Jian Yu

Title(s)Professor of Medicine
SchoolKeck School of Medicine of Usc
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0002-4021-1000 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Sichuan University, Chengdu, ChinaBS07/1991Chemistry
    Johns Hopkins University, Baltimore, USAPhD05/2001Human Genetics and Molecular Biology
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, USAFellowship, postdoctoral06/2002Oncology
    Collapse Awards and Honors
    Johns Hopkins University School of Medicine2001Michael A. Shanoff Research Excellence Award
    The Flight Attendant Medical Research Institute2003Young Clinical Scientist Award
    The Hillman Foundation2004The Hillman Fellow of Innovative Cancer Research
    The Alliance for Cancer Gene Therapy 2005Young Investigator Award
    University of Pittsburgh Cancer Institute2008Junior Scholar Award
    American Cancer Society2010Research Scholar Award
    University of Pittsburgh2011Innovator Award

    Collapse Overview 
    Collapse Overview
    My research explores mechanistic coupling of intestinal stem cell injury with regeneration, focusing on cancer driver-dependent regulation of cell death, stress adaptation, and immunologic outcomes. Our long-term goal is to identify novel targets and agents for colon cancer prevention and treatment through stem cell and niche normalization and epithelial barrier longevity. I have been active in teaching and mentoring students, postdoctoral fellows, and junior faculty.

    Publications
    -My NCBI, https://www.ncbi.nlm.nih.gov/myncbi/jian.yu.1/bibliography/public/

    -Google Scholar, 143 papers, over 25,000 citations, h-index 70 (2023)
    http://scholar.google.com/citations?user=PfNbw24AAAAJ&hl=en

    Collapse Research 
    Collapse Research Activities and Funding
    LR-IL-22 for Mitigation and Management of Radiation Injuries
    NIH/NIAID U01 AI172885Dec 1, 2022 - Nov 30, 2027
    Role: Co-Investigator
    STING-dependent Intestinal Regeneration upon Radiation Injury
    NIH/NCI R01CA260900Feb 9, 2022 - Jan 31, 2027
    Role: Principal Investigator
    BET degraders for improving colorectal cancer therapy
    NIH/NCI R01CA248112Apr 1, 2021 - Mar 31, 2026
    Role: Co-Investigator
    Targeting defective necroptosis in colorectal cancer
    NIH/NCI R01CA247231Dec 1, 2019 - Nov 30, 2024
    Role: Co-Principle Investigator, MPI
    Translation addiction and targeting in colon cancer
    NIH/NCI R01CA215481Jan 1, 2018 - Mar 31, 2023
    Role: Principle Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death. Oncogene. 2023 Jun; 42(24):2007-2016. Leibowitz BJ, Zhao G, Xia W, Wang Y, Ruan H, Zhang L, Yu J. PMID: 37138032; PMCID: PMC10256613.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Targeting Myc-driven stress addiction in colorectal cancer. Drug Resist Updat. 2023 Jul; 69:100963. Saeed H, Leibowitz BJ, Zhang L, Yu J. PMID: 37119690; PMCID: PMC10330748.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Release of Interferon-β (IFN-β) from Probiotic Limosilactobacillus reuteri-IFN-β (LR-IFN-β) Mitigates Gastrointestinal Acute Radiation Syndrome (GI-ARS) following Whole Abdominal Irradiation. Cancers (Basel). 2023 Mar 08; 15(6). Hamade DF, Epperly MW, Fisher R, Hou W, Shields D, van Pijkeren JP, Mukherjee A, Yu J, Leibowitz BJ, Vlad AM, Coffman L, Wang H, Huq MS, Huang Z, Rogers CJ, Greenberger JS. PMID: 36980556; PMCID: PMC10046795.
      View in: PubMed   Mentions: 2  
    4. Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction. Oncogene. 2023 03; 42(12):869-880. Tong J, Tan X, Hao S, Ermine K, Lu X, Liu Z, Jha A, Yu J, Zhang L. PMID: 36721000; PMCID: PMC10364554.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer. Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2211775119. Hao S, Tong J, Jha A, Risnik D, Lizardo D, Lu X, Goel A, Opresko PL, Yu J, Zhang L. PMID: 36508676; PMCID: PMC9907101.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    6. Dual inhibition of BET and HAT/p300 suppresses colorectal cancer via DR5- and p53/PUMA-mediated cell death. Front Oncol. 2022; 12:1018775. Kuang C, Tong J, Ermine K, Cai M, Dai F, Hao S, Giles F, Huang Y, Yu J, Zhang L. PMID: 36313707; PMCID: PMC9599411.
      View in: PubMed   Mentions: 3  
    7. Lactobacillus reuteri Releasing IL-22 (LR-IL-22) Facilitates Intestinal Radioprotection for Whole-Abdomen Irradiation (WAI) of Ovarian Cancer. Radiat Res. 2022 07 01; 198(1):89-105. Hamade DF, Espinal A, Yu J, Leibowitz BJ, Fisher R, Hou W, Shields D, van Pijkeren JP, Mukherjee A, Epperly MW, Vlad AM, Coffman L, Wang H, Saiful Huq M, Patel R, Huang J, Greenberger JS. PMID: 35446961; PMCID: PMC9278541.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    8. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022 04 01; 82(7):1340-1352. Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. PMID: 35149588; PMCID: PMC8983601.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    9. Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer. Mol Biomed. 2022 Mar 21; 3(1):10. Ruan H, Leibowitz BJ, Peng Y, Shen L, Chen L, Kuang C, Schoen RE, Lu X, Zhang L, Yu J. PMID: 35307764; PMCID: PMC8934835.
      View in: PubMed   Mentions: 4  
    10. tRF3008A suppresses the progression and metastasis of colorectal cancer by destabilizing FOXK1 in an AGO-dependent manner. J Exp Clin Cancer Res. 2022 Jan 22; 41(1):32. Han Y, Peng Y, Liu S, Wang X, Cai C, Guo C, Chen Y, Gao L, Huang Q, He M, Shen E, Long J, Yu J, Shen H, Zeng S. PMID: 35065674; PMCID: PMC8783529.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    11. Role of Receptor Interacting Protein (RIP) kinases in cancer. Genes Dis. 2022 Nov; 9(6):1579-1593. Ermine K, Yu J, Zhang L. PMID: 36157481; PMCID: PMC9485196.
      View in: PubMed   Mentions: 6  
    12. Interferon b drives intestinal regeneration after radiation. Sci Adv. 2021 Oct 08; 7(41):eabi5253. Leibowitz BJ, Zhao G, Wei L, Ruan H, Epperly M, Chen L, Lu X, Greenberger JS, Zhang L, Yu J. PMID: 34613772; PMCID: PMC8494436.
      View in: PubMed   Mentions: 13     Fields:    
    13. BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade. Oncogene. 2021 12; 40(48):6566-6578. Tong J, Tan X, Risnik D, Gao M, Song X, Ermine K, Shen L, Wang S, Yu J, Zhang L. PMID: 34615996; PMCID: PMC8642302.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    14. M6A "Writer" Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer. Front Oncol. 2021; 11:615296. Cai C, Long J, Huang Q, Han Y, Peng Y, Guo C, Liu S, Chen Y, Shen E, Long K, Wang X, Yu J, Shen H, Zeng S. PMID: 34221955; PMCID: PMC8247640.
      View in: PubMed   Mentions: 14  
    15. Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis. Oncogene. 2021 03; 40(11):2035-2050. Fletcher R, Tong J, Risnik D, Leibowitz BJ, Wang YJ, Concha-Benavente F, DeLiberty JM, Stolz DB, Pai RK, Ferris RL, Schoen RE, Yu J, Zhang L. PMID: 33603166; PMCID: PMC7981263.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer. J Exp Clin Cancer Res. 2020 Dec 02; 39(1):270. Hu XT, Xing W, Zhao RS, Tan Y, Wu XF, Ao LQ, Li Z, Yao MW, Yuan M, Guo W, Li SZ, Yu J, Ao X, Xu X. PMID: 33267897; PMCID: PMC7709355.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    17. eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis. Elife. 2020 11 02; 9. Ruan H, Li X, Xu X, Leibowitz BJ, Tong J, Chen L, Ao L, Xing W, Luo J, Yu Y, Schoen RE, Sonenberg N, Lu X, Zhang L, Yu J. PMID: 33135632; PMCID: PMC7665890.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside. Biochim Biophys Acta Rev Cancer. 2020 12; 1874(2):188447. Lizardo DY, Kuang C, Hao S, Yu J, Huang Y, Zhang L. PMID: 33035640; PMCID: PMC7886024.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    19. Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer. Theranostics. 2020; 10(18):8098-8110. Song X, Shen L, Tong J, Kuang C, Zeng S, Schoen RE, Yu J, Pei H, Zhang L. PMID: 32724460; PMCID: PMC7381732.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    20. MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her-2/PI3K/AKT Signaling. Adv Sci (Weinh). 2020 Jul; 7(13):2000112. Han Y, Peng Y, Fu Y, Cai C, Guo C, Liu S, Li Y, Chen Y, Shen E, Long K, Wang X, Yu J, Shen H, Zeng S. PMID: 32670759; PMCID: PMC7341094.
