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Hittu Matta, PhD

Title(s)Assistant Professor of Research Medicine
Address1450 Biggy St. NRT3513
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 865 3950
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    Dr. Matta earned her Master's and PhD in Microbiology followed by a fellowship at The Hamon Center for Therapeutic and Oncology Research, University of Texas Southwestern Medical Center.

    Dr. Matta's research interests include KSHV-associated malignancies and drug development.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma. Sci Rep. 2020 Mar 31; 10(1):5712. Gopalakrishnan R, Matta H, Choi S, Chaudhary PM. PMID: 32235878.
      View in: PubMed   Mentions:    Fields:    
    2. A Fast and Sensitive Luciferase-based Assay for Antibody Engineering and Design of Chimeric Antigen Receptors. Sci Rep. 2020 02 11; 10(1):2318. Natarajan V, Gopalakrishnan R, Matta H, Choi S, Gong S, Jeronimo A, Keerthipati PS, Morales A, Venkatesh H, Chaudhary PM. PMID: 32047180.
      View in: PubMed   Mentions:    Fields:    
    3. A novel luciferase-based assay for the detection of Chimeric Antigen Receptors. Sci Rep. 2019 02 13; 9(1):1957. Gopalakrishnan R, Matta H, Choi S, Natarajan V, Prins R, Gong S, Zenunovic A, Narasappa N, Patel F, Prakash R, Chaudhary V, Sikri V, Chitnis SD, Kochegarov A, Wang D, Falat M, Kahn M, Keerthipati PS, Sharma N, Lenka J, Stieben TM, Braun J, Batra A, Purvis K, Ito K, Lee JH, Jeronimo A, Zamora HM, Membreno A, Qiu Q, Peshin S, Namburu L, Chaudhary PM. PMID: 30760795.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Development and characterization of a novel luciferase based cytotoxicity assay. Sci Rep. 2018 01 09; 8(1):199. Matta H, Gopalakrishnan R, Choi S, Prakash R, Natarajan V, Prins R, Gong S, Chitnis SD, Kahn M, Han X, Chaudhary V, Soni A, Sernas J, Khan P, Wang D, Chaudhary PM. PMID: 29317736.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene. 2016 Apr 07; 35(14):1797-810. Gopalakrishnan R, Matta H, Tolani B, Triche T, Chaudhary PM. PMID: 26119939.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    6. NEMO is essential for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process. J Virol. 2014 Jun; 88(11):6345-54. Tolani B, Matta H, Gopalakrishnan R, Punj V, Chaudhary PM. PMID: 24672029.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    7. A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-?B. Clin Cancer Res. 2013 Sep 15; 19(18):5016-26. Gopalakrishnan R, Matta H, Chaudhary PM. PMID: 23881928.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    8. Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene. 2014 May 29; 33(22):2928-37. Tolani B, Gopalakrishnan R, Punj V, Matta H, Chaudhary PM. PMID: 23792448.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    9. Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-?B activation. J Virol. 2013 Feb; 87(4):2242-52. Graham C, Matta H, Yang Y, Yi H, Suo Y, Tolani B, Chaudhary PM. PMID: 23236068.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One. 2012; 7(5):e37498. Punj V, Matta H, Chaudhary PM. PMID: 22624040.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-?B pathway independent of TRAF6, TAK1 and LUBAC. PLoS One. 2012; 7(5):e36601. Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM. PMID: 22590573.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem. 2011 Aug 12; 286(32):27988-97. Yang Y, Groshong JS, Matta H, Gopalakrishnan R, Yi H, Chaudhary PM. PMID: 21705340.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner. J Biol Chem. 2011 Jun 17; 286(24):21555-64. Matta H, Gopalakrishnan R, Punj V, Yi H, Suo Y, Chaudhary PM. PMID: 21531730.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice. Cancer Biol Ther. 2010 Nov 15; 10(10):1033-40. Ahmad A, Groshong JS, Matta H, Schamus S, Punj V, Robinson LJ, Gill PS, Chaudhary PM. PMID: 20818173.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. X-linked ectodermal dysplasia receptor is downregulated in breast cancer via promoter methylation. Clin Cancer Res. 2010 Feb 15; 16(4):1140-8. Punj V, Matta H, Chaudhary PM. PMID: 20145163.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells. BMC Med Genomics. 2009 Aug 06; 2:50. Punj V, Matta H, Schamus S, Chaudhary PM. PMID: 19660139.
      View in: PubMed   Mentions: 15     Fields:    
    17. Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. Blood. 2009 May 28; 113(22):5660-8. Punj V, Matta H, Schamus S, Yang T, Chang Y, Chaudhary PM. PMID: 19324905.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    18. K13 blocks KSHV lytic replication and deregulates vIL6 and hIL6 expression: a model of lytic replication induced clonal selection in viral oncogenesis. PLoS One. 2007 Oct 24; 2(10):e1067. Zhao J, Punj V, Matta H, Mazzacurati L, Schamus S, Yang Y, Yang T, Hong Y, Chaudhary PM. PMID: 17957251.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    19. In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v-GPCR become involved during the lytic cycle. Br J Haematol. 2007 Aug; 138(4):487-501. Lacoste V, Nicot C, Gessain A, Valensi F, Gabarre J, Matta H, Chaudhary PM, Mahieux R. PMID: 17659053.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation. J Biol Chem. 2007 Aug 24; 282(34):24858-65. Matta H, Mazzacurati L, Schamus S, Yang T, Sun Q, Chaudhary PM. PMID: 17597077.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    21. Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12885-90. Chugh P, Matta H, Schamus S, Zachariah S, Kumar A, Richardson JA, Smith AL, Chaudhary PM. PMID: 16120683.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    22. Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat. Retrovirology. 2005 Feb 15; 2:9. Sun Q, Matta H, Chaudhary PM. PMID: 15713234.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer Biol Ther. 2005 Jan; 4(1):77-82. Matta H, Chaudhary PM. PMID: 15662128.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    24. An evolutionary conserved pathway of nuclear factor-kappaB activation involving caspase-mediated cleavage and N-end rule pathway-mediated degradation of IkappaBalpha. J Biol Chem. 2004 Sep 17; 279(38):39358-65. Rathore N, Matta H, Chaudhary PM. PMID: 15252032.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    25. Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP). Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9399-404. Matta H, Chaudhary PM. PMID: 15190178.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    26. Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation. J Biol Chem. 2003 Dec 26; 278(52):52406-11. Matta H, Sun Q, Moses G, Chaudhary PM. PMID: 14561765.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    27. Use of adeno-associated viral vector for delivery of small interfering RNA. Oncogene. 2003 Aug 28; 22(36):5712-5. Tomar RS, Matta H, Chaudhary PM. PMID: 12944921.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    28. Use of lentiviral vectors for delivery of small interfering RNA. Cancer Biol Ther. 2003 Mar-Apr; 2(2):206-10. Matta H, Hozayev B, Tomar R, Chugh P, Chaudhary PM. PMID: 12750565.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    29. Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification. Oncogene. 2002 Dec 05; 21(55):8510-4. Shivapurkar N, Reddy J, Matta H, Sathyanarayana UG, Huang CX, Toyooka S, Minna JD, Chaudhary PM, Gazdar AF. PMID: 12466971.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    30. Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis. Cancer Biol Ther. 2002 Nov-Dec; 1(6):652-60. Matta H, Eby MT, Gazdar AF, Chaudhary PM. PMID: 12642689.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. Blood. 2003 Mar 01; 101(5):1956-61. Sun Q, Matta H, Chaudhary PM. PMID: 12406869.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    32. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res. 2002 Oct 15; 62(20):5897-901. Harada K, Toyooka S, Shivapurkar N, Maitra A, Reddy JL, Matta H, Miyajima K, Timmons CF, Tomlinson GE, Mastrangelo D, Hay RJ, Chaudhary PM, Gazdar AF. PMID: 12384554.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
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