Russell E. Jacobs, PhD

TitleProfessor of Research Physiology & Neuroscience
InstitutionUniversity of Southern California
DepartmentZilkha Neurogenetic Institute
AddressZNI 117, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 865 1668
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    Collapse Research 
    Collapse Research Activities and Funding
    In Vivo Detection of Neuronal Activity
    NIH/NIDA R01DA018184Sep 30, 2006 - May 31, 2012
    Role: Principal Investigator
    Multimodal microPET and microMRI Imaging Instrumentation
    NIH/NIBIB R01EB000993Apr 1, 2003 - Jul 31, 2014
    Role: Principal Investigator
    In Vivo Imaging of Neuronal Activity - After the Fact
    NIH/NIDA R21DA014930Sep 30, 2001 - Aug 31, 2003
    Role: Principal Investigator
    NIH/NCRR R01RR013625Sep 30, 1998 - Aug 31, 2003
    Role: Principal Investigator
    NIH/NIBIB P20EB000232Sep 30, 1993 - Aug 31, 2004
    Role: Principal Investigator
    NIH/NIDA P20DA008944Sep 30, 1993 - Aug 31, 2003
    Role: Principal Investigator
    NIH/NICHD R01HD025390Dec 1, 1989 - Jul 31, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs R, Zlokovic BV. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 Mar; 24(3):326-337. PMID: 29400711.
      View in: PubMed
    2. Thylur DS, Jacobs R, Go JL, Toga AW, Niparko JK. Ultra-High-Field Magnetic Resonance Imaging of the Human Inner Ear at 11.7?Tesla. Otol Neurotol. 2017 01; 38(1):133-138. PMID: 27755367.
      View in: PubMed
    3. Santos R, Kawauchi S, Jacobs R, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL. Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep; 14(9):e2000197. PMID: 27606604; PMCID: PMC5016002.
    4. Daianu M, Jacobs R, Weitz TM, Town TC, Thompson PM. Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats. PLoS One. 2015; 10(12):e0145205. PMID: 26683657; PMCID: PMC4687716.
    5. Sta Maria NS, Barnes SR, Weist MR, Colcher D, Raubitschek AA, Jacobs R. Low Dose Focused Ultrasound Induces Enhanced Tumor Accumulation of Natural Killer Cells. PLoS One. 2015; 10(11):e0142767. PMID: 26556731; PMCID: PMC4640510.
    6. Delora A, Gonzales A, Medina CS, Mitchell A, Mohed AF, Jacobs R, Bearer EL. A simple rapid process for semi-automated brain extraction from magnetic resonance images of the whole mouse head. J Neurosci Methods. 2016 Jan 15; 257:185-93. PMID: 26455644; PMCID: PMC4910826.
    7. Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs R. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med. 2016 May; 75(5):1967-77. PMID: 26077645; PMCID: PMC4726482 [Available on 05/01/17].
    8. Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs R. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med Imaging. 2015 Jun 16; 15:19. PMID: 26076957.
      View in: PubMed
    9. Daianu M, Jahanshad N, Villalon-Reina JE, Prasad G, Jacobs R, Barnes S, Zlokovic BV, Montagne A, Thompson PM. 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. PMID: 25859293.
      View in: PubMed
    10. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs R, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. PMID: 25611508; PMCID: PMC4350773.
    11. Sta Maria NS, Barnes SR, Jacobs R. In vivo monitoring of natural killer cell trafficking during tumor immunotherapy. Magn Reson Insights. 2014; 7:15-21. PMID: 25114550; PMCID: PMC4122546.
    12. Malkova NV, Gallagher JJ, Yu CZ, Jacobs R, Patterson PH. Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):E2492-500. PMID: 24889602; PMCID: PMC4066472.
    13. Tu C, Ng TS, Jacobs R, Louie AY. Multimodality PET/MRI agents targeted to activated macrophages. J Biol Inorg Chem. 2014 Feb; 19(2):247-58. PMID: 24166283; PMCID: PMC3946888.
    14. Ng TS, Wert D, Sohi H, Procissi D, Colcher D, Raubitschek AA, Jacobs R. Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101. Clin Cancer Res. 2013 May 01; 19(9):2518-27. PMID: 23532891; PMCID: PMC3644008.
    15. Gallagher JJ, Zhang X, Hall FS, Uhl GR, Bearer EL, Jacobs R. Altered reward circuitry in the norepinephrine transporter knockout mouse. PLoS One. 2013; 8(3):e57597. PMID: 23469209; PMCID: PMC3587643.
    16. Ng TS, Bading JR, Park R, Sohi H, Procissi D, Colcher D, Conti PS, Cherry SR, Raubitschek AA, Jacobs R. Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner. J Nucl Med. 2012 Jul; 53(7):1102-9. PMID: 22661534; PMCID: PMC3552656.
    17. MacKenzie-Graham AJ, Rinek GA, Avedisian A, Morales LB, Umeda E, Boulat B, Jacobs R, Toga AW, Voskuhl RR. Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis. J Neurosci Res. 2012 Jul; 90(7):1310-23. PMID: 22411609; PMCID: PMC3350614.
