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Berenice A. Benayoun

Photo of Berenice A. Benayoun
Title(s)Associate Professor of Gerontology and Cancer Biology
SchoolSchool of Gerontology
AddressGER B14
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 6394
ORCID ORCID Icon0000-0002-7401-4777 Additional info
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    Collapse Biography 
    Collapse education and training
    Universite Paris Diderot-Paris 7, Paris, FrancePhD2/2011Genetics, reproduction
    Stanford University, Palo Alto, CApostdoc7/2017Aging biology
    ENS/Universite Paris Diderot-Paris 7, Paris, FranceMSc7/2007Genetics
    ENS/Universite Paris Diderot-Paris 7, Paris, FranceBSc7/2005Genetics, Cell Biology
    Collapse awards and honors
    2023AGHE Rising Star Early Career Faculty Award
    2023USC Mentoring Award recipients for Faculty Mentoring Undergraduate Students
    2023Rising Star in Reproductive Biology (awarded by the Society for the Study of Reproduction)
    2021Nathan Shock New Investigator award (awarded by the Gerontology Society of America)
    2019Rosalind Franklin Young Investigator Award in Mammalian Genetics

    Collapse Overview 
    Collapse overview
    Bérénice Benayoun, Ph.D., is an Assistant Professor of Gerontology and Biological Sciences at USC Leonard Davis School of Gerontology. She holds secondary appointments in the Department of Molecular and Computational Biology Department of the USC Dornsife College of Letters, Arts and Sciences and the USC Norris Comprehensive Cancer Center. She joined the USC faculty in 2017.

    Dr. Benayoun received her undergraduate and graduate degrees at the École Normale Supérieure de Paris and Université Paris Diderot-Paris 7 in Paris, France. Her PhD work focused on a transcription factor whose mutations lead to a human syndrome associated to premature menopause. During her post-doctoral training, she identified a new key chromatin signature of cell identity and transcriptional consistency, which is partially remodeled during aging. This work has raised important questions about the stability of cellular identity throughout life. Her lab’s current research focuses on epigenome and transcriptome remodeling with aging in vertebrates, how these changes interact with overlooked cues such as biological sex, and the roles that these changes can play in the aging process. Her lab is also one of the pioneering labs in the development of a naturally short-lived vertebrate as a new model for aging research, the African turquoise killifish Nothobranchius furzeri.

