Adam de Smith, PhD

Title(s)Assistant Professor of Population and Public Health Sciences
SchoolKeck School of Medicine of Usc
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
Emaildesmith@usc.edu
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    Collapse Biography 
    Collapse Education and Training
    Imperial College London, London, UKPhD10/2010Human genetic variation
    Imperial College London, London, UKMSc09/2006Human Molecular Genetics
    University of Bristol, Bristol, UKBSc06/2005Zoology

    Collapse Overview 
    Collapse Overview
    Adam de Smith is an Assistant Professor in the USC Center for Genetic Epidemiology in the Department of Population and Public Health Sciences, and is a member of the USC Norris Comprehensive Cancer Center. He is a genetic epidemiologist with a research focus on identifying the causes of acute lymphoblastic leukemia (ALL), the most common childhood cancer. Dr. de Smith leads studies investigating the role of common and rare genetic variants in ALL etiology, with a particular interest in elucidating the increased ALL risk in Latinos. He also leads a study of leukemia in children with Down syndrome, the International Study of Down Syndrome Acute Leukemia (IS-DSAL), investigating genetic and epigenetic variation associated with risk of DS-ALL. In addition, Dr. de Smith utilizes whole genome sequencing of tumors to examine potential causative agents, i.e. DNA mutational signatures as molecular footprints of environmental exposures.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children. Cell Genom. 2024 Apr 10; 4(4):100526. de Smith AJ, Wahlster L, Jeon S, Kachuri L, Black S, Langie J, Cato LD, Nakatsuka N, Chan TF, Xia G, Mazumder S, Yang W, Gazal S, Eng C, Hu D, Burchard EG, Ziv E, Metayer C, Mancuso N, Yang JJ, Ma X, Wiemels JL, Wiemels JL, Yu F, Chiang CWK, Sankaran VG. PMID: 38537633; PMCID: PMC11019360.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Backtracking to the future: unraveling the origins of childhood leukemia. Leukemia. 2024 02; 38(2):416-419. de Smith AJ, Wiemels JL, Wiemels JL, Mead AJ, Roberts I, Roy A, Spector LG. PMID: 38123697; PMCID: PMC11092887.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men. Hum Mol Genet. 2023 01 13; 32(3):489-495. Wang A, Xu Y, Yu Y, Nead KT, Kim T, Xu K, Dadaev T, Saunders E, Sheng X, Wan P, Pooler L, Xia LY, Chanock S, Berndt SI, Gapstur SM, Stevens V, Albanes D, Weinstein SJ, Gnanapragasam V, Giles GG, Nguyen-Dumont T, Milne RL, Pomerantz MM, Schmidt JA, Stopsack KH, Mucci LA, Catalona WJ, Hetrick KN, Doheny KF, MacInnis RJ, Southey MC, Eeles RA, Wiklund F, Kote-Jarai Z, de Smith AJ, Conti DV, Huff C, Haiman CA, Darst BF. PMID: 36018819; PMCID: PMC9851740.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Periconceptional folate intake influences DNA methylation at birth based on dietary source in an analysis of pediatric acute lymphoblastic leukemia cases and controls. Am J Clin Nutr. 2022 12 19; 116(6):1553-1564. Nickels EM, Li S, Morimoto L, Kang AY, de Smith AJ, Metayer C, Wiemels JL, Wiemels JL. PMID: 36178055; PMCID: PMC9761733.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia. Hum Mol Genet. 2022 10 28; 31(21):3741-3756. Xu K, Li S, Pandey P, Kang AY, Morimoto LM, Mancuso N, Ma X, Metayer C, Wiemels JL, Wiemels JL, de Smith AJ. PMID: 35717575; PMCID: PMC9616572.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Associations between early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children. Int J Cancer. 