Jobin Varkey, PhD

Title(s)Assistant Professor of Research Physiology and Neuroscience
Phone+1 323 442 0106
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    Collapse Biography 
    Collapse Education and Training
    University of Southern California, Los Angeles. USAPostdoctoral training07/2013Biochemistry/Molecular biology
    Centre for Cellular and Molecular Biology, Hyderabad, IndiaPhD05/2008Biochemistry/Life Sciences
    University of Allahabad, Allahabad, IndiaMS01/2002Biotechnology
    University of Rajasthan, Jaipur, IndiaBS05/1999Biotechnology
    Collapse Awards and Honors
    Department of Biotechnology, Government of India2013  - 2016DBT Ramalingaswami Fellowship
    Council of Scientific and Industrial Research, Government of India2004  - 2007Senior Research Fellowship
    Council of Scientific and Industrial Research, Government of India2002  - 2004Junior Research Fellowship
    Department of Biotechnology, Government of India1999  - 2001MS Scholarship

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rovere M, Powers AE, Jiang H, Pitino JC, Fonseca-Ornelas L, Patel DS, Achille A, Langen R, Varkey J, Bartels T. E46K-like a-synuclein mutants increase lipid interactions and disrupt membrane selectivity. J Biol Chem. 2019 Jun 21; 294(25):9799-9812. PMID: 31048377.
      View in: PubMed
    2. George G, Valiya Parambath S, Lokappa SB, Varkey J. Construction of Parkinson's disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes. Gene. 2019 May 20; 697:67-77. PMID: 30776463.
      View in: PubMed
    3. George G, Singh S, Lokappa SB, Varkey J. Gene co-expression network analysis for identifying genetic markers in Parkinson's disease - a three-way comparative approach. Genomics. 2018 May 28. PMID: 29852216.
      View in: PubMed
    4. Rawat A, Langen R, Varkey J. Membranes as modulators of amyloid protein misfolding and target of toxicity. Biochim Biophys Acta Biomembr. 2018 Apr 25. PMID: 29702073.
      View in: PubMed
    5. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 Mar; 24(3):326-337. PMID: 29400711.
      View in: PubMed
    6. Varkey J, Langen R. Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. J Magn Reson. 2017 Jul; 280:127-139. PMID: 28579098.
      View in: PubMed
    7. Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. a-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. J Biol Chem. 2016 Jan 29; 291(5):2310-8. PMID: 26644467; PMCID: PMC4732214 [Available on 01/29/17].
    8. Basak S, Prasad GV, Varkey J, Chattopadhyay K. Early sodium dodecyl sulfate induced collapse of a-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46. PMID: 25369246.
      View in: PubMed
    9. Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. Nonaggregated a-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 2014 Jun 24; 53(24):3889-96. PMID: 24884175; PMCID: PMC4075992.
    10. Cheng CY, Varkey J, Ambroso MR, Langen R, Han S. Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43. PMID: 24082088.
      View in: PubMed
    11. Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R. a-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. J Biol Chem. 2013 Jun 14; 288(24):17620-30. PMID: 23609437; PMCID: PMC3682563.
    12. Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):19965-70. PMID: 23161913.
      View in: PubMed
    13. Mizuno N, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R, Steven AC. Remodeling of lipid vesicles into cylindrical micelles by a-synuclein in an extended a-helical conformation. J Biol Chem. 2012 Aug 24; 287(35):29301-11. PMID: 22767608.
      View in: PubMed
    14. Meier F, Abeywardana T, Dhall A, Marotta NP, Varkey J, Langen R, Chatterjee C, Pratt MR. Semisynthetic, site-specific ubiquitin modification of a-synuclein reveals differential effects on aggregation. J Am Chem Soc. 2012 Mar 28; 134(12):5468-71. PMID: 22404520.
      View in: PubMed
    15. Varkey J, Isas JM, Mizuno N, Jensen MB, Bhatia VK, Jao CC, Petrlova J, Voss JC, Stamou DG, Steven AC, Langen R. Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. J Biol Chem. 2010 Oct 15; 285(42):32486-93. PMID: 20693280; PMCID: PMC2952250.
    16. Varkey J, Singh S, Nagaraj R. Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides. 2006 Nov; 27(11):2614-23. PMID: 16914230.
      View in: PubMed
    17. Varkey J, Nagaraj R. Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines. Antimicrob Agents Chemother. 2005 Nov; 49(11):4561-6. PMID: 16251296; PMCID: PMC1280114.