Ryo Sanabria

Title(s)Assistant Professor of Gerontology
SchoolSchool of Gerontology
Address3715 Mcclintock Ave.
University Park Campus
Los Angeles CA 90089
Phone+1 213 821 8554
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    More than just a load control: cytoskeletal form and function during aging
    NIH R00AG065200May 1, 2020 - May 31, 2024
    Role: Principal Investigator
    More than just a load control: cytoskeletal form and function during aging
    NIH K99AG065200May 1, 2020 - Apr 30, 2022
    Role: Principal Investigator
    The Cytoskeletal Stress Response: A Novel Facet to Protecting Cell Integrity during Aging
    NIH F32AG053023Jul 1, 2016 - Jun 30, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Further Probing the Properties of a Unique Sponge-derived Alkaloid Through the Isolation of a New (-)-(5E)-(8R)-(14Z)-Mycothiazole Analogue. J Nat Prod. 2024 Oct 25; 87(10):2523-2529. Gerke JA, Odron SF, Kim J, Dutta N, Clarke JG, Media J, Coppage DA, Oorloff M, Alcala A, Garcia G, Kang MEF, Gerke CL, Peterson JC, Morris JD, Higuchi-Sanabria R, Valeriote FA, Crews P, Johnson TA. PMID: 39348562; PMCID: PMC11534373.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Growth on stiffer substrates impacts animal health and longevity in C. elegans. PLoS One. 2024; 19(9):e0302673. Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Minor C, Castro Torres T, Moaddeli D, Vega M, Kim J, Bong A, Coakley AJ, Hicks D, Wang J, Wang T, Hoang S, Tharp KM, Garcia G, Higuchi-Sanabria R. PMID: 39264947; PMCID: PMC11392421.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. The extracellular matrix integrates mitochondrial homeostasis. Cell. 2024 Aug 08; 187(16):4289-4304.e26. Zhang H, Tsui CK, Garcia G, Joe LK, Wu H, Maruichi A, Fan W, Pandovski S, Yoon PH, Webster BM, Durieux J, Frankino PA, Higuchi-Sanabria R, Dillin A. PMID: 38942015.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice. bioRxiv. 2024 Jun 13. Thorwald M, Godoy-Lugo JA, Garcia G, Silva J, Kim M, Christensen A, Mack WJ, Head E, O'Day PA, Benayoun BA, Morgan TE, Pike CJ, Higuchi-Sanabria R, Forman HJ, Finch CE. PMID: 37034750; PMCID: PMC10081222.
      View in: PubMed   Mentions:
    5. Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons. bioRxiv. 2024 May 30. Coakley AJ, Hruby A, Wang J, Bong A, Nair T, Ramos CM, Alcala A, Averbukh M, Dutta N, Moaddeli D, Hicks D, de Los Rios Rogers M, Sahay A, Curran SP, Mullen PJ, Benayoun BA, Garcia G, Higuchi-Sanabria R. PMID: 38854121; PMCID: PMC11160609.
      View in: PubMed   Mentions:
    6. A metabolic atlas of mouse aging. bioRxiv. 2024 May 05. Pilley SE, Awad D, Latumalea D, Esparza E, Zhang L, Shi X, Unfried M, Wang S, Mulondo R, Kashyap SB, Moaddeli D, Sajjakulnukit P, Sutton D, Wong H, Coakley AJ, Garcia G, Higuchi-Sanabria R, Liu S, Yu B, Tu WB, Kennedy BK, Lyssiotis CA, Mullen PJ. PMID: 38746230; PMCID: PMC11092783.
      View in: PubMed   Mentions:
    7. Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans. bioRxiv. 2024 Apr 12. Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Torres TC, Moaddeli D, Vega M, Kim J, Bong A, Coakley AJ, Hicks D, Wang J, Wang T, Hoang S, Tharp KM, Garcia G, Higuchi-Sanabria R. PMID: 38645203; PMCID: PMC11030433.