2023 03 01; 152(5):845-853. Gallant RE, Arroyo K, Metayer C, Kang AY, de Smith AJ, Wiemels JL, Wiemels JL. PMID: 36104937; PMCID: PMC10092298.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study. Cancer Res. 2022 Sep 16; 82(18):3201-3208. Chen F, Park SL, Wilkens LR, Wan P, Hart SN, Hu C, Yadav S, Couch FJ, Conti DV, de Smith AJ, Haiman CA. PMID: 35834270; PMCID: PMC9481694.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children. PLoS Genet. 2022 09; 18(9):e1010388. Li S, Chiang CWK, Myint SS, Arroyo K, Chan TF, Morimoto L, Metayer C, de Smith AJ, Walsh KM, Wiemels JL, Wiemels JL. PMID: 36070312; PMCID: PMC9484652.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children. Haematologica. 2022 09 01; 107(9):2266-2270. Wiemels JL, Wiemels JL, Wang R, Zhou M, Hansen H, Gallant R, Jung J, Mancuso N, De Smith AJ, Metayer C, Kogan SC, Ma X. PMID: 35638549; PMCID: PMC9425315.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome. Blood Adv. 2022 07 26; 6(14):4132-4136. Li S, Sok P, Xu K, Muskens IS, Elliott N, Myint SS, Pandey P, Hansen HM, Morimoto LM, Kang AY, Metayer C, Ma X, Mueller BA, Roy A, Roberts I, Rabin KR, Brown AL, Lupo PJ, Wiemels JL, Wiemels JL, de Smith AJ. PMID: 35588500; PMCID: PMC9327551.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. Nat Biotechnol. 2022 12; 40(12):1834-1844. Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. PMID: 35879364; PMCID: PMC9750872.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL. Blood Adv. 2022 06 28; 6(12):3756-3766. Feng Q, Zhou M, Li S, Morimoto L, Hansen H, Myint SS, Wang R, Metayer C, Kang A, Fear AL, Pappas D, Erlich H, Hollenbach JA, Mancuso N, Trachtenberg E, de Smith AJ, Ma X, Wiemels JL, Wiemels JL. PMID: 35500222; PMCID: PMC9631572.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Variant to function mapping at single-cell resolution through network propagation. Nat Biotechnol. 2022 11; 40(11):1644-1653. Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG. PMID: 35668323; PMCID: PMC9646486.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    14. Accelerated epigenetic aging in newborns with Down syndrome. Aging Cell. 2022 07; 21(7):e13652. Xu K, Li S, Muskens IS, Elliott N, Myint SS, Pandey P, Hansen HM, Morimoto LM, Kang AY, Ma X, Metayer C, Mueller BA, Roberts I, Walsh KM, Horvath S, Wiemels JL, Wiemels JL, de Smith AJ. PMID: 35661546; PMCID: PMC9282838.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. Mitochondrial 1555 G>A variant as a potential risk factor for childhood glioblastoma. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac045. Li S, Gai X, Myint SS, Arroyo K, Morimoto L, Metayer C, de Smith AJ, Walsh KM, Wiemels JL, Wiemels JL. PMID: 35571988; PMCID: PMC9092641.
      View in: PubMed   Mentions: 2  
    16. Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis. Am J Hematol. 2022 06 01; 97(6):E198-E201. Gallant RE, Arroyo K, Bracci PM, Li S, Metayer C, Kogan SC, Wendt GA, Francis SS, de Smith AJ, Wiemels JL, Wiemels JL. PMID: 35285969.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Development of a Droplet Digital™ PCR DNA methylation detection and quantification assay of prenatal tobacco exposure. Biotechniques. 2022 04; 72(4):121-133. Arroyo K, Nargizyan A, Andrade FG, Myint SS, Lu S, Pandey P, Yee A, de Smith AJ, Wiemels JL, Wiemels JL. PMID: 35255733.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Variant to function mapping at single-cell resolution through network propagation. bioRxiv. 2022 Jan 24. Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG. PMID: 35118467; PMCID: PMC8811900.
      View in: PubMed   Mentions:
    19. Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia. Leukemia. 2022 03; 36(3):865-868. Jeon S, de Smith AJ, Li S, Chen M, Chan TF, Muskens IS, Morimoto LM, DeWan AT, Mancuso N, Metayer C, Ma X, Wiemels JL, Wiemels JL, Chiang CWK. PMID: 34750507; PMCID: PMC9075725.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    20. Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia. Am J Hum Genet. 2021 10 07; 108(10):1823-1835. Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, Wiemels JL, de Smith AJ. PMID: 34469753; PMCID: PMC8546033.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    21. Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples. Leukemia. 2022 01; 36(1):279-282. Behnert A, Meyer J, Parsa JY, Hechmer A, Loh ML, Olshen A, de Smith AJ, Stieglitz E. PMID: 34183765; PMCID: PMC8720242.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsPHPublic Health
    22. Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites. Elife. 2021 06 22; 10. Feng Q, Nickels E, Muskens IS, de Smith AJ, Gauderman WJ, Yee AC, Ricker C, Mack T, Leavitt AD, Godley LA, Wiemels JL, Wiemels JL. PMID: 34155975; PMCID: PMC8219377.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1517-1525. Xu K, Li S, Whitehead TP, Pandey P, Kang AY, Morimoto LM, Kogan SC, Metayer C, Wiemels JL, Wiemels JL, de Smith AJ. PMID: 34020997; PMCID: PMC8338876.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsPHPublic Health
    24. In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system. Clin Sci (Lond). 2021 04 30; 135(8):1053-1063. Snijders AM, Zhou M, Whitehead TP, Fitch B, Pandey P, Hechmer A, Huang A, Schick SF, de Smith AJ, Olshen AB, Metayer C, Mao JH, Wiemels JL, Wiemels JL, Kogan SC. PMID: 33851706; PMCID: PMC8086195.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsPHPublic Health
    25. Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016. Am J Epidemiol. 2021 04 06; 190(4):519-527. Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL, Wiemels JL. PMID: 33034340.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    26. The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis. Nat Commun. 2021 02 05; 12(1):821. Muskens IS, Li S, Jackson T, Elliot N, Hansen HM, Myint SS, Pandey P, Schraw JM, Roy R, Anguiano J, Goudevenou K, Siegmund KD, Lupo PJ, de Bruijn MFTR, Walsh KM, Vyas P, Ma X, Roy A, Roberts I, Wiemels JL, Wiemels JL, de Smith AJ. PMID: 33547282; PMCID: PMC7865055.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    27. European genetic ancestry associated with risk of childhood ependymoma. Neuro Oncol. 2020 11 26; 22(11):1637-1646. Zhang C, Ostrom QT, Hansen HM, Gonzalez-Maya J, Hu D, Ziv E, Morimoto L, de Smith AJ, Muskens IS, Kline CN, Vaksman Z, Hakonarson H, Diskin SJ, Kruchko C, Barnholtz-Sloan JS, Ramaswamy V, Ali-Osman F, Bondy ML, Taylor MD, Metayer C, Wiemels JL, Wiemels JL, Walsh KM. PMID: 32607579; PMCID: PMC7846152.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    28. Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma. Acta Neuropathol Commun. 2020 10 28; 8(1):173. Zhang C, Ostrom QT, Semmes EC, Ramaswamy V, Hansen HM, Morimoto L, de Smith AJ, Pekmezci M, Vaksman Z, Hakonarson H, Diskin SJ, Metayer C, Glioma International Case-Control Study (GICC), Taylor MD, Wiemels JL, Wiemels JL, Bondy ML, Walsh KM. PMID: 33115534; PMCID: PMC7592366.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    29. History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System. Am J Epidemiol. 2020 10 01; 189(10):1076-1085. Morimoto LM, Kwan ML, Deosaransingh K, Munneke JR, Kang AY, Quesenberry C, Kogan S, de Smith AJ, Metayer C, Wiemels JL, Wiemels JL. PMID: 32322901; PMCID: PMC7670873.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Cancer health disparities in racial/ethnic minorities in the United States. Br J Cancer. 2021 01; 124(2):315-332. Zavala VA, Bracci PM, Carethers JM, Carvajal-Carmona L, Coggins NB, Cruz-Correa MR, Davis M, de Smith AJ, Dutil J, Figueiredo JC, Fox R, Graves KD, Gomez SL, Llera A, Neuhausen SL, Newman L, Nguyen T, Palmer JR, Palmer NR, Pérez-Stable EJ, Piawah S, Rodriquez EJ, Sanabria-Salas MC, Schmit SL, Serrano-Gomez SJ, Stern MC, Weitzel J, Yang JJ, Zabaleta J, Ziv E, Fejerman L. PMID: 32901135; PMCID: PMC7852513.
