Preet M Chaudhary, MD, PhD

TitleProfessor of Medicine
InstitutionUniversity of Southern California
Address1441 Eastlake Ave.
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 865 3950
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    Other Positions
    TitleBloom Family Chair in Lymphoma Research

    TitleChief, Nohl Division of Hematology and Center For Blood Diseases in The Department of Medicine

    TitleDirector For Bone Marrow Transplant

    Collapse Biography 
    Collapse Awards and Honors
    Leukemia Lymphoma Society2005  - 2008Translational Research Award
    Leukemia Lymphoma Society2008  - 2011Translational Research Award
    Multiple Myeloma Research Foundation2005  - 2006Senior Research Award
    2004American Society for Clinical Investigations
    Leukemia Research Foundation1999  - 2000New Investigator Award
    Howard Hughes Institutes1998  - 2001New Faculty Start-Up Award
    Damon Runyon-Walter Winchell Foundation1995  - 1998Postdoctoral Fellowship
    March of Dimes Birth Defects Foundation1990  - 1992Pre-doctoral Fellowship
    1986Second Prize in Ophthalmology
    1986Gold Medal in Surgery
    1985Second Prize in Pathology
    1984  - 1985Distinctions in Anatomy, Physiology Biochemistry and Pharmacology
    1984Honors in First Professional M.B.B.S
    1981Pre-Medical University Merit Certificate (First Rank in the College)
    1981  - 1986National Talent Search Scholarship

    Collapse Overview 
    Collapse Overview
    Preet M. Chaudhary, M.D., Ph.D. is chief of the Jane Anne Nohl Division of Hematology and Center for the study of Blood Diseases in the Department of Medicine, and coleader of the Molecular Genetics Program at the USC Norris Comprehensive Cancer Center. He is also Professor of Medicine, Ronald H. Bloom Family Chair in Lymphoma Research, and Program Director of the USC/Norris Blood and Marrow Transplant Program.

    As a physician-scientist dedicated to hematologic oncology, Dr. Chaudhary has research interests in several areas of cancer, including AIDS-associated cancers, cancer drug resistance, biology of normal and leukemic hematopoietic stem cells, programmed cell death and cellular signaling. He is also interested in molecularly targeted and cellular therapies for leukemias, lymphomas, multiple myeloma and solid tumors. Current work in Dr. Chaudhary's laboratory is focused on developing novel strategies to improve the outcome of stem cell transplantation and the use of chimeric antigen receptor modified T cells for the treatment of cancer.

    Dr. Chaudhary holds six U.S. patents and has published in some of the top scientific journals, including Cell, Immunity, JNCI, PNAS and Blood. He has served as a peer-reviewer for several national and international cancer research funding agencies and has been elected to the prestigious American Society for Clinical Investigations, an honor society of the top physician-scientists in the country.

