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Enhancing brain entry and therapeutic activity of chimeric antigen receptor T cells with intra-arterial NEO100 in a mouse model of CNS lymphoma. J Neurosurg. 2024 Jun 01; 140(6):1549-1557.
Wang W, He H, Zheng L, Zeng S, Cho HY, Kouhi A, Khawli LA, Chen L, Stathopoulos A, Schönthal AH, Epstein AL, Chen TC. PMID: 38157532.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Immune Priming with Spatially Fractionated Radiation Therapy. Curr Oncol Rep. 2023 12; 25(12):1483-1496.
Lukas L, Zhang H, Cheng K, Epstein A. PMID: 37979032; PMCID: PMC10728252.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Enhanced brain entry of checkpoint-inhibitory therapeutic antibodies facilitated by intraarterial NEO100 in mouse models of brain-localized malignancies. J Neurosurg. 2023 09 01; 139(3):822-830.
Wang W, He H, Zeng S, Cho HY, Minea RO, Swenson SD, Zheng L, Epstein AL, Stathopoulos A, Chen L, Schönthal AH, Chen TC. PMID: 36738464.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
The anticancer effects of Metformin in the male germ tumor SEM-1 cell line are mediated by HMGA1. Front Endocrinol (Lausanne). 2022; 13:1051988.
Salatino A, Mirabelli M, Chiefari E, Greco M, Di Vito A, Bonapace G, Brunetti FS, Crocerossa F, Epstein AL, Foti DP, Brunetti A. PMID: 36506071; PMCID: PMC9727077.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression. Biochem Biophys Res Commun. 2022 12 17; 634:100-107.
Lapierre JA, Geary LA, Jang JK, Epstein AL, Hong F, Shih JC. PMID: 36242915.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Eliciting anti-cancer immunity by genetically engineered multifunctional exosomes. Mol Ther. 2022 09 07; 30(9):3066-3077.
Cheng Q, Dai Z, Smbatyan G, Epstein AL, Lenz HJ, Zhang Y. PMID: 35746867; PMCID: PMC9481992.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Targeting macrophages for enhancing CD47 blockade-elicited lymphoma clearance and overcoming tumor-induced immunosuppression. Blood. 2022 06 02; 139(22):3290-3302.
Cao X, Wang Y, Zhang W, Zhong X, Gunes EG, Dang J, Wang J, Epstein AL, Querfeld C, Sun Z, Rosen ST, Feng M. PMID: 35134139; PMCID: PMC9164740.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Restoration of Follicular T Regulatory/Helper Cell Balance by OX40L-JAG1 Cotreatment Suppresses Lupus Nephritis in NZBWF1/j Mice. J Immunol. 2022 06 01; 208(11):2467-2481.
Kumar P, Balakrishnan S, Surendra Lele S, Setty S, Dhingra S, Epstein AL, Prabhakar BS. PMID: 35470257.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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NAP1051, a Lipoxin A4 Biomimetic Analogue, Demonstrates Antitumor Activity Against the Tumor Microenvironment. Mol Cancer Ther. 2021 12; 20(12):2384-2397.
Dong T, Dave P, Yoo E, Ebright B, Ahluwalia K, Zhou E, Asante I, Salimova M, Pei H, Lin T, Mead A, Li Z, Humayun M, Petasis NA, Epstein AL, Louie SG. PMID: 34607931.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model. Sci Rep. 2021 07 23; 11(1):15077.
Sta Maria NS, Khawli LA, Pachipulusu V, Lin SW, Zheng L, Cohrs D, Liu X, Hu P, Epstein AL, Jacobs RE. PMID: 34302002; PMCID: PMC8302724.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Brain Disposition of Antibody-Based Therapeutics: Dogma, Approaches and Perspectives. Int J Mol Sci. 2021 Jun 16; 22(12).
Kouhi A, Pachipulusu V, Kapenstein T, Hu P, Epstein AL, Khawli LA. PMID: 34208575; PMCID: PMC8235515.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
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Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. Haematologica. 2021 06 01; 106(6):1714-1724.
