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Adam de Smith

TitleAssistant Professor of Clinical Preventive Medicine
InstitutionUniversity of Southern California
DepartmentCenter for Genetic Epidemiology
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang C, Wiemels JL, Hansen HM, Gonzalez-Maya J, Endicott AA, de Smith A, Smirnov IV, Witte JS, Morimoto LM, Metayer C, Walsh KM. Two HLA class II gene variants are independently associated with pediatric osteosarcoma risk. Cancer Epidemiol Biomarkers Prev. 2018 Jul 23. PMID: 30038050.
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    2. de Smith A, Walsh KM, Francis SS, Zhang C, Hansen HM, Smirnov I, Morimoto L, Whitehead TP, Kang A, Shao X, Barcellos LF, McKean-Cowdin R, Zhang L, Fu C, Wang R, Yu H, Hoh J, Dewan AT, Metayer C, Ma X, Wiemels JL. BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia. Int J Cancer. 2018 Jun 19. PMID: 29923177.
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    3. Ojha J, Dyagil I, Finch SC, Reiss RF, de Smith A, Gonseth S, Zhou M, Hansen HM, Sherborne AL, Nakamura J, Bracci PM, Gudzenko N, Hatch M, Babkina N, Little MP, Chumak VV, Walsh KM, Bazyka D, Wiemels JL, Zablotska LB. Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers. Environ Health. 2018 May 02; 17(1):43. PMID: 29720177.
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    4. Wiemels JL, Walsh KM, de Smith A, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun. 2018 01 18; 9(1):286. PMID: 29348612.
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    5. Wallace AD, Francis SS, Shao X, de Smith A, Walsh KM, Mckean-Cowdin R, Ma X, Dahl G, Barcellos LF, Wiemels JL, Metayer C. A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology. Haematologica. 2018 Jan; 103(1):e29-e31. PMID: 29025908.
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    6. Zhang C, de Smith A, Smirnov IV, Wiencke JK, Wiemels JL, Witte JS, Walsh KM. Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma. J Neurooncol. 2017 Nov; 135(2):237-244. PMID: 28721485.
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    7. de Smith A, Kaur M, Gonseth S, Endicott A, Selvin S, Zhang L, Roy R, Shao X, Hansen HM, Kang AY, Walsh KM, Dahl GV, McKean-Cowdin R, Metayer C, Wiemels JL. Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Res. 2017 04 01; 77(7):1674-1683. PMID: 28202519.
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    8. Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith A, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood. 2017 03 23; 129(12):1680-1684. PMID: 27979823.
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    9. de Smith A, Ojha J, Francis SS, Sanders E, Endicott AA, Hansen HM, Smirnov I, Termuhlen AM, Walsh KM, Metayer C, Wiemels JL. Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget. 2016 Nov 08; 7(45):72733-72745. PMID: 27683039.
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    10. Kaur M, de Smith A, Selvin S, Zhang L, Cunningham M, Kang MW, Hansen HM, Cooper RM, McKean-Cowdin R, Wiemels JL, Metayer C. Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia. Arch Med Res. 2016 Nov; 47(8):677-683. PMID: 28476195.
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    11. Gonseth S, de Smith A, Roy R, Zhou M, Lee ST, Shao X, Ohja J, Wrensch MR, Walsh KM, Metayer C, Wiemels JL. Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. Epigenetics. 2016 09; 11(9):664-673. PMID: 27403598.
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    12. Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith A, Bracci PM, Wiencke JK, Wrensch MR, Wiemels JL, Walsh KM. Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia. Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1043-9. PMID: 27197291; PMCID: PMC5008454 [Available on 07/01/17].
    13. Walsh KM, Whitehead TP, de Smith A, Smirnov IV, Park M, Endicott AA, Francis SS, Codd V. Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. Carcinogenesis. 2016 06; 37(6):576-582. PMID: 27207662.
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    14. Ruffmann C, Calboli FC, Bravi I, Gveric D, Curry LK, de Smith A, Pavlou S, Buxton JL, Blakemore AI, Takousis P, Molloy S, Piccini P, Dexter DT, Roncaroli F, Gentleman SM, Middleton LT. Cortical Lewy bodies and Aß burden are associated with prevalence and timing of dementia in Lewy body diseases. Neuropathol Appl Neurobiol. 2016 08; 42(5):436-50. PMID: 26527105.
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    15. de Smith A, Walsh KM, Hansen HM, Endicott AA, Wiencke JK, Metayer C, Wiemels JL. Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. PLoS One. 2015; 10(11):e0143343. PMID: 26575185; PMCID: PMC4648491.
    16. Walsh KM, de Smith A, Hansen HM, Smirnov IV, Gonseth S, Endicott AA, Xiao J, Rice T, Fu CH, McCoy LS, Lachance DH, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR, Ma X, Metayer C, Wiemels JL. A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution. Cancer Res. 2015 Nov 15; 75(22):4884-94. PMID: 26527286.
