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Omid Akbari, PhD

Title(s)Professor of Molecular Microbiology & Immunology and Medicine
SchoolKeck School of Medicine of Usc
AddressNRT 5505 1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 7930
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    Collapse Biography 
    Collapse awards and honors
    USC2025  - 2030Omid Akbari
    Stanford University2001  - 2003American Lung Association award
    Stanford University and Harvard Medical School2003  - 2005American Lung Association Grant Award
    Stanford University2003Pharmacia Research Foundation Award for the best research in the field of Immunology, Stockholm
    Stanford University2004Pharmacia Research Foundation Award for the best research in the field of Immunology, Amsterdam
    Harvard Medical School2005Pharmacia Research Foundation Award for the best research in the field of Immunology, Munich
    Harvard Medical School2005Henning Lowenstein Award for the best research in the field of Allergy and Immunology, Munich
    Harvard Medical School2007  - 2008Eleanor & Miles Shore Career Development Award
    Harvard Medical School2007  - 2008Children’s Hospital of Boston Career Development Award
    University of Southern California 2012  - 2013Ideas Empowered Award
    University of Southern California2017  - 2018National Academy of Inventors Award
    University of Southern California2023Keck School of Medicine Dean’s award for scholarship

    Collapse Overview 
    Collapse overview
    We are cellular and molecular immunologists dedicated to advancing the understanding of the immune system. Our laboratory focuses on characterizing both innate and acquired immune responses, uncovering the mechanisms that regulate them, and investigating how they contribute to inflammatory diseases. We manipulate cell signaling pathways, costimulatory molecules, and cellular energy sources to modulate immune function and improve human health. Ultimately, our goal is to identify precise strategies to harness and control these responses for therapeutic benefit.

    Collapse Research 
    Collapse research activities and funding
    Study the link of autophagy dysfunction to allergic and neutrophilic asthma onset
    NIH R01HL151493Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Induction of cells and pathways that promote respiratory tolerance in allergic asthma
    NIH R01HL144790Sep 1, 2019 - Aug 31, 2023
    Role: Principal Investigator
    Maternal effect on offspring immunity against hepatitis B virus
    NIH R01AI145813Jul 3, 2019 - Jun 30, 2024
    Role: Co-Principal Investigator
    Role of Microbiome Sodium Butyrate in regulation of ILC2 dependent airway hyperreactivity
    NIH R21AI132084May 18, 2017 - Apr 30, 2020
    Role: Principal Investigator
    The function of CRAC channels in airway inflammation
    NIH R21AI109059Jan 1, 2016 - Dec 31, 2017
    Role: Co-Principal Investigator
    Genetic and Environmental Determinants of Asthma Endophenotypes
    NIH R01ES025786Aug 1, 2015 - Apr 30, 2021
    Role: Co-Principal Investigator
    Air pollution, immune modulation of adipose tissue and type-2 diabetes risk factors
    NIH R21ES024707Jul 10, 2014 - Jun 30, 2018
    Role: Co-Principal Investigator
    INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMA
    NIH R01ES021801Aug 1, 2012 - Oct 31, 2019
    Role: Co-Principal Investigator
    Role of NKT cells in airway hyperreactivity &tolerance
    NIH R01AI066020Sep 20, 2007 - Aug 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Expanding Role of ILC2s in Allergic Airways Disease. Allergy. 2025 Sep 02. Cain J, Hurrell B, Akbari O. PMID: 40891582.
      View in: PubMed   Mentions:    Fields:    
    2. HPV16 E6 and E7 expressing cancer cells suppress the antitumor immune response by upregulating KLF2-mediated IL-23 expression in macrophages. J Immunother Cancer. 2025 Aug 19; 13(8). Prins R, Fernandez DJ, Akbari O, Da Silva DM, Kast WM. PMID: 40829900; PMCID: PMC12366621.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Targeting CD48 Ameliorates ILC2-mediated Airway Hyperreactivity by Disrupting the PKCβ Pathway. Am J Respir Cell Mol Biol. 2025 Jul 28. Sakano K, Sakano Y, Hurrell BP, Kazemi MH, Li X, Shen S, Akbari O. PMID: 40720762.