      View in: PubMed   Mentions: 22     Fields:    
    21. Immunogenic cell death in colon cancer prevention and therapy. Mol Carcinog. 2020 07; 59(7):783-793. Ruan H, Leibowitz BJ, Zhang L, Yu J. PMID: 32215970; PMCID: PMC7593824.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    22. Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis. Radiat Res. 2020 05; 193(5):435-450. Thermozier S, Hou W, Zhang X, Shields D, Fisher R, Bayir H, Kagan V, Yu J, Liu B, Bahar I, Epperly MW, Wipf P, Wang H, Huq MS, Greenberger JS. PMID: 32134361; PMCID: PMC7299160.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsPHPublic Health
    23. PUMA-mediated epithelial cell apoptosis promotes Helicobacter pylori infection-mediated gastritis. Cell Death Dis. 2020 02 20; 11(2):139. Dang Y, Zhang Y, Xu L, Zhou X, Gu Y, Yu J, Jin S, Ji H, Shu Y, Zhang G, Cui S, Sun J. PMID: 32080167; PMCID: PMC7033162.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation. In Vivo. 2020 Jan-Feb; 34(1):39-50. Zhang X, Fisher R, Hou W, Shields D, Epperly MW, Wang H, Wei L, Leibowitz BJ, Yu J, Alexander LM, VAN Pijkeren JP, Watkins S, Wipf P, Greenberger JS. PMID: 31882461; PMCID: PMC6984118.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    25. Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases. Nat Commun. 2019 07 18; 10(1):3190. Sun J, Wang C, Zhang Y, Xu L, Fang W, Zhu Y, Zheng Y, Chen X, Xie X, Hu X, Hu W, Zheng J, Li P, Yu J, Mei Z, Cai X, Wang B, Hu Z, Shu Y, Shen H, Gu Y. PMID: 31320627; PMCID: PMC6639368.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    26. Landscape perspectives of tumor, EMT, and development. Phys Biol. 2019 07 05; 16(5):051003. Yu C, Liu Q, Chen C, Yu J, Wang J. PMID: 31067516.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019 05; 69(5):2164-2179. Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L. PMID: 30552702; PMCID: PMC6461480.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    28. BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5. Cancer Res. 2019 03 15; 79(6):1191-1203. Tan X, Tong J, Wang YJ, Fletcher R, Schoen RE, Yu J, Shen L, Zhang L. PMID: 30674532; PMCID: PMC6420862.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    29. Metformin induces apoptosis in mesenchymal stromal cells and dampens their therapeutic efficacy in infarcted myocardium. Stem Cell Res Ther. 2018 11 08; 9(1):306. He X, Yao MW, Zhu M, Liang DL, Guo W, Yang Y, Zhao RS, Ren TT, Ao X, Wang W, Zeng CY, Liang HP, Jiang DP, Yu J, Xu X. PMID: 30409193; PMCID: PMC6225675.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    30. Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5. J Cell Biochem. 2019 01; 120(1):928-939. Lee YS, Lee DH, Jeong SY, Park SH, Oh SC, Park YS, Yu J, Choudry HA, Bartlett DL, Lee YJ. PMID: 30160785; PMCID: PMC6249082.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    31. Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. Cancer Res. 2018 08 15; 78(16):4704-4715. Tong J, Zheng X, Tan X, Fletcher R, Nikolovska-Coleska Z, Yu J, Zhang L. PMID: 29895675; PMCID: PMC6298746.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    32. Immunogenic effects of chemotherapy-induced tumor cell death. Genes Dis. 2018 Sep; 5(3):194-203. Wang YJ, Fletcher R, Yu J, Zhang L. PMID: 30320184; PMCID: PMC6176216.
