Omid Akbari, PhD

Photo of Omid Akbari, PhD
Title(s)Professor of Immunology and Immune Therapeutics and Medicine
SchoolKeck School of Medicine of Usc
AddressNRT 5505 1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 7930
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    Collapse Overview 
    Collapse overview
    We are cellular and molecular immunologists dedicated to advancing the understanding of the immune system. Our laboratory focuses on characterizing both innate and acquired immune responses, uncovering the mechanisms that regulate them, and investigating how they contribute to inflammatory diseases. We manipulate cell signaling pathways, costimulatory molecules, and cellular energy sources to modulate immune function and improve human health. Ultimately, our goal is to identify precise strategies to harness and control these responses for therapeutic benefit.

    Collapse Biography 
    Collapse awards and honors
    USC2025  - 2030Omid Akbari
    Stanford University2001  - 2003American Lung Association award
    Stanford University and Harvard Medical School2003  - 2005American Lung Association Grant Award
    Stanford University2003Pharmacia Research Foundation Award for the best research in the field of Immunology, Stockholm
    Stanford University2004Pharmacia Research Foundation Award for the best research in the field of Immunology, Amsterdam
    Harvard Medical School2005Pharmacia Research Foundation Award for the best research in the field of Immunology, Munich
    Harvard Medical School2005Henning Lowenstein Award for the best research in the field of Allergy and Immunology, Munich
    Harvard Medical School2007  - 2008Eleanor & Miles Shore Career Development Award
    Harvard Medical School2007  - 2008Children’s Hospital of Boston Career Development Award
    University of Southern California 2012  - 2013Ideas Empowered Award
    University of Southern California2017  - 2018National Academy of Inventors Award
    University of Southern California2023Keck School of Medicine Dean’s award for scholarship

    Collapse Research 
    Collapse research activities and funding
    Mechanisms of Perinatal Nicotine Vaping-Induced Pulmonary ILC2 Dysregulation and Allergic Asthma Development
    NIH R01HL183124Sep 1, 2026 - May 31, 2030
    Role: Co-Principal Investigator
    Study the role of ICOS on murine and human ILC2s
    NIH R01AI181866Jun 11, 2025 - May 31, 2030
    Role: Principal Investigator
    Transcriptional and metabolomic regulation of IL-10 in pulmonary ILC2s
    NIH R01AI169687Sep 20, 2022 - Jul 31, 2027
    Role: Principal Investigator
    Role of TNF receptor 2 on Pulmonary Group 2 Innate Lymphoid Cells
    NIH R01HL159804Dec 15, 2021 - Nov 30, 2025
    Role: Principal Investigator
    Study the link of autophagy dysfunction to allergic and neutrophilic asthma onset
    NIH R01HL151493Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Induction of cells and pathways that promote respiratory tolerance in allergic asthma
    NIH R01HL144790Sep 1, 2019 - Aug 31, 2023
    Role: Principal Investigator
    Maternal effect on offspring immunity against hepatitis B virus
    NIH R01AI145813Jul 3, 2019 - Jun 30, 2025
    Role: Co-Principal Investigator
    Role of Microbiome Sodium Butyrate in regulation of ILC2 dependent airway hyperreactivity
    NIH R21AI132084May 18, 2017 - Apr 30, 2020
    Role: Principal Investigator
    The function of CRAC channels in airway inflammation
    NIH R21AI109059Jan 1, 2016 - Dec 31, 2017
    Role: Co-Principal Investigator
    Genetic and Environmental Determinants of Asthma Endophenotypes
    NIH R01ES025786Aug 1, 2015 - Apr 30, 2021
    Role: Co-Principal Investigator
    Air pollution, immune modulation of adipose tissue and type-2 diabetes risk factors
    NIH R21ES024707Jul 10, 2014 - Jun 30, 2018
    Role: Co-Principal Investigator
    INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMA
    NIH R01ES021801Aug 1, 2012 - Oct 31, 2019
    Role: Co-Principal Investigator
    Role of NKT cells in airway hyperreactivity &tolerance
    NIH R01AI066020Sep 20, 2007 - Aug 31, 2014
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Faculty Mentoring
    Completed SC CTSI Mentor Training: Yes

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Unraveling the autoimmune architecture of pemphigus: from B-cell depletion to network-based immune engineering. Front Immunol. 2026; 17:1844632. Shafiei-Jahani P, Li X, Akbari A, Vera A, Haniff E, Carlisle R, Akbari O, Holland V. PMID: 42483189; PMCID: PMC13384940.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Autophagy as a Redox Rheostat Linking Cigarette Smoke, Electronic Cigarettes, and Nicotine Exposure to Lung Development, Disease, and Interorgan Communication. Compr Physiol. 2026 Jun; 16(3):e70167. Lotfi N, Rezaei N, Chandan G, Akbari O, Rehan VK. PMID: 42104610.