      View in: PubMed   Mentions: 322     Fields:    Translation:Humans
    31. Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa089. Muskens IS, Feng Q, Francis SS, Walsh KM, Mckean-Cowdin R, Gauderman WJ, de Smith AJ, Wiemels JL, Wiemels JL. PMID: 32864610; PMCID: PMC7447139.
      View in: PubMed   Mentions: 6  
    32. Germline cancer predisposition variants and pediatric glioma: a population-based study in California. Neuro Oncol. 2020 06 09; 22(6):864-874. Muskens IS, de Smith AJ, Zhang C, Hansen HM, Morimoto L, Metayer C, Ma X, Walsh KM, Wiemels JL, Wiemels JL. PMID: 31970404; PMCID: PMC7283023.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    33. Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia. Blood Adv. 2020 02 25; 4(4):672-675. Winer P, Muskens IS, Walsh KM, Vora A, Moorman AV, Wiemels JL, Wiemels JL, Roberts I, Roy A, de Smith AJ. PMID: 32084258; PMCID: PMC7042982.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    34. Germline genetic landscape of pediatric central nervous system tumors. Neuro Oncol. 2019 11 04; 21(11):1376-1388. Muskens IS, Zhang C, de Smith AJ, Biegel JA, Walsh KM, Wiemels JL, Wiemels JL. PMID: 31247102; PMCID: PMC6827836.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    35. Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome. Blood. 2019 10 10; 134(15):1227-1237. Brown AL, de Smith AJ, Gant VU, Yang W, Scheurer ME, Walsh KM, Chernus JM, Kallsen NA, Peyton SA, Davies GE, Ehli EA, Winick N, Heerema NA, Carroll AJ, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, Feingold E, Devidas M, Barcellos LF, Hansen HM, Morimoto L, Kang AY, Smirnov I, Healy J, Laverdière C, Sinnett D, Taub JW, Birch JM, Thompson P, Spector LG, Pombo-de-Oliveira MS, DeWan AT, Mullighan CG, Hunger SP, Pui CH, Loh ML, Zwick ME, Metayer C, Ma X, Mueller BA, Sherman SL, Wiemels JL, Wiemels JL, Relling MV, Yang JJ, Lupo PJ, Rabin KR. PMID: 31350265; PMCID: PMC6788009.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    36. Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population. Bone. 2020 01; 130:115070. Zhang C, Hansen HM, Semmes EC, Gonzalez-Maya J, Morimoto L, Wei Q, Eward WC, DeWitt SB, Hurst JH, Metayer C, de Smith AJ, Wiemels JL, Wiemels JL, Walsh KM. PMID: 31525475; PMCID: PMC6885126.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    37. Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome. Leukemia. 2019 11; 33(11):2746-2751. de Smith AJ, Walsh KM, Morimoto LM, Francis SS, Hansen HM, Jeon S, Gonseth S, Chen M, Sun H, Luna-Fineman S, Antillón F, Girón V, Kang AY, Smirnov I, Shao X, Whitehead TP, Barcellos LF, Jolly KW, Healy J, Laverdière C, Sinnett D, Taub JW, Birch JM, Thompson PD, Pombo-de-Oliveira MS, Spector LG, DeWan AT, Mueller BA, Chiang C, Metayer C, Ma X, Wiemels JL, Wiemels JL. PMID: 31296947; PMCID: PMC6858994.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    38. Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children. Genes Chromosomes Cancer. 2019 10; 58(10):723-730. de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JL, Wiemels JL. PMID: 31102422; PMCID: PMC6684857.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology. Haematologica. 2019 11; 104(11):e514-e516. Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL, Wiemels JL. PMID: 30923090; PMCID: PMC6821599.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    40. BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia. Int J Cancer. 2018 12 01; 143(11):2647-2658. de Smith AJ, Walsh KM, Francis SS, Zhang C, Hansen HM, Smirnov I, Morimoto L, Whitehead TP, Kang A, Shao X, Barcellos LF, McKean-Cowdin R, Zhang L, Fu C, Wang R, Yu H, Hoh J, Dewan AT, Metayer C, Ma X, Wiemels JL, Wiemels JL. PMID: 29923177; PMCID: PMC6235695.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    41. Genetic determinants of childhood and adult height associated with osteosarcoma risk. Cancer. 2018 09 15; 124(18):3742-3752. Zhang C, Morimoto LM, de Smith AJ, Hansen HM, Gonzalez-Maya J, Endicott AA, Smirnov IV, Metayer C, Wei Q, Eward WC, Wiemels JL, Wiemels JL, Walsh KM. PMID: 30311632; PMCID: PMC6214707.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansPHPublic Health
    42. To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes. Front Genet. 2018; 9:298. Wallace AD, Wendt GA, Barcellos LF, de Smith AJ, Walsh KM, Metayer C, Costello JF, Wiemels JL, Wiemels JL, Francis SS. PMID: 30154825; PMCID: PMC6102640.