      View in: PubMed   Mentions: 140  
    33. Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene. 2018 08; 37(33):4599-4610. Knickelbein K, Tong J, Chen D, Wang YJ, Misale S, Bardelli A, Yu J, Zhang L. PMID: 29755130; PMCID: PMC6195818.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    34. PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3930-3935. Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L. PMID: 29581256; PMCID: PMC5899441.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    35. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018 02 07; 10(427). Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. PMID: 29437148; PMCID: PMC5827930.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    36. Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta Rev Cancer. 2018 Apr; 1869(2):138-148. Fletcher R, Wang YJ, Schoen RE, Finn OJ, Yu J, Zhang L. PMID: 29391185; PMCID: PMC5955808.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    37. γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue. Molecules. 2017 Dec 02; 22(12). Orenstein A, Berlyoung AS, Rastede EE, Pham HH, Fouquerel E, Murphy CT, Leibowitz BJ, Yu J, Srivastava T, Armitage BA, Opresko PL. PMID: 29207465; PMCID: PMC5895088.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    38. Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res. 2018 01; 189(1):68-83. Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS. PMID: 29140165; PMCID: PMC5808408.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    39. FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. Mol Cancer Ther. 2017 09; 16(9):1979-1988. Tong J, Tan S, Nikolovska-Coleska Z, Yu J, Zou F, Zhang L. PMID: 28619760; PMCID: PMC5587378.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    40. Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications. Diabetologia. 2017 Sep; 60(9):1822-1833. Zhu M, He X, Wang XH, Qiu W, Xing W, Guo W, An TC, Ao LQ, Hu XT, Li Z, Liu XP, Xiao N, Yu J, Huang H, Xu X. PMID: 28577176.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    41. Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 05 01; 77(9):2512-2521. Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L. PMID: 28202514; PMCID: PMC5626525.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    42. Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. Oncotarget. 2017 Feb 07; 8(6):9280-9292. Li X, Li M, Ruan H, Qiu W, Xu X, Zhang L, Yu J. PMID: 28030835; PMCID: PMC5354731.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    43. Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation. Sci Rep. 2017 02 01; 7:41892. Vendetti FP, Leibowitz BJ, Barnes J, Schamus S, Kiesel BF, Abberbock S, Conrads T, Clump DA, Cadogan E, O'Connor MJ, Yu J, Beumer JH, Bakkenist CJ. PMID: 28145510; PMCID: PMC5286430.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsPHPublic Health
    44. Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. J Clin Invest. 2016 11 01; 126(11):4076-4087. Wei L, Leibowitz BJ, Wang X, Epperly M, Greenberger J, Zhang L, Yu J. PMID: 27701148; PMCID: PMC5096907.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCellsPHPublic Health
    45. BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. Oncotarget. 2016 Jul 26; 7(30):47699-47710. He K, Chen D, Ruan H, Li X, Tong J, Xu X, Zhang L, Yu J. PMID: 27351224; PMCID: PMC5216972.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    46. FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. Oncogene. 2017 02 09; 36(6):787-796. Tong J, Tan S, Zou F, Yu J, Zhang L. PMID: 27399335; PMCID: PMC5226932.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    47. Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell. 2016 08; 15(4):646-60. Wang Y, Wang X, Flores ER, Yu J, Chang S. PMID: 27113195; PMCID: PMC4933665.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    48. Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta. 2016 Apr; 1865(2):228-36. Chen D, Yu J, Zhang L. PMID: 26968619; PMCID: PMC4860077.
