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    Omid Akbari, PhD

    TitleProfessor of Molecular Microbiology & Immunology
    SchoolKeck School of Medicine of USC
    DepartmentMolecular Microbiology and Immunology
    AddressNRT 5505 1450 Biggy Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 7930
    Emailakbari@usc.edu
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Maazi H, Suzuki Y, Jung J, Akbari O. Reply. J Allergy Clin Immunol. 2016 Nov 12. PMID: 27847142.
        View in: PubMed
      2. Galle-Treger L, Suzuki Y, Patel N, Sankaranarayanan I, Aron JL, Maazi H, Chen L, Akbari O. Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity. Nat Commun. 2016 Oct 18; 7:13202. PMID: 27752043.
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      3. Rigas D, Lewis G, Aron JL, Wang B, Banie H, Sankaranarayanan I, Galle-Treger L, Maazi H, Lo R, Freeman GJ, Sharpe AH, Soroosh P, Akbari O. ILC2 Suppression by Regulatory T Cells Attenuates Airway Hyperreactivity and Requires ICOS:ICOS-Ligand Interaction. J Allergy Clin Immunol. 2016 Oct 4. PMID: 27717665.
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      4. Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJ, Aswad DW, Laird-Offringa IA. Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. J Neuroimmunol. 2016 Oct 15; 299:70-78. PMID: 27725125.
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      5. Simmerman E, Qin X, Marshall B, Perry L, Cai L, Wang T, Yu J, Akbari O, Baban B. Innate lymphoid cells: a paradigm for low SSI in cleft lip repair. J Surg Res. 2016 Oct; 205(2):312-7. PMID: 27664878.
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      6. Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P. I?B Kinase e Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Rep. 2016 Jul 12; 16(2):405-18. PMID: 27346349.
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      7. Tian Y, Kuo CF, Akbari O, Ou JH. Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016 May 17; 44(5):1204-14. PMID: 27156385.
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      8. Gyllenhammer LE, Lam J, Alderete TL, Allayee H, Akbari O, Katkhouda N, Goran MI. Lower omental t-regulatory cell count is associated with higher fasting glucose and lower ß-cell function in adults with obesity. Obesity (Silver Spring). 2016 Jun; 24(6):1274-82. PMID: 27133873.
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      9. Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, Golub ET, Sharp GB, Kovacs A. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr. 2016 Feb 1; 71(2):172-80. PMID: 26761519.
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      10. Suzuki Y, Maazi H, Sankaranarayanan I, Lam J, Khoo B, Soroosh P, Barbers RG, James Ou JH, Jung JU, Akbari O. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol. 2015 Nov 14. PMID: 26589586.
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      11. Maazi H, Akbari O. ICOS regulates ILC2s in asthma. Oncotarget. 2015 Aug 22. PMID: 26309088.
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      12. Wen X, Kim S, Xiong R, Li M, Lawrenczyk A, Huang X, Chen SY, Rao P, Besra GS, Dellabona P, Casorati G, Porcelli SA, Akbari O, Exley MA, Yuan W. A Subset of CD8aß+ Invariant NKT Cells in a Humanized Mouse Model. J Immunol. 2015 Aug 15; 195(4):1459-69. PMID: 26157173.
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      13. Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O. ICOS:ICOS-Ligand Interaction Is Required for Type 2 Innate Lymphoid Cell Function, Homeostasis, and Induction of Airway Hyperreactivity. Immunity. 2015 Mar 17; 42(3):538-51. PMID: 25769613.
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      14. Mott KR, Maazi H, Allen SJ, Zandian M, Matundan H, Ghiasi YN, Sharifi BG, Underhill D, Akbari O, Ghiasi H. Batf3 deficiency is not critical for the generation of CD8a(+) dendritic cells. Immunobiology. 2014 Oct 30. PMID: 25468565.
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      15. Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H. Inclusion of CD80 in HSV Targets the Recombinant Virus to PD-L1 on DCs and Allows Productive Infection and Robust Immune Responses. PLoS One. 2014; 9(1):e87617. PMID: 24475315.
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      16. Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O. Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. PLoS One. 2013; 8(3):e59599. PMID: 23555047.
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      17. Kerzerho J, Maazi H, Speak AO, Szely N, Lombardi V, Khoo B, Geryak S, Lam J, Soroosh P, Van Snick J, Akbari O. Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity. J Allergy Clin Immunol. 2013 Apr; 131(4):1048-57, 1057.e1-2. PMID: 23174661.
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      18. Rehan VK, Liu J, Naeem E, Tian J, Sakurai R, Kwong K, Akbari O, Torday JS. Perinatal nicotine exposure induces asthma in second generation offspring. BMC Med. 2012; 10:129. PMID: 23106849.
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      19. Liu J, Naeem E, Tian J, Lombardi V, Kwong K, Akbari O, Torday JS, Rehan VK. Sex-specific perinatal nicotine-induced asthma in rat offspring. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):53-62. PMID: 23002101.
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      20. Kerzerho J, Yu ED, Barra CM, Alari-Pahisa E, Girardi E, Harrak Y, Lauzurica P, Llebaria A, Zajonc DM, Akbari O, Castaño AR. Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. J Immunol. 2012 Mar 1; 188(5):2254-65. PMID: 22301545.
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      21. Kerzerho J, Wunsch D, Szely N, Meyer HA, Lurz L, Röse L, Wahn U, Akbari O, Stock P. Effects of Systemic versus Local Administration of Corticosteroids on Mucosal Tolerance. J Immunol. 2012 Jan 1; 188(1):470-6. PMID: 22105997.
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      22. Li M, Krishnaveni MS, Li C, Zhou B, Xing Y, Banfalvi A, Li A, Lombardi V, Akbari O, Borok Z, Minoo P. Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan 4; 121(1):277-87. PMID: 21135509.
