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TDP43 and Huntingtin Exon-1 Undergo A Conformationally Specific Interaction That Strongly Alters the Fibril Formation of Both Proteins. J Biol Chem. 2024 Aug 09; 107660.
George G, Ajayan A, Varkey J, Pandey NK, Chen J, Langen R. PMID: 39128727.
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HumansCells
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Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1. J Biol Chem. 2024 Jan; 300(1):105585.
Pandey NK, Varkey J, Ajayan A, George G, Chen J, Langen R. PMID: 38141760; PMCID: PMC10825056.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Amplification of neurotoxic HTTex1 assemblies in human neurons. Neurobiol Dis. 2021 11; 159:105517.
Chongtham A, Isas JM, Pandey NK, Rawat A, Yoo JH, Mastro T, Kennedy MB, Langen R, Khoshnan A. PMID: 34563643; PMCID: PMC8943833.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted. Nat Commun. 2021 07 13; 12(1):4272.
Mario Isas J, Pandey NK, Xu H, Teranishi K, Okada AK, Fultz EK, Rawat A, Applebaum A, Meier F, Chen J, Langen R, Siemer AB. PMID: 34257293; PMCID: PMC8277859.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells. ACS Chem Neurosci. 2020 08 05; 11(15):2286-2295.
Lo CH, Pandey NK, Lim CK, Ding Z, Tao M, Thomas DD, Langen R, Sachs JN. PMID: 32568514.
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11 Fields:
Translation:
HumansCells
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Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms. Structure. 2019 10 01; 27(10):1570-1580.e4.
Tao M, Pandey NK, Barnes R, Han S, Langen R. PMID: 31466833; PMCID: PMC6774876.
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18 Fields:
Translation:
HumansCells
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Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL. Biochim Biophys Acta Proteins Proteom. 2019 Jul - Aug; 1867(7-8):691-700.
Vasquez-Montes V, Vargas-Uribe M, Pandey NK, Rodnin MV, Langen R, Ladokhin AS. PMID: 31004798; PMCID: PMC6589348.
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13 Fields:
Translation:
HumansCells
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The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract. J Biol Chem. 2018 12 21; 293(51):19613-19623.
Bravo-Arredondo JM, Kegulian NC, Schmidt T, Pandey NK, Situ AJ, Ulmer TS, Langen R. PMID: 30315108; PMCID: PMC6314148.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Hum Mol Genet. 2018 07 01; 27(13):2330-2343.
Ko J, Isas JM, Sabbaugh A, Yoo JH, Pandey NK, Chongtham A, Ladinsky M, Wu WL, Rohweder H, Weiss A, Macdonald D, Munoz-Sanjuan I, Langen R, Patterson PH, Khoshnan A. PMID: 29912367; PMCID: PMC6005051.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms. J Biol Chem. 2018 02 16; 293(7):2597-2605.
Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R. PMID: 29282287; PMCID: PMC5818184.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils. Biochemistry. 2017 07 18; 56(28):3579-3586.
Isas JM, Langen A, Isas MC, Pandey NK, Siemer AB. PMID: 28621522; PMCID: PMC5575822.
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19 Fields:
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Humans
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Effects of urea, metal ions and surfactants on the binding of baicalein with bovine serum albumin. J Pharm Anal. 2016 Aug; 6(4):256-267.
Roy AS, Dinda AK, Pandey NK, Dasgupta S. PMID: 29403991; PMCID: PMC5762607.
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PubMed Mentions:
5
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Evidence of two oxidation states of copper during aggregation of hen egg white lysozyme (HEWL). Int J Biol Macromol. 2015 May; 76:1-9.
Ghosh S, Pandey NK, Bhattacharya S, Roy A, Nagy NV, Dasgupta S. PMID: 25709020.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Effect of temperature and solvent on fibrillation of human serum albumin. Protein Pept Lett. 2015; 22(2):112-8.
Pandey NK, Ghosh S, Tripathy DR, Dasgupta S. PMID: 24654852.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Effect of (-)-epigallocatechin gallate on the fibrillation of human serum albumin. Int J Biol Macromol. 2014 Sep; 70:312-9.