      View in: PubMed   Mentions: 1     Fields:    
    4. ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis. J Clin Invest. 2025 Sep 16; 135(18). Sakano Y, Sakano K, Hurrell BP, Kazemi MH, Li X, Shen S, Akbari O. PMID: 40627441; PMCID: PMC12435846.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Multiple chemical sensitivity (MCS) validity, prevalence, tools and interventions: systematic review protocol. BMJ Open. 2025 May 08; 15(5):e088136. Hempel S, Zhang D, Robinson KA, Yagyu S, Miles J, Motala A, Tolentino D, Akbari O, Danz M, Johnston J. PMID: 40345685; PMCID: PMC12067775.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. BTLA agonist attenuates Th17-driven inflammation in a mouse model of steroid-resistant asthma. Front Immunol. 2025; 16:1552394. Quach C, Li X, Shafiei-Jahani P, Li M, Shen S, Helou DG, Hurrell BP, Soroosh P, Akbari O. PMID: 40226621; PMCID: PMC11986467.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Integrated workflow for analysis of immune enriched spatial proteomic data with IMmuneCite. Sci Rep. 2025 Mar 19; 15(1):9394. Barbetta A, Bangerth S, Lee JTC, Rocque B, Roussos Torres ET, Kohli R, Akbari O, Emamaullee J. PMID: 40102469; PMCID: PMC11920390.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. FOXO1 pathway activation by VISTA immune checkpoint restrains pulmonary ILC2 functions. J Clin Invest. 2025 Jan 02; 135(4). Kazemi MH, Momeni-Varposhti Z, Li X, Hurrell BP, Sakano Y, Shen S, Shafiei-Jahani P, Sakano K, Akbari O. PMID: 39745792; PMCID: PMC11827891.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Sensory neurons regulate stimulus-dependent humoral immunity in mouse models of bacterial infection and asthma. Nat Commun. 2024 10 16; 15(1):8914. Aguilar D, Zhu F, Millet A, Millet N, Germano P, Pisegna J, Akbari O, Doherty TA, Swidergall M, Jendzjowsky N. PMID: 39414787; PMCID: PMC11484968.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism. Cell Mol Immunol. 2024 Oct; 21(10):1158-1174. Sakano Y, Sakano K, Hurrell BP, Shafiei-Jahani P, Kazemi MH, Li X, Shen S, Barbers R, Akbari O. PMID: 39160226; PMCID: PMC11442993.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. Sensory neurons regulate stimulus-dependent humoral immunity. bioRxiv. 2024 Aug 13. Aguilar D, Zhu F, Millet A, Millet N, Germano P, Pisegna J, Akbari O, Doherty TA, Swidergall M, Jendzjowsky N. PMID: 38260709; PMCID: PMC10802321.
      View in: PubMed   Mentions:
    12. IMmuneCite: an integrated workflow for analysis of immune enriched spatial proteomic data. Res Sq. 2024 Jul 09. Barbetta A, Bangerth S, Lee JTC, Rocque B, Roussos Torres ET, Kohli R, Akbari O, Emamaullee J. PMID: 39041033; PMCID: PMC11261960.
      View in: PubMed   Mentions:
    13. CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus. Cell Rep. 2024 07 23; 43(7):114434. Shafiei-Jahani P, Yan S, Kazemi MH, Li X, Akbari A, Sakano K, Sakano Y, Hurrell BP, Akbari O. PMID: 38963763; PMCID: PMC11317174.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function. Sci Transl Med. 2024 05 08; 16(746):eadk4728. Hurrell BP, Sakano Y, Shen S, Helou DG, Li M, Shafiei-Jahani P, Kazemi MH, Sakano K, Li X, Quach C, Barbers R, Akbari O. PMID: 38718131.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    15. Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection. Sci Adv. 2024 Apr 12; 10(15):eadm8841. Barbetta A, Rocque B, Bangerth S, Street K, Weaver C, Chopra S, Kim J, Sher L, Gaudilliere B, Akbari O, Kohli R, Emamaullee J. PMID: 38608023; PMCID: PMC11014454.