      View in: PubMed   Mentions:
    8. Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Dec; 46(6):6009-6028. Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Kim J, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. PMID: 38570396; PMCID: PMC11493899.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging. bioRxiv. 2023 Nov 27. Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Castro Torres T, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. PMID: 38077060; PMCID: PMC10705228.
      View in: PubMed   Mentions:
    10. Glial-derived mitochondrial signals affect neuronal proteostasis and aging. Sci Adv. 2023 10 13; 9(41):eadi1411. Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. PMID: 37831769; PMCID: PMC10575585.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Glial-derived mitochondrial signals impact neuronal proteostasis and aging. bioRxiv. 2023 Aug 08. Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. PMID: 37609253; PMCID: PMC10441375.
      View in: PubMed   Mentions:
    12. Lipid homeostasis is essential for a maximal ER stress response. Elife. 2023 07 25; 12. Garcia G, Zhang H, Moreno S, Tsui CK, Webster BM, Higuchi-Sanabria R, Dillin A. PMID: 37489956; PMCID: PMC10368420.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. More than a loading control: actin regulation in aging. Aging (Albany NY). 2023 05 18; 15(10):3896-3898. Averbukh M, Garcia G, Higuchi-Sanabria R. PMID: 37204421; PMCID: PMC10258002.
      View in: PubMed   Mentions:    Fields:    
    14. A tale of two pathways: Regulation of proteostasis by UPRmt and MDPs. Curr Opin Neurobiol. 2023 02; 78:102673. Johns A, Higuchi-Sanabria R, Thorwald MA, Vilchez D. PMID: 36621224; PMCID: PMC9845188.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    15. Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span. Aging Cell. 2023 01; 22(1):e13742. Garcia G, Bar-Ziv R, Averbukh M, Dasgupta N, Dutta N, Zhang H, Fan W, Moaddeli D, Tsui CK, Castro Torres T, Alcala A, Moehle EA, Hoang S, Shalem O, Adams PD, Thorwald MA, Higuchi-Sanabria R. PMID: 36404134; PMCID: PMC9835578.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. SKN-1 regulates stress resistance downstream of amino catabolism pathways. iScience. 2022 Jul 15; 25(7):104571. Frankino PA, Siddiqi TF, Bolas T, Bar-Ziv R, Gildea HK, Zhang H, Higuchi-Sanabria R, Dillin A. PMID: 35784796; PMCID: PMC9240870.
      View in: PubMed   Mentions: 7  
    17. Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans. J Vis Exp. 2022 05 18; (183). Castro Torres T, Moaddeli D, Averbukh M, Coakley AJ, Dutta N, Garcia G, Higuchi-Sanabria R. PMID: 35665741; PMCID: PMC9881476.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    18. Identification of a modulator of the actin cytoskeleton, mitochondria, nutrient metabolism and lifespan in yeast. Nat Commun. 2022 05 16; 13(1):2706. Sing CN, Garcia EJ, Lipkin TG, Huckaba TM, Tsang CA, Coughlin AC, Yang EJ, Boldogh IR, Higuchi-Sanabria R, Pon LA. PMID: 35577788; PMCID: PMC9110415.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Hijacking Cellular Stress Responses to Promote Lifespan. Front Aging. 2022; 3:860404. Dutta N, Garcia G, Higuchi-Sanabria R. PMID: 35821861; PMCID: PMC9261414.
      View in: PubMed   Mentions: 16  
    20. A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan. Neural Regen Res. 2022 Feb; 17(2):309-310. Homentcovschi S, Higuchi-Sanabria R. PMID: 34269195; PMCID: PMC8463978.
      View in: PubMed   Mentions: 2  
    21. Imaging the Actin Cytoskeleton in Live Budding Yeast Cells. Methods Mol Biol. 2022; 2364:53-80. Sing CN, Yang EJ, Swayne TC, Higuchi-Sanabria R, Tsang CA, Boldogh IR, Pon LA. PMID: 34542848; PMCID: PMC11060504.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Imaging the Actin Cytoskeleton in Fixed Budding Yeast Cells. Methods Mol Biol. 2022; 2364:81-100. Sing CN, Yang EJ, Higuchi-Sanabria R, Pon LA, Boldogh IR, Swayne TC. PMID: 34542849; PMCID: PMC10131176.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. Imaging of Actin Cytoskeletal Integrity During Aging in C. elegans. Methods Mol Biol. 2022; 2364:101-137. Garcia G, Homentcovschi S, Kelet N, Higuchi-Sanabria R. PMID: 34542850.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization. Sci Adv. 2021 Oct 29; 7(44):eabj6818. Moehle EA, Higuchi-Sanabria R, Tsui CK, Homentcovschi S, Tharp KM, Zhang H, Chi H, Joe L, de Los Rios Rogers M, Sahay A, Kelet N, Benitez C, Bar-Ziv R, Garcia G, Shen K, Frankino PA, Schinzel RT, Shalem O, Dillin A. PMID: 34714674; PMCID: PMC8555897.
      View in: PubMed   Mentions: 5     Fields:    
    25. Measuring expression heterogeneity of single-cell cytoskeletal protein complexes. Nat Commun. 2021 08 17; 12(1):4969. Vlassakis J, Hansen LL, Higuchi-Sanabria R, Zhou Y, Tsui CK, Dillin A, Huang H, Herr AE. PMID: 34404787; PMCID: PMC8371148.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Adhesion-mediated mechanosignaling forces mitohormesis. Cell Metab. 2021 07 06; 33(7):1322-1341.e13. Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM. PMID: 34019840; PMCID: PMC8266765.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    27. Divergent Nodes of Non-autonomous UPRER Signaling through Serotonergic and Dopaminergic Neurons. Cell Rep. 2020 12 08; 33(10):108489. Higuchi-Sanabria R, Durieux J, Kelet N, Homentcovschi S, de Los Rios Rogers M, Monshietehadi S, Garcia G, Dallarda S, Daniele JR, Ramachandran V, Sahay A, Tronnes SU, Joe L, Dillin A. PMID: 33296657; PMCID: PMC8820220.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    28. Beyond the cell factory: Homeostatic regulation of and by the UPRER. Sci Adv. 2020 07; 6(29):eabb9614. Metcalf MG, Higuchi-Sanabria R, Garcia G, Tsui CK, Dillin A. PMID: 32832649; PMCID: PMC7439504.
      View in: PubMed   Mentions: 53     Fields:    
    29. Lysosomal recycling of amino acids affects ER quality control. Sci Adv. 2020 06; 6(26):eaaz9805. Higuchi-Sanabria R, Shen K, Kelet N, Frankino PA, Durieux J, Bar-Ziv R, Sing CN, Garcia EJ, Homentcovschi S, Sanchez M, Wu R, Tronnes SU, Joe L, Webster B, Ahilon-Jeronimo A, Monshietehadi S, Dallarda S, Pender C, Pon LA, Zoncu R, Dillin A. PMID: 32637599; PMCID: PMC7319768.
