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    Preet M Chaudhary, MD, PhD

    TitleProfessor of Medicine
    SchoolKeck School of Medicine of USC
    Address1441 Eastlake Ave.
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 865 3950
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      Other Positions
      TitleBloom Family Chair in Lymphoma Research

      TitleChief, Nohl Division of Hematology and Center For Blood Diseases in The Department of Medicine

      TitleDirector For Bone Marrow Transplant

      Collapse Overview 
      Collapse Overview
      Preet M. Chaudhary, M.D., Ph.D. is chief of the Jane Anne Nohl Division of Hematology and Center for the study of Blood Diseases in the Department of Medicine, and coleader of the Molecular Genetics Program at the USC Norris Comprehensive Cancer Center. He is also Professor of Medicine, Ronald H. Bloom Family Chair in Lymphoma Research, and Program Director of the USC/Norris Blood and Marrow Transplant Program.

      As a physician-scientist dedicated to hematologic oncology, Dr. Chaudhary has research interests in several areas of cancer, including AIDS-associated cancers, cancer drug resistance, biology of normal and leukemic hematopoietic stem cells, programmed cell death and cellular signaling. He is also interested in molecularly targeted and cellular therapies for leukemias, lymphomas, multiple myeloma and solid tumors. Current work in Dr. Chaudhary's laboratory is focused on developing novel strategies to improve the outcome of stem cell transplantation and the use of chimeric antigen receptor modified T cells for the treatment of cancer.

      Dr. Chaudhary holds six U.S. patents and has published in some of the top scientific journals, including Cell, Immunity, JNCI, PNAS and Blood. He has served as a peer-reviewer for several national and international cancer research funding agencies and has been elected to the prestigious American Society for Clinical Investigations, an honor society of the top physician-scientists in the country.

      Collapse Biography 
      Collapse Awards and Honors
      Leukemia Lymphoma Society2005  - 2008Translational Research Award
      Leukemia Lymphoma Society2008  - 2011Translational Research Award
      Multiple Myeloma Research Foundation2005  - 2006Senior Research Award
      2004American Society for Clinical Investigations
      Leukemia Research Foundation1999  - 2000New Investigator Award
      Howard Hughes Institutes1998  - 2001New Faculty Start-Up Award
      Damon Runyon-Walter Winchell Foundation1995  - 1998Postdoctoral Fellowship
      March of Dimes Birth Defects Foundation1990  - 1992Pre-doctoral Fellowship
      1986Second Prize in Ophthalmology
      1986Gold Medal in Surgery
      1985Second Prize in Pathology
      1984  - 1985Distinctions in Anatomy, Physiology Biochemistry and Pharmacology
      1984Honors in First Professional M.B.B.S
      1981Pre-Medical University Merit Certificate (First Rank in the College)
      1981  - 1986National Talent Search Scholarship

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      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Matta H, Gopalakrishnan R, Choi S, Prakash R, Natarajan V, Prins R, Gong S, Chitnis SD, Kahn M, Han X, Chaudhary V, Soni A, Sernas J, Khan P, Wang D, Chaudhary P. Development and characterization of a novel luciferase based cytotoxicity assay. Sci Rep. 2018 Jan 09; 8(1):199. PMID: 29317736.
        View in: PubMed
      2. Aldoss I, Douer D, Behrendt CE, Chaudhary P, Mohrbacher A, Vrona J, Pullarkat V. Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic leukemia. Eur J Haematol. 2016 Apr; 96(4):375-80. PMID: 26095294.
        View in: PubMed
      3. Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, Sun F, Waterman M, Chen JJ, Chaudhary P, Loscalzo J, Crandall E, Zhou XJ. DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. PMID: 24895436; PMCID: PMC4086092.
      4. Tolani B, Matta H, Gopalakrishnan R, Punj V, Chaudhary P. NEMO is essential for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process. J Virol. 2014 Jun; 88(11):6345-54. PMID: 24672029; PMCID: PMC4093867.
      5. Gopalakrishnan R, Matta H, Chaudhary P. A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-?B. Clin Cancer Res. 2013 Sep 15; 19(18):5016-26. PMID: 23881928; PMCID: PMC3804723.
      6. Graham C, Matta H, Yang Y, Yi H, Suo Y, Tolani B, Chaudhary P. Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-?B activation. J Virol. 2013 Feb; 87(4):2242-52. PMID: 23236068; PMCID: PMC3571451.
      7. Punj V, Matta H, Chaudhary P. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One. 2012; 7(5):e37498. PMID: 22624040; PMCID: PMC3356309.
      8. Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary P. Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-?B pathway independent of TRAF6, TAK1 and LUBAC. PLoS One. 2012; 7(5):e36601. PMID: 22590573; PMCID: PMC3348130.
      9. Yang Y, Groshong JS, Matta H, Gopalakrishnan R, Yi H, Chaudhary P. Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem. 2011 Aug 12; 286(32):27988-97. PMID: 21705340; PMCID: PMC3151044.
      10. Matta H, Gopalakrishnan R, Punj V, Yi H, Suo Y, Chaudhary P. A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner. J Biol Chem. 2011 Jun 17; 286(24):21555-64. PMID: 21531730; PMCID: PMC3122214.
      11. Ahmad A, Groshong JS, Matta H, Schamus S, Punj V, Robinson LJ, Gill PS, Chaudhary P. Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice. Cancer Biol Ther. 2010 Nov 15; 10(10):1033-40. PMID: 20818173; PMCID: PMC3047095.
      12. Lee HR, Lee S, Chaudhary P, Gill P, Jung JU. Immune evasion by Kaposi's sarcoma-associated herpesvirus. Future Microbiol. 2010 Sep; 5(9):1349-65. PMID: 20860481; PMCID: PMC3076960.
      13. Tolstov YL, Arora R, Scudiere SC, Busam K, Chaudhary P, Chang Y, Moore PS. Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood. 2010 Jun 10; 115(23):4973-4. PMID: 20538816; PMCID: PMC2890166.
      14. Liu R, Gong M, Li X, Zhou Y, Gao W, Tulpule A, Chaudhary P, Jung J, Gill PS. Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma. Blood. 2010 Jul 15; 116(2):297-305. PMID: 20442363; PMCID: PMC2910613.
      15. Punj V, Matta H, Chaudhary P. X-linked ectodermal dysplasia receptor is downregulated in breast cancer via promoter methylation. Clin Cancer Res. 2010 Feb 15; 16(4):1140-8. PMID: 20145163; PMCID: PMC2822888.
      16. Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary P, Jung J, Gill PS. KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood. 2010 Jan 28; 115(4):887-95. PMID: 19965636; PMCID: PMC2815507.
      17. Shuda M, Arora R, Kwun HJ, Feng H, Sarid R, Fernández-Figueras MT, Tolstov Y, Gjoerup O, Mansukhani MM, Swerdlow SH, Chaudhary P, Kirkwood JM, Nalesnik MA, Kant JA, Weiss LM, Moore PS, Chang Y. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer. 2009 Sep 15; 125(6):1243-9. PMID: 19499546.
        View in: PubMed
      18. Punj V, Matta H, Schamus S, Chaudhary P. Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells. BMC Med Genomics. 2009 Aug 06; 2:50. PMID: 19660139; PMCID: PMC2732924.
      19. Punj V, Matta H, Schamus S, Yang T, Chang Y, Chaudhary P. Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. Blood. 2009 May 28; 113(22):5660-8. PMID: 19324905; PMCID: PMC2689059.
      20. Moschos SJ, Chaudhary P, Kirkwood JM. Resolving "kinks" of chemotherapy in melanoma. J Natl Cancer Inst. 2008 Jun 18; 100(12):833-5. PMID: 18544737.
        View in: PubMed