      View in: PubMed   Mentions: 4     Fields:    
    16. Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity. J Exp Med. 2024 May 06; 221(5). Hurrell BP, Shen S, Li X, Sakano Y, Kazemi MH, Quach C, Shafiei-Jahani P, Sakano K, Ghiasi H, Akbari O. PMID: 38530239; PMCID: PMC10965393.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages. PLoS Pathog. 2024 Mar; 20(3):e1012079. Li Y, Wu C, Lee J, Ning Q, Lim J, Eoh H, Wang S, Hurrell BP, Akbari O, Ou JJ. PMID: 38466743; PMCID: PMC10957081.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Technical optimization of spatially resolved single-cell transcriptomic datasets to study clinical liver disease. Sci Rep. 2024 02 13; 14(1):3612. Rocque B, Guion K, Singh P, Bangerth S, Pickard L, Bhattacharjee J, Eguizabal S, Weaver C, Chopra S, Zhou S, Kohli R, Sher L, Akbari O, Ekser B, Emamaullee JA. PMID: 38351241; PMCID: PMC10864257.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity. J Allergy Clin Immunol. 2024 May; 153(5):1406-1422.e6. Sakano Y, Sakano K, Hurrell BP, Helou DG, Shafiei-Jahani P, Kazemi MH, Li X, Shen S, Hilser JR, Hartiala JA, Allayee H, Barbers R, Akbari O. PMID: 38244725.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models. Nat Commun. 2023 09 26; 14(1):5989. Howard E, Hurrell BP, Helou DG, Shafiei-Jahani P, Hasiakos S, Painter J, Srikanth S, Gwack Y, Akbari O. PMID: 37752127; PMCID: PMC10522697.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct. BMJ Open. 2023 09 22; 13(9):e072098. Hempel S, Danz M, Robinson KA, Bolshakova M, Rodriguez J, Mears A, Pham C, Yagyu S, Motala A, Tolentino D, Akbari O, Johnston J. PMID: 37739463; PMCID: PMC10533706.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    22. LAIR-1 limits macrophage activation in acute inflammatory lung injury. Mucosal Immunol. 2023 12; 16(6):788-800. Helou DG, Quach C, Hurrell BP, Li X, Li M, Akbari A, Shen S, Shafiei-Jahani P, Akbari O. PMID: 37634572; PMCID: PMC10842758.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    23. Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome. Cell Rep. 2023 08 29; 42(8):112990. Quach C, Helou DG, Li M, Hurrell BP, Howard E, Shafiei-Jahani P, Soroosh P, Ou JJ, Razani B, Rehan V, Akbari O. PMID: 37590140; PMCID: PMC10510741.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection. Res Sq. 2023 Jul 03. Barbetta A, Rocque B, Bangerth S, Street K, Weaver C, Chopra S, Kim J, Sher L, Gaudilliere B, Akbari O, Kohli R, Emamaullee J. PMID: 37461437; PMCID: PMC10350170.