      View in: PubMed   Mentions:    Fields:    
    3. Melatonin suppresses ILC2-driven airway hyperreactivity via glutathione-dependent metabolic reprogramming. Front Immunol. 2026; 17:1845654. Cain J, Hurrell BP, Shen S, Speliakos P, Akbari O. PMID: 42199420; PMCID: PMC13199098.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Beyond ATP: Lipid-Driven Plasticity and the Immunometabolism of ILC2s. Cells. 2026 May 03; 15(9). Pesold VV, Cain J, Bensinger SJ, Akbari O. PMID: 42121939; PMCID: PMC13162699.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Tim-3 agonist restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway. Nat Commun. 2026 Apr 01; 17(1). Sakano Y, Sakano K, Kokubo K, Hurrell BP, Shen S, Li X, Swamy GYS, Cain J, Kuchroo VK, Akbari O. PMID: 41922900; PMCID: PMC13212748.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance. Front Med (Lausanne). 2026; 13:1805170. Shafiei-Jahani P, Li X, Akbari A, Haniff E, Ziprick M, Carlisle R, Goh C, Holland V, Akbari O. PMID: 41987782; PMCID: PMC13076271.
      View in: PubMed   Mentions:
    7. Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity. Cell Rep. 2026 Mar 17; 45(4):117123. Dong P, Liu L, Yu J, Li N, Davidorf B, Shen S, Bouch R, Zhang J, Ho D, Xiao G, Akbari O, Zhang B, He Z. PMID: 41849346.
      View in: PubMed   Mentions:    Fields:    
    8. Targeting CD48 Ameliorates ILC2-mediated Airway Hyperreactivity by Disrupting the PKCβ Pathway. Am J Respir Cell Mol Biol. 2026 01 01; 74(1):65-79. Sakano K, Sakano Y, Hurrell BP, Kazemi MH, Li X, Shen S, Akbari O. PMID: 40720762.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. The Expanding Role of ILC2s in Allergic Airways Disease. Allergy. 2026 01; 81(1):11-23. Cain J, Hurrell B, Akbari O. PMID: 40891582; PMCID: PMC13282975.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. HPV16 E6 and E7 expressing cancer cells suppress the antitumor immune response by upregulating KLF2-mediated IL-23 expression in macrophages. J Immunother Cancer. 2025 Aug 19; 13(8). Prins R, Fernandez DJ, Akbari O, Da Silva DM, Kast WM. PMID: 40829900; PMCID: PMC12366621.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis. J Clin Invest. 2025 09 16; 135(18). Sakano Y, Sakano K, Hurrell BP, Kazemi MH, Li X, Shen S, Akbari O. PMID: 40627441; PMCID: PMC12435846.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Multiple chemical sensitivity (MCS) validity, prevalence, tools and interventions: systematic review protocol. BMJ Open. 2025 May 08; 15(5):e088136. Hempel S, Zhang D, Robinson KA, Yagyu S, Miles J, Motala A, Tolentino D, Akbari O, Danz M, Johnston J. PMID: 40345685; PMCID: PMC12067775.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. BTLA agonist attenuates Th17-driven inflammation in a mouse model of steroid-resistant asthma. Front Immunol. 