Oishi N, Hundal T, Phillips JL, Dasari S, Hu G, Viswanatha DS, He R, Mai M, Jacobs HK, Ahmed NH, Syrbu SI, Salama Y, Chapman JR, Vega F, Sidhu J, Bennani NN, Epstein AL, Medeiros JL, Clemens MW, Miranda RN, Feldman AL. PMID: 32414854; PMCID: PMC8168507.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
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NEO100 enables brain delivery of blood‒brain barrier impermeable therapeutics. Neuro Oncol. 2021 01 30; 23(1):63-75.
Wang W, Marín-Ramos NI, He H, Zeng S, Cho HY, Swenson SD, Zheng L, Epstein AL, Schönthal AH, Hofman FM, Chen L, Chen TC. PMID: 32877532; PMCID: PMC7850137.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Adopting an alternative structure for clinical trials in immunotherapy. Expert Rev Anticancer Ther. 2021 04; 21(4):373-375.
Roussos Torres ET, Epstein AL. PMID: 33435760.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
Nuclear Localization of PTTG1 Promotes Migration and Invasion of Seminoma Tumor through Activation of MMP-2. Cancers (Basel). 2021 Jan 08; 13(2).
Teveroni E, Di Nicuolo F, Bianchetti G, Epstein AL, Grande G, Maulucci G, De Spirito M, Pontecorvi A, Milardi D, Mancini F. PMID: 33430117; PMCID: PMC7826632.
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PubMed Mentions:
9
-
Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma. Oncoimmunology. 2021 01 04; 10(1):1838140.
Shirinbak S, Chan RY, Shahani S, Muthugounder S, Kennedy R, Hung LT, Fernandez GE, Hadjidaniel MD, Moghimi B, Sheard MA, Epstein AL, Fabbri M, Shimada H, Asgharzadeh S. PMID: 33489468; PMCID: PMC7801125.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Spontaneous Intraparenchymal Hepatic Hemorrhage as a Sequela of COVID-19. Cureus. 2020 Sep 14; 12(9):e10447.
Daid SS, Toribio AD, Lakshmanan S, Sadda A, Epstein A. PMID: 33072456; PMCID: PMC7557520.
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PubMed Mentions:
4
-
Adaptable antibody Nanoworms designed for non-Hodgkin lymphoma. Biomaterials. 2020 12; 262:120338.
Lee C, Peddi S, Anderson C, Su H, Cui H, Epstein AL, MacKay JA. PMID: 32916604; PMCID: PMC8386582.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations. Antibodies (Basel). 2020 Jun 10; 9(2).
Boune S, Hu P, Epstein AL, Khawli LA. PMID: 32532067; PMCID: PMC7345016.
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PubMed Mentions:
37
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Comparative Analysis of Cytokines of Tumor Cell Lines, Malignant and Benign Effusions Around Breast Implants. Aesthet Surg J. 2020 05 16; 40(6):630-637.
Kadin ME, Morgan J, Kouttab N, Xu H, Adams WP, Glicksman C, McGuire P, Sieber D, Epstein AL, Miranda RN, Clemens MW. PMID: 31589747.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models. Clin Cancer Res. 2020 07 15; 26(14):3694-3706.
Zheng L, Ren L, Kouhi A, Khawli LA, Hu P, Kaslow HR, Epstein AL. PMID: 32273277.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Targetability of STAT3-JAK2 fusions: implications for T-cell lymphoproliferative disorders of the gastrointestinal tract. Leukemia. 2020 05; 34(5):1467-1471.
Hu G, Phillips JL, Dasari S, Jacobs HK, Luchtel RA, Oishi N, Hundal T, Ahmed NH, Satou A, Epstein AL, Bennani NN, Nowakowski GS, Murray JA, Feldman AL. PMID: 31836854; PMCID: PMC7196010.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy. Mol Ther. 2020 02 05; 28(2):536-547.
Shi X, Cheng Q, Hou T, Han M, Smbatyan G, Lang JE, Epstein AL, Lenz HJ, Zhang Y. PMID: 31843452; PMCID: PMC7001084.
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PubMed Mentions:
86 Fields:
Translation:
HumansAnimalsCells
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Expression of the luteinizing hormone receptor (LHR) in ovarian cancer. BMC Cancer. 2019 Nov 15; 19(1):1114.
Xiong S, Mhawech-Fauceglia P, Tsao-Wei D, Roman L, Gaur RK, Epstein AL, Pinski J. PMID: 31729966; PMCID: PMC6857310.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling. J Immunol. 2019 12 15; 203(12):3225-3236.
Kumar P, Lele SS, Ragothaman VK, Raghunathan D, Epstein AL, Chiba S, Prabhakar BS. PMID: 31704879; PMCID: PMC6904432.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Generation of a Monoclonal Antibody to Detect Elastin-like Polypeptides. Biomacromolecules. 2019 08 12; 20(8):2942-2952.
Kouhi A, Yao Z, Zheng L, Li Z, Hu P, Epstein AL, MacKay JA. PMID: 31276401; PMCID: PMC7219198.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsPHPublic Health
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Antibodies to Brewer's Yeast in Rheumatoid Arthritis. Cureus. 2019 May 17; 11(5):e4691.
Lichtenstein JR, Epstein AL. PMID: 31333917; PMCID: PMC6636702.
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PubMed Mentions:
-
Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. Nat Commun. 2019 02 12; 10(1):713.
Galle-Treger L, Sankaranarayanan I, Hurrell BP, Howard E, Lo R, Maazi H, Lewis G, Banie H, Epstein AL, Hu P, Rehan VK, Gilliland FD, Allayee H, Soroosh P, Sharpe AH, Akbari O. PMID: 30755607; PMCID: PMC6372786.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun. 2018 05 22; 9(1):2024.
Ng SY, Yoshida N, Christie AL, Ghandi M, Dharia NV, Dempster J, Murakami M, Shigemori K, Morrow SN, Van Scoyk A, Cordero NA, Stevenson KE, Puligandla M, Haas B, Lo C, Meyers R, Gao G, Cherniack A, Louissaint A, Nardi V, Thorner AR, Long H, Qiu X, Morgan EA, Dorfman DM, Fiore D, Jang J, Epstein AL, Dogan A, Zhang Y, Horwitz SM, Jacobsen ED, Santiago S, Ren JG, Guerlavais V, Annis DA, Aivado M, Saleh MN, Mehta A, Tsherniak A, Root D, Vazquez F, Hahn WC, Inghirami G, Aster JC, Weinstock DM, Koch R. PMID: 29789628; PMCID: PMC5964252.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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IL-13 is produced by tumor cells in breast implant-associated anaplastic large cell lymphoma: implications for pathogenesis. Hum Pathol. 2018 08; 78:54-62.
Kadin ME, Morgan J, Xu H, Epstein AL, Sieber D, Hubbard BA, Adams WP, Bacchi CE, Goes JCS, Clemens MW, Medeiros LJ, Miranda RN. PMID: 29689246.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation. Cell Mol Immunol. 2019 02; 16(2):138-153.
Kumar P, Marinelarena A, Raghunathan D, Ragothaman VK, Saini S, Bhattacharya P, Fan J, Epstein AL, Maker AV, Prabhakar BS. PMID: 29578532; PMCID: PMC6355936.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Lym-1 Chimeric Antigen Receptor T Cells Exhibit Potent Anti-Tumor Effects against B-Cell Lymphoma. Int J Mol Sci. 2017 Dec 20; 18(12).
Zheng L, Hu P, Wolfe B, Gonsalves C, Ren L, Khawli LA, Kaslow HR, Epstein AL. PMID: 29261129; PMCID: PMC5751371.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells. Sci Rep. 2017 07 26; 7(1):6594.
Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Bhattacharya P, Sun Z, Epstein AL, Maker AV, Prabhakar BS. PMID: 28747670; PMCID: PMC5529425.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):3975-3980.
Chen J, Zhang Y, Petrus MN, Xiao W, Nicolae A, Raffeld M, Pittaluga S, Bamford RN, Nakagawa M, Ouyang ST, Epstein AL, Kadin ME, Del Mistro A, Woessner R, Jaffe ES, Waldmann TA. PMID: 28356514; PMCID: PMC5393253.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling. Sci Rep. 2017 01 03; 7:39751.
Kumar P, Alharshawi K, Bhattacharya P, Marinelarena A, Haddad C, Sun Z, Chiba S, Epstein AL, Prabhakar BS. PMID: 28045060; PMCID: PMC5206631.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins. J Immunol Res. 2016; 2016:2342187.
