Young-Kwon Hong, PhD

Title(s)Professor of Surgery
SchoolKeck School of Medicine of Usc
Address1450 Biggy St. NRT6501
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 7825
ORCID ORCID Icon0000-0001-8245-875X Additional info
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    Other Positions
    Title(s)Chief, Division of Basic Sciences

    Collapse Biography 
    Collapse Education and Training
    Korea University, SeoulBA1990Agricultural Chemistry
    University of California, DavisPh.D.1997Microbiology
    Harvard Institute of Human Genetics, BostonPostdoctoral2001Embryonic Stem Cells

    Collapse Overview 
    Collapse Overview
    Dr. Hong obtained his Ph.D. in Microbiology at the University of California, Davis. He then studied global genetic and epigenetic regulations in mouse embryonic stem cells at the Harvard Institute of Human Genetics during his post-doctoral fellowship. In 2001, he was recruited as an Instructor at the Cutaneous Biology Research Center, Massachusetts General Hospital, and Harvard Medical School. After 5 years, he joined the Department of Surgery, Keck School of Medicine in 2005. Dr. Hong is a Professor of Surgery and affiliated with Norris Comprehensive Cancer Center. He also serves as the Director of Translational and Basic Science Research of Surgery Department and supervises all basis and translational research in the department. His main research interest is to understand the molecular and cellular controls of tissue fluid homeostasis in health and disease, including cancer, vascular malformation, brain fluid outflow, inflammation, viral infection, and wound healing, and to translate the knowledge to benefit human health. Dr. Hong received numerous awards for his outstanding research accomplishments, including the Seungman Cha Young Scientist Award, the STOP CANCER Award, Margaret E. Early Medical Research Foundation Young Investigator Award, James H. Zumberge Innovation Research Award, Concern Foundation Young Scientist Award, American Heart Association Award, The Wright Foundation Young Investigator Award, The U.S. Department Of Defense Congressionally Directed Medical Research Programs Breast Cancer Idea Award, March Of Dime Birth Defect Foundation Scholar Award, and American Cancer Society Research Scholar Award. Dr. Hong has trained and mentored more than 80 students (high school, undergraduate, graduate, and medical school), post-doctoral fellows, surgical residents, visiting scholars, and junior faculty members during the past 15 years at the Keck School of Medicine.

    The research interests in the Hong laboratory are listed below.

    1. Lymphatic Development and Differentiation
    Although Hippocrates simultaneously discovered the blood and lymphatic system, the lymphatic system has been extremely understudied despite its vital role in human health and diseases, compared to the blood vascular system. About 100 years ago, Sabin proposed that lymphatics are generated from the blood vascular system. This Sabin’s theory has recently been confirmed using newly discovered molecular and cellular markers and research tools. We are interested in how various signal pathways control lymphatic development and differentiation. A better understanding of lymphatic development and differentiation will significantly help to treat many human diseases related to the lymphatic system.

    2. Organ-On-Chips
    We have recently launched an Organ-On-Chips program. Collaborating with other biomedical engineer groups, we aim to grow blood and lymphatic vessels on a chip to investigate the mechanisms of physiological and pathological angiogenesis and lymphangiogenesis. This new technology is powerful as it enables us to study the biology of vascular development and differentiation and models our organs and tissues for many biomedical and therapeutic purposes.

    3. Development of Lymphedema Therapy
    Surgery-related lymphedema is the leading morbidity that is associated with breast cancer survivors. To date, non-invasive therapeutic approaches are unavailable for this disfiguring, painful and demoralizing illness. We have recently published the therapeutic efficacy of retinoic acid against surgery-associated lymphedema in the prestigious journal Circulation. Our study found that retinoic acid could regenerate damaged lymphatic system and prevent potential lymphedema using animal models. We aim further to confirm this new therapy in rats and large animals and eventually bring it to clinical trials. Because retinoic acids have been extensively studied for their medicinal properties and are already used in clinics for other diseases, the new approach presents great promise and hope to patients suffering from surgery-associated lymphedema.

    4. Fluid Homeostasis and Outflow Facility in the Eye
    The lymphatics play essential roles in tissue fluid homeostasis in the interstitial space. Similarly, Schlemm’s canal (SC), a specialized vascular structure in the eye, controls the fluid homeostasis of the eye's anterior chamber. SC is an endothelium-lined channel that encircles the margin of the cornea and drains the aqueous humor from the anterior chamber of the eye into the circulation through collector channels. As the intraocular pressure (IOP) is closely correlated with the aqueous humor outflow (AHO), SC plays a key role in regulating IOP in the eye. When the draining function of SC becomes compromised, the IOP could be dramatically elevated and damage the ocular nerve, possibly causing glaucoma. Directly connected to the aqueous vein, SC has long been thought to be a venous extension, whose inner wall is lined by blood vascular endothelial cells (BECs). Interestingly, SC has also been known to display molecular, structure, and functional features of lymphatic vessels, which are responsible for draining the interstitial fluids into the circulation. During development, lymphatic endothelial cells (LECs) are differentiated from BECs and this BEC-to-LEC fate reprogramming process is exquisitely controlled by a homeodomain transcription factor Prox1. Recently, my group, together with a vascular biology group in Korea, has published an exciting study, demonstrating that lymphatic regulator PROX1 determines SC integrity and identity. In addition, we have collaborated with other groups in two other studies on SC's development and maintenance. We are thrilled to utilize our expertise to understand better how fluid homeostasis and intraocular pressure are controlled in healthy and glaucoma eyes. We are interested in defining the molecular mechanism by which fluid flow directs the development and maintenance of SC through the shear stress regulator, Klf4. Our experience and resource would contribute to advancing the knowledge of the molecular controls of intraocular pressure with therapeutic implications for glaucoma.