      View in: PubMed   Mentions:
    25. Altered Tumor Necrosis Factor Response in Neurologic Postacute SARS-CoV-2 Syndrome. J Interferon Cytokine Res. 2023 07; 43(7):307-313. Allan-Blitz LT, Goodrich J, Hu H, Akbari O, Klausner JD. PMID: 37384921; PMCID: PMC10354723.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Unique immune and inflammatory cytokine profiles may define long COVID syndrome. Clin Exp Med. 2023 Oct; 23(6):2925-2930. Allan-Blitz LT, Akbari O, Kojima N, Saavedra E, Chellamuthu P, Denny N, MacMullan MA, Hess V, Shacreaw M, Brobeck M, Turner F, Slepnev VI, Ibrayeva A, Klausner JD. PMID: 37061998; PMCID: PMC10105906.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    27. Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. Nat Commun. 2023 04 11; 14(1):2045. Choi YJ, Yoo JS, Jung K, Rice L, Kim D, Zlojutro V, Frimel M, Madden E, Choi UY, Foo SS, Choi Y, Jiang Z, Johnson H, Kwak MJ, Kang S, Hong B, Seo GJ, Kim S, Lee SA, Amini-Bavil-Olyaee S, Maazi H, Akbari O, Asosingh K, Jung JU. PMID: 37041174; PMCID: PMC10090139.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    28. PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability. Nat Commun. 2022 08 31; 13(1):5118. Hurrell BP, Helou DG, Howard E, Painter JD, Shafiei-Jahani P, Sharpe AH, Akbari O. PMID: 36045140; PMCID: PMC9433378.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    29. Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells. J Allergy Clin Immunol. 2023 02; 151(2):526-538.e8. Helou DG, Quach C, Fung M, Painter JD, Hurrell BP, Eddie Loh YH, Howard E, Shafiei-Jahani P, Soroosh P, Sharpe AH, Akbari O. PMID: 35963455; PMCID: PMC9905221.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Analysis of the interplay between hepatitis B virus-positive hepatocytes and Kupffer cells ex vivo using mice as a model. STAR Protoc. 2022 06 17; 3(2):101364. Li Y, Lee J, Helou DG, Akbari O, Ou JJ. PMID: 35573478; PMCID: PMC9097500.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    31. Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection. Front Immunol. 2022; 13:831103. Ung N, Goldbeck C, Man C, Hoeflich J, Sun R, Barbetta A, Matasci N, Katz J, Lee JSH, Chopra S, Asgharzadeh S, Warren M, Sher L, Kohli R, Akbari O, Genyk Y, Emamaullee J. PMID: 35432320; PMCID: PMC9009043.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Near-roadway air pollution, immune cells and adipokines among obese young adults. Environ Health. 2022 03 19; 21(1):36. Rahman MM, Liu FF, Eckel SP, Sankaranarayanan I, Shafiei-Jahani P, Howard E, Baronikian L, Sattler F, Lurmann FW, Allayee H, Akbari O, McConnell R. PMID: 35305663; PMCID: PMC8933931.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    33. Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nat Commun. 2022 03 17; 13(1):1440. Galle-Treger L, Helou DG, Quach C, Howard E, Hurrell BP, Muench GRA, Shafiei-Jahani P, Painter JD, Iorga A, Dara L, Emamaullee J, Golden-Mason L, Rosen HR, Soroosh P, Akbari O. PMID: 35301333; PMCID: PMC8931085.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    34. Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity. J Allergy Clin Immunol. 2022 05; 149(5):1628-1642.e10. Hurrell BP, Helou DG, Shafiei-Jahani P, Howard E, Painter JD, Quach C, Akbari O. PMID: 34673048; PMCID: PMC9013728.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    35. PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma. Front Immunol. 2021; 12:733136. Howard E, Hurrell BP, Helou DG, Quach C, Painter JD, Shafiei-Jahani P, Fung M, Gill PS, Soroosh P, Sharpe AH, Akbari O. PMID: 34531874; PMCID: PMC8438316.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    36. Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes. Front Immunol. 2021; 12:727008. Painter JD, Akbari O. PMID: 34489979; PMCID: PMC8416625.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    37. Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation. mBio. 2021 08 31; 12(4):e0117621. Matundan HH, Jaggi U, Yu J, Akbari O, Ghiasi H. PMID: 34281386; PMCID: PMC8406230.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    38. Creation of a Single Cell RNASeq Meta-Atlas to Define Human Liver Immune Homeostasis. Front Immunol. 2021; 12:679521. Rocque B, Barbetta A, Singh P, Goldbeck C, Helou DG, Loh YE, Ung N, Lee J, Akbari O, Emamaullee J. PMID: 34335581; PMCID: PMC8322955.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    39. LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. J Allergy Clin Immunol. 2022 01; 149(1):223-236.e6. Helou DG, Shafiei-Jahani P, Hurrell BP, Painter JD, Quach C, Howard E, Akbari O. PMID: 34144112; PMCID: PMC8674385.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    40. CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma. Nat Commun. 