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Differential Outcomes of Infection by Wild-Type SARS-CoV-2 and the B.1.617.2 and B.1.1.529 Variants of Concern in K18-hACE2 Transgenic Mice. Viruses. 2023 12 29; 16(1).
He Y, Henley J, Sell P, Comai L. PMID: 38257760; PMCID: PMC10820160.
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HumansAnimalsCells
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Mbnl2 loss alters novel context processing and impairs object recognition memory. iScience. 2023 May 19; 26(5):106732.
Khandelwal A, Cushman J, Choi J, Zhuravka I, Rajbhandari A, Valiulahi P, Li X, Zhou C, Comai L, Reddy S. PMID: 37216102; PMCID: PMC10193234.
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PubMed Mentions:
1
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Potent NKT cell ligands overcome SARS-CoV-2 immune evasion to mitigate viral pathogenesis in mouse models. PLoS Pathog. 2023 03; 19(3):e1011240.
Lu H, Liu Z, Deng X, Chen S, Zhou R, Zhao R, Parandaman R, Thind A, Henley J, Tian L, Yu J, Comai L, Feng P, Yuan W. PMID: 36961850; PMCID: PMC10128965.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Impedimetric Sensing: An Emerging Tool for Combating the COVID-19 Pandemic. Biosensors (Basel). 2023 Jan 30; 13(2).
Ong V, Soleimani A, Amirghasemi F, Khazaee Nejad S, Abdelmonem M, Razaviyayn M, Hosseinzadeh P, Comai L, Mousavi MPS. PMID: 36831970; PMCID: PMC9953732.
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PubMed Mentions:
2 Fields:
Translation:
HumansCellsPHPublic Health
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A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice. Front Immunol. 2022; 13:1007955.
Tian J, Dillion BJ, Henley J, Comai L, Kaufman DL. PMID: 36389819; PMCID: PMC9640739.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis. Proc Natl Acad Sci U S A. 2022 06 28; 119(26):e2122897119.
Qin C, Rao Y, Yuan H, Wang TY, Zhao J, Espinosa B, Liu Y, Zhang S, Savas AC, Liu Q, Zarinfar M, Rice S, Henley J, Comai L, Graham NA, Chen C, Zhang C, Feng P. PMID: 35700355; PMCID: PMC9245715.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Mbnl1 and Mbnl2 regulate brain structural integrity in mice. Commun Biol. 2021 11 30; 4(1):1342.
Sta Maria NS, Zhou C, Lee SJ, Valiulahi P, Li X, Choi J, Liu X, Jacobs R, Comai L, Reddy S. PMID: 34848815; PMCID: PMC8633067.
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PubMed Mentions:
3 Translation:
Animals
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WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells. BMC Mol Cell Biol. 2020 Oct 14; 21(1):71.
Iglesias-Pedraz JM, Fossatti-Jara DM, Valle-Riestra-Felice V, Cruz-Visalaya SR, Ayala Felix JA, Comai L. PMID: 33054770; PMCID: PMC7557079.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Measurements of Hydrogen Peroxide and Oxidative DNA Damage in a Cell Model of Premature Aging. Methods Mol Biol. 2020; 2144:245-257.
Iglesias-Pedraz JM, Comai L. PMID: 32410041.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation. Mol Cell Biol. 2017 02 01; 37(3).
Li B, Reddy S, Comai L. PMID: 27849570; PMCID: PMC5247617.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Recent advances in understanding the role of lamins in health and disease. F1000Res. 2016; 5:2536.
Reddy S, Comai L. PMID: 27803806; PMCID: PMC5074355.
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PubMed Mentions:
6 Fields:
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Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. Sci Rep. 2016 08 03; 6:30999.
Choi J, Dixon DM, Dansithong W, Abdallah WF, Roos KP, Jordan MC, Trac B, Lee HS, Comai L, Reddy S. PMID: 27484195; PMCID: PMC4971533.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation. EBioMedicine. 2015 Sep; 2(9):1034-47.
Choi J, Personius KE, DiFranco M, Dansithong W, Yu C, Srivastava S, Dixon DM, Bhatt DB, Comai L, Vergara JL, Reddy S. PMID: 26501102; PMCID: PMC4588380.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms. Sci Rep. 2015 Mar 12; 5:9042.
Dixon DM, Choi J, El-Ghazali A, Park SY, Roos KP, Jordan MC, Fishbein MC, Comai L, Reddy S. PMID: 25761764; PMCID: PMC4356957.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell. 2014 04; 13(2):367-78.
Li B, Iglesias-Pedraz JM, Chen LY, Yin F, Cadenas E, Reddy S, Comai L. PMID: 24757718; PMCID: PMC3999508.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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RNA splicing is responsive to MBNL1 dose. PLoS One. 2012; 7(11):e48825.
Jog SP, Paul S, Dansithong W, Tring S, Comai L, Reddy S. PMID: 23166594; PMCID: PMC3499511.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 2012 Aug; 4(8):567-77.