      21. Lu G, Punj V, Chaudhary P. Proteasome inhibitor Bortezomib induces cell cycle arrest and apoptosis in cell lines derived from Ewing's sarcoma family of tumors and synergizes with TRAIL. Cancer Biol Ther. 2008 Apr; 7(4):603-8. PMID: 18223318.
        View in: PubMed
      22. Lacoste V, Nicot C, Gessain A, Valensi F, Gabarre J, Matta H, Chaudhary P, Mahieux R. In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v-GPCR become involved during the lytic cycle. Br J Haematol. 2007 Aug; 138(4):487-501. PMID: 17659053.
        View in: PubMed
      23. Matta H, Mazzacurati L, Schamus S, Yang T, Sun Q, Chaudhary P. Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation. J Biol Chem. 2007 Aug 24; 282(34):24858-65. PMID: 17597077.
        View in: PubMed
      24. Chugh P, Matta H, Schamus S, Zachariah S, Kumar A, Richardson JA, Smith AL, Chaudhary P. Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12885-90. PMID: 16120683; PMCID: PMC1200255.
      25. Sun Q, Matta H, Chaudhary P. Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat. Retrovirology. 2005 Feb 15; 2:9. PMID: 15713234; PMCID: PMC554086.
      26. Matta H, Chaudhary P. The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer Biol Ther. 2005 Jan; 4(1):77-82. PMID: 15662128.
        View in: PubMed
      27. Rathore N, Matta H, Chaudhary P. An evolutionary conserved pathway of nuclear factor-kappaB activation involving caspase-mediated cleavage and N-end rule pathway-mediated degradation of IkappaBalpha. J Biol Chem. 2004 Sep 17; 279(38):39358-65. PMID: 15252032.
        View in: PubMed
      28. Matta H, Chaudhary P. Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP). Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9399-404. PMID: 15190178; PMCID: PMC438988.
      29. Shivapurkar N, Toyooka S, Toyooka KO, Reddy J, Miyajima K, Suzuki M, Shigematsu H, Takahashi T, Parikh G, Pass HI, Chaudhary P, Gazdar AF. Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types. Int J Cancer. 2004 May 01; 109(5):786-92. PMID: 14999791.
        View in: PubMed
      30. Shindo M, Chaudhary P. The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation. Biochem Biophys Res Commun. 2004 Feb 27; 315(1):73-8. PMID: 15013427.
        View in: PubMed
      31. Sun Q, Zachariah S, Chaudhary P. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem. 2003 Dec 26; 278(52):52437-45. PMID: 14563855.
        View in: PubMed
      32. Matta H, Sun Q, Moses G, Chaudhary P. Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation. J Biol Chem. 2003 Dec 26; 278(52):52406-11. PMID: 14561765.
        View in: PubMed
      33. Tomar RS, Matta H, Chaudhary P. Use of adeno-associated viral vector for delivery of small interfering RNA. Oncogene. 2003 Aug 28; 22(36):5712-5. PMID: 12944921.
        View in: PubMed
      34. Kauppila S, Maaty WS, Chen P, Tomar RS, Eby MT, Chapo J, Chew S, Rathore N, Zachariah S, Sinha SK, Abrams JM, Chaudhary P. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Oncogene. 2003 Jul 31; 22(31):4860-7. PMID: 12894227.
        View in: PubMed
      35. Matta H, Hozayev B, Tomar R, Chugh P, Chaudhary P. Use of lentiviral vectors for delivery of small interfering RNA. Cancer Biol Ther. 2003 Mar-Apr; 2(2):206-10. PMID: 12750565.
        View in: PubMed
      36. Shivapurkar N, Reddy J, Matta H, Sathyanarayana UG, Huang CX, Toyooka S, Minna JD, Chaudhary P, Gazdar AF. Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification. Oncogene. 2002 Dec 05; 21(55):8510-4. PMID: 12466971.
        View in: PubMed
      37. Matta H, Eby MT, Gazdar AF, Chaudhary P. Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis. Cancer Biol Ther. 2002 Nov-Dec; 1(6):652-60. PMID: 12642689.
        View in: PubMed
      38. Sun Q, Matta H, Chaudhary P. The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. Blood. 2003 Mar 01; 101(5):1956-61. PMID: 12406869.
        View in: PubMed
      39. Harada K, Toyooka S, Shivapurkar N, Maitra A, Reddy JL, Matta H, Miyajima K, Timmons CF, Tomlinson GE, Mastrangelo D, Hay RJ, Chaudhary P, Gazdar AF. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res. 2002 Oct 15; 62(20):5897-901. PMID: 12384554.
        View in: PubMed
      40. Sinha SK, Zachariah S, Quiñones HI, Shindo M, Chaudhary P. Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. J Biol Chem. 2002 Nov 22; 277(47):44953-61. PMID: 12270937.
        View in: PubMed
      41. Liu L, Eby MT, Rathore N, Sinha SK, Kumar A, Chaudhary P. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem. 2002 Apr 19; 277(16):13745-51. PMID: 11830587.
        View in: PubMed
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