    5. Stem Cell Research
    We study the molecular mechanism underlying the vascular differentiation of embryonic stem (ES) and adipose-derived stem cells (ADSC) with three goals. (a) to acquire a better understanding of the embryonic and postnatal genetic program that specifies vascular and lymphatic endothelial cells, (b) to develop technology that allows maximal differentiation efficiency for 3-D printing of organs, and (c) to acquire the clinical-grade vascular building blocks to treat vascular diseases, including vascular malformation and lymphedema.

    6. Cancer Development and Metastasis
    The majority of cancers recruit and invade lymphatic vessels for their metastasis. We are interested in how breast and colon cancers interact with lymphatic vessels to promote their metastasis. Our preliminary data suggest that tumor-induced tissue pressure could play a previously unidentified role in their spread. Separately, various pathogens, such as Kaposi sarcoma herpes virus (KSHV), directly infect vascular endothelial cells and cause neoplasm in HIV- and organ transplant patients. We are studying the molecular and cellular interactions between the host and the pathogens.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    USC Stimulating Access to Research in Residency (USC-StARR) Program
    NIH R38HL155773Jul 1, 2021 - Jun 30, 2025
    Role: Co-Principal Investigator
    NIH/NCI R01CA250065Aug 1, 2020 - Jul 31, 2025
    Role: Principal Investigator
    Prox1 Phosphorylation in Lymphatic Development and Function
    NIH R01DK114645Sep 1, 2018 - May 31, 2023
    Role: Principal Investigator
    Study of CEACAM as Novel KSHV Receptors for Lymphatic Endothelial Cells
    NIH R21DE027891Jun 7, 2018 - May 31, 2021
    Role: Principal Investigator
    Cooperative Regulation of Mechanotransduction for Lymphatic Valve Development by Prox1 and Nf-kB
    NIH R01HL141857May 1, 2018 - Apr 30, 2022
    Role: Principal Investigator
    Flow Dependent Development and Maintenance of Schlemm's Canal
    NIH R21EY026260Aug 1, 2016 - Jul 31, 2019
    Role: Principal Investigator
    Early Detection and Intervention of Surgery-Induced Lymphatic Insufficiency
    NIH R21HL119583Apr 4, 2014 - Mar 31, 2017
    Role: Principal Investigator
    Retinoic acid signaling in lymphangiogenesis
    NIH R01HL121036Jan 1, 2014 - Dec 31, 2018
    Role: Principal Investigator
    Molecular Basis of Nuchal Edema
    NIH R01HD059762Jan 15, 2009 - Dec 31, 2014
    Role: Principal Investigator
    A Lymphatic-specific fluorescent transgenic model
    NIH R21HL082643Jun 1, 2006 - May 31, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lymphatic endothelial cell RXRα is critical for 9-cis-retinoic acid-mediated lymphangiogenesis and prevention of secondary lymphedema. FASEB J. 2023 Jan; 37(1):e22674. Sung C, Jiao W, Park SY, Cooper M, Bouz A, Choi D, Jung E, Kim G, Hong YK, Wong AK. PMID: 36520015.
      View in: PubMed   Mentions:    Fields:    
    2. Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells. J Cell Mol Med. 2022 10; 26(20):5181-5194. De Zoysa P, Toubat O, Harvey DC, Yi C, Liu J, Cavallero S, Hong YK, Sucov HM, Kumar SR. PMID: 36082581; PMCID: PMC9575135.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Subconjunctival Lymphatics Respond to VEGFC and Anti-Metabolites in Rabbit and Mouse Eyes. Invest Ophthalmol Vis Sci. 2022 09 01; 63(10):16. Lee JY, Wu J, Liu Y, Saraswathy S, Zhou L, Bu Q, Su Y, Choi D, Park E, Strohmaier CA, Weinreb RN, Hong YK, Pan X, Huang AS. PMID: 36166215; PMCID: PMC9526361.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2. Sci Rep. 2022 06 23; 12(1):10623. Ko MK, Woo JI, Gonzalez JM, Kim G, Sakai L, Peti-Peterdi J, Kelber JA, Hong YK, Tan JC. PMID: 35739142; PMCID: PMC9226129.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion. Circ Res. 2022 07 08; 131(2):e2-e21. Choi D, Park E, Yu RP, Cooper MN, Cho IT, Choi J, Yu J, Zhao L, Yum JI, Yu JS, Nakashima B, Lee S, Seong YJ, Jiao W, Koh CJ, Baluk P, McDonald DM, Saraswathy S, Lee JY, Jeon NL, Zhang Z, Huang AS, Zhou B, Wong AK, Hong YK. PMID: 35701867; PMCID: PMC9308715.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. Prolymphangiogenic Effects of 9-cis Retinoic Acid Are Enhanced at Sites of Lymphatic Injury and Dependent on Treatment Duration in Experimental Postsurgical Lymphedema. Lymphat Res Biol. 2022 12; 20(6):640-650. Lee GK, Perrault DP, Bouz A, Pourmoussa AJ, Yu R, Kim SJ, Gardner D, Johnson M, Park SY, Park EK, Seong YJN, Lee S, Jung E, Choi D, Hong YK, Wong AK. PMID: 35584281; PMCID: PMC9810351.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    7. Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats. Part Fibre Toxicol. 2022 04 08; 19(1):27. Takeda T, Yamano S, Goto Y, Hirai S, Furukawa Y, Kikuchi Y, Misumi K, Suzuki M, Takanobu K, Senoh H, Saito M, Kondo H, Daghlian G, Hong YK, Yoshimatsu Y, Hirashima M, Kobashi Y, Okamoto K, Kishimoto T, Umeda Y. PMID: 35395797; PMCID: PMC8994297.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsPHPublic Health
    8. Perfusable micro-vascularized 3D tissue array for high-throughput vascular phenotypic screening. Nano Converg. 2022 Apr 08; 9(1):16. Yu J, Lee S, Song J, Lee SR, Kim S, Choi H, Kang H, Hwang Y, Hong YK, Jeon NL. PMID: 35394224; PMCID: PMC8994007.