    18. Gallagher JJ, Zhang X, Ziomek GJ, Jacobs R, Bearer EL. Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI. Neuroimage. 2012 Apr 15; 60(3):1856-66. PMID: 22500926; PMCID: PMC3328142.
    19. Perles-Barbacaru TA, Procissi D, Demyanenko AV, Jacobs R. Quantitative pharmacologic MRI in mice. NMR Biomed. 2012 Apr; 25(4):498-505. PMID: 21793079; PMCID: PMC3292675.
    20. Tu C, Ng TS, Sohi HK, Palko HA, House A, Jacobs R, Louie AY. Receptor-targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques. Biomaterials. 2011 Oct; 32(29):7209-16. PMID: 21742374; PMCID: PMC3148412.
    21. Ruffins SW, Jacobs R. MRI in developmental biology and the construction of developmental atlases. Cold Spring Harb Protoc. 2011 Mar 01; 2011(3):top100. PMID: 21363957.
      View in: PubMed
    22. Perles-Barbacaru TA, Procissi D, Demyanenko AV, Hall FS, Uhl GR, Jacobs R. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. Neuroimage. 2011 Mar 15; 55(2):622-8. PMID: 21185387; PMCID: PMC3035982.
    23. Zhang X, Bearer EL, Boulat B, Hall FS, Uhl GR, Jacobs R. Altered neurocircuitry in the dopamine transporter knockout mouse brain. PLoS One. 2010 Jul 09; 5(7):e11506. PMID: 20634895; PMCID: PMC2901340.
    24. Zhang X, Bearer EL, Perles-Barbacaru AT, Jacobs R. Increased anatomical detail by in vitro MR microscopy with a modified Golgi impregnation method. Magn Reson Med. 2010 May; 63(5):1391-7. PMID: 20432310; PMCID: PMC3387550.
    25. Ng TS, Procissi D, Wu Y, Jacobs R. A robust coregistration method for in vivo studies using a first generation simultaneous PET/MR scanner. Med Phys. 2010 May; 37(5):1995-2003. PMID: 20527533; PMCID: PMC2866256.
    26. MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs R, Johnson GA, Toga AW, Voskuhl RR. Purkinje cell loss in experimental autoimmune encephalomyelitis. Neuroimage. 2009 Dec; 48(4):637-51. PMID: 19589388; PMCID: PMC2754586.
    27. Bearer EL, Zhang X, Janvelyan D, Boulat B, Jacobs R. Reward circuitry is perturbed in the absence of the serotonin transporter. Neuroimage. 2009 Jul 15; 46(4):1091-104. PMID: 19306930; PMCID: PMC2693299.
    28. Lazovic J, Jensen MC, Ferkassian E, Aguilar B, Raubitschek A, Jacobs R. Imaging immune response in vivo: cytolytic action of genetically altered T cells directed to glioblastoma multiforme. Clin Cancer Res. 2008 Jun 15; 14(12):3832-9. PMID: 18559603; PMCID: PMC2737486.
    29. Catana C, Procissi D, Wu Y, Judenhofer MS, Qi J, Pichler BJ, Jacobs R, Cherry SR. Simultaneous in vivo positron emission tomography and magnetic resonance imaging. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3705-10. PMID: 18319342; PMCID: PMC2268792.
    30. Zinnanti WJ, Lazovic J, Housman C, LaNoue K, O'Callaghan JP, Simpson I, Woontner M, Goodman SI, Connor JR, Jacobs R, Cheng KC. Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I. J Clin Invest. 2007 Nov; 117(11):3258-70. PMID: 17932566; PMCID: PMC2000809.
    31. Bearer EL, Zhang X, Jacobs R. Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome. Neuroimage. 2007 Aug 01; 37(1):230-42. PMID: 17566763; PMCID: PMC2074885.
    32. Bearer EL, Falzone TL, Zhang X, Biris O, Rasin A, Jacobs R. Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI). Neuroimage. 2007; 37 Suppl 1:S37-46. PMID: 17600729; PMCID: PMC2096707.
    33. Ruffins SW, Martin M, Keough L, Truong S, Fraser SE, Jacobs R, Lansford R. Digital three-dimensional atlas of quail development using high-resolution MRI. ScientificWorldJournal. 2007 May 11; 7:592-604. PMID: 17525824.
      View in: PubMed
    34. Papan C, Boulat B, Velan SS, Fraser SE, Jacobs R. Formation of the dorsal marginal zone in Xenopus laevis analyzed by time-lapse microscopic magnetic resonance imaging. Dev Biol. 2007 May 01; 305(1):161-71. PMID: 17368611.
      View in: PubMed
    35. Papan C, Boulat B, Velan SS, Fraser SE, Jacobs R. Two-dimensional and three-dimensional time-lapse microscopic magnetic resonance imaging of Xenopus gastrulation movements using intrinsic tissue-specific contrast. Dev Dyn. 2007 Feb; 236(2):494-501. PMID: 17191224.
