Daniel George Arkfeld, MD

Title(s)Professor of Clinical Medicine
SchoolKeck School of Medicine of Usc
Address1520 San Pablo St. Bldg#287
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1946
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    Collapse Biography 
    Collapse education and training
    UCLA, Los AngelesMD06/1986MEDICINE
    Cedars-Sinai, Los AngelesMD06/1989Internal Medicine
    Harbor-UCLA, CarsonMD06/1991Rheumatology
    Collapse awards and honors
    American College of Rheumatology2013Mentor Award
    American College of Rheumatology2009Mentor Award
    American College of Rheumatology2007Mentor Award
    University of Southern California1999Second Year Medical Student Teaching Award

    Collapse Overview 
    Collapse overview
    A Los Angeles native, Dr. Arkfeld, first joined the Keck School of Medicine faculty in 1994 after completing a fellowship at Cedars-Sinai Medical Center in West LA. Prior to his current administrative position as Director of Rheumatology CME Educational courses, Dr. Arkfeld was Chief of Rheumatology Clinic at LAC+USC Medical Center.

    As a cliniccal professor, Dr. Arkfeld's major areas of research interests include rheumatoid arthritis, fibromyalgia, and Sjogren's Syndrome. In addition to being a renowned lecturer, having spoken all across the globe, Dr. Arkfeld is also a former little league baseball coach and doctor for the USC Women’s Basketball Team.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rituximab Induced Flare of Psoriatic Arthritis in a Patient with Devic's Syndrome: A Case Report. Curr Rheumatol Rev. 2025; 21(1):109-112. Gonzales SAB, Mortezaei K, Arkfeld DG. PMID: 38425114.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. A Rare Presentation of Cryoglobulinemic Vasculitis Associated with Primary Sjögren's Syndrome. Curr Rheumatol Rev. 2024 Sep 11. Metyas C, Lee JD, Jun JA, Arkfeld DG. PMID: 39313873.
      View in: PubMed   Mentions:    Fields:    
    3. The Effect of Low-Dose Glucocorticoids Over Two Years on Weight and Blood Pressure in Rheumatoid Arthritis. Ann Intern Med. 2024 04; 177(4):545. Arkfeld D, Gonzales SAB, Ruddy K. PMID: 38621264.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Potential Benefits of Psilocybin for Lupus Pain: A Case Report. Curr Rheumatol Rev. 2024; 20(1):97-99. Arkfeld DG, Alexopoulos C, Gonzales SAB. PMID: 37670693.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Clinical Image: Eczema herpeticum in a patient with rheumatoid arthritis and dry eye syndrome. ACR Open Rheumatol. 2024 Mar; 6(3):137. Mortezaei K, Gonzales SAB, Arkfeld DG. PMID: 38148274; PMCID: PMC10933631.
      View in: PubMed   Mentions:
    6. Arteritic Anterior Ischemic Optic Neuropathy and Central Retinal Artery Occlusion in Polyarteritis Nodosa. J Neuroophthalmol. 2024 Sep 01; 44(3):e332-e333. Peng MG, Zukin LM, Wallace WD, Sibug Saber ME, Arkfeld DG, Chang JR. PMID: 37335682.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. The time to offer treatments for COVID-19. Expert Opin Investig Drugs. 2021 May; 30(5):505-518. Ngo BT, Marik P, Kory P, Shapiro L, Thomadsen R, Iglesias J, Ditmore S, Rendell M, Varon J, Dubé M, Nanda N, In G, Arkfeld D, Chaudhary P, Campese VM, Hanna DL, Sawcer DE, Ehresmann G, Peng D, Smogorewski M, Armstrong A, Dasgupta R, Sattler F, Brennan-Rieder D, Mussini C, Mitja O, Soriano V, Peschanski N, Hayem G, Confalonieri M, Piccirillo MC, Lobo-Ferreira A, Bello Rivero I, Turkia M, Vinjevoll EH, Griffin D, Hung IF. PMID: 33721548; PMCID: PMC8074648.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    8. The Importance of Understanding the Stages of COVID-19 in Treatment and Trials. AIDS Rev. 2021 02 08; 23(1):40-47. Griffin DO, Brennan-Rieder D, Ngo B, Kory P, Confalonieri M, Shapiro L, Iglesias J, Dube M, Nanda N, In GK, Arkfeld D, Chaudhary P, Campese VM, Hanna DL, Sawcer D, Ehresmann G, Peng D, Smorgorzewski M, Amstrong A, Vinjevoll EH, Dasgupta R, Sattler FR, Mussini C, Mitjà O, Soriano V, Peschanski N, Hayem G, Piccirillo MC, Lobo-Ferreira A, Rivero IB, Hung IFH, Rendell M, Ditmore S, Varon J, Marik P. PMID: 33556957.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    9. A patient with primary Sjogren's syndrome, cystic lung disease, and MALT lymphoma treated successfully with rituximab: a case-based review. Clin Rheumatol. 2020 Apr; 39(4):1357-1362. Wise LM, Arkfeld DG. PMID: 31863212.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients. Sci Rep. 2018 07 23; 8(1):11044. Edman MC, Janga SR, Meng Z, Bechtold M, Chen AF, Kim C, Naman L, Sarma A, Teekappanavar N, Kim AY, Madrigal S, Singh S, Ortiz E, Christianakis S, Arkfeld DG, Mack WJ, Heur M, Stohl W, Hamm-Alvarez SF. PMID: 30038391; PMCID: PMC6056496.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    11. Low Dose Naltrexone in the Treatment of Fibromyalgia. Curr Rheumatol Rev. 2018; 14(2):177-180. Metyas S, Chen CL, Yeter K, Solyman J, Arkfeld DG. PMID: 28325149.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    12. Autoinflammation and Immunomodulation in Inflammatory Fibromyalgia Syndrome- A Review. Curr Rheumatol Rev. 2017; 13(2):98-102. Metyas S, Rezk T, Arkfeld D, Leptich T. PMID: 27655626.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    13. Rheumatologic manifestations of the "MonoMAC" syndrome. a systematic review. Clin Rheumatol. 2015 Sep; 34(9):1643-5. Johnson JA, Yu SS, Elist M, Arkfeld D, Panush RS. PMID: 25739845.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Priapism after tumor necrosis factor alpha inhibitor use. Clin Rheumatol. 2015 Apr; 34(4):801-2. Kreitenberg AJ, Ortiz EC, Arkfeld DG. PMID: 25579651.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Inflammatory Fibromyalgia: Is it Real? Curr Rheumatol Rev. 2015; 11(1):15-17. Metyas SK, Solyman JS, Arkfeld DG. PMID: 26002453.
      View in: PubMed   Mentions: 5     Fields:    
    16. Diagnosis of latent tuberculosis infection with T-SPOT(®).TB in a predominantly immigrant population with rheumatologic disorders. Lung. 2015 Feb; 193(1):3-11. Escalante P, Kooda KJ, Khan R, Aye SS, Christianakis S, Arkfeld DG, Ehresmann GR, Kort JJ, Jones BE. PMID: 25318864.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Tear cathepsin S as a candidate biomarker for Sjögren's syndrome. Arthritis Rheumatol. 2014 Jul; 66(7):1872-81. Hamm-Alvarez SF, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W. PMID: 24644101; PMCID: PMC4077975.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    18. Giant cell arteritis with visual loss following zoledronic acid infusion. Int J Rheum Dis. 2014 Jan; 17(1):113-5. Metyas S, Ibrahim M, Solyman J, Yeter KC, Arkfeld DG. PMID: 24472274.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Neurosarcoidosis mimicking multiple sclerosis successfully treated with methotrexate and adalimumab. Int J Rheum Dis. 2014 Feb; 17(2):214-6. Metyas S, Tawadrous M, Yeter KC, Arkfeld DG. PMID: 24576278.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. Reversal of chronic refractory tophaceous gout with erosions with pegloticase. Int J Rheum Dis. 2013 Jun; 16(3):369-70. Yeter KC, Ortiz EC, Arkfeld DG. PMID: 23981765.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Treatment of multicentric reticulohistiocytosis with adalimumab, minocycline, methotrexate. Int J Rheum Dis. 2013 Feb; 16(1):105-6. Yeter KC, Arkfeld DG. PMID: 23441782.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Development of anti-CCP-positive rheumatoid arthritis following pegylated interferon-α2a treatment for chronic hepatitis C infection. J Rheumatol. 2010 Aug 01; 37(8):1777. Yang D, Arkfeld D, Fong TL. PMID: 20675854.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Pregnancy in a patient with gouty arthritis secondary to pseudo-Bartter syndrome. J Clin Rheumatol. 2010 Aug; 16(5):219-20. Metyas S, Rouman H, Arkfeld DG. PMID: 20661067.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Immune thrombocytopenia in patients with connective tissue disorders and the antiphospholipid antibody syndrome. Hematol Oncol Clin North Am. 2009 Dec; 23(6):1239-49. Arkfeld DG, Weitz IC. PMID: 19932431.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    25. Facebook medicine. J Rheumatol. 2009 Jan; 36(1):211. Lacson SM, Bradley C, Arkfeld DG. PMID: 19208543.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Adalimumab-induced noncaseating granuloma in the bone marrow of a patient being treated for rheumatoid arthritis. Rheumatol Int. 2009 Feb; 29(4):437-9. Metyas SK, Tadros RM, Arkfeld DG. PMID: 18762943.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    27. Higher gonorrhea rates among African Americans than among White persons in the United States. Ann Intern Med. 2008 Mar 18; 148(6):482; author reply 482. Arkfeld DG. PMID: 18347355.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. Biological significance of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis. Ann Intern Med. 2008 Mar 04; 148(5):403; author reply 403-4. Arkfeld DG. PMID: 18316759.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. How is infliximab harmful? Ann Intern Med. 2008 Jan 15; 148(2):166; author reply 166. Arkfeld DG. PMID: 18195344.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. The use of the tumour necrosis factor antagonist infliximab in heart transplant recipients: two case reports. Ann Rheum Dis. 2007 Nov; 66(11):1544-5. Metyas S, La D, Arkfeld DG. PMID: 17934084; PMCID: PMC2111643.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. The potential utility of B cell-directed biologic therapy in autoimmune diseases. Rheumatol Int. 2008 Jan; 28(3):205-15. Arkfeld DG. PMID: 17957371; PMCID: PMC2134974.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    32. Successful rituximab therapy of acquired factor VIII inhibitor in a patient with rheumatoid arthritis. J Clin Rheumatol. 2007 Apr; 13(2):89-91. Oliveira B, Arkfeld DG, Weitz IC, Shinada S, Ehresmann G. PMID: 17414538.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    33. Rituximab treatment for resistant antiphospholipid syndrome. J Rheumatol. 2006 Feb; 33(2):355-7. Rubenstein E, Arkfeld DG, Metyas S, Shinada S, Ehresmann S, Liebman HA. PMID: 16465669.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    34. Myositis ossificans: a case report. Arthritis Rheum. 2005 Oct 15; 53(5):793-5. Hendifar AE, Johnson D, Arkfeld DG. PMID: 16208662.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    35. Hip arthroplasty in a 101-year-old patient. J Clin Rheumatol. 2005 Jun; 11(3):180. Lacson SM, Metyas SK, Arkfeld DG. PMID: 16357745.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Quest for the Holy Grail to cure arthritis and osteoporosis: emphasis on bone drug delivery systems. Adv Drug Deliv Rev. 2005 May 25; 57(7):939-44. Arkfeld DG, Rubenstein E. PMID: 15876396.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. Development of Crohn's disease in a patient taking etanercept. J Rheumatol. 2005 Apr; 32(4):752-3. Oh J, Arkfeld DG, Horwitz DA. PMID: 15801037.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    38. Adult Still's disease in a 75-year-old patient. J Am Geriatr Soc. 2004 Dec; 52(12):2144-5. Rubenstein EJ, Arkfeld DG. PMID: 15571562.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. Infliximab treatment of Familial Mediterranean fever and its effect on secondary AA amyloidosis. J Clin Rheumatol. 2004 Jun; 10(3):134-7. Metyas S, Arkfeld DG, Forrester DM, Ehresmann GR. PMID: 17043487.
      View in: PubMed   Mentions: 13     Fields:    
    40. Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis. Arthritis Rheum. 2003 Apr; 48(4):982-92. Tan SM, Xu D, Roschke V, Perry JW, Arkfeld DG, Ehresmann GR, Migone TS, Hilbert DM, Stohl W. PMID: 12687540.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    41. Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophages. J Immunol. 2002 Dec 01; 169(11):6625-33. Tsark EC, Wang W, Teng YC, Arkfeld D, Dodge GR, Kovats S. PMID: 12444176.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    42. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann Intern Med. 1999 Mar 16; 130(6):478-86. Moreland LW, Schiff MH, Baumgartner SW, Tindall EA, Fleischmann RM, Bulpitt KJ, Weaver AL, Keystone EC, Furst DE, Mease PJ, Ruderman EM, Horwitz DA, Arkfeld DG, Garrison L, Burge DJ, Blosch CM, Lange ML, McDonnell ND, Weinblatt ME. PMID: 10075615.
      View in: PubMed   Mentions: 314     Fields:    Translation:HumansCTClinical Trials
    43. Treatment of rheumatoid arthritis. N Engl J Med. 1996 Sep 12; 335(11):821-2; author reply 822-3. Stohl W, Arkfeld DG. PMID: 8778593.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Identification of Neisseria gonorrhoeae in synovial fluid using the polymerase chain reaction. Arthritis Rheum. 1994 May; 37(5):702-9. Liebling MR, Arkfeld DG, Michelini GA, Nishio MJ, Eng BJ, Jin T, Louie JS. PMID: 8185697.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
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