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Kai Chen, PhD

Title(s)Associate Professor Of Research Radiology
Phone+1 323 442 3582
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li Y, Zhang J, Gu J, Hu K, Huang S, Conti PS, Wu H, Chen K. Radiofluorinated GPC3-Binding Peptides for PET Imaging of Hepatocellular Carcinoma. Mol Imaging Biol. 2020 Feb; 22(1):134-143. PMID: 31044341.
      View in: PubMed
    2. Liu M, Anderson RC, Lan X, Conti PS, Chen K. Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer. Med Res Rev. 2019 Oct 25. PMID: 31650619.
      View in: PubMed
    3. Jadvar H, Chen K, Park R, Yap LP, Vorobyova I, Swenson S, Markland FS. Preclinical evaluation of a 64Cu-labeled disintegrin for PET imaging of prostate cancer. Amino Acids. 2019 Nov; 51(10-12):1569-1575. PMID: 31621030.
      View in: PubMed
    4. Li J, Van Valkenburgh J, Hong X, Conti PS, Zhang X, Chen K. Small molecules as theranostic agents in cancer immunology. Theranostics. 2019; 9(25):7849-7871. PMID: 31695804.
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    5. Li J, Hong X, Li G, Conti PS, Zhang X, Chen K. PET Imaging of Adenosine Receptors in Diseases. Curr Top Med Chem. 2019; 19(16):1445-1463. PMID: 31284861.
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    6. Zhu J, Li H, Xiong Z, Shen M, Conti PS, Shi X, Chen K. Polyethyleneimine-Coated Manganese Oxide Nanoparticles for Targeted Tumor PET/MR Imaging. ACS Appl Mater Interfaces. 2018 Oct 17; 10(41):34954-34964. PMID: 30234287.
      View in: PubMed
    7. Wang F, Yang P, Choi JS, Antovski P, Zhu Y, Xu X, Kuo TH, Lin LE, Kim DNH, Huang PC, Xu H, Lee CF, Wang C, Hsu CC, Chen K, Weiss PS, Tseng HR. Cross-Linked Fluorescent Supramolecular Nanoparticles for Intradermal Controlled Release of Antifungal Drug-A Therapeutic Approach for Onychomycosis. ACS Nano. 2018 07 24; 12(7):6851-6859. PMID: 29851454.
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    8. Wang X, Zhang J, Wu H, Li Y, Conti PS, Chen K. PET imaging of Hsp90 expression in pancreatic cancer using a new 64Cu-labeled dimeric Sansalvamide A decapeptide. Amino Acids. 2018 Jul; 50(7):897-907. PMID: 29691700.
      View in: PubMed
    9. Ma W, Fu F, Zhu J, Huang R, Zhu Y, Liu Z, Wang J, Conti PS, Shi X, Chen K. 64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging. Nanoscale. 2018 Mar 29; 10(13):6113-6124. PMID: 29547220.
      View in: PubMed
    10. Zhu G, Lynn GM, Jacobson O, Chen K, Liu Y, Zhang H, Ma Y, Zhang F, Tian R, Ni Q, Cheng S, Wang Z, Lu N, Yung BC, Wang Z, Lang L, Fu X, Jin A, Weiss ID, Vishwasrao H, Niu G, Shroff H, Klinman DM, Seder RA, Chen X. Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy. Nat Commun. 2017 12 05; 8(1):1954. PMID: 29203865.
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    11. Zhang F, Zhu G, Jacobson O, Liu Y, Chen K, Yu G, Ni Q, Fan J, Yang Z, Xu F, Fu X, Wang Z, Ma Y, Niu G, Zhao X, Chen X. Transformative Nanomedicine of an Amphiphilic Camptothecin Prodrug for Long Circulation and High Tumor Uptake in Cancer Therapy. ACS Nano. 2017 09 26; 11(9):8838-8848. PMID: 28858467.
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    12. Jadvar H, Park R, Yap LP, Chen K, Hughes L, Conti P. Effect of Androgen on Normal Biodistribution of [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in Athymic Non-tumor-bearing Male Mice. Anticancer Res. 2017 02; 37(2):475-479. PMID: 28179292.
