Clay C. C. Wang, PhD

TitleProfessor of Pharmacology & Pharmaceutical Sciences and Department Chair
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressPSC 402
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 1670
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wu R, Murali R, Kabe Y, French SW, Chiang YM, Liu S, Sher L, Wang C, Louie S, Tsukamoto H. Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition. Hepatology. 2018 May 05. PMID: 29729190.
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    2. Kaur K, Wu X, Fields JK, Johnson DK, Lan L, Pratt M, Somoza AD, Wang C, Karanicolas J, Oakley BR, Xu L, De Guzman RN. The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro. PLoS One. 2017; 12(4):e0175471. PMID: 28414767.
      View in: PubMed
    3. Sung CT, Chang SL, Entwistle R, Ahn G, Lin TS, Petrova V, Yeh HH, Praseuth MB, Chiang YM, Oakley BR, Wang C. Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan. Fungal Genet Biol. 2017 04; 101:1-6. PMID: 28108400.
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    4. van Dijk JW, Guo CJ, Wang C. Engineering Fungal Nonribosomal Peptide Synthetase-like Enzymes by Heterologous Expression and Domain Swapping. Org Lett. 2016 Dec 16; 18(24):6236-6239. PMID: 27978657.
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    5. Oakley CE, Ahuja M, Sun WW, Entwistle R, Akashi T, Yaegashi J, Guo CJ, Cerqueira GC, Russo Wortman J, Wang C, Chiang YM, Oakley BR. Discovery of McrA, a master regulator of Aspergillus secondary metabolism. Mol Microbiol. 2017 Jan; 103(2):347-365. PMID: 27775185.
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    6. Knox BP, Blachowicz A, Palmer JM, Romsdahl J, Huttenlocher A, Wang C, Keller NP, Venkateswaran K. Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station. mSphere. 2016 Sep-Oct; 1(5). PMID: 27830189.
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    7. Yeh HH, Ahuja M, Chiang YM, Oakley CE, Moore S, Yoon O, Hajovsky H, Bok JW, Keller NP, Wang C, Oakley BR. Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor. ACS Chem Biol. 2016 08 19; 11(8):2275-84. PMID: 27294372.
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    8. Lin TS, Chiang YM, Wang C. Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans. Org Lett. 2016 Mar 18; 18(6):1366-9. PMID: 26954888.
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    9. Barkal LJ, Theberge AB, Guo CJ, Spraker J, Rappert L, Berthier J, Brakke KA, Wang C, Beebe DJ, Keller NP, Berthier E. Microbial metabolomics in open microscale platforms. Nat Commun. 2016 Feb 04; 7:10610. PMID: 26842393.
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    10. Sun WW, Guo CJ, Wang C. Characterization of the product of a nonribosomal peptide synthetase-like (NRPS-like) gene using the doxycycline dependent Tet-on system in Aspergillus terreus. Fungal Genet Biol. 2016 Apr; 89:84-88. PMID: 26851300.
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    11. Chiang YM, Ahuja M, Oakley CE, Entwistle R, Asokan A, Zutz C, Wang C, Oakley BR. Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin. Angew Chem Int Ed Engl. 2016 Jan 26; 55(5):1662-5. PMID: 26563584; PMCID: PMC4724294 [Available on 01/01/17].
    12. Guo CJ, Sun WW, Bruno KS, Oakley BR, Keller NP, Wang C. Spatial regulation of a common precursor from two distinct genes generates metabolite diversity. Chem Sci. 2015 Oct 01; 6(10):5913-5921. PMID: 28791090.
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    13. Paranjape SR, Riley AP, Somoza AD, Oakley CE, Wang C, Prisinzano TE, Oakley BR, Gamblin TC. Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro. ACS Chem Neurosci. 2015 May 20; 6(5):751-60. PMID: 25822288.
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    14. Gao YQ, Guo CJ, Zhang Q, Zhou WM, Wang C, Gao JM. Asperaculanes A and B, two sesquiterpenoids from the fungus Aspergillus aculeatus. Molecules. 2014 Dec 25; 20(1):325-34. PMID: 25547729.
