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TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins. J Biol Chem. 2024 Sep; 300(9):107660.
George G, Ajayan A, Varkey J, Pandey NK, Chen J, Langen R. PMID: 39128727; PMCID: PMC11408864.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1. J Biol Chem. 2024 01; 300(1):105585.
Pandey NK, Varkey J, Ajayan A, George G, Chen J, Langen R. PMID: 38141760; PMCID: PMC10825056.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Amplification of neurotoxic HTTex1 assemblies in human neurons. Neurobiol Dis. 2021 11; 159:105517.
Chongtham A, Isas JM, Pandey NK, Rawat A, Yoo JH, Mastro T, Kennedy MB, Langen R, Khoshnan A. PMID: 34563643; PMCID: PMC8943833.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted. Nat Commun. 2021 07 13; 12(1):4272.
Mario Isas J, Pandey NK, Xu H, Teranishi K, Okada AK, Fultz EK, Rawat A, Applebaum A, Meier F, Chen J, Langen R, Siemer AB. PMID: 34257293; PMCID: PMC8277859.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells. ACS Chem Neurosci. 2020 08 05; 11(15):2286-2295.
Lo CH, Pandey NK, Lim CK, Ding Z, Tao M, Thomas DD, Langen R, Sachs JN. PMID: 32568514.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms. Structure. 2019 10 01; 27(10):1570-1580.e4.
Tao M, Pandey NK, Barnes R, Han S, Langen R. PMID: 31466833; PMCID: PMC6774876.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL. Biochim Biophys Acta Proteins Proteom. 2019 Jul - Aug; 1867(7-8):691-700.
Vasquez-Montes V, Vargas-Uribe M, Pandey NK, Rodnin MV, Langen R, Ladokhin AS. PMID: 31004798; PMCID: PMC6589348.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract. J Biol Chem. 2018 12 21; 293(51):19613-19623.
Bravo-Arredondo JM, Kegulian NC, Schmidt T, Pandey NK, Situ AJ, Ulmer TS, Langen R. PMID: 30315108; PMCID: PMC6314148.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Hum Mol Genet. 2018 07 01; 27(13):2330-2343.
Ko J, Isas JM, Sabbaugh A, Yoo JH, Pandey NK, Chongtham A, Ladinsky M, Wu WL, Rohweder H, Weiss A, Macdonald D, Munoz-Sanjuan I, Langen R, Patterson PH, Khoshnan A. PMID: 29912367; PMCID: PMC6005051.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms. J Biol Chem. 2018 02 16; 293(7):2597-2605.
Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R. PMID: 29282287; PMCID: PMC5818184.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils. Biochemistry. 2017 07 18; 56(28):3579-3586.
Isas JM, Langen A, Isas MC, Pandey NK, Siemer AB. PMID: 28621522; PMCID: PMC5575822.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017 Sep 02; 390(10098):946-958.
Shi T, McAllister DA, O'Brien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, Balsells E, Acacio S, Aguayo C, Alassani I, Ali A, Antonio M, Awasthi S, Awori JO, Azziz-Baumgartner E, Baggett HC, Baillie VL, Balmaseda A, Barahona A, Basnet S, Bassat Q, Basualdo W, Bigogo G, Bont L, Breiman RF, Brooks WA, Broor S, Bruce N, Bruden D, Buchy P, Campbell S, Carosone-Link P, Chadha M, Chipeta J, Chou M, Clara W, Cohen C, de Cuellar E, Dang DA, Dash-Yandag B, Deloria-Knoll M, Dherani M, Eap T, Ebruke BE, Echavarria M, de Freitas Lázaro Emediato CC, Fasce RA, Feikin DR, Feng L, Gentile A, Gordon A, Goswami D, Goyet S, Groome M, Halasa N, Hirve S, Homaira N, Howie SRC, Jara J, Jroundi I, Kartasasmita CB, Khuri-Bulos N, Kotloff KL, Krishnan A, Libster R, Lopez O, Lucero MG, Lucion F, Lupisan SP, Marcone DN, McCracken JP, Mejia M, Moisi JC, Montgomery JM, Moore DP, Moraleda C, Moyes J, Munywoki P, Mutyara K, Nicol MP, Nokes DJ, Nymadawa P, da Costa Oliveira MT, Oshitani H, Pandey N, Paranhos-Baccalà G, Phillips LN, Picot VS, Rahman M, Rakoto-Andrianarivelo M, Rasmussen ZA, Rath BA, Robinson A, Romero C, Russomando G, Salimi V, Sawatwong P, Scheltema N, Schweiger B, Scott JAG, Seidenberg P, Shen K, Singleton R, Sotomayor V, Strand TA, Sutanto A, Sylla M, Tapia MD, Thamthitiwat S, Thomas ED, Tokarz R, Turner C, Venter M, Waicharoen S, Wang J, Watthanaworawit W, Yoshida LM, Yu H, Zar HJ, Campbell H, Nair H, RSV Global Epidemiology Network. PMID: 28689664; PMCID: PMC5592248.
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PubMed Mentions:
1222 Fields:
Translation:
HumansCells
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Effects of urea, metal ions and surfactants on the binding of baicalein with bovine serum albumin. J Pharm Anal. 2016 Aug; 6(4):256-267.
