental Determinants of Asthma Endophenotypes
    NIH R01ES025786Aug 1, 2015 - Apr 30, 2021
    Role: Co-Principal Investigator
    Air pollution, immune modulation of adipose tissue and type-2 diabetes risk factors
    NIH R21ES024707Jul 10, 2014 - Jun 30, 2018
    Role: Co-Principal Investigator
    INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMA
    NIH R01ES021801Aug 1, 2012 - Oct 31, 2019
    Role: Co-Principal Investigator
    Role of NKT cells in airway hyperreactivity &tolerance
    NIH R01AI066020Sep 20, 2007 - Aug 31, 2014
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models. Nat Commun. 2023 Sep 26; 14(1):5989. Howard E, Hurrell BP, Helou DG, Shafiei-Jahani P, Hasiakos S, Painter J, Srikanth S, Gwack Y, Akbari O. PMID: 37752127; PMCID: PMC10522697.
      View in: PubMed   Mentions:    Fields:    
    2. Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct. BMJ Open. 2023 09 22; 13(9):e072098. Hempel S, Danz M, Robinson KA, Bolshakova M, Rodriguez J, Mears A, Pham C, Yagyu S, Motala A, Tolentino D, Akbari O, Johnston J. PMID: 37739463; PMCID: PMC10533706.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    3. LAIR-1 limits macrophage activation in acute inflammatory lung injury. Mucosal Immunol. 2023 09 09. Helou DG, Quach C, Hurrell BP, Li X, Li M, Akbari A, Shen S, Shafiei-Jahani P, Akbari O. PMID: 37634572.
      View in: PubMed   Mentions:    Fields:    
    4. Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome. Cell Rep. 2023 08 29; 42(8):112990. Quach C, Helou DG, Li M, Hurrell BP, Howard E, Shafiei-Jahani P, Soroosh P, Ou JJ, Razani B, Rehan V, Akbari O. PMID: 37590140; PMCID: PMC10510741.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection. Res Sq. 2023 Jul 03. Barbetta A, Rocque B, Bangerth S, Street K, Weaver C, Chopra S, Kim J, Sher L, Gaudilliere B, Akbari O, Kohli R, Emamaullee J. PMID: 37461437; PMCID: PMC10350170.
      View in: PubMed   Mentions:
    6. Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. Nat Commun. 2023 04 11; 14(1):2045. Choi YJ, Yoo JS, Jung K, Rice L, Kim D, Zlojutro V, Frimel M, Madden E, Choi UY, Foo SS, Choi Y, Jiang Z, Johnson H, Kwak MJ, Kang S, Hong B, Seo GJ, Kim S, Lee SA, Amini-Bavil-Olyaee S, Maazi H, Akbari O, Asosingh K, Jung JU. PMID: 37041174; PMCID: PMC10090139.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability. Nat Commun. 2022 08 31; 13(1):5118. Hurrell BP, Helou DG, Howard E, Painter JD, Shafiei-Jahani P, Sharpe AH, Akbari O. PMID: 36045140; PMCID: PMC9433378.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells. J Allergy Clin Immunol. 2023 02; 151(2):526-538.e8. Helou DG, Quach C, Fung M, Painter JD, Hurrell BP, Eddie Loh YH, Howard E, Shafiei-Jahani P, Soroosh P, Sharpe AH, Akbari O. PMID: 35963455; PMCID: PMC9905221.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Analysis of the interplay between hepatitis B virus-positive hepatocytes and Kupffer cells ex vivo using mice as a model. STAR Protoc. 2022 06 17; 3(2):101364. Li Y, Lee J, Helou DG, Akbari O, Ou JJ. PMID: 35573478; PMCID: PMC9097500.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection. Front Immunol. 2022; 13:831103. Ung N, Goldbeck C, Man C, Hoeflich J, Sun R, Barbetta A, Matasci N, Katz J, Lee JSH, Chopra S, Asgharzadeh S, Warren M, Sher L, Kohli R, Akbari O, Genyk Y, Emamaullee J. PMID: 35432320; PMCID: PMC9009043.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Near-roadway air pollution, immune cells and adipokines among obese young adults. Environ Health. 2022 03 19; 21(1):36. Rahman MM, Liu FF, Eckel SP, Sankaranarayanan I, Shafiei-Jahani P, Howard E, Baronikian L, Sattler F, Lurmann FW, Allayee H, Akbari O, McConnell R. PMID: 35305663; PMCID: PMC8933931.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    12. Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nat Commun. 2022 03 17; 13(1):1440. Galle-Treger L, Helou DG, Quach C, Howard E, Hurrell BP, Muench GRA, Shafiei-Jahani P, Painter JD, Iorga A, Dara L, Emamaullee J, Golden-Mason L, Rosen HR, Soroosh P, Akbari O. PMID: 35301333; PMCID: PMC8931085.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    13. Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity. J Allergy Clin Immunol. 2022 05; 149(5):1628-1642.e10. Hurrell BP, Helou DG, Shafiei-Jahani P, Howard E, Painter JD, Quach C, Akbari O. PMID: 34673048; PMCID: PMC9013728.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma. Front Immunol. 2021; 12:733136. Howard E, Hurrell BP, Helou DG, Quach C, Painter JD, Shafiei-Jahani P, Fung M, Gill PS, Soroosh P, Sharpe AH, Akbari O. PMID: 34531874; PMCID: PMC8438316.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes. Front Immunol. 2021; 12:727008. Painter JD, Akbari O. PMID: 34489979; PMCID: PMC8416625.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation. mBio. 2021 08 31; 12(4):e0117621. Matundan HH, Jaggi U, Yu J, Akbari O, Ghiasi H. PMID: 34281386; PMCID: PMC8406230.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Creation of a Single Cell RNASeq Meta-Atlas to Define Human Liver Immune Homeostasis. Front Immunol. 2021; 12:679521. Rocque B, Barbetta A, Singh P, Goldbeck C, Helou DG, Loh YE, Ung N, Lee J, Akbari O, Emamaullee J. PMID: 34335581; PMCID: PMC8322955.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. J Allergy Clin Immunol. 2022 01; 149(1):223-236.e6. Helou DG, Shafiei-Jahani P, Hurrell BP, Painter JD, Quach C, Howard E, Akbari O. PMID: 34144112; PMCID: PMC8674385.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma. Nat Commun. 2021 05 05; 12(1):2526. Shafiei-Jahani P, Helou DG, Hurrell BP, Howard E, Quach C, Painter JD, Galle-Treger L, Li M, Loh YE, Akbari O. PMID: 33953190; PMCID: PMC8100131.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    20. Correction for Hirose et al., "Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells". J Virol. 2021 Apr 12; 95(9). Hirose S, Kato M, Tormanen K, Shafiei Jahani P, Akbari O, Ghiasi H. PMID: 33846270; PMCID: PMC8104103.
      View in: PubMed   Mentions:    Fields:    
    21. CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation. Mucosal Immunol. 2021 07; 14(4):899-911. Shafiei-Jahani P, Helou DG, Hurrell BP, Galle-Treger L, Howard E, Quach C, Painter JD, Fung M, Lo R, Allayee H, Akbari O. PMID: 33731828; PMCID: PMC8225558.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells. J Virol. 2021 01 28; 95(4). Hirose S, Kato M, Tormanen K, Shafiei Jahani P, Akbari O, Ghiasi H. PMID: 33208451; PMCID: PMC7851570.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. AMPK induces regulatory innate lymphoid cells after traumatic brain injury. JCI Insight. 2021 01 11; 6(1). Baban B, Braun M, Khodadadi H, Ward A, Alverson K, Malik A, Nguyen K, Nazarian S, Hess DC, Forseen S, Post AF, Vale FL, Vender JR, Hoda MN, Akbari O, Vaibhav K, Dhandapani KM. PMID: 33427206; PMCID: PMC7821592.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    24. Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity. Front Immunol. 2020; 11:542818. Hurrell BP, Howard E, Galle-Treger L, Helou DG, Shafiei-Jahani P, Painter JD, Akbari O. PMID: 33193309; PMCID: PMC7662114.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus. Nat Commun. 2020 09 18; 11(1):4718. Shafiei-Jahani P, Hurrell BP, Galle-Treger L, Helou DG, Howard E, Painter J, Lo R, Lewis G, Soroosh P, Akbari O. PMID: 32948777; PMCID: PMC7501856.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis. iScience. 2020 Oct 23; 23(10):101549. Hirose S, Jahani PS, Wang S, Jaggi U, Tormanen K, Yu J, Kato M, Akbari O, Ghiasi H. PMID: 33083718; PMCID: PMC7522755.