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    17. Wiemels JL, de Smith A, Xiao J, Lee ST, Muench MO, Fomin ME, Zhou M, Hansen HM, Termuhlen A, Metayer C, Walsh KM. A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros. Leukemia. 2016 05; 30(5):1194-7. PMID: 26437776.
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    18. Noseda M, Harada M, McSweeney S, Leja T, Belian E, Stuckey DJ, Abreu Paiva MS, Habib J, Macaulay I, de Smith A, al-Beidh F, Sampson R, Lumbers RT, Rao P, Harding SE, Blakemore AI, Jacobsen SE, Barahona M, Schneider MD. PDGFRa demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium. Nat Commun. 2015 May 18; 6:6930. PMID: 25980517; PMCID: PMC4479024.
    19. Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602. PMID: 25690899; PMCID: PMC4357708.
    20. Gonseth S, Roy R, Houseman EA, de Smith A, Zhou M, Lee ST, Nusslé S, Singer AW, Wrensch MR, Metayer C, Wiemels JL. Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes. Epigenetics. 2015; 10(12):1166-76. PMID: 26646725; PMCID: PMC4844202 [Available on 12/08/16].
    21. Walsh KM, de Smith A, Welch TC, Smirnov I, Cunningham MJ, Ma X, Chokkalingam AP, Dahl GV, Roberts W, Barcellos LF, Buffler PA, Metayer C, Wiemels JL. Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia. Am J Hematol. 2014 Jul; 89(7):721-5. PMID: 24753091; PMCID: PMC4069235.
    22. Xiao J, Lee ST, Xiao Y, Ma X, Houseman EA, Hsu LI, Roy R, Wrensch M, de Smith A, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer. 2014 Sep 01; 135(5):1101-9. PMID: 24496747; PMCID: PMC4776754.
    23. de Smith A, Walsh KM, Ladner MB, Zhang S, Xiao C, Cohen F, Moore TB, Chokkalingam AP, Metayer C, Buffler PA, Trachtenberg EA, Wiemels JL. The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood. 2014 Apr 17; 123(16):2497-503. PMID: 24518758; PMCID: PMC3990912.
    24. Martins-Taylor K, Hsiao JS, Chen PF, Glatt-Deeley H, De Smith AJ, Blakemore AI, Lalande M, Chamberlain SJ. Imprinted expression of UBE3A in non-neuronal cells from a Prader-Willi syndrome patient with an atypical deletion. Hum Mol Genet. 2014 May 01; 23(9):2364-73. PMID: 24363065; PMCID: PMC3976333.
    25. Walsh KM, de Smith A, Chokkalingam AP, Metayer C, Roberts W, Barcellos LF, Wiemels JL, Buffler PA. GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL. Blood. 2013 Nov 07; 122(19):3385-7. PMID: 24203929; PMCID: PMC3821727.
    26. Walsh KM, de Smith A, Chokkalingam AP, Metayer C, Dahl GV, Hsu LI, Barcellos LF, Wiemels JL, Buffler PA. Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype. Blood. 2013 Jun 06; 121(23):4808-9. PMID: 23744494; PMCID: PMC3674678.
    27. Walsh KM, Chokkalingam AP, Hsu LI, Metayer C, de Smith A, Jacobs DI, Dahl GV, Loh ML, Smirnov IV, Bartley K, Ma X, Wiencke JK, Barcellos LF, Wiemels JL, Buffler PA. Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children. Leukemia. 2013 Dec; 27(12):2416-9. PMID: 23615557; PMCID: PMC3864612.
    28. Walters RG, Coin LJ, Ruokonen A, de Smith A, El-Sayed Moustafa JS, Jacquemont S, Elliott P, Esko T, Hartikainen AL, Laitinen J, Männik K, Martinet D, Meyre D, Nauck M, Schurmann C, Sladek R, Thorleifsson G, Thorsteinsdóttir U, Valsesia A, Waeber G, Zufferey F, Balkau B, Pattou F, Metspalu A, Völzke H, Vollenweider P, Stefansson K, Järvelin MR, Beckmann JS, Froguel P, Blakemore AI. Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. PLoS One. 2013; 8(3):e58048. PMID: 23554873; PMCID: PMC3595275.
    29. Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, Zheng S, Dou X, de Smith A, Chokkalingam A, Buffler P, Ma X, Wiemels JL. A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res. 2012 Dec; 40(22):11339-51. PMID: 23074194; PMCID: PMC3526268.
    30. El-Sayed Moustafa JS, Eleftherohorinou H, de Smith A, Andersson-Assarsson JC, Alves AC, Hadjigeorgiou E, Walters RG, Asher JE, Bottolo L, Buxton JL, Sladek R, Meyre D, Dina C, Visvikis-Siest S, Jacobson P, Sjöström L, Carlsson LM, Walley A, Falchi M, Froguel P, Blakemore AI, Coin LJ. Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity. Hum Mol Genet. 2012 Aug 15; 21(16):3727-38. PMID: 22595969; PMCID: PMC3406755.
    31. Li Y, Zheng H, Luo R, Wu H, Zhu H, Li R, Cao H, Wu B, Huang S, Shao H, Ma H, Zhang F, Feng S, Zhang W, Du H, Tian G, Li J, Zhang X, Li S, Bolund L, Kristiansen K, de Smith A, Blakemore AI, Coin LJ, Yang H, Wang J, Wang J. Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nat Biotechnol. 2011 Jul 24; 29(8):723-30. PMID: 21785424.
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    32. Trewick AL, Moustafa JS, de Smith A, Froguel P, Greve G, Njølstad PR, Coin LJ, Blakemore AI. Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry. Clin Chem. 2011 Aug; 57(8):1188-95. PMID: 21677093.
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    33. de Smith A, van Haelst MM, Ellis RJ, Holder SE, Payne SJ, Hashim SK, Froguel P, Blakemore AI. Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. Am J Med Genet A. 2011 May; 155A(5):1192-5. PMID: 21465662.
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    34. Fernando MM, de Smith A, Coin L, Morris DL, Froguel P, Mangion J, Blakemore AI, Graham RR, Behrens TW, Vyse TJ. Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants. Ann Hum Genet. 2011 May; 75(3):383-97. PMID: 21401563.
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    35. de Smith A, Trewick AL, Blakemore AI. Implications of copy number variation in people with chromosomal abnormalities: potential for greater variation in copy number state may contribute to variability of phenotype. Hugo J. 2010 Dec; 4(1-4):1-9. PMID: 22132061; PMCID: PMC3051043.
    36. Coin LJ, Asher JE, Walters RG, Moustafa JS, de Smith A, Sladek R, Balding DJ, Froguel P, Blakemore AI. cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs. Nat Methods. 2010 Jul; 7(7):541-6. PMID: 20512141.
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    37. Walters RG, Jacquemont S, Valsesia A, de Smith A, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, Delobel B, Stutzmann F, El-Sayed Moustafa JS, Chèvre JC, Lecoeur C, Vatin V, Bouquillon S, Buxton JL, Boute O, Holder-Espinasse M, Cuisset JM, Lemaitre MP, Ambresin AE, Brioschi A, Gaillard M, Giusti V, Fellmann F, Ferrarini A, Hadjikhani N, Campion D, Guilmatre A, Goldenberg A, Calmels N, Mandel JL, Le Caignec C, David A, Isidor B, Cordier MP, Dupuis-Girod S, Labalme A, Sanlaville D, Béri-Dexheimer M, Jonveaux P, Leheup B, Ounap K, Bochukova EG, Henning E, Keogh J, Ellis RJ, Macdermot KD, van Haelst MM, Vincent-Delorme C, Plessis G, Touraine R, Philippe A, Malan V, Mathieu-Dramard M, Chiesa J, Blaumeiser B, Kooy RF, Caiazzo R, Pigeyre M, Balkau B, Sladek R, Bergmann S, Mooser V, Waterworth D, Reymond A, Vollenweider P, Waeber G, Kurg A, Palta P, Esko T, Metspalu A, Nelis M, Elliott P, Hartikainen AL, McCarthy MI, Peltonen L, Carlsson L, Jacobson P, Sjöström L, Huang N, Hurles ME, O'Rahilly S, Farooqi IS, Männik K, Jarvelin MR, Pattou F, Meyre D, Walley AJ, Coin LJ, Blakemore AI, Froguel P, Beckmann JS. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature. 2010 Feb 04; 463(7281):671-5. PMID: 20130649.
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    38. de Smith A, Purmann C, Walters RG, Ellis RJ, Holder SE, Van Haelst MM, Brady AF, Fairbrother UL, Dattani M, Keogh JM, Henning E, Yeo GS, O'Rahilly S, Froguel P, Farooqi IS, Blakemore AI. A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Hum Mol Genet. 2009 Sep 01; 18(17):3257-65. PMID: 19498035.
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    39. de Smith A, Walters RG, Froguel P, Blakemore AI. Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease. Cytogenet Genome Res. 2008; 123(1-4):17-26. PMID: 19287135; PMCID: PMC2920180.
    40. de Smith A, Walters RG, Coin LJ, Steinfeld I, Yakhini Z, Sladek R, Froguel P, Blakemore AI. Small deletion variants have stable breakpoints commonly associated with alu elements. PLoS One. 2008 Aug 29; 3(8):e3104. PMID: 18769679; PMCID: PMC2518860.
    41. de Smith A, Tsalenko A, Sampas N, Scheffer A, Yamada NA, Tsang P, Ben-Dor A, Yakhini Z, Ellis RJ, Bruhn L, Laderman S, Froguel P, Blakemore AI. Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Hum Mol Genet. 2007 Dec 01; 16(23):2783-94. PMID: 17666407.
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    42. Fanciulli M, Norsworthy PJ, Petretto E, Dong R, Harper L, Kamesh L, Heward JM, Gough SC, de Smith A, Blakemore AI, Froguel P, Owen CJ, Pearce SH, Teixeira L, Guillevin L, Graham DS, Pusey CD, Cook HT, Vyse TJ, Aitman TJ. FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet. 2007 Jun; 39(6):721-3. PMID: 17529978.
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