William Gauderman, PhD

Title(s)Professor of Population and Public Health Sciences
AddressSSB 202K 2001 N. Soto Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1567
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    Collapse Overview
    Dr. Gauderman's research falls into two distinct areas:

    1) developing statistical methods for genetic-epidemiologic analysis of pedigree data; 2) design and analysis of studies relating health outcomes to environmental exposures. In the field of genetic-epidemiology, he has developed models and methods of estimation for complex traits that depend on both genetic and environment causes, possibly interacting. He has evaluated a technique known as joint segregation and linkage analysis and has found it to be an efficient strategy both for detecting linkage and for estimating gene-environment interactions when the disease gene has not yet been identified. He has also compared various case-control designs for studying measured genes (e.g. candidate genes). In the field of environmental health, he works with the Children's Health Study, a multi-community study of lung function and respiratory health in school-aged children in the Southern California area. The ultimate goal of this research is to determine whether air pollution, or particular components of air pollution such as ozone, is associated with reduced lung growth and increased incidence of asthma, bronchitis, and other respiratory illnesses. He is also the principal investigator of the biostatistics core of the NIEHS Center, and thus is available for statistical consultation for projects involving environmental health.

    Collapse Research 
    Collapse Research Activities and Funding
    Using functional genomics to inform gene environment interactions for colorectal cancer
    NIH R01CA201407Sep 23, 2016 - Aug 31, 2021
    Role: Co-Principal Investigator
    Statistical Methods for Integrative Genomics in Cancer
    NIH P01CA196569Jul 1, 2016 - Jun 30, 2022
    Role: Co-Principal Investigator
    Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse Children
    NIH R21ES024844Dec 1, 2014 - Nov 30, 2017
    Role: Co-Principal Investigator
    Air pollution effects on asthma and lung function in Hispanic children
    NIH R03ES022719Jun 20, 2013 - May 31, 2016
    Role: Principal Investigator
    Detecting GxE Interactions in Genome-wide Association Studies
    NIH R21HL115606Mar 1, 2012 - Feb 29, 2016
    Role: Principal Investigator
    Software to compute sample size for high-volume genetic studies
    NIH R41CA141852Aug 1, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Remote Sensing of Wildfire Smoke Exposures to Assess Health Effects
    NIH R21ES016986Sep 5, 2008 - Aug 31, 2011
    Role: Co-Principal Investigator
    A Genome-wide Association Study of Childhood Respiratory Outcomes
    NIH R01HL087680May 20, 2007 - Apr 30, 2011
    Role: Principal Investigator
    Environmental Genomics
    NIH T32ES013678Apr 30, 2005 - Jun 30, 2024
    Role: Principal Investigator
    STATISTICAL APPROACHES TO THE STUDY OF GXE INTERACTIONS
    NIH R01ES010421May 1, 2000 - Apr 30, 2005
    Role: Principal Investigator
    TRAINING MODULES FOR CLINICAL EPIDEMIOLOGICAL RESEARCH
    NIH R43CA058240Sep 30, 1992 - May 31, 1993
    Role: Principal Investigator
    PEDIGREE ANALYSIS USING GIBBS SAMPLING
    NIH R43GM048326Sep 1, 1992 - Mar 31, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa089. Muskens IS, Feng Q, Francis SS, Walsh KM, Mckean-Cowdin R, Gauderman WJ, de Smith AJ, Wiemels JL. PMID: 32864610.
      View in: PubMed   Mentions:
    2. A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Hum Mol Genet. 2019 10 01; 28(19):3327-3338. Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo YY, Standl M, Leinonen JT, Holm JC, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi V, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SA, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson J, Widén E, McCarthy MI, Njølstad PR, Power C, Hyppönen E, Sebert S, Brown CD, Järvelin MR, Timpson NJ, Johansson S, Hakonarson H, Jaddoe VWV, Early Growth Genetics Consortium , Grant SFA. PMID: 31504550.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    3. Using Bayes model averaging to leverage both gene main effects and G?×? E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol. 2019 03; 43(2):150-165. Moss LC, Gauderman WJ, Lewinger JP, Conti DV. PMID: 30456811.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort. Cancer Genet. 2016 Apr; 209(4):130-7. Ricker C, Culver JO, Lowstuter K, Sturgeon D, Sturgeon JD, Chanock CR, Gauderman WJ, McDonnell KJ, Idos GE, Gruber SB. PMID: 26908360.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    5. Adaptive Set-Based Methods for Association Testing. Genet Epidemiol. 2016 Feb; 40(2):113-22. Su YC, Gauderman WJ, Berhane K, Lewinger JP. PMID: 26707371.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Finding novel genes by testing G × E interactions in a genome-wide association study. Genet Epidemiol. 2013 Sep; 37(6):603-13. Gauderman WJ, Zhang P, Morrison JL, Lewinger JP. PMID: 23873611.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    7. Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels. Front Genet. 2012; 3:117. Gao X, Haritunians T, Marjoram P, McKean-Cowdin R, Torres M, Taylor KD, Rotter JI, Gauderman WJ, Varma R. PMID: 22754564.
      View in: PubMed   Mentions:
    8. Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. Genet Epidemiol. 2011 Dec; 35(8):790-9. Li D, Lewinger JP, Gauderman WJ, Murcray CE, Conti D. PMID: 21922541.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    9. Efficient genome-wide association testing of gene-environment interaction in case-parent trios. Am J Epidemiol. 2010 Jul 01; 172(1):116-22. Gauderman WJ, Thomas DC, Murcray CE, Conti D, Li D, Lewinger JP. PMID: 20543031.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    10. Testing association between disease and multiple SNPs in a candidate gene. Genet Epidemiol. 2007 Jul; 31(5):383-95. Gauderman WJ, Murcray C, Gilliland F, Conti DV. PMID: 17410554.
      View in: PubMed   Mentions: 131     Fields:    Translation:Humans
    11. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet. 2007 Feb 17; 369(9561):571-7. Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, Lurmann F, Avol E, Kunzli N, Jerrett M, Peters J. PMID: 17307103.
      View in: PubMed   Mentions: 178     Fields:    Translation:Humans
    12. Indoor time-microenvironment-activity patterns in seven regions of Europe. J Expo Sci Environ Epidemiol. 2007 Mar; 17(2):170-81. Schweizer C, Edwards RD, Bayer-Oglesby L, Gauderman WJ, Ilacqua V, Jantunen MJ, Lai HK, Nieuwenhuijsen M, Künzli N. PMID: 16721413.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansPHPublic Health
    13. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology. 2005 Nov; 16(6):737-43. Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J, McConnell R. PMID: 16222162.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansPHPublic Health
    14. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004 Sep 09; 351(11):1057-67. Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J. PMID: 15356303.
      View in: PubMed   Mentions: 279     Fields:    Translation:HumansPHPublic Health
    15. Candidate gene association analysis for a quantitative trait, using parent-offspring trios. Genet Epidemiol. 2003 Dec; 25(4):327-38. Gauderman WJ. PMID: 14639702.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    16. Longitudinal data analysis in pedigree studies. Genet Epidemiol. 2003; 25 Suppl 1:S18-28. Gauderman WJ, Macgregor S, Briollais L, Scurrah K, Tobin M, Park T, Wang D, Rao S, John S, Bull S. PMID: 14635165.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    17. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51. Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. PMID: 12153968.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med. 2002 Jul 01; 166(1):76-84. Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, Thomas D, Lurmann F, Margolis HG, Rappaport EB, Berhane K, Peters JM. PMID: 12091175.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansPHPublic Health
    19. Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol. 2002 Mar 01; 155(5):478-84. Gauderman WJ. PMID: 11867360.
      View in: PubMed   Mentions: 238     Fields:    Translation:Humans
    20. Gene-environment interaction and affected sib pair linkage analysis. Hum Hered. 2001; 52(1):34-46. Gauderman WJ, Siegmund KD. PMID: 11359066.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
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