      View in: PubMed   Mentions: 20  
    43. Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk. Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1151-1158. Zhang C, Wiemels JL, Wiemels JL, Hansen HM, Gonzalez-Maya J, Endicott AA, de Smith AJ, Smirnov IV, Witte JS, Morimoto LM, Metayer C, Walsh KM. PMID: 30038050; PMCID: PMC6170682.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    44. Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers. Environ Health. 2018 05 02; 17(1):43. Ojha J, Dyagil I, Finch SC, Reiss RF, de Smith AJ, Gonseth S, Zhou M, Hansen HM, Sherborne AL, Nakamura J, Bracci PM, Gudzenko N, Hatch M, Babkina N, Little MP, Chumak VV, Walsh KM, Bazyka D, Wiemels JL, Wiemels JL, Zablotska LB. PMID: 29720177; PMCID: PMC5930419.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    45. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun. 2018 01 18; 9(1):286. Wiemels JL, Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. PMID: 29348612; PMCID: PMC5773513.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    46. A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology. Haematologica. 2018 01; 103(1):e29-e31. Wallace AD, Francis SS, Shao X, de Smith AJ, Walsh KM, Mckean-Cowdin R, Ma X, Dahl G, Barcellos LF, Wiemels JL, Wiemels JL, Metayer C. PMID: 29025908; PMCID: PMC5777211.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    47. Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma. J Neurooncol. 2017 Nov; 135(2):237-244. Zhang C, de Smith AJ, Smirnov IV, Wiencke JK, Wiemels JL, Wiemels JL, Witte JS, Walsh KM. PMID: 28721485; PMCID: PMC5665694.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    48. Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Res. 2017 04 01; 77(7):1674-1683. de Smith AJ, Kaur M, Gonseth S, Endicott A, Selvin S, Zhang L, Roy R, Shao X, Hansen HM, Kang AY, Walsh KM, Dahl GV, McKean-Cowdin R, Metayer C, Wiemels JL, Wiemels JL. PMID: 28202519; PMCID: PMC5380517.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsPHPublic Health
    49. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood. 2017 03 23; 129(12):1680-1684. Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL, Wiemels JL. PMID: 27979823; PMCID: PMC5364339.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansPHPublic Health
    50. Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget. 2016 Nov 08; 7(45):72733-72745. de Smith AJ, Ojha J, Francis SS, Sanders E, Endicott AA, Hansen HM, Smirnov I, Termuhlen AM, Walsh KM, Metayer C, Wiemels JL, Wiemels JL. PMID: 27683039; PMCID: PMC5341940.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    51. Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia. Arch Med Res. 2016 11; 47(8):677-683. Kaur M, de Smith AJ, Selvin S, Zhang L, Cunningham M, Kang MW, Hansen HM, Cooper RM, McKean-Cowdin R, Wiemels JL, Wiemels JL, Metayer C. PMID: 28476195; PMCID: PMC5424620.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    52. Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. Epigenetics. 2016 09; 11(9):664-673. Gonseth S, de Smith AJ, Roy R, Zhou M, Lee ST, Shao X, Ohja J, Wrensch MR, Walsh KM, Metayer C, Wiemels JL, Wiemels JL. PMID: 27403598; PMCID: PMC5048731.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    53. Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia. Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1043-9. Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith AJ, Bracci PM, Wiencke JK, Wrensch MR, Wiemels JL, Wiemels JL, Walsh KM, ENGAGE Consortium Telomere Group. PMID: 27197291; PMCID: PMC5008454.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    54. Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. Carcinogenesis. 2016 06; 37(6):576-582. Walsh KM, Whitehead TP, de Smith AJ, Smirnov IV, Park M, Endicott AA, Francis SS, Codd V, ENGAGE Consortium Telomere Group, Samani NJ, Metayer C, Wiemels JL, Wiemels JL. PMID: 27207662; PMCID: PMC4876988.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    55. Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases. Neuropathol Appl Neurobiol. 2016 08; 42(5):436-50. Ruffmann C, Calboli FC, Bravi I, Gveric D, Curry LK, de Smith A, Pavlou S, Buxton JL, Blakemore AI, Takousis P, Molloy S, Piccini P, Dexter DT, Roncaroli F, Gentleman SM, Middleton LT. PMID: 26527105.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    56. Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. PLoS One. 2015; 10(11):e0143343. de Smith AJ, Walsh KM, Hansen HM, Endicott AA, Wiencke JK, Metayer C, Wiemels JL, Wiemels JL. PMID: 26575185; PMCID: PMC4648491.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    57. A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution. Cancer Res. 2015 Nov 15; 75(22):4884-94. Walsh KM, de Smith AJ, Hansen HM, Smirnov IV, Gonseth S, Endicott AA, Xiao J, Rice T, Fu CH, McCoy LS, Lachance DH, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR, Ma X, Metayer C, Wiemels JL, Wiemels JL. PMID: 26527286; PMCID: PMC4651745.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    58. A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros. Leukemia. 2016 05; 30(5):1194-7. Wiemels JL, Wiemels JL, de Smith AJ, Xiao J, Lee ST, Muench MO, Fomin ME, Zhou M, Hansen HM, Termuhlen A, Metayer C, Walsh KM. PMID: 26437776; PMCID: PMC4794412.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    59. PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium. Nat Commun. 2015 May 18; 6:6930. Noseda M, Harada M, McSweeney S, Leja T, Belian E, Stuckey DJ, Abreu Paiva MS, Habib J, Macaulay I, de Smith AJ, al-Beidh F, Sampson R, Lumbers RT, Rao P, Harding SE, Blakemore AI, Jacobsen SE, Barahona M, Schneider MD. PMID: 25980517; PMCID: PMC4479024.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    60. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602. Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL, Wiemels JL. PMID: 25690899; PMCID: PMC4357708.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    61. Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes. Epigenetics. 2015; 10(12):1166-76. Gonseth S, Roy R, Houseman EA, de Smith AJ, Zhou M, Lee ST, Nusslé S, Singer AW, Wrensch MR, Metayer C, Wiemels JL, Wiemels JL. PMID: 26646725; PMCID: PMC4844202.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    62. Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia. Am J Hematol. 2014 Jul; 89(7):721-5. Walsh KM, de Smith AJ, Welch TC, Smirnov I, Cunningham MJ, Ma X, Chokkalingam AP, Dahl GV, Roberts W, Barcellos LF, Buffler PA, Metayer C, Wiemels JL, Wiemels JL. PMID: 24753091; PMCID: PMC4069235.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    63. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer. 2014 Sep 01; 135(5):1101-9. Xiao J, Lee ST, Xiao Y, Ma X, Houseman EA, Hsu LI, Roy R, Wrensch M, de Smith AJ, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL, Wiemels JL. PMID: 24496747; PMCID: PMC4776754.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    64. The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood. 2014 Apr 17; 123(16):2497-503. de Smith AJ, Walsh KM, Ladner MB, Zhang S, Xiao C, Cohen F, Moore TB, Chokkalingam AP, Metayer C, Buffler PA, Trachtenberg EA, Wiemels JL, Wiemels JL. PMID: 24518758; PMCID: PMC3990912.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    65. Imprinted expression of UBE3A in non-neuronal cells from a Prader-Willi syndrome patient with an atypical deletion. Hum Mol Genet. 2014 May 01; 23(9):2364-73. Martins-Taylor K, Hsiao JS, Chen PF, Glatt-Deeley H, De Smith AJ, Blakemore AI, Lalande M, Chamberlain SJ. PMID: 24363065; PMCID: PMC3976333.