      View in: PubMed   Mentions: 10  
    27. IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity. J Allergy Clin Immunol. 2021 04; 147(4):1281-1295.e5. Howard E, Lewis G, Galle-Treger L, Hurrell BP, Helou DG, Shafiei-Jahani P, Painter JD, Muench GA, Soroosh P, Akbari O. PMID: 32905799.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    28. Feasibility of quantifying change in immune white cells in abdominal adipose tissue in response to an immune modulator in clinical obesity. PLoS One. 2020; 15(9):e0237496. Sattler FR, Mert M, Sankaranarayanan I, Mack WJ, Galle-Treger L, Gonzalez E, Baronikian L, Lee K, Jahani PS, Hodis HN, Dieli-Conwright C, Akbari O. PMID: 32881912; PMCID: PMC7470412.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    29. PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity. Nat Commun. 2020 08 10; 11(1):3998. Helou DG, Shafiei-Jahani P, Lo R, Howard E, Hurrell BP, Galle-Treger L, Painter JD, Lewis G, Soroosh P, Sharpe AH, Akbari O. PMID: 32778730; PMCID: PMC7417739.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    30. Perinatal nicotine exposure-induced transgenerational asthma: Effects of reexposure in F1 gestation. FASEB J. 2020 09; 34(9):11444-11459. Liu J, Yu C, Doherty TM, Akbari O, Allard P, Rehan VK. PMID: 32654256; PMCID: PMC7839813.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    31. Role of Autophagy in Lung Inflammation. Front Immunol. 2020; 11:1337. Painter JD, Galle-Treger L, Akbari O. PMID: 32733448; PMCID: PMC7358431.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    32. Repopulation of T, B, and NK cells following alemtuzumab treatment in relapsing-remitting multiple sclerosis. J Neuroinflammation. 2020 Jun 15; 17(1):189. Gilmore W, Lund BT, Li P, Levy AM, Kelland EE, Akbari O, Groshen S, Cen SY, Pelletier D, Weiner LP, Javed A, Dunn JE, Traboulsee AL. PMID: 32539719; PMCID: PMC7296935.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsCTClinical Trials
    33. Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma. Nat Commun. 2020 04 15; 11(1):1776. Han Y, Jia Q, Jahani PS, Hurrell BP, Pan C, Huang P, Gukasyan J, Woodward NC, Eskin E, Gilliland FD, Akbari O, Hartiala JA, Allayee H. PMID: 32296059; PMCID: PMC7160128.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    34. TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity. Cell Rep. 2019 12 24; 29(13):4509-4524.e5. Hurrell BP, Galle-Treger L, Jahani PS, Howard E, Helou DG, Banie H, Soroosh P, Akbari O. PMID: 31875557; PMCID: PMC6940205.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    35. A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity. PLoS Genet. 2019 12; 15(12):e1008528. Maazi H, Hartiala JA, Suzuki Y, Crow AL, Shafiei Jahani P, Lam J, Patel N, Rigas D, Han Y, Huang P, Eskin E, Lusis AJ, Gilliland FD, Akbari O, Allayee H. PMID: 31869344; PMCID: PMC6944376.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    36. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019 12 12; 10(1):5681. Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, Sands N, O'Connell D, Restrepo-Vassalli S, Chai B, Nemecio D, Punj V, Akbari O, Idos GE, Mumenthaler SM, Wu N, Martin SE, Hagiya A, Hicks J, Cui H, Liang C. PMID: 31831743; PMCID: PMC6908726.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    37. Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function. J Allergy Clin Immunol. 2020 02; 145(2):502-517.e5. Galle-Treger L, Hurrell BP, Lewis G, Howard E, Jahani PS, Banie H, Razani B, Soroosh P, Akbari O. PMID: 31738991; PMCID: PMC7010567.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    38. Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation. Front Immunol. 