2021 05 05; 12(1):2526. Shafiei-Jahani P, Helou DG, Hurrell BP, Howard E, Quach C, Painter JD, Galle-Treger L, Li M, Loh YE, Akbari O. PMID: 33953190; PMCID: PMC8100131.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    41. CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation. Mucosal Immunol. 2021 07; 14(4):899-911. Shafiei-Jahani P, Helou DG, Hurrell BP, Galle-Treger L, Howard E, Quach C, Painter JD, Fung M, Lo R, Allayee H, Akbari O. PMID: 33731828; PMCID: PMC8225558.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells. J Virol. 2021 01 28; 95(4). Hirose S, Kato M, Tormanen K, Shafiei Jahani P, Akbari O, Ghiasi H. PMID: 33208451; PMCID: PMC7851570.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    43. AMPK induces regulatory innate lymphoid cells after traumatic brain injury. JCI Insight. 2021 01 11; 6(1). Baban B, Braun M, Khodadadi H, Ward A, Alverson K, Malik A, Nguyen K, Nazarian S, Hess DC, Forseen S, Post AF, Vale FL, Vender JR, Hoda MN, Akbari O, Vaibhav K, Dhandapani KM. PMID: 33427206; PMCID: PMC7821592.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity. Front Immunol. 2020; 11:542818. Hurrell BP, Howard E, Galle-Treger L, Helou DG, Shafiei-Jahani P, Painter JD, Akbari O. PMID: 33193309; PMCID: PMC7662114.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    45. DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus. Nat Commun. 2020 09 18; 11(1):4718. Shafiei-Jahani P, Hurrell BP, Galle-Treger L, Helou DG, Howard E, Painter J, Lo R, Lewis G, Soroosh P, Akbari O. PMID: 32948777; PMCID: PMC7501856.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    46. Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis. iScience. 2020 Oct 23; 23(10):101549. Hirose S, Jahani PS, Wang S, Jaggi U, Tormanen K, Yu J, Kato M, Akbari O, Ghiasi H. PMID: 33083718; PMCID: PMC7522755.
      View in: PubMed   Mentions: 16  
    47. IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity. J Allergy Clin Immunol. 2021 04; 147(4):1281-1295.e5. Howard E, Lewis G, Galle-Treger L, Hurrell BP, Helou DG, Shafiei-Jahani P, Painter JD, Muench GA, Soroosh P, Akbari O. PMID: 32905799.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    48. Feasibility of quantifying change in immune white cells in abdominal adipose tissue in response to an immune modulator in clinical obesity. PLoS One. 2020; 15(9):e0237496. Sattler FR, Mert M, Sankaranarayanan I, Mack WJ, Galle-Treger L, Gonzalez E, Baronikian L, Lee K, Jahani PS, Hodis HN, Dieli-Conwright C, Akbari O. PMID: 32881912; PMCID: PMC7470412.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsCTClinical Trials
    49. PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity. Nat Commun. 2020 08 10; 11(1):3998. Helou DG, Shafiei-Jahani P, Lo R, Howard E, Hurrell BP, Galle-Treger L, Painter JD, Lewis G, Soroosh P, Sharpe AH, Akbari O. PMID: 32778730; PMCID: PMC7417739.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    50. Perinatal nicotine exposure-induced transgenerational asthma: Effects of reexposure in F1 gestation. FASEB J. 2020 09; 34(9):11444-11459. Liu J, Yu C, Doherty TM, Akbari O, Allard P, Rehan VK. PMID: 32654256; PMCID: PMC7839813.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    51. Role of Autophagy in Lung Inflammation. Front Immunol. 2020; 11:1337. Painter JD, Galle-Treger L, Akbari O. PMID: 32733448; PMCID: PMC7358431.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    52. Repopulation of T, B, and NK cells following alemtuzumab treatment in relapsing-remitting multiple sclerosis. J Neuroinflammation. 2020 Jun 15; 17(1):189. Gilmore W, Lund BT, Li P, Levy AM, Kelland EE, Akbari O, Groshen S, Cen SY, Pelletier D, Weiner LP, Javed A, Dunn JE, Traboulsee AL. PMID: 32539719; PMCID: PMC7296935.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCellsCTClinical Trials
    53. Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma. Nat Commun. 2020 04 15; 11(1):1776. Han Y, Jia Q, Jahani PS, Hurrell BP, Pan C, Huang P, Gukasyan J, Woodward NC, Eskin E, Gilliland FD, Akbari O, Hartiala JA, Allayee H. PMID: 32296059; PMCID: PMC7160128.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    54. TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity. Cell Rep. 2019 12 24; 29(13):4509-4524.e5. Hurrell BP, Galle-Treger L, Jahani PS, Howard E, Helou DG, Banie H, Soroosh P, Akbari O. PMID: 31875557; PMCID: PMC6940205.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
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    56. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019 12 12; 10(1):5681. Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, Sands N, O'Connell D, Restrepo-Vassalli S, Chai B, Nemecio D, Punj V, Akbari O, Idos GE, Mumenthaler SM, Wu N, Martin SE, Hagiya A, Hicks J, Cui H, Liang C. PMID: 31831743; PMCID: PMC6908726.
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    59. Immunologic benefit of maternal donors in pediatric living donor liver transplantation. Pediatr Transplant. 2019 11; 23(7):e13560. Kim MH, Akbari O, Genyk Y, Kohli R, Emamaullee J. PMID: 31402535.
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    61. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance. Nat Commun. 2019 04 12; 10(1):1693. Li S, Song Y, Quach C, Guo H, Jang GB, Maazi H, Zhao S, Sands NA, Liu Q, In GK, Peng D, Yuan W, Machida K, Yu M, Akbari O, Hagiya A, Yang Y, Punj V, Tang L, Liang C. PMID: 30979895; PMCID: PMC6461621.
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    62. Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice. Sci Rep. 2019 02 12; 9(1):1816. Woodward NC, Crow AL, Zhang Y, Epstein S, Hartiala J, Johnson R, Kocalis H, Saffari A, Sankaranarayanan I, Akbari O, Ramanathan G, Araujo JA, Finch CE, Bouret SG, Sioutas C, Morgan TE, Allayee H. PMID: 30755631; PMCID: PMC6372675.
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    65. Herpes Simplex Virus 1 Specifically Targets Human CD1d Antigen Presentation To Enhance Its Pathogenicity. J Virol. 2018 11 15; 92(22). Rao P, Wen X, Lo JH, Kim S, Li X, Chen S, Feng X, Akbari O, Yuan W. PMID: 30185591; PMCID: PMC6206489.
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    66. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. J Allergy Clin Immunol. 2018 12; 142(6):1894-1908.e7. Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Camacho V, Minami K, Nian Y, Koduru S, El Fatimy R, Ghiran I, Trachtenberg AJ, de la Fuente MA, Azuma H, Akbari O, Tullius SG, Vasudevan A, Elkhal A. PMID: 29470999; PMCID: PMC6454881.
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    68. Increased Innate Lymphoid Cells in Periodontal Tissue of the Murine Model of Periodontitis: The Role of AMP-Activated Protein Kinase and Relevance for the Human Condition. Front Immunol. 2017; 8:922. Qin X, Hoda MN, Susin C, Wheeler JN, Marshall B, Perry L, Saad N, Yin L, Elsayed R, Elsalanty M, Abdelsayed R, Yu JC, Dhandapani KM, Akbari O, Mozaffari MS, Baban B. PMID: 28861078; PMCID: PMC5559469.
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    69. Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation. Antimicrob Agents Chemother. 2017 08; 61(8). Bensman TJ, Jayne JG, Sun M, Kimura E, Meinert J, Wang JC, Schaal JB, Tran D, Rao AP, Akbari O, Selsted ME, Beringer PM. PMID: 28559270; PMCID: PMC5527632.
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    77. IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Rep. 2016 07 12; 16(2):405-418. Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P. PMID: 27346349; PMCID: PMC5293007.
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    78. Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016 05 17; 44(5):1204-14. Tian Y, Kuo CF, Akbari O, Ou JH. PMID: 27156385; PMCID: PMC4871724.