      View in: PubMed   Mentions: 84     Fields:    Translation:Humans
    49. Early Prediction of Cancer Progression by Depth-Resolved Nanoscale Mapping of Nuclear Architecture from Unstained Tissue Specimens. Cancer Res. 2015 Nov 15; 75(22):4718-27. Uttam S, Pham HV, LaFace J, Leibowitz B, Yu J, Brand RE, Hartman DJ, Liu Y. PMID: 26383164; PMCID: PMC4651746.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    50. Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 2015 Jun 20; 6(17):15022-34. Chen X, Song X, Yue W, Chen D, Yu J, Yao Z, Zhang L. PMID: 25909283; PMCID: PMC4558133.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    51. Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. Cell Death Dis. 2015 Apr 23; 6:e1729. Brown MF, Leibowitz BJ, Chen D, He K, Zou F, Sobol RW, Beer-Stolz D, Zhang L, Yu J. PMID: 25906152; PMCID: PMC4650537.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    52. mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation. Oncogene. 2016 Jan 14; 35(2):148-57. He K, Zheng X, Li M, Zhang L, Yu J. PMID: 25867072; PMCID: PMC4603992.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    53. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10; 5:8566. Wang X, Wei L, Cramer JM, Leibowitz BJ, Judge C, Epperly M, Greenberger J, Wang F, Li L, Stelzner MG, Dunn JCY, Martin MG, Lagasse E, Zhang L, Yu J. PMID: 25858503; PMCID: PMC4392360.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    54. BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16520-5. Leibowitz B, Qiu W, Buchanan ME, Zou F, Vernon P, Moyer MP, Yin XM, Schoen RE, Yu J, Zhang L. PMID: 25368155; PMCID: PMC4246283.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    55. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014 Sep 30; 5(18):8107-22. Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, Zhang L. PMID: 25237903; PMCID: PMC4226670.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    56. Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems. Exp Biol Med (Maywood). 2014 Sep; 239(9):1108-23. Hartman KG, Bortner JD, Falk GW, Ginsberg GG, Jhala N, Yu J, Martín MG, Rustgi AK, Lynch JP. PMID: 24781339; PMCID: PMC4156523.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    57. Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis. Clin Cancer Res. 2014 Jul 01; 20(13):3472-84. Chen D, Wei L, Yu J, Zhang L. PMID: 24763611; PMCID: PMC4079733.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    58. Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice. Nat Commun. 2014 Mar 18; 5:3494. Leibowitz BJ, Wei L, Zhang L, Ping X, Epperly M, Greenberger J, Cheng T, Yu J. PMID: 24637717; PMCID: PMC4327858.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    59. Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells. Mol Cancer Ther. 2014 May; 13(5):1298-308. Sun J, Knickelbein K, He K, Chen D, Dudgeon C, Shu Y, Yu J, Zhang L. PMID: 24563542; PMCID: PMC4013266.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    60. Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion. Carcinogenesis. 2014 Aug; 35(8):1707-16. Chen X, Meng J, Yue W, Yu J, Yang J, Yao Z, Zhang L. PMID: 24480807; PMCID: PMC4123641.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
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    137. Differential cell cycle checkpoint response in normal human keratinocytes and fibroblasts. Cell Growth Differ. 1998 Jul; 9(7):535-43. Flatt PM, Price JO, Shaw A, Pietenpol JA. PMID: 9690621.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    138. Mutations of mitotic checkpoint genes in human cancers. Nature. 1998 Mar 19; 392(6673):300-3. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. PMID: 9521327.
      View in: PubMed   Mentions: 427     Fields:    Translation:HumansCells
    139. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 03; 95(5):2509-14. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. PMID: 9482916; PMCID: PMC19394.
      View in: PubMed   Mentions: 1254     Fields:    Translation:HumansAnimalsCells
    140. Cell-cycle arrest versus cell death in cancer therapy. Nat Med. 1997 Sep; 3(9):1034-6. Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B, Williams J. PMID: 9288734.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    141. Individual variation in recombination among human males. Am J Hum Genet. 1996 Dec; 59(6):1186-92. Yu J, Lazzeroni L, Qin J, Huang MM, Navidi W, Erlich H, Arnheim N. PMID: 8940263; PMCID: PMC1914855.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    142. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell. 1995 Jul 28; 82(2):309-19. Baker SM, Bronner CE, Zhang L, Plug AW, Robatzek M, Warren G, Elliott EA, Yu J, Ashley T, Arnheim N, Flavell RA, Liskay RM. PMID: 7628019.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    143. Studying human mutations by sperm typing: instability of CAG trinucleotide repeats in the human androgen receptor gene. Nat Genet. 1994 Aug; 7(4):531-5. Zhang L, Leeflang EP, Yu J, Arnheim N. PMID: 7951325.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
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