Michael R. Lieber, MD, PhD

Title(s)Professor of Pathology
AddressNTT 1441 Eastlake Ave
Health Sciences Campus
Los Angeles CA 90089-9176
Phone+1 323 865 0568
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    Other Positions
    Title(s)Rita and Edward Polusky Chair in Basic Cancer Research

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    The web page for the Lieber lab is: lieber.usc.edu

    The following overview of research at the Lieber lab is taken from lieber.usc.edu.

    DNA double-strand breaks occur as part of the physiologic development of the immune repertoire in B and T lymphocytes. We study the manner in which these breaks are generated in a process called V(D)J recombination. Defects in the normal enzymes that generate these breaks can result in inherited forms of human severe combined immune deficiency (SCID). We study the biochemistry of how these proteins function, and we study how mutations in them result in SCID. Once DNA breaks are generated, they must be repaired. All cells of the body possess the ability to repair double-strand DNA breaks because all cells must deal with pathologic breaks in DNA that arise due to external radiation or due to free radicals of oxidative metabolism. The major pathway for repairing double-strand breaks in mammalian cells is called nonhomologous DNA end joining (NHEJ). If this pathway is defective in lymphocytes, then the breaks generated can not be repaired. Such defects also result in SCID. If the NHEJ pathway is defectve in all cells of the body, not only is the immune system affected, but the entire body is extremely vulnerable to ionizing radiation. Our laboratory has made substantial progress in defining proteins important in the NHEJ pathway. The first protein in the NHEJ pathway, Ku, binds at the broken DNA ends. The Artemis:DNA-PKcs complex is recruited to the DNA end by Ku. This binding activates the protein kinase activity of DNA-PKcs, which then phosphorylates Artemis and makes the Artemis:DNA-PKcs complex a potent nuclease for trimming DNA ends. Polymerase mu and lambda fill-in gaps, and polymerase mu can add nucleotides template-indepenently, like TdT. Finally, DNA ligase IV, XRCC4, and XLF form the ligation complex which ligates the double-strand break. We are interested in how all of these proteins carry out their functions and how their structure is important for this, and we are interested in identifying any other proteins that might be in th is pathway. We are also interested in how chromatin structure affects these proteins as they repair DNA breaks. The process of NHEJ is intrinsically imprecise. We suspect that this imprecision may contribute to the aging of somatic cells over time as well as to cancer. We are currently investigating this possibility using cell culture models, animal models, and analysis of human cells. Identification of inhibitors of NHEJ would be useful in cancer therapy and in improving gene targeting in human stem cells, and hence, we are trying to identify inhibitors of the pathway and individual components.

    Mistakes of V(D)J recombination account for about 40% of nonHodgkin's lymphoma. We study how the normal V(D)J recombination process goes awry. Specifically, why do some ends fail to join properly, and why do some sites adjacent to oncogenes get cleaved inadvertently. The inadvertent cleavage of some sites may be due to an altered DNA structure at those sites. We are trying to understand the extent to which such DNA structural deviations contribute to the fragility of such common chromosomal translocation hotspots.

    Class switch recombination is a second developmentally programmed gene rearrangement process in the vertebrate immune system, and it occurs in B cells at the Ig heavy chain locus. Class switching is the process that results in IgM being converted to IgG, IgA, or IgE. Humans borne with defects in class switching die early in life because they can not make IgA for protection of their lungs. The enzyme that initiates the class switch gene rearrangement process is a cytidine deaminase, called AID, that only functions on single-stranded DNA. We have focused on how the class switch recombination regions become single-stranded. Upon transcription, the RNA remains associated with the template DNA strand, resulting in an R-loop structure. The R-loop structure provides a substantial amount of single-stranded DNA at which the AID enzyme can act. We are interested in determining the factors that favor R-loop formation. In some lymphomas, the class switch recombination process goes awry, just as in V(D)J recombination. We are also studying these events.

    In summary, the Lieber lab focuses on how physiologic and pathologic gene rearrangements function in the immune system and in cancer and aging.

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    Collapse Research Activities and Funding
    Mechanisms of Human Lymphoid Chromosomal Translocation
    NIH R01CA196671Sep 1, 2016 - Aug 31, 2022
    Role: Principal Investigator
    Site-Specific Recombination in Human Health & Disease
    NIH R35GM118009Jun 1, 2016 - May 31, 2026
    Role: Principal Investigator
    Selective Inhibitors of the Artemis Endonuclease
    NIH R03MH095489Feb 6, 2012 - Dec 31, 2014
    Role: Principal Investigator
    Mechanism and Regulation of Human Nonhomologous DNA End Joining
    NIH R01CA100504Aug 1, 2003 - Jul 31, 2022
    Role: Principal Investigator
    Mechanism of R-loop Formation in CSR and SHM
    NIH R01GM056984Sep 1, 1998 - Aug 31, 2017
    Role: Principal Investigator
    Normal and Mutant Lymphoid V(D)J Recombinase
    NIH R01GM043236Jun 1, 1990 - Aug 31, 2017
    Role: Principal Investigator
    NIH R37CA051105Jan 1, 1990 - Aug 31, 2015
    Role: Principal Investigator
    NIH R01CA051105Jan 1, 1990 - Aug 31, 2005
    Role: Principal Investigator
    NIH T32CA009569Sep 1, 1987 - Jul 31, 2003
    Role: Principal Investigator
    Postdoctoral Training in Tumor Biology
    NIH T32CA009151Jul 1, 1975 - Apr 30, 2016
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Nonhomologous DNA end joining of nucleosomal substrates in a purified system. DNA Repair (Amst). 2021 10; 106:103193. Gerodimos CA, Watanabe G, Lieber MR. PMID: 34339948.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies. Cell Rep. 2021 Jul 13; 36(2):109387. Liu D, Loh YE, Hsieh CL, Lieber MR. PMID: 34260910.