      View in: PubMed
    36. Mackenzie-Graham AJ, Lee EF, Dinov ID, Yuan H, Jacobs R, Toga AW. Multimodal, multidimensional models of mouse brain. Epilepsia. 2007; 48 Suppl 4:75-81. PMID: 17767578; PMCID: PMC3192853.
    37. Obenaus A, Jacobs R. Magnetic resonance imaging of functional anatomy: use for small animal epilepsy models. Epilepsia. 2007; 48 Suppl 4:11-7. PMID: 17767571.
      View in: PubMed
    38. Martin M, Hiltner TD, Wood JC, Fraser SE, Jacobs R, Readhead C. Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice. J Neurosci Res. 2006 Dec; 84(8):1716-26. PMID: 17044038.
      View in: PubMed
    39. Papan C, Boulat B, Velan SS, Fraser SE, Jacobs R. Time-lapse tracing of mitotic cell divisions in the early Xenopus embryo using microscopic MRI. Dev Dyn. 2006 Nov; 235(11):3059-62. PMID: 16958098.
      View in: PubMed
    40. Martin M, Reyes SD, Hiltner TD, Givogri MI, Tyszka JM, Fisher R, Campagnoni AT, Fraser SE, Jacobs R, Readhead C. T(2)-weighted microMRI and evoked potential of the visual system measurements during the development of hypomyelinated transgenic mice. Neurochem Res. 2007 Feb; 32(2):159-65. PMID: 16927171.
      View in: PubMed
    41. MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs R, Voskuhl RR, Toga AW. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. Neuroimage. 2006 Sep; 32(3):1016-23. PMID: 16806982.
      View in: PubMed
    42. Lee EF, Jacobs R, Dinov I, Leow A, Toga AW. Standard atlas space for C57BL/6J neonatal mouse brain. Anat Embryol (Berl). 2005 Nov; 210(4):245-63. PMID: 16228227.
      View in: PubMed
    43. Tyszka JM, Readhead C, Bearer EL, Pautler RG, Jacobs R. Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant. Neuroimage. 2006 Feb 15; 29(4):1058-65. PMID: 16213163; PMCID: PMC3376084.
    44. Jacobs EC, Pribyl TM, Feng JM, Kampf K, Spreur V, Campagnoni C, Colwell CS, Reyes SD, Martin M, Handley V, Hiltner TD, Readhead C, Jacobs R, Messing A, Fisher RS, Campagnoni AT. Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene. J Neurosci. 2005 Jul 27; 25(30):7004-13. PMID: 16049176.
      View in: PubMed
    45. Tyszka JM, Fraser SE, Jacobs R. Magnetic resonance microscopy: recent advances and applications. Curr Opin Biotechnol. 2005 Feb; 16(1):93-9. PMID: 15722021.
      View in: PubMed
    46. MacKenzie-Graham A, Lee EF, Dinov ID, Bota M, Shattuck DW, Ruffins S, Yuan H, Konstantinidis F, Pitiot A, Ding Y, Hu G, Jacobs R, Toga AW. A multimodal, multidimensional atlas of the C57BL/6J mouse brain. J Anat. 2004 Feb; 204(2):93-102. PMID: 15032916; PMCID: PMC1571243.
    47. Jacobs R, Papan C, Ruffins S, Tyszka JM, Fraser SE. MRI: volumetric imaging for vital imaging and atlas construction. Nat Rev Mol Cell Biol. 2003 Sep; Suppl:SS10-6. PMID: 14587521.
      View in: PubMed
    48. Pautler RG, Mongeau R, Jacobs R. In vivo trans-synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI). Magn Reson Med. 2003 Jul; 50(1):33-9. PMID: 12815676.
      View in: PubMed
    49. Redwine JM, Kosofsky B, Jacobs R, Games D, Reilly JF, Morrison JH, Young WG, Bloom FE. Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1381-6. PMID: 12552120; PMCID: PMC298781.
    50. Gardner D, Toga AW, Ascoli GA, Beatty JT, Brinkley JF, Dale AM, Fox PT, Gardner EP, George JS, Goddard N, Harris KM, Herskovits EH, Hines ML, Jacobs GA, Jacobs R, Jones EG, Kennedy DN, Kimberg DY, Mazziotta JC, Miller PL, Mori S, Mountain DC, Reiss AL, Rosen GD, Rottenberg DA, Shepherd GM, Smalheiser NR, Smith KP, Strachan T, Van Essen DC, Williams RW, Wong ST. Towards effective and rewarding data sharing. Neuroinformatics. 2003; 1(3):289-95. PMID: 15046250.
      View in: PubMed
    51. Ruffins SW, Jacobs R, Fraser SE. Towards a Tralfamadorian view of the embryo: multidimensional imaging of development. Curr Opin Neurobiol. 2002 Oct; 12(5):580-6. PMID: 12367639.
      View in: PubMed
    52. Dhenain M, Privat N, Duyckaerts C, Jacobs R. Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images. NMR Biomed. 2002 May; 15(3):197-203. PMID: 11968135.
      View in: PubMed
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