Sean P. Curran, PhD

Title(s)Professor of Gerontology, Vice Dean, Dean of Faculty and Research, James E. Birren Chair in Gerontology
SchoolSchool of Gerontology
AddressGER 112A
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 5354
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    Collapse Overview 
    Collapse Overview
    The Curran lab seeks to understand the molecules, genes and cells that impact aging and age related diseases. Aging is a universal and inevitable process driven by diverse molecular pathways and surprisingly remains a fundamental mystery of biology. Among the genes that most potently influence the rate of aging in C. elegans are those that are essential for growth and development. More than 90% of these genes have conserved developmental roles from yeast to man and together may represent an evolutionarily conserved program to modulate lifespan. Many of these genes function independently of the canonical longevity-modulating pathways such as insulin/IGF-I signaling, dietary restriction, mitochondrial respiration and reproduction. Inactivation of one group of longevity modulators results in somatic cells with germ cell-like characteristics and increased lifespan. The idea that somatic cells maintain the potential to reacquire pathways lost during differentiation is tantalizing and suggests a mechanism for increasing lifespan through enhanced cellular repair and possibly regeneration. Since C. elegans longevity mutants are resistant to many age-related conditions and disease models, a better characterization of these pathways will provide a means to uncover new therapeutic strategies for the treatment of age-related pathologies in humans and provide insight into essential cellular pathways that regulate aging and development.

    Collapse Research 
    Collapse Research Activities and Funding
    The University of Southern California and Buck Institute Nathan Shock Center
    NIH P30AG068345Sep 15, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Characterizing WDR23 in Alzheimer's disease pathology
    NIH/NIA R01AG063947Aug 15, 2019 - May 31, 2024
    Role: Principal Investigator
    Age-dependent SKN-1/NRF cytoprotection at the cost of metabolic homeostasis
    NIH R01AG058610Aug 15, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Characterizing WDR23 in Alzheimer's disease pathology
    NIH RF1AG063947Aug 15, 2019 - Mar 31, 2024
    Role: Principal Investigator
    Convergent approaches to lifespan health
    NIH K07AG060268May 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Novel roles for Maf1 as a central regulator of lipid homeostasis
    NIH R01GM109028Sep 1, 2014 - Aug 31, 2020
    Role: Principal Investigator
    Evolutionarily conserved mechanisms of lifespan regulation
    NIH R00AG032308Apr 15, 2011 - Mar 31, 2014
    Role: Principal Investigator
    Evolutionarily conserved mechanisms of lifespan regulation
    NIH K99AG032308Aug 15, 2009 - Jul 31, 2011
    Role: Principal Investigator
    Neuronal outputs regulated by insulin signaling
    NIH F32AG026207Apr 1, 2005 - Mar 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus. Mech Ageing Dev. 2024 Feb 01; 218:111914. Liu J, Duangjan C, Irwin RW, Curran SP. PMID: 38301772.
      View in: PubMed   Mentions:    Fields:    
    2. Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain. Cell Signal. 2024 Jan 17; 116:111061. Duangjan C, Irwin RW, Curran SP. PMID: 38242270.
      View in: PubMed   Mentions:    Fields:    
    3. A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons. Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52):e2308565120. Turner CD, Stuhr NL, Ramos CM, Van Camp BT, Curran SP. PMID: 38113255.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus. bioRxiv. 2023 Oct 11. Liu J, Duangjan C, Irwin RW, Curran SP. PMID: 37873429; PMCID: PMC10592735.
      View in: PubMed   Mentions: 1  
    5. A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons. bioRxiv. 2023 Oct 02. Turner CD, Stuhr NL, Ramos CM, Van Camp BT, Curran SP. PMID: 37873147; PMCID: PMC10592859.
      View in: PubMed   Mentions:
    6. Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation. Geroscience. 2023 Dec; 45(6):3359-3370. Ramos CM, Curran SP. PMID: 37751046; PMCID: PMC10643742.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Different methods of killing bacteria diets differentially influence Caenorhabditis elegans physiology. MicroPubl Biol. 2023; 2023. Stuhr NL, Curran SP. PMID: 37746065; PMCID: PMC10514698.
      View in: PubMed   Mentions: 1  
    8. Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans. Elife. 2023 08 22; 12. Cedillo L, Ahsan FM, Li S, Stuhr NL, Zhou Y, Zhang Y, Adedoja A, Murphy LM, Yerevanian A, Emans S, Dao K, Li Z, Peterson ND, Watrous J, Jain M, Das S, Pukkila-Worley R, Curran SP, Soukas AA. PMID: 37606250; PMCID: PMC10444025.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    9. Riboflavin depletion promotes longevity and metabolic hormesis in Caenorhabditis elegans. Aging Cell. 2022 11; 21(11):e13718. Yerevanian A, Murphy LM, Emans S, Zhou Y, Ahsan FM, Baker D, Li S, Adedoja A, Cedillo L, Stuhr NL, Gnanatheepam E, Dao K, Jain M, Curran SP, Georgakoudi I, Soukas AA. PMID: 36181246; PMCID: PMC9649603.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    10. Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species. Elife. 2022 04 26; 11. Villa O, Stuhr NL, Yen CA, Crimmins EM, Arpawong TE, Curran SP. PMID: 35470798; PMCID: PMC9106327.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. Rapid Lipid Quantification in Caenorhabditis elegans by Oil Red O and Nile Red Staining. Bio Protoc. 2022 Mar 05; 12(5):e4340. Stuhr NL, Nhan JD, Hammerquist AM, Van Camp B, Reoyo D, Curran SP. PMID: 35592599; PMCID: PMC8918222.
