Xuejuan Jiang, PhD

Title(s)Assistant Professor of Research Ophthalmology
SchoolKeck School of Medicine of USC
Phone+1 323 865 6929
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    Collapse Biography 
    Collapse Education and Training
    University of Science and Technology of ChinaBS2002
    University of Southern CaliforniaMS2004
    University of Southern CaliforniaPhD2007
    Collapse Awards and Honors
    University of Science and Technology of China2002Honor Graduate
    University of Southern California2005International Student Academic Achievement Award

    Collapse Overview 
    Collapse Overview
    Xuejuan Jiang received a BS with Honors in Molecular and Cellular Biology from University of Science and Technology of China in 2002. Subsequently, she joined the graduate program in Biomedical and Biological Sciences (PIBBS) at University of Southern California (USC), and received a M.S. in Applied Biostatistics and Epidemiology and a PhD in Epidemiology. At USC, Dr. Jiang investigated how smoking affects bladder cancer risk. Her research provided strong evidence supporting that 1) second-hand smoke can increase bladder cancer risk in female lifelong nonsmokers, 2) genetic variations associated with nicotine dependence and smoking behavior can also affect bladder cancer risk, and 3) use of non-steroidal anti-inflammatory may attenuate the carcinogenic effect of cigarette smoking on the bladder. In addition, she found that factors associated with prolonged exposure to carcinogens in the urine, e.g. infrequent drinking and urination, may increase bladder cancer risk. After earning her doctorate, Dr. Jiang became a postdoctoral research associate at USC, where she focused on using pathway-based systemic approaches to investigate genetic components of adolescent alcohol drinking, bladder cancer, and colorectal cancer, and developing noninvasive biomarkers of oxidative stress. Dr. Jiang joined USC’s Department of Ophthalmology as an Assistant Professor of Research in 2011.

    As an experienced epidemiologist, Xuejuan Jiang, PhD, has expertise in designing, managing and analyzing epidemiological studies to evaluate the impact of different environmental and genetic risk factors, on various cancers, adolescent smoking/drinking behaviors, and ocular disorders. In particular, Dr. Jiang’s research on ocular disease focuses on etiologies of glaucoma, diabetic retinopathy, and refractive errors, especially myopia, identifying early indicators of disease development and progression, and developing possible prevention, intervention and treatments.

    Dr. Jiang is currently leading the international effort in consolidating all existing population-based studies of eye diseases among preschool children, to create the largest repository of population-based survey data on vision health among preschool children. Results from this project will improve our understanding of the risk factors for the most common pediatric vision disorders among preschool children, and help inform and develop evidence-based guidelines for population screening and clinical management.

