Darryl Shibata, MD

Title(s)Professor of Pathology
AddressNOR 1441 Eastlake Ave
Health Sciences Campus
Los Angeles CA 90089-9092
Phone+1 323 865 3298
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    After attending UCLA for his undergraduate degree, Dr. Shibata obtained his medical degree from the Keck School of Medicine of USC. After completing his internship training in pediatrics from UC San Diego, Dr. Shibata returned to USC for his residency and fellowship at LAC+USC Medical Center. Currently, Dr. Shibata has clinical appointments at both LAC+USC Medical Center and USC/Norris Comprehensive Cancer Center. In addition to his wide array of responsibilities in the research, education and practitioner capacities, Dr. Shibata sits on the editorial board of the BMC Cancer Journal and the American Journal of Pathology.

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    Arizona Cancer and Evolution Center (ACE)
    NIH U54CA217376Apr 12, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    Born to be Bad: Is Abnormal Cell Mobility Already Present At Initiation?
    NIH R21CA185016Jul 30, 2014 - May 31, 2018
    Role: Principal Investigator
    How Do NSAIDs Prevent Colorectal Cancer
    NIH R21CA170814Sep 13, 2012 - Aug 31, 2015
    Role: Principal Investigator
    Tumor Diversity As A Biomarker For Colorectal Cancer
    NIH R21CA149990Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    How Do Colorectal Cancers Arise Despite Surveillance?
    NIH R33CA111940Aug 1, 2005 - Jun 30, 2010
    Role: Principal Investigator
    HUMAN COLON STEM CELL AND CRYPT DYNAMICS
    NIH R21DK061140Sep 30, 2001 - Aug 31, 2005
    Role: Principal Investigator
    Fixing Fixed DNA
    NIH R21CA091301Jul 1, 2001 - Jun 30, 2004
    Role: Principal Investigator
    Mouse Models of Early Intestinal Neoplasia
    NIH R01CA080077Jan 1, 1999 - Mar 31, 2010
    Role: Principal Investigator
    PATHOLOGY OF TUMOR GROWTH
    NIH R01CA070858May 21, 1997 - Apr 30, 2001
    Role: Principal Investigator
    PATHOLOGY OF TUMOR GROWTH
    NIH R55CA070858Sep 15, 1996 - Apr 30, 1997
    Role: Principal Investigator
    PATHOLOGY OF GASTRIC CANCER
    NIH R01CA058704Feb 1, 1993 - Jan 31, 1999
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Navigating the path to distant metastasis. Nat Genet. 2020 07; 52(7):642-643. Graham TA, Shibata D. PMID: 32632324.
      View in: PubMed   Mentions: 1     Fields:    
    2. Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography. iScience. 2020 Jul 24; 23(7):101304. Shibata D. PMID: 32623333.
      View in: PubMed   Mentions:
    3. Deep learned tissue "fingerprints" classify breast cancers by ER/PR/Her2 status from H&E images. Sci Rep. 2020 04 29; 10(1):7275. Rawat RR, Ortega I, Roy P, Sha F, Shibata D, Ruderman D, Agus DB. PMID: 32350370.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    4. Minimal barriers to invasion during human colorectal tumor growth. Nat Commun. 2020 03 09; 11(1):1280. Ryser MD, Mallo D, Hall A, Hardman T, King LM, Tatishchev S, Sorribes IC, Maley CC, Marks JR, Hwang ES, Shibata D. PMID: 32152322.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation. JCO Clin Cancer Inform. 2020 02; 4:100-107. Hvitfeldt E, Xia C, Siegmund KD, Shibata D, Marjoram P. PMID: 32078366.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Mutational signatures in colon cancer. BMC Res Notes. 2019 Dec 03; 12(1):788. Pandey P, Yang Z, Shibata D, Marjoram P, Siegmund KD. PMID: 31796096.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. HiLDA: a statistical approach to investigate differences in mutational signatures. PeerJ. 2019; 7:e7557. Yang Z, Pandey P, Shibata D, Conti DV, Marjoram P, Siegmund KD. PMID: 31523512.
      View in: PubMed   Mentions:
    8. Cancer cell evolution through the ages. Science. 2019 08 02; 365(6452):440-441. Maley CC, Shibata D. PMID: 31371596.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution. Mol Biol Evol. 2019 07 01; 36(7):1430-1441. Chen B, Shi Z, Chen Q, Shen X, Shibata D, Wen H, Wu CI. PMID: 30912799.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Somatic cell evolution: how to improve with age. J Pathol. 2019 Jan; 247(1):3-5. Shibata D. PMID: 30246391.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    11. Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. Sci Rep. 2018 11 23; 8(1):17292. Ryser MD, Yu M, Grady W, Siegmund K, Shibata D. PMID: 30470817.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Evolutionary Stem Cell Poker and Cancer Risks: The Paradox of The Large And Small Intestines. Curr Pathobiol Rep. 2018 Sep; 6(3):193-198. Shibata D. PMID: 30713810.
      View in: PubMed   Mentions:
    13. Spatial mutation patterns as markers of early colorectal tumor cell mobility. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5774-5779. Ryser MD, Min BH, Siegmund KD, Shibata D. PMID: 29760052.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    14. Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 10; 17(10):605-619. Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu CI, Schiffman JD, Hwang ES, Polyak K, Anderson ARA, Brown JS, Greaves M, Shibata D. PMID: 28912577.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    15. Between-region genetic divergence reflects the mode and tempo of tumor evolution. Nat Genet. 2017 Jul; 49(7):1015-1024. Sun R, Hu Z, Sottoriva A, Graham TA, Harpak A, Ma Z, Fischer JM, Shibata D, Curtis C. PMID: 28581503.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    16. Early mutation bursts in colorectal tumors. PLoS One. 2017; 12(3):e0172516. Zhao J, Salomon MP, Shibata D, Curtis C, Siegmund K, Marjoram P. PMID: 28257429.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Single cell lineage tracing reveals a role for TgfßR2 in intestinal stem cell dynamics and differentiation. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12192-12197. Fischer JM, Calabrese PP, Miller AJ, Muñoz NM, Grady WM, Shibata D, Liskay RM. PMID: 27791005.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. At least two well-spaced samples are needed to genotype a solid tumor. BMC Cancer. 2016 Mar 25; 16:250. Siegmund K, Shibata D. PMID: 27015839.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. HistoMosaic Detecting KRAS G12V Mutation Across Colorectal Cancer Tissue Slices through in Situ PCR. Anal Chem. 2016 Mar 01; 88(5):2792-8. Raub CB, Lee CC, Shibata D, Taylor C, Kartalov E. PMID: 26820161.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Derivation of induced pluripotent stem cells from orangutan skin fibroblasts. BMC Res Notes. 2015 Oct 16; 8:577. Ramaswamy K, Yik WY, Wang XM, Oliphant EN, Lu W, Shibata D, Ryder OA, Hacia JG. PMID: 26475477.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities. Stem Cell Res Ther. 2015 Aug 29; 6:158. Wang XM, Yik WY, Zhang P, Lu W, Huang N, Kim BR, Shibata D, Zitting M, Chow RH, Moser AB, Steinberg SJ, Hacia JG. PMID: 26319495.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Many private mutations originate from the first few divisions of a human colorectal adenoma. J Pathol. 2015 Nov; 237(3):355-62. Kang H, Salomon MP, Sottoriva A, Zhao J, Toy M, Press MF, Curtis C, Marjoram P, Siegmund K, Shibata D. PMID: 26119426.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    23. Can oncology recapitulate paleontology? Lessons from species extinctions. Nat Rev Clin Oncol. 2015 May; 12(5):273-85. Walther V, Hiley CT, Shibata D, Swanton C, Turner PE, Maley CC. PMID: 25687908.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    24. A Big Bang model of human colorectal tumor growth. Nat Genet. 2015 Mar; 47(3):209-16. Sottoriva A, Kang H, Ma Z, Graham TA, Salomon MP, Zhao J, Marjoram P, Siegmund K, Press MF, Shibata D, Curtis C. PMID: 25665006.
      View in: PubMed   Mentions: 325     Fields:    Translation:Humans
    25. Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):78-80. Siddiqi IN, Shibata D. PMID: 25153495.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45. Zhao J, Siegmund KD, Shibata D, Marjoram P. PMID: 24907673.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    27. Deep sequencing reveals lack of a clonal relationship between a metachronous classical hodgkin and diffuse large B-cell lymphoma. Clin Lymphoma Myeloma Leuk. 2014 Jun; 14(3):e87-93. Siddiqi IN, Ailawadhi S, Huang Q, Shibata RK, Kang H, Shibata D. PMID: 24548610.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection. Front Oncol. 2013 Oct 14; 3:264. Kang H, Shibata D. PMID: 24133655.
      View in: PubMed   Mentions:
    29. Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis. 2014 Jan; 35(1):237-46. Fischer JM, Schepers AG, Clevers H, Shibata D, Liskay RM. PMID: 23996931.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    30. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science. 2013 Feb 01; 339(6119):543-8. Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, Brown AM, Ng K, Ma J, Wienholds E, Dunant C, Pollett A, Gallinger S, McPherson J, Mullighan CG, Shibata D, Dick JE. PMID: 23239622.
      View in: PubMed   Mentions: 275     Fields:    Translation:HumansAnimalsCells
    31. Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. Cancer Res. 2013 Jan 01; 73(1):41-9. Sottoriva A, Spiteri I, Shibata D, Curtis C, Tavaré S. PMID: 23090114.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    32. The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis. Stem Cell Res Ther. 2012 Oct 04; 3(5):39. Wang XM, Yik WY, Zhang P, Lu W, Dranchak PK, Shibata D, Steinberg SJ, Hacia JG. PMID: 23036268.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Cancer. Heterogeneity and tumor history. Science. 2012 Apr 20; 336(6079):304-5. Shibata D. PMID: 22517848.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    34. Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells. DNA Cell Biol. 2012 Jun; 31(6):893-907. Tsai AG, Chen DM, Lin M, Hsieh JC, Okitsu CY, Taghva A, Shibata D, Hsieh CL. PMID: 22277069.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    35. The role of theorem proving in systems biology. J Theor Biol. 2012 May 07; 300:57-61. Wolkenhauer O, Shibata D, Mesarovic MD. PMID: 22244914.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    36. Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors. PLoS One. 2011; 6(10):e25985. Wang X, Kang GH, Campan M, Weisenberger DJ, Long TI, Cozen W, Bernstein L, Wu AH, Siegmund KD, Shibata D, Laird PW. PMID: 22028801.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    37. Molecular tumor clocks to study the evolution of drug resistance. Mol Pharm. 2011 Dec 05; 8(6):2050-4. Shibata D. PMID: 21732670.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. PLoS One. 2011; 6(6):e21657. Siegmund KD, Marjoram P, Tavaré S, Shibata D. PMID: 21738754.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    39. Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis. 2011 Jun; 32(6):829-35. Oghamian S, Sodir NM, Bashir MU, Shen H, Cullins AE, Carroll CA, Kundu P, Shibata D, Laird PW. PMID: 21362628.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    40. A stem cell niche dominance theorem. BMC Syst Biol. 2011 Jan 08; 5:4. Wolkenhauer O, Shibata DK, Mesarovic MD. PMID: 21214945.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    41. Mutation and epigenetic molecular clocks in cancer. Carcinogenesis. 2011 Feb; 32(2):123-8. Shibata D. PMID: 21076057.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    42. Using DNA methylation patterns to infer tumor ancestry. PLoS One. 2010 Aug 09; 5(8):e12002. Hong YJ, Marjoram P, Shibata D, Siegmund KD. PMID: 20711251.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    43. Is there any genetic instability in human cancer? DNA Repair (Amst). 2010 Aug 05; 9(8):858; discussion 859-60. Shibata D, Lieber MR. PMID: 20605538.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    44. Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27. Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia JG. PMID: 20069569.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    45. Hormone therapy, DNA methylation and colon cancer. Carcinogenesis. 2010 Jun; 31(6):1060-7. Wu AH, Siegmund KD, Long TI, Cozen W, Wan P, Tseng CC, Shibata D, Laird PW. PMID: 20064828.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    46. A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. BMC Cancer. 2010 Jan 05; 10:3. Calabrese P, Shibata D. PMID: 20051132.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    47. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan 01; 70(1):12-3. Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. PMID: 20028868.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    48. Many colorectal cancers are "flat" clonal expansions. . 2009 Jul 15; 8(14):2187-93. Siegmund KD, Marjoram P, Tavaré S, Shibata D. PMID: 19556889.