      View in: PubMed   Mentions: 13     Fields:    
    30. Measurements of Physiological Stress Responses in C. Elegans. J Vis Exp. 2020 05 21; (159). Bar-Ziv R, Frakes AE, Higuchi-Sanabria R, Bolas T, Frankino PA, Gildea HK, Metcalf MG, Dillin A. PMID: 32510480; PMCID: PMC7840273.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. UPRER promotes lipophagy independent of chaperones to extend life span. Sci Adv. 2020 01; 6(1):eaaz1441. Daniele JR, Higuchi-Sanabria R, Durieux J, Monshietehadi S, Ramachandran V, Tronnes SU, Kelet N, Sanchez M, Metcalf MG, Garcia G, Frankino PA, Benitez C, Zeng M, Esping DJ, Joe L, Dillin A. PMID: 31911951; PMCID: PMC6938708.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    32. Live-cell imaging of mitochondrial motility and interactions in Drosophila neurons and yeast. Methods Cell Biol. 2020; 155:519-544. Liao PC, Higuchi-Sanabria R, Swayne TC, Sing CN, Pon LA. PMID: 32183975.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    33. The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. Cell. 2019 11 27; 179(6):1306-1318.e18. Schinzel RT, Higuchi-Sanabria R, Shalem O, Moehle EA, Webster BM, Joe L, Bar-Ziv R, Frankino PA, Durieux J, Pender C, Kelet N, Kumar SS, Savalia N, Chi H, Simic M, Nguyen NT, Dillin A. PMID: 31761535; PMCID: PMC6913896.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    34. Reciprocal interactions between mtDNA and lifespan control in budding yeast. Mol Biol Cell. 2019 11 15; 30(24):2943-2952. Garcia EJ, de Jonge JJ, Liao PC, Stivison E, Sing CN, Higuchi-Sanabria R, Boldogh IR, Pon LA. PMID: 31599702; PMCID: PMC6857569.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    35. X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation. Dev Cell. 2019 10 21; 51(2):192-207.e6. Anderson EC, Frankino PA, Higuchi-Sanabria R, Yang Q, Bian Q, Podshivalova K, Shin A, Kenyon C, Dillin A, Meyer BJ. PMID: 31495695; PMCID: PMC6810858.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    36. Spatial regulation of the actin cytoskeleton by HSF-1 during aging. Mol Biol Cell. 2018 10 15; 29(21):2522-2527. Higuchi-Sanabria R, Paul JW 3rd, Durieux J, Benitez C, Frankino PA, Tronnes SU, Garcia G, Daniele JR, Monshietehadi S, Dillin A. PMID: 30133343; PMCID: PMC6254583.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    37. A Futile Battle? Protein Quality Control and the Stress of Aging. Dev Cell. 2018 Jan 22; 44(2):139-163. Higuchi-Sanabria R, Frankino PA, Paul JW, Tronnes SU, Dillin A. PMID: 29401418; PMCID: PMC5896312.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    38. The transcriptional repressor Sum1p counteracts Sir2p in regulation of the actin cytoskeleton, mitochondrial quality control and replicative lifespan in Saccharomyces cerevisiae. Microb Cell. 2016 Jan 18; 3(2):79-88. Higuchi-Sanabria R, Vevea JD, Charalel JK, Sapar ML, Pon LA. PMID: 28357337; PMCID: PMC5349106.
      View in: PubMed   Mentions: 5  
    39. Mitochondrial anchorage and fusion contribute to mitochondrial inheritance and quality control in the budding yeast Saccharomyces cerevisiae. Mol Biol Cell. 2016 Mar 01; 27(5):776-87. Higuchi-Sanabria R, Charalel JK, Viana MP, Garcia EJ, Sing CN, Koenigsberg A, Swayne TC, Vevea JD, Boldogh IR, Rafelski SM, Pon LA. PMID: 26764088; PMCID: PMC4803304.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    40. Characterization of Fluorescent Proteins for Three- and Four-Color Live-Cell Imaging in S. cerevisiae. PLoS One. 2016; 11(1):e0146120. Higuchi-Sanabria R, Garcia EJ, Tomoiaga D, Munteanu EL, Feinstein P, Pon LA. PMID: 26727004; PMCID: PMC4699809.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. Imaging of the Actin Cytoskeleton and Mitochondria in Fixed Budding Yeast Cells. Methods Mol Biol. 2016; 1365:63-81. Higuchi-Sanabria R, Swayne TC, Boldogh IR, Pon LA. PMID: 26498779.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    42. Live-Cell Imaging of Mitochondria and the Actin Cytoskeleton in Budding Yeast. Methods Mol Biol. 2016; 1365:25-62. Higuchi-Sanabria R, Swayne TC, Boldogh IR, Pon LA. PMID: 26498778; PMCID: PMC8522908.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    43. Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae. FEMS Yeast Res. 2014 Dec; 14(8):1133-46. Higuchi-Sanabria R, Pernice WM, Vevea JD, Alessi Wolken DM, Boldogh IR, Pon LA. PMID: 25263578; PMCID: PMC4270926.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
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