      View in: PubMed   Mentions:    Fields:    
    3. NAD+ is not utilized as a co-factor for DNA ligation by human DNA ligase IV. Nucleic Acids Res. 2020 12 16; 48(22):12746-12750. Zhao B, Naila T, Lieber MR, Tomkinson AE. PMID: 33264406.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Temporally uncoupled signal and coding joint formation in human V(D)J recombination. Mol Immunol. 2020 12; 128:227-234. Hsieh CL, Okitsu CY, Lieber MR. PMID: 33157352.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. The molecular basis and disease relevance of non-homologous DNA end joining. Nat Rev Mol Cell Biol. 2020 12; 21(12):765-781. Zhao B, Rothenberg E, Ramsden DA, Lieber MR. PMID: 33077885.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    6. Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features. J Biol Chem. 2020 08 28; 295(35):12368-12377. Karim MF, Liu S, Laciak AR, Volk L, Koszelak-Rosenblum M, Lieber MR, Wu M, Curtis R, Huang NN, Carr G, Zhu G. PMID: 32576658.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system. Nucleic Acids Res. 2020 04 17; 48(7):3605-3618. Zhao B, Watanabe G, Lieber MR. PMID: 32052035.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    8. DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination. Mol Immunol. 2020 04; 120:93-100. Anne Esguerra Z, Watanabe G, Okitsu CY, Hsieh CL, Lieber MR. PMID: 32113132.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Current insights into the mechanism of mammalian immunoglobulin class switch recombination. Crit Rev Biochem Mol Biol. 2019 08; 54(4):333-351. Yu K, Lieber MR. PMID: 31509023.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    10. The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis. Nat Commun. 2019 08 09; 10(1):3588. Zhao B, Watanabe G, Morten MJ, Reid DA, Rothenberg E, Lieber MR. PMID: 31399561.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    11. Constitutively active Artemis nuclease recognizes structures containing single-stranded DNA configurations. DNA Repair (Amst). 2019 11; 83:102676. Pannunzio NR, Lieber MR. PMID: 31377101.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Transposons to V(D)J Recombination: Evolution of the RAG Reaction. Trends Immunol. 2019 08; 40(8):668-670. Lieber MR. PMID: 31307890.
      View in: PubMed   Mentions:    Fields:    
    13. Structural evidence for an in trans base selection mechanism involving Loop1 in polymerase μ at an NHEJ double-strand break junction. J Biol Chem. 2019 07 05; 294(27):10579-10595. Loc'h J, Gerodimos CA, Rosario S, Tekpinar M, Lieber MR, Delarue M. PMID: 31138645.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    14. AID and Reactive Oxygen Species Can Induce DNA Breaks within Human Chromosomal Translocation Fragile Zones. Mol Cell. 2019 02 07; 73(3):639. Pannunzio NR, Lieber MR. PMID: 30735656.
      View in: PubMed   Mentions: 1     Fields:    
    15. Reply: Radiation Dose Does Matter: Mechanistic Insights into DNA Damage and Repair Support the Linear No-Threshold Model of Low-Dose Radiation Health Risks. J Nucl Med. 2019 03; 60(3):437-438. Duncan JR, Lieber MR, Adachi N, Wahl RL. PMID: 30630943.
      View in: PubMed   Mentions:    Fields:    
    16. Reply: Radiation Dose Does Matter: Mechanistic Insights into DNA Damage and Repair Support the Linear No-Threshold Model of Low-Dose Radiation Health Risks J Nucl Med. 2018 11; 59(11):1780-1781. Duncan JR, Lieber MR, Adachi N, Wahl RL. PMID: 30262519.
      View in: PubMed   Mentions:    Fields:    
    17. Radiation Dose Does Matter: Mechanistic Insights into DNA Damage and Repair Support the Linear No-Threshold Model of Low-Dose Radiation Health Risks. J Nucl Med. 2018 07; 59(7):1014-1016. Duncan JR, Lieber MR, Adachi N, Wahl RL. PMID: 29853652.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Concept of DNA Lesion Longevity and Chromosomal Translocations. Trends Biochem Sci. 2018 07; 43(7):490-498. Pannunzio NR, Lieber MR. PMID: 29735400.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    19. Nonhomologous DNA end-joining for repair of DNA double-strand breaks. J Biol Chem. 2018 07 06; 293(27):10512-10523. Pannunzio NR, Watanabe G, Lieber MR. PMID: 29247009.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    20. AID and Reactive Oxygen Species Can Induce DNA Breaks within Human Chromosomal Translocation Fragile Zones. Mol Cell. 2017 Dec 07; 68(5):901-912.e3. Pannunzio NR, Lieber MR. PMID: 29220655.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. Structural step forward for NHEJ. Cell Res. 2017 11; 27(11):1304-1306. Watanabe G, Lieber MR, Williams D. PMID: 28925388.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining. Cell Rep. 2017 Sep 19; 20(12):2810-2819. Conlin MP, Reid DA, Small GW, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E. PMID: 28930678.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    23. DNA Repair After Exposure to Ionizing Radiation Is Not Error-Free. J Nucl Med. 2018 02; 59(2):348. Duncan JR, Lieber MR, Adachi N, Wahl RL. PMID: 28775198.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity. J Biol Chem. 2017 08 25; 292(34):13914-13924. Gerodimos CA, Chang HHY, Watanabe G, Lieber MR. PMID: 28696258.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    25. Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol. 2017 08; 18(8):495-506. Chang HHY, Pannunzio NR, Adachi N, Lieber MR. PMID: 28512351.