      View in: PubMed   Mentions:
    49. Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4828-33. Siegmund KD, Marjoram P, Woo YJ, Tavaré S, Shibata D. PMID: 19261858.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    50. Older individuals appear to acquire mitotically older colorectal cancers. J Pathol. 2009 Mar; 217(4):483-8. Woo YJ, Siegmund KD, Tavaré S, Shibata D. PMID: 19165870.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    51. Water intake and bladder cancer risk in Los Angeles County. Int J Cancer. 2008 Oct 01; 123(7):1649-56. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata DK, Conti DV, Gago-Dominguez M. PMID: 18623082.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    52. Modeling DNA methylation in a population of cancer cells. Stat Appl Genet Mol Biol. 2008; 7(1):Article 18. Siegmund KD, Marjoram P, Shibata D. PMID: 18597664.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    53. Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. J Transl Med. 2008 May 19; 6:26. Basile LA, Gallaher TK, Shibata D, Miller JD, Douer D. PMID: 18489769.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    54. Inferring relative numbers of human leucocyte genome replications. Br J Haematol. 2008 Jun; 141(6):862-71. Chu M, Siegmund KD, Hao QL, Crooks GM, Tavaré S, Shibata D. PMID: 18410448.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    55. Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5513-8. Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, Mecklin JP, Järvinen H, Eng C, Moeslein G, Shibata D, Houlston RS, Lucassen A, Tomlinson IP, Launonen V, Ristimäki A, Arango D, Karhu A, Sweeney HL, Aaltonen LA. PMID: 18391202.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    56. Tractable Cre-lox system for stochastic alteration of genes in mice. Nat Methods. 2008 Mar; 5(3):227-9. Miller AJ, Dudley SD, Tsao JL, Shibata D, Liskay RM. PMID: 18264106.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    57. Mistakes make history: visualizing intestinal tectonics. Gastroenterology. 2008 Feb; 134(2):628-31. Shibata D. PMID: 18242228.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    58. Stem cells as common ancestors in a colorectal cancer ancestral tree. Curr Opin Gastroenterol. 2008 Jan; 24(1):59-63. Shibata D. PMID: 18043234.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    59. Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis. Breast Dis. 2008; 29:15-25. Shibata DK, Kern SE. PMID: 19029621.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    60. The fuzzy math of solid tumor stem cells: a perspective. Cancer Res. 2007 Oct 01; 67(19):8985-8. Kern SE, Shibata D. PMID: 17908998.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    61. Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet. 2007 Jul 31; 8:50. Chu MW, Siegmund KD, Eckstam CL, Kim JY, Yang AS, Kanel GC, Tavaré S, Shibata D. PMID: 17672908.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    62. IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation. Exp Hematol. 2007 Feb; 35(2):203-13. Chen T, Burke KA, Zhan Y, Wang X, Shibata D, Zhao Y. PMID: 17258069.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    63. The stem cell population of the human colon crypt: analysis via methylation patterns. PLoS Comput Biol. 2007 Mar 02; 3(3):e28. Nicolas P, Kim KM, Shibata D, Tavaré S. PMID: 17335343.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    64. Stem cell chronicles: autobiographies within genomes. Stem Cell Rev. 2007 Jan; 3(1):94-103. Shibata D, Tavaré S. PMID: 17873386.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    65. Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res. 2006 Sep 01; 66(17):8430-8. Sodir NM, Chen X, Park R, Nickel AE, Conti PS, Moats R, Bading JR, Shibata D, Laird PW. PMID: 16951153.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    66. Clonal diversity in tumor progression. Nat Genet. 2006 Apr; 38(4):402-3. Shibata D. PMID: 16570060.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    67. Counting divisions in a human somatic cell tree: how, what and why? . 2006 Mar; 5(6):610-4. Shibata D, Tavaré S. PMID: 16582617.
      View in: PubMed   Mentions:
    68. Human hair genealogies and stem cell latency. BMC Biol. 2006 Feb 03; 4:2. Kim JY, Tavaré S, Shibata D. PMID: 16457718.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    69. When does MMR loss occur during HNPCC progression? Cancer Biomark. 2006; 2(1-2):29-35. Shibata D. PMID: 17192057.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    70. Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17739-44. Kim JY, Tavaré S, Shibata D. PMID: 16314580.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    71. Numbers of mutations to different types of colorectal cancer. BMC Cancer. 2005 Oct 03; 5:126. Calabrese P, Mecklin JP, Järvinen HJ, Aaltonen LA, Tavaré S, Shibata D. PMID: 16202134.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    72. Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice. Int J Cancer. 2005 Jul 01; 115(4):666-9. Kabbarah O, Sotelo AK, Mallon MA, Winkeler EL, Fan MY, Pfeifer JD, Shibata D, Gutmann DH, Goodfellow PJ. PMID: 15700306.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    73. Age-related human small intestine methylation: evidence for stem cell niches. BMC Med. 2005 Jun 23; 3:10. Kim JY, Siegmund KD, Tavaré S, Shibata D. PMID: 15975143.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    74. Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. BMC Gastroenterol. 2005 Jun 07; 5:19. Kim JY, Beart RW, Shibata D. PMID: 15941485.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    75. Generation and characterization of endonuclease G null mice. Mol Cell Biol. 2005 Jan; 25(1):294-302. Irvine RA, Adachi N, Shibata DK, Cassell GD, Yu K, Karanjawala ZE, Hsieh CL, Lieber MR. PMID: 15601850.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    76. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res. 2004 May 01; 64(9):3096-102. Xie Y, Yang H, Cunanan C, Okamoto K, Shibata D, Pan J, Barnes DE, Lindahl T, McIlhatton M, Fishel R, Miller JH. PMID: 15126346.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    77. Pretumor progression: clonal evolution of human stem cell populations. Am J Pathol. 2004 Apr; 164(4):1337-46. Calabrese P, Tavaré S, Shibata D. PMID: 15039221.
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    78. Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol. 2004 Apr; 164(4):1369-77. Kim KM, Calabrese P, Tavaré S, Shibata D. PMID: 15039224.
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    79. Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon. BMC Gastroenterol. 2004 Apr 01; 4:8. Kim KM, Shibata D. PMID: 15059289.
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    80. Colorectal pretumor progression before and after loss of DNA mismatch repair. Am J Pathol. 2004 Apr; 164(4):1447-53. Calabrese P, Tsao JL, Yatabe Y, Salovaara R, Mecklin JP, Järvinen HJ, Aaltonen LA, Tavaré S, Shibata D. PMID: 15039232.
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    81. In vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR. BMC Clin Pathol. 2004 Feb 12; 4(1):1. Quach N, Goodman MF, Shibata D. PMID: 15028125.
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    82. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst). 2002 Dec 05; 1(12):1017-26. Karanjawala ZE, Adachi N, Irvine RA, Oh EK, Shibata D, Schwarz K, Hsieh CL, Lieber MR. PMID: 12531011.
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    83. Molecular tumour clocks and colorectal cancer: seeing the unseen. Pathology. 2002 Dec; 34(6):534-40. Shibata D. PMID: 12555991.
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    84. Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis. 2002 Nov; 23(11):1807-10. Tsao JL, Dudley S, Kwok B, Nickel AE, Laird PW, Siegmund KD, Liskay RM, Shibata D. PMID: 12419828.
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    85. Methylation reveals a niche: stem cell succession in human colon crypts. Oncogene. 2002 Aug 12; 21(35):5441-9. Kim KM, Shibata D. PMID: 12154406.
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    86. DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol. 2002 May; 22(9):2906-17. Trinh BN, Long TI, Nickel AE, Shibata D, Laird PW. PMID: 11940649.
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    87. PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper. Am J Pathol. 2002 Apr; 160(4):1503-6. Kim KM, Salovaara R, Mecklin JP, Järvinen HJ, Aaltonen LA, Shibata D. PMID: 11943734.
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    88. Low-level microsatellite instability in most colorectal carcinomas. Cancer Res. 2002 Feb 15; 62(4):1166-70. Laiho P, Launonen V, Lahermo P, Esteller M, Guo M, Herman JG, Mecklin JP, Järvinen H, Sistonen P, Kim KM, Shibata D, Houlston RS, Aaltonen LA. PMID: 11861399.
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