    Collapse Research 
    Collapse Research Activities and Funding
    Cumulative Effects of Sickle Cell Trait on the Eye among Older African Americans
    NIH/NEI R21EY028721Mar 1, 2018 - Feb 29, 2020
    Role: Principal Investigator
    The Pediatric Eye Disease Consortium: a Pooled Analysis of Individual-Participant Data from Population-based Studies
    NIH/NEI R21EY025313Jun 1, 2015 - May 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Jiang X, Tarczy-Hornoch K, Stram D, Katz J, Friedman DS, Tielsch JM, Matsumura S, Saw SM, Mitchell P, Rose KA, Cotter SA, Varma R. Prevalence, Characteristics, and Risk Factors of Moderate/High Hyperopia among Multiethnic Children 6 to 72 Months Old - A Pooled Analysis of Individual Participant Data. Ophthalmology. 2019 Feb 26. PMID: 30822446.
      View in: PubMed
    2. Varma R, Jiang X. The "Curse" of the Fellow Eye in Glaucoma. JAMA Ophthalmol. 2018 Oct 01; 136(10):1156-1157. PMID: 30098139.
      View in: PubMed
    3. McKean-Cowdin R, Fairbrother-Crisp A, Torres M, Lastra C, Choudhury F, Jiang X, Burkemper B, Varma R. The African American Eye Disease Study: Design and Methods. Ophthalmic Epidemiol. 2018 Aug; 25(4):306-314. PMID: 29580111.
      View in: PubMed
    4. Jiang X, Torres M, Varma R. Variation in Intraocular Pressure and the Risk of Developing Open-Angle Glaucoma: The Los Angeles Latino Eye Study. Am J Ophthalmol. 2018 04; 188:51-59. PMID: 29360458.
      View in: PubMed
    5. Choudhury F, Meuer SM, Klein R, Wang D, Torres M, Jiang X, McKean-Cowdin R, Varma R. Prevalence and Characteristics of Myopic Degeneration in an Adult Chinese American Population: The Chinese American Eye Study. Am J Ophthalmol. 2018 03; 187:34-42. PMID: 29288031.
      View in: PubMed
    6. Stram DA, Jiang X, Varma R, Torres M, Burkemper BS, Choudhury F, Klein R, Gauderman WJ, McKean-Cowdin R. Factors Associated with Prevalent Diabetic Retinopathy in Chinese Americans: The Chinese American Eye Study. Ophthalmol Retina. 2018 Feb; 2(2):96-105. PMID: 29503969.
      View in: PubMed
    7. Richter GM, Wang M, Jiang X, Wu S, Wang D, Torres M, Choudhury F, Varma R. Ocular Determinants of Refractive Error and Its Age- and Sex-Related Variations in the Chinese American Eye Study. JAMA Ophthalmol. 2017 Jul 01; 135(7):724-732. PMID: 28520882.
      View in: PubMed
    8. Varma R, Jiang X. Use of Structural End Points in Glaucoma: Beyond Visual Field Loss. JAMA Ophthalmol. 2017 Jul 01; 135(7):789-790. PMID: 28594985.
      View in: PubMed
    9. Varma R, Tarczy-Hornoch K, Jiang X. Visual Impairment in Preschool Children in the United States: Demographic and Geographic Variations From 2015 to 2060. JAMA Ophthalmol. 2017 06 01; 135(6):610-616. PMID: 28472231.
      View in: PubMed
    10. Jiang X, Varma R, Torres M, Hsu C, McKean-Cowdin R. Self-reported Use of Eye Care Among Adult Chinese Americans: The Chinese American Eye Study. Am J Ophthalmol. 2017 Apr; 176:183-193. PMID: 28161048.
      View in: PubMed
    11. Xu BY, Israelsen P, Pan BX, Wang D, Jiang X, Varma R. Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study. Invest Ophthalmol Vis Sci. 2016 11 01; 57(14):6313-6319. PMID: 27893097.
      View in: PubMed
    12. Varma R, Torres M, McKean-Cowdin R, Rong F, Hsu C, Jiang X. Prevalence and Risk Factors for Refractive Error in Adult Chinese Americans: The Chinese American Eye Study. Am J Ophthalmol. 2017 Mar; 175:201-212. PMID: 27769895.
      View in: PubMed
    13. Varma R, Jiang X. The Role of Contextual Factors in Racial/Ethnic Disparities in Eye Care Use. JAMA Ophthalmol. 2016 10 01; 134(10):1167-1168. PMID: 27560770.
      View in: PubMed
    14. Kim AY, Rodger DC, Shahidzadeh A, Chu Z, Koulisis N, Burkemper B, Jiang X, Pepple KL, Wang RK, Puliafito CA, Rao NA, Kashani AH. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016 Nov; 171:101-112. PMID: 27594138.
      View in: PubMed
    15. Varma R, Wen G, Jiang X, Hsu C, Torres M, Klein R, Azen SP, McKean-Cowdin R. Prevalence of Diabetic Retinopathy in Adult Chinese American Individuals: The Chinese American Eye Study. JAMA Ophthalmol. 2016 Apr 07. PMID: 27055063.
      View in: PubMed