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    66. GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL. Blood. 2013 Nov 07; 122(19):3385-7. Walsh KM, de Smith AJ, Chokkalingam AP, Metayer C, Roberts W, Barcellos LF, Wiemels JL, Wiemels JL, Buffler PA. PMID: 24203929; PMCID: PMC3821727.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    67. Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype. Blood. 2013 Jun 06; 121(23):4808-9. Walsh KM, de Smith AJ, Chokkalingam AP, Metayer C, Dahl GV, Hsu LI, Barcellos LF, Wiemels JL, Wiemels JL, Buffler PA. PMID: 23744494; PMCID: PMC3674678.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    68. Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children. Leukemia. 2013 Dec; 27(12):2416-9. Walsh KM, Chokkalingam AP, Hsu LI, Metayer C, de Smith AJ, Jacobs DI, Dahl GV, Loh ML, Smirnov IV, Bartley K, Ma X, Wiencke JK, Barcellos LF, Wiemels JL, Wiemels JL, Buffler PA. PMID: 23615557; PMCID: PMC3864612.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    69. Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. PLoS One. 2013; 8(3):e58048. Walters RG, Coin LJ, Ruokonen A, de Smith AJ, El-Sayed Moustafa JS, Jacquemont S, Elliott P, Esko T, Hartikainen AL, Laitinen J, Männik K, Martinet D, Meyre D, Nauck M, Schurmann C, Sladek R, Thorleifsson G, Thorsteinsdóttir U, Valsesia A, Waeber G, Zufferey F, Balkau B, Pattou F, Metspalu A, Völzke H, Vollenweider P, Stefansson K, Järvelin MR, Beckmann JS, Froguel P, Blakemore AI. PMID: 23554873; PMCID: PMC3595275.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    70. A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res. 2012 Dec; 40(22):11339-51. Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, Zheng S, Dou X, de Smith A, Chokkalingam A, Buffler P, Ma X, Wiemels JL, Wiemels JL. PMID: 23074194; PMCID: PMC3526268.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    71. Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity. Hum Mol Genet. 2012 Aug 15; 21(16):3727-38. El-Sayed Moustafa JS, Eleftherohorinou H, de Smith AJ, Andersson-Assarsson JC, Alves AC, Hadjigeorgiou E, Walters RG, Asher JE, Bottolo L, Buxton JL, Sladek R, Meyre D, Dina C, Visvikis-Siest S, Jacobson P, Sjöström L, Carlsson LM, Walley A, Falchi M, Froguel P, Blakemore AI, Coin LJ. PMID: 22595969; PMCID: PMC3406755.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    72. Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nat Biotechnol. 2011 Jul 24; 29(8):723-30. Li Y, Zheng H, Luo R, Wu H, Zhu H, Li R, Cao H, Wu B, Huang S, Shao H, Ma H, Zhang F, Feng S, Zhang W, Du H, Tian G, Li J, Zhang X, Li S, Bolund L, Kristiansen K, de Smith AJ, Blakemore AI, Coin LJ, Yang H, Wang J, Wang J. PMID: 21785424.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    73. Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry. Clin Chem. 2011 Aug; 57(8):1188-95. Trewick AL, Moustafa JS, de Smith AJ, Froguel P, Greve G, Njølstad PR, Coin LJ, Blakemore AI. PMID: 21677093.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    74. Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. Am J Med Genet A. 2011 May; 155A(5):1192-5. de Smith AJ, van Haelst MM, Ellis RJ, Holder SE, Payne SJ, Hashim SK, Froguel P, Blakemore AI. PMID: 21465662.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    75. Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants. Ann Hum Genet. 2011 May; 75(3):383-97. Fernando MM, de Smith AJ, Coin L, Morris DL, Froguel P, Mangion J, Blakemore AI, Graham RR, Behrens TW, Vyse TJ. PMID: 21401563.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    76. Implications of copy number variation in people with chromosomal abnormalities: potential for greater variation in copy number state may contribute to variability of phenotype. Hugo J. 2010 Dec; 4(1-4):1-9. de Smith AJ, Trewick AL, Blakemore AI. PMID: 22132061; PMCID: PMC3051043.