      View in: PubMed   Mentions: 340     Fields:    Translation:HumansAnimalsCells
    26. Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry. Nucleic Acids Res. 2017 02 28; 45(4):1872-1878. Reid DA, Conlin MP, Yin Y, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E. PMID: 27924007.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    27. Real-time analysis of RAG complex activity in V(D)J recombination. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):11853-11858. Zagelbaum J, Shimazaki N, Esguerra ZA, Watanabe G, Lieber MR, Rothenberg E. PMID: 27702897.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    28. Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency. J Biol Chem. 2016 Nov 18; 291(47):24377-24389. Chang HHY, Watanabe G, Gerodimos CA, Ochi T, Blundell TL, Jackson SP, Lieber MR. PMID: 27703001.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    29. A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618. Rand KA, Song C, Dean E, Serie DJ, Curtin K, Sheng X, Hu D, Huff CA, Bernal-Mizrachi L, Tomasson MH, Ailawadhi S, Singhal S, Pawlish K, Peters ES, Bock CH, Stram A, Van Den Berg DJ, Edlund CK, Conti DV, Zimmerman T, Hwang AE, Huntsman S, Graff J, Nooka A, Kong Y, Pregja SL, Berndt SI, Blot WJ, Carpten J, Casey G, Chu L, Diver WR, Stevens VL, Lieber MR, Goodman PJ, Hennis AJ, Hsing AW, Mehta J, Kittles RA, Kolb S, Klein EA, Leske C, Murphy AB, Nemesure B, Neslund-Dudas C, Strom SS, Vij R, Rybicki BA, Stanford JL, Signorello LB, Witte JS, Ambrosone CB, Bhatti P, John EM, Bernstein L, Zheng W, Olshan AF, Hu JJ, Ziegler RG, Nyante SJ, Bandera EV, Birmann BM, Ingles SA, Press MF, Atanackovic D, Glenn MJ, Cannon-Albright LA, Jones B, Tricot G, Martin TG, Kumar SK, Wolf JL, Deming Halverson SL, Rothman N, Brooks-Wilson AR, Rajkumar SV, Kolonel LN, Chanock SJ, Slager SL, Severson RK, Janakiraman N, Terebelo HR, Brown EE, De Roos AJ, Mohrbacher AF, Colditz GA, Giles GG, Spinelli JJ, Chiu BC, Munshi NC, Anderson KC, Levy J, Zonder JA, Orlowski RZ, Lonial S, Camp NJ, Vachon CM, Ziv E, Stram DO, Hazelett DJ, Haiman CA, Cozen W. PMID: 27587788.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Mechanisms of human lymphoid chromosomal translocations. Nat Rev Cancer. 2016 05 25; 16(6):387-98. Lieber MR. PMID: 27220482.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    31. Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex. Nucleic Acids Res. 2016 06 20; 44(11):4991-7. Chang HH, Lieber MR. PMID: 27198222.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    32. SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV. DNA Repair (Amst). 2016 07; 43:18-23. Greco GE, Matsumoto Y, Brooks RC, Lu Z, Lieber MR, Tomkinson AE. PMID: 27235626.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    33. RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure. Mol Cell. 2016 05 05; 62(3):327-334. Pannunzio NR, Lieber MR. PMID: 27153532.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    34. Dissecting the Roles of Divergent and Convergent Transcription in Chromosome Instability. Cell Rep. 2016 Feb 09; 14(5):1025-1031. Pannunzio NR, Lieber MR. PMID: 26804908.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. Unifying the DNA end-processing roles of the artemis nuclease: Ku-dependent artemis resection at blunt DNA ends. J Biol Chem. 2015 Oct 02; 290(40):24036-50. Chang HH, Watanabe G, Lieber MR. PMID: 26276388.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    36. Convergent BCL6 and lncRNA promoters demarcate the major breakpoint region for BCL6 translocations. Blood. 2015 Oct 01; 126(14):1730-1. Lu Z, Pannunzio NR, Greisman HA, Casero D, Parekh C, Lieber MR. PMID: 26276666.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    37. The repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombination. Mol Immunol. 2015 Oct; 67(2 Pt B):524-31. Zhang ZZ, Pannunzio NR, Lu Z, Hsu E, Yu K, Lieber MR. PMID: 26277278.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015 Jul; 16(7):766-774. Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M. PMID: 25985233.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    39. Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2575-84. Reid DA, Keegan S, Leo-Macias A, Watanabe G, Strande NT, Chang HH, Oksuz BA, Fenyo D, Lieber MR, Ramsden DA, Rothenberg E. PMID: 25941401.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    40. Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination. Mol Immunol. 2015 Aug; 66(2):284-9. Zhang ZZ, Hsieh CL, Okitsu CY, Han L, Yu K, Lieber MR. PMID: 25899867.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    41. Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids. BMC Res Notes. 2015 Apr 08; 8:127. Zhang ZZ, Pannunzio NR, Hsieh CL, Yu K, Lieber MR. PMID: 25890199.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    42. Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin. Mol Cell Biol. 2015 Apr; 35(7):1209-22. Lu Z, Lieber MR, Tsai AG, Pardo CE, Müschen M, Kladde MP, Hsieh CL. PMID: 25624348.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    43. The role of G-density in switch region repeats for immunoglobulin class switch recombination. Nucleic Acids Res. 2014 Dec 01; 42(21):13186-93. Zhang ZZ, Pannunzio NR, Hsieh CL, Yu K, Lieber MR. PMID: 25378327.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    44. Histone methylation and V(D)J recombination. Int J Hematol. 2014 Sep; 100(3):230-7. Shimazaki N, Lieber MR. PMID: 25060705.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    45. The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites. Cell Rep. 2014 Jul 24; 8(2):557-69. Zhang ZZ, Pannunzio NR, Han L, Hsieh CL, Yu K, Lieber MR. PMID: 25017067.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    46. Modeling of the RAG reaction mechanism. Cell Rep. 2014 Apr 24; 7(2):307-315. Askary A, Shimazaki N, Bayat N, Lieber MR. PMID: 24703851.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    47. Non-homologous end joining often uses microhomology: implications for alternative end joining. DNA Repair (Amst). 2014 May; 17:74-80. Pannunzio NR, Li S, Watanabe G, Lieber MR. PMID: 24613510.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    48. Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity. J Biol Chem. 2014 Mar 14; 289(11):7825-34. Li S, Chang HH, Niewolik D, Hedrick MP, Pinkerton AB, Hassig CA, Schwarz K, Lieber MR. PMID: 24500713.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    49. Reproducibility and reliability of SNP analysis using human cellular DNA at or near nanogram levels. BMC Res Notes. 2013 Dec 06; 6:515. Okitsu CY, Van Den Berg DJ, Lieber MR, Hsieh CL. PMID: 24314330.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts. Aging Cell. 2013 Apr; 12(2):269-79. Hsieh JC, Van Den Berg D, Kang H, Hsieh CL, Lieber MR. PMID: 23425690.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    51. BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements. Blood. 2013 May 30; 121(22):4551-4. Lu Z, Tsai AG, Akasaka T, Ohno H, Jiang Y, Melnick AM, Greisman HA, Lieber MR. PMID: 23476051.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    52. A noncatalytic function of the ligation complex during nonhomologous end joining. J Cell Biol. 2013 Jan 21; 200(2):173-86. Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, Jeggo PA, Lieber MR, Modesti M, Calsou P. PMID: 23337116.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    53. Detection and characterization of R-loops at the murine immunoglobulin Sα region. Mol Immunol. 2013 Jun; 54(2):208-16. Kao YP, Hsieh WC, Hung ST, Huang CW, Lieber MR, Huang FT. PMID: 23287599.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    54. Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation. Mol Cell Biol. 2013 Mar; 33(5):947-57. Cui X, Lu Z, Kurosawa A, Klemm L, Bagshaw AT, Tsai AG, Gemmell N, Müschen M, Adachi N, Hsieh CL, Lieber MR. PMID: 23263985.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas. Blood. 2012 Oct 04; 120(14):2864-7. Greisman HA, Lu Z, Tsai AG, Greiner TC, Yi HS, Lieber MR. PMID: 22915650.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    56. Mechanistic basis for RAG discrimination between recombination sites and the off-target sites of human lymphomas. Mol Cell Biol. 2012 Jan; 32(2):365-75. Shimazaki N, Askary A, Swanson PC, Lieber MR. PMID: 22064481.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    57. Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system. J Biol Chem. 2011 Oct 21; 286(42):36368-77. Li S, Kanno S, Watanabe R, Ogiwara H, Kohno T, Watanabe G, Yasui A, Lieber MR. PMID: 21885877.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    58. Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma. Nucleic Acids Res. 2011 Feb; 39(3):936-48. Nambiar M, Goldsmith G, Moorthy BT, Lieber MR, Joshi MV, Choudhary B, Hosur RV, Raghavan SC. PMID: 20880994.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    59. t(X;14)(p22;q32)/t(Y;14)(p11;q32) CRLF2-IGH translocations from human B-lineage ALLs involve CpG-type breaks at CRLF2, but CRLF2/P2RY8 intrachromosomal deletions do not. Blood. 2010 Sep 16; 116(11):1993-4. Tsai AG, Yoda A, Weinstock DM, Lieber MR. PMID: 20847213.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    60. SnapShot: Nonhomologous DNA end joining (NHEJ). Cell. 2010 Aug 06; 142(3):496-496.e1. Lieber MR, Wilson TE. PMID: 20691907.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    61. Is there any genetic instability in human cancer? DNA Repair (Amst). 2010 Aug 05; 9(8):858; discussion 859-60. Shibata D, Lieber MR. PMID: 20605538.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    62. The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not. Blood. 2010 Apr 29; 115(17):3640-1; author reply 3641-2. Tsai AG, Lu Z, Lieber MR. PMID: 20430965.