Smith A, Manoli H, Jaw S, Frutoz K, Epstein AL, Khawli LA, Theil FP. PMID: 27579329; PMCID: PMC4992793.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice. Autoimmunity. 2016 08; 49(5):298-311.
Haddad CS, Bhattacharya P, Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Elshabrawy HA, Epstein AL, Prabhakar BS. PMID: 27245356; PMCID: PMC5042830.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Biomarkers Provide Clues to Early Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large Cell Lymphoma. Aesthet Surg J. 2016 Jul; 36(7):773-81.
Kadin ME, Deva A, Xu H, Morgan J, Khare P, MacLeod RA, Van Natta BW, Adams WP, Brody GS, Epstein AL. PMID: 26979456.
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PubMed Mentions:
40 Fields:
Translation:
Humans
-
Systemic delivery of chTNT-3/CpG immunoconjugates for immunotherapy in murine solid tumor models. Cancer Immunol Immunother. 2016 May; 65(5):511-23.
Jang JK, Khawli LA, Canter DC, Hu P, Zhu TH, Wu BW, Angell TE, Li Z, Epstein AL. PMID: 26960932; PMCID: PMC4841721.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant. J Immunother Cancer. 2016; 4:11.
Andersen BM, Xia J, Epstein AL, Ohlfest JR, Chen W, Blazar BR, Pennell CA, Olin MR. PMID: 26885373; PMCID: PMC4755027.
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PubMed Mentions:
14 Fields:
-
Circulating Myeloid-Derived Suppressor Cells Predict Differentiated Thyroid Cancer Diagnosis and Extent. Thyroid. 2016 Mar; 26(3):381-9.
Angell TE, Lechner MG, Smith AM, Martin SE, Groshen SG, Maceri DR, Singer PA, Epstein AL. PMID: 26756227; PMCID: PMC4790214.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Phase 1 Dose-Escalation Study with LEC/chTNT-3 and Toceranib Phosphate (Palladia®) in Dogs with Spontaneous Malignancies. J Cancer Sci Ther. 2015; 7(6):167-174.
Jang JK, Chretin J, Bruyette D, Hu P, Epstein AL. PMID: 26635918; PMCID: PMC4666026.
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PubMed Mentions:
1
-
Anaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases. Plast Reconstr Surg. 2015 Mar; 135(3):695-705.
Brody GS, Deapen D, Taylor CR, Pinter-Brown L, House-Lightner SR, Andersen JS, Carlson G, Lechner MG, Epstein AL. PMID: 25490535.
View in:
PubMed Mentions:
95 Fields:
Translation:
Humans
-
MHC class I loss is a frequent mechanism of immune escape in papillary thyroid cancer that is reversed by interferon and selumetinib treatment in vitro. Clin Cancer Res. 2014 Dec 01; 20(23):6034-44.
Angell TE, Lechner MG, Jang JK, LoPresti JS, Epstein AL. PMID: 25294906; PMCID: PMC4252612.
View in:
PubMed Mentions:
71 Fields:
Translation:
HumansCells
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Treatment of experimental pancreatic cancer with 213-Bismuth-labeled chimeric antibody to single-strand DNA. Expert Rev Anticancer Ther. 2014 Oct; 14(10):1243-9.
Bryan RA, Jiang Z, Jandl T, Strauss J, Koba W, Onyedika C, Morgenstern A, Bruchertseifer F, Epstein AL, Dadachova E. PMID: 25156106.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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BRAF V600E in papillary thyroid carcinoma is associated with increased programmed death ligand 1 expression and suppressive immune cell infiltration. Thyroid. 2014 Sep; 24(9):1385-93.
Angell TE, Lechner MG, Jang JK, Correa AJ, LoPresti JS, Epstein AL. PMID: 24955518; PMCID: PMC4148060.
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PubMed Mentions:
68 Fields:
Translation:
Humans
-
A hybrid protein-polymer nanoworm potentiates apoptosis better than a monoclonal antibody. ACS Nano. 2014 Mar 25; 8(3):2064-76.
Aluri SR, Shi P, Gustafson JA, Wang W, Lin YA, Cui H, Liu S, Conti PS, Li Z, Hu P, Epstein AL, MacKay JA. PMID: 24484356; PMCID: PMC4004287.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Boron neutron capture therapy as new treatment for clear cell sarcoma: trial on different animal model. Appl Radiat Isot. 2014 Jun; 88:59-63.
Andoh T, Fujimoto T, Sudo T, Suzuki M, Sakurai Y, Sakuma T, Moritake H, Sugimoto T, Takeuchi T, Sonobe H, Epstein AL, Fukumori Y, Ono K, Ichikawa H. PMID: 24389062.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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CD8+ T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma. J Immunol. 2014 Jan 01; 192(1):224-33.
Murphy KA, Erickson JR, Johnson CS, Seiler CE, Bedi J, Hu P, Pluhar GE, Epstein AL, Ohlfest JR. PMID: 24293627; PMCID: PMC4068509.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Immunogenicity of murine solid tumor models as a defining feature of in vivo behavior and response to immunotherapy. J Immunother. 2013 Nov-Dec; 36(9):477-89.
Lechner MG, Karimi SS, Barry-Holson K, Angell TE, Murphy KA, Church CH, Ohlfest JR, Hu P, Epstein AL. PMID: 24145359; PMCID: PMC3910494.
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PubMed Mentions:
187 Fields:
Translation:
HumansAnimalsCells
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Cytoreductive chemotherapy improves the biodistribution of antibodies directed against tumor necrosis in murine solid tumor models. Mol Cancer Ther. 2013 Dec; 12(12):2827-36.
Jang JK, Khawli LA, Park R, Wu BW, Li Z, Canter D, Conti PS, Epstein AL. PMID: 24130055; PMCID: PMC3929394.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Modulation of Treg cells/T effector function by GITR signaling is context-dependent. Eur J Immunol. 2013 Sep; 43(9):2421-9.
Ephrem A, Epstein AL, Stephens GL, Thornton AM, Glass D, Shevach EM. PMID: 23722868; PMCID: PMC11022273.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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Immune cell infiltration patterns and survival in head and neck squamous cell carcinoma. Head Neck Oncol. 2013 Feb 27; 5(3):24.
Russell S, Angell T, Lechner M, Liebertz D, Correa A, Sinha U, Kokot N, Epstein A. PMID: 24723971; PMCID: PMC3979926.
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PubMed Mentions:
65 Fields:
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Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. Urology. 2013 Feb; 81(2):464.e1-9.
Russell SM, Lechner MG, Mokashi A, Megiel C, Jang JK, Taylor CR, Looijenga LH, French CA, Epstein AL. PMID: 23374840; PMCID: PMC4179199.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Generation of tumor-targeted antibody-CpG conjugates. J Immunol Methods. 2013 Mar 29; 389(1-2):45-51.
Li Z, Jang JK, Lechner MG, Hu P, Khawli L, Scannell CA, Epstein AL. PMID: 23279945.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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A rare case of noninsulinoma pancreatogenous hypoglycemia syndrome. Case Rep Gastrointest Med. 2012; 2012:164305.
Nadelson J, Epstein A. PMID: 23213581; PMCID: PMC3508526.
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PubMed Mentions:
3
-
Survival signals and targets for therapy in breast implant-associated ALK--anaplastic large cell lymphoma. Clin Cancer Res. 2012 Sep 01; 18(17):4549-59.
Lechner MG, Megiel C, Church CH, Angell TE, Russell SM, Sevell RB, Jang JK, Brody GS, Epstein AL. PMID: 22791880.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansCells
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An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas. Clin Cancer Res. 2012 Sep 01; 18(17):4657-68.
Murphy KA, Lechner MG, Popescu FE, Bedi J, Decker SA, Hu P, Erickson JR, O'Sullivan MG, Swier L, Salazar AM, Olin MR, Epstein AL, Ohlfest JR. PMID: 22781551; PMCID: PMC3432688.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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The perichromatin region of the plant cell nucleus is the area with the strongest co-localisation of snRNA and SR proteins. Planta. 2012 Aug; 236(2):715-26.
Niedojadlo J, Mikulski Z, Delenko K, Szmidt-Jaworska A, Smolinski DJ, Epstein AL. PMID: 22526497; PMCID: PMC3404291.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Unique approach for B lymphoma therapy. Blood. 2012 Apr 19; 119(16):3647-8.
Epstein AL. PMID: 22517869.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators. J Clin Cell Immunol. 2012; Suppl 5:004.
Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman FM, Epstein AL, Farghadani H, Kruse CA, Jadus MR, Chen TC, Schijns VE. PMID: 24955288; PMCID: PMC4062195.
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PubMed Mentions:
2
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Chemokines, costimulatory molecules and fusion proteins for the immunotherapy of solid tumors. Immunotherapy. 2011 Nov; 3(11):1317-40.
Lechner MG, Russell SM, Bass RS, Epstein AL. PMID: 22053884; PMCID: PMC3226699.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
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USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics. Oral Oncol. 2011 Sep; 47(9):810-7.
Russell SM, Lechner MG, Gong L, Megiel C, Liebertz DJ, Masood R, Correa AJ, Han J, Puri RK, Sinha UK, Epstein AL. PMID: 21719345; PMCID: PMC3164740.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines. J Transl Med. 2011 Jun 09; 9:90.
Lechner MG, Megiel C, Russell SM, Bingham B, Arger N, Woo T, Epstein AL. PMID: 21658270; PMCID: PMC3128058.
View in:
PubMed Mentions:
105 Fields:
Translation:
HumansCells
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Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies. Appl Radiat Isot. 2011 Dec; 69(12):1713-6.
Fujimoto T, Andoh T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Sonobe H, Epstein AL, Akisue T, Kirihata M, Kurosaka M, Fukumori Y, Ichikawa H. PMID: 21354804.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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A new mechanism for blocking myeloid-derived suppressor cells by CpG. Clin Cancer Res. 2011 Apr 01; 17(7):1645-8.
Lechner MG, Epstein AL. PMID: 21288925; PMCID: PMC4237605.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Rapidly fatal pulmonary fibrosis in a patient with psoriatic arthritis treated with adalimumab. J Rheumatol. 2011 Feb; 38(2):398-9.
Cohen JV, Capell BC, Kinniry PA, Epstein AL. PMID: 21285183.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Breast implant-associated, ALK-negative, T-cell, anaplastic, large-cell lymphoma: establishment and characterization of a model cell line (TLBR-1) for this newly emerging clinical entity. Cancer. 2011 Apr 01; 117(7):1478-89.
Lechner MG, Lade S, Liebertz DJ, Prince HM, Brody GS, Webster HR, Epstein AL. PMID: 21425149; PMCID: PMC4175713.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment. Cancer Res. 2010 Nov 15; 70(22):9041-52.
Pardee AD, McCurry D, Alber S, Hu P, Epstein AL, Storkus WJ. PMID: 21045144; PMCID: PMC3058673.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol. 2010 Aug 15; 185(4):2273-84.
Lechner MG, Liebertz DJ, Epstein AL. PMID: 20644162; PMCID: PMC2923483.
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PubMed Mentions:
308 Fields:
Translation:
HumansCells
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Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1. Head Neck Oncol. 2010 Feb 22; 2:5.
Liebertz DJ, Lechner MG, Masood R, Sinha UK, Han J, Puri RK, Correa AJ, Epstein AL. PMID: 20175927; PMCID: PMC2841166.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity. J Immunol. 2009 May 01; 182(9):5430-8.
Phares TW, Ramakrishna C, Parra GI, Epstein A, Chen L, Atkinson R, Stohlman SA, Bergmann CC. PMID: 19380790; PMCID: PMC2909606.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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Influence of an educational seminar on use of disease activity measurements by rheumatologists in treatment of rheumatoid arthritis. J Rheumatol. 2009 Mar; 36(3):532-8.
Hamburger MI, Hamburger FH, Bergman JM, Epstein A, Brown A. PMID: 19208595.
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PubMed Mentions: Fields:
Translation:
Humans
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Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models. J Immunother. 2008 Apr; 31(3):235-45.
Sadun RE, Hsu WE, Zhang N, Nien YC, Bergfeld SA, Sabzevari H, Lutsiak ME, Khawli L, Hu P, Epstein AL. PMID: 18317364.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer. Clin Cancer Res. 2008 Jan 15; 14(2):579-88.
Hu P, Arias RS, Sadun RE, Nien YC, Zhang N, Sabzevari H, Lutsiak ME, Khawli LA, Epstein AL. PMID: 18223234.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Immunogenicity of Iodine 131 chimeric tumor necrosis therapy monoclonal antibody in advanced lung cancer patients. Cancer Immunol Immunother. 2008 May; 57(5):677-84.
Wang H, Cao C, Li B, Chen S, Yin J, Shi J, Ye D, Tao Q, Hu P, Epstein A, Ju D. PMID: 17934732; PMCID: PMC11029874.
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PubMed Mentions:
7 Fields:
Translation:
HumansCTClinical Trials
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Immune signatures of murine and human cancers reveal unique mechanisms of tumor escape and new targets for cancer immunotherapy. Clin Cancer Res. 2007 Jul 01; 13(13):4016-25.
Sadun RE, Sachsman SM, Chen X, Christenson KW, Morris WZ, Hu P, Epstein AL. PMID: 17606736.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Lym-1-induced apoptosis of non-Hodgkin's lymphomas produces regression of transplanted tumors. Cancer Biother Radiopharm. 2007 Jun; 22(3):342-56.
Zhang N, Khawli LA, Hu P, Epstein AL. PMID: 17651040.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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RA8, a human anti-CD25 antibody against human Treg cells. Hybridoma (Larchmt). 2007 Jun; 26(3):119-30.
Arias RS, Flanagan ML, Miller KD, Nien YC, Hu P, Gray D, Khawli LA, Epstein AL. PMID: 17600493.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Combination immunotherapy with anti-CD20 and anti-HLA-DR monoclonal antibodies induces synergistic anti-lymphoma effects in human lymphoma cell lines. Leuk Lymphoma. 2007 May; 48(5):944-56.
Tobin E, Denardo G, Zhang N, Epstein AL, Liu C, Denardo S. PMID: 17487739.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors. Clin Cancer Res. 2007 May 01; 13(9):2758-67.
Zhang N, Sadun RE, Arias RS, Flanagan ML, Sachsman SM, Nien YC, Khawli LA, Hu P, Epstein AL. PMID: 17460060.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Soluble Fc fusion proteins for biomedical research. Methods Mol Biol. 2007; 378:33-52.
Flanagan ML, Arias RS, Hu P, Khawli LA, Epstein AL. PMID: 18605076.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCellsPHPublic Health
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B7.1/NHS76: a new costimulator fusion protein for the immunotherapy of solid tumors. J Immunother. 2006 Jul-Aug; 29(4):425-35.
Liu A, Hu P, Khawli LA, Epstein AL. PMID: 16799338.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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H60/TNT-3 fusion protein activates NK cells in vitro and improves immunotherapeutic outcome in murine syngeneic tumor models. J Immunother. 2006 May-Jun; 29(3):274-83.
Flanagan ML, Khawli LA, Hu P, Epstein AL. PMID: 16699370.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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131I-chTNT radioimmunotherapy of 43 patients with advanced lung cancer. Cancer Biother Radiopharm. 2006 Feb; 21(1):5-14.
Yu L, Ju DW, Chen W, Li T, Xu Z, Jiang C, Chen S, Tao Q, Ye D, Hu P, Khawli LA, Taylor CR, Epstein AL. PMID: 16480326.
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PubMed Mentions:
12 Fields:
Translation:
HumansCTClinical Trials
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Combination B7-Fc fusion protein treatment and Treg cell depletion therapy. Clin Cancer Res. 2005 Dec 01; 11(23):8492-502.
Liu A, Hu P, Khawli LA, Epstein AL. PMID: 16322313.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Generation of rituximab polymer may cause hyper-cross-linking-induced apoptosis in non-Hodgkin's lymphomas. Clin Cancer Res. 2005 Aug 15; 11(16):5971-80.
Zhang N, Khawli LA, Hu P, Epstein AL. PMID: 16115941.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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NHS76/PEP2, a fully human vasopermeability-enhancing agent to increase the uptake and efficacy of cancer chemotherapy. Clin Cancer Res. 2005 Apr 15; 11(8):3084-93.
Khawli LA, Hu P, Epstein AL. PMID: 15837764.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer. J Clin Oncol. 2005 Mar 01; 23(7):1538-47.
Chen S, Yu L, Jiang C, Zhao Y, Sun D, Li S, Liao G, Chen Y, Fu Q, Tao Q, Ye D, Hu P, Khawli LA, Taylor CR, Epstein AL, Ju DW. PMID: 15735129.
