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Daniel George Arkfeld, MD

Title(s)Professor of Clinical Medicine
Phone+1 323 442 1946
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    Collapse Biography 
    Collapse Awards and Honors
    American College of Rheumatology2013Mentor Award
    American College of Rheumatology2009Mentor Award
    American College of Rheumatology2007Mentor Award
    University of Southern California1999Second Year Medical Student Teaching Award

    Collapse Overview 
    Collapse Overview
    A Los Angeles native, Dr. Arkfeld, first joined the Keck School of Medicine faculty in 1994 after completing a fellowship at Cedars-Sinai Medical Center in West LA. Prior to his current administrative position as Director of Rheumatology Education, Dr. Arkfeld was Chief of Rheumatology Clinic at LAC+USC Medical Center.

    Dr. Arkfeld's major areas of research interests include rheumatoid arthritis, fibromyalgia, osteoporosis and osteoarthritis. In addition to being a renowned lecturer, having spoken all across the globe, Dr. Arkfeld is also a former little league baseball coach and is currently the doctor for the USC Women’s Basketball Team.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Edman MC, Janga SR, Meng Z, Bechtold M, Chen AF, Kim C, Naman L, Sarma A, Teekappanavar N, Kim AY, Madrigal S, Singh S, Ortiz E, Christianakis S, Arkfeld DG, Mack WJ, Heur M, Stohl W, Hamm-Alvarez SF. Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients. Sci Rep. 2018 Jul 23; 8(1):11044. PMID: 30038391.
      View in: PubMed
    2. Metyas S, Chen CL, Yeter K, Solyman J, Arkfeld DG. Low Dose Naltrexone in the Treatment of Fibromyalgia. Curr Rheumatol Rev. 2018; 14(2):177-180. PMID: 28325149.
      View in: PubMed
    3. Metyas S, Rezk T, Arkfeld D, Leptich T. Autoinflammation and Immunomodulation in Inflammatory Fibromyalgia Syndrome- A Review. Curr Rheumatol Rev. 2017; 13(2):98-102. PMID: 27655626.
      View in: PubMed
    4. Johnson JA, Yu SS, Elist M, Arkfeld D, Panush RS. Rheumatologic manifestations of the "MonoMAC" syndrome. a systematic review. Clin Rheumatol. 2015 Sep; 34(9):1643-5. PMID: 25739845.
      View in: PubMed
    5. Kreitenberg AJ, Ortiz EC, Arkfeld DG. Priapism after tumor necrosis factor alpha inhibitor use. Clin Rheumatol. 2015 Apr; 34(4):801-2. PMID: 25579651.
      View in: PubMed
    6. Metyas SK, Solyman JS, Arkfeld DG. Inflammatory Fibromyalgia: Is it Real? Curr Rheumatol Rev. 2015; 11(1):15-17. PMID: 26002453.
      View in: PubMed
    7. Escalante P, Kooda KJ, Khan R, Aye SS, Christianakis S, Arkfeld DG, Ehresmann GR, Kort JJ, Jones BE. Diagnosis of latent tuberculosis infection with T-SPOT(®).TB in a predominantly immigrant population with rheumatologic disorders. Lung. 2015 Feb; 193(1):3-11. PMID: 25318864.
      View in: PubMed
    8. Hamm-Alvarez SF, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W. Tear cathepsin S as a candidate biomarker for Sjögren's syndrome. Arthritis Rheumatol. 2014 Jul; 66(7):1872-81. PMID: 24644101.
      View in: PubMed
    9. Metyas S, Ibrahim M, Solyman J, Yeter KC, Arkfeld DG. Giant cell arteritis with visual loss following zoledronic acid infusion. Int J Rheum Dis. 2014 Jan; 17(1):113-5. PMID: 24472274.
      View in: PubMed
    10. Metyas S, Tawadrous M, Yeter KC, Arkfeld DG. Neurosarcoidosis mimicking multiple sclerosis successfully treated with methotrexate and adalimumab. Int J Rheum Dis. 2014 Feb; 17(2):214-6. PMID: 24576278.
      View in: PubMed
    11. Yeter KC, Ortiz EC, Arkfeld DG. Reversal of chronic refractory tophaceous gout with erosions with pegloticase. Int J Rheum Dis. 2013 Jun; 16(3):369-70. PMID: 23981765.
      View in: PubMed
    12. Yeter KC, Arkfeld DG. Treatment of multicentric reticulohistiocytosis with adalimumab, minocycline, methotrexate. Int J Rheum Dis. 2013 Feb; 16(1):105-6. PMID: 23441782.
      View in: PubMed
    13. Yang D, Arkfeld D, Fong TL. Development of anti-CCP-positive rheumatoid arthritis following pegylated interferon-a2a treatment for chronic hepatitis C infection. J Rheumatol. 2010 Aug 01; 37(8):1777. PMID: 20675854.
      View in: PubMed
    14. Metyas S, Rouman H, Arkfeld DG. Pregnancy in a patient with gouty arthritis secondary to pseudo-Bartter syndrome. J Clin Rheumatol. 2010 Aug; 16(5):219-20. PMID: 20661067.
      View in: PubMed
    15. Arkfeld DG, Weitz IC. Immune thrombocytopenia in patients with connective tissue disorders and the antiphospholipid antibody syndrome. Hematol Oncol Clin North Am. 2009 Dec; 23(6):1239-49. PMID: 19932431.
      View in: PubMed
    16. Lacson SM, Bradley C, Arkfeld DG. Facebook medicine. J Rheumatol. 2009 Jan; 36(1):211. PMID: 19208543.
      View in: PubMed
    17. Metyas SK, Tadros RM, Arkfeld DG. Adalimumab-induced noncaseating granuloma in the bone marrow of a patient being treated for rheumatoid arthritis. Rheumatol Int. 2009 Feb; 29(4):437-9. PMID: 18762943.
      View in: PubMed
    18. Arkfeld DG. Higher gonorrhea rates among African Americans than among White persons in the United States. Ann Intern Med. 2008 Mar 18; 148(6):482; author reply 482. PMID: 18347355.
      View in: PubMed
    19. Arkfeld DG. Biological significance of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis. Ann Intern Med. 2008 Mar 04; 148(5):403; author reply 403-4. PMID: 18316759.
      View in: PubMed
    20. Arkfeld DG. How is infliximab harmful? Ann Intern Med. 2008 Jan 15; 148(2):166; author reply 166. PMID: 18195344.
      View in: PubMed
    21. Metyas S, La D, Arkfeld DG. The use of the tumour necrosis factor antagonist infliximab in heart transplant recipients: two case reports. Ann Rheum Dis. 2007 Nov; 66(11):1544-5. PMID: 17934084.
      View in: PubMed
    22. Arkfeld DG. The potential utility of B cell-directed biologic therapy in autoimmune diseases. Rheumatol Int. 2008 Jan; 28(3):205-15. PMID: 17957371.
      View in: PubMed
    23. Oliveira B, Arkfeld DG, Weitz IC, Shinada S, Ehresmann G. Successful rituximab therapy of acquired factor VIII inhibitor in a patient with rheumatoid arthritis. J Clin Rheumatol. 2007 Apr; 13(2):89-91. PMID: 17414538.
      View in: PubMed
    24. Rubenstein E, Arkfeld DG, Metyas S, Shinada S, Ehresmann S, Liebman HA. Rituximab treatment for resistant antiphospholipid syndrome. J Rheumatol. 2006 Feb; 33(2):355-7. PMID: 16465669.
      View in: PubMed
    25. Hendifar AE, Johnson D, Arkfeld DG. Myositis ossificans: a case report. Arthritis Rheum. 2005 Oct 15; 53(5):793-5. PMID: 16208662.
      View in: PubMed
    26. Lacson SM, Metyas SK, Arkfeld DG. Hip arthroplasty in a 101-year-old patient. J Clin Rheumatol. 2005 Jun; 11(3):180. PMID: 16357745.
      View in: PubMed
    27. Arkfeld DG, Rubenstein E. Quest for the Holy Grail to cure arthritis and osteoporosis: emphasis on bone drug delivery systems. Adv Drug Deliv Rev. 2005 May 25; 57(7):939-44. PMID: 15876396.
      View in: PubMed
    28. Oh J, Arkfeld DG, Horwitz DA. Development of Crohn's disease in a patient taking etanercept. J Rheumatol. 2005 Apr; 32(4):752-3. PMID: 15801037.
      View in: PubMed
    29. Rubenstein EJ, Arkfeld DG. Adult Still's disease in a 75-year-old patient. J Am Geriatr Soc. 2004 Dec; 52(12):2144-5. PMID: 15571562.
      View in: PubMed
    30. Metyas S, Arkfeld DG, Forrester DM, Ehresmann GR. Infliximab treatment of Familial Mediterranean fever and its effect on secondary AA amyloidosis. J Clin Rheumatol. 2004 Jun; 10(3):134-7. PMID: 17043487.
      View in: PubMed
    31. Tan SM, Xu D, Roschke V, Perry JW, Arkfeld DG, Ehresmann GR, Migone TS, Hilbert DM, Stohl W. Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis. Arthritis Rheum. 2003 Apr; 48(4):982-92. PMID: 12687540.
      View in: PubMed
    32. Tsark EC, Wang W, Teng YC, Arkfeld D, Dodge GR, Kovats S. Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophages. J Immunol. 2002 Dec 01; 169(11):6625-33. PMID: 12444176.
      View in: PubMed
    33. Moreland LW, Schiff MH, Baumgartner SW, Tindall EA, Fleischmann RM, Bulpitt KJ, Weaver AL, Keystone EC, Furst DE, Mease PJ, Ruderman EM, Horwitz DA, Arkfeld DG, Garrison L, Burge DJ, Blosch CM, Lange ML, McDonnell ND, Weinblatt ME. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann Intern Med. 1999 Mar 16; 130(6):478-86. PMID: 10075615.
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    34. Stohl W, Arkfeld DG. Treatment of rheumatoid arthritis. N Engl J Med. 1996 Sep 12; 335(11):821-2; author reply 822-3. PMID: 8778593.
      View in: PubMed
    35. Liebling MR, Arkfeld DG, Michelini GA, Nishio MJ, Eng BJ, Jin T, Louie JS. Identification of Neisseria gonorrhoeae in synovial fluid using the polymerase chain reaction. Arthritis Rheum. 1994 May; 37(5):702-9. PMID: 8185697.
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