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    63. NHEJ and its backup pathways in chromosomal translocations. Nat Struct Mol Biol. 2010 Apr; 17(4):393-5. Lieber MR. PMID: 20368722.
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    64. Mechanisms of chromosomal rearrangement in the human genome. BMC Genomics. 2010 Feb 10; 11 Suppl 1:S1. Tsai AG, Lieber MR. PMID: 20158866.
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    65. DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst). 2010 Apr 04; 9(4):429-37. Gu J, Li S, Zhang X, Wang LC, Niewolik D, Schwarz K, Legerski RJ, Zandi E, Lieber MR. PMID: 20117966.
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    66. Cytosines, but not purines, determine recombination activating gene (RAG)-induced breaks on heteroduplex DNA structures: implications for genomic instability. J Biol Chem. 2010 Mar 05; 285(10):7587-97. Naik AK, Lieber MR, Raghavan SC. PMID: 20051517.
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    67. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem. 2010; 79:181-211. Lieber MR. PMID: 20192759.
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    68. Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans. Subcell Biochem. 2010; 50:279-96. Lieber MR, Gu J, Lu H, Shimazaki N, Tsai AG. PMID: 20012587.
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    69. Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site. Mol Cell Biol. 2010 Jan; 30(1):146-59. Roy D, Zhang Z, Lu Z, Hsieh CL, Lieber MR. PMID: 19841062.
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    70. Successful treatment of calcific uremic arteriolopathy in a pediatric dialysis patient. Pediatr Nephrol. 2010 Feb; 25(2):357-62. Amin N, Gonzalez E, Lieber M, Salusky IB, Zaritsky JJ. PMID: 19885686.
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    71. The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell. 2009 Sep 08; 16(3):232-45. Klemm L, Duy C, Iacobucci I, Kuchen S, von Levetzow G, Feldhahn N, Henke N, Li Z, Hoffmann TK, Kim YM, Hofmann WK, Jumaa H, Groffen J, Heisterkamp N, Martinelli G, Lieber MR, Casellas R, Müschen M. PMID: 19732723.
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    72. H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations. Mol Cell. 2009 Jun 12; 34(5):535-44. Shimazaki N, Tsai AG, Lieber MR. PMID: 19524534.
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    73. G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter. Mol Cell Biol. 2009 Jun; 29(11):3124-33. Roy D, Lieber MR. PMID: 19307304.
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    74. Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. J Biol Chem. 2009 Mar 13; 284(11):7157-64. Tsai AG, Engelhart AE, Hatmal MM, Houston SI, Hud NV, Haworth IS, Lieber MR. PMID: 19106104.
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    75. Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell. 2008 Dec 12; 135(6):1130-42. Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh CL, Lieber MR. PMID: 19070581.
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    76. A histidine in the beta-CASP domain of Artemis is critical for its full in vitro and in vivo functions. DNA Repair (Amst). 2009 Feb 01; 8(2):202-8. de Villartay JP, Shimazaki N, Charbonnier JB, Fischer A, Mornon JP, Lieber MR, Callebaut I. PMID: 19022407.
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    77. Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol. 2008 11; 9(11):903-10. Longo VD, Lieber MR, Vijg J. PMID: 18946478.
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    78. Unexpected complexity at breakpoint junctions in phenotypically normal individuals and mechanisms involved in generating balanced translocations t(1;22)(p36;q13). Genome Res. 2008 Nov; 18(11):1733-42. Gajecka M, Gentles AJ, Tsai A, Chitayat D, Mackay KL, Glotzbach CD, Lieber MR, Shaffer LG. PMID: 18765821.
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    79. A biochemically defined system for coding joint formation in V(D)J recombination. Mol Cell. 2008 Aug 22; 31(4):485-497. Lu H, Shimazaki N, Raval P, Gu J, Watanabe G, Schwarz K, Swanson PC, Lieber MR. PMID: 18722175.
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    80. FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell. 2008 Apr 11; 30(1):86-97. Heo K, Kim H, Choi SH, Choi J, Kim K, Gu J, Lieber MR, Yang AS, An W. PMID: 18406329.
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    81. DNA-PKcs at 7 angstrom: insights for DNA repair. Structure. 2008 Mar; 16(3):334-6. Shimazaki N, Lieber MR. PMID: 18334206.
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    82. Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining. Genes Dev. 2008 Feb 15; 22(4):411-5. Gu J, Lieber MR. PMID: 18281457.
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    83. RAGs found "not guilty": cleared by DNA evidence. Blood. 2008 Feb 15; 111(4):1750. Tsai AG, Lieber MR. PMID: 19048671.
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    84. Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system. Cell Res. 2008 Jan; 18(1):125-33. Lieber MR, Lu H, Gu J, Schwarz K. PMID: 18087292.