      View in: PubMed   Mentions: 14  
    9. Pro-resolving lipid mediators in traumatic brain injury: emerging concepts and translational approach. Am J Transl Res. 2022; 14(3):1482-1494. Poblete RA, Arenas M, Sanossian N, Hong YK, Freeman WD, Lyden PD, Louie SG. PMID: 35422939; PMCID: PMC8991125.
      View in: PubMed   Mentions: 3  
    10. PROX1, a Key Mediator of the Anti-Proliferative Effect of Rapamycin on Hepatocellular Carcinoma Cells. Cells. 2022 01 27; 11(3). Kwon S, Ban K, Hong YK, Sung JS, Choi I. PMID: 35159256; PMCID: PMC8834064.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. VE-Cadherin: A Critical Sticking Point for Lymphatic System Maintenance: Role of VE-Cadherin in Lymphatic Maintenance. Circ Res. 2022 01 07; 130(1):24-26. Nakashima BJ, Hong YK. PMID: 34995134; PMCID: PMC8979571.
      View in: PubMed   Mentions: 4     Fields:    
    12. Structural Confirmation of Lymphatic Outflow from Subconjunctival Blebs of Live Human Subjects. Ophthalmol Sci. 2021 Dec; 1(4). Lee JY, Heilweil G, Le P, Saraswathy S, Hong YK, Girkin CA, Huang AS. PMID: 35005679; PMCID: PMC8740887.
      View in: PubMed   Mentions: 6  
    13. Aqueous outflow channels and its lymphatic association: A review. Surv Ophthalmol. 2022 May-Jun; 67(3):659-674. Narayanaswamy A, Thakur S, Nongpiur ME, Schmetterer L, Hong YK, Huang AS, Wong TT. PMID: 34656556; PMCID: PMC9008077.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    14. Serial intravital imaging captures dynamic and functional endothelial remodeling with single-cell resolution. JCI Insight. 2021 05 24; 6(10). Desposito D, Schiessl IM, Gyarmati G, Riquier-Brison A, Izuhara AK, Kadoya H, Der B, Shroff UN, Hong YK, Peti-Peterdi J. PMID: 33848265; PMCID: PMC8262275.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    15. Terminating Cancer by Blocking VISTA as a Novel Immunotherapy: Hasta la vista, baby. Front Oncol. 2021; 11:658488. Yum JI, Hong YK. PMID: 33937071; PMCID: PMC8085549.
      View in: PubMed   Mentions: 9  
    16. Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis. J Clin Invest. 2021 03 01; 131(5). Furlong-Silva J, Cross SD, Marriott AE, Pionnier N, Archer J, Steven A, Merker SS, Mack M, Hong YK, Taylor MJ, Turner JD. PMID: 33434186; PMCID: PMC7919730.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. From Bench to Bedside: The Role of a Multidisciplinary Approach to Treating Patients with Lymphedema. Lymphat Res Biol. 2021 02; 19(1):11-16. Lentz R, Shin C, Bloom Z, Yamada K, Hong YK, Wong AK, Patel K. PMID: 33544026; PMCID: PMC8020565.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Ras Pathways on Prox1 and Lymphangiogenesis: Insights for Therapeutics. Front Cardiovasc Med. 2020; 7:597374. Bui K, Hong YK. PMID: 33263009; PMCID: PMC7688453.
      View in: PubMed   Mentions: 18  
    19. Aqueous humour outflow imaging: seeing is believing. Eye (Lond). 2021 01; 35(1):202-215. Lee JY, Akiyama G, Saraswathy S, Xie X, Pan X, Hong YK, Huang AS. PMID: 33060830; PMCID: PMC7852535.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    20. Lymphatic Proliferation Ameliorates Pulmonary Fibrosis after Lung Injury. Am J Pathol. 2020 12; 190(12):2355-2375. Baluk P, Naikawadi RP, Kim S, Rodriguez F, Choi D, Hong YK, Wolters PJ, McDonald DM. PMID: 33039355; PMCID: PMC7734600.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    21. Organogenesis and distribution of the ocular lymphatic vessels in the anterior eye. JCI Insight. 2020 07 09; 5(13). Wu Y, Seong YJ, Li K, Choi D, Park E, Daghlian GH, Jung E, Bui K, Zhao L, Madhavan S, Daghlian S, Daghlian P, Chin D, Cho IT, Wong AK, Heur M, Zhang-Nunes S, Tan JC, Ema M, Wong TT, Huang AS, Hong YK. PMID: 32641580; PMCID: PMC7406257.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    22. The Lymphatic Cell Environment Promotes Kaposi Sarcoma Development by Prox1-Enhanced Productive Lytic Replication of Kaposi Sarcoma Herpes Virus. Cancer Res. 2020 08 01; 80(15):3130-3144. Choi D, Park E, Kim KE, Jung E, Seong YJ, Zhao L, Madhavan S, Daghlian G, Lee HH, Daghlian PT, Daghlian S, Bui K, Koh CJ, Wong AK, Cho IT, Hong YK. PMID: 32518204; PMCID: PMC7759148.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Functional, structural, and molecular identification of lymphatic outflow from subconjunctival blebs. Exp Eye Res. 2020 07; 196:108049. Akiyama G, Saraswathy S, Bogarin T, Pan X, Barron E, Wong TT, Kaneko MK, Kato Y, Hong Y, Huang AS. PMID: 32387381; PMCID: PMC7328765.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    24. Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps. PLoS One. 2020; 15(1):e0227599. Perrault DP, Lee GK, Bouz A, Sung C, Yu R, Pourmoussa AJ, Park SY, Kim GH, Jiao W, Patel KM, Hong YK, Wong AK. PMID: 31923917; PMCID: PMC6954070.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    25. A Pre-clinical Animal Model of Secondary Head and Neck Lymphedema. Sci Rep. 2019 12 04; 9(1):18264. Daneshgaran G, Lo AY, Paik CB, Cooper MN, Sung C, Jiao W, Park SY, Ni P, Yu RP, Vorobyova I, Jashashvili T, Hong YK, Kim GH, Conti PS, Chai Y, Wong AK. PMID: 31797883; PMCID: PMC6892928.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. Development. 2019 11 05; 146(21). Mahamud MR, Geng X, Ho YC, Cha B, Kim Y, Ma J, Chen L, Myers G, Camper S, Mustacich D, Witte M, Choi D, Hong YK, Chen H, Varshney G, Engel JD, Wang S, Kim TH, Lim KC, Srinivasan RS. PMID: 31582413; PMCID: PMC6857586.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    27. Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature. 2019 08; 572(7767):62-66. Ahn JH, Cho H, Kim JH, Kim SH, Ham JS, Park I, Suh SH, Hong SP, Song JH, Hong YK, Jeong Y, Park SH, Koh GY. PMID: 31341278.
      View in: PubMed   Mentions: 257     Fields:    Translation:AnimalsCells
    28. Prevention of postsurgical lymphedema via immediate delivery of sustained-release 9-cis retinoic acid to the lymphedenectomy site. J Surg Oncol. 2020 Jan; 121(1):100-108. Daneshgaran G, Paik CB, Cooper MN, Sung C, Lo A, Jiao W, Park SY, Kim GH, Hong YK, Wong AK. PMID: 31240729; PMCID: PMC6930358.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    29. Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation. Stem Cells Transl Med. 2019 09; 8(9):925-934. Johnson MB, Niknam-Bienia S, Soundararajan V, Pang B, Jung E, Gardner DJ, Xu X, Park SY, Wang C, Chen X, Baker RY, Chen M, Hong YK, Li W, Wong AK. PMID: 31020798; PMCID: PMC6708065.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance. JCI Insight. 2019 03 07; 4(5). Choi D, Park E, Jung E, Cha B, Lee S, Yu J, Kim PM, Lee S, Hong YJ, Koh CJ, Cho CW, Wu Y, Li Jeon N, Wong AK, Shin L, Kumar SR, Bermejo-Moreno I, Srinivasan RS, Cho IT, Hong YK. PMID: 30676326; PMCID: PMC6483520.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    31. YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis. Circ Res. 2019 01 18; 124(2):225-242. Cho H, Kim J, Ahn JH, Hong YK, Mäkinen T, Lim DS, Koh GY. PMID: 30582452.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    32. Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis. Lymphat Res Biol. 2019 Feb; 17(1):19-29. Perrault DP, Lee GK, Park SY, Lee S, Choi D, Jung E, Seong YJ, Park EK, Sung C, Yu R, Bouz A, Pourmoussa A, Kim SJ, Hong YK, Wong AK. PMID: 30648916; PMCID: PMC6388710.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    33. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling. Cell Rep. 2018 10 16; 25(3):571-584.e5. Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS. PMID: 30332639; PMCID: PMC6264919.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    34. Exosomes as a Communication Tool Between the Lymphatic System and Bladder Cancer. Int Neurourol J. 2018 Sep; 22(3):220-224. Park RJ, Hong YJ, Wu Y, Kim PM, Hong YK. PMID: 30286586; PMCID: PMC6177726.
      View in: PubMed   Mentions: 7  
    35. Human Acellular Dermis as Spacer for Small-Joint Arthroplasty: Analysis of Revascularization in a Rabbit Trapeziectomy Model. Plast Reconstr Surg. 2018 09; 142(3):679-686. Banks K, Squitieri L, Bramos A, Johnson MB, Gardner DJ, Pourmoussa AJ, Jung E, Lee GK, Perrault DP, Fedenko A, Kim GH, Han B, Hong YK, Kulber DA, Wong AK. PMID: 29878993.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    36. Endothelial lineage-specific interaction of Mycobacterium tuberculosis with the blood and lymphatic systems. Tuberculosis (Edinb). 2018 07; 111:1-7. Kim PM, Lee JJ, Choi D, Eoh H, Hong YK. PMID: 30029892; PMCID: PMC7173645.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. Lymphatic exosomes promote dendritic cell migration along guidance cues. J Cell Biol. 2018 06 04; 217(6):2205-2221. Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong YK, Bennett KL, Kain R, Detmar M, Sixt M, Jackson DG, Kerjaschki D. PMID: 29650776; PMCID: PMC5987709.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    38. Postnatal development of lymphatic vasculature in the brain meninges. Dev Dyn. 2018 05; 247(5):741-753. Izen RM, Yamazaki T, Nishinaka-Arai Y, Hong YK, Mukouyama YS. PMID: 29493038; PMCID: PMC5902435.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    39. Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):1298-1303. Souma T, Thomson BR, Heinen S, Carota IA, Yamaguchi S, Onay T, Liu P, Ghosh AK, Li C, Eremina V, Hong YK, Economides AN, Vestweber D, Peters KG, Jin J, Quaggin SE. PMID: 29358379; PMCID: PMC5819405.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    40. Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. mBio. 2018 01 16; 9(1). Lee HR, Li F, Choi UY, Yu HR, Aldrovandi GM, Feng P, Gao SJ, Hong YK, Jung JU. PMID: 29339432; PMCID: PMC5770555.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    41. Advances in Renal Cell Imaging. Semin Nephrol. 2018 01; 38(1):52-62. Gyarmati G, Kadoya H, Moon JY, Burford JL, Ahmadi N, Gill IS, Hong YK, Dér B, Peti-Peterdi J. PMID: 29291762; PMCID: PMC5773263.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    42. Deep tissue analysis of distal aqueous drainage structures and contractile features. Sci Rep. 2017 12 06; 7(1):17071. Gonzalez JM, Ko MK, Hong YK, Weigert R, Tan JCH. PMID: 29213129; PMCID: PMC5719038.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    43. Genetic and neuronal regulation of sleep by neuropeptide VF. Elife. 2017 11 06; 6. Lee DA, Andreev A, Truong TV, Chen A, Hill AJ, Oikonomou G, Pham U, Hong YK, Tran S, Glass L, Sapin V, Engle J, Fraser SE, Prober DA. PMID: 29106375; PMCID: PMC5705210.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    44. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017 Oct 02; 127(10):3877-3896. Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, Koh GY. PMID: 28920924; PMCID: PMC5617682.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    45. Rapamycin reversal of VEGF-C-driven lymphatic anomalies in the respiratory tract. JCI Insight. 2017 Aug 17; 2(16). Baluk P, Yao LC, Flores JC, Choi D, Hong YK, McDonald DM. PMID: 28814666; PMCID: PMC5621869.
      View in: PubMed   Mentions: 26     Fields:    
    46. Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat. Sci Rep. 2017 07 17; 7(1):5577. Jung E, Gardner D, Choi D, Park E, Jin Seong Y, Yang S, Castorena-Gonzalez J, Louveau A, Zhou Z, Lee GK, Perrault DP, Lee S, Johnson M, Daghlian G, Lee M, Jin Hong Y, Kato Y, Kipnis J, Davis MJ, Wong AK, Hong YK. PMID: 28717161; PMCID: PMC5514086.
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    47. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 07 06; 21(1):78-90.e6. Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ. PMID: 28686870; PMCID: PMC5642297.
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    48. Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 06 20; 7(1):3876. Johnson MB, Pang B, Gardner DJ, Niknam-Benia S, Soundarajan V, Bramos A, Perrault DP, Banks K, Lee GK, Baker RY, Kim GH, Lee S, Chai Y, Chen M, Li W, Kwong L, Hong YK, Wong AK. PMID: 28634413; PMCID: PMC5478660.
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    49. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. PMID: 28263185; PMCID: PMC5373895.
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    50. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. PMID: 28167653; PMCID: PMC6300148.
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    51. Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid. Ann Surg. 2016 08; 264(2):353-61. Bramos A, Perrault D, Yang S, Jung E, Hong YK, Wong AK. PMID: 26655920; PMCID: PMC7513676.
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    52. Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells. PLoS One. 2016; 11(6):e0157126. Hong M, Jung E, Yang S, Jung W, Seong YJ, Park E, Bramos A, Kim KE, Lee S, Daghlian G, Seo JI, Choi I, Choi IS, Koh CJ, Kobielak A, Ying QL, Johnson M, Gardner D, Wong AK, Choi D, Hong YK. PMID: 27280889; PMCID: PMC4900649.
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    53. Limited versus total epithelial debridement ocular surface injury: Live fluorescence imaging of hemangiogenesis and lymphangiogenesis in Prox1-GFP/Flk1::Myr-mCherry mice. Biochim Biophys Acta. 2016 10; 1860(10):2148-56. Chang JH, Putra I, Huang YH, Chang M, Han K, Zhong W, Gao X, Wang S, Dugas-Ford J, Nguyen T, Hong YK, Azar DT. PMID: 27233452; PMCID: PMC4961530.
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    54. DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C. J Cell Sci. 2016 07 01; 129(13):2573-85. Klein S, Dieterich LC, Mathelier A, Chong C, Sliwa-Primorac A, Hong YK, Shin JW, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E, FANTOM consortium, Carninci P, Hayashizaki Y, Forrest AR, Wasserman WW, Detmar M. PMID: 27199372; PMCID: PMC7376900.
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    55. Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Exp Eye Res. 2017 05; 158:161-170. Gonzalez JM, Ko MK, Masedunskas A, Hong YK, Weigert R, Tan JCH. PMID: 27179411; PMCID: PMC5403624.
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    56. Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1. Lipids Health Dis. 2016 Feb 27; 15:41. Kwon S, Jeon JS, Kim SB, Hong YK, Ahn C, Sung JS, Choi I. PMID: 26922671; PMCID: PMC4769820.
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    57. Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells. Cancer Res. 2016 Feb 01; 76(3):582-93. Choi D, Ramu S, Park E, Jung E, Yang S, Jung W, Choi I, Lee S, Kim KE, Seong YJ, Hong M, Daghlian G, Kim D, Shin E, Seo JI, Khatchadourian V, Zou M, Li W, De Filippo R, Kokorowski P, Chang A, Kim S, Bertoni A, Furlanetto TW, Shin S, Li M, Chen Y, Wong A, Koh C, Geliebter J, Hong YK. PMID: 26609053; PMCID: PMC4738160.
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    58. A Model of Lymphangioleiomyomatosis in a Three-Dimensional Culture System. Lymphat Res Biol. 2015 Dec; 13(4):248-52. Kumasaka T, Hoshika Y, Kobayashi E, Mitani K, Okura MK, Hong YK, Takahashi K, Seyama K. PMID: 26574997; PMCID: PMC7141556.
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    59. DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium. Cell Rep. 2015 Nov 17; 13(7):1493-1504. Dieterich LC, Klein S, Mathelier A, Sliwa-Primorac A, Ma Q, Hong YK, Shin JW, Hamada M, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E, Carninci P, Hayashizaki Y, Forrest ARR, Wasserman WW, Detmar M. PMID: 26549461.
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    60. Intravital imaging of intestinal lacteals unveils lipid drainage through contractility. J Clin Invest. 2015 Nov 02; 125(11):4042-52. Choe K, Jang JY, Park I, Kim Y, Ahn S, Park DY, Hong YK, Alitalo K, Koh GY, Kim P. PMID: 26436648; PMCID: PMC4639990.
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    61. Simultaneous in vivo imaging of blood and lymphatic vessel growth in Prox1-GFP/Flk1::myr-mCherry mice. FEBS J. 2015 Apr; 282(8):1458-1467. Zhu J, Dugas-Ford J, Chang M, Purta P, Han KY, Hong YK, Dickinson ME, Rosenblatt MI, Chang JH, Azar DT. PMID: 25688651; PMCID: PMC4400230.
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    62. TH2 cells and their cytokines regulate formation and function of lymphatic vessels. Nat Commun. 2015 Feb 04; 6:6196. Shin K, Kataru RP, Park HJ, Kwon BI, Kim TW, Hong YK, Lee SH. PMID: 25648335.
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    63. Prox1 expression in the endolymphatic sac revealed by whole-mount fluorescent imaging of Prox1-GFP transgenic mice. Biochem Biophys Res Commun. 2015 Jan 30; 457(1):19-22. Miyashita T, Burford JL, Hong YK, Gevorgyan H, Lam L, Hoshikawa H, Mori N, Peti-Peterdi J. PMID: 25529452.
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    64. A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest. 2014 Oct; 124(10):4320-4. Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, Onay T, Chen H, Yamaguchi S, Economides AN, Flenniken A, Gale NW, Hong YK, Fawzi A, Liu X, Kume T, Quaggin SE. PMID: 25202984; PMCID: PMC4191022.
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    65. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest. 2014 Sep; 124(9):3960-74. Park DY, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong KY, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong YK, Koh GY. PMID: 25061877; PMCID: PMC4153702.
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    66. Novel characterization and live imaging of Schlemm's canal expressing Prox-1. PLoS One. 2014; 9(5):e98245. Truong TN, Li H, Hong YK, Chen L. PMID: 24827370; PMCID: PMC4020937.
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    67. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation. Am J Pathol. 2014 May; 184(5):1577-92. Baluk P, Adams A, Phillips K, Feng J, Hong YK, Brown MB, McDonald DM. PMID: 24631179; PMCID: PMC4005985.
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    68. Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis. J Dermatol Sci. 2014 May; 74(2):106-15. Kunstfeld R, Hawighorst T, Streit M, Hong YK, Nguyen L, Brown LF, Detmar M. PMID: 24507936; PMCID: PMC3975683.
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    69. CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development. Int J Cancer. 2014 Jul 01; 135(1):232-7. Lee YS, Choi D, Kim NY, Yang S, Jung E, Hong M, Yang D, Lenz HJ, Hong YK. PMID: 24338666; PMCID: PMC4166491.
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    70. Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. 2014 Feb 01; 386(1):25-33. Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL, François M. PMID: 24361262.
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    71. Protective role of the lymphatics from sepsis. Blood. 2013 Sep 26; 122(13):2143-4. Hong YK. PMID: 24072845.
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    72. Localization and proliferation of lymphatic vessels in the tympanic membrane in normal state and regeneration. Biochem Biophys Res Commun. 2013 Oct 25; 440(3):371-3. Miyashita T, Burford JL, Hong YK, Gevorgyan H, Lam L, Mori N, Peti-Peterdi J. PMID: 24055876.
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    73. Novel biomarkers of arterial and venous ischemia in microvascular flaps. PLoS One. 2013; 8(8):e71628. Nguyen GK, Hwang BH, Zhang Y, Monahan JF, Davis GB, Lee YS, Ragina NP, Wang C, Zhou ZY, Hong YK, Spivak RM, Wong AK. PMID: 23977093; PMCID: PMC3743756.
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    74. Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration. Angiogenesis. 2013 Jan; 16(1):29-44. Choi I, Lee YS, Chung HK, Choi D, Ecoiffier T, Lee HN, Kim KE, Lee S, Park EK, Maeng YS, Kim NY, Ladner RD, Petasis NA, Koh CJ, Chen L, Lenz HJ, Hong YK. PMID: 22945845; PMCID: PMC4166493.
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    75. Lymphatic reprogramming by Kaposi sarcoma herpes virus promotes the oncogenic activity of the virus-encoded G-protein-coupled receptor. Cancer Res. 2012 Nov 15; 72(22):5833-42. Aguilar B, Choi I, Choi D, Chung HK, Lee S, Yoo J, Lee YS, Maeng YS, Lee HN, Park E, Kim KE, Kim NY, Baik JM, Jung JU, Koh CJ, Hong YK. PMID: 22942256; PMCID: PMC3500425.
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    76. Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus. PLoS Pathog. 2012; 8(6):e1002770. Yoo J, Lee HN, Choi I, Choi D, Chung HK, Kim KE, Lee S, Aguilar B, Kang J, Park E, Lee YS, Maeng YS, Kim NY, Koh CJ, Hong YK. PMID: 22719258; PMCID: PMC3375311.
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    77. Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. Br J Cancer. 2012 May 22; 106(11):1833-41. Lee YS, Choi I, Ning Y, Kim NY, Khatchadourian V, Yang D, Chung HK, Choi D, LaBonte MJ, Ladner RD, Nagulapalli Venkata KC, Rosenberg DO, Petasis NA, Lenz HJ, Hong YK. PMID: 22617157; PMCID: PMC3364111.
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    78. The new era of the lymphatic system: no longer secondary to the blood vascular system. Cold Spring Harb Perspect Med. 2012 Apr; 2(4):a006445. Choi I, Lee S, Hong YK. PMID: 22474611; PMCID: PMC3312397.
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    79. 9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema. Circulation. 2012 Feb 21; 125(7):872-82. Choi I, Lee S, Kyoung Chung H, Suk Lee Y, Eui Kim K, Choi D, Park EK, Yang D, Ecoiffier T, Monahan J, Chen W, Aguilar B, Lee HN, Yoo J, Koh CJ, Chen L, Wong AK, Hong YK. PMID: 22275501; PMCID: PMC3327127.
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    80. The Primo Vascular System. Detection of the Primo Vessels in the Rodent Thoracic Lymphatic Ducts. 2012. Choi I, Jeong HK, Hong YK .
    81. Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models. Int J Cancer. 2011 May 01; 128(9):2038-49. Ning Y, Manegold PC, Hong YK, Zhang W, Pohl A, Lurje G, Winder T, Yang D, LaBonte MJ, Wilson PM, Ladner RD, Lenz HJ. PMID: 20648559; PMCID: PMC3039715.
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    82. Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse. Blood. 2011 Jan 06; 117(1):362-5. Choi I, Chung HK, Ramu S, Lee HN, Kim KE, Lee S, Yoo J, Choi D, Lee YS, Aguilar B, Hong YK. PMID: 20962325; PMCID: PMC3037757.
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    83. Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol. 2010 Oct; 177(4):2124-33. Zhou F, Chang Z, Zhang L, Hong YK, Shen B, Wang B, Zhang F, Lu G, Tvorogov D, Alitalo K, Hemmings BA, Yang Z, He Y. PMID: 20724596; PMCID: PMC2947305.
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    84. Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. PLoS Pathog. 2010 Aug 12; 6(8):e1001046. Yoo J, Kang J, Lee HN, Aguilar B, Kafka D, Lee S, Choi I, Lee J, Ramu S, Haas J, Koh CJ, Hong YK. PMID: 20730087; PMCID: PMC2921153.
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    85. Novel discovery of LYVE-1 expression in the hyaloid vascular system. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6157-61. Zhang H, Tse J, Hu X, Witte M, Bernas M, Kang J, Tilahun F, Hong YK, Qiu M, Chen L. PMID: 20688736; PMCID: PMC3055750.
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    86. Heterogeneity and plasticity of lymphatic endothelial cells. Semin Thromb Hemost. 2010 Apr; 36(3):352-61. Lee S, Choi I, Hong YK. PMID: 20490985; PMCID: PMC3461948.
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    87. Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. J Clin Invest. 2010 May; 120(5):1694-707. Lin FJ, Chen X, Qin J, Hong YK, Tsai MJ, Tsai SY. PMID: 20364082; PMCID: PMC2860940.
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    88. An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood. 2010 Jul 08; 116(1):140-50. Kang J, Yoo J, Lee S, Tang W, Aguilar B, Ramu S, Choi I, Otu HH, Shin JW, Dotto GP, Koh CJ, Detmar M, Hong YK. PMID: 20351309; PMCID: PMC2904577.
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    89. The origin of Kaposi sarcoma tumor cells. Kaposi sarcoma. A model of oncogenesis. 2010; 123-138. Aguilar B and Hong YK.
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    91. Phosphate-buffered saline-based nucleofection of primary endothelial cells. Anal Biochem. 2009 Mar 15; 386(2):251-5. Kang J, Ramu S, Lee S, Aguilar B, Ganesan SK, Yoo J, Kalra VK, Koh CJ, Hong YK. PMID: 19150324; PMCID: PMC2677097.
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    92. Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood. 2009 Feb 19; 113(8):1856-9. Lee S, Kang J, Yoo J, Ganesan SK, Cook SC, Aguilar B, Ramu S, Lee J, Hong YK. PMID: 18815287; PMCID: PMC2647678.
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    93. Current understanding of lymphatic system development. Endothelial Biomedicine. 2007; 1533-1567 . Kafka, D. Hong YK.
    94. Alcian blue staining method to visualize bonghan threads inside large caliber lymphatic vessels and x-ray microtomography to reveal their microchannels. Lymphat Res Biol. 2006; 4(4):181-90. Lee C, Seol SK, Lee BC, Hong YK, Je JH, Soh KS. PMID: 17394401.
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    95. Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell. 2006 Feb; 17(2):576-84. Shin JW, Min M, Larrieu-Lahargue F, Canron X, Kunstfeld R, Nguyen L, Henderson JE, Bikfalvi A, Detmar M, Hong YK. PMID: 16291864; PMCID: PMC1356570.
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    96. Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression. J Virol. 2005 Nov; 79(22):14371-82. Chang H, Dittmer DP, Shin YC, Chul SY, Hong Y, Jung JU. PMID: 16254371; PMCID: PMC1280196.
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    97. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 2005 Mar; 166(3):913-21. Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK, Detmar M. PMID: 15743802; PMCID: PMC1602360.
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    98. Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1. Br J Dermatol. 2005 Jan; 152(1):115-21. Yano K, Kadoya K, Kajiya K, Hong YK, Detmar M. PMID: 15656811.
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    99. Development of the lymphatic vascular system: a mystery unravels. Dev Dyn. 2004 Nov; 231(3):462-73. Hong YK, Shin JW, Detmar M. PMID: 15376314.
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    100. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. J Biol Chem. 2004 Sep 10; 279(37):38597-602. Kim KT, Ongusaha PP, Hong YK, Kurdistani SK, Nakamura M, Lu KP, Lee SW. PMID: 15247272.
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    101. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet. 2004 Jul; 36(7):683-5. Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, Sage DR, Libermann T, Dezube BJ, Fingeroth JD, Detmar M. PMID: 15220917.
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    102. VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J. 2004 Jul; 18(10):1111-3. Hong YK, Lange-Asschenfeldt B, Velasco P, Hirakawa S, Kunstfeld R, Brown LF, Bohlen P, Senger DR, Detmar M. PMID: 15132990.
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    103. Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia. Blood. 2004 Aug 15; 104(4):1048-57. Kunstfeld R, Hirakawa S, Hong YK, Schacht V, Lange-Asschenfeldt B, Velasco P, Lin C, Fiebiger E, Wei X, Wu Y, Hicklin D, Bohlen P, Detmar M. PMID: 15100155.
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    104. Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression. J Invest Dermatol. 2004 Jan; 122(1):201-8. Yano K, Kajiya K, Ishiwata M, Hong YK, Miyakawa T, Detmar M. PMID: 14962109.
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    105. An N-terminal 80 kDa recombinant fragment of human thrombospondin-2 inhibits vascular endothelial growth factor induced endothelial cell migration in vitro and tumor growth and angiogenesis in vivo. J Invest Dermatol. 2003 Dec; 121(6):1536-43. Noh YH, Matsuda K, Hong YK, Kunstfeld R, Riccardi L, Koch M, Oura H, Dadras SS, Streit M, Detmar M. PMID: 14675207.
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    106. Prox1, master regulator of the lymphatic vasculature phenotype. Cell Tissue Res. 2003 Oct; 314(1):85-92. Hong YK, Detmar M. PMID: 12883994.
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    107. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003 Jul 15; 22(14):3546-56. Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M. PMID: 12853470; PMCID: PMC165612.
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    108. Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Am J Pathol. 2003 Feb; 162(2):575-86. Hirakawa S, Hong YK, Harvey N, Schacht V, Matsuda K, Libermann T, Detmar M. PMID: 12547715; PMCID: PMC1851142.
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    109. Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn. 2002 Nov; 225(3):351-7. Hong YK, Harvey N, Noh YH, Schacht V, Hirakawa S, Detmar M, Oliver G. PMID: 12412020.
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    110. Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol. 2002 Apr; 160(4):1381-92. Hawighorst T, Skobe M, Streit M, Hong YK, Velasco P, Brown LF, Riccardi L, Lange-Asschenfeldt B, Detmar M. PMID: 11943723; PMCID: PMC1867215.
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    111. Non-disruptive PNA-FISH protocol for formalin-fixed and paraffin-embedded tissue sections. Biotechniques. 2001 Sep; 31(3):472, 475-6. Kim DH, Hong YK, Egholm M, Strauss WM. PMID: 11570488.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    112. PNA interference mapping demonstrates functional domains in the noncoding RNA Xist. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9215-20. Beletskii A, Hong YK, Pehrson J, Egholm M, Strauss WM. PMID: 11481485; PMCID: PMC55400.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    113. Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism. EMBO J. 2001 Jun 01; 20(11):2631-40. Hawighorst T, Velasco P, Streit M, Hong YK, Kyriakides TR, Brown LF, Bornstein P, Detmar M. PMID: 11387198; PMCID: PMC125494.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    114. Development of two bacterial artificial chromosome shuttle vectors for a recombination-based cloning and regulated expression of large genes in mammalian cells. Anal Biochem. 2001 Apr 01; 291(1):142-8. Hong YK, Kim DH, Beletskii A, Lee C, Memili E, Strauss WM. PMID: 11262167.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    115. Murine Xist RNA isoforms are different at their 3' ends: a role for differential polyadenylation. Gene. 2001 Mar 21; 266(1-2):131-7. Memili E, Hong YK, Kim DH, Ontiveros SD, Strauss WM. PMID: 11290427.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    116. The essential function of Not1 lies within the Ccr4-Not complex. J Mol Biol. 2000 Oct 20; 303(2):131-43. Maillet L, Tu C, Hong YK, Shuster EO, Collart MA. PMID: 11023781.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    117. A revision of the human XIST gene organization and structural comparison with mouse Xist. Mamm Genome. 2000 Mar; 11(3):220-4. Hong YK, Ontiveros SD, Strauss WM. PMID: 10723727.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    118. Tetracycline-resistant gene cassette designed for construction of mutant libraries of a target gene. Biotechniques. 1999 Oct; 27(4):682-5. Hong YK. PMID: 10524306.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    119. A new structure for the murine Xist gene and its relationship to chromosome choice/counting during X-chromosome inactivation. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6829-34. Hong YK, Ontiveros SD, Chen C, Strauss WM. PMID: 10359798; PMCID: PMC22001.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    120. Single base discrimination of CENP-B repeats on mouse and human Chromosomes with PNA-FISH. Mamm Genome. 1999 Jan; 10(1):13-8. Chen C, Hong YK, Ontiveros SD, Egholm M, Strauss WM. PMID: 9892726.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
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