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Omid Akbari, PhD

TitleProfessor of Molecular Microbiology & Immunology
InstitutionUniversity of Southern California
DepartmentMolecular Microbiology and Immunology
AddressNRT 5505 1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 7930
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of Microbiome Sodium Butyrate in regulation of ILC2 dependent airway hyperreactivity
    NIH/NIAID R21AI132084May 18, 2017 - Apr 30, 2019
    Role: Principal Investigator
    The function of CRAC channels in airway inflammation
    NIH/NIAID R21AI109059Jan 1, 2016 - Dec 31, 2017
    Role: Co-Principal Investigator
    Genetic and Environmental Determinants of Asthma Endophenotypes
    NIH/NIEHS R01ES025786Aug 1, 2015 - Apr 30, 2020
    Role: Co-Principal Investigator
    Air pollution, immune modulation of adipose tissue and type-2 diabetes risk factors
    NIH/NIEHS R21ES024707Jul 10, 2014 - Jun 30, 2016
    Role: Co-Principal Investigator
    INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMA
    NIH/NIEHS R01ES021801Aug 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator
    Role of NKT cells in airway hyperreactivity &tolerance
    NIH/NIAID R01AI066020Sep 20, 2007 - Aug 31, 2014
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rao P, Wen X, Lo JH, Kim S, Li X, Chen S, Feng X, Akbari O, Yuan W. Herpes simplex virus-1 specifically targets human CD1d antigen presentation to enhance its pathogenicity. J Virol. 2018 Sep 05. PMID: 30185591.
      View in: PubMed
    2. Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Camacho V, Minami K, Nian Y, Koduru S, El Fatimy R, Ghiran I, Trachtenberg AJ, de la Fuente MA, Azuma H, Akbari O, Tullius SG, Vasudevan A, Elkhal A. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. J Allergy Clin Immunol. 2018 Feb 20. PMID: 29470999.
      View in: PubMed
    3. Ogasawara N, Poposki JA, Klingler AI, Tan BK, Weibman AR, Hulse KE, Stevens WW, Peters AT, Grammer LC, Schleimer RP, Welch KC, Smith SS, Conley DB, Raviv JR, Soroosh P, Akbari O, Himi T, Kern RC, Kato A. IL-10, TGF-ß, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol. 2018 Mar; 141(3):1147-1151.e8. PMID: 29074458.
      View in: PubMed
    4. Qin X, Hoda MN, Susin C, Wheeler JN, Marshall B, Perry L, Saad N, Yin L, Elsayed R, Elsalanty M, Abdelsayed R, Yu JC, Dhandapani KM, Akbari O, Mozaffari MS, Baban B. Increased Innate Lymphoid Cells in Periodontal Tissue of the Murine Model of Periodontitis: The Role of AMP-Activated Protein Kinase and Relevance for the Human Condition. Front Immunol. 2017; 8:922. PMID: 28861078.
      View in: PubMed
    5. Bensman TJ, Jayne JG, Sun M, Kimura E, Meinert J, Wang JC, Schaal JB, Tran D, Rao AP, Akbari O, Selsted ME, Beringer PM. Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation. Antimicrob Agents Chemother. 2017 08; 61(8). PMID: 28559270.
      View in: PubMed
    6. Maazi H, Akbari O. Type two innate lymphoid cells: the Janus cells in health and disease. Immunol Rev. 2017 07; 278(1):192-206. PMID: 28658553.
      View in: PubMed
    7. Maazi H, Banie H, Aleman Muench GR, Patel N, Wang B, Sankaranarayanan I, Bhargava V, Sato T, Lewis G, Cesaroni M, Karras J, Das A, Soroosh P, Akbari O. Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell-mediated airway hyperreactivity. J Allergy Clin Immunol. 2018 Mar; 141(3):893-905.e6. PMID: 28579374.
      View in: PubMed
    8. Poposki JA, Klingler AI, Tan BK, Soroosh P, Banie H, Lewis G, Hulse KE, Stevens WW, Peters AT, Grammer LC, Schleimer RP, Welch KC, Smith SS, Conley DB, Raviv JR, Karras JG, Akbari O, Kern RC, Kato A. Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps. Immun Inflamm Dis. 2017 Sep; 5(3):233-243. PMID: 28474861.
      View in: PubMed
    9. Maazi H, Suzuki Y, Jung J, Akbari O. Reply. J Allergy Clin Immunol. 2017 Feb; 139(2):712-713. PMID: 27847142.
      View in: PubMed
    10. Galle-Treger L, Suzuki Y, Patel N, Sankaranarayanan I, Aron JL, Maazi H, Chen L, Akbari O. Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity. Nat Commun. 2016 Oct 18; 7:13202. PMID: 27752043.
      View in: PubMed
    11. Rigas D, Lewis G, Aron JL, Wang B, Banie H, Sankaranarayanan I, Galle-Treger L, Maazi H, Lo R, Freeman GJ, Sharpe AH, Soroosh P, Akbari O. Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction. J Allergy Clin Immunol. 2017 May; 139(5):1468-1477.e2. PMID: 27717665.
      View in: PubMed
    12. Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJGM, Aswad DW, Laird-Offringa IA. Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. J Neuroimmunol. 2016 10 15; 299:70-78. PMID: 27725125.
      View in: PubMed
    13. Simmerman E, Qin X, Marshall B, Perry L, Cai L, Wang T, Yu J, Akbari O, Baban B. Innate lymphoid cells: a paradigm for low SSI in cleft lip repair. J Surg Res. 2016 Oct; 205(2):312-317. PMID: 27664878.
      View in: PubMed
    14. Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P. I?B Kinase e Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Rep. 2016 07 12; 16(2):405-418. PMID: 27346349.
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    15. Tian Y, Kuo CF, Akbari O, Ou JH. Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016 05 17; 44(5):1204-14. PMID: 27156385; PMCID: PMC4871724 [Available on 05/17/17].
      View in: PubMed, PubMed Central
    16. Gyllenhammer LE, Lam J, Alderete TL, Allayee H, Akbari O, Katkhouda N, Goran MI. Lower omental t-regulatory cell count is associated with higher fasting glucose and lower ß-cell function in adults with obesity. Obesity (Silver Spring). 2016 06; 24(6):1274-82. PMID: 27133873; PMCID: PMC4882248 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    17. Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, Golub ET, Sharp GB, Kovacs A. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):172-80. PMID: 26761519; PMCID: PMC4712709 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    18. Suzuki Y, Maazi H, Sankaranarayanan I, Lam J, Khoo B, Soroosh P, Barbers RG, James Ou JH, Jung JU, Akbari O. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol. 2016 May; 137(5):1382-1389.e9. PMID: 26589586; PMCID: PMC4860134 [Available on 05/01/17].
      View in: PubMed, PubMed Central
    19. Maazi H, Akbari O. ICOS regulates ILC2s in asthma. Oncotarget. 2015 Sep 22; 6(28):24584-5. PMID: 26309088; PMCID: PMC4694773.
      View in: PubMed, PubMed Central
    20. Wen X, Kim S, Xiong R, Li M, Lawrenczyk A, Huang X, Chen SY, Rao P, Besra GS, Dellabona P, Casorati G, Porcelli SA, Akbari O, Exley MA, Yuan W. A Subset of CD8aß+ Invariant NKT Cells in a Humanized Mouse Model. J Immunol. 2015 Aug 15; 195(4):1459-69. PMID: 26157173; PMCID: PMC4530047.
      View in: PubMed, PubMed Central
    21. Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O. ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity. 2015 Mar 17; 42(3):538-51. PMID: 25769613; PMCID: PMC4366271.
      View in: PubMed, PubMed Central
    22. Mott KR, Maazi H, Allen SJ, Zandian M, Matundan H, Ghiasi YN, Sharifi BG, Underhill D, Akbari O, Ghiasi H. Batf3 deficiency is not critical for the generation of CD8a? dendritic cells. Immunobiology. 2015 Apr; 220(4):518-24. PMID: 25468565; PMCID: PMC4355210.
      View in: PubMed, PubMed Central
    23. Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H. Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. PLoS One. 2014; 9(1):e87617. PMID: 24475315; PMCID: PMC3903765.
      View in: PubMed, PubMed Central
    24. Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O. Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. PLoS One. 2013; 8(3):e59599. PMID: 23555047; PMCID: PMC3598698.