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      23. Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH. TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. J Immunol. 2010 Dec 1; 185(11):6839-49. PMID: 21037090.
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      24. Lombardi V, Stock P, Singh AK, Kerzerho J, Yang W, Sullivan BA, Li X, Shiratsuchi T, Hnatiuk NE, Howell AR, Yu KO, Porcelli SA, Tsuji M, Kronenberg M, Wilson SB, Akbari O. A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. J Immunol. 2010 Feb 15; 184(4):2107-15. PMID: 20083656.
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      25. Lombardi V, Akbari O. Dendritic cell modulation as a new interventional approach for the treatment of asthma. Drug News Perspect. 2009 Oct; 22(8):445-51. PMID: 20016853.
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      26. Lombardi V, Singh AK, Akbari O. The role of costimulatory molecules in allergic disease and asthma. Int Arch Allergy Immunol. 2010; 151(3):179-89. PMID: 19786798.
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      27. Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, Sharpe AH, Umetsu DT, Dekruyff RH. PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. Mucosal Immunol. 2010 Jan; 3(1):81-91. PMID: 19741598.
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      28. Stock P, Lombardi V, Kohlrautz V, Akbari O. Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 2009 Apr 15; 182(8):5116-22. PMID: 19342692.
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      29. Matangkasombut P, Marigowda G, Ervine A, Idris L, Pichavant M, Kim HY, Yasumi T, Wilson SB, DeKruyff RH, Faul JL, Israel E, Akbari O, Umetsu DT. Natural killer T cells in the lungs of patients with asthma. J Allergy Clin Immunol. 2009 May; 123(5):1181-5. PMID: 19356791.
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      30. Koh YI, Kim HY, Meyer EH, Pichavant M, Akbari O, Yasumi T, Savage PB, Dekruyff RH, Umetsu DT. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice. J Immunol. 2008 Oct 1; 181(7):4560-9. PMID: 18802058.
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      31. Exley MA, Hou R, Shaulov A, Tonti E, Dellabona P, Casorati G, Akbari O, Akman HO, Greenfield EA, Gumperz JE, Boyson JE, Balk SP, Wilson SB. Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop. Eur J Immunol. 2008 Jun; 38(6):1756-66. PMID: 18493987.
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      32. Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol. 2008 Apr 15; 180(8):5448-56. PMID: 18390727.
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      33. Stock P, Akbari O. Recent advances in the role of NKT cells in allergic diseases and asthma. Curr Allergy Asthma Rep. 2008 Apr; 8(2):165-70. PMID: 18417059.
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      34. Akbari O, Faul JL, Umetsu DT. Invariant natural killer T cells in obstructive pulmonary diseases. N Engl J Med. 2007 Jul 12; 357(2):193-4; author reply 194-5. PMID: 17625134.
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      35. Akbari O, Faul JL, Hoyte EG, Berry GJ, Wahlström J, Kronenberg M, DeKruyff RH, Umetsu DT. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med. 2006 Mar 16; 354(11):1117-29. PMID: 16540612.
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      36. Meyer EH, Goya S, Akbari O, Berry GJ, Savage PB, Kronenberg M, Nakayama T, DeKruyff RH, Umetsu DT. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2782-7. PMID: 16478801.
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      37. Stock P, Akbari O, DeKruyff RH, Umetsu DT. Respiratory tolerance is inhibited by the administration of corticosteroids. J Immunol. 2005 Dec 1; 175(11):7380-7. PMID: 16301645.
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      38. Umetsu SE, Lee WL, McIntire JJ, Downey L, Sanjanwala B, Akbari O, Berry GJ, Nagumo H, Freeman GJ, Umetsu DT, DeKruyff RH. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol. 2005 May; 6(5):447-54. PMID: 15793575.
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      39. Akbari O, Umetsu DT. Role of regulatory dendritic cells in allergy and asthma. Curr Allergy Asthma Rep. 2005 Jan; 5(1):56-61. PMID: 15659264.
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      40. Akbari O, Umetsu DT. Role of regulatory dendritic cells in allergy and asthma. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):533-8. PMID: 15640695.
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      41. Stock P, Akbari O, Berry G, Freeman GJ, Dekruyff RH, Umetsu DT. Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat Immunol. 2004 Nov; 5(11):1149-56. PMID: 15448689.
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      42. Stock P, Kallinich T, Akbari O, Quarcoo D, Gerhold K, Wahn U, Umetsu DT, Hamelmann E. CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation. Eur J Immunol. 2004 Jul; 34(7):1817-27. PMID: 15214030.
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      43. Akbari O, Stock P, DeKruyff RH, Umetsu DT. Role of regulatory T cells in allergy and asthma. Curr Opin Immunol. 2003 Dec; 15(6):627-33. PMID: 14630195.
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      44. Umetsu DT, Akbari O, Dekruyff RH. Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol. 2003 Sep; 112(3):480-7; quiz 488. PMID: 13679803.
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      45. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med. 2003 May; 9(5):582-8. PMID: 12669034.
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      46. Akbari O, Stock P, DeKruyff RH, Umetsu DT. Mucosal tolerance and immunity: regulating the development of allergic disease and asthma. Int Arch Allergy Immunol. 2003 Feb; 130(2):108-18. PMID: 12673064.
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      47. Oh JW, Seroogy CM, Meyer EH, Akbari O, Berry G, Fathman CG, Dekruyff RH, Umetsu DT. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol. 2002 Sep; 110(3):460-8. PMID: 12209095.
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      48. Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH. Asthma: an epidemic of dysregulated immunity. Nat Immunol. 2002 Aug; 3(8):715-20. PMID: 12145657.
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      49. Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32. PMID: 12145647.
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