2019; 10:2051. Lewis G, Wang B, Shafiei Jahani P, Hurrell BP, Banie H, Aleman Muench GR, Maazi H, Helou DG, Howard E, Galle-Treger L, Lo R, Santosh S, Baltus A, Bongers G, San-Mateo L, Gilliland FD, Rehan VK, Soroosh P, Akbari O. PMID: 31620118; PMCID: PMC6760365.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    39. Immunologic benefit of maternal donors in pediatric living donor liver transplantation. Pediatr Transplant. 2019 11; 23(7):e13560. Kim MH, Akbari O, Genyk Y, Kohli R, Emamaullee J. PMID: 31402535.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. Roles of Type 1, 2, and 3 Innate Lymphoid Cells in Herpes Simplex Virus 1 Infection In Vitro and In Vivo. J Virol. 2019 07 01; 93(13). Hirose S, Wang S, Tormanen K, Wang Y, Tang J, Akbari O, Ghiasi H. PMID: 31019056; PMCID: PMC6580970.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    41. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance. Nat Commun. 2019 04 12; 10(1):1693. Li S, Song Y, Quach C, Guo H, Jang GB, Maazi H, Zhao S, Sands NA, Liu Q, In GK, Peng D, Yuan W, Machida K, Yu M, Akbari O, Hagiya A, Yang Y, Punj V, Tang L, Liang C. PMID: 30979895; PMCID: PMC6461621.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    42. Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice. Sci Rep. 2019 02 12; 9(1):1816. Woodward NC, Crow AL, Zhang Y, Epstein S, Hartiala J, Johnson R, Kocalis H, Saffari A, Sankaranarayanan I, Akbari O, Ramanathan G, Araujo JA, Finch CE, Bouret SG, Sioutas C, Morgan TE, Allayee H. PMID: 30755631; PMCID: PMC6372675.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    43. Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. Nat Commun. 2019 02 12; 10(1):713. Galle-Treger L, Sankaranarayanan I, Hurrell BP, Howard E, Lo R, Maazi H, Lewis G, Banie H, Epstein AL, Hu P, Rehan VK, Gilliland FD, Allayee H, Soroosh P, Sharpe AH, Akbari O. PMID: 30755607; PMCID: PMC6372786.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    44. Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma. Front Immunol. 2018; 9:2694. Hurrell BP, Shafiei Jahani P, Akbari O. PMID: 30524437; PMCID: PMC6256740.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    45. Herpes Simplex Virus 1 Specifically Targets Human CD1d Antigen Presentation To Enhance Its Pathogenicity. J Virol. 2018 11 15; 92(22). Rao P, Wen X, Lo JH, Kim S, Li X, Chen S, Feng X, Akbari O, Yuan W. PMID: 30185591; PMCID: PMC6206489.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    46. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. J Allergy Clin Immunol. 2018 12; 142(6):1894-1908.e7. Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Camacho V, Minami K, Nian Y, Koduru S, El Fatimy R, Ghiran I, Trachtenberg AJ, de la Fuente MA, Azuma H, Akbari O, Tullius SG, Vasudevan A, Elkhal A. PMID: 29470999; PMCID: PMC6454881.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. IL-10, TGF-β, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol. 2018 03; 141(3):1147-1151.e8. Ogasawara N, Poposki JA, Klingler AI, Tan BK, Weibman AR, Hulse KE, Stevens WW, Peters AT, Grammer LC, Schleimer RP, Welch KC, Smith SS, Conley DB, Raviv JR, Soroosh P, Akbari O, Himi T, Kern RC, Kato A. PMID: 29074458; PMCID: PMC5844803.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    48. Increased Innate Lymphoid Cells in Periodontal Tissue of the Murine Model of Periodontitis: The Role of AMP-Activated Protein Kinase and Relevance for the Human Condition. Front Immunol. 2017; 8:922. Qin X, Hoda MN, Susin C, Wheeler JN, Marshall B, Perry L, Saad N, Yin L, Elsayed R, Elsalanty M, Abdelsayed R, Yu JC, Dhandapani KM, Akbari O, Mozaffari MS, Baban B. PMID: 28861078; PMCID: PMC5559469.
      View in: PubMed   Mentions: 11     Fields:    
    49. Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation. Antimicrob Agents Chemother. 2017 08; 61(8). Bensman TJ, Jayne JG, Sun M, Kimura E, Meinert J, Wang JC, Schaal JB, Tran D, Rao AP, Akbari O, Selsted ME, Beringer PM. PMID: 28559270; PMCID: PMC5527632.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    50. Type two innate lymphoid cells: the Janus cells in health and disease. Immunol Rev. 2017 07; 278(1):192-206. Maazi H, Akbari O. PMID: 28658553; PMCID: PMC5492968.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    51. Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell-mediated airway hyperreactivity. J Allergy Clin Immunol. 2018 03; 141(3):893-905.e6. Maazi H, Banie H, Aleman Muench GR, Patel N, Wang B, Sankaranarayanan I, Bhargava V, Sato T, Lewis G, Cesaroni M, Karras J, Das A, Soroosh P, Akbari O. PMID: 28579374.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    52. Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps. Immun Inflamm Dis. 2017 09; 5(3):233-243. Poposki JA, Klingler AI, Tan BK, Soroosh P, Banie H, Lewis G, Hulse KE, Stevens WW, Peters AT, Grammer LC, Schleimer RP, Welch KC, Smith SS, Conley DB, Raviv JR, Karras JG, Akbari O, Kern RC, Kato A. PMID: 28474861; PMCID: PMC5569375.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    53. Reply. J Allergy Clin Immunol. 2017 02; 139(2):712-713. Maazi H, Suzuki Y, Jung J, Akbari O. PMID: 27847142.
      View in: PubMed   Mentions:    Fields:    
    54. Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity. Nat Commun. 2016 10 18; 7:13202. Galle-Treger L, Suzuki Y, Patel N, Sankaranarayanan I, Aron JL, Maazi H, Chen L, Akbari O. PMID: 27752043; PMCID: PMC5071851.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    55. Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction. J Allergy Clin Immunol. 2017 May; 139(5):1468-1477.e2. Rigas D, Lewis G, Aron JL, Wang B, Banie H, Sankaranarayanan I, Galle-Treger L, Maazi H, Lo R, Freeman GJ, Sharpe AH, Soroosh P, Akbari O. PMID: 27717665; PMCID: PMC5378695.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    56. Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. J Neuroimmunol. 2016 10 15; 299:70-78. Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJGM, Aswad DW, Laird-Offringa IA. PMID: 27725125; PMCID: PMC5152694.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    57. Innate lymphoid cells: a paradigm for low SSI in cleft lip repair. J Surg Res. 2016 10; 205(2):312-317. Simmerman E, Qin X, Marshall B, Perry L, Cai L, Wang T, Yu J, Akbari O, Baban B. PMID: 27664878.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    58. IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Rep. 2016 07 12; 16(2):405-418. Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P. PMID: 27346349; PMCID: PMC5293007.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    59. Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016 05 17; 44(5):1204-14. Tian Y, Kuo CF, Akbari O, Ou JH. PMID: 27156385; PMCID: PMC4871724.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    60. Lower omental t-regulatory cell count is associated with higher fasting glucose and lower β-cell function in adults with obesity. Obesity (Silver Spring). 2016 06; 24(6):1274-82. Gyllenhammer LE, Lam J, Alderete TL, Allayee H, Akbari O, Katkhouda N, Goran MI. PMID: 27133873; PMCID: PMC4882248.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    61. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):172-80. Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, Golub ET, Sharp GB, Kovacs A. PMID: 26761519; PMCID: PMC4712709.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    62. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol. 2016 05; 137(5):1382-1389.e9. Suzuki Y, Maazi H, Sankaranarayanan I, Lam J, Khoo B, Soroosh P, Barbers RG, James Ou JH, Jung JU, Akbari O. PMID: 26589586; PMCID: PMC4860134.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    63. ICOS regulates ILC2s in asthma. Oncotarget. 2015 Sep 22; 6(28):24584-5. Maazi H, Akbari O. PMID: 26309088; PMCID: PMC4694773.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    64. A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model. J Immunol. 2015 Aug 15; 195(4):1459-69. Wen X, Kim S, Xiong R, Li M, Lawrenczyk A, Huang X, Chen SY, Rao P, Besra GS, Dellabona P, Casorati G, Porcelli SA, Akbari O, Exley MA, Yuan W. PMID: 26157173; PMCID: PMC4530047.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    65. ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity. 2015 Mar 17; 42(3):538-51. Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O. PMID: 25769613; PMCID: PMC4366271.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCells
    66. Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells. Immunobiology. 2015 Apr; 220(4):518-24. Mott KR, Maazi H, Allen SJ, Zandian M, Matundan H, Ghiasi YN, Sharifi BG, Underhill D, Akbari O, Ghiasi H. PMID: 25468565; PMCID: PMC4355210.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    67. Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. PLoS One. 2014; 9(1):e87617. Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H. PMID: 24475315; PMCID: PMC3903765.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    68. Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. PLoS One. 2013; 8(3):e59599. Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O. PMID: 23555047; PMCID: PMC3598698.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    69. Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity. J Allergy Clin Immunol. 2013 Apr; 131(4):1048-57, 1057.e1-2. Kerzerho J, Maazi H, Speak AO, Szely N, Lombardi V, Khoo B, Geryak S, Lam J, Soroosh P, Van Snick J, Akbari O. PMID: 23174661; PMCID: PMC3651917.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    70. Perinatal nicotine exposure induces asthma in second generation offspring. BMC Med. 2012 Oct 30; 10:129. Rehan VK, Liu J, Naeem E, Tian J, Sakurai R, Kwong K, Akbari O, Torday JS. PMID: 23106849; PMCID: PMC3568737.
      View in: PubMed   Mentions: 85     Fields:    Translation:Animals
    71. Sex-specific perinatal nicotine-induced asthma in rat offspring. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):53-62. Liu J, Naeem E, Tian J, Lombardi V, Kwong K, Akbari O, Torday JS, Rehan VK. PMID: 23002101; PMCID: PMC3547089.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    72. Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. J Immunol. 2012 Mar 01; 188(5):2254-65. Kerzerho J, Yu ED, Barra CM, Alari-Pahissa E, Alari-Pahisa E, Girardi E, Harrak Y, Lauzurica P, Llebaria A, Zajonc DM, Akbari O, Castaño AR. PMID: 22301545; PMCID: PMC3288653.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    73. Effects of systemic versus local administration of corticosteroids on mucosal tolerance. J Immunol. 2012 Jan 01; 188(1):470-6. Kerzerho J, Wunsch D, Szely N, Meyer HA, Lurz L, Röse L, Wahn U, Akbari O, Stock P. PMID: 22105997; PMCID: PMC3253659.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    74. Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan; 121(1):277-87. Li M, Krishnaveni MS, Li C, Zhou B, Xing Y, Banfalvi A, Li A, Lombardi V, Akbari O, Borok Z, Minoo P. PMID: 21135509; PMCID: PMC3007138.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    75. TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. J Immunol. 2010 Dec 01; 185(11):6839-49. Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH. PMID: 21037090; PMCID: PMC3153437.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    76. A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. J Immunol. 2010 Feb 15; 184(4):2107-15. Lombardi V, Stock P, Singh AK, Kerzerho J, Yang W, Sullivan BA, Li X, Shiratsuchi T, Hnatiuk NE, Howell AR, Yu KO, Porcelli SA, Tsuji M, Kronenberg M, Wilson SB, Akbari O. PMID: 20083656; PMCID: PMC2845715.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    77. Dendritic cell modulation as a new interventional approach for the treatment of asthma. Drug News Perspect. 2009 Oct; 22(8):445-51. Lombardi V, Akbari O. PMID: 20016853; PMCID: PMC2845716.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    78. The role of costimulatory molecules in allergic disease and asthma. Int Arch Allergy Immunol. 2010; 151(3):179-89. Lombardi V, Singh AK, Akbari O. PMID: 19786798; PMCID: PMC2837887.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    79. PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. Mucosal Immunol. 2010 Jan; 3(1):81-91. Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, Sharpe AH, Umetsu DT, Dekruyff RH. PMID: 19741598; PMCID: PMC2845714.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    80. Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 2009 Apr 15; 182(8):5116-22. Stock P, Lombardi V, Kohlrautz V, Akbari O. PMID: 19342692; PMCID: PMC2837931.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    81. Natural killer T cells in the lungs of patients with asthma. J Allergy Clin Immunol. 2009 May; 123(5):1181-5. Matangkasombut P, Marigowda G, Ervine A, Idris L, Pichavant M, Kim HY, Yasumi T, Wilson SB, DeKruyff RH, Faul JL, Israel E, Akbari O, Umetsu DT. PMID: 19356791; PMCID: PMC2734957.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    82. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice. J Immunol. 2008 Oct 01; 181(7):4560-4569. Koh YI, Kim HY, Meyer EH, Pichavant M, Akbari O, Yasumi T, Savage PB, DeKruyff RH, Umetsu DT. PMID: 18802058; PMCID: PMC4884641.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    83. Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop. Eur J Immunol. 2008 Jun; 38(6):1756-66. Exley MA, Hou R, Shaulov A, Tonti E, Dellabona P, Casorati G, Akbari O, Akman HO, Greenfield EA, Gumperz JE, Boyson JE, Balk SP, Wilson SB. PMID: 18493987; PMCID: PMC2864538.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    84. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol. 2008 Apr 15; 180(8):5448-56. Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. PMID: 18390727; PMCID: PMC2835525.