Lucio Comai, PhD

TitleProfessor of Molecular Microbiology & Immunology
InstitutionUniversity of Southern California
DepartmentMolecular Microbiology and Immunology
AddressHMR 700A 2011 Zonal Ave.
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 3950
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    Other Positions
    TitleDirector of BSL-3 Laboratory

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    Dr. Comai received his Ph.D.in Biochemistry in 1990 from the University of California, Davis and completed his postdoctoral training at University of California, Berkeley. He joined the faculty of the Keck School of Medicine in 1995 and became a member of the Institute for Genetic Medicine in 2005.

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    Identification of Therapeutic Small Molecules for Myotonic Dystrophy Type 1
    NIH/NINDS R21NS077722Sep 30, 2011 - Aug 31, 2014
    Role: Co-Principal Investigator
    Role of the Werner syndrome protein complex in the metabolism of chromosome ends
    NIH/NIA R01AG034156Apr 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    Biochemical analyses of muscleblind complexes in myotonic dystrophy
    NIH/NINDS R01NS060839Feb 1, 2007 - Nov 30, 2014
    Role: Co-Principal Investigator
    The Werner syndrome protein in CPT-induced DNA damage
    NIH/NIA R01AG023873Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    Viral regulation of ribosomal RNA transcription
    NIH/NIGMS R01GM053949Jan 1, 1998 - Aug 31, 2010
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li B, Reddy S, Comai L. The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase d Elongation. Mol Cell Biol. 2017 Feb 01; 37(3). PMID: 27849570.
      View in: PubMed
    2. Reddy S, Comai L. Recent advances in understanding the role of lamins in health and disease. F1000Res. 2016; 5:2536. PMID: 27803806.
      View in: PubMed
    3. Choi J, Dixon DM, Dansithong W, Abdallah WF, Roos KP, Jordan MC, Trac B, Lee HS, Comai L, Reddy S. Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. Sci Rep. 2016 08 03; 6:30999. PMID: 27484195.
      View in: PubMed
    4. Choi J, Personius KE, DiFranco M, Dansithong W, Yu C, Srivastava S, Dixon DM, Bhatt DB, Comai L, Vergara JL, Reddy S. Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation. EBioMedicine. 2015 Sep; 2(9):1034-47. PMID: 26501102; PMCID: PMC4588380.
    5. Dixon DM, Choi J, El-Ghazali A, Park SY, Roos KP, Jordan MC, Fishbein MC, Comai L, Reddy S. Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms. Sci Rep. 2015 Mar 12; 5:9042. PMID: 25761764; PMCID: PMC4356957.
    6. Li B, Iglesias-Pedraz JM, Chen LY, Yin F, Cadenas E, Reddy S, Comai L. Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell. 2014 Apr; 13(2):367-78. PMID: 24757718; PMCID: PMC3999508.
    7. Jog SP, Paul S, Dansithong W, Tring S, Comai L, Reddy S. RNA splicing is responsive to MBNL1 dose. PLoS One. 2012; 7(11):e48825. PMID: 23166594; PMCID: PMC3499511.
    8. Candelario J, Chen LY, Marjoram P, Reddy S, Comai L. A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 2012 Aug; 4(8):567-77. PMID: 22948034; PMCID: PMC3461344.
    9. Paul S, Dansithong W, Jog SP, Holt I, Mittal S, Brook JD, Morris GE, Comai L, Reddy S. Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011 Nov 04; 286(44):38427-38. PMID: 21900255; PMCID: PMC3207417.
    10. Reddy S, Comai L. Lamin A, farnesylation and aging. Exp Cell Res. 2012 Jan 01; 318(1):1-7. PMID: 21871450; PMCID: PMC4209918.
    11. Dansithong W, Jog SP, Paul S, Mohammadzadeh R, Tring S, Kwok Y, Fry RC, Marjoram P, Comai L, Reddy S. RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. EMBO Rep. 2011 Jul 01; 12(7):735-42. PMID: 21637295; PMCID: PMC3128970.
    12. Jog SP, Reddy S, Comai L. Cell cycle-regulated association between the Werner syndrome protein and its molecular partners. Cell Cycle. 2011 Jun 15; 10(12):2038-40. PMID: 21558813; PMCID: PMC3154421.
    13. Li B, Reddy S, Comai L. Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Aging (Albany NY). 2011 Apr; 3(4):395-406. PMID: 21512205; PMCID: PMC3117455.
    14. Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 2010 Dec 01; 185(11):6985-98. PMID: 20974981; PMCID: PMC3101474.
