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Chih-Lin Hsieh, PhD

Title(s)Professor of Urology
AddressNOR 5420
Health Sciences Campus
Los Angeles CA 90089-9176
Phone+1 323 865 0567
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    Other Positions
    Title(s)Catherine and Joseph Aresty Chair in Urologic Research


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    GENETIC HETEROGENEITY AMONG HUMAN SOMATIC CELLS AND ITS ACCUMULATION WITH AGE
    NIH/NIA R01AG067615Aug 1, 2020 - Apr 30, 2024
    Role: Principal Investigator
    TARGETS AND REQUIREMENTS OF METHYLATION IN HUMAN CELLS
    NIH/NIGMS R01GM060237Jul 1, 2000 - Jun 30, 2008
    Role: Principal Investigator
    IMPACT AND DYNAMICS OF DNA METHYLATION IN HUMAN CELLS
    NIH/NIGMS R01GM054781Sep 1, 1996 - Jun 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel Lines of Evidence for the Asymmetric Strand Displacement Model of Mitochondrial DNA Replication. Mol Cell Biol. 2019 01 15; 39(2). Hsieh CL. PMID: 30397074.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels. Genet Epidemiol. 2017 05; 41(4):297-308. Larson NB, McDonnell S, Cannon Albright L, Teerlink C, Stanford J, Ostrander EA, Isaacs WB, Xu J, Cooney KA, Lange E, Schleutker J, Carpten JD, Powell I, Bailey-Wilson JE, Cussenot O, Cancel-Tassin G, Giles GG, MacInnis RJ, Maier C, Whittemore AS, Hsieh CL, Wiklund F, Catalona WJ, Foulkes W, Mandal D, Eeles R, Kote-Jarai Z, Ackerman MJ, Olson TM, Klein CJ, Thibodeau SN, Schaid DJ. PMID: 28211093.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants. Am J Hum Genet. 2016 Oct 06; 99(4):877-885. Ioannidis NM, Rothstein JH, Pejaver V, Middha S, McDonnell SK, Baheti S, Musolf A, Li Q, Holzinger E, Karyadi D, Cannon-Albright LA, Teerlink CC, Stanford JL, Isaacs WB, Xu J, Cooney KA, Lange EM, Schleutker J, Carpten JD, Powell IJ, Cussenot O, Cancel-Tassin G, Giles GG, MacInnis RJ, Maier C, Hsieh CL, Wiklund F, Catalona WJ, Foulkes WD, Mandal D, Eeles RA, Kote-Jarai Z, Bustamante CD, Schaid DJ, Hastie T, Ostrander EA, Bailey-Wilson JE, Radivojac P, Thibodeau SN, Whittemore AS, Sieh W. PMID: 27666373.
      View in: PubMed   Mentions: 127     Fields:    Translation:Humans
    4. Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies. Genet Epidemiol. 2016 09; 40(6):461-9. Larson NB, McDonnell S, Albright LC, Teerlink C, Stanford J, Ostrander EA, Isaacs WB, Xu J, Cooney KA, Lange E, Schleutker J, Carpten JD, Powell I, Bailey-Wilson J, Cussenot O, Cancel-Tassin G, Giles G, MacInnis R, Maier C, Whittemore AS, Hsieh CL, Wiklund F, Catalona WJ, Foulkes W, Mandal D, Eeles R, Kote-Jarai Z, Ackerman MJ, Olson TM, Klein CJ, Thibodeau SN, Schaid DJ. PMID: 27312771.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination. Mol Immunol. 2015 Aug; 66(2):284-9. Zhang ZZ, Hsieh CL, Okitsu CY, Han L, Yu K, Lieber MR. PMID: 25899867.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids. BMC Res Notes. 2015 Apr 08; 8:127. Zhang ZZ, Pannunzio NR, Hsieh CL, Yu K, Lieber MR. PMID: 25890199.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    7. Sensitivity and specificity of immunoprecipitation of DNA containing 5-Methylcytosine. BMC Res Notes. 2015 Mar 27; 8:102. Okitsu CY, Hsieh CL. PMID: 25888776.