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    85. Recent advances in the role of NKT cells in allergic diseases and asthma. Curr Allergy Asthma Rep. 2008 Apr; 8(2):165-70. Stock P, Akbari O. PMID: 18417059.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    86. Invariant natural killer T cells in obstructive pulmonary diseases. N Engl J Med. 2007 Jul 12; 357(2):193-4; author reply 194-5. Akbari O, Faul JL, Umetsu DT. PMID: 17625134.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    87. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med. 2006 Mar 16; 354(11):1117-29. Akbari O, Faul JL, Hoyte EG, Berry GJ, Wahlström J, Kronenberg M, DeKruyff RH, Umetsu DT. PMID: 16540612.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    88. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2782-7. Meyer EH, Goya S, Akbari O, Berry GJ, Savage PB, Kronenberg M, Nakayama T, DeKruyff RH, Umetsu DT. PMID: 16478801; PMCID: PMC1413796.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    89. Respiratory tolerance is inhibited by the administration of corticosteroids. J Immunol. 2005 Dec 01; 175(11):7380-7. Stock P, Akbari O, DeKruyff RH, Umetsu DT. PMID: 16301645.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    90. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol. 2005 May; 6(5):447-54. Umetsu SE, Lee WL, McIntire JJ, Downey L, Sanjanwala B, Akbari O, Berry GJ, Nagumo H, Freeman GJ, Umetsu DT, DeKruyff RH. PMID: 15793575.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    91. Role of regulatory dendritic cells in allergy and asthma. Curr Allergy Asthma Rep. 2005 Jan; 5(1):56-61. Akbari O, Umetsu DT. PMID: 15659264.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    92. Role of regulatory dendritic cells in allergy and asthma. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):533-8. Akbari O, Umetsu DT. PMID: 15640695.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    93. Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat Immunol. 2004 Nov; 5(11):1149-56. Stock P, Akbari O, Berry G, Freeman GJ, Dekruyff RH, Umetsu DT. PMID: 15448689.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    94. CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation. Eur J Immunol. 2004 Jul; 34(7):1817-27. Stock P, Kallinich T, Akbari O, Quarcoo D, Gerhold K, Wahn U, Umetsu DT, Hamelmann E. PMID: 15214030.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    95. Role of regulatory T cells in allergy and asthma. Curr Opin Immunol. 2003 Dec; 15(6):627-33. Akbari O, Stock P, DeKruyff RH, Umetsu DT. PMID: 14630195.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    96. Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol. 2003 Sep; 112(3):480-7; quiz 488. Umetsu DT, Akbari O, Dekruyff RH. PMID: 13679803.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    97. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med. 2003 May; 9(5):582-8. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT. PMID: 12669034.
      View in: PubMed   Mentions: 274     Fields:    Translation:AnimalsCells
    98. Mucosal tolerance and immunity: regulating the development of allergic disease and asthma. Int Arch Allergy Immunol. 2003 Feb; 130(2):108-18. Akbari O, Stock P, DeKruyff RH, Umetsu DT. PMID: 12673064.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    99. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol. 2002 Sep; 110(3):460-8. Oh JW, Seroogy CM, Meyer EH, Akbari O, Berry G, Fathman CG, Dekruyff RH, Umetsu DT. PMID: 12209095.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    100. Asthma: an epidemic of dysregulated immunity. Nat Immunol. 2002 Aug; 3(8):715-20. Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH. PMID: 12145657.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansCellsPHPublic Health
    101. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32. Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. PMID: 12145647.
      View in: PubMed   Mentions: 235     Fields:    Translation:AnimalsCells
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