    15. Candelario J, Borrego S, Reddy S, Comai L. Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Exp Cell Res. 2011 Feb 01; 317(3):319-29. PMID: 20974128.
      View in: PubMed
    16. Reddy S, Li B, Comai L. Processing of human telomeres by the Werner syndrome protein. Cell Cycle. 2010 Aug 15; 9(16):3137-8. PMID: 20814240; PMCID: PMC3050012.
    17. Li B, Jog S, Candelario J, Reddy S, Comai L. Altered nuclear functions in progeroid syndromes: a paradigm for aging research. ScientificWorldJournal. 2009 Dec 16; 9:1449-62. PMID: 20024518.
      View in: PubMed
    18. Liu Y, Stanford SM, Jog SP, Fiorillo E, OrrĂº V, Comai L, Bottini N. Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry. 2009 Aug 11; 48(31):7525-32. PMID: 19586056; PMCID: PMC3113683.
    19. Li B, Reddy S, Comai L. Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity. Aging (Albany NY). 2009 Mar 17; 1(3):289-302. PMID: 20157518; PMCID: PMC2806009.
    20. Dansithong W, Wolf CM, Sarkar P, Paul S, Chiang A, Holt I, Morris GE, Branco D, Sherwood MC, Comai L, Berul CI, Reddy S. Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. PLoS One. 2008; 3(12):e3968. PMID: 19092997; PMCID: PMC2597774.
    21. Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L. Perturbation of wild-type lamin A metabolism results in a progeroid phenotype. Aging Cell. 2008 Jun; 7(3):355-67. PMID: 18363904; PMCID: PMC2527236.
    22. Li B, Jog SP, Reddy S, Comai L. WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol. 2008 Mar; 28(6):1892-904. PMID: 18212065; PMCID: PMC2268394.
    23. Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo VD. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol. 2008 Jan 14; 180(1):67-81. PMID: 18195102; PMCID: PMC2213615.
    24. Lin CH, Platt MD, Ficarro SB, Hoofnagle MH, Shabanowitz J, Comai L, Hunt DF, Owens GK. Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor. Am J Physiol Cell Physiol. 2007 May; 292(5):C1617-24. PMID: 17182730.
      View in: PubMed
    25. Lin CY, Navarro S, Reddy S, Comai L. CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction. Nucleic Acids Res. 2006; 34(17):4752-66. PMID: 16971462; PMCID: PMC1635259.
    26. Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83. PMID: 16946708; PMCID: PMC1570429.
    27. Li B, Conway N, Navarro S, Comai L, Comai L. A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis. Nucleic Acids Res. 2005; 33(21):6861-7. PMID: 16396834; PMCID: PMC1310904.
    28. Sheng Z, Liang Y, Lin CY, Comai L, Chirico WJ. Direct regulation of rRNA transcription by fibroblast growth factor 2. Mol Cell Biol. 2005 Nov; 25(21):9419-26. PMID: 16227592; PMCID: PMC1265826.
    29. Zhang C, Comai L, Johnson DL. PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. Mol Cell Biol. 2005 Aug; 25(16):6899-911. PMID: 16055704; PMCID: PMC1190253.
    30. Banerjee R, Weidman MK, Navarro S, Comai L, Dasgupta A. Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription. J Gen Virol. 2005 Aug; 86(Pt 8):2315-22. PMID: 16033979.
      View in: PubMed
    31. Dansithong W, Paul S, Comai L, Reddy S. MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. J Biol Chem. 2005 Feb 18; 280(7):5773-80. PMID: 15546872.
      View in: PubMed
    32. Comai L, Li B. The Werner syndrome protein at the crossroads of DNA repair and apoptosis. Mech Ageing Dev. 2004 Aug; 125(8):521-8. PMID: 15336909.
      View in: PubMed
    33. Li B, Navarro S, Kasahara N, Comai L. Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem. 2004 Apr 02; 279(14):13659-67. PMID: 14734561.
      View in: PubMed
    34. Comai L. Mechanism of RNA polymerase I transcription. Adv Protein Chem. 2004; 67:123-55. PMID: 14969726.
      View in: PubMed
    35. Comai L. Coimmunoprecipitation assay for the detection of kinase-substrate interactions. Methods Mol Biol. 2003; 218:277-84. PMID: 12616727.
      View in: PubMed
    36. Lin CY, Tuan J, Scalia P, Bui T, Comai L. The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Curr Biol. 2002 Dec 23; 12(24):2142-6. PMID: 12498690.
      View in: PubMed
    37. Li B, Comai L. Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Nucleic Acids Res. 2002 Sep 01; 30(17):3653-61. PMID: 12202749; PMCID: PMC137412.
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