Paul Seidler

Title(s)Assistant Professor of Pharmacology and Pharmaceutical Sciences
SchoolUSC School of Pharmacy
Address1985 Zonal Ave.
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 2574
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology. bioRxiv. 2025 Apr 01. Ma QL, Ebright B, Li B, Li J, Galvan J, Sanchez A, Renteln M, Dikeman D, Wang S, Kerman BE, Seidler P, Gutierrez-Grebenkova B, Hjelm BE, Hawes D, Hiniker AE, Hurth KM, Bennett DA, Louie SG, Chui HC, Limon A, Arvanitakis Z, Yassine HN. PMID: 40236242; PMCID: PMC11996316.
      View in: PubMed   Mentions:
    2. An ultra-broadband photonic-chip-based parametric amplifier. Nature. 2025 Mar; 639(8056):928-934. Kuznetsov N, Nardi A, Riemensberger J, Davydova A, Churaev M, Seidler P, Kippenberg TJ. PMID: 40074897; PMCID: PMC11946905.
      View in: PubMed   Mentions:    Fields:    
    3. Monoaminergic neurotransmitters are bimodal effectors of tau aggregation. Sci Adv. 2025 Jan 31; 11(5):eadr8055. Chang X, Tse AM, Fayzullina M, Albanese A, Kim M, Wang CF, Zheng Z, Joshi RV, Williams CK, Magaki SD, Vinters HV, Jones JO, Haworth IS, Seidler PM. PMID: 39888993; PMCID: PMC11784839.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation. PNAS Nexus. 2025 Jan; 4(1):pgaf007. Janilkarn-Urena I, Tse A, Lin J, Tafolla-Aguirre B, Idrissova A, Zhang M, Skinner SG, Mostowfi N, Kim J, Kalapatapu N, Chang X, Efthymiou C, Williams CK, Magaki SD, Vinters HV, Gonen T, Ahmed SK, Gukasyan HJ, Davies DL, Seidler PM. PMID: 39850078; PMCID: PMC11756387.
      View in: PubMed   Mentions:
    5. Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer's disease. Chem Sci. 2024 Dec 11; 15(48):20467-20477. Shyong J, Wang J, Huynh QT, Fayzullina M, Yuan B, Lee CK, Minehan T, Seidler PM, Wang CCC. PMID: 39583559; PMCID: PMC11583217.
      View in: PubMed   Mentions:
    6. Tau seeds catalyze fibril-type structures from GFP tau biosensor cells. Structure. 2024 Dec 05; 32(12):2251-2258.e3. Wang J, Williams CK, DeTure MA, Magaki SD, Dickson DW, Vinters HV, Seidler PM. PMID: 39488204.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94-Selective Ligand Binding. Proteins. 2025 Mar; 93(3):654-672. Que NLS, Seidler PM, Aw WJ, Chiosis G, Gewirth DT. PMID: 39473058; PMCID: PMC11810606.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Selective inhibition of hsp90 paralogs: Uncovering the role of helix 1 in Grp94-selective ligand binding. bioRxiv. 2024 Aug 19. Que NLS, Seidler PM, Aw WJ, Chiosis G, Gewirth DT. PMID: 37577523; PMCID: PMC10418071.
      View in: PubMed   Mentions:
    9. D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease. Sci Adv. 2024 May 03; 10(18):eadl2991. Hou K, Pan H, Shahpasand-Kroner H, Hu C, Abskharon R, Seidler P, Mekkittikul M, Balbirnie M, Lantz C, Sawaya MR, Dolinsky JL, Jones M, Zuo X, Loo JA, Frautschy S, Cole G, Eisenberg DS. PMID: 38691615; PMCID: PMC11062580.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    10. Oolonghomobisflavans from Camellia sinensis disaggregate tau fibrils across Alzheimer's disease models. bioRxiv. 2024 Mar 01. Duangjan C, Chang X, Seidler PM, Curran SP. PMID: 38464186; PMCID: PMC10925199.
      View in: PubMed   Mentions:
    11. Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2300258120. Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS. PMID: 37801475; PMCID: PMC10576031.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway. Chem Sci. 2023 Oct 18; 14(40):11022-11032. Lin SY, Oakley CE, Jenkinson CB, Chiang YM, Lee CK, Jones CG, Seidler PM, Nelson HM, Todd RB, Wang CCC, Oakley BR. PMID: 37860661; PMCID: PMC10583710.
      View in: PubMed   Mentions: 1  
    13. A heterogeneously integrated lithium niobate-on-silicon nitride photonic platform. Nat Commun. 2023 Jun 13; 14(1):3499. Churaev M, Wang RN, Riedhauser A, Snigirev V, Blésin T, Möhl C, Anderson MH, Siddharth A, Popoff Y, Drechsler U, Caimi D, Hönl S, Riemensberger J, Liu J, Seidler P, Kippenberg TJ. PMID: 37311746; PMCID: PMC10264395.
      View in: PubMed   Mentions: 16     Fields:    
    14. Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation. bioRxiv. 2023 Apr 28. Tse A, Janilkarn-Urena I, Lin J, Chang X, Efthymiou C, Idrissova A, Zhang M, Williams CK, Magaki S, Vinters HV, Davies DL, Gonen T, Gukasyan HJ, Seidler PM. PMID: 37162961; PMCID: PMC10168350.
      View in: PubMed   Mentions:
    15. Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nat Commun. 2023 04 25; 14(1):2379. Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. PMID: 37185252; PMCID: PMC10127185.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Ultrafast tunable lasers using lithium niobate integrated photonics. Nature. 2023 03; 615(7952):411-417. Snigirev V, Riedhauser A, Lihachev G, Churaev M, Riemensberger J, Wang RN, Siddharth A, Huang G, Möhl C, Popoff Y, Drechsler U, Caimi D, Hönl S, Liu J, Seidler P, Kippenberg TJ. PMID: 36922611; PMCID: PMC10017507.
      View in: PubMed   Mentions: 22     Fields:    
    17. Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proc Natl Acad Sci U S A. 2023 02 14; 120(7):e2217835120. Murray KA, Hu CJ, Pan H, Lu J, Abskharon R, Bowler JT, Rosenberg GM, Williams CK, Elezi G, Balbirnie M, Faull KF, Vinters HV, Seidler PM, Eisenberg DS. PMID: 36757890; PMCID: PMC9963379.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    18. Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun. 2022 09 16; 13(1):5451. Seidler PM, Murray KA, Boyer DR, Ge P, Sawaya MR, Hu CJ, Cheng X, Abskharon R, Pan H, DeTure MA, Williams CK, Dickson DW, Vinters HV, Eisenberg DS. PMID: 36114178; PMCID: PMC9481533.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    19. De novo designed protein inhibitors of amyloid aggregation and seeding. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2206240119. Murray KA, Hu CJ, Griner SL, Pan H, Bowler JT, Abskharon R, Rosenberg GM, Cheng X, Seidler PM, Eisenberg DS. PMID: 35969734; PMCID: PMC9407671.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    20. Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nat Struct Mol Biol. 2022 06; 29(6):529-536. Murray KA, Hughes MP, Hu CJ, Sawaya MR, Salwinski L, Pan H, French SW, Seidler PM, Eisenberg DS. PMID: 35637421; PMCID: PMC9205782.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    21. Microwave-to-optical conversion with a gallium phosphide photonic crystal cavity. Nat Commun. 2022 Apr 19; 13(1):2065. Hönl S, Popoff Y, Caimi D, Beccari A, Kippenberg TJ, Seidler P. PMID: 35440549; PMCID: PMC9019098.
      View in: PubMed   Mentions: 10     Fields:    
    22. Three-repeat and four-repeat tau isoforms form different oligomers. Protein Sci. 2022 03; 31(3):613-627. Shahpasand-Kroner H, Portillo J, Lantz C, Seidler PM, Sarafian N, Loo JA, Bitan G. PMID: 34902187; PMCID: PMC8862439.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    23. Maximizing Completion of the Two-Dose COVID-19 Vaccine Series with Aid from Infographics. Vaccines (Basel). 2021 Oct 22; 9(11). Crutcher M, Seidler PM. PMID: 34835158; PMCID: PMC8618920.
      View in: PubMed   Mentions: 3  
    24. Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimers Res Ther. 2021 Apr 19; 13(1):83. Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. PMID: 33879220; PMCID: PMC8056581.
      View in: PubMed   Mentions:    Fields:    
    25. Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv. 2021 Mar 18. Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS. PMID: 33688654; PMCID: PMC7941625.
      View in: PubMed   Mentions: 2  
    26. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J Biol Chem. 2020 07 31; 295(31):10662-10676. Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS. PMID: 32493775; PMCID: PMC7397112.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    27. Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimers Res Ther. 2019 10 18; 11(1):86. Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. PMID: 31627745; PMCID: PMC6800506.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    28. Structure-based inhibitors of amyloid beta core suggest a common interface with tau. Elife. 2019 10 15; 8. Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. PMID: 31612856; PMCID: PMC6850776.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    29. Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J Biol Chem. 2019 11 01; 294(44):16451-16464. Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS. PMID: 31537646; PMCID: PMC6827308.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    30. Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 02 23; 293(8):2888-2902. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. PMID: 29282295; PMCID: PMC5827424.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    31. Structure-based inhibitors of tau aggregation. Nat Chem. 2018 02; 10(2):170-176. Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS. PMID: 29359764; PMCID: PMC5784779.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    32. Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat Methods. 2017 Feb 13; 14(4):399-402. de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T. PMID: 28192420; PMCID: PMC5376236.
      View in: PubMed   Mentions: 91     Fields:    Translation:Cells
    33. Characterization of the Grp94/OS-9 chaperone-lectin complex. J Mol Biol. 2014 Oct 23; 426(21):3590-605. Seidler PM, Shinsky SA, Hong F, Li Z, Cosgrove MS, Gewirth DT. PMID: 25193139; PMCID: PMC4188734.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    34. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Nov; 9(11):677-84. Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. PMID: 23995768; PMCID: PMC3982621.
      View in: PubMed   Mentions: 111     Fields:    Translation:Humans
    35. Investigations of chemical modifications of amino-terminated organic films on silicon substrates and controlled protein immobilization. Langmuir. 2010 Feb 16; 26(4):2599-608. Kim J, Cho J, Seidler PM, Kurland NE, Yadavalli VK. PMID: 20095550.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    36. Formation, structure, and reactivity of amino-terminated organic films on silicon substrates. J Colloid Interface Sci. 2009 Jan 01; 329(1):114-9. Kim J, Seidler P, Wan LS, Fill C. PMID: 18930465.
      View in: PubMed   Mentions: 26     Fields:    
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