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Ian S Haworth, PhD

TitleAssociate Professor and Director of Curriculum
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressPSC 304bb
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 3310
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    Ph.D., University of Liverpool, U.K. (advisor: Prof. Raymond J. Abraham), 1986-1989, Physical Organic Chemistry. Postdoc. Oxford University, U.K. (advisor: Prof. W. Graham Richards), 1989-1992. Joined USC in 1992. Dr. Haworth's research interests lie at the interface between chemistry, biology and the computational sciences, with the goal being an improved understanding of the dynamics of molecular association of nucleic acids and proteins. Dr. Haworth has published over 60 papers in this area, and the work has attracted funding from federal and non-federal sources.

    Dr. Haworth's laboratory has developed algorithms for nucleic acid structure building, nucleic acid aptamer design, transporter protein structure and analysis, and MHC-peptide-TCR association. The basis of these algorithms is accurate reproduction of molecular association, through proper molecular and theoretical descriptions of biological interfaces.

    In the teaching area, Dr. Haworth has been active in moving part of the basic science Pharm.D. curriculum from the 'traditional' 'lecture/examination' approach to a more learner-centered, 'case study-based' approach, and has published a number of articles in this area. Dr. Haworth is a former chair of the Drug Design & Discovery section of the American Association of Pharmaceutical Scientists and is an editorial advisory board member for Pharmaceutical Research and AAPS PharmSci.


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    PEPT1: STRUCTURE-FUNCTION, SORTING AND MODULATION
    NIH/NIGMS R01GM059297Mar 1, 2000 - Feb 28, 2006
    Role: Principal Investigator
    POLYAMINES--COMPLEXES WITH ANTITUMOR MECHANISMS
    NIH/NCI R29CA064299Jul 1, 1994 - Jun 30, 2000
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Muangnoi C, Jithavech P, Ratnatilaka Na Bhuket P, Supasena W, Wichitnithad W, Towiwat P, Niwattisaiwong N, Haworth I, Rojsitthisak P. A curcumin-diglutaric acid conjugated prodrug with improved water solubility and antinociceptive properties compared to curcumin. Biosci Biotechnol Biochem. 2018 Apr 20; 1-8. PMID: 29678124.
      View in: PubMed
    2. Coricello A, El-Magboub A, Luna M, Ferrario A, Haworth I, Gomer CJ, Aiello F, Adams JD. Rational drug design and synthesis of new a-Santonin derivatives as potential COX-2 inhibitors. Bioorg Med Chem Lett. 2018 Apr 01; 28(6):993-996. PMID: 29501395.
      View in: PubMed
    3. Daga PR, Bolger MB, Haworth I, Clark RD, Martin EJ. Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability. Mol Pharm. 2018 Mar 05; 15(3):831-839. PMID: 29337562.
      View in: PubMed
    4. Daga PR, Bolger MB, Haworth I, Clark RD, Martin EJ. Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series. Mol Pharm. 2018 Mar 05; 15(3):821-830. PMID: 29337578.
      View in: PubMed
    5. Ratnatilaka Na Bhuket P, El-Magboub A, Haworth I, Rojsitthisak P. Enhancement of Curcumin Bioavailability Via the Prodrug Approach: Challenges and Prospects. Eur J Drug Metab Pharmacokinet. 2017 Jun; 42(3):341-353. PMID: 27683187.
      View in: PubMed
    6. Ambroso MR, Haworth I, Langen R. Structural Characterization of Membrane-Curving Proteins: Site-Directed Spin Labeling, EPR, and Computational Refinement. Methods Enzymol. 2015; 564:259-88. PMID: 26477254.
      View in: PubMed
    7. Beasley KN, Sutch BT, Hatmal MM, Langen R, Qin PZ, Haworth I. Computer Modeling of Spin Labels: NASNOX, PRONOX, and ALLNOX. Methods Enzymol. 2015; 563:569-93. PMID: 26478499.
      View in: PubMed
    8. Tangprasertchai NS, Zhang X, Ding Y, Tham K, Rohs R, Haworth I, Qin PZ. An Integrated Spin-Labeling/Computational-Modeling Approach for Mapping Global Structures of Nucleic Acids. Methods Enzymol. 2015; 564:427-53. PMID: 26477260; PMCID: PMC4641853.
    9. Law MJ, Lee DS, Lee CS, Anglim PP, Haworth I, Laird-Offringa IA. The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA. Nucleic Acids Res. 2013 Aug; 41(14):7092-100. PMID: 23703211; PMCID: PMC3737524.
    10. Romero RM, Rojsittisak P, Haworth I. Electrophoretic mobility of duplex DNA cross-linked by mechlorethamine at a cytosine-cytosine mismatch pair. Electrophoresis. 2013 Mar; 34(6):917-24. PMID: 23334930.
      View in: PubMed
    11. Li Y, Hatmal MM, Langen R, Haworth I. Idealized models of protofilaments of human islet amyloid polypeptide. J Chem Inf Model. 2012 Nov 26; 52(11):2983-91. PMID: 23116372; PMCID: PMC3522432.
    12. Popova AM, Hatmal MM, Frushicheva MP, Price EA, Qin PZ, Haworth I. Nitroxide sensing of a DNA microenvironment: mechanistic insights from EPR spectroscopy and molecular dynamics simulations. J Phys Chem B. 2012 Jun 07; 116(22):6387-96. PMID: 22574834; PMCID: PMC3382087.
    13. Zhang X, Tung CS, Sowa GZ, Hatmal MM, Haworth I, Qin PZ. Global structure of a three-way junction in a phi29 packaging RNA dimer determined using site-directed spin labeling. J Am Chem Soc. 2012 Feb 08; 134(5):2644-52. PMID: 22229766; PMCID: PMC3279945.
    14. Chatfield AJ, Romero RM, Haworth I. Information intervention in the pharmaceutical sciences. Med Ref Serv Q. 2012; 31(2):188-201. PMID: 22559181.
      View in: PubMed
    15. Bedrood S, Li Y, Isas JM, Hegde BG, Baxa U, Haworth I, Langen R. Fibril structure of human islet amyloid polypeptide. J Biol Chem. 2012 Feb 17; 287(8):5235-41. PMID: 22187437; PMCID: PMC3285303.
    16. Hatmal MM, Li Y, Hegde BG, Hegde PB, Jao CC, Langen R, Haworth I. Computer modeling of nitroxide spin labels on proteins. Biopolymers. 2012 Jan; 97(1):35-44. PMID: 21792846; PMCID: PMC3422567.
    17. Li Y, Sutch BT, Bui HH, Gallaher TK, Haworth I. Modeling of the water network at protein-RNA interfaces. J Chem Inf Model. 2011 Jun 27; 51(6):1347-52. PMID: 21612274.
      View in: PubMed
    18. Rojsitthisak P, Jongaroonngamsang N, Romero RM, Haworth I. HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. PLoS One. 2011; 6(6):e20745. PMID: 21673963; PMCID: PMC3108972.
    19. Xu L, Li Y, Haworth I, Davies DL. Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1. J Membr Biol. 2010 Dec; 238(1-3):43-9. PMID: 21104182; PMCID: PMC3032433.
    20. Romero RM, Eriksen SP, Haworth I. Quantitative assessment of assisted problem-based learning in a pharmaceutics course. Am J Pharm Educ. 2010 May 12; 74(4):66. PMID: 20585427; PMCID: PMC2879117.
    21. Jao CC, Hegde BG, Gallop JL, Hegde PB, McMahon HT, Haworth I, Langen R. Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation. J Biol Chem. 2010 Jun 25; 285(26):20164-70. PMID: 20418375; PMCID: PMC2888429.
    22. Sutch BT, Chambers EJ, Bayramyan MZ, Gallaher TK, Haworth I. Similarity of protein-RNA interfaces based on motif analysis. J Chem Inf Model. 2009 Sep; 49(9):2139-46. PMID: 19731952.
      View in: PubMed
    23. Xu L, Haworth I, Kulkarni AA, Bolger MB, Davies DL. Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter. Pharm Res. 2009 Oct; 26(10):2358-66. PMID: 19685173; PMCID: PMC2861424.
    24. Tsai AG, Engelhart AE, Hatmal MM, Houston SI, Hud NV, Haworth I, Lieber MR. Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. J Biol Chem. 2009 Mar 13; 284(11):7157-64. PMID: 19106104; PMCID: PMC2652318.
    25. Jao CC, Hegde BG, Chen J, Haworth I, Langen R. Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19666-71. PMID: 19066219; PMCID: PMC2605001.
    26. Li K, Xu L, Kulkarni AA, Perkins DI, Haworth I, Davies DL. Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May; 32(5):777-84. PMID: 18336632; PMCID: PMC2861421.
    27. Dowd CL, Sutch BT, Haworth I, Eritja R, Marquez VE, Yang AS. Incorporation of zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase. Nucleosides Nucleotides Nucleic Acids. 2008 Feb; 27(2):131-45. PMID: 18205068.
      View in: PubMed
    28. Bui HH, Schiewe AJ, Haworth I. WATGEN: an algorithm for modeling water networks at protein-protein interfaces. J Comput Chem. 2007 Nov 15; 28(14):2241-51. PMID: 17471455.
      View in: PubMed
    29. Price EA, Sutch BT, Cai Q, Qin PZ, Haworth I. Computation of nitroxide-nitroxide distances in spin-labeled DNA duplexes. Biopolymers. 2007 Sep; 87(1):40-50. PMID: 17538992; PMCID: PMC2430107.
    30. Cai Q, Kusnetzow AK, Hideg K, Price EA, Haworth I, Qin PZ. Nanometer distance measurements in RNA using site-directed spin labeling. Biophys J. 2007 Sep 15; 93(6):2110-7. PMID: 17526583; PMCID: PMC1959523.