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    15. Guo CJ, Wang C. Recent advances in genome mining of secondary metabolites in Aspergillus terreus. Front Microbiol. 2014; 5:717. PMID: 25566227; PMCID: PMC4274970.
    16. Guo CJ, Sun WW, Bruno KS, Wang C. Molecular genetic characterization of terreic acid pathway in Aspergillus terreus. Org Lett. 2014 Oct 17; 16(20):5250-3. PMID: 25265334; PMCID: PMC4201328.
    17. Ishikawa N, Tanaka H, Koyama F, Noguchi H, Wang C, Hotta K, Watanabe K. Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids. Angew Chem Int Ed Engl. 2014 Nov 17; 53(47):12880-4. PMID: 25251934.
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    18. Lee KH, Ho WY, Wu SJ, Cheng TL, Huang PJ, Wang C, Hung JH. Behavior-selective apoptotic capacity of 4-(3,4,5-Trimethoxyphenoxy) benzoic acid and its methyl derivatives on two breast cancer cell lines. Anticancer Res. 2014 Apr; 34(4):1801-9. PMID: 24692713.
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    19. Liu T, Sanchez JF, Chiang YM, Oakley BR, Wang C. Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases. Org Lett. 2014 Mar 21; 16(6):1676-9. PMID: 24593241; PMCID: PMC3993715.
    20. Paranjape SR, Chiang YM, Sanchez JF, Entwistle R, Wang C, Oakley BR, Gamblin TC. Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,?-dihydroxyemodin, asperthecin, and asperbenzaldehyde. Planta Med. 2014 Jan; 80(1):77-85. PMID: 24414310.
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    21. Lee KH, Ho WY, Wu SJ, Omar HA, Huang PJ, Wang C, Hung JH. Modulation of cyclins, p53 and mitogen-activated protein kinases signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. Int J Mol Sci. 2014 Jan 08; 15(1):743-57. PMID: 24406729; PMCID: PMC3907835.
    22. Yaegashi J, Oakley BR, Wang C. Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans. J Ind Microbiol Biotechnol. 2014 Feb; 41(2):433-42. PMID: 24342965; PMCID: PMC4324552.
    23. Wiemann P, Guo CJ, Palmer JM, Sekonyela R, Wang C, Keller NP. Prototype of an intertwined secondary-metabolite supercluster. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17065-70. PMID: 24082142; PMCID: PMC3801025.
    24. Bok JW, Soukup AA, Chadwick E, Chiang YM, Wang C, Keller NP. VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation. Mol Microbiol. 2013 Sep; 89(5):963-74. PMID: 23841751; PMCID: PMC3773851.
    25. Guo CJ, Knox BP, Sanchez JF, Chiang YM, Bruno KS, Wang C. Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus. Org Lett. 2013 Jul 19; 15(14):3562-5. PMID: 23841722; PMCID: PMC3833251.
    26. Yaegashi J, Praseuth MB, Tyan SW, Sanchez JF, Entwistle R, Chiang YM, Oakley BR, Wang C. Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans. Org Lett. 2013 Jun 07; 15(11):2862-5. PMID: 23706169; PMCID: PMC3713076.
    27. Chiang YM, Oakley CE, Ahuja M, Entwistle R, Schultz A, Chang SL, Sung CT, Wang C, Oakley BR. An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans. J Am Chem Soc. 2013 May 22; 135(20):7720-31. PMID: 23621425; PMCID: PMC3697937.
    28. Guo CJ, Yeh HH, Chiang YM, Sanchez JF, Chang SL, Bruno KS, Wang C. Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis. J Am Chem Soc. 2013 May 15; 135(19):7205-13. PMID: 23586797; PMCID: PMC3695726.
    29. Berthier E, Lim FY, Deng Q, Guo CJ, Kontoyiannis DP, Wang C, Rindy J, Beebe DJ, Huttenlocher A, Keller NP. Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS Pathog. 2013; 9(4):e1003289. PMID: 23592999; PMCID: PMC3623715.
    30. Chang SL, Chiang YM, Yeh HH, Wu TK, Wang C. Reconstitution of the early steps of gliotoxin biosynthesis in Aspergillus nidulans reveals the role of the monooxygenase GliC. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2155-7. PMID: 23434416; PMCID: PMC3640825.
    31. Yeh HH, Chang SL, Chiang YM, Bruno KS, Oakley BR, Wu TK, Wang C. Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping. Org Lett. 2013 Feb 15; 15(4):756-9. PMID: 23368695; PMCID: PMC3681297.
    32. Lee KH, Wu CJ, Wang C, Hung JH. Prevention of chronic HBV infection induced hepatocellular carcinoma development by using antiplatelet drugs. Hepatobiliary Surg Nutr. 2012 Dec; 1(1):57-8. PMID: 24570904; PMCID: PMC3924632.
    33. Yin WB, Reinke AW, Szilágyi M, Emri T, Chiang YM, Keating AE, Pócsi I, Wang C, Keller NP. bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology. 2013 Jan; 159(Pt 1):77-88. PMID: 23154967; PMCID: PMC3542729.
    34. Guo CJ, Knox BP, Chiang YM, Lo HC, Sanchez JF, Lee KH, Oakley BR, Bruno KS, Wang C. Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Org Lett. 2012 Nov 16; 14(22):5684-7. PMID: 23116177; PMCID: PMC3538129.
    35. Soukup AA, Chiang YM, Bok JW, Reyes-Dominguez Y, Oakley BR, Wang C, Strauss J, Keller NP. Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production. Mol Microbiol. 2012 Oct; 86(2):314-30. PMID: 22882998; PMCID: PMC3514908.
    36. Sanchez JF, Entwistle R, Corcoran D, Oakley BR, Wang C. Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans. Medchemcomm. 2012 Aug 01; 3(8). PMID: 24244835.
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    37. Lin WC, Chuang YC, Chang YS, Lai MD, Teng YN, Su IJ, Wang C, Lee KH, Hung JH. Endoplasmic reticulum stress stimulates p53 expression through NF-?B activation. PLoS One. 2012; 7(7):e39120. PMID: 22859938; PMCID: PMC3408479.
    38. Yeh HH, Chiang YM, Entwistle R, Ahuja M, Lee KH, Bruno KS, Wu TK, Oakley BR, Wang C. Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis. Appl Microbiol Biotechnol. 2012 Nov; 96(3):739-48. PMID: 22627757; PMCID: PMC3713075.
    39. Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang C. Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans. J Am Chem Soc. 2012 May 16; 134(19):8212-21. PMID: 22510154; PMCID: PMC3357392.
    40. Yang MD, Chiang YM, Higashiyama R, Asahina K, Mann DA, Mann J, Wang C, Tsukamoto H. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor ? in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81. PMID: 22095555; PMCID: PMC3302956.
    41. Lo HC, Entwistle R, Guo CJ, Ahuja M, Szewczyk E, Hung JH, Chiang YM, Oakley BR, Wang C. Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans. J Am Chem Soc. 2012 Mar 14; 134(10):4709-20. PMID: 22329759; PMCID: PMC3350773.
    42. Yin WB, Amaike S, Wohlbach DJ, Gasch AP, Chiang YM, Wang C, Bok JW, Rohlfs M, Keller NP. An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR. Mol Microbiol. 2012 Mar; 83(5):1024-34. PMID: 22283524; PMCID: PMC3288630.
    43. Somoza AD, Lee KH, Chiang YM, Oakley BR, Wang C. Reengineering an azaphilone biosynthesis pathway in Aspergillus nidulans to create lipoxygenase inhibitors. Org Lett. 2012 Feb 17; 14(4):972-5. PMID: 22296232; PMCID: PMC3350772.
    44. Sanchez JF, Somoza AD, Keller NP, Wang C. Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep. 2012 Mar; 29(3):351-71. PMID: 22228366; PMCID: PMC4568942.
    45. Lim FY, Sanchez JF, Wang C, Keller NP. Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi. Methods Enzymol. 2012; 517:303-24. PMID: 23084945; PMCID: PMC3703436.
    46. Sanchez JF, Wang C. The chemical identification and analysis of Aspergillus nidulans secondary metabolites. Methods Mol Biol. 2012; 944:97-109. PMID: 23065610; PMCID: PMC3754429.