      View in: PubMed, PubMed Central
    25. Kerzerho J, Maazi H, Speak AO, Szely N, Lombardi V, Khoo B, Geryak S, Lam J, Soroosh P, Van Snick J, Akbari O. Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity. J Allergy Clin Immunol. 2013 Apr; 131(4):1048-57, 1057.e1-2. PMID: 23174661; PMCID: PMC3651917.
      View in: PubMed, PubMed Central
    26. Rehan VK, Liu J, Naeem E, Tian J, Sakurai R, Kwong K, Akbari O, Torday JS. Perinatal nicotine exposure induces asthma in second generation offspring. BMC Med. 2012 Oct 30; 10:129. PMID: 23106849; PMCID: PMC3568737.
      View in: PubMed, PubMed Central
    27. Liu J, Naeem E, Tian J, Lombardi V, Kwong K, Akbari O, Torday JS, Rehan VK. Sex-specific perinatal nicotine-induced asthma in rat offspring. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):53-62. PMID: 23002101; PMCID: PMC3547089.
      View in: PubMed, PubMed Central
    28. Kerzerho J, Yu ED, Barra CM, Alari-Pahissa E, Alari-Pahisa E, Girardi E, Harrak Y, Lauzurica P, Llebaria A, Zajonc DM, Akbari O, Castaño AR. Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. J Immunol. 2012 Mar 01; 188(5):2254-65. PMID: 22301545; PMCID: PMC3288653.
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    29. Kerzerho J, Wunsch D, Szely N, Meyer HA, Lurz L, Röse L, Wahn U, Akbari O, Stock P. Effects of systemic versus local administration of corticosteroids on mucosal tolerance. J Immunol. 2012 Jan 01; 188(1):470-6. PMID: 22105997; PMCID: PMC3253659.
      View in: PubMed, PubMed Central
    30. Li M, Krishnaveni MS, Li C, Zhou B, Xing Y, Banfalvi A, Li A, Lombardi V, Akbari O, Borok Z, Minoo P. Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan; 121(1):277-87. PMID: 21135509; PMCID: PMC3007138.
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    31. Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH. TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. J Immunol. 2010 Dec 01; 185(11):6839-49. PMID: 21037090; PMCID: PMC3153437.
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    32. Lombardi V, Stock P, Singh AK, Kerzerho J, Yang W, Sullivan BA, Li X, Shiratsuchi T, Hnatiuk NE, Howell AR, Yu KO, Porcelli SA, Tsuji M, Kronenberg M, Wilson SB, Akbari O. A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. J Immunol. 2010 Feb 15; 184(4):2107-15. PMID: 20083656; PMCID: PMC2845715.
      View in: PubMed, PubMed Central
    33. Lombardi V, Akbari O. Dendritic cell modulation as a new interventional approach for the treatment of asthma. Drug News Perspect. 2009 Oct; 22(8):445-51. PMID: 20016853; PMCID: PMC2845716.
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    34. Lombardi V, Singh AK, Akbari O. The role of costimulatory molecules in allergic disease and asthma. Int Arch Allergy Immunol. 2010; 151(3):179-89. PMID: 19786798; PMCID: PMC2837887.
      View in: PubMed, PubMed Central
    35. Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, Sharpe AH, Umetsu DT, Dekruyff RH. PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. Mucosal Immunol. 2010 Jan; 3(1):81-91. PMID: 19741598; PMCID: PMC2845714.
      View in: PubMed, PubMed Central
    36. Stock P, Lombardi V, Kohlrautz V, Akbari O. Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 2009 Apr 15; 182(8):5116-22. PMID: 19342692; PMCID: PMC2837931.
      View in: PubMed, PubMed Central
    37. Matangkasombut P, Marigowda G, Ervine A, Idris L, Pichavant M, Kim HY, Yasumi T, Wilson SB, DeKruyff RH, Faul JL, Israel E, Akbari O, Umetsu DT. Natural killer T cells in the lungs of patients with asthma. J Allergy Clin Immunol. 2009 May; 123(5):1181-5. PMID: 19356791; PMCID: PMC2734957.
      View in: PubMed, PubMed Central
    38. Koh YI, Kim HY, Meyer EH, Pichavant M, Akbari O, Yasumi T, Savage PB, DeKruyff RH, Umetsu DT. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice. J Immunol. 2008 Oct 01; 181(7):4560-4569. PMID: 18802058; PMCID: PMC4884641.
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    39. Exley MA, Hou R, Shaulov A, Tonti E, Dellabona P, Casorati G, Akbari O, Akman HO, Greenfield EA, Gumperz JE, Boyson JE, Balk SP, Wilson SB. Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop. Eur J Immunol. 2008 Jun; 38(6):1756-66. PMID: 18493987; PMCID: PMC2864538.
      View in: PubMed, PubMed Central
    40. Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol. 2008 Apr 15; 180(8):5448-56. PMID: 18390727; PMCID: PMC2835525.
      View in: PubMed, PubMed Central
    41. Stock P, Akbari O. Recent advances in the role of NKT cells in allergic diseases and asthma. Curr Allergy Asthma Rep. 2008 Apr; 8(2):165-70. PMID: 18417059.
      View in: PubMed
    42. Akbari O, Faul JL, Umetsu DT. Invariant natural killer T cells in obstructive pulmonary diseases. N Engl J Med. 2007 Jul 12; 357(2):193-4; author reply 194-5. PMID: 17625134.
      View in: PubMed
    43. Akbari O, Faul JL, Hoyte EG, Berry GJ, Wahlström J, Kronenberg M, DeKruyff RH, Umetsu DT. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med. 2006 Mar 16; 354(11):1117-29. PMID: 16540612.
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    44. Meyer EH, Goya S, Akbari O, Berry GJ, Savage PB, Kronenberg M, Nakayama T, DeKruyff RH, Umetsu DT. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2782-7. PMID: 16478801; PMCID: PMC1413796.
      View in: PubMed, PubMed Central
    45. Stock P, Akbari O, DeKruyff RH, Umetsu DT. Respiratory tolerance is inhibited by the administration of corticosteroids. J Immunol. 2005 Dec 01; 175(11):7380-7. PMID: 16301645.
      View in: PubMed
    46. Umetsu SE, Lee WL, McIntire JJ, Downey L, Sanjanwala B, Akbari O, Berry GJ, Nagumo H, Freeman GJ, Umetsu DT, DeKruyff RH. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol. 2005 May; 6(5):447-54. PMID: 15793575.
      View in: PubMed
    47. Akbari O, Umetsu DT. Role of regulatory dendritic cells in allergy and asthma. Curr Allergy Asthma Rep. 2005 Jan; 5(1):56-61. PMID: 15659264.
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    48. Akbari O, Umetsu DT. Role of regulatory dendritic cells in allergy and asthma. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):533-8. PMID: 15640695.
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    49. Stock P, Akbari O, Berry G, Freeman GJ, Dekruyff RH, Umetsu DT. Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat Immunol. 2004 Nov; 5(11):1149-56. PMID: 15448689.
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    50. Stock P, Kallinich T, Akbari O, Quarcoo D, Gerhold K, Wahn U, Umetsu DT, Hamelmann E. CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation. Eur J Immunol. 2004 Jul; 34(7):1817-27. PMID: 15214030.
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    51. Akbari O, Stock P, DeKruyff RH, Umetsu DT. Role of regulatory T cells in allergy and asthma. Curr Opin Immunol. 2003 Dec; 15(6):627-33. PMID: 14630195.
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    52. Umetsu DT, Akbari O, Dekruyff RH. Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol. 2003 Sep; 112(3):480-7; quiz 488. PMID: 13679803.
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    53. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med. 2003 May; 9(5):582-8. PMID: 12669034.
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    54. Akbari O, Stock P, DeKruyff RH, Umetsu DT. Mucosal tolerance and immunity: regulating the development of allergic disease and asthma. Int Arch Allergy Immunol. 2003 Feb; 130(2):108-18. PMID: 12673064.
      View in: PubMed
    55. Oh JW, Seroogy CM, Meyer EH, Akbari O, Berry G, Fathman CG, Dekruyff RH, Umetsu DT. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol. 2002 Sep; 110(3):460-8. PMID: 12209095.
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    56. Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH. Asthma: an epidemic of dysregulated immunity. Nat Immunol. 2002 Aug; 3(8):715-20. PMID: 12145657.
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    57. Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32. PMID: 12145647.
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