    31. Schiewe AJ, Haworth I. Structure-based prediction of MHC-peptide association: algorithm comparison and application to cancer vaccine design. J Mol Graph Model. 2007 Oct; 26(3):667-75. PMID: 17493854.
      View in: PubMed
    32. Links JL, Kulkarni AA, Davies DL, Lee VH, Haworth I. Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport. J Drug Target. 2007 Apr; 15(3):218-25. PMID: 17454359.
      View in: PubMed
    33. Qin PZ, Haworth I, Cai Q, Kusnetzow AK, Grant GP, Price EA, Sowa GZ, Popova A, Herreros B, He H. Measuring nanometer distances in nucleic acids using a sequence-independent nitroxide probe. Nat Protoc. 2007; 2(10):2354-65. PMID: 17947978; PMCID: PMC2430106.
    34. Kulkarni AA, Davies DL, Links JS, Patel LN, Lee VH, Haworth I. A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of hPepT1. Pharm Res. 2007 Jan; 24(1):66-72. PMID: 17009102.
      View in: PubMed
    35. Haworth I. Computational drug delivery. Adv Drug Deliv Rev. 2006 Nov 30; 58(12-13):1271-3. PMID: 17069930.
      View in: PubMed
    36. Cai Q, Kusnetzow AK, Hubbell WL, Haworth I, Gacho GP, Van Eps N, Hideg K, Chambers EJ, Qin PZ. Site-directed spin labeling measurements of nanometer distances in nucleic acids using a sequence-independent nitroxide probe. Nucleic Acids Res. 2006; 34(17):4722-30. PMID: 16966338; PMCID: PMC1635252.
    37. Bui HH, Schiewe AJ, von Grafenstein H, Haworth I. Structural prediction of peptides binding to MHC class I molecules. Proteins. 2006 Apr 01; 63(1):43-52. PMID: 16447245.
      View in: PubMed
    38. Law MJ, Linde ME, Chambers EJ, Oubridge C, Katsamba PS, Nilsson L, Haworth I, Laird-Offringa IA. The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA. Nucleic Acids Res. 2006; 34(1):275-85. PMID: 16407334; PMCID: PMC1326249.
    39. Law MJ, Chambers EJ, Katsamba PS, Haworth I, Laird-Offringa IA. Kinetic analysis of the role of the tyrosine 13, phenylalanine 56 and glutamine 54 network in the U1A/U1 hairpin II interaction. Nucleic Acids Res. 2005; 33(9):2917-28. PMID: 15914668; PMCID: PMC1140079.
    40. Zheng Y, Haworth I, Zuo Z, Chow MS, Chow AH. Physicochemical and structural characterization of quercetin-beta-cyclodextrin complexes. J Pharm Sci. 2005 May; 94(5):1079-89. PMID: 15793810.
      View in: PubMed
    41. Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh CL, Haworth I, Lieber MR. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J Biol Chem. 2005 Jun 17; 280(24):22749-60. PMID: 15840562.
      View in: PubMed
    42. Yu K, Roy D, Bayramyan M, Haworth I, Lieber MR. Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops. Mol Cell Biol. 2005 Mar; 25(5):1730-6. PMID: 15713630; PMCID: PMC549380.
    43. Raghavan SC, Houston S, Hegde BG, Langen R, Haworth I, Lieber MR. Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region. J Biol Chem. 2004 Oct 29; 279(44):46213-25. PMID: 15328356.
      View in: PubMed
    44. Kulkarni AA, Haworth I, Uchiyama T, Lee VH. Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine-scanning mutagenesis. J Biol Chem. 2003 Dec 19; 278(51):51833-40. PMID: 14532279.
      View in: PubMed
    45. Chambers EJ, Price EA, Bayramyan MC, Haworth I. Computation of DNA backbone conformations. J Biomol Struct Dyn. 2003 Aug; 21(1):111-25. PMID: 12854963.
      View in: PubMed
    46. Kulkarni AA, Haworth I, Lee VH. Transmembrane segment 5 of the dipeptide transporter hPepT1 forms a part of the substrate translocation pathway. Biochem Biophys Res Commun. 2003 Jun 20; 306(1):177-85. PMID: 12788085.
      View in: PubMed
    47. Katsamba PS, Bayramyan M, Haworth I, Myszka DG, Laird-Offringa IA. Complex role of the beta 2-beta 3 loop in the interaction of U1A with U1 hairpin II RNA. J Biol Chem. 2002 Sep 06; 277(36):33267-74. PMID: 12082087.
      View in: PubMed
    48. Coggan DZ, Haworth I, Bates PJ, Robinson A, Rodger A. DNA Binding of Ruthenium Tris(1,10-phenanthroline): Evidence for the Dependence of Binding Mode on Metal Complex Concentration. Inorg Chem. 1999 Oct 04; 38(20):4486-4497. PMID: 11671161.
      View in: PubMed
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