Roy AS, Dinda AK, Pandey NK, Dasgupta S. PMID: 29403991; PMCID: PMC5762607.
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PubMed Mentions:
5
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Bisphenol A reduces fertilizing ability and motility by compromising mitochondrial function of sperm. Environ Toxicol Chem. 2015 Jul; 34(7):1617-22.
Singh RP, Shafeeque CM, Sharma SK, Pandey NK, Singh R, Mohan J, Kolluri G, Saxena M, Sharma B, Sastry KV, Kataria JM, Azeez PA. PMID: 25728985.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Evidence of two oxidation states of copper during aggregation of hen egg white lysozyme (HEWL). Int J Biol Macromol. 2015 May; 76:1-9.
Ghosh S, Pandey NK, Bhattacharya S, Roy A, Nagy NV, Dasgupta S. PMID: 25709020.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Effect of temperature and solvent on fibrillation of human serum albumin. Protein Pept Lett. 2015; 22(2):112-8.
Pandey NK, Ghosh S, Tripathy DR, Dasgupta S. PMID: 24654852.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Effect of (-)-epigallocatechin gallate on the fibrillation of human serum albumin. Int J Biol Macromol. 2014 Sep; 70:312-9.
Bhattacharya S, Pandey NK, Roy A, Dasgupta S. PMID: 25017180.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Disruption of human serum albumin fibrils by a static electric field. Journal of Physics D: Applied Physics. 2014; 47:305401.
Nitin K Pandey, Subhadeep Mitra, Monojit Chakraborty, Sudeshna Ghosh, Shubhatam Sen, Swagata Dasgupta, Sunando DasGupta.
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Copper(II) directs formation of toxic amorphous aggregates resulting in inhibition of hen egg white lysozyme fibrillation under alkaline salt-mediated conditions. J Biomol Struct Dyn. 2015; 33(5):991-1007.
Ghosh S, Pandey NK, Banerjee P, Chaudhury K, Nagy NV, Dasgupta S. PMID: 24806136.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Crowded milieu prevents fibrillation of hen egg white lysozyme with retention of enzymatic activity. J Photochem Photobiol B. 2014 Sep 05; 138:8-16.
Ghosh S, Pandey NK, Dasgupta S. PMID: 24892979.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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An insight into the ribonucleolytic and antiangiogenic activity of buffalo lactoferrin. J Biomol Struct Dyn. 2015; 33(1):184-95.
Tripathy DR, Pandey NK, Dinda AK, Ghosh S, Singha Roy A, Dasgupta S. PMID: 24320703.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Distribution of protein Ramachandran psi (ψ) angle using non-resonance visible raman scattering measurements. J Phys Chem B. 2013 Nov 14; 117(45):13993-4000.
Bhattacharya S, Ghosh S, Pandey NK, Chaudhury S, Dasgupta S, Roy A. PMID: 24134469.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Prolonged glycation of hen egg white lysozyme generates non amyloidal structures. PLoS One. 2013; 8(9):e74336.
Ghosh S, Pandey NK, Singha Roy A, Tripathy DR, Dinda AK, Dasgupta S. PMID: 24066139; PMCID: PMC3774808.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Fructose restrains fibrillogenesis in human serum albumin. Int J Biol Macromol. 2013 Oct; 61:424-32.
Pandey NK, Ghosh S, Dasgupta S. PMID: 23954680.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Fibrillation of human serum albumin shows nonspecific coordination on stoichiometric increment of Copper(II). J Biomol Struct Dyn. 2014; 32(9):1366-78.
Pandey NK, Ghosh S, Nagy NV, Dasgupta S. PMID: 23869596.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Binding of hen egg white lysozyme fibrils with nucleic acids. J Photochem Photobiol B. 2013 Oct 05; 127:52-60.
Ghosh S, Pandey NK, Sen S, Tripathy DR, Dasgupta S. PMID: 23933246.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Effect of surfactants on preformed fibrils of human serum albumin. Int J Biol Macromol. 2013 Aug; 59:39-45.
Pandey NK, Ghosh S, Dasgupta S. PMID: 23597713.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Preferential binding of fisetin to the native state of bovine serum albumin: spectroscopic and docking studies. Mol Biol Rep. 2013 Apr; 40(4):3239-53.
Singha Roy A, Pandey NK, Dasgupta S. PMID: 23277393.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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(-)-Epicatechin gallate prevents alkali-salt mediated fibrillogenesis of hen egg white lysozyme. Int J Biol Macromol. 2013 Mar; 54:90-8.
Ghosh S, Pandey NK, Dasgupta S. PMID: 23219698.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Fibrillation of hen egg white lysozyme triggers reduction of copper(II). Int J Biol Macromol. 2012 Jul-Aug; 51(1-2):1-6.
Ghosh S, Pandey NK, Bhattacharya S, Roy A, Dasgupta S. PMID: 22561370.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Fibrillation in human serum albumin is enhanced in the presence of copper(II). J Phys Chem B. 2010 Aug 12; 114(31):10228-33.
Pandey NK, Ghosh S, Dasgupta S. PMID: 20684647.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells