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Long-term efficacy and safety of continued complement C1s inhibition with sutimlimab in cold agglutinin disease: CADENZA study Part B. EClinicalMedicine. 2024 Aug; 74:102733.
Röth A, Berentsen S, Barcellini W, D'Sa S, Jilma B, Michel M, Weitz IC, Yamaguchi M, Nishimura JI, Vos JMI, Cid J, Storek M, Wong N, Yoo R, Jayawardene D, Srivastava S, Wardecki M, Shafer F, Lee M, Broome CM. PMID: 39091672; PMCID: PMC11293518.
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PubMed Mentions:
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Sustained improvements in patient-reported outcomes after long-term sutimlimab in patients with cold agglutinin disease: results from the CADENZA study open-label extension. EClinicalMedicine. 2024 Aug; 74:102732.
Röth A, Broome CM, Barcellini W, Jilma B, Hill QA, Cella D, Anderson Tvedt TH, Yamaguchi M, Murakhovskaya I, Lee M, Shafer F, Wardecki M, Jayawardene D, Yoo R, Msihid J, Weitz IC. PMID: 39114274; PMCID: PMC11304688.
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PubMed Mentions:
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Correction to: Sutimlimab improves quality of life in patients with cold agglutinin disease: results of patientreported outcomes from the CARDINAL study. Ann Hematol. 2024 May; 103(5):1803.
Röth A, Barcellini W, Anderson Tvedt TH, Miyakawa Y, Kuter DJ, Su J, Jiang X, Hobbs W, Morales J, Shafer F, Weitz IC. PMID: 38519606; PMCID: PMC11009724.
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PubMed Mentions: Fields:
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Long-term sutimlimab improves quality of life for patients with cold agglutinin disease: CARDINAL 2-year follow-up. Blood Adv. 2023 10 10; 7(19):5890-5897.
Röth A, Broome CM, Barcellini W, Tvedt THA, Miyakawa Y, D'Sa S, Cella D, Bozzi S, Jayawardene D, Yoo R, Shafer F, Wardecki M, Weitz IC. PMID: 37459203; PMCID: PMC10558612.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Complement in immune thrombocytopenia (ITP): The role of complement in refractory ITP. Br J Haematol. 2023 10; 203(1):96-100.
Weitz IC, Liebman HA. PMID: 37735550.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Sustained inhibition of complement C1s with sutimlimab over 2 years in patients with cold agglutinin disease. Am J Hematol. 2023 08; 98(8):1246-1253.
Röth A, Barcellini W, D'Sa S, Miyakawa Y, Broome CM, Michel M, Kuter DJ, Jilma B, Tvedt THA, Weitz IC, Yoo R, Jayawardene D, Vagge DS, Kralova K, Shafer F, Ward?cki M, Lee M, Berentsen S. PMID: 37246953.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Pegcetacoplan: A New Opportunity for Complement Inhibition in PNH. J Blood Med. 2023; 14:239-245.
Weitz IC. PMID: 37016661; PMCID: PMC10066888.
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PubMed Mentions:
3
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Biomarkers and laboratory assessments for monitoring the treatment of patients with paroxysmal nocturnal hemoglobinuria: Differences between terminal and proximal complement inhibition. Blood Rev. 2023 05; 59:101041.
Kulasekararaj AG, Kuter DJ, Griffin M, Weitz IC, Röth A. PMID: 36732204.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Sutimlimab provides clinically meaningful improvements in patient-reported outcomes in patients with cold agglutinin disease: Results from the randomised, placebo-controlled, Phase 3 CADENZA study. Eur J Haematol. 2023 Mar; 110(3):280-288.
Röth A, Broome CM, Barcellini W, Jilma B, Hill QA, Cella D, Tvedt THA, Yamaguchi M, Lee M, Shafer F, Wardecki M, Jiang X, Patel P, Joly F, Weitz IC. PMID: 36403132.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Pegcetacoplan versus eculizumab in patients with paroxysmal nocturnal haemoglobinuria (PEGASUS): 48-week follow-up of a randomised, open-label, phase 3, active-comparator, controlled trial. Lancet Haematol. 2022 Sep; 9(9):e648-e659.
de Latour RP, Szer J, Weitz IC, Röth A, Höchsmann B, Panse J, Usuki K, Griffin M, Kiladjian JJ, de Castro CM, Nishimori H, Ajayi T, Al-Adhami M, Deschatelets P, Francois C, Grossi F, Risitano AM, Hillmen P. PMID: 36055332.
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PubMed Mentions:
20 Fields:
Translation:
HumansCTClinical Trials
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Sutimlimab in patients with cold agglutinin disease: results of the randomized placebo-controlled phase 3 CADENZA trial. Blood. 2022 09 01; 140(9):980-991.
Röth A, Berentsen S, Barcellini W, D'Sa S, Jilma B, Michel M, Weitz IC, Yamaguchi M, Nishimura JI, Vos JMI, Storek M, Wong N, Patel P, Jiang X, Vagge DS, Wardecki M, Shafer F, Lee M, Broome CM. PMID: 35687757; PMCID: PMC9437710.
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PubMed Mentions:
27 Fields:
Translation:
HumansCTClinical Trials
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Sutimlimab improves quality of life in patients with cold agglutinin disease: results of patient-reported outcomes from the CARDINAL study. Ann Hematol. 2022 Oct; 101(10):2169-2177.
Röth A, Barcellini W, Tvedt THA, Miyakawa Y, Kuter DJ, Su J, Jiang X, Hobbs W, Arias JM, Shafer F, Weitz IC. PMID: 35999387; PMCID: PMC9463238.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Complement C1s inhibition with sutimlimab results in durable response in cold agglutinin disease: CARDINAL study 1-year interim follow-up results. Haematologica. 2022 07 01; 107(7):1698-1702.
Roth A, Barcellini W, D'Sa S, Miyakawa Y, Broome CM, Michel M, Kuter DJ, Jilma B, Tvedt THA, Weitz IC, Patel P, Jiang X, Reuter C, Su J, Shafer F, Lee M, Berentsen S. PMID: 35172561; PMCID: PMC9244812.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway. Front Immunol. 2021; 12:712572.
Barratt J, Weitz I. PMID: 34566967; PMCID: PMC8458797.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria. N Engl J Med. 2021 03 18; 384(11):1028-1037.
Hillmen P, Szer J, Weitz I, Röth A, Höchsmann B, Panse J, Usuki K, Griffin M, Kiladjian JJ, de Castro C, Nishimori H, Tan L, Hamdani M, Deschatelets P, Francois C, Grossi F, Ajayi T, Risitano A, Peffault de Latour R. PMID: 33730455.
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PubMed Mentions:
122 Fields:
Translation:
HumansCTClinical Trials
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Acute ST-Segment Elevation Myocardial Infarction as Initial Presentation of Atypical Hemolytic-Uremic Syndrome. JACC Case Rep. 2021 Apr; 3(4):561-565.
Chau E, Li S, Xu PZ, Li GX, Ghasem W, Weitz IC, DeClerck BK, DePasquale EC, Yaghmour B. PMID: 34317581; PMCID: PMC8302770.
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PubMed Mentions:
1
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Effectiveness and safety of tacrolimus with or without eltrombopag, as a part of immunosuppressive treatment of aplastic anemia in adults: a retrospective case series. Ann Hematol. 2021 Apr; 100(4):933-939.
Martynova A, Chiu V, Mert M, Hermel D, Weitz IC. PMID: 33420879; PMCID: PMC7960622.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria. Haematologica. 2021 01 01; 106(1):230-237.
Brodsky RA, Peffault de Latour R, Rottinghaus ST, Röth A, Risitano AM, Weitz IC, Hillmen P, Maciejewski JP, Szer J, Lee JW, Kulasekararaj AG, Volles L, Damokosh AI, Ortiz S, Shafner L, Liu P, Hill A, Schrezenmeier H. PMID: 31949012; PMCID: PMC7776354.
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PubMed Mentions:
46 Fields:
Translation:
HumansCTClinical Trials
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Cost burden of breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria receiving ravulizumab versus eculizumab. Hematology. 2020 Dec; 25(1):327-334.
Tomazos I, Sierra JR, Johnston KM, Cheung A, Brodsky RA, Weitz IC. PMID: 32856539.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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C3 inhibition with pegcetacoplan in subjects with paroxysmal nocturnal hemoglobinuria treated with eculizumab. Am J Hematol. 2020 11; 95(11):1334-1343.
de Castro C, Grossi F, Weitz IC, Maciejewski J, Sharma V, Roman E, Brodsky RA, Tan L, Di Casoli C, El Mehdi D, Deschatelets P, Francois C. PMID: 33464651; PMCID: PMC7693064.
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PubMed Mentions:
41 Fields:
Translation:
HumansCTClinical Trials
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Acute dilated cardiomyopathy in the setting of catastrophic antiphospholipid syndrome and thrombotic microangiopathy: A case series and review. EJHaem. 2020 Jul; 1(1):44-50.
Hermel M, Hermel D, Azam S, Shinbane J, Sarcon A, Jones E, Mehta A, Grazette L, Liebman H, Weitz I. PMID: 35847716; PMCID: PMC9175940.
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PubMed Mentions:
1
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Response to: Eculizumab package insert recommendations for meningococcal vaccinations: call for clarity and a targeted approach for use of the drug in neuromyelitis optica spectrum disorder. CNS Spectr. 2021 06; 26(3):195-196.
Pittock SJ, Weitz I, Howard JF, Sabatella G, Mehta S, Franklin J. PMID: 32641193.
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PubMed Mentions:
2 Fields:
Translation:
HumansPHPublic Health
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Multidrug Therapy for Refractory Immune Thrombocytopenia in Pregnancy. Obstet Gynecol. 2020 03; 135(3):723-727.
Chon AH, Chan R, Lee RH, Kwong K, Wertheimer FB, Weitz IC. PMID: 32028499.
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PubMed Mentions: Fields:
Translation:
Humans
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A Retrospective Study of the Combination of Rituximab, Cyclophosphamide and Dexamethasone for the Treatment of Relapsed/Refractory Warm Antibody Autoimmune Hemolytic Anemia. Acta Haematol. 2020; 143(3):244-249.
Piatek CI, Bocian H, Algaze S, Weitz IC, O'Connell C, Liebman HA. PMID: 31665725.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Thrombotic Microangiopathy in Cancer. Semin Thromb Hemost. 2019 Jun; 45(4):348-353.
Weitz IC. PMID: 31041804.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Complement-mediated thrombotic microangiopathy associated with lupus nephritis. Blood Adv. 2018 08 28; 2(16):2090-2094.
Park MH, Caselman N, Ulmer S, Weitz IC. PMID: 30131343; PMCID: PMC6113612.
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PubMed Mentions:
36 Fields:
Translation:
HumansCTClinical Trials
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Ethnic and racial difference in Helicobacter pylori infection in patients with immune thrombocytopenia treated at a major urban medical center. Platelets. 2019; 30(3):413-417.
O'Neill CM, Weitz IC, O'Connell C, Liebman HA. PMID: 29580123.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Thrombotic microangiopathy in cancer. Thromb Res. 2018 04; 164 Suppl 1:S103-S105.
Weitz IC. PMID: 29703465.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Effective treatment of chemotherapy induced atypical Haemolytic Uraemic Syndrome: a case series of 7 treated patients. Br J Haematol. 2018 10; 183(1):136-139.
Weitz IC, Deloughery T. PMID: 28857126.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Autoimmune Hemolytic Anemia. Med Clin North Am. 2017 Mar; 101(2):351-359.
Liebman HA, Weitz IC. PMID: 28189175.
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PubMed Mentions:
27 Fields:
Translation:
Humans
-
OC-14 - Baseline D-dimer levels are predictive of recurrent venous thromboembolism (VTE) at 6 months in cancer patients with VTE treated with tinzaparin. Thromb Res. 2016 Apr; 140 Suppl 1:S174.
Piatek CI, Tagawa ST, Wei-Tsai D, Hanna D, Weitz IC, O'Connell C, Rochanda L, Groshen S, Liebman HA. PMID: 27161687.
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PubMed Mentions:
1 Fields:
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Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria. N Engl J Med. 2015 Sep 10; 373(11):1032-9.
Kelly RJ, Höchsmann B, Szer J, Kulasekararaj A, de Guibert S, Röth A, Weitz IC, Armstrong E, Risitano AM, Patriquin CJ, Terriou L, Muus P, Hill A, Turner MP, Schrezenmeier H, Peffault de Latour R. PMID: 26352814.
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PubMed Mentions:
103 Fields:
Translation:
HumansCTClinical Trials
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Life-threatening delayed hyperhemolytic transfusion reaction in a patient with sickle cell disease: effective treatment with eculizumab followed by rituximab. Transfusion. 2015 Oct; 55(10):2398-403.
Boonyasampant M, Weitz IC, Kay B, Boonchalermvichian C, Liebman HA, Shulman IA. PMID: 25989361.
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PubMed Mentions:
12 Fields:
Translation:
Humans
-
Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia. Ann Hematol. 2014 Nov; 93(11):1839-43.
Aldoss I, Mark L, Vrona J, Ramezani L, Weitz I, Mohrbacher AM, Douer D. PMID: 24906216.
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PubMed Mentions:
16 Fields:
Translation:
HumansCTClinical Trials
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Complement the hemostatic system: an intimate relationship. Thromb Res. 2014 May; 133 Suppl 2:S117-21.
Weitz IC. PMID: 24862131.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Atypical hemolytic uremic syndrome: the role of complement pathway gene mutation analysis. Clin Adv Hematol Oncol. 2014 Apr; 12(4):266-8.
Weitz IC. PMID: 25003358.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479. Blood Transfus. 2014 Jan; 12(1):111-3.
Chaudhary P, Hepgur M, Sarkissian S, Smith RJ, Weitz IC. PMID: 24333077; PMCID: PMC3926711.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure. Cytometry B Clin Cytom. 2014 May; 86(3):175-82.
Raza A, Ravandi F, Rastogi A, Bubis J, Lim SH, Weitz I, Castro-Malaspina H, Galili N, Jawde RA, Illingworth A. PMID: 24227693; PMCID: PMC5594745.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure. Cytometry B Clin Cytom. 2013 Oct 11.
Raza A, Ravandi F, Rastogi A, Bubis J, Lim SH, Weitz I, Castro-Malaspina H, Galili N, Jawde RA, Illingworth A. PMID: 24127323.
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PubMed Mentions:
1 Fields:
-
Cross-sectional validation study of patient-reported outcomes in patients with paroxysmal nocturnal haemoglobinuria. Intern Med J. 2013 Mar; 43(3):298-307.
Weitz I, Meyers G, Lamy T, Cahn JY, Uranga MT, García Vela JA, Sanz MA, Severino B, Kelly RJ, Hillmen P, Hill A. PMID: 22909078.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion. Clin Adv Hematol Oncol. 2012 Nov; 10(11 Suppl 21):1-16.
Szer J, Hill A, Weitz IC. PMID: 23271156.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation. Thromb Res. 2012 Sep; 130(3):361-8.
Weitz IC, Razavi P, Rochanda L, Zwicker J, Furie B, Manly D, Mackman N, Green R, Liebman HA. PMID: 22542362.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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A novel approach to the evaluation of bleeding-related episodes in patients with chronic immune thrombocytopenia. Curr Med Res Opin. 2012 May; 28(5):789-96.
Weitz I, Sanz MA, Henry D, Schipperus M, Godeau B, Northridge K, Gleeson M, Danese M, Deuson R. PMID: 22494019.
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PubMed Mentions:
2 Fields:
Translation:
HumansCTClinical Trials
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Thrombosis in patients with paroxysmal nocturnal hemoglobinuria. Semin Thromb Hemost. 2011 Apr; 37(3):315-21.
Weitz IC. PMID: 21455865.
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PubMed Mentions:
7 Fields:
Translation:
Humans
-
Thrombosis in Paroxysmal Nocturnal Hemoglobinuria - insights into the role of complement in thrombosis. Thromb Res. 2010 Apr; 125 Suppl 2:S106-7.
Weitz IC. PMID: 20433987.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Immune thrombocytopenia in patients with connective tissue disorders and the antiphospholipid antibody syndrome. Hematol Oncol Clin North Am. 2009 Dec; 23(6):1239-49.
Arkfeld DG, Weitz IC. PMID: 19932431.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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The role of oral anticoagulants in tumor biology. Semin Thromb Hemost. 2007 Oct; 33(7):695-8.
Weitz IC, Liebman HA. PMID: 18000797.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Successful rituximab therapy of acquired factor VIII inhibitor in a patient with rheumatoid arthritis. J Clin Rheumatol. 2007 Apr; 13(2):89-91.
Oliveira B, Arkfeld DG, Weitz IC, Shinada S, Ehresmann G. PMID: 17414538.
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PubMed Mentions:
7 Fields:
Translation:
Humans
-
Treatment of immune thrombocytopenia associated with interferon therapy of hepatitis C with the anti-CD20 monoclonal antibody, rituximab. Am J Hematol. 2005 Feb; 78(2):138-41.
Weitz IC. PMID: 15682410.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Thromboembolic complications of cancer: epidemiology, pathogenesis, diagnosis, and treatment. Am J Hematol. 2003 Jan; 72(1):43-52.
Sutherland DE, Weitz IC, Liebman HA. PMID: 12508268.
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PubMed Mentions:
50 Fields:
Translation:
Humans
-
Does leucovorin alter the intratumoral pharmacokinetics of 5-fluorouracil (5-FU)? A Southwest Oncology Group study. Invest New Drugs. 2002 Nov; 20(4):369-76.
Presant CA, Jacobson J, Wolf W, Waluch V, Weitz IC, Macdonald JS, Southwest Oncology Group. PMID: 12448653.
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PubMed Mentions:
3 Fields:
Translation:
HumansCTClinical Trials
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Chemotherapy-induced activation of hemostasis: effect of a low molecular weight heparin (dalteparin sodium) on plasma markers of hemostatic activation. Thromb Haemost. 2002 Aug; 88(2):213-20.
Weitz IC, Israel VK, Waisman JR, Presant CA, Rochanda L, Liebman HA. PMID: 12195692.
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PubMed Mentions:
6 Fields:
Translation:
HumansCTClinical Trials
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Enhancement of fluorouracil uptake in human colorectal and gastric cancers by interferon or by high-dose methotrexate: An in vivo human study using noninvasive (19)F-magnetic resonance spectroscopy. J Clin Oncol. 2000 Jan; 18(2):255-61.
Presant CA, Wolf W, Waluch V, Wiseman CL, Weitz I, Shani J. PMID: 10637237.
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PubMed Mentions:
4 Fields:
Translation:
HumansCTClinical Trials
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Tamoxifen-associated venous thrombosis and activated protein C resistance due to factor V Leiden. Cancer. 1997 May 15; 79(10):2024-7.
Weitz IC, Israel VK, Liebman HA. PMID: 9149031.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Des-gamma-carboxy (abnormal) prothrombin and hepatocellular carcinoma: a critical review. Hepatology. 1993 Oct; 18(4):990-7.
Weitz IC, Liebman HA. PMID: 8406374.
View in:
PubMed Mentions:
40 Fields:
Translation:
Humans
-
Excessive fibrinolysis in amyloidosis associated with elevated plasma single-chain urokinase. Am J Clin Pathol. 1992 Nov; 98(5):534-41.
Liebman HA, Carfagno MK, Weitz IC, Berard P, Diiorio JM, Vosburgh E, Simms RW. PMID: 1485607.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans