Lin Zhang

Title(s)Visiting Professor of Medicine
SchoolKeck School of Medicine of Usc
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0003-0018-3903 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Sichuan University, Chengdu, P.R.ChinaBS07/1990Biochemistry
    University of Southern California, Los Angeles, CAPhD05/1995Molecular Biology
    Johns Hopkins University School of Medicine, Baltimore, MDPostdoc04/1999Oncology
    Collapse Awards and Honors
    V Foundation2003  - 2005Scholar Award
    General Motors (GM) Cancer Research Foundation2003  - 2005Scholar Award
    Edward Mallinckrodt, Jr. Foundation 2003  - 2007Scholar Award
    University of Pittsburgh Cancer Institute 2006  - 2006Junior Scholar Award
    American Lung Association (ALA)/Chest Foundation2007  - 2011Career Investigator Award
    American Cancer Society (ACS)2007  - 2011Research Scholar Award
    Hillman Foundation2010  - 2010Hillman Fellow for Innovative Cancer Research
    University of Pittsburgh2011  - 2011Pitt Innovator Award

    Collapse Overview 
    Collapse Overview
    The immediate goal of our research is to understand how anticancer drugs kill cancer cells, and more importantly, why they fail so often. Our research has focused on proteins that control discrete steps of programmed cell death, including PUMA, Bax, BID, SMAC, and Mcl-1, which are directly or indirectly regulated by the most frequently mutated or altered tumor suppressors and oncogenes such as p53, APC, c-Myc and KRAS. Through analyses of these cell death regulators and their associated protein networks under the influence of oncogenic mutations and other alterations, we try to gain deep understanding on how cell death is initiated and executed in colon cancer cells, why some colon cancer cells are not sensitive to anticancer drugs, and what can be done to restore their sensitivity. Our long-term goal is to develop novel strategies and agents to improve colon cancer therapy and prevention.

    The specific projects in our lab are focused on four areas: (1) understand how cell death regulators modulate therapeutic response; (2) determine how anticancer drugs kill colon cancer cells; (3) delineate the role of cancer stem cell in cancer prevention; and (4) identify novel small molecules to target cell death regulators to improve colon cancer therapy and prevention.

    Collapse Research 
    Collapse Research Activities and Funding
    STING-dependent Intestinal Regeneration upon Radiation Injury
    NIH/NCI R01CA260900Feb 9, 2022 - Jan 31, 2027
    Role: Co-Investigator
    Developmental therapy for selectively targeting the MEK-ERK pathway in cancer cells and the tumor stromal compartment
    NIH/NCI R01CA254938Apr 7, 2021 - Mar 31, 2026
    Role: Co-Investigator
    BET degraders for improving colorectal cancer therapy
    NIH/NCI R01CA248112Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Role of LSD1 in Triple Negative Breast Cancer Development and Therapeutic Response
    NIH/NCI R01CA260357Mar 1, 2021 - Feb 28, 2026
    Role: Co-Investigator
    Targeting defective necroptosis in colorectal cancer
    NIH/NCI R01CA247231Dec 1, 2019 - Nov 30, 2024
    Role: Principal Investigator
    Role of necroptosis in colorectal cancer therapy
    NIH/NCI R01CA236271Jun 1, 2019 - May 31, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death. Oncogene. 2023 Jun; 42(24):2007-2016. Leibowitz BJ, Zhao G, Xia W, Wang Y, Ruan H, Zhang L, Yu J. PMID: 37138032; PMCID: PMC10256613.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Targeting Myc-driven stress addiction in colorectal cancer. Drug Resist Updat. 2023 Jul; 69:100963. Saeed H, Leibowitz BJ, Zhang L, Yu J. PMID: 37119690; PMCID: PMC10330748.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction. Oncogene. 2023 03; 42(12):869-880. Tong J, Tan X, Hao S, Ermine K, Lu X, Liu Z, Jha A, Yu J, Zhang L. PMID: 36721000; PMCID: PMC10364554.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer. Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2211775119. Hao S, Tong J, Jha A, Risnik D, Lizardo D, Lu X, Goel A, Opresko PL, Yu J, Zhang L. PMID: 36508676; PMCID: PMC9907101.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Dual inhibition of BET and HAT/p300 suppresses colorectal cancer via DR5- and p53/PUMA-mediated cell death. Front Oncol. 2022; 12:1018775. Kuang C, Tong J, Ermine K, Cai M, Dai F, Hao S, Giles F, Huang Y, Yu J, Zhang L. PMID: 36313707; PMCID: PMC9599411.