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    85. Mechanistic aspects of lymphoid chromosomal translocations. J Natl Cancer Inst Monogr. 2008; (39):8-11. Lieber MR, Raghavan SC, Yu K. PMID: 18647994.
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    86. The mechanism of human nonhomologous DNA end joining. J Biol Chem. 2008 Jan 04; 283(1):1-5. Lieber MR. PMID: 17999957.
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    87. Mechanism of R-loop formation at immunoglobulin class switch sequences. Mol Cell Biol. 2008 Jan; 28(1):50-60. Roy D, Yu K, Lieber MR. PMID: 17954560.
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    88. Extent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombination. Nucleic Acids Res. 2007; 35(20):6917-23. Lu H, Schwarz K, Lieber MR. PMID: 17932067.
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    89. Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence. Nucleic Acids Res. 2007; 35(17):5755-62. Gu J, Lu H, Tsai AG, Schwarz K, Lieber MR. PMID: 17717001.
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    90. Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region. Mol Cell Biol. 2007 Aug; 27(16):5921-32. Huang FT, Yu K, Balter BB, Selsing E, Oruc Z, Khamlichi AA, Hsieh CL, Lieber MR. PMID: 17562862.
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    91. DNA structure and human diseases. Front Biosci. 2007 May 01; 12:4402-8. Raghavan SC, Lieber MR. PMID: 17485384.
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    92. Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity. J Biol Chem. 2007 Apr 13; 282(15):11155-62. Lu H, Pannicke U, Schwarz K, Lieber MR. PMID: 17317666.
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    93. The structure-specific nicking of small heteroduplexes by the RAG complex: implications for lymphoid chromosomal translocations. DNA Repair (Amst). 2007 Jun 01; 6(6):751-9. Raghavan SC, Gu J, Swanson PC, Lieber MR. PMID: 17307402.
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    94. XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J. 2007 Feb 21; 26(4):1010-23. Gu J, Lu H, Tippin B, Shimazaki N, Goodman MF, Lieber MR. PMID: 17290226.
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    95. Hyperbaric oxygen in treatment of neonatal arterial thromboembolism of lower extremities. J Perinatol. 2006 Dec; 26(12):777-9. Wiebers J, Purdy I, Lieber M, Milisavljevic V. PMID: 17122788.
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    96. DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs. J Biol Chem. 2006 Nov 10; 281(45):33900-9. Niewolik D, Pannicke U, Lu H, Ma Y, Wang LC, Kulesza P, Zandi E, Lieber MR, Schwarz K. PMID: 16914548.
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    97. The polymerases for V(D)J recombination. Immunity. 2006 Jul; 25(1):7-9. Lieber MR. PMID: 16860749.
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    98. Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. DNA Repair (Amst). 2006 Sep 08; 5(9-10):1234-45. Lieber MR, Yu K, Raghavan SC. PMID: 16793349.
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    99. DNA structures at chromosomal translocation sites. Bioessays. 2006 May; 28(5):480-94. Raghavan SC, Lieber MR. PMID: 16615081.
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    100. Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5030-5. Huang FT, Yu K, Hsieh CL, Lieber MR. PMID: 16547142.
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    101. Analysis of non-B DNA structure at chromosomal sites in the mammalian genome. Methods Enzymol. 2006; 409:301-16. Raghavan SC, Tsai A, Hsieh CL, Lieber MR. PMID: 16793408.
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    102. Detection and structural analysis of R-loops. Methods Enzymol. 2006; 409:316-29. Yu K, Roy D, Huang FT, Lieber MR. PMID: 16793409.
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    103. In vitro nonhomologous DNA end joining system. Methods Enzymol. 2006; 408:502-10. Ma Y, Lieber MR. PMID: 16793389.
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    104. Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol. 2006 Jan; 36(1):224-35. Buck D, Moshous D, de Chasseval R, Ma Y, le Deist F, Cavazzana-Calvo M, Fischer A, Casanova JL, Lieber MR, de Villartay JP. PMID: 16358361.
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    105. Hybrid joint formation in human V(D)J recombination requires nonhomologous DNA end joining. DNA Repair (Amst). 2006 Feb 03; 5(2):278-85. Raghavan SC, Tong J, Lieber MR. PMID: 16275127.
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    106. Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model. . 2005 Sep; 4(9):1193-200. Ma Y, Lu H, Schwarz K, Lieber MR. PMID: 16082219.
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    107. The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis. J Biol Chem. 2005 Oct 07; 280(40):33839-46. Ma Y, Pannicke U, Lu H, Niewolik D, Schwarz K, Lieber MR. PMID: 16093244.
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    108. Both V(D)J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent. Mol Cell Biol. 2005 Aug; 25(15):6475-84. Raghavan SC, Hsieh CL, Lieber MR. PMID: 16024785.
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    109. The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst). 2005 Jul 12; 4(7):845-51. Ma Y, Schwarz K, Lieber MR. PMID: 15936993.
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    110. Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro. Mol Cell Biol. 2005 Jul; 25(14):5904-19. Raghavan SC, Swanson PC, Ma Y, Lieber MR. PMID: 15988007.
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    111. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J Biol Chem. 2005 Jun 17; 280(24):22749-60. Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh CL, Haworth IS, Lieber MR. PMID: 15840562.
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    112. Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops. Mol Cell Biol. 2005 Mar; 25(5):1730-6. Yu K, Roy D, Bayramyan M, Haworth IS, Lieber MR. PMID: 15713630.
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    113. Omenn syndrome due to ARTEMIS mutations. Blood. 2005 Jun 01; 105(11):4179-86. Ege M, Ma Y, Manfras B, Kalwak K, Lu H, Lieber MR, Schwarz K, Pannicke U. PMID: 15731174.
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    114. Generation and characterization of endonuclease G null mice. Mol Cell Biol. 2005 Jan; 25(1):294-302. Irvine RA, Adachi N, Shibata DK, Cassell GD, Yu K, Karanjawala ZE, Hsieh CL, Lieber MR. PMID: 15601850.
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    115. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell. 2004 Dec 03; 16(5):701-13. Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, Hsieh CL, Schwarz K, Lieber MR. PMID: 15574326.
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    116. The efficacy of hyperbaric oxygen therapy in the treatment of radiation-induced late side effects. Int J Radiat Oncol Biol Phys. 2004 Nov 01; 60(3):871-8. Bui QC, Lieber M, Withers HR, Corson K, van Rijnsoever M, Elsaleh H. PMID: 15465205.
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    117. Genetic interactions between BLM and DNA ligase IV in human cells. J Biol Chem. 2004 Dec 31; 279(53):55433-42. So S, Adachi N, Lieber MR, Koyama H. PMID: 15509577.
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    118. Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region. J Biol Chem. 2004 Oct 29; 279(44):46213-25. Raghavan SC, Houston S, Hegde BG, Langen R, Haworth IS, Lieber MR. PMID: 15328356.
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    119. The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):817-26. Lieber MR, Ma Y, Pannicke U, Schwarz K. PMID: 15279766.
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    120. Chromosomal translocations and non-B DNA structures in the human genome. . 2004 Jun; 3(6):762-8. Raghavan SC, Lieber MR. PMID: 15254430.
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    121. DNA damage and aging. Mech Ageing Dev. 2004 Jun; 125(6):405-16. Karanjawala ZE, Lieber MR. PMID: 15272504.
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    122. Functional and biochemical dissection of the structure-specific nuclease ARTEMIS. EMBO J. 2004 May 05; 23(9):1987-97. Pannicke U, Ma Y, Hopfner KP, Niewolik D, Lieber MR, Schwarz K. PMID: 15071507.
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    123. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature. 2004 Mar 04; 428(6978):88-93. Raghavan SC, Swanson PC, Wu X, Hsieh CL, Lieber MR. PMID: 14999286.
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    124. Kinetic analysis of the nicking and hairpin formation steps in V(D)J recombination. DNA Repair (Amst). 2004 Jan 05; 3(1):67-75. Yu K, Taghva A, Ma Y, Lieber MR. PMID: 14697761.
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    125. Ageing, repetitive genomes and DNA damage. Nat Rev Mol Cell Biol. 2004 Jan; 5(1):69-75. Lieber MR, Karanjawala ZE. PMID: 14708011.
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    126. Developmental retinal apoptosis in Ku86-/- mice. DNA Repair (Amst). 2003 Dec 09; 2(12):1429-34. Karanjawala ZE, Hinton DR, Oh E, Hsieh CL, Lieber MR. PMID: 14642570.
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    127. DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J Biol Chem. 2004 Feb 20; 279(8):6496-500. Yu K, Huang FT, Lieber MR. PMID: 14645244.
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    128. Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism. DNA Repair (Amst). 2003 Nov 21; 2(11):1163-74. Yu K, Lieber MR. PMID: 14599739.
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    129. Human severe combined immune deficiency and DNA repair. Bioessays. 2003 Nov; 25(11):1061-70. Schwarz K, Ma Y, Pannicke U, Lieber MR. PMID: 14579247.
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    130. Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol. 2003 Sep; 4(9):712-20. Lieber MR, Ma Y, Pannicke U, Schwarz K. PMID: 14506474.
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    131. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol. 2003 May; 4(5):442-51. Yu K, Chedin F, Hsieh CL, Wilson TE, Lieber MR. PMID: 12679812.
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    132. Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res. 2003 Apr 15; 31(8):2157-67. Smith J, Riballo E, Kysela B, Baldeyron C, Manolis K, Masson C, Lieber MR, Papadopoulo D, Jeggo P. PMID: 12682366.
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    133. Overexpression of Cu/Zn superoxide dismutase is lethal for mice lacking double-strand break repair. DNA Repair (Amst). 2003 Mar 01; 2(3):285-94. Karanjawala ZE, Hsieh CL, Lieber MR. PMID: 12547391.
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    134. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16916-21. Chedin F, Lieber MR, Hsieh CL. PMID: 12481029.
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    135. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst). 2002 Dec 05; 1(12):1017-26. Karanjawala ZE, Adachi N, Irvine RA, Oh EK, Shibata D, Schwarz K, Hsieh CL, Lieber MR. PMID: 12531011.
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    137. Bidirectional gene organization: a common architectural feature of the human genome. Cell. 2002 Jun 28; 109(7):807-9. Adachi N, Lieber MR. PMID: 12110178.
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    138. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell. 2002 Mar 22; 108(6):781-94. Ma Y, Pannicke U, Schwarz K, Lieber MR. PMID: 11955432.
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    139. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002 Mar 05; 12(5):397-402. Karanjawala ZE, Murphy N, Hinton DR, Hsieh CL, Lieber MR. PMID: 11882291.
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    140. Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs. J Biol Chem. 2002 Mar 29; 277(13):10756-9. Ma Y, Lieber MR. PMID: 11821378.
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    142. Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus. OMICS. 2002; 6(3):273-9. Adachi N, Karanjawala ZE, Matsuzaki Y, Koyama H, Lieber MR. PMID: 12427278.
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    144. Transcription-dependent R-loop formation at mammalian class switch sequences. EMBO J. 2001 Sep 01; 19(17):4855. Lieber M. PMID: 12134869.
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    146. Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection. EMBO J. 2001 Jun 15; 20(12):3272-81. Li L, Olvera JM, Yoder KE, Mitchell RS, Butler SL, Lieber M, Martin SL, Bushman FD. PMID: 11406603.
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    147. Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints. J Biol Chem. 2001 Aug 03; 276(31):29126-33. Raghavan SC, Kirsch IR, Lieber MR. PMID: 11390401.
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    148. Antibody diversity: a link between switching and hypermutation. Curr Biol. 2000 Nov 02; 10(21):R798-800. Lieber M. PMID: 11084354.
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    149. The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire. Mol Cell Biol. 2000 Nov; 20(21):7914-21. Yu K, Lieber MR. PMID: 11027262.
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    150. Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombination. Mol Cell Biol. 1999 Dec; 19(12):8094-102. Yu K, Lieber MR. PMID: 10567535.
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    151. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr Biol. 1999 Dec 16-30; 9(24):1501-4. Karanjawala ZE, Grawunder U, Hsieh CL, Lieber MR. PMID: 10607596.
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    152. Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway. J Biol Chem. 1999 Aug 13; 274(33):23599-609. Wilson TE, Lieber MR. PMID: 10438542.
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    153. A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1303-8. Wu X, Wilson TE, Lieber MR. PMID: 9990019.
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    154. The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. Genes Cells. 1999 Feb; 4(2):77-85. Lieber MR. PMID: 10320474.
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    155. The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step. Mol Cell Biol. 1998 Nov; 18(11):6408-15. West RB, Lieber MR. PMID: 9774656.
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    156. Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system. Am J Pathol. 1998 Nov; 153(5):1323-32. Lieber MR. PMID: 9811320.
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    157. Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini. Mol Cell Biol. 1998 Oct; 18(10):5908-20. West RB, Yaneva M, Lieber MR. PMID: 9742108.
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    158. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell. 1998 Oct; 2(4):477-84. Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR. PMID: 9809069.
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    159. Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo. J Biol Chem. 1998 Sep 18; 273(38):24708-14. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Grawunder U, Zimmer D, Kulesza P, Lieber MR. PMID: 9733770.
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    160. DNA-PK is essential only for coding joint formation in V(D)J recombination. Nucleic Acids Res. 1998 Sep 01; 26(17):3944-8. Kulesza P, Lieber MR. PMID: 9705502.
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    161. DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains. Curr Biol. 1998 Jul 16; 8(15):873-6. Grawunder U, Zimmer D, Lieber MR. PMID: 9705934.
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    162. Antigen receptor gene rearrangement. Curr Opin Immunol. 1998 Apr; 10(2):172-80. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Grawunder U, West RB, Lieber MR. PMID: 9602306.
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    163. V(D)J recombination activity in human hematopoietic cells: correlation with developmental stage and genome stability. Eur J Immunol. 1998 Jan; 28(1):351-8. Gauss GH, Domain I, Hsieh CL, Lieber MR. PMID: 9485214.
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    164. Interaction between DNA-dependent protein kinase and a novel protein, KIP. Mutat Res. 1997 Oct; 385(1):13-20. Wu X, Lieber MR. PMID: 9372844.
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    165. Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J. 1997 Aug 15; 16(16):5098-112. Yaneva M, Kowalewski T, Lieber MR. PMID: 9305651.
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    166. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature. 1997 Jul 31; 388(6641):492-5. Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M, Lieber MR. PMID: 9242410.
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    167. Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature. 1997 Jul 31; 388(6641):495-8. Wilson TE, Grawunder U, Lieber MR. PMID: 9242411.
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    168. A complex of RAG-1 and RAG-2 proteins persists on DNA after single-strand cleavage at V(D)J recombination signal sequences. Nucleic Acids Res. 1997 Apr 01; 25(7):1375-82. Grawunder U, Lieber MR. PMID: 9060432.
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    169. The role of recombination signal sequences in the preferential joining by deletion in DH-JH recombination and in the ordered rearrangement of the IgH locus. Int Immunol. 1997 Apr; 9(4):515-22. Pan PY, Lieber MR, Teale JM. PMID: 9138011.
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    170. The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair. Bioessays. 1997 Mar; 19(3):233-40. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Lieber MR. PMID: 9080773.
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    171. Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr Opin Genet Dev. 1997 Feb; 7(1):99-104. Lieber MR, Grawunder U, Wu X, Yaneva M. PMID: 9024627.
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    172. RAG mutations in human B cell-negative SCID. Science. 1996 Oct 04; 274(5284):97-9. Schwarz K, Gauss GH, Ludwig L, Pannicke U, Li Z, Lindner D, Friedrich W, Seger RA, Hansen-Hagge TE, Desiderio S, Lieber MR, Bartram CR. PMID: 8810255.
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    173. Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol Cell Biol. 1996 Sep; 16(9):5186-93. Wu X, Lieber MR. PMID: 8756676.
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    174. Asymmetric mutation around the recombination break point of immunoglobulin class switch sequences on extrachromosomal substrates. Nucleic Acids Res. 1996 Jun 01; 24(11):2104-11. Li J, Daniels GA, Lieber MR. PMID: 8668542.
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    175. Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA. Nucleic Acids Res. 1996 Jun 01; 24(11):2036-43. Wu X, Li J, Li X, Hsieh CL, Burgers PM, Lieber MR. PMID: 8668533.
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    176. Immunoglobulin diversity: rearranging by cutting and repairing. Curr Biol. 1996 Feb 01; 6(2):134-6. Lieber M. PMID: 8673457.
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    177. Mechanistic constraints on diversity in human V(D)J recombination. Mol Cell Biol. 1996 Jan; 16(1):258-69. Gauss GH, Lieber MR. PMID: 8524303.
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    178. Transcription targets recombination at immunoglobulin switch sequences in a strand-specific manner. Curr Top Microbiol Immunol. 1996; 217:171-89. Daniels GA, Lieber MR. PMID: 8787625.
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    179. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res. 1995 Dec 25; 23(24):5006-11. Daniels GA, Lieber MR. PMID: 8559658.
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    180. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol. 1995 Nov 15; 155(10):4529-33. Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH. PMID: 7594449.
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    181. Mechanistic properties of immunoglobulin somatic mutation. Ann N Y Acad Sci. 1995 Sep 29; 764:187-8. Ford JE, McHeyzer-Williams MG, Lieber MR. PMID: 7486520.
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    182. Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen. J Biol Chem. 1995 Sep 22; 270(38):22109-12. Li X, Li J, Harrington J, Lieber MR, Burgers PM. PMID: 7673186.
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    183. Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5625-9. Daniels GA, Lieber MR. PMID: 7777560.
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    184. The scid factor on human chromosome 8 restores V(D)J recombination in addition to double-strand break repair. Cancer Res. 1995 Apr 15; 55(8):1774-9. Komatsu K, Kubota N, Gallo M, Okumura Y, Lieber MR. PMID: 7712487.
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    185. DNA structural elements required for FEN-1 binding. J Biol Chem. 1995 Mar 03; 270(9):4503-8. Harrington JJ, Lieber MR. PMID: 7876218.
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    186. Treatment with finasteride following radical prostatectomy for prostate cancer. Urology. 1995 Mar; 45(3):491-7. Andriole G, Lieber M, Smith J, Soloway M, Schroeder F, Kadmon D, DeKernion J, Rajfer J, Boake R, Crawford D, et al. PMID: 7533461.
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    187. Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human. Genomics. 1995 Jan 01; 25(1):220-5. Hiraoka LR, Harrington JJ, Gerhard DS, Lieber MR, Hsieh CL. PMID: 7774922.
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    188. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science. 1994 Oct 14; 266(5183):288-91. Smider V, Rathmell WK, Lieber MR, Chu G. PMID: 7939667.
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    189. Distinct roles for RAG-1 in the initiation of V(D)J recombination and in the resolution of coding ends. J Biol Chem. 1994 Sep 02; 269(35):22188-92. Gallo ML, Pergola F, Daniels GA, Lieber MR. PMID: 8071342.
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    190. Analysis of individual immunoglobulin lambda light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation. Eur J Immunol. 1994 Aug; 24(8):1816-22. Ford JE, McHeyzer-Williams MG, Lieber MR. PMID: 8056040.