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PubMed Mentions:
33 Fields:
Translation:
Humans
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chTNT-3/hu IL-12 fusion protein for the immunotherapy of experimental solid tumors. Hybrid Hybridomics. 2004 Feb; 23(1):1-10.
Li J, Hu P, Khawli LA, Yun A, Epstein AL. PMID: 15000842.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Tumor targeting properties of indium-111 labeled genetically engineered Fab' and F(ab')2 constructs of chimeric tumor necrosis treatment (chTNT)-3 antibody. Cancer Biother Radiopharm. 2003 Dec; 18(6):931-40.
Khawli LA, Alauddin MM, Hu P, Epstein AL. PMID: 14969605.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Complete regression of experimental solid tumors by combination LEC/chTNT-3 immunotherapy and CD25(+) T-cell depletion. Cancer Res. 2003 Dec 01; 63(23):8384-92.
Li J, Hu P, Khawli LA, Epstein AL. PMID: 14679000.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Monoclonal LYM-1 antibody-dependent cytolysis by human neutrophils exposed to GM-CSF: auto-regulation of target cell attack by cathepsin G. J Leukoc Biol. 2004 Jan; 75(1):99-105.
Ottonello L, Epstein AL, Mancini M, Dapino P, Dallegri F. PMID: 14525961.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Comparison of three different targeted tissue factor fusion proteins for inducing tumor vessel thrombosis. Cancer Res. 2003 Aug 15; 63(16):5046-53.
Hu P, Yan J, Sharifi J, Bai T, Khawli LA, Epstein AL. PMID: 12941833.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Chimeric TNT-3 antibody/murine interferon-gamma fusion protein for the immunotherapy of solid malignancies. Hybrid Hybridomics. 2003 Aug; 22(4):197-207.
Mizokami MM, Hu P, Khawli LA, Li J, Epstein AL. PMID: 14511565.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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LEC/chTNT-3 fusion protein for the immunotherapy of experimental solid tumors. J Immunother. 2003 Jul-Aug; 26(4):320-31.
Li J, Hu P, Khawli LA, Epstein AL. PMID: 12843794.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Chimeric TNT-3/human beta-glucuronidase fusion proteins for antibody-directed enzyme prodrug therapy (ADEPT). Cancer Biother Radiopharm. 2003 Jun; 18(3):339-53.
Biela BH, Khawli LA, Hu P, Epstein AL. PMID: 12954121.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Identification of a protein fragment of interleukin 2 responsible for vasopermeability. J Natl Cancer Inst. 2003 May 21; 95(10):741-9.
Epstein AL, Mizokami MM, Li J, Hu P, Khawli LA. PMID: 12759392.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Generation of low-toxicity interleukin-2 fusion proteins devoid of vasopermeability activity. Blood. 2003 Jun 15; 101(12):4853-61.
Hu P, Mizokami M, Ruoff G, Khawli LA, Epstein AL. PMID: 12609842.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Comparison of recombinant derivatives of chimeric TNT-3 antibody for the radioimaging of solid tumors. Hybrid Hybridomics. 2003 Feb; 22(1):1-9.
Khawli LA, Biela B, Hu P, Epstein AL. PMID: 12713684.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Generation of human interferon gamma and tumor Necrosis factor alpha chimeric TNT-3 fusion proteins. Hybrid Hybridomics. 2002 Dec; 21(6):421-32.
Sharifi J, Khawli LA, Hu P, Li J, Epstein AL. PMID: 12573106.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Pharmacokinetic characteristics and biodistribution of radioiodinated chimeric TNT-1, -2, and -3 monoclonal antibodies after chemical modification with biotin. Cancer Biother Radiopharm. 2002 Aug; 17(4):359-70.
Khawli LA, Mizokami MM, Sharifi J, Hu P, Epstein AL. PMID: 12396700.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene. Cancer Genet Cytogenet. 2002 May; 135(1):48-56.
Moritake H, Sugimoto T, Asada Y, Yoshida MA, Maehara Y, Epstein AL, Kuroda H. PMID: 12072203.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Stable, genetically engineered F(ab')(2) fragments of chimeric TNT-3 expressed in mammalian cells. Hybrid Hybridomics. 2002 Feb; 21(1):11-8.
Khawli LA, Biela BH, Hu P, Epstein AL. PMID: 11991812.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells