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Darryl Shibata, MD

Title(s)Professor of Pathology
Phone+1 323 865 3298
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    After attending UCLA for his undergraduate degree, Dr. Shibata obtained his medical degree from the Keck School of Medicine of USC. After completing his internship training in pediatrics from UC San Diego, Dr. Shibata returned to USC for his residency and fellowship at LAC+USC Medical Center. Currently, Dr. Shibata has clinical appointments at both LAC+USC Medical Center and USC/Norris Comprehensive Cancer Center. In addition to his wide array of responsibilities in the research, education and practitioner capacities, Dr. Shibata sits on the editorial board of the BMC Cancer Journal and the American Journal of Pathology.

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    Arizona Cancer and Evolution Center (ACE)
    NIH/NCI U54CA217376Apr 12, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    "Born to be Bad": Is Abnormal Cell Mobility Already Present At Initiation?
    NIH/NCI R21CA185016Jul 30, 2014 - May 31, 2016
    Role: Principal Investigator
    How Do NSAIDs Prevent Colorectal Cancer
    NIH/NCI R21CA170814Sep 13, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Tumor Diversity As A Biomarker For Colorectal Cancer
    NIH/NCI R21CA149990Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    How Do Colorectal Cancers Arise Despite Surveillance?
    NIH/NCI R33CA111940Aug 1, 2005 - Jun 30, 2010
    Role: Principal Investigator
    HUMAN COLON STEM CELL AND CRYPT DYNAMICS
    NIH/NIDDK R21DK061140Sep 30, 2001 - Aug 31, 2005
    Role: Principal Investigator
    Fixing Fixed DNA
    NIH/NCI R21CA091301Jul 1, 2001 - Jun 30, 2004
    Role: Principal Investigator
    Mouse Models of Early Intestinal Neoplasia
    NIH/NCI R01CA080077Jan 1, 1999 - Mar 31, 2010
    Role: Principal Investigator
    PATHOLOGY OF TUMOR GROWTH
    NIH/NCI R01CA070858May 21, 1997 - Apr 30, 2001
    Role: Principal Investigator
    PATHOLOGY OF TUMOR GROWTH
    NIH/NCI R55CA070858Sep 15, 1996 - Apr 30, 1997
    Role: Principal Investigator
    PATHOLOGY OF GASTRIC CANCER
    NIH/NCI R01CA058704Feb 1, 1993 - Jan 31, 1999
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Maley CC, Shibata D. Cancer cell evolution through the ages. Science. 2019 08 02; 365(6452):440-441. PMID: 31371596.
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    2. Chen B, Shi Z, Chen Q, Shen X, Shibata D, Wen H, Wu CI. Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution. Mol Biol Evol. 2019 Jul 01; 36(7):1430-1441. PMID: 30912799.
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    3. Shibata D. Somatic cell evolution: how to improve with age. J Pathol. 2019 01; 247(1):3-5. PMID: 30246391.
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    4. Ryser MD, Yu M, Grady W, Siegmund K, Shibata D. Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. Sci Rep. 2018 Nov 23; 8(1):17292. PMID: 30470817.
      View in: PubMed
    5. Shibata D. Evolutionary Stem Cell Poker and Cancer Risks: The Paradox of The Large And Small Intestines. Curr Pathobiol Rep. 2018 Sep; 6(3):193-198. PMID: 30713810.
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    6. Ryser MD, Min BH, Siegmund KD, Shibata D. Spatial mutation patterns as markers of early colorectal tumor cell mobility. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5774-5779. PMID: 29760052.
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    7. Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu CI, Schiffman JD, Hwang ES, Polyak K, Anderson ARA, Brown JS, Greaves M, Shibata D. Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 10; 17(10):605-619. PMID: 28912577.
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    8. Sun R, Hu Z, Sottoriva A, Graham TA, Harpak A, Ma Z, Fischer JM, Shibata D, Curtis C. Between-region genetic divergence reflects the mode and tempo of tumor evolution. Nat Genet. 2017 Jul; 49(7):1015-1024. PMID: 28581503.
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    9. Zhao J, Salomon MP, Shibata D, Curtis C, Siegmund K, Marjoram P. Early mutation bursts in colorectal tumors. PLoS One. 2017; 12(3):e0172516. PMID: 28257429.
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    10. Fischer JM, Calabrese PP, Miller AJ, Muñoz NM, Grady WM, Shibata D, Liskay RM. Single cell lineage tracing reveals a role for TgfßR2 in intestinal stem cell dynamics and differentiation. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12192-12197. PMID: 27791005.
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    11. Siegmund K, Shibata D. At least two well-spaced samples are needed to genotype a solid tumor. BMC Cancer. 2016 Mar 25; 16:250. PMID: 27015839.
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    12. Raub CB, Lee CC, Shibata D, Taylor C, Kartalov E. HistoMosaic Detecting KRAS G12V Mutation Across Colorectal Cancer Tissue Slices through in Situ PCR. Anal Chem. 2016 Mar 01; 88(5):2792-8. PMID: 26820161.
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    13. Ramaswamy K, Yik WY, Wang XM, Oliphant EN, Lu W, Shibata D, Ryder OA, Hacia JG. Derivation of induced pluripotent stem cells from orangutan skin fibroblasts. BMC Res Notes. 2015 Oct 16; 8:577. PMID: 26475477; PMCID: PMC4609060.
    14. Wang XM, Yik WY, Zhang P, Lu W, Huang N, Kim BR, Shibata D, Zitting M, Chow RH, Moser AB, Steinberg SJ, Hacia JG. Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities. Stem Cell Res Ther. 2015 Aug 29; 6:158. PMID: 26319495.
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    15. Kang H, Salomon MP, Sottoriva A, Zhao J, Toy M, Press MF, Curtis C, Marjoram P, Siegmund K, Shibata D. Many private mutations originate from the first few divisions of a human colorectal adenoma. J Pathol. 2015 Nov; 237(3):355-62. PMID: 26119426.
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    16. Walther V, Hiley CT, Shibata D, Swanton C, Turner PE, Maley CC. Can oncology recapitulate paleontology? Lessons from species extinctions. Nat Rev Clin Oncol. 2015 May; 12(5):273-85. PMID: 25687908.
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    17. Sottoriva A, Kang H, Ma Z, Graham TA, Salomon MP, Zhao J, Marjoram P, Siegmund K, Press MF, Shibata D, Curtis C. A Big Bang model of human colorectal tumor growth. Nat Genet. 2015 Mar; 47(3):209-16. PMID: 25665006.
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    18. Siddiqi IN, Shibata D. Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):78-80. PMID: 25153495.
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    19. Zhao J, Siegmund KD, Shibata D, Marjoram P. Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45. PMID: 24907673.
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    20. Siddiqi IN, Ailawadhi S, Huang Q, Shibata RK, Kang H, Shibata D. Deep sequencing reveals lack of a clonal relationship between a metachronous classical hodgkin and diffuse large B-cell lymphoma. Clin Lymphoma Myeloma Leuk. 2014 Jun; 14(3):e87-93. PMID: 24548610.
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    21. Kang H, Shibata D. Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection. Front Oncol. 2013 Oct 14; 3:264. PMID: 24133655.
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    22. Fischer JM, Schepers AG, Clevers H, Shibata D, Liskay RM. Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis. 2014 Jan; 35(1):237-46. PMID: 23996931.
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    23. Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, Brown AM, Ng K, Ma J, Wienholds E, Dunant C, Pollett A, Gallinger S, McPherson J, Mullighan CG, Shibata D, Dick JE. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science. 2013 Feb 01; 339(6119):543-8. PMID: 23239622.
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    24. Sottoriva A, Spiteri I, Shibata D, Curtis C, Tavaré S. Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. Cancer Res. 2013 Jan 01; 73(1):41-9. PMID: 23090114.
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    25. Wang XM, Yik WY, Zhang P, Lu W, Dranchak PK, Shibata D, Steinberg SJ, Hacia JG. The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis. Stem Cell Res Ther. 2012 Oct 04; 3(5):39. PMID: 23036268.
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    26. Shibata D. Cancer. Heterogeneity and tumor history. Science. 2012 Apr 20; 336(6079):304-5. PMID: 22517848.
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    27. Tsai AG, Chen DM, Lin M, Hsieh JC, Okitsu CY, Taghva A, Shibata D, Hsieh CL. Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells. DNA Cell Biol. 2012 Jun; 31(6):893-907. PMID: 22277069.
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    28. Wolkenhauer O, Shibata D, Mesarovic MD. The role of theorem proving in systems biology. J Theor Biol. 2012 May 07; 300:57-61. PMID: 22244914.
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    29. Wang X, Kang GH, Campan M, Weisenberger DJ, Long TI, Cozen W, Bernstein L, Wu AH, Siegmund KD, Shibata D, Laird PW. Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors. PLoS One. 2011; 6(10):e25985. PMID: 22028801.
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    30. Fischer JM, Miller AJ, Shibata D, Liskay RM. Different phenotypic consequences of simultaneous versus stepwise Apc loss. Oncogene. 2012 Apr 19; 31(16):2028-38. PMID: 21892206.
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    31. Shibata D. Molecular tumor clocks to study the evolution of drug resistance. Mol Pharm. 2011 Dec 05; 8(6):2050-4. PMID: 21732670.
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    32. Siegmund KD, Marjoram P, Tavaré S, Shibata D. High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. PLoS One. 2011; 6(6):e21657. PMID: 21738754.
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    33. Oghamian S, Sodir NM, Bashir MU, Shen H, Cullins AE, Carroll CA, Kundu P, Shibata D, Laird PW. Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis. 2011 Jun; 32(6):829-35. PMID: 21362628.
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    34. Wolkenhauer O, Shibata DK, Mesarovic MD. A stem cell niche dominance theorem. BMC Syst Biol. 2011 Jan 08; 5:4. PMID: 21214945.
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    35. Shibata D. Mutation and epigenetic molecular clocks in cancer. Carcinogenesis. 2011 Feb; 32(2):123-8. PMID: 21076057.
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    36. Wolkenhauer O, Shibata D, Mesarovic MD. A stem cell niche dominance theorem. J Stem Cells Regen Med. 2010; 6(2):98. PMID: 24693115.
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    37. Hong YJ, Marjoram P, Shibata D, Siegmund KD. Using DNA methylation patterns to infer tumor ancestry. PLoS One. 2010 Aug 09; 5(8):e12002. PMID: 20711251.
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    38. Shibata D, Lieber MR. Is there any genetic instability in human cancer? DNA Repair (Amst). 2010 Aug 05; 9(8):858; discussion 859-60. PMID: 20605538.
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    39. Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia JG. Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27. PMID: 20069569.
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    40. Wu AH, Siegmund KD, Long TI, Cozen W, Wan P, Tseng CC, Shibata D, Laird PW. Hormone therapy, DNA methylation and colon cancer. Carcinogenesis. 2010 Jun; 31(6):1060-7. PMID: 20064828.
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    41. Calabrese P, Shibata D. A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. BMC Cancer. 2010 Jan 05; 10:3. PMID: 20051132.
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    42. Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan 01; 70(1):12-3. PMID: 20028868.
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    43. Siegmund KD, Marjoram P, Tavaré S, Shibata D. Many colorectal cancers are "flat" clonal expansions. Cell Cycle. 2009 Jul 15; 8(14):2187-93. PMID: 19556889.
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    44. Siegmund KD, Marjoram P, Woo YJ, Tavaré S, Shibata D. Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4828-33. PMID: 19261858.
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    45. Woo YJ, Siegmund KD, Tavaré S, Shibata D. Older individuals appear to acquire mitotically older colorectal cancers. J Pathol. 2009 Mar; 217(4):483-8. PMID: 19165870.
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    46. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata D, Conti DV, Yuan JM, Pike MC, Gago-Dominguez M. Urinary tract infections and reduced risk of bladder cancer in Los Angeles. Br J Cancer. 2009 Mar 10; 100(5):834-9. PMID: 19174821.
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    47. Shibata D. Inferring human stem cell behaviour from epigenetic drift. J Pathol. 2009 Jan; 217(2):199-205. PMID: 19031430.
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    48. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata DK, Conti DV, Gago-Dominguez M. Water intake and bladder cancer risk in Los Angeles County. Int J Cancer. 2008 Oct 01; 123(7):1649-56. PMID: 18623082.
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    49. Siegmund KD, Marjoram P, Shibata D. Modeling DNA methylation in a population of cancer cells. Stat Appl Genet Mol Biol. 2008; 7(1):Article 18. PMID: 18597664.
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    50. Basile LA, Gallaher TK, Shibata D, Miller JD, Douer D. Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. J Transl Med. 2008 May 19; 6:26. PMID: 18489769.
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    51. Chu M, Siegmund KD, Hao QL, Crooks GM, Tavaré S, Shibata D. Inferring relative numbers of human leucocyte genome replications. Br J Haematol. 2008 Jun; 141(6):862-71. PMID: 18410448.