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    191. The mechanism of V(D)J recombination: site-specificity, reaction fidelity and immunologic diversity. Semin Immunol. 1994 Jun; 6(3):143-53. Lieber MR, Chang CP, Gallo M, Gauss G, Gerstein R, Islas A. PMID: 7948954.
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    192. Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Genes Dev. 1994 Jun 01; 8(11):1344-55. Harrington JJ, Lieber MR. PMID: 7926735.
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    193. Chimeric molecules created by gene amplification interfere with the analysis of somatic hypermutation of murine immunoglobulin genes. Gene. 1994 May 16; 142(2):279-83. Ford JE, McHeyzer-Williams MG, Lieber MR. PMID: 8194765.
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    194. Transcription, topoisomerases and recombination. Experientia. 1994 Mar 15; 50(3):261-9. Gangloff S, Lieber MR, Rothstein R. PMID: 8143800.
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    195. The characterization of a mammalian DNA structure-specific endonuclease. EMBO J. 1994 Mar 01; 13(5):1235-46. Harrington JJ, Lieber MR. PMID: 8131753.
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    196. V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem. 1993 Sep 25; 268(27):20105-9. Hsieh CL, Arlett CF, Lieber MR. PMID: 8397200.
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    197. Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev. 1993 Jul; 7(7B):1459-69. Gerstein RM, Lieber MR. PMID: 8330743.
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    198. Unequal signal and coding joint formation in human V(D)J recombination. Mol Cell Biol. 1993 Jul; 13(7):3900-6. Gauss GH, Lieber MR. PMID: 8321197.
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    199. Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination. Nature. 1993 Jun 17; 363(6430):625-7. Gerstein RM, Lieber MR. PMID: 8510753.
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    200. V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol Cell Biol. 1993 Jun; 13(6):3464-71. Pergola F, Zdzienicka MZ, Lieber MR. PMID: 8497262.
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    201. V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites. Mol Cell Biol. 1993 Mar; 13(3):1363-70. Sheehan KM, Lieber MR. PMID: 8441381.
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    202. Lymphoid V(D)J recombination. Functional analysis of the spacer sequence within the recombination signal. J Biol Chem. 1993 Feb 15; 268(5):3180-3. Wei Z, Lieber MR. PMID: 8428995.
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    203. DEAE-dextran enhances electroporation of mammalian cells. Nucleic Acids Res. 1992 Dec 25; 20(24):6739-40. Gauss GH, Lieber MR. PMID: 1480497.
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    204. Analysis of the defect in DNA end joining in the murine scid mutation. Mol Cell Biol. 1992 Oct; 12(10):4758-68. Harrington J, Hsieh CL, Gerton J, Bosma G, Lieber MR. PMID: 1406659.
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    205. The mechanism of V(D)J recombination: a balance of diversity, specificity, and stability. Cell. 1992 Sep 18; 70(6):873-6. Lieber MR. PMID: 1525825.
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    206. V(D)J recombination on minichromosomes is not affected by transcription. J Biol Chem. 1992 Aug 05; 267(22):15613-9. Hsieh CL, McCloskey RP, Lieber MR. PMID: 1639801.
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    207. The basis for the mechanistic bias for deletional over inversional V(D)J recombination. Genes Dev. 1992 Aug; 6(8):1553-61. Gauss GH, Lieber MR. PMID: 1644296.
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    208. Replication, transcription, CpG methylation and DNA topology in V(D)J recombination. Curr Top Microbiol Immunol. 1992; 182:125-35. Hsieh CL, Gauss G, Lieber MR. PMID: 1490346.
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    209. CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J. 1992 Jan; 11(1):315-25. Hsieh CL, Lieber MR. PMID: 1371250.
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    210. Site-specific recombination in the immune system. FASEB J. 1991 Nov; 5(14):2934-44. Lieber MR. PMID: 1752360.
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    211. V(D)J recombination: evidence that a replicative mechanism is not required. Mol Cell Biol. 1991 Aug; 11(8):3972-7. Hsieh CL, McCloskey RP, Radany E, Lieber MR. PMID: 2072902.
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    212. V(D)J recombination: a functional definition of the joining signals. Genes Dev. 1989 Jul; 3(7):1053-61. Hesse JE, Lieber MR, Mizuuchi K, Gellert M. PMID: 2777075.
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    213. Hemolytic holes in human erythrocyte membrane ghosts. Methods Enzymol. 1989; 173:356-67. Lieber MR, Steck TL. PMID: 2779432.
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    214. Abnormal V(D)J recombination in murine severe combined immune deficiency: absence of coding joints and formation of alternative products. Abnormal V(D)J recombination in murine severe combined immune deficiency: absence of coding joints and formation of alternative products. Curr Top Microbiol Immunol. 1989; 152:69-75. Lieber MR, Hesse JE, Lewis S, Bosma GC, Rosenberg N, Mizuuchi K, Bosma MJ, Gellert M. PMID: 2805799.
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    215. Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8588-92. Lieber MR, Hesse JE, Mizuuchi K, Gellert M. PMID: 2847166.
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    216. The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell. 1988 Oct 07; 55(1):7-16. Lieber MR, Hesse JE, Lewis S, Bosma GC, Rosenberg N, Mizuuchi K, Bosma MJ, Gellert M. PMID: 3167977.
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    217. Studies of V(D)J recombination with extrachromosomal substrates. Curr Top Microbiol Immunol. 1988; 137:94-9. Lieber MR, Hesse JE, Mizuuchi K, Gellert M. PMID: 3416646.
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    218. Developmental stage specificity of the lymphoid V(D)J recombination activity. Genes Dev. 1987 Oct; 1(8):751-61. Lieber MR, Hesse JE, Mizuuchi K, Gellert M. PMID: 3428598.
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    219. The mechanism of osmotic transfection of avian embryonic erythrocytes: analysis of a system for studying developmental gene expression. J Cell Biol. 1987 Sep; 105(3):1055-65. Lieber MR, Hesse JE, Nickol JM, Felsenfeld G. PMID: 3477547.
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    220. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell. 1987 Jun 19; 49(6):775-83. Hesse JE, Lieber MR, Gellert M, Mizuuchi K. PMID: 3495343.
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    221. DNA sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus. Nucleic Acids Res. 1984 Jun 25; 12(12):5005-13. Holbrook NJ, Lieber M, Crabtree GR. PMID: 6330695.
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    222. Lifespan changes in the index of cephalization. Exp Aging Res. 1984; 10(3):127-35. Lieber M, Blumenthal HT. PMID: 6519143.
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