      View in: PubMed   Mentions: 2  
    6. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022 04 01; 82(7):1340-1352. Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. PMID: 35149588; PMCID: PMC8983601.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer. Mol Biomed. 2022 Mar 21; 3(1):10. Ruan H, Leibowitz BJ, Peng Y, Shen L, Chen L, Kuang C, Schoen RE, Lu X, Zhang L, Yu J. PMID: 35307764; PMCID: PMC8934835.
      View in: PubMed   Mentions: 3  
    8. Role of Receptor Interacting Protein (RIP) kinases in cancer. Genes Dis. 2022 Nov; 9(6):1579-1593. Ermine K, Yu J, Zhang L. PMID: 36157481; PMCID: PMC9485196.
      View in: PubMed   Mentions: 6  
    9. Interferon b drives intestinal regeneration after radiation. Sci Adv. 2021 Oct 08; 7(41):eabi5253. Leibowitz BJ, Zhao G, Wei L, Ruan H, Epperly M, Chen L, Lu X, Greenberger JS, Zhang L, Yu J. PMID: 34613772; PMCID: PMC8494436.
      View in: PubMed   Mentions: 10     Fields:    
    10. BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade. Oncogene. 2021 12; 40(48):6566-6578. Tong J, Tan X, Risnik D, Gao M, Song X, Ermine K, Shen L, Wang S, Yu J, Zhang L. PMID: 34615996; PMCID: PMC8642302.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis. Oncogene. 2021 03; 40(11):2035-2050. Fletcher R, Tong J, Risnik D, Leibowitz BJ, Wang YJ, Concha-Benavente F, DeLiberty JM, Stolz DB, Pai RK, Ferris RL, Schoen RE, Yu J, Zhang L. PMID: 33603166; PMCID: PMC7981263.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. J Cell Physiol. 2021 09; 236(9):6666-6677. Kalimuthu K, Kim JH, Park YS, Luo X, Zhang L, Ku JL, Choudry MHA, Lee YJ. PMID: 33586156.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. A novel immunochemotherapy based on targeting of cyclooxygenase and induction of immunogenic cell death. Biomaterials. 2021 03; 270:120708. Huang H, Huang Y, Chen Y, Luo Z, Zhang Z, Sun R, Wan Z, Sun J, Lu B, Zhang L, Hu J, Li S. PMID: 33578254; PMCID: PMC7910750.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis. Elife. 2020 11 02; 9. Ruan H, Li X, Xu X, Leibowitz BJ, Tong J, Chen L, Ao L, Xing W, Luo J, Yu Y, Schoen RE, Sonenberg N, Lu X, Zhang L, Yu J. PMID: 33135632; PMCID: PMC7665890.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside. Biochim Biophys Acta Rev Cancer. 2020 12; 1874(2):188447. Lizardo DY, Kuang C, Hao S, Yu J, Huang Y, Zhang L. PMID: 33035640; PMCID: PMC7886024.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    16. Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer. Theranostics. 2020; 10(18):8098-8110. Song X, Shen L, Tong J, Kuang C, Zeng S, Schoen RE, Yu J, Pei H, Zhang L. PMID: 32724460; PMCID: PMC7381732.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    17. Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis. Nat Commun. 2020 04 20; 11(1):1899. Xu J, Ma H, Ma H, Jiang W, Mela CA, Duan M, Zhao S, Gao C, Hahm ER, Lardo SM, Troy K, Sun M, Pai R, Stolz DB, Zhang L, Singh S, Brand RE, Hartman DJ, Hu J, Hainer SJ, Liu Y. PMID: 32313005; PMCID: PMC7171144.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    18. Immunogenic cell death in colon cancer prevention and therapy. Mol Carcinog. 2020 07; 59(7):783-793. Ruan H, Leibowitz BJ, Zhang L, Yu J. PMID: 32215970; PMCID: PMC7593824.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    19. Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer. Theranostics. 2020; 10(1):265-280. Deng X, Li S, Kong F, Ruan H, Xu X, Zhang X, Wu Z, Zhang L, Xu Y, Yuan H, Peng H, Yang D, Guan M. PMID: 31903119; PMCID: PMC6929633.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    20. High Loading of Hydrophobic and Hydrophilic Agents via Small Immunostimulatory Carrier for Enhanced Tumor Penetration and Combinational Therapy. Theranostics. 2020; 10(3):1136-1150. Sun J, Chen Y, Xu J, Song X, Wan Z, Du Y, Ma W, Li X, Zhang L, Li S. PMID: 31938056; PMCID: PMC6956803.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019 05; 69(5):2164-2179. Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L. PMID: 30552702; PMCID: PMC6461480.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    22. BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5. Cancer Res. 2019 03 15; 79(6):1191-1203. Tan X, Tong J, Wang YJ, Fletcher R, Schoen RE, Yu J, Shen L, Zhang L. PMID: 30674532; PMCID: PMC6420862.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    23. Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. Cancer Res. 2018 08 15; 78(16):4704-4715. Tong J, Zheng X, Tan X, Fletcher R, Nikolovska-Coleska Z, Yu J, Zhang L. PMID: 29895675; PMCID: PMC6298746.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    24. Immunogenic effects of chemotherapy-induced tumor cell death. Genes Dis. 2018 Sep; 5(3):194-203. Wang YJ, Fletcher R, Yu J, Zhang L. PMID: 30320184; PMCID: PMC6176216.
      View in: PubMed   Mentions: 137  
    25. Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene. 2018 08; 37(33):4599-4610. Knickelbein K, Tong J, Chen D, Wang YJ, Misale S, Bardelli A, Yu J, Zhang L. PMID: 29755130; PMCID: PMC6195818.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    26. PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3930-3935. Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L. PMID: 29581256; PMCID: PMC5899441.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    27. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018 02 07; 10(427). Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. PMID: 29437148; PMCID: PMC5827930.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    28. The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice. Sci Rep. 2018 02 01; 8(1):2072. Wei L, Leibowitz BJ, Epperly M, Bi C, Li A, Steinman J, Wipf P, Li S, Zhang L, Greenberger J, Yu J. PMID: 29391546; PMCID: PMC5794877.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    29. Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta Rev Cancer. 2018 Apr; 1869(2):138-148. Fletcher R, Wang YJ, Schoen RE, Finn OJ, Yu J, Zhang L. PMID: 29391185; PMCID: PMC5955808.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    30. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017 08 15; 20(7):1692-1704. Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, Zhong M, Yuan H, Zhang L, Billiar TR, Lotze MT, Zeh HJ, Kang R, Kroemer G, Tang D. PMID: 28813679.
      View in: PubMed   Mentions: 392     Fields:    Translation:HumansAnimalsCells
    31. FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. Mol Cancer Ther. 2017 09; 16(9):1979-1988. Tong J, Tan S, Nikolovska-Coleska Z, Yu J, Zou F, Zhang L. PMID: 28619760; PMCID: PMC5587378.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    32. Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 05 01; 77(9):2512-2521. Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L. PMID: 28202514; PMCID: PMC5626525.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    33. Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. Oncotarget. 2017 Feb 07; 8(6):9280-9292. Li X, Li M, Ruan H, Qiu W, Xu X, Zhang L, Yu J. PMID: 28030835; PMCID: PMC5354731.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    34. 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers. J Immunother Cancer. 2016; 4:65. Van Der Kraak L, Goel G, Ramanan K, Kaltenmeier C, Zhang L, Normolle DP, Freeman GJ, Tang D, Nason KS, Davison JM, Luketich JD, Dhupar R, Lotze MT. PMID: 27777774; PMCID: PMC5067917.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    35. Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. J Clin Invest. 2016 11 01; 126(11):4076-4087. Wei L, Leibowitz BJ, Wang X, Epperly M, Greenberger J, Zhang L, Yu J. PMID: 27701148; PMCID: PMC5096907.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCellsPHPublic Health
    36. BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. Oncotarget. 2016 Jul 26; 7(30):47699-47710. He K, Chen D, Ruan H, Li X, Tong J, Xu X, Zhang L, Yu J. PMID: 27351224; PMCID: PMC5216972.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    37. FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. Oncogene. 2017 02 09; 36(6):787-796. Tong J, Tan S, Zou F, Yu J, Zhang L. PMID: 27399335; PMCID: PMC5226932.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    38. Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta. 2016 Apr; 1865(2):228-36. Chen D, Yu J, Zhang L. PMID: 26968619; PMCID: PMC4860077.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    39. Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. Nat Commun. 2015 Sep 22; 6:8305. Misale S, Bozic I, Tong J, Peraza-Penton A, Lallo A, Baldi F, Lin KH, Truini M, Trusolino L, Bertotti A, Di Nicolantonio F, Nowak MA, Zhang L, Wood KC, Bardelli A. PMID: 26392303; PMCID: PMC4595628.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    40. Amphiphilic sugar poly(orthoesters) as pH-responsive nanoscopic assemblies for acidity-enhanced drug delivery and cell killing. Chem Commun (Camb). 2015 Aug 25; 51(66):13078-81. Li L, Knickelbein K, Zhang L, Wang J, Obrinske M, Ma GZ, Zhang LM, Bitterman L, Du W. PMID: 26096366.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    41. Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 2015 Jun 20; 6(17):15022-34. Chen X, Song X, Yue W, Chen D, Yu J, Yao Z, Zhang L. PMID: 25909283; PMCID: PMC4558133.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    42. Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. Cell Death Dis. 2015 Apr 23; 6:e1729. Brown MF, Leibowitz BJ, Chen D, He K, Zou F, Sobol RW, Beer-Stolz D, Zhang L, Yu J. PMID: 25906152; PMCID: PMC4650537.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    43. mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation. Oncogene. 2016 Jan 14; 35(2):148-57. He K, Zheng X, Li M, Zhang L, Yu J. PMID: 25867072; PMCID: PMC4603992.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    44. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10; 5:8566. Wang X, Wei L, Cramer JM, Leibowitz BJ, Judge C, Epperly M, Greenberger J, Wang F, Li L, Stelzner MG, Dunn JCY, Martin MG, Lagasse E, Zhang L, Yu J. PMID: 25858503; PMCID: PMC4392360.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    45. Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer. Genes Dis. 2015 Mar; 2(1):4-12. Knickelbein K, Zhang L. PMID: 25815366; PMCID: PMC4372129.
      View in: PubMed   Mentions: 52  
    46. BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16520-5. Leibowitz B, Qiu W, Buchanan ME, Zou F, Vernon P, Moyer MP, Yin XM, Schoen RE, Yu J, Zhang L. PMID: 25368155; PMCID: PMC4246283.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    47. Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer. Cell Death Dis. 2014 Oct 30; 5:e1504. Song X, Kim SY, Zhang L, Tang D, Bartlett DL, Kwon YT, Lee YJ. PMID: 25356873; PMCID: PMC4649537.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    48. Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies. Chem Commun (Camb). 2014 Oct 28; 50(84):12742-5. Fu L, Li L, Wang J, Knickelbein K, Zhang L, Milligan I, Xu Y, O'Hara K, Bitterman L, Du W. PMID: 25204678.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    49. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014 Sep 30; 5(18):8107-22. Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, Zhang L. PMID: 25237903; PMCID: PMC4226670.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    50. Receptor interactive protein kinase 3 promotes Cisplatin-triggered necrosis in apoptosis-resistant esophageal squamous cell carcinoma cells. PLoS One. 2014; 9(6):e100127. Xu Y, Lin Z, Zhao N, Zhou L, Liu F, Cichacz Z, Zhang L, Zhan Q, Zhao X. PMID: 24959694; PMCID: PMC4069059.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    51. Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis. Clin Cancer Res. 2014 Jul 01; 20(13):3472-84. Chen D, Wei L, Yu J, Zhang L. PMID: 24763611; PMCID: PMC4079733.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    52. Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice. Nat Commun. 2014 Mar 18; 5:3494. Leibowitz BJ, Wei L, Zhang L, Ping X, Epperly M, Greenberger J, Cheng T, Yu J. PMID: 24637717; PMCID: PMC4327858.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    53. Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells. Mol Cancer Ther. 2014 May; 13(5):1298-308. Sun J, Knickelbein K, He K, Chen D, Dudgeon C, Shu Y, Yu J, Zhang L. PMID: 24563542; PMCID: PMC4013266.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    54. Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death. Biochem Pharmacol. 2014 Mar 15; 88(2):178-88. Kim SY, Song X, Zhang L, Bartlett DL, Lee YJ. PMID: 24486574; PMCID: PMC3969586.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    55. Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion. Carcinogenesis. 2014 Aug; 35(8):1707-16. Chen X, Meng J, Yue W, Yu J, Yang J, Yao Z, Zhang L. PMID: 24480807; PMCID: PMC4123641.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    56. Role of apoptosis in colon cancer biology, therapy, and prevention. Curr Colorectal Cancer Rep. 2013 Dec; 9(4). Zhang L, Yu J. PMID: 24273467; PMCID: PMC3836193.
      View in: PubMed   Mentions: 52  
    57. Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax. Mol Cancer Ther. 2013 Nov; 12(11):2559-68. He K, Zheng X, Zhang L, Yu J. PMID: 23966620; PMCID: PMC3823684.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    58. ADAR1 is essential for intestinal homeostasis and stem cell maintenance. Cell Death Dis. 2013 Apr 18; 4:e599. Qiu W, Wang X, Buchanan M, He K, Sharma R, Zhang L, Wang Q, Yu J. PMID: 23598411; PMCID: PMC3641348.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    59. PEG-farnesylthiosalicylate conjugate as a nanomicellar carrier for delivery of paclitaxel. Bioconjug Chem. 2013 Mar 20; 24(3):464-72. Zhang X, Lu J, Huang Y, Zhao W, Chen Y, Li J, Gao X, Venkataramanan R, Sun M, Stolz DB, Zhang L, Li S. PMID: 23425093; PMCID: PMC3623935.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    60. Crizotinib induces PUMA-dependent apoptosis in colon cancer cells. Mol Cancer Ther. 2013 May; 12(5):777-86. Zheng X, He K, Zhang L, Yu J. PMID: 23427294; PMCID: PMC3651803.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    61. Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. Cell Death Differ. 2013 May; 20(5):744-54. Peng R, Tong JS, Li H, Yue B, Zou F, Yu J, Zhang L. PMID: 23392123; PMCID: PMC3619242.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    62. The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA. PLoS One. 2012; 7(8):e43158. Sun J, Sun Q, Brown MF, Dudgeon C, Chandler J, Xu X, Shu Y, Zhang L, Yu J. PMID: 22912816; PMCID: PMC3422222.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
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    138. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell. 1995 Jul 28; 82(2):309-19. Baker SM, Bronner CE, Zhang L, Plug AW, Robatzek M, Warren G, Elliott EA, Yu J, Ashley T, Arnheim N, Flavell RA, Liskay RM. PMID: 7628019.
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    139. CAG repeat length variation in sperm from a patient with Kennedy's disease. Hum Mol Genet. 1995 Feb; 4(2):303-5. Zhang L, Fischbeck KH, Arnheim N. PMID: 7757084.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    140. Studying human mutations by sperm typing: instability of CAG trinucleotide repeats in the human androgen receptor gene. Nat Genet. 1994 Aug; 7(4):531-5. Zhang L, Leeflang EP, Yu J, Arnheim N. PMID: 7951325.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    141. A new source of polymorphic DNA markers for sperm typing: analysis of microsatellite repeats in single cells. Am J Hum Genet. 1992 Nov; 51(5):985-91. Hubert R, Weber JL, Schmitt K, Zhang L, Arnheim N. PMID: 1415267; PMCID: PMC1682826.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    142. Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5847-51. Zhang L, Cui X, Schmitt K, Hubert R, Navidi W, Arnheim N. PMID: 1631067; PMCID: PMC49394.
      View in: PubMed   Mentions: 250     Fields:    Translation:HumansCells
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