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    Pinghui Feng, PhD

    TitleAssociate Professor of Molecular Microbiology & Immunology
    SchoolKeck School of Medicine of USC
    DepartmentMolecular Microbiology and Immunology
    AddressNTT 6428A 1441 Eastlake Avenue
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 865 0905
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      Dr. Pinghui Feng is an Associate Professor in the Department of Molecular Microbiology and Immunology at USC. At USC, he organizes the Department of Molecular Microbiology and Immunology Student/Fellow Seminar Series, serves as a PIBBS mentor and is a member of the USC Institute for Emerging Pathogens and Immune Diseases. Previous teaching positions include instructor at Harvard Medical School and assistant professor at University of Texas Southwestern Medical Center.

      Dr. Feng’s group investigates the roles of innate immune signaling pathways in infection and pathogenesis of human oncogenic gamma herpesvirus, Kaposi’s sarcoma-associated herpesvirus (KSHV). Recently, his group has uncovered that the MAVS-dependent innate immune pathway is exploited to promote viral lytic replication and to abrogate antiviral cytokine production. Given the inflammatory nature of KSHV-associated malignancies, Dr. Feng’s laboratory is also developing animal model(s) to interrogate key functions of innate immune signaling components in inflammation-driven oncogenesis. Currently, research in Dr. Feng’s laboratory is supported by grants from NCI, NIDCR and an ACS. Moreover, Dr. Feng is a faculty that actively participates teaching of graduate students and medical students, and supervises five postdoctoral fellows and one graduate student of his team. With extensive experience in research and teaching/mentoring trainees, Dr. Feng is highly qualified to serve as a mentor for graduate students and postdoctoral fellows.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zhang J, Tian M, Xia Z, Feng P. Roles of I?B kinase e in the innate immune defense and beyond. Virol Sin. 2016 Dec; 31(6):457-465. PMID: 28063014.
        View in: PubMed
      2. Zhao J, Zeng Y, Xu S, Chen J, Shen G, Yu C, Knipe D, Yuan W, Peng J, Xu W, Zhang C, Xia Z, Feng P. A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation. Cell Host Microbe. 2016 Nov 16. PMID: 27866900.
        View in: PubMed
      3. Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P. I?B Kinase e Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Rep. 2016 Jul 12; 16(2):405-18. PMID: 27346349.
        View in: PubMed
      4. Xie N, Yuan K, Zhou L, Wang K, Chen HN, Lei Y, Lan J, Pu Q, Gao W, Zhang L, Shen G, Li Q, Xiao H, Tang H, Xiang R, He M, Feng P, Nice EC, Wei Y, Zhang H, Yang J, Huang C. PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation. Autophagy. 2016 Sep; 12(9):1507-20. PMID: 27305174.
        View in: PubMed
      5. Zhu Y, Ramos da Silva S, He M, Liang Q, Lu C, Feng P, Jung JU, Gao SJ. An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS Pathog. 2016 May; 12(5):e1005648. PMID: 27187079.
        View in: PubMed
      6. Wan CJ, Liu YH, Feng P, Wang W, Zhu LQ, Liu ZP, Shi Y, Wan Q. Flexible Metal Oxide/Graphene Oxide Hybrid Neuromorphic Transistors on Flexible Conducting Graphene Substrates. Adv Mater. 2016 Jul; 28(28):5878-85. PMID: 27159546.
        View in: PubMed
      7. Zhao J, Li J, Xu S, Feng P. Emerging Roles of Protein Deamidation in Innate Immune Signaling. J Virol. 2016 May 1; 90(9):4262-8. PMID: 26889032.
        View in: PubMed
      8. Wan CJ, Liu YH, Zhu LQ, Feng P, Shi Y, Wan Q. Short-Term Synaptic Plasticity Regulation in Solution-Gated Indium-Gallium-Zinc-Oxide Electric-Double-Layer Transistors. ACS Appl Mater Interfaces. 2016 Apr 20; 8(15):9762-8. PMID: 27007748.
        View in: PubMed
      9. Zhang J, Feng H, Xu S, Feng P. Hijacking GPCRs by viral pathogens and tumor. Biochem Pharmacol. 2016 Aug 15; 114:69-81. PMID: 27060663.
        View in: PubMed
      10. Wan CJ, Zhu LQ, Liu YH, Feng P, Liu ZP, Cao HL, Xiao P, Shi Y, Wan Q. Proton-Conducting Graphene Oxide-Coupled Neuron Transistors for Brain-Inspired Cognitive Systems. Adv Mater. 2016 May; 28(18):3557-63. PMID: 26972820.
        View in: PubMed
      11. Feldman ER, Kara M, Oko LM, Grau KR, Krueger BJ, Zhang J, Feng P, van Dyk LF, Renne R, Tibbetts SA. A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency. mSphere. 2016 Apr; 1(2). PMID: 27110595.
        View in: PubMed
      12. Shao F, Yang Y, Zhu LQ, Feng P, Wan Q. Oxide-based Synaptic Transistors Gated by Sol-Gel Silica Electrolytes. ACS Appl Mater Interfaces. 2016 Feb 10; 8(5):3050-5. PMID: 26775562.
        View in: PubMed
      13. Liu N, Zhu LQ, Feng P, Wan CJ, Liu YH, Shi Y, Wan Q. Flexible Sensory Platform Based on Oxide-based Neuromorphic Transistors. Sci Rep. 2015; 5:18082. PMID: 26656113.
        View in: PubMed
      14. Seo GJ, Yang A, Tan B, Kim S, Liang Q, Choi Y, Yuan W, Feng P, Park HS, Jung JU. Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell Rep. 2015 Oct 13; 13(2):440-9. PMID: 26440888.
        View in: PubMed
      15. Zhao J, He S, Minassian A, Li J, Feng P. Recent advances on viral manipulation of NF-?B signaling pathway. Curr Opin Virol. 2015 Dec; 15:103-11. PMID: 26385424.
        View in: PubMed
      16. Liu YH, Zhu LQ, Feng P, Shi Y, Wan Q. Freestanding Artificial Synapses Based on Laterally Proton-Coupled Transistors on Chitosan Membranes. Adv Mater. 2015 Oct; 27(37):5599-604. PMID: 26426725.
        View in: PubMed
      17. Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060. PMID: 26221961.
        View in: PubMed
      18. Zhang J, Zhu L, Lu X, Feldman ER, Keyes LR, Wang Y, Fan H, Feng H, Xia Z, Sun J, Jiang T, Gao SJ, Tibbetts SA, Feng P. Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice. PLoS Pathog. 2015 Jun; 11(6):e1005001. PMID: 26107716.
        View in: PubMed
      19. Zhang J, He S, Wang Y, Brulois K, Lan K, Jung JU, Feng P. Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase. PLoS Pathog. 2015 Mar; 11(3):e1004768. PMID: 25811856.
        View in: PubMed
      20. Brulois K, Wong LY, Lee HR, Sivadas P, Ensser A, Feng P, Gao SJ, Toth Z, Jung JU. Association of Kaposi's Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression. J Virol. 2015 Jun 1; 89(11):6148-54. PMID: 25810551.
        View in: PubMed
      21. He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production. Mol Cell. 2015 Apr 2; 58(1):134-46. PMID: 25752576.
        View in: PubMed
      22. Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung JU. Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol. 2015 May 15; 89(10):5308-17. PMID: 25740994.
        View in: PubMed
      23. Xia Z, Guo M, Liu H, Jiang L, Li Q, Peng J, Li JD, Shan B, Feng P, Ma H. CBP-dependent Wnt/ß-catenin signaling is crucial in regulation of MDR1 transcription. Curr Cancer Drug Targets. 2015; 15(6):519-32. PMID: 25968898.
        View in: PubMed
      24. Brulois K, Toth Z, Wong LY, Feng P, Gao SJ, Ensser A, Jung JU. Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Ubiquitin E3 Ligases Have Stage-Specific Immune Evasion Roles during Lytic Replication. J Virol. 2014 Aug 15; 88(16):9335-49. PMID: 24899205.
        View in: PubMed
      25. Zhang J, Zhu L, Feng P. Dissecting innate immune signaling in viral evasion of cytokine production. J Vis Exp. 2014; (85). PMID: 24637875.
        View in: PubMed
      26. Lee HR, Doganay S, Chung B, Toth Z, Brulois K, Lee S, Kanketayeva Z, Feng P, Ha T, Jung JU. Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Targets Expression of Cellular IRF4 and the Myc Gene To Facilitate Lytic Replication. J Virol. 2014 Feb; 88(4):2183-94. PMID: 24335298.
        View in: PubMed
      27. Zhang LJ, Cao J, Feng P, Huang J, Lu J, Lu XY, Xia ZF. Influencing factors of the quality of life in Chinese burn patients: Investigation with adapted Chinese version of the BSHS-B. Burns. 2014 Jun; 40(4):731-6. PMID: 24280529.
        View in: PubMed
      28. He Z, Zhao J, Zhang J, Jung JU, Feng P. NF-?B Activation Coordinated by IKKß and IKK{varepsilon} Enables Latent Infection of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2014 Jan; 88(1):444-55. PMID: 24155403.
        View in: PubMed
      29. Liang Q, Chang B, Brulois KF, Castro K, Min CK, Rodgers MA, Shi M, Ge J, Feng P, Oh BH, Jung JU. Kaposi's sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation. J Virol. 2013 Nov; 87(22):12499-503. PMID: 24027317.
        View in: PubMed
      30. Wang Y, Lu X, Zhu L, Shen Y, Chengedza S, Feng H, Wang L, Jung JU, Gutkind JS, Gutkind JS, Feng P. IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis. Proc Natl Acad Sci U S A. 2013 Jul 2; 110(27):11139-44. PMID: 23771900.
        View in: PubMed
      31. Feng P, Moses A, Früh K. Evasion of adaptive and innate immune response mechanisms by ?-herpesviruses. Curr Opin Virol. 2013 Jun; 3(3):285-95. PMID: 23735334.
        View in: PubMed
      32. Deng LH, Zeng YL, Feng P, Liu YL, Wang LC, Bai Y, Tang H. Clinical characteristics of critical patients with pandemic influenza A (H1N1) virus infection in Chengdu, China. J Zhejiang Univ Sci B. 2012 Jan; 13(1):49-55. PMID: 22205620.
        View in: PubMed
      33. Dong X, He Z, Durakoglugil D, Arneson L, Shen Y, Feng P. Murine Gammaherpesvirus 68 Evades Host Cytokine Production via Replication Transactivator-Induced RelA Degradation. J Virol. 2012 Feb; 86(4):1930-41. PMID: 22130545.
        View in: PubMed
      34. Dong X, Feng P. Murine Gamma Herpesvirus 68 Hijacks MAVS and IKKß to Abrogate NF?B Activation and Antiviral Cytokine Production. PLoS Pathog. 2011 Nov; 7(11):e1002336. PMID: 22110409.
        View in: PubMed
      35. Dong X, Feng P. Dissecting host-virus interaction in lytic replication of a model herpesvirus. J Vis Exp. 2011; (56). PMID: 22006158.
        View in: PubMed
      36. Dong X, Feng H, Sun Q, Li H, Wu TT, Sun R, Tibbetts SA, Chen ZJ, Feng P. Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. PLoS Pathog. 2010; 6(7):e1001001. PMID: 20686657.
        View in: PubMed
      37. Feng H, Sun Z, Farzan MR, Feng P. Sulfotyrosines of the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promote tumorigenesis through autocrine activation. J Virol. 2010 Apr; 84(7):3351-61. PMID: 20106924.
        View in: PubMed
      38. Feng H, Dong X, Negaard A, Feng P. Kaposi's sarcoma-associated herpesvirus K7 induces viral G protein-coupled receptor degradation and reduces its tumorigenicity. PLoS Pathog. 2008; 4(9):e1000157. PMID: 18802460.
        View in: PubMed
      39. Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 2008 Jul; 10(7):776-87. PMID: 18552835.
        View in: PubMed
      40. Feng P, Liang C, Shin YC, Xiaofei E, Zhang W, Gravel R, Wu TT, Sun R, Usherwood E, Jung JU. A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein. PLoS Pathog. 2007 Dec; 3(12):e174. PMID: 18069888.
        View in: PubMed
      41. Liang C, Feng P, Ku B, Oh BH, Jung JU. UVRAG: a new player in autophagy and tumor cell growth. Autophagy. 2007 Jan-Feb; 3(1):69-71. PMID: 17106237.
        View in: PubMed
      42. Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol. 2006 Jul; 8(7):688-99. PMID: 16799551.
        View in: PubMed
      43. Shin YC, Nakamura H, Liang X, Feng P, Chang H, Kowalik TF, Jung JU. Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. J Virol. 2006 Mar; 80(5):2257-66. PMID: 16474133.
        View in: PubMed
      44. Lee BS, Lee SH, Feng P, Chang H, Cho NH, Jung JU. Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome. J Virol. 2005 Oct; 79(19):12173-84. PMID: 16160144.
        View in: PubMed
      45. Feng P, Everly DN, Read GS. mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. J Virol. 2005 Aug; 79(15):9651-64. PMID: 16014927.
        View in: PubMed
      46. Cho NH, Feng P, Lee SH, Lee BS, Liang X, Chang H, Jung JU. Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri. J Exp Med. 2004 Sep 6; 200(5):681-7. PMID: 15337788.
        View in: PubMed
      47. Lee SH, Chung YH, Cho NH, Gwack Y, Feng P, Jung JU. Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein. Mol Cell Biol. 2004 Jun; 24(12):5369-82. PMID: 15169900.
        View in: PubMed
      48. Chung YH, Cho NH, Garcia MI, Lee SH, Feng P, Jung JU. Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein. J Virol. 2004 Jun; 78(12):6489-97. PMID: 15163742.
        View in: PubMed
      49. Feng P, Scott CW, Cho NH, Nakamura H, Chung YH, Monteiro MJ, Jung JU. Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation. Mol Cell Biol. 2004 May; 24(9):3938-48. PMID: 15082787.
        View in: PubMed
      50. Park J, Cho NH, Choi JK, Feng P, Choe J, Jung JU. Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts. J Virol. 2003 Aug; 77(16):9041-51. PMID: 12885920.
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      51. Feng P, Park J, Lee BS, Lee SH, Bram RJ, Jung JU. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J Virol. 2002 Nov; 76(22):11491-504. PMID: 12388711.
        View in: PubMed
      52. Everly DN, Feng P, Mian IS, Read GS. mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease. J Virol. 2002 Sep; 76(17):8560-71. PMID: 12163576.
        View in: PubMed
      53. Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry JW, Chen SF, Zhou JX, Cho YH, Ullrich S, Kanakaraj P, Carrell J, Boyd E, Olsen HS, Hu G, Pukac L, Liu D, Ni J, Kim S, Gentz R, Feng P, Moore PA, Ruben SM, Wei P. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002 Mar; 16(3):479-92. PMID: 11911831.
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