    Collapse Research 
    Collapse Research Activities and Funding
    Role of IKK epsilon in KSHV/HHV8 associated malignancies
    NIH/NIDCR R01DE025804Mar 4, 2016 - Feb 28, 2021
    Role: Principal Investigator
    A High Throughput Protein Complementation Assay for Inhibitors of NEMO-K13 Intera
    NIH/NCI R01CA139119Jul 1, 2010 - Jun 30, 2014
    Role: Principal Investigator
    Cell Penetrating Helical Peptide Inhibitors of vFLIP K13
    NIH/NIDCR R01DE019811Jun 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    Small Molecule Inhibitors of K13-Induced NF-kB Activation
    NIH/NINDS R21NS063905Jun 15, 2008 - May 31, 2010
    Role: Principal Investigator
    Role of vFLIP K13 in Bone Marrow Failure Syndrome Associated with Infection by Hu
    NIH/NHLBI R21HL085189May 10, 2007 - Oct 30, 2009
    Role: Principal Investigator
    Role of Arsenic Trioxide in Primary Effusion Lymphoma
    NIH/NCI R01CA124621Dec 1, 2006 - Nov 30, 2012
    Role: Principal Investigator
    Genes in X-linked Ectodermal Dysplasia Receptor
    NIH/NIDCR R01DE015189Apr 1, 2003 - Mar 31, 2008
    Role: Principal Investigator
    Role of orf-K13, an HHV8 Encoded vFLIP, in the Pathogenesis of AIDS-related Malig
    NIH/NCI R01CA085177Jun 1, 2000 - May 31, 2012
    Role: Principal Investigator
    NIH/NIAID R01AI047230Apr 1, 2000 - Mar 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Punwani N, Merin N, Mohrbacher A, Yaghmour G, Sano A, Ramezani L, Chaudhary PM, Ramsingh G. Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia. Leuk Res Rep. 2018; 9:18-20. PMID: 29556468.
      View in: PubMed
    2. Matta H, Gopalakrishnan R, Choi S, Prakash R, Natarajan V, Prins R, Gong S, Chitnis SD, Kahn M, Han X, Chaudhary V, Soni A, Sernas J, Khan P, Wang D, Chaudhary PM. Development and characterization of a novel luciferase based cytotoxicity assay. Sci Rep. 2018 Jan 09; 8(1):199. PMID: 29317736.
      View in: PubMed
    3. Sangabathuni S, Murthy RV, Chaudhary PM, Subramani B, Toraskar S, Kikkeri R. Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish. Sci Rep. 2017 Jun 26; 7(1):4239. PMID: 28652584.
      View in: PubMed
    4. Aldoss I, Douer D, Behrendt CE, Chaudhary P, Mohrbacher A, Vrona J, Pullarkat V. Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic leukemia. Eur J Haematol. 2016 Apr; 96(4):375-80. PMID: 26095294.
      View in: PubMed
    5. Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, Sun F, Waterman M, Chen JJ, Chaudhary PM, Loscalzo J, Crandall E, Zhou XJ. DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. PMID: 24895436; PMCID: PMC4086092.
    6. Tolani B, Matta H, Gopalakrishnan R, Punj V, Chaudhary PM. NEMO is essential for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process. J Virol. 2014 Jun; 88(11):6345-54. PMID: 24672029; PMCID: PMC4093867.
    7. Gopalakrishnan R, Matta H, Chaudhary PM. A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-?B. Clin Cancer Res. 2013 Sep 15; 19(18):5016-26. PMID: 23881928; PMCID: PMC3804723.
    8. Graham C, Matta H, Yang Y, Yi H, Suo Y, Tolani B, Chaudhary PM. Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-?B activation. J Virol. 2013 Feb; 87(4):2242-52. PMID: 23236068; PMCID: PMC3571451.
    9. Punj V, Matta H, Chaudhary PM. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One. 2012; 7(5):e37498. PMID: 22624040; PMCID: PMC3356309.
    10. Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM. Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-?B pathway independent of TRAF6, TAK1 and LUBAC. PLoS One. 2012; 7(5):e36601. PMID: 22590573; PMCID: PMC3348130.
    11. Yang Y, Groshong JS, Matta H, Gopalakrishnan R, Yi H, Chaudhary PM. Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem. 2011 Aug 12; 286(32):27988-97. PMID: 21705340; PMCID: PMC3151044.
    12. Matta H, Gopalakrishnan R, Punj V, Yi H, Suo Y, Chaudhary PM. A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner. J Biol Chem. 2011 Jun 17; 286(24):21555-64. PMID: 21531730; PMCID: PMC3122214.
    13. Ahmad A, Groshong JS, Matta H, Schamus S, Punj V, Robinson LJ, Gill PS, Chaudhary PM. Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice. Cancer Biol Ther. 2010 Nov 15; 10(10):1033-40. PMID: 20818173; PMCID: PMC3047095.
    14. Lee HR, Lee S, Chaudhary PM, Gill P, Jung JU. Immune evasion by Kaposi's sarcoma-associated herpesvirus. Future Microbiol. 2010 Sep; 5(9):1349-65. PMID: 20860481; PMCID: PMC3076960.
    15. Tolstov YL, Arora R, Scudiere SC, Busam K, Chaudhary PM, Chang Y, Moore PS. Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood. 2010 Jun 10; 115(23):4973-4. PMID: 20538816; PMCID: PMC2890166.
    16. Liu R, Gong M, Li X, Zhou Y, Gao W, Tulpule A, Chaudhary PM, Jung J, Gill PS. Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma. Blood. 2010 Jul 15; 116(2):297-305. PMID: 20442363; PMCID: PMC2910613.
    17. Punj V, Matta H, Chaudhary PM. X-linked ectodermal dysplasia receptor is downregulated in breast cancer via promoter methylation. Clin Cancer Res. 2010 Feb 15; 16(4):1140-8. PMID: 20145163; PMCID: PMC2822888.
    18. Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary PM, Jung J, Gill PS. KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood. 2010 Jan 28; 115(4):887-95. PMID: 19965636; PMCID: PMC2815507.
    19. Shuda M, Arora R, Kwun HJ, Feng H, Sarid R, Fernández-Figueras MT, Tolstov Y, Gjoerup O, Mansukhani MM, Swerdlow SH, Chaudhary PM, Kirkwood JM, Nalesnik MA, Kant JA, Weiss LM, Moore PS, Chang Y. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer. 2009 Sep 15; 125(6):1243-9. PMID: 19499546.
      View in: PubMed
    20. Punj V, Matta H, Schamus S, Chaudhary PM. Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells. BMC Med Genomics. 2009 Aug 06; 2:50. PMID: 19660139; PMCID: PMC2732924.
    21. Punj V, Matta H, Schamus S, Yang T, Chang Y, Chaudhary PM. Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. Blood. 2009 May 28; 113(22):5660-8. PMID: 19324905; PMCID: PMC2689059.
    22. Moschos SJ, Chaudhary PM, Kirkwood JM. Resolving "kinks" of chemotherapy in melanoma. J Natl Cancer Inst. 2008 Jun 18; 100(12):833-5. PMID: 18544737.
      View in: PubMed
    23. Lu G, Punj V, Chaudhary PM. Proteasome inhibitor Bortezomib induces cell cycle arrest and apoptosis in cell lines derived from Ewing's sarcoma family of tumors and synergizes with TRAIL. Cancer Biol Ther. 2008 Apr; 7(4):603-8. PMID: 18223318.
      View in: PubMed
    24. Lacoste V, Nicot C, Gessain A, Valensi F, Gabarre J, Matta H, Chaudhary PM, Mahieux R. In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v-GPCR become involved during the lytic cycle. Br J Haematol. 2007 Aug; 138(4):487-501. PMID: 17659053.
      View in: PubMed
    25. Matta H, Mazzacurati L, Schamus S, Yang T, Sun Q, Chaudhary PM. Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation. J Biol Chem. 2007 Aug 24; 282(34):24858-65. PMID: 17597077.
      View in: PubMed
    26. Chugh P, Matta H, Schamus S, Zachariah S, Kumar A, Richardson JA, Smith AL, Chaudhary PM. Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12885-90. PMID: 16120683; PMCID: PMC1200255.
    27. Sun Q, Matta H, Chaudhary PM. Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat. Retrovirology. 2005 Feb 15; 2:9. PMID: 15713234; PMCID: PMC554086.
    28. Matta H, Chaudhary PM. The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer Biol Ther. 2005 Jan; 4(1):77-82. PMID: 15662128.
      View in: PubMed
    29. Rathore N, Matta H, Chaudhary PM. An evolutionary conserved pathway of nuclear factor-kappaB activation involving caspase-mediated cleavage and N-end rule pathway-mediated degradation of IkappaBalpha. J Biol Chem. 2004 Sep 17; 279(38):39358-65. PMID: 15252032.
      View in: PubMed
    30. Matta H, Chaudhary PM. Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP). Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9399-404. PMID: 15190178; PMCID: PMC438988.
    31. Shivapurkar N, Toyooka S, Toyooka KO, Reddy J, Miyajima K, Suzuki M, Shigematsu H, Takahashi T, Parikh G, Pass HI, Chaudhary PM, Gazdar AF. Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types. Int J Cancer. 2004 May 01; 109(5):786-92. PMID: 14999791.
      View in: PubMed
    32. Shindo M, Chaudhary PM. The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation. Biochem Biophys Res Commun. 2004 Feb 27; 315(1):73-8. PMID: 15013427.
      View in: PubMed
    33. Sun Q, Zachariah S, Chaudhary PM. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem. 2003 Dec 26; 278(52):52437-45. PMID: 14563855.
      View in: PubMed
    34. Matta H, Sun Q, Moses G, Chaudhary PM. Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation. J Biol Chem. 2003 Dec 26; 278(52):52406-11. PMID: 14561765.
      View in: PubMed
    35. Tomar RS, Matta H, Chaudhary PM. Use of adeno-associated viral vector for delivery of small interfering RNA. Oncogene. 2003 Aug 28; 22(36):5712-5. PMID: 12944921.
      View in: PubMed
    36. Kauppila S, Maaty WS, Chen P, Tomar RS, Eby MT, Chapo J, Chew S, Rathore N, Zachariah S, Sinha SK, Abrams JM, Chaudhary PM. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Oncogene. 2003 Jul 31; 22(31):4860-7. PMID: 12894227.
      View in: PubMed
    37. Matta H, Hozayev B, Tomar R, Chugh P, Chaudhary PM. Use of lentiviral vectors for delivery of small interfering RNA. Cancer Biol Ther. 2003 Mar-Apr; 2(2):206-10. PMID: 12750565.
      View in: PubMed
    38. Shivapurkar N, Reddy J, Matta H, Sathyanarayana UG, Huang CX, Toyooka S, Minna JD, Chaudhary PM, Gazdar AF. Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification. Oncogene. 2002 Dec 05; 21(55):8510-4. PMID: 12466971.
      View in: PubMed
    39. Matta H, Eby MT, Gazdar AF, Chaudhary PM. Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis. Cancer Biol Ther. 2002 Nov-Dec; 1(6):652-60. PMID: 12642689.
      View in: PubMed
    40. Sun Q, Matta H, Chaudhary PM. The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. Blood. 2003 Mar 01; 101(5):1956-61. PMID: 12406869.
      View in: PubMed
    41. Harada K, Toyooka S, Shivapurkar N, Maitra A, Reddy JL, Matta H, Miyajima K, Timmons CF, Tomlinson GE, Mastrangelo D, Hay RJ, Chaudhary PM, Gazdar AF. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res. 2002 Oct 15; 62(20):5897-901. PMID: 12384554.
      View in: PubMed
    42. Sinha SK, Zachariah S, Quiñones HI, Shindo M, Chaudhary PM. Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. J Biol Chem. 2002 Nov 22; 277(47):44953-61. PMID: 12270937.
      View in: PubMed
    43. Liu L, Eby MT, Rathore N, Sinha SK, Kumar A, Chaudhary PM. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem. 2002 Apr 19; 277(16):13745-51. PMID: 11830587.
      View in: PubMed
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