      View in: PubMed   Mentions: 8  
    77. cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs. Nat Methods. 2010 Jul; 7(7):541-6. Coin LJ, Asher JE, Walters RG, Moustafa JS, de Smith AJ, Sladek R, Balding DJ, Froguel P, Blakemore AI. PMID: 20512141.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    78. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature. 2010 Feb 04; 463(7281):671-5. Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, Delobel B, Stutzmann F, El-Sayed Moustafa JS, Chèvre JC, Lecoeur C, Vatin V, Bouquillon S, Buxton JL, Boute O, Holder-Espinasse M, Cuisset JM, Lemaitre MP, Ambresin AE, Brioschi A, Gaillard M, Giusti V, Fellmann F, Ferrarini A, Hadjikhani N, Campion D, Guilmatre A, Goldenberg A, Calmels N, Mandel JL, Le Caignec C, David A, Isidor B, Cordier MP, Dupuis-Girod S, Labalme A, Sanlaville D, Béri-Dexheimer M, Jonveaux P, Leheup B, Ounap K, Bochukova EG, Henning E, Keogh J, Ellis RJ, Macdermot KD, van Haelst MM, Vincent-Delorme C, Plessis G, Touraine R, Philippe A, Malan V, Mathieu-Dramard M, Chiesa J, Blaumeiser B, Kooy RF, Caiazzo R, Pigeyre M, Balkau B, Sladek R, Bergmann S, Mooser V, Waterworth D, Reymond A, Vollenweider P, Waeber G, Kurg A, Palta P, Esko T, Metspalu A, Nelis M, Elliott P, Hartikainen AL, McCarthy MI, Peltonen L, Carlsson L, Jacobson P, Sjöström L, Huang N, Hurles ME, O'Rahilly S, Farooqi IS, Männik K, Jarvelin MR, Pattou F, Meyre D, Walley AJ, Coin LJ, Blakemore AI, Froguel P, Beckmann JS. PMID: 20130649; PMCID: PMC2880448.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansCells
    79. A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Hum Mol Genet. 2009 Sep 01; 18(17):3257-65. de Smith AJ, Purmann C, Walters RG, Ellis RJ, Holder SE, Van Haelst MM, Brady AF, Fairbrother UL, Dattani M, Keogh JM, Henning E, Yeo GS, O'Rahilly S, Froguel P, Farooqi IS, Blakemore AI. PMID: 19498035; PMCID: PMC2722987.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    80. Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease. Cytogenet Genome Res. 2008; 123(1-4):17-26. de Smith AJ, Walters RG, Froguel P, Blakemore AI. PMID: 19287135; PMCID: PMC2920180.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    81. Small deletion variants have stable breakpoints commonly associated with alu elements. PLoS One. 2008 Aug 29; 3(8):e3104. de Smith AJ, Walters RG, Coin LJ, Steinfeld I, Yakhini Z, Sladek R, Froguel P, Blakemore AI. PMID: 18769679; PMCID: PMC2518860.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    82. Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Hum Mol Genet. 2007 Dec 01; 16(23):2783-94. de Smith AJ, Tsalenko A, Sampas N, Scheffer A, Yamada NA, Tsang P, Ben-Dor A, Yakhini Z, Ellis RJ, Bruhn L, Laderman S, Froguel P, Blakemore AI. PMID: 17666407.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    83. FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet. 2007 Jun; 39(6):721-3. Fanciulli M, Norsworthy PJ, Petretto E, Dong R, Harper L, Kamesh L, Heward JM, Gough SC, de Smith A, Blakemore AI, Froguel P, Owen CJ, Pearce SH, Teixeira L, Guillevin L, Graham DS, Pusey CD, Cook HT, Vyse TJ, Aitman TJ. PMID: 17529978; PMCID: PMC2742197.
      View in: PubMed   Mentions: 206     Fields:    Translation:Humans
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