Dongshi Chen

Title(s)Assistant Professor of Research Medicine
SchoolKeck School of Medicine of Usc
Address1520 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
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    Collapse Biography 
    Collapse Education and Training
    Fuzhou University, ChinaBS07/2003Bioengineering
    Xiamen University, ChinaMS07/2006Biochemistry
    Chinese University of Hong Kong, Hong KongPhD08/2010Biochemistry
    University of Pittsburgh, Pittsburg06/2018Postdoc, Department of Pharmacology and Chemical Biology

    Collapse Overview 
    Collapse Overview
    Dr. Chen's current research focuses on the signal pathway of cell death and its role and functional mechanism in cigarette smoking induced lung injury and inflammation, as well as their correlation with lung diseases, such as COPD, lung cancer.

    His current studies engaged into the interplay of apoptosis, necroptosis, and lung inflammatory response, including activation of macrophage, neutrophil and T cells. On the other hand, he is interested in studying how elastases (ELANE, MMP12, et al) released in the inflammatory microenvironment contribute to the progression of COPD and lung cancer.

    The long term goal is to identify novel molecular targets and treatment strategies to improve COPD, lung cancer therapy. He is also interested in studying the role and molecular mechanisms of aging in the progression of COPD and tumorigenesis.

    Collapse Research 
    Collapse Research Activities and Funding
    UPMC ITTC Award
    Nov 1, 2020 - Oct 30, 2021
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease. JCI Insight. 2021 06 22; 6(12). Chen D, Gregory AD, Li X, Wei J, Burton CL, Gibson G, Scott SJ, St Croix CM, Zhang Y, Shapiro SD. PMID: 34156033; PMCID: PMC8262480.
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    2. RNA m6 A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy. EMBO J. 2020 06 17; 39(12):e103181. Lin Z, Niu Y, Wan A, Chen D, Liang H, Chen X, Sun L, Zhan S, Chen L, Cheng C, Zhang X, Bu X, He W, Wan G. PMID: 32368828; PMCID: PMC7298296.
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    3. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019 05; 69(5):2164-2179. Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L. PMID: 30552702; PMCID: PMC6461480.
      View in: PubMed   Mentions:
    4. Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene. 2018 08; 37(33):4599-4610. Knickelbein K, Tong J, Chen D, Wang YJ, Misale S, Bardelli A, Yu J, Zhang L. PMID: 29755130; PMCID: PMC6195818.
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    5. PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3930-3935. Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L. PMID: 29581256; PMCID: PMC5899441.
      View in: PubMed   Mentions:
    6. Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 05 01; 77(9):2512-2521. Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L. PMID: 28202514; PMCID: PMC5626525.
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    7. BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. Oncotarget. 2016 Jul 26; 7(30):47699-47710. He K, Chen D, Ruan H, Li X, Tong J, Xu X, Zhang L, Yu J. PMID: 27351224; PMCID: PMC5216972.
      View in: PubMed   Mentions:
    8. Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta. 2016 Apr; 1865(2):228-36. Chen D, Yu J, Zhang L. PMID: 26968619; PMCID: PMC4860077.
      View in: PubMed   Mentions:
    9. Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 2015 Jun 20; 6(17):15022-34. Chen X, Song X, Yue W, Chen D, Yu J, Yao Z, Zhang L. PMID: 25909283; PMCID: PMC4558133.
      View in: PubMed   Mentions:
    10. Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. Cell Death Dis. 2015 Apr 23; 6:e1729. Brown MF, Leibowitz BJ, Chen D, He K, Zou F, Sobol RW, Beer-Stolz D, Zhang L, Yu J. PMID: 25906152; PMCID: PMC4650537.
      View in: PubMed   Mentions:
    11. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014 Sep 30; 5(18):8107-22. Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, Zhang L. PMID: 25237903; PMCID: PMC4226670.
      View in: PubMed   Mentions:
    12. Understanding copper sensitivity in zebrafish (Danio rerio) through the intracellular localization of copper transporters in a hepatocyte cell-line ZFL and the tissue expression profiles of copper transporters. Metallomics. 2014 May; 6(5):1057-67. Leung KP, Chen D, Chan KM. PMID: 24658744.
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    13. Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis. Clin Cancer Res. 2014 Jul 01; 20(13):3472-84. Chen D, Wei L, Yu J, Zhang L. PMID: 24763611; PMCID: PMC4079733.
      View in: PubMed   Mentions:
    14. Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells. Mol Cancer Ther. 2014 May; 13(5):1298-308. Sun J, Knickelbein K, He K, Chen D, Dudgeon C, Shu Y, Yu J, Zhang L. PMID: 24563542; PMCID: PMC4013266.
      View in: PubMed   Mentions:
    15. Identification of hepatic copper-binding proteins from tilapia by column chromatography with proteomic approaches. Metallomics. 2012 Aug; 4(8):820-34. Chen D, Chan KM. PMID: 22699969.
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    16. PCR-cloning of tilapia ATP7A cDNA and its mRNA levels in tissues of tilapia following copper administrations. Aquat Toxicol. 2011 Oct; 105(3-4):717-27. Chen DS, Chan KM. PMID: 21996258.
      View in: PubMed   Mentions:
    17. Effects of Cu2O nanoparticle and CuCl2 on zebrafish larvae and a liver cell-line. Aquat Toxicol. 2011 Oct; 105(3-4):344-54. Chen D, Zhang D, Yu JC, Chan KM. PMID: 21839701.
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    18. Differentially expressed proteins in zebrafish liver cells exposed to copper. Aquat Toxicol. 2011 Aug; 104(3-4):270-7. Chen DS, Chan KM. PMID: 21641295.
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    19. Changes in the protein expression profiles of the Hepa-T1 cell line when exposed to Cu2+. Aquat Toxicol. 2009 Sep 14; 94(3):163-76. Chen DS, Chan KM. PMID: 19616320.
      View in: PubMed   Mentions:
    20. Differential Proteins of Sub-buccal Ganglions Selected and Identified with Proteomic Techniques in Aplysia Under the Stress Condition of Cadmium Chloride. Chemical Journal of Chinese Universities-Chinese. 2009; 30:314-319. Huang L, Chen DS, Yan L, Fang CW, Huang HQ. View Publication.
    21. Biokinetics of cadmium and zinc in a marine bacterium: influences of metal interaction and pre-exposure. Environ Toxicol Chem. 2008 Aug; 27(8):1794-801. Chen D, Qian PY, Wang WX. PMID: 18384227.
      View in: PubMed   Mentions:
    22. Proteomic study of serum using gel chromatography and MALDI-TOF-MS reveals diagnostic biomarkers in male patients with liver cancer. International Journal of Mass Spectrometry. 2007; 261(2-3):108-114. Zeng XH, Huang HQ, Chen DS, Jin HW, Huang HY. View Publication.
    23. Optimized Separation and Identification of Proteome from the Baccal Ganalion of Aplysia (Notarcus leachii cirrosus Stimpson). Chemical Journal of Chinese Universities-Chinese. 2006; 27:1257-1261. Chen DS, Huang HQ, Wu HZ, Zong C. View Publication.
    24. Polymer Characteristics of Catechin and Catechin Ge4 Measured with a Technology of Mass Spectrometry. Chinese Journal of Analytical Chemistry. 2006; 1:52-56. Huang H, Hu X, Huang H, Yan L, Chen D, Ouyang G, Zhuo H.
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