      View in: PubMed   Mentions: 2     Fields:    
    8. Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin. Mol Cell Biol. 2015 Apr; 35(7):1209-22. Lu Z, Lieber MR, Tsai AG, Pardo CE, Müschen M, Kladde MP, Hsieh CL. PMID: 25624348.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. The role of G-density in switch region repeats for immunoglobulin class switch recombination. Nucleic Acids Res. 2014 Dec 01; 42(21):13186-93. Zhang ZZ, Pannunzio NR, Hsieh CL, Yu K, Lieber MR. PMID: 25378327.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    10. The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites. Cell Rep. 2014 Jul 24; 8(2):557-69. Zhang ZZ, Pannunzio NR, Han L, Hsieh CL, Yu K, Lieber MR. PMID: 25017067.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    11. Reproducibility and reliability of SNP analysis using human cellular DNA at or near nanogram levels. BMC Res Notes. 2013 Dec 06; 6:515. Okitsu CY, Van Den Berg DJ, Lieber MR, Hsieh CL. PMID: 24314330.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease. Hum Genet. 2014 Mar; 133(3):347-56. Teerlink CC, Thibodeau SN, McDonnell SK, Schaid DJ, Rinckleb A, Maier C, Vogel W, Cancel-Tassin G, Egrot C, Cussenot O, Foulkes WD, Giles GG, Hopper JL, Severi G, Eeles R, Easton D, Kote-Jarai Z, Guy M, Cooney KA, Ray AM, Zuhlke KA, Lange EM, Fitzgerald LM, Stanford JL, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Isaacs WB, Wahlfors T, Tammela T, Schleutker J, Wiklund F, Grönberg H, Emanuelsson M, Carpten J, Bailey-Wilson J, Whittemore AS, Oakley-Girvan I, Hsieh CL, Catalona WJ, Zheng SL, Jin G, Lu L, Xu J, Camp NJ, Cannon-Albright LA. PMID: 24162621.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    13. Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA. Mol Cell Biol. 2013 Jul; 33(14):2683-90. Hong EE, Okitsu CY, Smith AD, Hsieh CL. PMID: 23671186.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    14. Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts. Aging Cell. 2013 Apr; 12(2):269-79. Hsieh JC, Van Den Berg D, Kang H, Hsieh CL, Lieber MR. PMID: 23425690.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    15. Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation. Mol Cell Biol. 2013 Mar; 33(5):947-57. Cui X, Lu Z, Kurosawa A, Klemm L, Bagshaw AT, Tsai AG, Gemmell N, Müschen M, Adachi N, Hsieh CL, Lieber MR. PMID: 23263985.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    16. HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet. 2013 Jan; 132(1):5-14. Xu J, Lange EM, Lu L, Zheng SL, Wang Z, Thibodeau SN, Cannon-Albright LA, Teerlink CC, Camp NJ, Johnson AM, Zuhlke KA, Stanford JL, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Maier C, Luedeke M, Vogel W, Schleutker J, Wahlfors T, Tammela T, Schaid D, McDonnell SK, DeRycke MS, Cancel-Tassin G, Cussenot O, Wiklund F, Grönberg H, Eeles R, Easton D, Kote-Jarai Z, Whittemore AS, Hsieh CL, Giles GG, Hopper JL, Severi G, Catalona WJ, Mandal D, Ledet E, Foulkes WD, Hamel N, Mahle L, Moller P, Powell I, Bailey-Wilson JE, Carpten JD, Seminara D, Cooney KA, Isaacs WB. PMID: 23064873.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    17. Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families. BMC Med Genet. 2012 Jun 19; 13:46. Bailey-Wilson JE, Childs EJ, Cropp CD, Schaid DJ, Xu J, Camp NJ, Cannon-Albright LA, Farnham JM, George A, Powell I, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Mæhle L, Møller P, Eeles R, Easton D, Guy M, Edwards S, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh CL, Dimitrov L, Stanford JL, Karyadi DM, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Thibodeau SN, McDonnell SK, Hebbring S, Lange EM, Cooney KA, Tammela TL, Schleutker J, Maier C, Bochum S, Hoegel J, Grönberg H, Wiklund F, Emanuelsson M, Cancel-Tassin G, Valeri A, Cussenot O, Isaacs WB. PMID: 22712434.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells. DNA Cell Biol. 2012 Jun; 31(6):893-907. Tsai AG, Chen DM, Lin M, Hsieh JC, Okitsu CY, Taghva A, Shibata D, Hsieh CL. PMID: 22277069.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet. 2012 Jul; 131(7):1095-103. Jin G, Lu L, Cooney KA, Ray AM, Zuhlke KA, Lange EM, Cannon-Albright LA, Camp NJ, Teerlink CC, Fitzgerald LM, Stanford JL, Wiley KE, Isaacs SD, Walsh PC, Foulkes WD, Giles GG, Hopper JL, Severi G, Eeles R, Easton D, Kote-Jarai Z, Guy M, Rinckleb A, Maier C, Vogel W, Cancel-Tassin G, Egrot C, Cussenot O, Thibodeau SN, McDonnell SK, Schaid DJ, Wiklund F, Grönberg H, Emanuelsson M, Whittemore AS, Oakley-Girvan I, Hsieh CL, Wahlfors T, Tammela T, Schleutker J, Catalona WJ, Zheng SL, Ostrander EA, Isaacs WB, Xu J. PMID: 22198737.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    20. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med. 2012 Jan; 1(1):18-28. Hasegawa K, Yasuda SY, Teo JL, Nguyen C, McMillan M, Hsieh CL, Suemori H, Nakatsuji N, Yamamoto M, Miyabayashi T, Lutzko C, Pera MF, Kahn M. PMID: 23197636.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    21. Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG. Prostate. 2012 Mar; 72(4):410-26. Lu L, Cancel-Tassin G, Valeri A, Cussenot O, Lange EM, Cooney KA, Farnham JM, Camp NJ, Cannon-Albright LA, Tammela TL, Schleutker J, Hoegel J, Herkommer K, Maier C, Vogel W, Wiklund F, Emanuelsson M, Grönberg H, Wiley KE, Isaacs SD, Walsh PC, Helfand BT, Kan D, Catalona WJ, Stanford JL, FitzGerald LM, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Whittemore AS, Oakley-Girvan I, Hsieh CL, Powell I, Bailey-Wilson JE, Cropp CD, Simpson C, Carpten JD, Seminara D, Zheng SL, Xu J, Giles GG, Severi G, Hopper JL, English DR, Foulkes WD, Maehle L, Moller P, Badzioch MD, Edwards S, Guy M, Eeles R, Easton D, Isaacs WB. PMID: 21748754.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1573-85. Zhu D, Deng X, Spee C, Sonoda S, Hsieh CL, Barron E, Pera M, Hinton DR. PMID: 21087957.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    23. Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses. Prostate. 2010 May 15; 70(7):735-44. Christensen GB, Baffoe-Bonnie AB, George A, Powell I, Bailey-Wilson JE, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Maehle L, Moller P, Eeles R, Easton D, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh CL, Dimitrov L, Xu J, Stanford JL, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Isaacs WB, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Lange EM, Cooney KA, Tammela TL, Schleutker J, Paiss T, Maier C, Grönberg H, Wiklund F, Emanuelsson M, Farnham JM, Cannon-Albright LA, Camp NJ. PMID: 20333727.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    24. Transcriptional activity affects the H3K4me3 level and distribution in the coding region. Mol Cell Biol. 2010 Jun; 30(12):2933-46. Okitsu CY, Hsieh JC, Hsieh CL. PMID: 20404096.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site. Mol Cell Biol. 2010 Jan; 30(1):146-59. Roy D, Zhang Z, Lu Z, Hsieh CL, Lieber MR. PMID: 19841062.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    26. Germline competent embryonic stem cells derived from rat blastocysts. Cell. 2008 Dec 26; 135(7):1299-310. Li P, Tong C, Mehrian-Shai R, Jia L, Wu N, Yan Y, Maxson RE, Schulze EN, Song H, Hsieh CL, Pera MF, Ying QL. PMID: 19109898.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    27. Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell. 2008 Dec 12; 135(6):1130-42. Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh CL, Lieber MR. PMID: 19070581.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    28. A simple and inexpensive on-column frit fabrication method for fused-silica capillaries for increased capacity and versatility in LC-MS/MS applications. Proteomics. 2008 May; 8(9):1758-61. Wang LC, Okitsu CY, Kochounian H, Rodriguez A, Hsieh CL, Zandi E. PMID: 18384106.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    29. Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region. Mol Cell Biol. 2007 Aug; 27(16):5921-32. Huang FT, Yu K, Balter BB, Selsing E, Oruc Z, Khamlichi AA, Hsieh CL, Lieber MR. PMID: 17562862.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    30. Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics. Hum Mol Genet. 2007 Jun 01; 16(11):1271-8. Camp NJ, Cannon-Albright LA, Farnham JM, Baffoe-Bonnie AB, George A, Powell I, Bailey-Wilson JE, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Maehle L, Moller P, Eeles R, Easton D, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh CL, Dimitrov L, Xu J, Stanford JL, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Lange EM, Cooney KA, Tammela TL, Schleutker J, Paiss T, Maier C, Grönberg H, Wiklund F, Emanuelsson M, Isaacs WB. PMID: 17478474.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    31. DNA methylation dictates histone H3K4 methylation. Mol Cell Biol. 2007 Apr; 27(7):2746-57. Okitsu CY, Hsieh CL. PMID: 17242185.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    32. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. Oncogene. 2007 May 24; 26(24):3511-20. Aoki K, Aoki M, Sugai M, Harada N, Miyoshi H, Tsukamoto T, Mizoshita T, Tatematsu M, Seno H, Chiba T, Oshima M, Hsieh CL, Taketo MM. PMID: 17160019.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    33. Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics. Hum Genet. 2006 Nov; 120(4):471-85. Schaid DJ, McDonnell SK, Zarfas KE, Cunningham JM, Hebbring S, Thibodeau SN, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Badzioch M, Bishop DT, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Guy M, Hsieh CL, Halpern J, Balise RR, Oakley-Girvan I, Whittemore AS, Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Friedrichsen DM, Deutsch K, Kolb S, Janer M, Hood L, Ostrander EA, Stanford JL, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Lange EM, Ho LA, Beebe-Dimmer JL, Wood DP, Cooney KA, Seminara D, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela TL, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Grönberg H, Camp NJ, Farnham J, Cannon-Albright LA, Catalona WJ, Suarez BK, Roehl KA. PMID: 16932970.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    34. TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways. Cytokine. 2006 Apr; 34(1-2):39-50. Higashimoto T, Panopoulos A, Hsieh CL, Zandi E. PMID: 16723255.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    35. Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5030-5. Huang FT, Yu K, Hsieh CL, Lieber MR. PMID: 16547142.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    36. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science. 2006 Jan 20; 311(5759):395-8. Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH. PMID: 16424344.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansAnimalsCells
    37. Analysis of non-B DNA structure at chromosomal sites in the mammalian genome. Methods Enzymol. 2006; 409:301-16. Raghavan SC, Tsai A, Hsieh CL, Lieber MR. PMID: 16793408.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    38. Both V(D)J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent. Mol Cell Biol. 2005 Aug; 25(15):6475-84. Raghavan SC, Hsieh CL, Lieber MR. PMID: 16024785.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    39. A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. Am J Hum Genet. 2005 Aug; 77(2):219-29. Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Bishop T, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Hsieh CL, Halpern J, Balise RN, Oakley-Girvan I, Whittemore AS, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Thibodeau SN, McDonnell SK, Cunningham JM, Zarfas KE, Hebbring S, Schaid DJ, Friedrichsen DM, Deutsch K, Kolb S, Badzioch M, Jarvik GP, Janer M, Hood L, Ostrander EA, Stanford JL, Lange EM, Beebe-Dimmer JL, Mohai CE, Cooney KA, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela TLj, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Gronberg H, Camp NJ, Farnham J, Cannon-Albright LA, Seminara D. PMID: 15988677.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    40. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J Biol Chem. 2005 Jun 17; 280(24):22749-60. Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh CL, Haworth IS, Lieber MR. PMID: 15840562.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    41. The de novo methylation activity of Dnmt3a is distinctly different than that of Dnmt1. BMC Biochem. 2005 Mar 30; 6:6. Hsieh CL. PMID: 15799776.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. Generation and characterization of endonuclease G null mice. Mol Cell Biol. 2005 Jan; 25(1):294-302. Irvine RA, Adachi N, Shibata DK, Cassell GD, Yu K, Karanjawala ZE, Hsieh CL, Lieber MR. PMID: 15601850.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    43. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell. 2004 Dec 03; 16(5):701-13. Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, Hsieh CL, Schwarz K, Lieber MR. PMID: 15574326.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    44. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. Veal N, Hsieh CL, Xiong S, Mato JM, Lu S, Tsukamoto H. PMID: 15064230.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    45. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature. 2004 Mar 04; 428(6978):88-93. Raghavan SC, Swanson PC, Wu X, Hsieh CL, Lieber MR. PMID: 14999286.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    46. Developmental retinal apoptosis in Ku86-/- mice. DNA Repair (Amst). 2003 Dec 09; 2(12):1429-34. Karanjawala ZE, Hinton DR, Oh E, Hsieh CL, Lieber MR. PMID: 14642570.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    47. Meddling with methylation. Nat Cell Biol. 2003 Jun; 5(6):502-4. Hsieh CL, Jones PA. PMID: 12776125.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    48. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol. 2003 May; 4(5):442-51. Yu K, Chedin F, Hsieh CL, Wilson TE, Lieber MR. PMID: 12679812.
      View in: PubMed   Mentions: 263     Fields:    Translation:HumansAnimalsCells
    49. Overexpression of Cu/Zn superoxide dismutase is lethal for mice lacking double-strand break repair. DNA Repair (Amst). 2003 Mar 01; 2(3):285-94. Karanjawala ZE, Hsieh CL, Lieber MR. PMID: 12547391.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    50. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16916-21. Chedin F, Lieber MR, Hsieh CL. PMID: 12481029.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    51. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst). 2002 Dec 05; 1(12):1017-26. Karanjawala ZE, Adachi N, Irvine RA, Oh EK, Shibata D, Schwarz K, Hsieh CL, Lieber MR. PMID: 12531011.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    52. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res. 2002 Nov 15; 62(22):6442-6. Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh CL, Feinberg AP. PMID: 12438232.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansCells
    53. DNA methylation has a local effect on transcription and histone acetylation. Mol Cell Biol. 2002 Oct; 22(19):6689-96. Irvine RA, Lin IG, Hsieh CL. PMID: 12215526.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    54. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002 Mar 05; 12(5):397-402. Karanjawala ZE, Murphy N, Hinton DR, Hsieh CL, Lieber MR. PMID: 11882291.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    55. Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro. Mol Cell Biol. 2002 Feb; 22(3):704-23. Lin IG, Han L, Taghva A, O'Brien LE, Hsieh CL. PMID: 11784849.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    56. A genome screen of families with multiple cases of prostate cancer: evidence of genetic heterogeneity. Am J Hum Genet. 2001 Jul; 69(1):148-58. Hsieh CL, Oakley-Girvan I, Balise RR, Halpern J, Gallagher RP, Wu AH, Kolonel LN, O'Brien LE, Lin IG, Van Den Berg DJ, Teh CZ, West DW, Whittemore AS. PMID: 11404817.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    57. Protein binding protects sites on stable episomes and in the chromosome from de novo methylation. Mol Cell Biol. 2001 May; 21(10):3416-24. Han L, Lin IG, Hsieh CL. PMID: 11313467.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    58. Chromosomal DNA demethylation specified by protein binding. EMBO Rep. 2001 Feb; 2(2):108-12. Lin IG, Hsieh CL. PMID: 11258701.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    59. Modulation of DNA binding protein affinity directly affects target site demethylation. Mol Cell Biol. 2000 Apr; 20(7):2343-9. Lin IG, Tomzynski TJ, Ou Q, Hsieh CL. PMID: 10713158.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    60. Dynamics of DNA methylation pattern. Curr Opin Genet Dev. 2000 Apr; 10(2):224-8. Hsieh CL. PMID: 10753782.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    61. The mammalian FEN-1 locus: structure and conserved sequence features. Microb Comp Genomics. 2000; 5(3):173-7. Karanjawala ZE, Shi X, Hsieh CL, Lieber MR. PMID: 11252354.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    62. In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b. Mol Cell Biol. 1999 Dec; 19(12):8211-8. Hsieh CL. PMID: 10567546.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    63. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr Biol. 1999 Dec 16-30; 9(24):1501-4. Karanjawala ZE, Grawunder U, Hsieh CL, Lieber MR. PMID: 10607596.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    64. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 1999 Nov 11; 402(6758):187-91. Xu GL, Bestor TH, Bourc'his D, Hsieh CL, Tommerup N, Bugge M, Hulten M, Qu X, Russo JJ, Viegas-Péquignot E. PMID: 10647011.
      View in: PubMed   Mentions: 293     Fields:    Translation:HumansCells
    65. No evidence of linkage for chromosome 1q42.2-43 in prostate cancer. Am J Hum Genet. 1999 Jul; 65(1):254-6. Whittemore AS, Lin IG, Oakley-Girvan I, Gallagher RP, Halpern J, Kolonel LN, Wu AH, Hsieh CL. PMID: 10364541.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    66. Evidence that protein binding specifies sites of DNA demethylation. Mol Cell Biol. 1999 Jan; 19(1):46-56. Hsieh CL. PMID: 9858530.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    67. V(D)J recombination activity in human hematopoietic cells: correlation with developmental stage and genome stability. Eur J Immunol. 1998 Jan; 28(1):351-8. Gauss GH, Domain I, Hsieh CL, Lieber MR. PMID: 9485214.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    68. Re: prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst. 1997 Dec 17; 89(24):1893-4. Hsieh CL, Oakley-Girvan I, Gallagher RP, Wu AH, Kolonel LN, Teh CZ, Halpern J, West DW, Paffenbarger RS, Whittemore AS. PMID: 9414179.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    69. Stability of patch methylation and its impact in regions of transcriptional initiation and elongation. Mol Cell Biol. 1997 Oct; 17(10):5897-904. Hsieh CL. PMID: 9315647.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    70. Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA. Nucleic Acids Res. 1996 Jun 01; 24(11):2036-43. Wu X, Li J, Li X, Hsieh CL, Burgers PM, Lieber MR. PMID: 8668533.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    71. Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human. Genomics. 1995 Jan 01; 25(1):220-5. Hiraoka LR, Harrington JJ, Gerhard DS, Lieber MR, Hsieh CL. PMID: 7774922.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    72. Dependence of transcriptional repression on CpG methylation density. Mol Cell Biol. 1994 Aug; 14(8):5487-94. Hsieh CL. PMID: 7518564.
      View in: PubMed   Mentions: 108     Fields:    Translation:Cells
    73. V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem. 1993 Sep 25; 268(27):20105-9. Hsieh CL, Arlett CF, Lieber MR. PMID: 8397200.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    74. Analysis of the defect in DNA end joining in the murine scid mutation. Mol Cell Biol. 1992 Oct; 12(10):4758-68. Harrington J, Hsieh CL, Gerton J, Bosma G, Lieber MR. PMID: 1406659.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    75. V(D)J recombination on minichromosomes is not affected by transcription. J Biol Chem. 1992 Aug 05; 267(22):15613-9. Hsieh CL, McCloskey RP, Lieber MR. PMID: 1639801.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    76. Replication, transcription, CpG methylation and DNA topology in V(D)J recombination. Curr Top Microbiol Immunol. 1992; 182:125-35. Hsieh CL, Gauss G, Lieber MR. PMID: 1490346.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    77. CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J. 1992 Jan; 11(1):315-25. Hsieh CL, Lieber MR. PMID: 1371250.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    78. V(D)J recombination: evidence that a replicative mechanism is not required. Mol Cell Biol. 1991 Aug; 11(8):3972-7. Hsieh CL, McCloskey RP, Radany E, Lieber MR. PMID: 2072902.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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