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    52. Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, Mecklin JP, Järvinen H, Eng C, Moeslein G, Shibata D, Houlston RS, Lucassen A, Tomlinson IP, Launonen V, Ristimäki A, Arango D, Karhu A, Sweeney HL, Aaltonen LA. Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5513-8. PMID: 18391202.
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    53. Miller AJ, Dudley SD, Tsao JL, Shibata D, Liskay RM. Tractable Cre-lox system for stochastic alteration of genes in mice. Nat Methods. 2008 Mar; 5(3):227-9. PMID: 18264106.
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    54. Shibata D. Mistakes make history: visualizing intestinal tectonics. Gastroenterology. 2008 Feb; 134(2):628-31. PMID: 18242228.
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    55. Shibata D. Stem cells as common ancestors in a colorectal cancer ancestral tree. Curr Opin Gastroenterol. 2008 Jan; 24(1):59-63. PMID: 18043234.
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    56. Shibata DK, Kern SE. Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis. Breast Dis. 2008; 29:15-25. PMID: 19029621.
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    57. Kern SE, Shibata D. The fuzzy math of solid tumor stem cells: a perspective. Cancer Res. 2007 Oct 01; 67(19):8985-8. PMID: 17908998.
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    58. Chu MW, Siegmund KD, Eckstam CL, Kim JY, Yang AS, Kanel GC, Tavaré S, Shibata D. Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet. 2007 Jul 31; 8:50. PMID: 17672908.
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    59. Chen T, Burke KA, Zhan Y, Wang X, Shibata D, Zhao Y. IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation. Exp Hematol. 2007 Feb; 35(2):203-13. PMID: 17258069.
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    60. Nicolas P, Kim KM, Shibata D, Tavaré S. The stem cell population of the human colon crypt: analysis via methylation patterns. PLoS Comput Biol. 2007 Mar 02; 3(3):e28. PMID: 17335343.
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    61. Shibata D, Tavaré S. Stem cell chronicles: autobiographies within genomes. Stem Cell Rev. 2007 Jan; 3(1):94-103. PMID: 17873386.
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    62. Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, Baratti D, Bartlett D, Barone R, Barrios P, Bieligk S, Bretcha-Boix P, Chang CK, Chu F, Chu Q, Daniel S, de Bree E, Deraco M, Dominguez-Parra L, Elias D, Flynn R, Foster J, Garofalo A, Gilly FN, Glehen O, Gomez-Portilla A, Gonzalez-Bayon L, Gonzalez-Moreno S, Goodman M, Gushchin V, Hanna N, Hartmann J, Harrison L, Hoefer R, Kane J, Kecmanovic D, Kelley S, Kuhn J, Lamont J, Lange J, Li B, Loggie B, Mahteme H, Mann G, Martin R, Misih RA, Moran B, Morris D, Onate-Ocana L, Petrelli N, Philippe G, Pingpank J, Pitroff A, Piso P, Quinones M, Riley L, Rutstein L, Saha S, Alrawi S, Sardi A, Schneebaum S, Shen P, Shibata D, Spellman J, Stojadinovic A, Stewart J, Torres-Melero J, Tuttle T, Verwaal V, Villar J, Wilkinson N, Younan R, Zeh H, Zoetmulder F, Sebbag G. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol. 2007 Jan; 14(1):128-33. PMID: 17072675.
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    63. Sodir NM, Chen X, Park R, Nickel AE, Conti PS, Moats R, Bading JR, Shibata D, Laird PW. Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res. 2006 Sep 01; 66(17):8430-8. PMID: 16951153.
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    64. Shibata D. Clonal diversity in tumor progression. Nat Genet. 2006 Apr; 38(4):402-3. PMID: 16570060.
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    65. Shibata D, Tavaré S. Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle. 2006 Mar; 5(6):610-4. PMID: 16582617.
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    66. Kim JY, Tavaré S, Shibata D. Human hair genealogies and stem cell latency. BMC Biol. 2006 Feb 03; 4:2. PMID: 16457718.
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    67. Shibata D. When does MMR loss occur during HNPCC progression? Cancer Biomark. 2006; 2(1-2):29-35. PMID: 17192057.
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    68. Kim JY, Tavaré S, Shibata D. Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17739-44. PMID: 16314580.
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    69. Calabrese P, Mecklin JP, Järvinen HJ, Aaltonen LA, Tavaré S, Shibata D. Numbers of mutations to different types of colorectal cancer. BMC Cancer. 2005 Oct 03; 5:126. PMID: 16202134.
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    70. Kabbarah O, Sotelo AK, Mallon MA, Winkeler EL, Fan MY, Pfeifer JD, Shibata D, Gutmann DH, Goodfellow PJ. Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice. Int J Cancer. 2005 Jul 01; 115(4):666-9. PMID: 15700306.
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    71. Kim JY, Siegmund KD, Tavaré S, Shibata D. Age-related human small intestine methylation: evidence for stem cell niches. BMC Med. 2005 Jun 23; 3:10. PMID: 15975143.
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    72. Kim JY, Beart RW, Shibata D. Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. BMC Gastroenterol. 2005 Jun 07; 5:19. PMID: 15941485.
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    73. Irvine RA, Adachi N, Shibata DK, Cassell GD, Yu K, Karanjawala ZE, Hsieh CL, Lieber MR. Generation and characterization of endonuclease G null mice. Mol Cell Biol. 2005 Jan; 25(1):294-302. PMID: 15601850.
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    74. Xie Y, Yang H, Cunanan C, Okamoto K, Shibata D, Pan J, Barnes DE, Lindahl T, McIlhatton M, Fishel R, Miller JH. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res. 2004 May 01; 64(9):3096-102. PMID: 15126346.
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    75. Calabrese P, Tavaré S, Shibata D. Pretumor progression: clonal evolution of human stem cell populations. Am J Pathol. 2004 Apr; 164(4):1337-46. PMID: 15039221.
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    76. Kim KM, Calabrese P, Tavaré S, Shibata D. Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol. 2004 Apr; 164(4):1369-77. PMID: 15039224.
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    77. Kim KM, Shibata D. Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon. BMC Gastroenterol. 2004 Apr 01; 4:8. PMID: 15059289.
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    78. Calabrese P, Tsao JL, Yatabe Y, Salovaara R, Mecklin JP, Järvinen HJ, Aaltonen LA, Tavaré S, Shibata D. Colorectal pretumor progression before and after loss of DNA mismatch repair. Am J Pathol. 2004 Apr; 164(4):1447-53. PMID: 15039232.
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    79. Quach N, Goodman MF, Shibata D. In vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR. BMC Clin Pathol. 2004 Feb 12; 4(1):1. PMID: 15028125.
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    80. Karanjawala ZE, Adachi N, Irvine RA, Oh EK, Shibata D, Schwarz K, Hsieh CL, Lieber MR. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst). 2002 Dec 05; 1(12):1017-26. PMID: 12531011.
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    81. Shibata D. Molecular tumour clocks and colorectal cancer: seeing the unseen. Pathology. 2002 Dec; 34(6):534-40. PMID: 12555991.
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    82. Tsao JL, Dudley S, Kwok B, Nickel AE, Laird PW, Siegmund KD, Liskay RM, Shibata D. Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis. 2002 Nov; 23(11):1807-10. PMID: 12419828.
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    83. Kim KM, Shibata D. Methylation reveals a niche: stem cell succession in human colon crypts. Oncogene. 2002 Aug 12; 21(35):5441-9. PMID: 12154406.
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    84. Trinh BN, Long TI, Nickel AE, Shibata D, Laird PW. DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol. 2002 May; 22(9):2906-17. PMID: 11940649.
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    85. Kim KM, Salovaara R, Mecklin JP, Järvinen HJ, Aaltonen LA, Shibata D. PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper. Am J Pathol. 2002 Apr; 160(4):1503-6. PMID: 11943734.
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    86. Laiho P, Launonen V, Lahermo P, Esteller M, Guo M, Herman JG, Mecklin JP, Järvinen H, Sistonen P, Kim KM, Shibata D, Houlston RS, Aaltonen LA. Low-level microsatellite instability in most colorectal carcinomas. Cancer Res. 2002 Feb 15; 62(4):1166-70. PMID: 11861399.
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    87. Selaru FM, Zou T, Xu Y, Shustova V, Yin J, Mori Y, Sato F, Wang S, Olaru A, Shibata D, Greenwald BD, Krasna MJ, Abraham JM, Meltzer SJ. Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays. Oncogene. 2002 Jan 17; 21(3):475-8. PMID: 11821959.
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    88. Wu AH, Shibata D, Yu MC, Lai MY, Ross RK. Dietary heterocyclic amines and microsatellite instability in colon adenocarcinomas. Carcinogenesis. 2001 Oct; 22(10):1681-4. PMID: 11577009.
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    89. Shibata D, Lewis JJ, Leung DH, Brennan MF. Is there a role for incomplete resection in the management of retroperitoneal liposarcomas? J Am Coll Surg. 2001 Oct; 193(4):373-9. PMID: 11584964.
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    90. Yatabe Y, Tavaré S, Shibata D. Investigating stem cells in human colon by using methylation patterns. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10839-44. PMID: 11517339.
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    91. Markl ID, Cheng J, Liang G, Shibata D, Laird PW, Jones PA. Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time. Cancer Res. 2001 Aug 01; 61(15):5875-84. PMID: 11479229.
      View in: PubMed
    92. Xiong Z, Wu AH, Bender CM, Tsao JL, Blake C, Shibata D, Jones PA, Yu MC, Ross RK, Laird PW. Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas. Cancer Epidemiol Biomarkers Prev. 2001 Jul; 10(7):799-803. PMID: 11440966.
      View in: PubMed
    93. Vilkki S, Tsao JL, Loukola A, Pöyhönen M, Vierimaa O, Herva R, Aaltonen LA, Shibata D. Extensive somatic microsatellite mutations in normal human tissue. Cancer Res. 2001 Jun 01; 61(11):4541-4. PMID: 11389087.
      View in: PubMed
    94. Blake C, Tsao JL, Wu A, Shibata D. Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers. Am J Pathol. 2001 May; 158(5):1867-70. PMID: 11337385.
      View in: PubMed
    95. Shibata D. Talking tumours: histories from sequences. Ann Med. 2001 Mar; 33(2):148-52. PMID: 11327118.
      View in: PubMed
    96. Shibata D. The SURF Technique : Selective Genetic Analysis of Microscopic Tissue Heterogeneity. Methods Mol Med. 2001; 50:59-67. PMID: 21318816.
      View in: PubMed
    97. Shibata D, Aaltonen LA. Genetic predisposition and somatic diversification in tumor development and progression. Adv Cancer Res. 2001; 80:83-114. PMID: 11034541.
      View in: PubMed
    98. Tsao JL, Yatabe Y, Markl ID, Hajyan K, Jones PA, Shibata D. Bladder cancer genotype stability during clinical progression. Genes Chromosomes Cancer. 2000 Sep; 29(1):26-32. PMID: 10918390.
      View in: PubMed
    99. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Blake C, Shibata D, Danenberg PV, Laird PW. MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res. 2000 Apr 15; 28(8):E32. PMID: 10734209.
      View in: PubMed
    100. Qin X, Shibata D, Gerson SL. Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea. Carcinogenesis. 2000 Apr; 21(4):833-8. PMID: 10753224.
      View in: PubMed
    101. Higano S, Shrier DA, Numaguchi Y, Shibata DK, Kwok E. Characteristics and pitfalls of contrast-enhanced, T1-weighted magnetization transfer images of the brain. Acad Radiol. 2000 Mar; 7(3):156-64. PMID: 10730810.
      View in: PubMed
    102. Ireland AP, Shibata DK, Chandrasoma P, Lord RV, Peters JH, DeMeester TR. Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia. Ann Surg. 2000 Feb; 231(2):179-87. PMID: 10674608.
      View in: PubMed
    103. Tsao JL, Yatabe Y, Salovaara R, Järvinen HJ, Mecklin JP, Aaltonen LA, Tavaré S, Shibata D. Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1236-41. PMID: 10655514.
      View in: PubMed
    104. Shibata D, Brophy DP, Gordon FD, Anastopoulos HT, Sentovich SM, Bleday R. Transjugular intrahepatic portosystemic shunt for treatment of bleeding ectopic varices with portal hypertension. Dis Colon Rectum. 1999 Dec; 42(12):1581-5. PMID: 10613477.
      View in: PubMed
    105. Chu PG, Chang KL, Chen WG, Chen YY, Shibata D, Hayashi K, Bacchi C, Bacchi M, Weiss LM. Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different populations. Am J Pathol. 1999 Sep; 155(3):941-7. PMID: 10487851.
      View in: PubMed
    106. Tsao JL, Tavaré S, Salovaara R, Jass JR, Aaltonen LA, Shibata D. Colorectal adenoma and cancer divergence. Evidence of multilineage progression. Am J Pathol. 1999 Jun; 154(6):1815-24. PMID: 10362806.
      View in: PubMed
    107. Liu YG, Shirano Y, Fukaki H, Yanai Y, Tasaka M, Tabata S, Shibata D. Complementation of plant mutants with large genomic DNA fragments by a transformation-competent artificial chromosome vector accelerates positional cloning. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6535-40. PMID: 10339623.
      View in: PubMed
    108. Sawa S, Watanabe K, Goto K, Liu YG, Shibata D, Kanaya E, Morita EH, Okada K. FILAMENTOUS FLOWER, a meristem and organ identity gene of Arabidopsis, encodes a protein with a zinc finger and HMG-related domains. Genes Dev. 1999 May 01; 13(9):1079-88. PMID: 10323860.
      View in: PubMed
    109. Fein M, Peters JH, Baril N, McGarvey M, Chandrasoma P, Shibata D, Laird PW, Skinner KA. Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal reflux. J Surg Res. 1999 May 01; 83(1):48-55. PMID: 10210642.
      View in: PubMed
    110. Shibata D. Pattern recognition and arrays: the times are a-changing. Am J Pathol. 1999 Apr; 154(4):979-80. PMID: 10233834.
      View in: PubMed
    111. Tsao JL, Zhang J, Salovaara R, Li ZH, Järvinen HJ, Mecklin JP, Aaltonen LA, Shibata D. Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture. Am J Pathol. 1998 Oct; 153(4):1189-200. PMID: 9777950.
      View in: PubMed
    112. Chen YY, Chang KL, Chen WG, Shibata D, Hayashi K, Weiss LM. Epstein-Barr virus-associated nuclear antigen-1 carboxy-terminal gene sequences in Japanese and American patients with gastric carcinoma. Lab Invest. 1998 Jul; 78(7):877-82. PMID: 9690565.
      View in: PubMed
    113. Pories SE, Hess DT, Swenson K, Lotz M, Moussa R, Steele G, Shibata D, Rieger-Christ KM, Summerhayes C. Overexpression of pp60c-src elicits invasive behavior in rat colon epithelial cells. Gastroenterology. 1998 Jun; 114(6):1287-95. PMID: 9609766.
      View in: PubMed
    114. Baker SM, Harris AC, Tsao JL, Flath TJ, Bronner CE, Gordon M, Shibata D, Liskay RM. Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res. 1998 Mar 15; 58(6):1087-9. PMID: 9515784.
      View in: PubMed
    115. Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A, Liskay RM. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat Genet. 1998 Mar; 18(3):276-9. PMID: 9500552.
      View in: PubMed
    116. Shibata D. The SURF technique. Selective genetic analysis of microscopic tissue heterogeneity. Methods Mol Biol. 1998; 92:39-47. PMID: 9664501.
      View in: PubMed
    117. Shibata D. The dynamics of early intestinal tumour proliferation: to be or not to be. Cancer Surv. 1998; 32:181-200. PMID: 10489628.
      View in: PubMed
    118. Shibata D. Molecular tumor clocks and dynamic phenotype. Am J Pathol. 1997 Sep; 151(3):643-6. PMID: 9284810.
      View in: PubMed
    119. Tsao JL, Davis SD, Baker SM, Liskay RM, Shibata D. Intestinal stem cell division and genetic diversity. A computer and experimental analysis. Am J Pathol. 1997 Aug; 151(2):573-9. PMID: 9250170.
      View in: PubMed
    120. Arnheim N, Shibata D. DNA mismatch repair in mammals: role in disease and meiosis. Curr Opin Genet Dev. 1997 Jun; 7(3):364-70. PMID: 9229112.
      View in: PubMed
    121. Tsao Jl, Zhao Y, Lukas J, Yang X, Shah A, Press M, Shibata D. Telomerase activity in normal and neoplastic breast. Clin Cancer Res. 1997 Apr; 3(4):627-31. PMID: 9815730.
      View in: PubMed
    122. Gamberi B, Gaidano G, Parsa N, Carbone A, Roncella S, Knowles DM, Louie DC, Shibata D, Chaganti RS, Dalla-Favera R. Microsatellite instability is rare in B-cell non-Hodgkin's lymphomas. Blood. 1997 Feb 01; 89(3):975-9. PMID: 9028329.
      View in: PubMed
    123. Shibata D. Molecular tumour clocks. Ann Med. 1997 Feb; 29(1):5-7. PMID: 9073319.
      View in: PubMed
    124. Hemminki A, Tomlinson I, Markie D, Järvinen H, Sistonen P, Björkqvist AM, Knuutila S, Salovaara R, Bodmer W, Shibata D, de la Chapelle A, Aaltonen LA. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet. 1997 Jan; 15(1):87-90. PMID: 8988175.
      View in: PubMed
    125. Shibata D, Reale MA, Lavin P, Silverman M, Fearon ER, Steele G, Jessup JM, Loda M, Summerhayes IC. The DCC protein and prognosis in colorectal cancer. N Engl J Med. 1996 Dec 05; 335(23):1727-32. PMID: 8929264.
      View in: PubMed
    126. Shibata D. Loss of DNA mismatch repair: life in the fast lane? Gastroenterology. 1996 Aug; 111(2):519-21. PMID: 8690218.
      View in: PubMed
    127. Shibata DK. Epstein-Barr virus and gastric carcinoma. Jpn J Cancer Res. 1996 Aug; 87(8):Inside front cover. PMID: 8797882.
      View in: PubMed
    128. Li ZH, Aaltonen LA, Shu Q, Srivastava S, Grizzle WE, Shibata D. Effects of mutation and growth rates on patterns of microsatellite instability. Am J Pathol. 1996 Jun; 148(6):1757-61. PMID: 8669462.
      View in: PubMed
    129. Shibata D, Navidi W, Salovaara R, Li ZH, Aaltonen LA. Somatic microsatellite mutations as molecular tumor clocks. Nat Med. 1996 Jun; 2(6):676-81. PMID: 8640559.
      View in: PubMed
    130. Shah KV, Kessis TD, Shah F, Gupta JW, Shibata D, Jones RW. Human papillomavirus investigation of patients with cervical intraepithelial neoplasia 3, some of whom progressed to invasive cancer. Int J Gynecol Pathol. 1996 Apr; 15(2):127-30. PMID: 8786201.
      View in: PubMed
    131. Li ZH, Salovaara R, Aaltonen LA, Shibata D. Telomerase activity is commonly detected in hereditary nonpolyposis colorectal cancers. Am J Pathol. 1996 Apr; 148(4):1075-9. PMID: 8644849.
      View in: PubMed
    132. Douer D, Levine A, Anderson WF, Gordon M, Groshen S, Khan A, Mohrbacher A, Muggia F, Shibata D. High-dose chemotherapy and autologous bone marrow plus peripheral blood stem cell transplantation for patients with lymphoma or metastatic breast cancer: use of marker genes to investigate hematopoietic reconstitution in adults. Hum Gene Ther. 1996 Mar 20; 7(5):669-84. PMID: 8845392.
      View in: PubMed
    133. Levine AM, Bernstein L, Sullivan-Halley J, Shibata D, Mahterian SB, Nathwani BN. Role of zidovudine antiretroviral therapy in the pathogenesis of acquired immunodeficiency syndrome-related lymphoma. Blood. 1995 Dec 15; 86(12):4612-6. PMID: 8541552.
      View in: PubMed
    134. Burgart LJ, Zheng J, Shu Q, Strickler JG, Shibata D. Somatic mitochondrial mutation in gastric cancer. Am J Pathol. 1995 Oct; 147(4):1105-11. PMID: 7573355.
      View in: PubMed
    135. Mirchandani D, Zheng J, Miller GJ, Ghosh AK, Shibata DK, Cote RJ, Roy-Burman P. Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer. Am J Pathol. 1995 Jul; 147(1):92-101. PMID: 7604888.
      View in: PubMed
    136. Hernandez AM, Nathwani BN, Nguyen D, Shibata D, Chuan W, Nichols P, Taylor CR. Nodal benign and malignant monocytoid B cells with and without follicular lymphomas: a comparative study of follicular colonization, light chain restriction, bcl-2, and t(14;18) in 39 cases. Hum Pathol. 1995 Jun; 26(6):625-32. PMID: 7774892.
      View in: PubMed
    137. Levine PH, Stemmermann G, Lennette ET, Hildesheim A, Shibata D, Nomura A. Elevated antibody titers to Epstein-Barr virus prior to the diagnosis of Epstein-Barr-virus-associated gastric adenocarcinoma. Int J Cancer. 1995 Mar 03; 60(5):642-4. PMID: 7860138.
      View in: PubMed
    138. Mack TM, Cozen W, Shibata DK, Weiss LM, Nathwani BN, Hernandez AM, Taylor CR, Hamilton AS, Deapen DM, Rappaport EB. Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease. N Engl J Med. 1995 Feb 16; 332(7):413-8. PMID: 7824015.
      View in: PubMed
    139. Hernandez AM, Shibata D. Epstein-Barr virus-associated non-Hodgkin's lymphoma in HIV-infected patients. Leuk Lymphoma. 1995 Jan; 16(3-4):217-21. PMID: 7719229.
      View in: PubMed
    140. Zheng J, Shu Q, Li ZH, Tsao JI, Weiss LM, Shibata D. Patterns of p53 mutations in squamous cell carcinoma of the lung. Acquisition at a relatively early age. Am J Pathol. 1994 Dec; 145(6):1444-9. PMID: 7992847.
      View in: PubMed
    141. Chang KL, Arber DA, Shibata D, Rappaport H, Weiss LM. Follicular small lymphocytic lymphoma. Am J Surg Pathol. 1994 Oct; 18(10):999-1009. PMID: 8092400.
      View in: PubMed
    142. Liu Y, Hernandez AM, Shibata D, Cortopassi GA. BCL2 translocation frequency rises with age in humans. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8910-4. PMID: 8090743.
      View in: PubMed
    143. Strickler JG, Zheng J, Shu Q, Burgart LJ, Alberts SR, Shibata D. p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res. 1994 Sep 01; 54(17):4750-5. PMID: 8062274.
      View in: PubMed
    144. Shibata D. Biologic aspects of AIDS-related lymphoma. Curr Opin Oncol. 1994 Sep; 6(5):503-7. PMID: 7827154.
      View in: PubMed
    145. Tsao J, Shibata D. Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC. Am J Pathol. 1994 Sep; 145(3):531-4. PMID: 8080037.
      View in: PubMed
    146. Duggan BD, Felix JC, Muderspach LI, Tourgeman D, Zheng J, Shibata D. Microsatellite instability in sporadic endometrial carcinoma. J Natl Cancer Inst. 1994 Aug 17; 86(16):1216-21. PMID: 8040889.
      View in: PubMed
    147. Gaidano G, Lo Coco F, Ye BH, Shibata D, Levine AM, Knowles DM, Dalla-Favera R. Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: association with diffuse large-cell subtype. Blood. 1994 Jul 15; 84(2):397-402. PMID: 8025268.
      View in: PubMed
    148. Clark HM, Yano T, Otsuki T, Jaffe ES, Shibata D, Raffeld M. Mutations in the coding region of c-MYC in AIDS-associated and other aggressive lymphomas. Cancer Res. 1994 Jul 01; 54(13):3383-6. PMID: 8012955.
      View in: PubMed
    149. Wang WH, Takano T, Shibata D, Kitamura K, Takeda G. Molecular basis of a null mutation in soybean lipoxygenase 2: substitution of glutamine for an iron-ligand histidine. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):5828-32. PMID: 8016074.
      View in: PubMed
    150. Shibata D. Extraction of DNA from paraffin-embedded tissue for analysis by polymerase chain reaction: new tricks from an old friend. Hum Pathol. 1994 Jun; 25(6):561-3. PMID: 8013945.
      View in: PubMed
    151. Duggan BD, Felix JC, Muderspach LI, Tsao JL, Shibata DK. Early mutational activation of the c-Ki-ras oncogene in endometrial carcinoma. Cancer Res. 1994 Mar 15; 54(6):1604-7. PMID: 8137266.
      View in: PubMed
    152. Shibata D, Peinado MA, Ionov Y, Malkhosyan S, Perucho M. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet. 1994 Mar; 6(3):273-81. PMID: 8012390.
      View in: PubMed
    153. Hansmann ML, Shibata D, Lorenzen J, Hell K, Nathwani BN, Fischer R. Incidence of Epstein-Barr virus bcl-2 expression and chromosomal translocation t(14;18) in large cell lymphoma associated with paragranuloma (lymphocyte-predominant Hodgkin's disease). Hum Pathol. 1994 Mar; 25(3):240-3. PMID: 8150454.
      View in: PubMed
    154. Peng YL, Shirano Y, Ohta H, Hibino T, Tanaka K, Shibata D. A novel lipoxygenase from rice. Primary structure and specific expression upon incompatible infection with rice blast fungus. J Biol Chem. 1994 Feb 04; 269(5):3755-61. PMID: 7508918.
      View in: PubMed
    155. Li ZH, Zheng J, Weiss LM, Shibata D. c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung. Am J Pathol. 1994 Feb; 144(2):303-9. PMID: 8311114.
      View in: PubMed
    156. Sueyoshi K, Goto M, Johnosono M, Sato E, Shibata D. Anatomical distribution of HTLV-I proviral sequence in an autopsy case of HTLV-I associated myelopathy: a polymerase chain reaction study. Pathol Int. 1994 Jan; 44(1):27-33. PMID: 8025646.
      View in: PubMed
    157. Shibata D. Selective ultraviolet radiation fractionation and polymerase chain reaction analysis of genetic alterations. Am J Pathol. 1993 Dec; 143(6):1523-6. PMID: 8256844.
      View in: PubMed
    158. Shibata D. Identification of mismatched fixed specimens with a commercially available kit based on the polymerase chain reaction. Am J Clin Pathol. 1993 Dec; 100(6):666-70. PMID: 8249915.
      View in: PubMed
    159. Shibata D, Schaeffer J, Li ZH, Capella G, Perucho M. Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas. J Natl Cancer Inst. 1993 Jul 07; 85(13):1058-63. PMID: 8515492.
      View in: PubMed
    160. Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature. 1993 Jun 10; 363(6429):558-61. PMID: 8505985.
      View in: PubMed
    161. Shibata D, Hawes D, Stemmermann GN, Weiss LM. Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii. Cancer Epidemiol Biomarkers Prev. 1993 May-Jun; 2(3):213-7. PMID: 8391356.
      View in: PubMed
    162. Shibata D, Weiss LM, Hernandez AM, Nathwani BN, Bernstein L, Levine AM. Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus. Blood. 1993 Apr 15; 81(8):2102-9. PMID: 8386027.
      View in: PubMed
    163. Chang KL, Chen YY, Shibata D, Weiss LM. Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues. Diagn Mol Pathol. 1992 Dec; 1(4):246-55. PMID: 1342973.
      View in: PubMed
    164. Levine AM, Shibata D, Sullivan-Halley J, Nathwani B, Brynes R, Slovak ML, Mahterian S, Riley CL, Weiss L, Levine PH. Epidemiological and biological study of acquired immunodeficiency syndrome-related lymphoma in the County of Los Angeles: preliminary results. Cancer Res. 1992 Oct 01; 52(19 Suppl):5482s-5484s. PMID: 1327509.
      View in: PubMed
    165. Goldschmidts WL, Bhatia K, Johnson JF, Akar N, Gutiérrez MI, Shibata D, Carolan M, Levine A, Magrath IT. Epstein-Barr virus genotypes in AIDS-associated lymphomas are similar to those in endemic Burkitt's lymphomas. Leukemia. 1992 Sep; 6(9):875-8. PMID: 1325581.
      View in: PubMed
    166. Arber DA, Shibata D, Chen YY, Weiss LM. Characterization of the topography of Epstein-Barr virus infection in human immunodeficiency virus-associated lymphoid tissues. Mod Pathol. 1992 Sep; 5(5):559-66. PMID: 1344820.
      View in: PubMed
    167. Shibata D, Hawes D, Li ZH, Hernandez AM, Spruck CH, Nichols PW. Specific genetic analysis of microscopic tissue after selective ultraviolet radiation fractionation and the polymerase chain reaction. Am J Pathol. 1992 Sep; 141(3):539-43. PMID: 1325739.
      View in: PubMed
    168. Cortopassi GA, Shibata D, Soong NW, Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7370-4. PMID: 1502147.
      View in: PubMed
    169. Pandey R, Ghosh AK, Kumar DV, Bachman BA, Shibata D, Roy-Burman P. Recombination between feline leukemia virus subgroup B or C and endogenous env elements alters the in vitro biological activities of the viruses. J Virol. 1992 Jun; 66(6):3976. PMID: 1316496.
      View in: PubMed
    170. Shibata D. PCR diagnostics of herpes-virus-group infections. Ann Med. 1992 Jun; 24(3):221-4. PMID: 1320899.
      View in: PubMed
    171. Ohta H, Shirano Y, Tanaka K, Morita Y, Shibata D. cDNA cloning of rice lipoxygenase L-2 and characterization using an active enzyme expressed from the cDNA in Escherichia coli. Eur J Biochem. 1992 Jun 01; 206(2):331-6. PMID: 1597177.
      View in: PubMed
    172. Weiss LM, Jaffe ES, Liu XF, Chen YY, Shibata D, Medeiros LJ. Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Blood. 1992 Apr 01; 79(7):1789-95. PMID: 1373088.
      View in: PubMed
    173. Shibata D, Weiss LM. Epstein-Barr virus-associated gastric adenocarcinoma. Am J Pathol. 1992 Apr; 140(4):769-74. PMID: 1314023.
      View in: PubMed
    174. Lorenzen J, Hansmann ML, Shibata D, Hell K, Klöckner A, Pezzella F, Fischer R. [Bcl-2 in potentials precursors of nodular paragranuloma and its dedifferentiated variant (large cell B-lymphoma)]. Verh Dtsch Ges Pathol. 1992; 76:169-72. PMID: 1283252.
      View in: PubMed
    175. Weiss LM, Chen YY, Liu XF, Shibata D. Epstein-Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study. Am J Pathol. 1991 Dec; 139(6):1259-65. PMID: 1661073.
      View in: PubMed
    176. Pandey R, Ghosh AK, Kumar DV, Bachman BA, Shibata D, Roy-Burman P. Recombination between feline leukemia virus subgroup B or C and endogenous env elements alters the in vitro biological activities of the viruses. J Virol. 1991 Dec; 65(12):6495-508. PMID: 1658356.
      View in: PubMed
    177. Shibata D, Hansmann ML, Weiss LM, Nathwani BN. Epstein-Barr virus infections and Hodgkin's disease: a study of fixed tissues using the polymerase chain reaction. Hum Pathol. 1991 Dec; 22(12):1262-7. PMID: 1660852.
      View in: PubMed
    178. Shibata D, Tokunaga M, Uemura Y, Sato E, Tanaka S, Weiss LM. Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma. Am J Pathol. 1991 Sep; 139(3):469-74. PMID: 1653517.
      View in: PubMed
    179. Weiss LM, Gaffey MJ, Shibata D. Lymphoepithelioma-like carcinoma and its relationship to Epstein-Barr virus. Am J Clin Pathol. 1991 Aug; 96(2):156-8. PMID: 1650531.
      View in: PubMed
    180. Shibata D, Kurosu M, Noguchi TT. Fixed human tissues: a resource for the identification of individuals. J Forensic Sci. 1991 Jul; 36(4):1204-12. PMID: 1919478.
      View in: PubMed
    181. Shibata D, Tokunaga M, Sasaki N, Nanba K. Detection of human T-cell leukemia virus type I proviral sequences from fixed tissues of seropositive patients. Am J Clin Pathol. 1991 Apr; 95(4):536-9. PMID: 2014780.