2025; 16:1552394. Quach C, Li X, Shafiei-Jahani P, Li M, Shen S, Helou DG, Hurrell BP, Soroosh P, Akbari O. PMID: 40226621; PMCID: PMC11986467.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Integrated workflow for analysis of immune enriched spatial proteomic data with IMmuneCite. Sci Rep. 2025 Mar 19; 15(1):9394. Barbetta A, Bangerth S, Lee JTC, Rocque B, Roussos Torres ET, Kohli R, Akbari O, Emamaullee J. PMID: 40102469; PMCID: PMC11920390.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    15. FOXO1 pathway activation by VISTA immune checkpoint restrains pulmonary ILC2 functions. J Clin Invest. 2025 Jan 02; 135(4). Kazemi MH, Momeni-Varposhti Z, Li X, Hurrell BP, Sakano Y, Shen S, Shafiei-Jahani P, Sakano K, Akbari O. PMID: 39745792; PMCID: PMC11827891.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Sensory neurons regulate stimulus-dependent humoral immunity in mouse models of bacterial infection and asthma. Nat Commun. 2024 10 16; 15(1):8914. Aguilar D, Zhu F, Millet A, Millet N, Germano P, Pisegna J, Akbari O, Doherty TA, Swidergall M, Jendzjowsky N. PMID: 39414787; PMCID: PMC11484968.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism. Cell Mol Immunol. 2024 10; 21(10):1158-1174. Sakano Y, Sakano K, Hurrell BP, Shafiei-Jahani P, Kazemi MH, Li X, Shen S, Barbers R, Akbari O. PMID: 39160226; PMCID: PMC11442993.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Sensory neurons regulate stimulus-dependent humoral immunity. bioRxiv. 2024 Aug 13. Aguilar D, Zhu F, Millet A, Millet N, Germano P, Pisegna J, Akbari O, Doherty TA, Swidergall M, Jendzjowsky N. PMID: 38260709; PMCID: PMC10802321.
      View in: PubMed   Mentions:
    19. IMmuneCite: an integrated workflow for analysis of immune enriched spatial proteomic data. Res Sq. 2024 Jul 09. Barbetta A, Bangerth S, Lee JTC, Rocque B, Roussos Torres ET, Kohli R, Akbari O, Emamaullee J. PMID: 39041033; PMCID: PMC11261960.
      View in: PubMed   Mentions:
    20. CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus. Cell Rep. 2024 07 23; 43(7):114434. Shafiei-Jahani P, Yan S, Kazemi MH, Li X, Akbari A, Sakano K, Sakano Y, Hurrell BP, Akbari O. PMID: 38963763; PMCID: PMC11317174.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function. Sci Transl Med. 2024 05 08; 16(746):eadk4728. Hurrell BP, Sakano Y, Shen S, Helou DG, Li M, Shafiei-Jahani P, Kazemi MH, Sakano K, Li X, Quach C, Barbers R, Akbari O. PMID: 38718131.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    22. Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection. Sci Adv. 2024 04 12; 10(15):eadm8841. Barbetta A, Rocque B, Bangerth S, Street K, Weaver C, Chopra S, Kim J, Sher L, Gaudilliere B, Akbari O, Kohli R, Emamaullee J. PMID: 38608023; PMCID: PMC11014454.