Bhattacharya S, Pandey NK, Roy A, Dasgupta S. PMID: 25017180.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Disruption of human serum albumin fibrils by a static electric field. Journal of Physics D: Applied Physics. 2014; 47:305401.
Nitin K Pandey, Subhadeep Mitra, Monojit Chakraborty, Sudeshna Ghosh, Shubhatam Sen, Swagata Dasgupta, Sunando DasGupta.
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Copper(II) directs formation of toxic amorphous aggregates resulting in inhibition of hen egg white lysozyme fibrillation under alkaline salt-mediated conditions. J Biomol Struct Dyn. 2015; 33(5):991-1007.
Ghosh S, Pandey NK, Banerjee P, Chaudhury K, Nagy NV, Dasgupta S. PMID: 24806136.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Crowded milieu prevents fibrillation of hen egg white lysozyme with retention of enzymatic activity. J Photochem Photobiol B. 2014 Sep 05; 138:8-16.
Ghosh S, Pandey NK, Dasgupta S. PMID: 24892979.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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An insight into the ribonucleolytic and antiangiogenic activity of buffalo lactoferrin. J Biomol Struct Dyn. 2015; 33(1):184-95.
Tripathy DR, Pandey NK, Dinda AK, Ghosh S, Singha Roy A, Dasgupta S. PMID: 24320703.
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AnimalsCells
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Distribution of protein Ramachandran psi (ψ) angle using non-resonance visible raman scattering measurements. J Phys Chem B. 2013 Nov 14; 117(45):13993-4000.
Bhattacharya S, Ghosh S, Pandey NK, Chaudhury S, Dasgupta S, Roy A. PMID: 24134469.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Prolonged glycation of hen egg white lysozyme generates non amyloidal structures. PLoS One. 2013; 8(9):e74336.
Ghosh S, Pandey NK, Singha Roy A, Tripathy DR, Dinda AK, Dasgupta S. PMID: 24066139; PMCID: PMC3774808.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Fructose restrains fibrillogenesis in human serum albumin. Int J Biol Macromol. 2013 Oct; 61:424-32.
Pandey NK, Ghosh S, Dasgupta S. PMID: 23954680.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Fibrillation of human serum albumin shows nonspecific coordination on stoichiometric increment of Copper(II). J Biomol Struct Dyn. 2014; 32(9):1366-78.
Pandey NK, Ghosh S, Nagy NV, Dasgupta S. PMID: 23869596.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Binding of hen egg white lysozyme fibrils with nucleic acids. J Photochem Photobiol B. 2013 Oct 05; 127:52-60.
Ghosh S, Pandey NK, Sen S, Tripathy DR, Dasgupta S. PMID: 23933246.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Effect of surfactants on preformed fibrils of human serum albumin. Int J Biol Macromol. 2013 Aug; 59:39-45.
Pandey NK, Ghosh S, Dasgupta S. PMID: 23597713.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Preferential binding of fisetin to the native state of bovine serum albumin: spectroscopic and docking studies. Mol Biol Rep. 2013 Apr; 40(4):3239-53.
Singha Roy A, Pandey NK, Dasgupta S. PMID: 23277393.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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(-)-Epicatechin gallate prevents alkali-salt mediated fibrillogenesis of hen egg white lysozyme. Int J Biol Macromol. 2013 Mar; 54:90-8.
Ghosh S, Pandey NK, Dasgupta S. PMID: 23219698.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Fibrillation of hen egg white lysozyme triggers reduction of copper(II). Int J Biol Macromol. 2012 Jul-Aug; 51(1-2):1-6.
Ghosh S, Pandey NK, Bhattacharya S, Roy A, Dasgupta S. PMID: 22561370.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Fibrillation in human serum albumin is enhanced in the presence of copper(II). J Phys Chem B. 2010 Aug 12; 114(31):10228-33.
Pandey NK, Ghosh S, Dasgupta S. PMID: 20684647.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells