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    Sean P. Curran, PhD

    TitleAssociate Professor
    SchoolSchool of Gerontology
    AddressGER 342
    University Park Campus
    Los Angeles California 90089-0191
    Phone+1 213 740 5354
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      The Curran lab seeks to understand the molecules, genes and cells that impact aging and age related diseases. Aging is a universal and inevitable process driven by diverse molecular pathways and surprisingly remains a fundamental mystery of biology. Among the genes that most potently influence the rate of aging in C. elegans are those that are essential for growth and development. More than 90% of these genes have conserved developmental roles from yeast to man and together may represent an evolutionarily conserved program to modulate lifespan. Many of these genes function independently of the canonical longevity-modulating pathways such as insulin/IGF-I signaling, dietary restriction, mitochondrial respiration and reproduction. Inactivation of one group of longevity modulators results in somatic cells with germ cell-like characteristics and increased lifespan. The idea that somatic cells maintain the potential to reacquire pathways lost during differentiation is tantalizing and suggests a mechanism for increasing lifespan through enhanced cellular repair and possibly regeneration. Since C. elegans longevity mutants are resistant to many age-related conditions and disease models, a better characterization of these pathways will provide a means to uncover new therapeutic strategies for the treatment of age-related pathologies in humans and provide insight into essential cellular pathways that regulate aging and development.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Pradhan A, Hammerquist AM, Khanna A, Curran S. The C-box region of MAF1 regulates transcriptional activity and protein stability. J Mol Biol. 2016 Dec 13. PMID: 27986570.
        View in: PubMed
      2. Yen CA, Curran S. Gene-diet interactions and aging in C. elegans. Exp Gerontol. 2016 Dec 15; 86:106-112. PMID: 26924670.
        View in: PubMed
      3. Lynn DA, Dalton HM, Sowa JN, Wang MC, Soukas AA, Curran S. Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15378-83. PMID: 26621724; PMCID: PMC4687584.
      4. Lynn DA, Curran S. The SKN-1 hunger games: May the odds be ever in your favor. Worm. 2015 Jul-Sep; 4(3):e1078959. PMID: 26430571; PMCID: PMC4588153.
      5. Khanna A, Pradhan A, Curran S. Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity. J Mol Biol. 2015 Aug 14; 427(16):2577-85. PMID: 26173035; PMCID: PMC4523411.
      6. Khanna A, Johnson DL, Curran S. Physiological roles for mafr-1 in reproduction and lipid homeostasis. Cell Rep. 2014 Dec 24; 9(6):2180-91. PMID: 25497095; PMCID: PMC4391630.
      7. Pang S, Lynn DA, Lo JY, Paek J, Curran S. SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation. Nat Commun. 2014 Oct 06; 5:5048. PMID: 25284427; PMCID: PMC4205844.
      8. Pang S, Curran S. Adaptive capacity to bacterial diet modulates aging in C. elegans. Cell Metab. 2014 Feb 04; 19(2):221-31. PMID: 24440036; PMCID: PMC3979424.
      9. Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran S. Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One. 2012; 7(10):e48282. PMID: 23144747; PMCID: PMC3483217.
      10. Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran S. Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab. 2012 Oct 03; 16(4):526-37. PMID: 23040073; PMCID: PMC3774140.
      11. Pang S, Curran S. Longevity and the long arm of epigenetics: acquired parental marks influence lifespan across several generations. Bioessays. 2012 Aug; 34(8):652-4. PMID: 22674543; PMCID: PMC3779125.
      12. Curran S, Wu X, Riedel CG, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009 Jun 25; 459(7250):1079-84. PMID: 19506556; PMCID: PMC2716045.
      13. Curran S, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007 Apr 06; 3(4):e56. PMID: 17411345; PMCID: PMC1847696.
      14. Likic VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, Keeling PJ, Koehler CM, Curran S, Gooley PR, Lithgow T. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. J Mol Biol. 2005 Mar 18; 347(1):81-93. PMID: 15733919.
        View in: PubMed
      15. Curran S, Leverich EP, Koehler CM, Larsen PL. Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development. J Biol Chem. 2004 Dec 24; 279(52):54655-62. PMID: 15485840.
        View in: PubMed
      16. Curran S, Leuenberger D, Leverich EP, Hwang DK, Beverly KN, Koehler CM. The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. J Biol Chem. 2004 Oct 15; 279(42):43744-51. PMID: 15294910.
        View in: PubMed
      17. Leuenberger D, Curran S, Wong D, Koehler CM. The role of Tim9p in the assembly of the TIM22 import complexes. Traffic. 2003 Mar; 4(3):144-52. PMID: 12656987.
        View in: PubMed
      18. Curran S, Leuenberger D, Schmidt E, Koehler CM. The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol. 2002 Sep 16; 158(6):1017-27. PMID: 12221072; PMCID: PMC2173223.
      19. Curran S, Leuenberger D, Oppliger W, Koehler CM. The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier. EMBO J. 2002 Mar 01; 21(5):942-53. PMID: 11867522; PMCID: PMC125908.
      20. Roesch K, Curran S, Tranebjaerg L, Koehler CM. Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. Hum Mol Genet. 2002 Mar 01; 11(5):477-86. PMID: 11875042.
        View in: PubMed
      21. Murphy MP, Leuenberger D, Curran S, Oppliger W, Koehler CM. The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex. Mol Cell Biol. 2001 Sep; 21(18):6132-8. PMID: 11509656; PMCID: PMC87330.