    16. Jiang X, Castelao JE, Vandenberg D, Carracedo A, Redondo CM, Conti DV, Paredes Cotoré JP, Potter JD, Newcomb PA, Passarelli MN, Jenkins MA, Hopper JL, Gallinger S, Le Marchand L, Martínez ME, Ahnen DJ, Baron JA, Lindor NM, Haile RW, Gago-Dominguez M. Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry. PLoS One. 2013; 8(4):e60464. PMID: 23560096; PMCID: PMC3616155.
    17. Mitra AP, Castelao JE, Hawes D, Tsao-Wei DD, Jiang X, Shi SR, Datar RH, Skinner EC, Stein JP, Groshen S, Yu MC, Ross RK, Skinner DG, Cortessis VK, Cote RJ. Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program. Cancer. 2013 Feb 15; 119(4):756-65. PMID: 23319010; PMCID: PMC3565093.
    18. Jiang X, Varma R, Wu S, Torres M, Azen SP, Francis BA, Chopra V, Nguyen BB. Baseline risk factors that predict the development of open-angle glaucoma in a population: the Los Angeles Latino Eye Study. Ophthalmology. 2012 Nov; 119(11):2245-53. PMID: 22796305; PMCID: PMC3474872.
    19. Jiang X, Bernstein L, Tseng CC, Wu AH. Diabetes and risk of esophageal and gastric adenocarcinomas. Int J Cancer. 2012 Sep 15; 131(6):1417-22. PMID: 22161620; PMCID: PMC3340473.
    20. Jiang X, Castelao JE, Chavez-Uribe E, Fernandez Rodriguez B, Celeiro Muñoz C, Redondo CM, Peña Fernandez M, Novo Dominguez A, Pereira CD, Martínez ME, García-Caballero T, Fraga Rodriguez M, Antúnez J, Carracedo A, Forteza-Vila J, Gago-Dominguez M. Family history and breast cancer hormone receptor status in a Spanish cohort. PLoS One. 2012; 7(1):e29459. PMID: 22238615; PMCID: PMC3253097.
    21. Jiang X, Castelao JE, Yuan JM, Stern MC, Conti DV, Cortessis VK, Pike MC, Gago-Dominguez M. Cigarette smoking and subtypes of bladder cancer. Int J Cancer. 2012 Feb 15; 130(4):896-901. PMID: 21412765; PMCID: PMC3210924.
    22. Li D, London SJ, Liu J, Lee W, Jiang X, Van Den Berg D, Bergen AW, Nishita D, Waleh N, Swan GE, Gallaher P, Chou CP, Shih JC, Unger JB, Gauderman WJ, Gilliland F, Johnson CA, Conti DV. Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. Am J Epidemiol. 2011 May 01; 173(9):1039-48. PMID: 21415033; PMCID: PMC3121219.
    23. Gago-Dominguez M, Jiang X, Conti DV, Castelao JE, Stern MC, Cortessis VK, Pike MC, Xiang YB, Gao YT, Yuan JM, Van Den Berg DJ. Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis. 2011 Feb; 32(2):197-202. PMID: 21081471; PMCID: PMC3026841.
    24. Cortessis VK, Yuan JM, Van Den Berg D, Jiang X, Gago-Dominguez M, Stern MC, Castelao JE, Xiang YB, Gao YT, Pike MC, Conti DV. Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study. Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3150-6. PMID: 21051319; PMCID: PMC3417222.
    25. Jiang X, Castelao JE, Yuan JM, Groshen S, Stern MC, Conti DV, Cortessis VK, Coetzee GA, Pike MC, Gago-Dominguez M. Hypertension, diuretics and antihypertensives in relation to bladder cancer. Carcinogenesis. 2010 Nov; 31(11):1964-71. PMID: 20732908; PMCID: PMC2966553.
    26. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata D, Conti DV, Yuan JM, Pike MC, Gago-Dominguez M. Urinary tract infections and reduced risk of bladder cancer in Los Angeles. Br J Cancer. 2009 Mar 10; 100(5):834-9. PMID: 19174821; PMCID: PMC2653778.
    27. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata DK, Conti DV, Gago-Dominguez M. Water intake and bladder cancer risk in Los Angeles County. Int J Cancer. 2008 Oct 01; 123(7):1649-56. PMID: 18623082.
      View in: PubMed
    28. Jiang X, Castelao JE, Groshen S, Cortessis VK, Ross RK, Conti DV, Gago-Dominguez M. Alcohol consumption and risk of bladder cancer in Los Angeles County. Int J Cancer. 2007 Aug 15; 121(4):839-45. PMID: 17440923.
      View in: PubMed
    29. Jiang X, Yuan JM, Skipper PL, Tannenbaum SR, Yu MC. Environmental tobacco smoke and bladder cancer risk in never smokers of Los Angeles County. Cancer Res. 2007 Aug 01; 67(15):7540-5. PMID: 17671226.
      View in: PubMed
    30. Gago-Dominguez M, Jiang X, Castelao JE. Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis. Breast Cancer Res. 2007; 9(1):201. PMID: 17224037; PMCID: PMC1851400.
    31. Gago-Dominguez M, Jiang X, Esteban Castelao J. Lipid peroxidation and the protective effect of physical exercise on breast cancer. Med Hypotheses. 2007; 68(5):1138-43. PMID: 17113718.
      View in: PubMed