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William Gauderman, PhD

TitleProfessor of Preventive Medicine
InstitutionUniversity of Southern California
DepartmentPreventive Medicine
AddressSSB 202K 2001 N. Soto Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1567
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    Collapse Overview 
    Collapse Overview
    Dr. Gauderman's research falls into two distinct areas:

    1) developing statistical methods for genetic-epidemiologic analysis of pedigree data; 2) design and analysis of studies relating health outcomes to environmental exposures. In the field of genetic-epidemiology, he has developed models and methods of estimation for complex traits that depend on both genetic and environment causes, possibly interacting. He has evaluated a technique known as joint segregation and linkage analysis and has found it to be an efficient strategy both for detecting linkage and for estimating gene-environment interactions when the disease gene has not yet been identified. He has also compared various case-control designs for studying measured genes (e.g. candidate genes). In the field of environmental health, he works with the Children's Health Study, a multi-community study of lung function and respiratory health in school-aged children in the Southern California area. The ultimate goal of this research is to determine whether air pollution, or particular components of air pollution such as ozone, is associated with reduced lung growth and increased incidence of asthma, bronchitis, and other respiratory illnesses. He is also the principal investigator of the biostatistics core of the NIEHS Center, and thus is available for statistical consultation for projects involving environmental health.


    Collapse Research 
    Collapse Research Activities and Funding
    Using functional genomics to inform gene environment interactions for colorectal cancer
    NIH/NCI R01CA201407Sep 23, 2016 - Aug 31, 2021
    Role: Co-Principal Investigator
    Statistical Methods for Integrative Genomics in Cancer
    NIH/NCI P01CA196569Jul 1, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse Children
    NIH/NIEHS R21ES024844Dec 1, 2014 - Nov 30, 2017
    Role: Co-Principal Investigator
    Air pollution effects on asthma and lung function in Hispanic children
    NIH/NIEHS R03ES022719Jun 20, 2013 - May 31, 2015
    Role: Principal Investigator
    Detecting GxE Interactions in Genome-wide Association Studies
    NIH/NHLBI R21HL115606Mar 1, 2012 - Feb 28, 2015
    Role: Principal Investigator
    Software to compute sample size for high-volume genetic studies
    NIH/NCI R41CA141852Aug 1, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Remote Sensing of Wildfire Smoke Exposures to Assess Health Effects
    NIH/NIEHS R21ES016986Sep 5, 2008 - Aug 31, 2011
    Role: Co-Principal Investigator
    A Genome-wide Association Study of Childhood Respiratory Outcomes
    NIH/NHLBI R01HL087680May 20, 2007 - Apr 30, 2011
    Role: Principal Investigator
    Environmental Genomics
    NIH/NIEHS T32ES013678Apr 30, 2005 - Jun 30, 2018
    Role: Principal Investigator
    STATISTICAL APPROACHES TO THE STUDY OF GXE INTERACTIONS
    NIH/NIEHS R01ES010421May 1, 2000 - Apr 30, 2005
    Role: Principal Investigator
    TRAINING MODULES FOR CLINICAL EPIDEMIOLOGICAL RESEARCH
    NIH/NCI R43CA058240Sep 30, 1992 - May 31, 1993
    Role: Principal Investigator
    PEDIGREE ANALYSIS USING GIBBS SAMPLING
    NIH/NIGMS R43GM048326Sep 1, 1992 - Mar 31, 1993
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Moss LC, Gauderman WJ, Lewinger JP, Conti DV. Using Bayes model averaging to leverage both gene main effects and G?×? E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol. 2018 Nov 19. PMID: 30456811.
      View in: PubMed
    2. Ricker C, Culver JO, Lowstuter K, Sturgeon D, Sturgeon JD, Chanock CR, Gauderman WJ, McDonnell KJ, Idos GE, Gruber SB. Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort. Cancer Genet. 2016 Apr; 209(4):130-7. PMID: 26908360; PMCID: PMC4835267 [Available on 04/01/17].
    3. Su YC, Gauderman WJ, Berhane K, Lewinger JP. Adaptive Set-Based Methods for Association Testing. Genet Epidemiol. 2016 Feb; 40(2):113-22. PMID: 26707371.
      View in: PubMed
    4. Gauderman WJ, Zhang P, Morrison JL, Lewinger JP. Finding novel genes by testing G × E interactions in a genome-wide association study. Genet Epidemiol. 2013 Sep; 37(6):603-13. PMID: 23873611; PMCID: PMC4348012.
    5. Gao X, Haritunians T, Marjoram P, McKean-Cowdin R, Torres M, Taylor KD, Rotter JI, Gauderman WJ, Varma R. Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels. Front Genet. 2012; 3:117. PMID: 22754564; PMCID: PMC3384355.
    6. Li D, Lewinger JP, Gauderman WJ, Murcray CE, Conti D. Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. Genet Epidemiol. 2011 Dec; 35(8):790-9. PMID: 21922541; PMCID: PMC4238184.
    7. Gauderman WJ, Thomas DC, Murcray CE, Conti D, Li D, Lewinger JP. Efficient genome-wide association testing of gene-environment interaction in case-parent trios. Am J Epidemiol. 2010 Jul 01; 172(1):116-22. PMID: 20543031; PMCID: PMC2915477.
    8. Gauderman WJ, Murcray C, Gilliland F, Conti DV. Testing association between disease and multiple SNPs in a candidate gene. Genet Epidemiol. 2007 Jul; 31(5):383-95. PMID: 17410554.
      View in: PubMed
    9. Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, Lurmann F, Avol E, Kunzli N, Jerrett M, Peters J. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet. 2007 Feb 17; 369(9561):571-7. PMID: 17307103.
      View in: PubMed
    10. Schweizer C, Edwards RD, Bayer-Oglesby L, Gauderman WJ, Ilacqua V, Jantunen MJ, Lai HK, Nieuwenhuijsen M, Künzli N. Indoor time-microenvironment-activity patterns in seven regions of Europe. J Expo Sci Environ Epidemiol. 2007 Mar; 17(2):170-81. PMID: 16721413.
      View in: PubMed
    11. Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J, McConnell R. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology. 2005 Nov; 16(6):737-43. PMID: 16222162.
      View in: PubMed
    12. Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004 Sep 09; 351(11):1057-67. PMID: 15356303.
      View in: PubMed
    13. Gauderman WJ. Candidate gene association analysis for a quantitative trait, using parent-offspring trios. Genet Epidemiol. 2003 Dec; 25(4):327-38. PMID: 14639702.
      View in: PubMed
    14. Gauderman WJ, Macgregor S, Briollais L, Scurrah K, Tobin M, Park T, Wang D, Rao S, John S, Bull S. Longitudinal data analysis in pedigree studies. Genet Epidemiol. 2003; 25 Suppl 1:S18-28. PMID: 14635165.
      View in: PubMed
    15. Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51. PMID: 12153968.
      View in: PubMed
    16. Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, Thomas D, Lurmann F, Margolis HG, Rappaport EB, Berhane K, Peters JM. Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med. 2002 Jul 01; 166(1):76-84. PMID: 12091175.
      View in: PubMed
    17. Gauderman WJ. Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol. 2002 Mar 01; 155(5):478-84. PMID: 11867360.
      View in: PubMed
    18. Gauderman WJ, Siegmund KD. Gene-environment interaction and affected sib pair linkage analysis. Hum Hered. 2001; 52(1):34-46. PMID: 11359066.
      View in: PubMed