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    80. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):172-80. Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, Golub ET, Sharp GB, Kovacs A. PMID: 26761519; PMCID: PMC4712709.
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    81. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol. 2016 05; 137(5):1382-1389.e9. Suzuki Y, Maazi H, Sankaranarayanan I, Lam J, Khoo B, Soroosh P, Barbers RG, James Ou JH, Jung JU, Akbari O. PMID: 26589586; PMCID: PMC4860134.
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    86. Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. PLoS One. 2014; 9(1):e87617. Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H. PMID: 24475315; PMCID: PMC3903765.
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    87. Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. PLoS One. 2013; 8(3):e59599. Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O. PMID: 23555047; PMCID: PMC3598698.
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    90. Sex-specific perinatal nicotine-induced asthma in rat offspring. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):53-62. Liu J, Naeem E, Tian J, Lombardi V, Kwong K, Akbari O, Torday JS, Rehan VK. PMID: 23002101; PMCID: PMC3547089.
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    91. Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. J Immunol. 2012 Mar 01; 188(5):2254-65. Kerzerho J, Yu ED, Barra CM, Alari-Pahissa E, Alari-Pahisa E, Girardi E, Harrak Y, Lauzurica P, Llebaria A, Zajonc DM, Akbari O, Castaño AR. PMID: 22301545; PMCID: PMC3288653.
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    93. Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan; 121(1):277-87. Li M, Krishnaveni MS, Li C, Zhou B, Xing Y, Banfalvi A, Li A, Lombardi V, Akbari O, Borok Z, Minoo P. PMID: 21135509; PMCID: PMC3007138.
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    94. TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. J Immunol. 2010 Dec 01; 185(11):6839-49. Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH. PMID: 21037090; PMCID: PMC3153437.
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    96. Dendritic cell modulation as a new interventional approach for the treatment of asthma. Drug News Perspect. 2009 Oct; 22(8):445-51. Lombardi V, Akbari O. PMID: 20016853; PMCID: PMC2845716.
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    99. Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 2009 Apr 15; 182(8):5116-22. Stock P, Lombardi V, Kohlrautz V, Akbari O. PMID: 19342692; PMCID: PMC2837931.
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    100. Natural killer T cells in the lungs of patients with asthma. J Allergy Clin Immunol. 2009 May; 123(5):1181-5. Matangkasombut P, Marigowda G, Ervine A, Idris L, Pichavant M, Kim HY, Yasumi T, Wilson SB, DeKruyff RH, Faul JL, Israel E, Akbari O, Umetsu DT. PMID: 19356791; PMCID: PMC2734957.
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    102. Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop. Eur J Immunol. 2008 Jun; 38(6):1756-66. Exley MA, Hou R, Shaulov A, Tonti E, Dellabona P, Casorati G, Akbari O, Akman HO, Greenfield EA, Gumperz JE, Boyson JE, Balk SP, Wilson SB. PMID: 18493987; PMCID: PMC2864538.
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    103. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol. 2008 Apr 15; 180(8):5448-56. Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. PMID: 18390727; PMCID: PMC2835525.
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    108. Respiratory tolerance is inhibited by the administration of corticosteroids. J Immunol. 2005 Dec 01; 175(11):7380-7. Stock P, Akbari O, DeKruyff RH, Umetsu DT. PMID: 16301645.
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    113. CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation. Eur J Immunol. 2004 Jul; 34(7):1817-27. Stock P, Kallinich T, Akbari O, Quarcoo D, Gerhold K, Wahn U, Umetsu DT, Hamelmann E. PMID: 15214030.
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    118. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol. 2002 Sep; 110(3):460-8. Oh JW, Seroogy CM, Meyer EH, Akbari O, Berry G, Fathman CG, Dekruyff RH, Umetsu DT. PMID: 12209095.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    119. Asthma: an epidemic of dysregulated immunity. Nat Immunol. 2002 Aug; 3(8):715-20. Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH. PMID: 12145657.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansCellsPHPublic Health
    120. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32. Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. PMID: 12145647.
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