      View in: PubMed
    182. Shibata D, Weiss LM, Nathwani BN, Brynes RK, Levine AM. Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma. Blood. 1991 Apr 01; 77(7):1527-33. PMID: 1849034.
      View in: PubMed
    183. Shibata D, Kato T, Tanaka K. Nucleotide sequences of a soybean lipoxygenase gene and the short intergenic region between an upstream lipoxygenase gene. Plant Mol Biol. 1991 Feb; 16(2):353-9. PMID: 1909908.
      View in: PubMed
    184. Liang R, Shibata D. Epstein-Barr virus and T-cell lymphoma. Am J Hematol. 1991 Feb; 36(2):160. PMID: 1849349.
      View in: PubMed
    185. Shibata D, Namiki T, Higuchi R. Identification of a mislabeled fixed specimen by DNA analysis. Am J Surg Pathol. 1990 Nov; 14(11):1076-8. PMID: 2240357.
      View in: PubMed
    186. Sakamoto A, Takeba G, Shibata D, Tanaka K. Phytochrome-mediated activation of the gene for cytosolic glutamine-synthetase (GS1) during imbibition of photosensitive lettuce seeds. Plant Mol Biol. 1990 Aug; 15(2):317-23. PMID: 1983300.
      View in: PubMed
    187. Shibata D, Capella G, Perucho M. Mutational activation of the c-K-ras gene in human pancreatic carcinoma. Baillieres Clin Gastroenterol. 1990 Mar; 4(1):151-69. PMID: 1976394.
      View in: PubMed
    188. Shibata D, Almoguera C, Forrester K, Dunitz J, Martin SE, Cosgrove MM, Perucho M, Arnheim N. Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas. Cancer Res. 1990 Feb 15; 50(4):1279-83. PMID: 2404591.
      View in: PubMed
    189. Shibata D, Hu E, Weiss LM, Brynes RK, Nathwani BN. Detection of specific t(14;18) chromosomal translocations in fixed tissues. Hum Pathol. 1990 Feb; 21(2):199-203. PMID: 2307446.
      View in: PubMed
    190. Shibata D, Nichols P, Sherrod A, Rabinowitz A, Bernstein-Singer L, Hu E. Detection of occult CNS involvement of follicular small cleaved lymphoma by the polymerase chain reaction. Mod Pathol. 1990 Jan; 3(1):71-5. PMID: 2308923.
      View in: PubMed
    191. Shibata D, Brynes RK, Rabinowitz A, Hanson CA, Slovak ML, Spira TJ, Gill P. Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1). Ann Intern Med. 1989 Dec 01; 111(11):871-5. PMID: 2573306.
      View in: PubMed
    192. Sakamoto A, Ogawa M, Masumura T, Shibata D, Takeba G, Tanaka K, Fujii S. Three cDNA sequences coding for glutamine synthetase polypeptides in Oryza sativa L. Plant Mol Biol. 1989 Nov; 13(5):611-4. PMID: 2577497.
      View in: PubMed
    193. Shibata D, Klatt EC. Analysis of human immunodeficiency virus and cytomegalovirus infection by polymerase chain reaction in the acquired immunodeficiency syndrome. An autopsy study. Arch Pathol Lab Med. 1989 Nov; 113(11):1239-44. PMID: 2554843.
      View in: PubMed
    194. Shibata D, Brynes RK, Nathwani B, Kwok S, Sninsky J, Arnheim N. Human immunodeficiency viral DNA is readily found in lymph node biopsies from seropositive individuals. Analysis of fixed tissue using the polymerase chain reaction. Am J Pathol. 1989 Oct; 135(4):697-702. PMID: 2679114.
      View in: PubMed
    195. Klatt EC, Shibata D, Strigle SM. Postmortem enzyme immunoassay for human immunodeficiency virus. Arch Pathol Lab Med. 1989 May; 113(5):485-7. PMID: 2653271.
      View in: PubMed
    196. Kiyabu MT, Shibata D, Arnheim N, Martin WJ, Fitzgibbons PL. Detection of human papillomavirus in formalin-fixed, invasive squamous carcinomas using the polymerase chain reaction. Am J Surg Pathol. 1989 Mar; 13(3):221-4. PMID: 2537583.
      View in: PubMed
    197. Shibata D, Cosgrove M, Arnheim N, Martin WJ, Martin SE. Detection of human papillomavirus DNA in fine-needle aspirations of metastatic squamous-cell carcinoma of the uterine cervix using the polymerase chain reaction. Diagn Cytopathol. 1989; 5(1):40-3. PMID: 2541988.
      View in: PubMed
    198. Shibata D, Martin WJ, Appleman MD, Causey DM, Leedom JM, Arnheim N. Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis. 1988 Dec; 158(6):1185-92. PMID: 2848898.
      View in: PubMed
    199. Shibata D, Fu YS, Gupta JW, Shah KV, Arnheim N, Martin WJ. Detection of human papillomavirus in normal and dysplastic tissue by the polymerase chain reaction. Lab Invest. 1988 Oct; 59(4):555-9. PMID: 2845193.
      View in: PubMed
    200. Shibata D, Martin WJ, Arnheim N. Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology. Cancer Res. 1988 Aug 15; 48(16):4564-6. PMID: 2840197.
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    201. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988 May 20; 53(4):549-54. PMID: 2453289.
      View in: PubMed
    202. Shibata D, Steczko J, Dixon JE, Andrews PC, Hermodson M, Axelrod B. Primary structure of soybean lipoxygenase L-2. J Biol Chem. 1988 May 15; 263(14):6816-21. PMID: 2834391.
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    203. Klatt EC, Shibata D. Cytomegalovirus infection in the acquired immunodeficiency syndrome. Clinical and autopsy findings. Arch Pathol Lab Med. 1988 May; 112(5):540-4. PMID: 2833874.
      View in: PubMed
    204. Shibata DK, Arnheim N, Martin WJ. Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. J Exp Med. 1988 Jan 01; 167(1):225-30. PMID: 2826637.
      View in: PubMed
    205. Chandrasoma P, Shibata D, Radin R, Brown LP, Koss M. Malignant peripheral nerve sheath tumor arising in an adrenal ganglioneuroma in an adult male homosexual. Cancer. 1986 May 15; 57(10):2022-5. PMID: 3955508.
      View in: PubMed
    206. Jacobs KA, Albright LM, Shibata DK, Geiduschek EP. Genetic complementation by cloned bacteriophage T4 late genes. J Virol. 1981 Jul; 39(1):31-45. PMID: 6456362.
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