    47. Hung JH, Teng YN, Wang LH, Su IJ, Wang C, Huang W, Lee KH, Lu KY, Wang LH. Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells. PLoS One. 2011; 6(12):e28977. PMID: 22216150; PMCID: PMC3245229.
    48. Liu T, Chiang YM, Somoza AD, Oakley BR, Wang C. Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans. J Am Chem Soc. 2011 Aug 31; 133(34):13314-6. PMID: 21815681; PMCID: PMC3350771.
    49. Giles SS, Soukup AA, Lauer C, Shaaban M, Lin A, Oakley BR, Wang C, Keller NP. Cryptic Aspergillus nidulans antimicrobials. Appl Environ Microbiol. 2011 Jun; 77(11):3669-75. PMID: 21478304; PMCID: PMC3127626.
    50. Sanchez JF, Entwistle R, Hung JH, Yaegashi J, Jain S, Chiang YM, Wang C, Oakley BR. Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans. J Am Chem Soc. 2011 Mar 23; 133(11):4010-7. PMID: 21351751; PMCID: PMC3119361.
    51. Chiang YM, Meyer KM, Praseuth M, Baker SE, Bruno KS, Wang C. Characterization of a polyketide synthase in Aspergillus niger whose product is a precursor for both dihydroxynaphthalene (DHN) melanin and naphtho-?-pyrone. Fungal Genet Biol. 2011 Apr; 48(4):430-7. PMID: 21176790; PMCID: PMC3118676.
    52. Chiang YM, Chang SL, Oakley BR, Wang C. Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr Opin Chem Biol. 2011 Feb; 15(1):137-43. PMID: 21111669; PMCID: PMC3117463.
    53. Palmer JM, Mallaredy S, Perry DW, Sanchez JF, Theisen JM, Szewczyk E, Oakley BR, Wang C, Keller NP, Mirabito PM. Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans. Microbiology. 2010 Dec; 156(Pt 12):3522-31. PMID: 20724388; PMCID: PMC3068700.
    54. Chiang YM, Oakley BR, Keller NP, Wang C. Unraveling polyketide synthesis in members of the genus Aspergillus. Appl Microbiol Biotechnol. 2010 May; 86(6):1719-36. PMID: 20361326; PMCID: PMC3110678.
    55. Wang C, Chiang YM, Praseuth MB, Kuo PL, Liang HL, Hsu YL. Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis. Basic Clin Pharmacol Toxicol. 2010 Jul; 107(1):583-9. PMID: 20148857; PMCID: PMC3110816.
    56. Chiang YM, Szewczyk E, Davidson AD, Entwistle R, Keller NP, Wang C, Oakley BR. Characterization of the Aspergillus nidulans monodictyphenone gene cluster. Appl Environ Microbiol. 2010 Apr; 76(7):2067-74. PMID: 20139316; PMCID: PMC2849234.
    57. Sanchez JF, Chiang YM, Szewczyk E, Davidson AD, Ahuja M, Elizabeth Oakley C, Woo Bok J, Keller N, Oakley BR, Wang C. Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans. Mol Biosyst. 2010 Mar; 6(3):587-93. PMID: 20174687; PMCID: PMC2903553.
    58. Chiang YM, Lee KH, Sanchez JF, Keller NP, Wang C. Unlocking fungal cryptic natural products. Nat Prod Commun. 2009 Nov; 4(11):1505-10. PMID: 19967983; PMCID: PMC3101174.
    59. Watanabe K, Hotta K, Praseuth AP, Searcey M, Wang C, Oguri H, Oikawa H. Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. Chembiochem. 2009 Aug 17; 10(12):1965-8. PMID: 19588480; PMCID: PMC4556348.
    60. Watanabe K, Hotta K, Nakaya M, Praseuth AP, Wang C, Inada D, Takahashi K, Fukushi E, Oguri H, Oikawa H. Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. J Am Chem Soc. 2009 Jul 08; 131(26):9347-53. PMID: 19514719; PMCID: PMC2757413.
    61. Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang C, Keller NP. Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol. 2009 Jul; 5(7):462-4. PMID: 19448638; PMCID: PMC2891026.
    62. Li AY, Boo LM, Wang SY, Lin HH, Wang C, Yen Y, Chen BP, Chen DJ, Ann DK. Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res. 2009 Jul 15; 69(14):5699-706. PMID: 19549901; PMCID: PMC2737594.
    63. Chiang YM, Szewczyk E, Davidson AD, Keller N, Oakley BR, Wang C. A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. J Am Chem Soc. 2009 Mar 04; 131(8):2965-70. PMID: 19199437; PMCID: PMC2765542.
    64. Praseuth AP, Wang C, Watanabe K, Hotta K, Oguri H, Oikawa H. Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnol Prog. 2008 Nov-Dec; 24(6):1226-31. PMID: 19194935.
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    65. Szewczyk E, Chiang YM, Oakley CE, Davidson AD, Wang C, Oakley BR. Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans. Appl Environ Microbiol. 2008 Dec; 74(24):7607-12. PMID: 18978088; PMCID: PMC2607171.
    66. Wang C, Chiang YM, Kuo PL, Chang JK, Hsu YL. Norsolorinic acid inhibits proliferation of T24 human bladder cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas/membrane-bound Fas ligand-mediated apoptotic pathway. Clin Exp Pharmacol Physiol. 2008 Nov; 35(11):1301-8. PMID: 18671724.
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    67. Chiang YM, Szewczyk E, Nayak T, Davidson AD, Sanchez JF, Lo HC, Ho WY, Simityan H, Kuo E, Praseuth A, Watanabe K, Oakley BR, Wang C. Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chem Biol. 2008 Jun; 15(6):527-32. PMID: 18559263; PMCID: PMC2494592.
    68. Wang C, Chiang YM, Kuo PL, Chang JK, Hsu YL. Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway. Basic Clin Pharmacol Toxicol. 2008 Jun; 102(6):491-7. PMID: 18346044; PMCID: PMC3754440.
    69. Sanchez JF, Chiang YM, Wang C. Diversity of polyketide synthases found in the Aspergillus and Streptomyces genomes. Mol Pharm. 2008 Mar-Apr; 5(2):226-33. PMID: 18338869.
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    70. Praseuth AP, Praseuth MB, Oguri H, Oikawa H, Watanabe K, Wang C. Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture. Biotechnol Prog. 2008 Jan-Feb; 24(1):134-9. PMID: 18173279.
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    71. Wang C, Chiang YM, Sung SC, Hsu YL, Chang JK, Kuo PL. Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells. Cancer Lett. 2008 Jan 18; 259(1):82-98. PMID: 18023967.
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    72. Ma SM, Zhan J, Watanabe K, Xie X, Zhang W, Wang C, Tang Y. Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc. 2007 Sep 05; 129(35):10642-3. PMID: 17696354; PMCID: PMC2528842.
    73. Marques MA, Citron DM, Wang C. Development of Tyrocidine A analogues with improved antibacterial activity. Bioorg Med Chem. 2007 Nov 01; 15(21):6667-77. PMID: 17728134; PMCID: PMC2706120.
    74. Zhang W, Watanabe K, Wang C, Tang Y. Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway. J Biol Chem. 2007 Aug 31; 282(35):25717-25. PMID: 17631493.
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    75. Watanabe K, Praseuth AP, Wang C. A comprehensive and engaging overview of the type III family of polyketide synthases. Curr Opin Chem Biol. 2007 Jun; 11(3):279-86. PMID: 17482864.
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    76. Zhang W, Watanabe K, Wang C, Tang Y. Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase. J Nat Prod. 2006 Nov; 69(11):1633-6. PMID: 17125237.
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    77. Xie X, Watanabe K, Wojcicki WA, Wang C, Tang Y. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem Biol. 2006 Nov; 13(11):1161-9. PMID: 17113998.
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    78. Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang C, Oguri H, Oikawa H. Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nat Chem Biol. 2006 Aug; 2(8):423-8. PMID: 16799553.
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    79. Pfeifer BA, Wang C, Walsh CT, Khosla C. Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl Environ Microbiol. 2003 Nov; 69(11):6698-702. PMID: 14602630; PMCID: PMC262314.
    80. Watanabe K, Wang C, Boddy CN, Cane DE, Khosla C. Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. J Biol Chem. 2003 Oct 24; 278(43):42020-6. PMID: 12923197.
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