      View in: PubMed   Mentions: 5     Fields:    
    23. Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity. J Exp Med. 2024 May 06; 221(5). Hurrell BP, Shen S, Li X, Sakano Y, Kazemi MH, Quach C, Shafiei-Jahani P, Sakano K, Ghiasi H, Akbari O. PMID: 38530239; PMCID: PMC10965393.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    24. Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages. PLoS Pathog. 2024 03; 20(3):e1012079. Li Y, Wu C, Lee J, Ning Q, Lim J, Eoh H, Wang S, Hurrell BP, Akbari O, Ou JJ. PMID: 38466743; PMCID: PMC10957081.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    25. Technical optimization of spatially resolved single-cell transcriptomic datasets to study clinical liver disease. Sci Rep. 2024 02 13; 14(1):3612. Rocque B, Guion K, Singh P, Bangerth S, Pickard L, Bhattacharjee J, Eguizabal S, Weaver C, Chopra S, Zhou S, Kohli R, Sher L, Akbari O, Ekser B, Emamaullee JA. PMID: 38351241; PMCID: PMC10864257.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity. J Allergy Clin Immunol. 2024 May; 153(5):1406-1422.e6. Sakano Y, Sakano K, Hurrell BP, Helou DG, Shafiei-Jahani P, Kazemi MH, Li X, Shen S, Hilser JR, Hartiala JA, Allayee H, Barbers R, Akbari O. PMID: 38244725.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    27. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models. Nat Commun. 2023 09 26; 14(1):5989. Howard E, Hurrell BP, Helou DG, Shafiei-Jahani P, Hasiakos S, Painter J, Srikanth S, Gwack Y, Akbari O. PMID: 37752127; PMCID: PMC10522697.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    28. Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct. BMJ Open. 2023 09 22; 13(9):e072098. Hempel S, Danz M, Robinson KA, Bolshakova M, Rodriguez J, Mears A, Pham C, Yagyu S, Motala A, Tolentino D, Akbari O, Johnston J. PMID: 37739463; PMCID: PMC10533706.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    29. LAIR-1 limits macrophage activation in acute inflammatory lung injury. Mucosal Immunol. 2023 12; 16(6):788-800. Helou DG, Quach C, Hurrell BP, Li X, Li M, Akbari A, Shen S, Shafiei-Jahani P, Akbari O. PMID: 37634572; PMCID: PMC10842758.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    30. Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome. Cell Rep. 2023 08 29; 42(8):112990. Quach C, Helou DG, Li M, Hurrell BP, Howard E, Shafiei-Jahani P, Soroosh P, Ou JJ, Razani B, Rehan V, Akbari O. PMID: 37590140; PMCID: PMC10510741.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    31. Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection. Res Sq. 2023 Jul 03. Barbetta A, Rocque B, Bangerth S, Street K, Weaver C, Chopra S, Kim J, Sher L, Gaudilliere B, Akbari O, Kohli R, Emamaullee J. PMID: 37461437; PMCID: PMC10350170.
      View in: PubMed   Mentions:
    32. Altered Tumor Necrosis Factor Response in Neurologic Postacute SARS-CoV-2 Syndrome. J Interferon Cytokine Res. 2023 07; 43(7):307-313. Allan-Blitz LT, Goodrich J, Hu H, Akbari O, Klausner JD. PMID: 37384921; PMCID: PMC10354723.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. Unique immune and inflammatory cytokine profiles may define long COVID syndrome. Clin Exp Med. 2023 Oct; 23(6):2925-2930. Allan-Blitz LT, Akbari O, Kojima N, Saavedra E, Chellamuthu P, Denny N, MacMullan MA, Hess V, Shacreaw M, Brobeck M, Turner F, Slepnev VI, Ibrayeva A, Klausner JD. PMID: 37061998; PMCID: PMC10105906.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. Nat Commun. 2023 04 11; 14(1):2045. Choi YJ, Yoo JS, Jung K, Rice L, Kim D, Zlojutro V, Frimel M, Madden E, Choi UY, Foo SS, Choi Y, Jiang Z, Johnson H, Kwak MJ, Kang S, Hong B, Seo GJ, Kim S, Lee SA, Amini-Bavil-Olyaee S, Maazi H, Akbari O, Asosingh K, Jung JU. PMID: 37041174; PMCID: PMC10090139.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    35. PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability. Nat Commun. 2022 08 31; 13(1):5118. Hurrell BP, Helou DG, Howard E, Painter JD, Shafiei-Jahani P, Sharpe AH, Akbari O. PMID: 36045140; PMCID: PMC9433378.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    36. Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells. J Allergy Clin Immunol. 2023 02; 151(2):526-538.e8. Helou DG, Quach C, Fung M, Painter JD, Hurrell BP, Eddie Loh YH, Howard E, Shafiei-Jahani P, Soroosh P, Sharpe AH, Akbari O. PMID: 35963455; PMCID: PMC9905221.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    37. Analysis of the interplay between hepatitis B virus-positive hepatocytes and Kupffer cells ex vivo using mice as a model. STAR Protoc. 2022 06 17; 3(2):101364. Li Y, Lee J, Helou DG, Akbari O, Ou JJ. PMID: 35573478; PMCID: PMC9097500.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    38. Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection. Front Immunol. 2022; 13:831103. Ung N, Goldbeck C, Man C, Hoeflich J, Sun R, Barbetta A, Matasci N, Katz J, Lee JSH, Chopra S, Asgharzadeh S, Warren M, Sher L, Kohli R, Akbari O, Genyk Y, Emamaullee J. PMID: 35432320; PMCID: PMC9009043.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    39. Near-roadway air pollution, immune cells and adipokines among obese young adults. Environ Health. 2022 03 19; 21(1):36. Rahman MM, Liu FF, Eckel SP, Sankaranarayanan I, Shafiei-Jahani P, Howard E, Baronikian L, Sattler F, Lurmann FW, Allayee H, Akbari O, McConnell R. PMID: 35305663; PMCID: PMC8933931.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    40. Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nat Commun. 2022 03 17; 13(1):1440. Galle-Treger L, Helou DG, Quach C, Howard E, Hurrell BP, Muench GRA, Shafiei-Jahani P, Painter JD, Iorga A, Dara L, Emamaullee J, Golden-Mason L, Rosen HR, Soroosh P, Akbari O. PMID: 35301333; PMCID: PMC8931085.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    41. Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity. J Allergy Clin Immunol. 2022 05; 149(5):1628-1642.e10. Hurrell BP, Helou DG, Shafiei-Jahani P, Howard E, Painter JD, Quach C, Akbari O. PMID: 34673048; PMCID: PMC9013728.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma. Front Immunol. 2021; 12:733136. Howard E, Hurrell BP, Helou DG, Quach C, Painter JD, Shafiei-Jahani P, Fung M, Gill PS, Soroosh P, Sharpe AH, Akbari O. PMID: 34531874; PMCID: PMC8438316.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    43. Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes. Front Immunol. 2021; 12:727008. Painter JD, Akbari O. PMID: 34489979; PMCID: PMC8416625.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    44. Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation. mBio. 2021 08 31; 12(4):e0117621. Matundan HH, Jaggi U, Yu J, Akbari O, Ghiasi H. PMID: 34281386; PMCID: PMC8406230.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. Creation of a Single Cell RNASeq Meta-Atlas to Define Human Liver Immune Homeostasis. Front Immunol. 2021; 12:679521. Rocque B, Barbetta A, Singh P, Goldbeck C, Helou DG, Loh YE, Ung N, Lee J, Akbari O, Emamaullee J. PMID: 34335581; PMCID: PMC8322955.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    46. LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. J Allergy Clin Immunol. 2022 01; 149(1):223-236.e6. Helou DG, Shafiei-Jahani P, Hurrell BP, Painter JD, Quach C, Howard E, Akbari O. PMID: 34144112; PMCID: PMC8674385.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    47. CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma. Nat Commun. 2021 05 05; 12(1):2526. Shafiei-Jahani P, Helou DG, Hurrell BP, Howard E, Quach C, Painter JD, Galle-Treger L, Li M, Loh YE, Akbari O. PMID: 33953190; PMCID: PMC8100131.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    48. CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation. Mucosal Immunol. 2021 07; 14(4):899-911. Shafiei-Jahani P, Helou DG, Hurrell BP, Galle-Treger L, Howard E, Quach C, Painter JD, Fung M, Lo R, Allayee H, Akbari O. PMID: 33731828; PMCID: PMC8225558.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    49. Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells. J Virol. 2021 01 28; 95(4). Hirose S, Kato M, Tormanen K, Shafiei Jahani P, Akbari O, Ghiasi H. PMID: 33208451; PMCID: PMC7851570.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    50. AMPK induces regulatory innate lymphoid cells after traumatic brain injury. JCI Insight. 2021 01 11; 6(1). Baban B, Braun M, Khodadadi H, Ward A, Alverson K, Malik A, Nguyen K, Nazarian S, Hess DC, Forseen S, Post AF, Vale FL, Vender JR, Hoda MN, Akbari O, Vaibhav K, Dhandapani KM. PMID: 33427206; PMCID: PMC7821592.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    51. Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity. Front Immunol. 2020; 11:542818. Hurrell BP, Howard E, Galle-Treger L, Helou DG, Shafiei-Jahani P, Painter JD, Akbari O. PMID: 33193309; PMCID: PMC7662114.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    52. DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus. Nat Commun. 2020 09 18; 11(1):4718. Shafiei-Jahani P, Hurrell BP, Galle-Treger L, Helou DG, Howard E, Painter J, Lo R, Lewis G, Soroosh P, Akbari O. PMID: 32948777; PMCID: PMC7501856.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    53. Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis. iScience. 2020 Oct 23; 23(10):101549. Hirose S, Jahani PS, Wang S, Jaggi U, Tormanen K, Yu J, Kato M, Akbari O, Ghiasi H. PMID: 33083718; PMCID: PMC7522755.