Candelario J, Chen LY, Marjoram P, Reddy S, Comai L. PMID: 22948034; PMCID: PMC3461344.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011 Nov 04; 286(44):38427-38438.
Paul S, Dansithong W, Jog SP, Holt I, Mittal S, Brook JD, Morris GE, Comai L, Reddy S. PMID: 21900255; PMCID: PMC3207417.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Lamin A, farnesylation and aging. Exp Cell Res. 2012 Jan 01; 318(1):1-7.
Reddy S, Comai L. PMID: 21871450; PMCID: PMC4209918.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. EMBO Rep. 2011 Jul 01; 12(7):735-42.
Dansithong W, Jog SP, Paul S, Mohammadzadeh R, Tring S, Kwok Y, Fry RC, Marjoram P, Comai L, Reddy S. PMID: 21637295; PMCID: PMC3128970.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Cell cycle-regulated association between the Werner syndrome protein and its molecular partners. Cell Cycle. 2011 Jun 15; 10(12):2038-40.
Jog SP, Reddy S, Comai L. PMID: 21558813; PMCID: PMC3154421.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Aging (Albany NY). 2011 Apr; 3(4):395-406.
Li B, Reddy S, Comai L. PMID: 21512205; PMCID: PMC3117455.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 2010 Dec 01; 185(11):6985-98.
Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. PMID: 20974981; PMCID: PMC3101474.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Exp Cell Res. 2011 Feb 01; 317(3):319-29.
Candelario J, Borrego S, Reddy S, Comai L. PMID: 20974128.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Processing of human telomeres by the Werner syndrome protein. Cell Cycle. 2010 Aug 15; 9(16):3137-8.
Reddy S, Li B, Comai L. PMID: 20814240; PMCID: PMC3050012.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Altered nuclear functions in progeroid syndromes: a paradigm for aging research. ScientificWorldJournal. 2009 Dec 16; 9:1449-62.
Li B, Jog S, Candelario J, Reddy S, Comai L. PMID: 20024518; PMCID: PMC4213125.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry. 2009 Aug 11; 48(31):7525-32.
Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N. PMID: 19586056; PMCID: PMC3113683.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity. Aging (Albany NY). 2009 Mar 17; 1(3):289-302.
Li B, Reddy S, Comai L. PMID: 20157518; PMCID: PMC2806009.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. PLoS One. 2008; 3(12):e3968.
Dansithong W, Wolf CM, Sarkar P, Paul S, Chiang A, Holt I, Morris GE, Branco D, Sherwood MC, Comai L, Berul CI, Reddy S. PMID: 19092997; PMCID: PMC2597774.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Perturbation of wild-type lamin A metabolism results in a progeroid phenotype. Aging Cell. 2008 Jun; 7(3):355-67.
Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L. PMID: 18363904; PMCID: PMC2527236.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol. 2008 Mar; 28(6):1892-904.
Li B, Jog SP, Reddy S, Comai L. PMID: 18212065; PMCID: PMC2268394.
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PubMed Mentions:
43 Fields:
Translation:
HumansCells
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Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol. 2008 Jan 14; 180(1):67-81.
Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo VD. PMID: 18195102; PMCID: PMC2213615.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimals
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Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor. Am J Physiol Cell Physiol. 2007 May; 292(5):C1617-24.
Lin CH, Platt MD, Ficarro SB, Hoofnagle MH, Shabanowitz J, Comai L, Hunt DF, Owens GK. PMID: 17182730.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction. Nucleic Acids Res. 2006; 34(17):4752-66.
Lin CY, Navarro S, Reddy S, Comai L. PMID: 16971462; PMCID: PMC1635259.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83.
Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. PMID: 16946708; PMCID: PMC1570429.
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PubMed Mentions:
90 Fields:
Translation:
HumansCells
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A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis. Nucleic Acids Res. 2005; 33(21):6861-7.
Li B, Conway N, Navarro S, Comai L, Comai L. PMID: 16396834; PMCID: PMC1310904.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Direct regulation of rRNA transcription by fibroblast growth factor 2. Mol Cell Biol. 2005 Nov; 25(21):9419-26.
Sheng Z, Liang Y, Lin CY, Comai L, Chirico WJ. PMID: 16227592; PMCID: PMC1265826.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. Mol Cell Biol. 2005 Aug; 25(16):6899-911.
Zhang C, Comai L, Johnson DL. PMID: 16055704; PMCID: PMC1190253.
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PubMed Mentions:
54 Fields:
Translation:
HumansCells
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Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription. J Gen Virol. 2005 Aug; 86(Pt 8):2315-2322.
Banerjee R, Weidman MK, Navarro S, Comai L, Dasgupta A. PMID: 16033979.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. J Biol Chem. 2005 Feb 18; 280(7):5773-80.
Dansithong W, Paul S, Comai L, Reddy S. PMID: 15546872.
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PubMed Mentions:
102 Fields:
Translation:
HumansCells
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The Werner syndrome protein at the crossroads of DNA repair and apoptosis. Mech Ageing Dev. 2004 Aug; 125(8):521-8.
Comai L, Li B. PMID: 15336909.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem. 2004 Apr 02; 279(14):13659-67.
Li B, Navarro S, Kasahara N, Comai L. PMID: 14734561.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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Mechanism of RNA polymerase I transcription. Adv Protein Chem. 2004; 67:123-55.
Comai L. PMID: 14969726.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Coimmunoprecipitation assay for the detection of kinase-substrate interactions. Methods Mol Biol. 2003; 218:277-84.
Comai L. PMID: 12616727.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Curr Biol. 2002 Dec 23; 12(24):2142-6.
Lin CY, Tuan J, Scalia P, Bui T, Comai L. PMID: 12498690.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Nucleic Acids Res. 2002 Sep 01; 30(17):3653-61.
Li B, Comai L. PMID: 12202749; PMCID: PMC137412.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. J Biol Chem. 2001 Mar 30; 276(13):9896-902.
Li B, Comai L. PMID: 11152456.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A. J Cell Biochem. 2001; 82(4):610-8.
Scalia P, Heart E, Comai L, Vigneri R, Sung CK. PMID: 11500939.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Functional interaction between Ku and the werner syndrome protein in DNA end processing. J Biol Chem. 2000 Sep 15; 275(37):28349-52.
Li B, Comai L. PMID: 10880505.
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PubMed Mentions:
82 Fields:
Translation:
Cells
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Repression of RNA polymerase I transcription by the tumor suppressor p53. Mol Cell Biol. 2000 Aug; 20(16):5930-8.
Zhai W, Comai L. PMID: 10913176; PMCID: PMC86070.
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PubMed Mentions:
131 Fields:
Translation:
HumansCells
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Inhibition of RNA polymerase I transcription in differentiated myeloid leukemia cells by inactivation of selectivity factor 1. Cell Growth Differ. 2000 Jan; 11(1):63-70.
Comai L, Song Y, Tan C, Bui T. PMID: 10672904.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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The nucleolus: a paradigm for cell proliferation and aging. Braz J Med Biol Res. 1999 Dec; 32(12):1473-8.
Comai L. PMID: 10585627.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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A kinase activity associated with simian virus 40 large T antigen phosphorylates upstream binding factor (UBF) and promotes formation of a stable initiation complex between UBF and SL1. Mol Cell Biol. 1999 Apr; 19(4):2791-802.
Zhai W, Comai L. PMID: 10082545; PMCID: PMC84072.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation. Mol Cell Biol. 1999 Apr; 19(4):2872-9.
Tuan JC, Zhai W, Comai L. PMID: 10082553; PMCID: PMC84080.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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VirE1 is a specific molecular chaperone for the exported single-stranded-DNA-binding protein VirE2 in Agrobacterium. Mol Microbiol. 1999 Mar; 31(6):1795-807.
Deng W, Chen L, Peng WT, Liang X, Sekiguchi S, Gordon MP, Comai L, Nester EW. PMID: 10209751.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Agrobacterium VirD2 protein interacts with plant host cyclophilins. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):7040-5.
Deng W, Chen L, Wood DW, Metcalfe T, Liang X, Gordon MP, Comai L, Nester EW. PMID: 9618535; PMCID: PMC22731.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9544-9.
Li HP, Zhang X, Duncan R, Comai L, Lai MM. PMID: 9275159; PMCID: PMC23214.
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PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
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SV40 large T antigen binds to the TBP-TAF(I) complex SL1 and coactivates ribosomal RNA transcription. Genes Dev. 1997 Jun 15; 11(12):1605-17.
Zhai W, Tuan JA, Comai L. PMID: 9203586.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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The rDNA transcription machinery is assembled during mitosis in active NORs and absent in inactive NORs. J Cell Biol. 1996 Apr; 133(2):235-46.
Roussel P, André C, Comai L, Hernandez-Verdun D. PMID: 8609158; PMCID: PMC2120807.
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PubMed Mentions:
102 Fields:
Translation:
HumansCells
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Protection of megabase DNA from shearing. Nucleic Acids Res. 1995 Oct 11; 23(19):3999-4000.
Kovacic RT, Comai L, Bendich AJ. PMID: 7479050; PMCID: PMC307324.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. Science. 1994 Dec 23; 266(5193):1966-72.
Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R. PMID: 7801123.
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PubMed Mentions:
67 Fields:
Translation:
HumansCells
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Assembly of transcriptionally active RNA polymerase I initiation factor SL1 from recombinant subunits. Science. 1994 Dec 23; 266(5193):2015-8.
Zomerdijk JC, Beckmann H, Comai L, Tjian R. PMID: 7801130.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1. Cell. 1992 Mar 06; 68(5):965-76.
Comai L, Tanese N, Tjian R. PMID: 1547496.
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PubMed Mentions:
167 Fields:
Translation:
HumansCells