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    13. Choi JS, Zhu Y, Li H, Peyda P, Nguyen TT, Shen MY, Yang YM, Zhu J, Liu M, Lee MM, Sun SS, Yang Y, Yu HH, Chen K, Chuang GS, Tseng HR. Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times. ACS Nano. 2017 01 24; 11(1):153-162. PMID: 27997116.
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    14. Ma W, Shao Y, Yang W, Li G, Zhang Y, Zhang M, Zuo C, Chen K, Wang J. Evaluation of (188)Re-labeled NGR-VEGI protein for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts. Tumour Biol. 2016 Jul; 37(7):9121-9. PMID: 26768609.
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    15. Hou S, Choi JS, Garcia MA, Xing Y, Chen KJ, Chen YM, Jiang ZK, Ro T, Wu L, Stout DB, Tomlinson JS, Wang H, Chen K, Tseng HR, Lin WY. Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry. ACS Nano. 2016 Jan 26; 10(1):1417-24. PMID: 26731174.
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    16. Huang R, Conti PS, Chen K. In Vivo Tumor Angiogenesis Imaging Using Peptide-Based Near-Infrared Fluorescent Probes. Methods Mol Biol. 2016; 1444:73-84. PMID: 27283419.
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    17. Liu Z, Chen H, Chen K, Shao Y, Kiesewetter DO, Niu G, Chen X. Boramino acid as a marker for amino acid transporters. Sci Adv. 2015 Sep; 1(8):e1500694. PMID: 26601275.
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    18. Jadvar H, Chen K, Ukimura O. Targeted Prostate Gland Biopsy With Combined Transrectal Ultrasound, mpMRI, and 18F-FMAU PET/CT. Clin Nucl Med. 2015 Aug; 40(8):e426-8. PMID: 26018690.
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    19. Huang R, Wang M, Zhu Y, Conti PS, Chen K. Development of PET probes for cancer imaging. Curr Top Med Chem. 2015; 15(8):795-819. PMID: 25732787.
      View in: PubMed
    20. Ma W, Li G, Wang J, Yang W, Zhang Y, Conti PS, Chen K. In vivo NIRF imaging-guided delivery of a novel NGR-VEGI fusion protein for targeting tumor vasculature. Amino Acids. 2014 Dec; 46(12):2721-32. PMID: 25182731.
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    21. Cheng Y, Zhao J, Qiao W, Chen K. Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates. Am J Nucl Med Mol Imaging. 2014; 4(5):385-405. PMID: 25143859.
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    22. Shao Y, Liang W, Kang F, Yang W, Ma X, Li G, Zong S, Chen K, Wang J. 68Ga-labeled cyclic NGR peptide for microPET imaging of CD13 receptor expression. Molecules. 2014 Aug 05; 19(8):11600-12. PMID: 25100253.
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    23. Li G, Wang X, Zong S, Wang J, Conti PS, Chen K. MicroPET imaging of CD13 expression using a (64)Cu-labeled dimeric NGR peptide based on sarcophagine cage. Mol Pharm. 2014 Nov 03; 11(11):3938-46. PMID: 25054774.
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    24. Shao Y, Liang W, Kang F, Yang W, Ma X, Li G, Zong S, Chen K, Wang J. A direct comparison of tumor angiogenesis with 68Ga-labeled NGR and RGD peptides in HT-1080 tumor xenografts using microPET imaging. Amino Acids. 2014 Oct; 46(10):2355-64. PMID: 24990522.
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    25. Li G, Xing Y, Wang J, Conti PS, Chen K. Near-infrared fluorescence imaging of CD13 receptor expression using a novel Cy5.5-labeled dimeric NGR peptide. Amino Acids. 2014 Jun; 46(6):1547-56. PMID: 24652439.
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    26. Xing Y, Zhao J, Conti PS, Chen K. Radiolabeled nanoparticles for multimodality tumor imaging. Theranostics. 2014; 4(3):290-306. PMID: 24505237.
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    27. Ma W, Kang F, Wang Z, Yang W, Li G, Ma X, Li G, Chen K, Zhang Y, Wang J. (99m)Tc-labeled monomeric and dimeric NGR peptides for SPECT imaging of CD13 receptor in tumor-bearing mice. Amino Acids. 2013 May; 44(5):1337-45. PMID: 23456486.
      View in: PubMed
    28. Chen K, Ma W, Li G, Wang J, Yang W, Yap LP, Hughes LD, Park R, Conti PS. Synthesis and evaluation of 64Cu-labeled monomeric and dimeric NGR peptides for MicroPET imaging of CD13 receptor expression. Mol Pharm. 2013 Jan 07; 10(1):417-27. PMID: 23190134.
      View in: PubMed
    29. Li G, Xiang L, Yang W, Wang Z, Wang J, Chen K. Efficient multicistronic co-expression of hNIS and hTPO in prostate cancer cells for nonthyroidal tumor radioiodine therapy. Am J Nucl Med Mol Imaging. 2012; 2(4):483-98. PMID: 23145364.
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    30. Chen K, Wang X, Lin WY, Shen CK, Yap LP, Hughes LD, Conti PS. Strain-Promoted Catalyst-Free Click Chemistry for Rapid Construction of (64)Cu-Labeled PET Imaging Probes. ACS Med Chem Lett. 2012 Dec 13; 3(12):1019-23. PMID: 24900423.
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    31. Jadvar H, Yap LP, Park R, Li Z, Chen K, Hughes L, Kouhi A, Conti P. [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations. Mol Imaging. 2012 Sep-Oct; 11(5):426-32. PMID: 22954187.
      View in: PubMed
    32. Chen K, Li Z, Conti PS. Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-ß-d-arabinofuranosyluracil ([18F]-FMAU). Nucl Med Biol. 2012 Oct; 39(7):1019-25. PMID: 22503457.
      View in: PubMed
    33. Chen K, Sun X, Niu G, Ma Y, Yap LP, Hui X, Wu K, Fan D, Conti PS, Chen X. Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature. Mol Imaging Biol. 2012 Feb; 14(1):96-105. PMID: 21360213.
      View in: PubMed
    34. Huang CW, Li Z, Cai H, Chen K, Shahinian T, Conti PS. Design, synthesis and validation of integrin a2ß1-targeted probe for microPET imaging of prostate cancer. Eur J Nucl Med Mol Imaging. 2011 Jul; 38(7):1313-22. PMID: 21350963.
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    35. Chen K, Chen X. Integrin targeted delivery of chemotherapeutics. Theranostics. 2011 Feb 17; 1:189-200. PMID: 21547159.
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    36. Chen K, Chen X. Positron emission tomography imaging of cancer biology: current status and future prospects. Semin Oncol. 2011 Feb; 38(1):70-86. PMID: 21362517.
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    37. Chen K, Yap LP, Park R, Hui X, Wu K, Fan D, Chen X, Conti PS. A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice. Amino Acids. 2012 Apr; 42(4):1329-37. PMID: 21212998.
      View in: PubMed
    38. Chen K, Conti PS. Target-specific delivery of peptide-based probes for PET imaging. Adv Drug Deliv Rev. 2010 Aug 30; 62(11):1005-22. PMID: 20851156.
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    39. Sun X, Niu G, Yan Y, Yang M, Chen K, Ma Y, Chan N, Shen B, Chen X. Phage display-derived peptides for osteosarcoma imaging. Clin Cancer Res. 2010 Aug 15; 16(16):4268-77. PMID: 20570932.
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    40. Anderson CJ, Bulte JW, Chen K, Chen X, Khaw BA, Shokeen M, Wooley KL, VanBrocklin HF. Design of targeted cardiovascular molecular imaging probes. J Nucl Med. 2010 May 01; 51 Suppl 1:3S-17S. PMID: 20395345.
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    41. Chen K, Chen X. Design and development of molecular imaging probes. Curr Top Med Chem. 2010; 10(12):1227-36. PMID: 20388106.
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