      View in: PubMed   Mentions: 8  
    12. Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects. Geroscience. 2022 02; 44(1):463-483. Raffaele M, Kovacovicova K, Biagini T, Lo Re O, Frohlich J, Giallongo S, Nhan JD, Giannone AG, Cabibi D, Ivanov M, Tonchev AB, Mistrik M, Lacey M, Dzubak P, Gurska S, Hajduch M, Bartek J, Mazza T, Micale V, Curran SP, Vinciguerra M. PMID: 34820764; PMCID: PMC8612119.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    13. Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan. Geroscience. 2022 02; 44(1):533-545. Duangjan C, Curran SP. PMID: 34637108; PMCID: PMC8811050.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    14. University of Southern California and buck institute nathan shock center: multidimensional models of aging. Geroscience. 2021 10; 43(5):2119-2127. Curran SP, Lithgow GJ, Verdin E, P C. PMID: 34269983; PMCID: PMC8599784.
      View in: PubMed   Mentions:    Fields:    
    15. Analysis of Caenorhabditis elegans Sperm Number, Size, Activation, and Mitochondrial Content. Bio Protoc. 2021 Jun 05; 11(11):e4035. Hammerquist AM, Yen CA, Curran SP. PMID: 34250202; PMCID: PMC8250386.
      View in: PubMed   Mentions:
    16. Maf1 regulates intracellular lipid homeostasis in response to DNA damage response activation. Mol Biol Cell. 2021 05 15; 32(11):1086-1093. Hammerquist AM, Escorcia W, Curran SP. PMID: 33788576; PMCID: PMC8351542.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    17. Incomplete proline catabolism drives premature sperm aging. Aging Cell. 2021 02; 20(2):e13308. Yen CA, Curran SP. PMID: 33480139; PMCID: PMC7884046.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female Drosophila melanogaster. J Gerontol A Biol Sci Med Sci. 2021 01 18; 76(2):195-204. Landis GN, Doherty DV, Yen CA, Wang L, Fan Y, Wang I, Vroegop J, Wang T, Wu J, Patel P, Lee S, Abdelmesieh M, Shen J, Promislow DEL, Curran SP, Tower J. PMID: 32648907; PMCID: PMC7812429.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans. Sci Rep. 2020 11 09; 10(1):19367. Hammerquist AM, Curran SP. PMID: 33168938; PMCID: PMC7652826.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans. Commun Biol. 2020 11 06; 3(1):653. Stuhr NL, Curran SP. PMID: 33159120; PMCID: PMC7648844.
      View in: PubMed   Mentions: 33  Translation:AnimalsCells
    21. Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans. Elife. 2020 02 05; 9. Yen CA, Ruter DL, Turner CD, Pang S, Curran SP. PMID: 32022684; PMCID: PMC7032928.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    22. Methods for Assessing Fertility in C. elegans from a Single Population. Methods Mol Biol. 2020; 2144:91-102. Yen CA, Curran SP. PMID: 32410027.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. Metabolic Assessment of Lipid Abundance and Distribution. Methods Mol Biol. 2020; 2144:103-110. Nhan JD, Curran SP. PMID: 32410028.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection. Proc Natl Acad Sci U S A. 2019 10 29; 116(44):22322-22330. Nhan JD, Turner CD, Anderson SM, Yen CA, Dalton HM, Cheesman HK, Ruter DL, Uma Naresh N, Haynes CM, Soukas AA, Pukkila-Worley R, Curran SP. PMID: 31611372; PMCID: PMC6825279.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    25. Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates. Sci Rep. 2019 08 13; 9(1):11783. Spatola BN, Lo JY, Wang B, Curran SP. PMID: 31409866; PMCID: PMC6692315.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    26. Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter. J Gerontol A Biol Sci Med Sci. 2019 07 12; 74(8):1189-1197. Haghani A, Dalton HM, Safi N, Shirmohammadi F, Sioutas C, Morgan TE, Finch CE, Curran SP. PMID: 30828708; PMCID: PMC6625599.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    27. Hypodermal responses to protein synthesis inhibition induce systemic developmental arrest and AMPK-dependent survival in Caenorhabditis elegans. PLoS Genet. 2018 07; 14(7):e1007520. Dalton HM, Curran SP. PMID: 30020921; PMCID: PMC6066256.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    28. Quantification of Lipid Abundance and Evaluation of Lipid Distribution in Caenorhabditis elegans by Nile Red and Oil Red O Staining. J Vis Exp. 2018 03 05; (133). Escorcia W, Ruter DL, Nhan J, Curran SP. PMID: 29553519; PMCID: PMC5931440.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    29. Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival. Cell Rep. 2017 07 18; 20(3):627-640. Webster CM, Pino EC, Carr CE, Wu L, Zhou B, Cedillo L, Kacergis MC, Curran SP, Soukas AA. PMID: 28723566; PMCID: PMC5578715.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. WDR23 regulates NRF2 independently of KEAP1. PLoS Genet. 2017 04; 13(4):e1006762. Lo JY, Spatola BN, Curran SP. PMID: 28453520; PMCID: PMC5428976.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    31. The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. J Mol Biol. 2017 01 20; 429(2):192-207. Pradhan A, Hammerquist AM, Khanna A, Curran SP. PMID: 27986570; PMCID: PMC5480515.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Gene-diet interactions and aging in C. elegans. Exp Gerontol. 2016 12 15; 86:106-112. Yen CA, Curran SP. PMID: 26924670; PMCID: PMC5001925.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15378-83. Lynn DA, Dalton HM, Sowa JN, Wang MC, Soukas AA, Curran SP. PMID: 26621724; PMCID: PMC4687584.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    34. The SKN-1 hunger games: May the odds be ever in your favor. Worm. 2015 Jul-Sep; 4(3):e1078959. Lynn DA, Curran SP. PMID: 26430571; PMCID: PMC4588153.
      View in: PubMed   Mentions: 4  
    35. Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity. J Mol Biol. 2015 Aug 14; 427(16):2577-85. Khanna A, Pradhan A, Curran SP. PMID: 26173035; PMCID: PMC4523411.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    36. Physiological roles for mafr-1 in reproduction and lipid homeostasis. Cell Rep. 2014 Dec 24; 9(6):2180-91. Khanna A, Johnson DL, Curran SP. PMID: 25497095; PMCID: PMC4391630.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    37. SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation. Nat Commun. 2014 Oct 06; 5:5048. Pang S, Lynn DA, Lo JY, Paek J, Curran SP. PMID: 25284427; PMCID: PMC4205844.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    38. Adaptive capacity to bacterial diet modulates aging in C. elegans. Cell Metab. 2014 Feb 04; 19(2):221-31. Pang S, Curran SP. PMID: 24440036; PMCID: PMC3979424.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    39. Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One. 2012; 7(10):e48282. Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP. PMID: 23144747; PMCID: PMC3483217.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    40. Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab. 2012 Oct 03; 16(4):526-37. Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP. PMID: 23040073; PMCID: PMC3774140.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    41. Longevity and the long arm of epigenetics: acquired parental marks influence lifespan across several generations. Bioessays. 2012 Aug; 34(8):652-4. Pang S, Curran SP. PMID: 22674543; PMCID: PMC3779125.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    42. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009 Jun 25; 459(7250):1079-84. Curran SP, Wu X, Riedel CG, Ruvkun G. PMID: 19506556; PMCID: PMC2716045.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    43. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007 Apr 06; 3(4):e56. Curran SP, Ruvkun G. PMID: 17411345; PMCID: PMC1847696.
      View in: PubMed   Mentions: 260     Fields:    Translation:AnimalsCells
    44. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. J Mol Biol. 2005 Mar 18; 347(1):81-93. Likic VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, Keeling PJ, Koehler CM, Curran SP, Gooley PR, Lithgow T. PMID: 15733919.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    45. Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development. J Biol Chem. 2004 Dec 24; 279(52):54655-62. Curran SP, Leverich EP, Koehler CM, Larsen PL. PMID: 15485840.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    46. The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. J Biol Chem. 2004 Oct 15; 279(42):43744-51. Curran SP, Leuenberger D, Leverich EP, Hwang DK, Beverly KN, Koehler CM. PMID: 15294910.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    47. The role of Tim9p in the assembly of the TIM22 import complexes. Traffic. 2003 Mar; 4(3):144-52. Leuenberger D, Curran SP, Wong D, Koehler CM. PMID: 12656987.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    48. The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol. 2002 Sep 16; 158(6):1017-27. Curran SP, Leuenberger D, Schmidt E, Koehler CM. PMID: 12221072; PMCID: PMC2173223.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    49. Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. Hum Mol Genet. 2002 Mar 01; 11(5):477-86. Roesch K, Curran SP, Tranebjaerg L, Koehler CM. PMID: 11875042.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    50. The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier. EMBO J. 2002 Mar 01; 21(5):942-53. Curran SP, Leuenberger D, Oppliger W, Koehler CM. PMID: 11867522; PMCID: PMC125908.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
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