      View in: PubMed   Mentions: 19  
    54. IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity. J Allergy Clin Immunol. 2021 04; 147(4):1281-1295.e5. Howard E, Lewis G, Galle-Treger L, Hurrell BP, Helou DG, Shafiei-Jahani P, Painter JD, Muench GA, Soroosh P, Akbari O. PMID: 32905799.
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    115. Respiratory tolerance is inhibited by the administration of corticosteroids. J Immunol. 2005 Dec 01; 175(11):7380-7. Stock P, Akbari O, DeKruyff RH, Umetsu DT. PMID: 16301645.
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    116. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol. 2005 May; 6(5):447-54. Umetsu SE, Lee WL, McIntire JJ, Downey L, Sanjanwala B, Akbari O, Berry GJ, Nagumo H, Freeman GJ, Umetsu DT, DeKruyff RH. PMID: 15793575.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    117. Role of regulatory dendritic cells in allergy and asthma. Curr Allergy Asthma Rep. 2005 Jan; 5(1):56-61. Akbari O, Umetsu DT. PMID: 15659264.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    118. Role of regulatory dendritic cells in allergy and asthma. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):533-8. Akbari O, Umetsu DT. PMID: 15640695.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    119. Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat Immunol. 2004 Nov; 5(11):1149-56. Stock P, Akbari O, Berry G, Freeman GJ, Dekruyff RH, Umetsu DT. PMID: 15448689.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    120. CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation. Eur J Immunol. 2004 Jul; 34(7):1817-27. Stock P, Kallinich T, Akbari O, Quarcoo D, Gerhold K, Wahn U, Umetsu DT, Hamelmann E. PMID: 15214030.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    121. Role of regulatory T cells in allergy and asthma. Curr Opin Immunol. 2003 Dec; 15(6):627-33. Akbari O, Stock P, DeKruyff RH, Umetsu DT. PMID: 14630195.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    122. Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol. 2003 Sep; 112(3):480-7; quiz 488. Umetsu DT, Akbari O, Dekruyff RH. PMID: 13679803.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    123. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med. 2003 May; 9(5):582-8. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT. PMID: 12669034.
      View in: PubMed   Mentions: 288     Fields:    Translation:AnimalsCells
    124. Mucosal tolerance and immunity: regulating the development of allergic disease and asthma. Int Arch Allergy Immunol. 2003 Feb; 130(2):108-18. Akbari O, Stock P, DeKruyff RH, Umetsu DT. PMID: 12673064.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    125. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol. 2002 Sep; 110(3):460-8. Oh JW, Seroogy CM, Meyer EH, Akbari O, Berry G, Fathman CG, Dekruyff RH, Umetsu DT. PMID: 12209095.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    126. Asthma: an epidemic of dysregulated immunity. Nat Immunol. 2002 Aug; 3(8):715-20. Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH. PMID: 12145657.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansCellsPHPublic Health
    127. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32. Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. PMID: 12145647.
      View in: PubMed   Mentions: 245     Fields:    Translation:AnimalsCells
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