    Dr. Benayoun was named a 2020 Pew Biomedical Scholar and the 2021 Nathan Shock new Investigator. Since starting as faculty, she has also been the recipient of the 2019 Rosalind Franklin Young Investigator Award in Mammalian Genetics, of a Junior Faculty Award from the American Federation of Aging Research, of Junior Scholar Award from the Global Consortium for Reproductive Longevity and Equality GCRLE. She also serves on the editorial boards of scientific journals Translational Medicine of Aging, Journals of Gerontology series A: Biological Sciences and eLife.
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    Collapse Research 
    Collapse research activities and funding
    Single-cell exploration of ovarian aging across vertebrates
    CZI 2023-323351May 1, 2023 - Sep 30, 2024
    Role: PI
    Deciphering hormonal regulation of neutrophil biology
    NIH R01AG076433Sep 30, 2022 - May 31, 2026
    Role: Principal Investigator
    Understanding the regulation and impact of transposable elements in Vertebrate health and disease
    NIH R35GM142395Aug 20, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Simons Collaboration on Plasticity in the Aging Brain
    Simons Foundation SF811217Oct 1, 2020 - Sep 30, 2025
    Transposable elements as drivers of normal and accelerated aging in Vertebrates
    NIH R21AG063739Aug 1, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Regulation of transcriptional consistency by broad H3K4me3 domains in young cells and during aging
    NIH R00AG049934Apr 15, 2015 - May 31, 2021
    Role: Principal Investigator
    Regulation of transcriptional consistency by broad H3K4me3 domains in young cells and during aging
    NIH K99AG049934Apr 15, 2015 - Jul 14, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Estropausal gut microbiota transplant improves measures of ovarian function in adult mice. Nat Aging. 2026 Mar 03. Kim M, Wang J, Pilley SE, Lu RJ, Xu A, Kim Y, Liu M, Fu X, Booth SL, Mullen PJ, Benayoun BA. PMID: 41776310.
      View in: PubMed   Mentions:
    2. The interplay of epigenetic remodelling and transposon-mediated genomic instability in ageing and longevity. Open Biol. 2026 Jan 28; 16(1). Lemus AJJ, Tewelde E, Bhala R, Guan A, Xu A, Benayoun BA. PMID: 41592738.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Past, present and future perspectives on the science of aging. Nat Aging. 2026 Jan; 6(1):6-22. Ambrosio F, Artyomov MN, Austad SN, Barzilai N, Belmonte JCI, Belsky DW, Benayoun BA, Brunet A, Dönertas HM, Dubal DB, Fang EF, Feige JN, Fried LP, Furman D, Gao X, Gladyshev VN, Gorbunova V, Gorospe M, Han JJ, Hansson O, Hara E, Horvath S, Ip NY, Kuchel GA, Kaeberlein M, Lamming DW, Levy BR, Liu GH, Lee J, Moffitt TE, Minamino T, Partridge L, Raina P, Rando TA, Rowe JW, Schwartz M, Scott AJ, Sierra F, Sinclair DA, Teunissen CE, Vellas B, Verdin E, Walker KA, Webb AE, Wyss-Coray T, Xu M, Yu JT, Zhavoronkov A, Aman Y, Kriebs A, Ren Q, Walters H, Thuault S. PMID: 41566049.
      View in: PubMed   Mentions:
    4. The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain. Cell Rep. 2026 Jan 27; 45(1):116729. Higginson LA, Wang X, He K, Torstrick M, Kim M, Wijeratne HRS, Runnebohm AM, Benayoun BA, MacLean A, Chanfreau GF, Morton DJ. PMID: 41417727; PMCID: PMC12952294.
      View in: PubMed   Mentions:
    5. A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways. Geroscience. 2025 Dec 11. Bravo JI, Tewelde E, King CD, Bons J, Shah S, Rose J, Campisi J, Schilling B, Benayoun BA. PMID: 41381971.
      View in: PubMed   Mentions:
    6. Studying ovarian aging and its health impacts: modern tools and approaches. Genes Dev. 2025 Aug 01; 39(15-16):975-990. Benayoun BA, Kochersberger A, Garrison JL. PMID: 40639912; PMCID: PMC12315883.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    7. Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice. Commun Med (Lond). 2025 Jun 10; 5(1):222. McGill CJ, Christensen A, Qian W, Thorwald MA, Lugo JG, Namvari S, White OS, Finch CE, Benayoun BA, Pike CJ. PMID: 40494894; PMCID: PMC12152157.
      View in: PubMed   Mentions: 2  
    8. Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. Alzheimers Dement. 2025 Jun; 21(6):e70322. Thorwald MA, Godoy-Lugo JA, Kerstiens E, Garcia G, Kim M, Shemtov SJ, Silva J, Durra S, O'Day PA, Mack WJ, Hiniker A, Vermulst M, Benayoun BA, Higuchi-Sanabria R, Forman HJ, Head E, Finch CE. PMID: 40536124; PMCID: PMC12177674.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Sex-dimorphic gene regulation in murine macrophages across niches. Immunol Cell Biol. 2025 Jul; 103(6):563-577. McGill CJ, White OS, Lu RJ, Sampathkumar NK, Benayoun BA. PMID: 40390161; PMCID: PMC12247447.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Aging activates escape of the silent X chromosome in the female mouse hippocampus. Sci Adv. 2025 Mar 07; 11(10):eads8169. Gadek M, Shaw CK, Abdulai-Saiku S, Saloner R, Marino F, Wang D, Bonham LW, Yokoyama JS, Panning B, Benayoun BA, Casaletto KB, Ramani V, Dubal DB. PMID: 40043106; PMCID: PMC11881916.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Strategies for studying sex differences in brain aging. Trends Genet. 2025 Aug; 41(8):678-690. Ansere VA, Kim SS, Marino F, Morillo K, Dubal DB, Murphy CT, Suh Y, Benayoun BA. PMID: 40037936; PMCID: PMC12324943.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers. Transl Med Aging. 2025; 9:25-40. Bravo JI, Zhang L, Benayoun BA. PMID: 40051556; PMCID: PMC11883834.
      View in: PubMed   Mentions:
    13. A researcher's guide to studying sex differences in immune aging. Trends Mol Med. 2025 Aug; 31(8):702-717. Baker C, Kim M, Benayoun BA. PMID: 39884873; PMCID: PMC12304246.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    14. Biological sex matters in brain aging. Neuron. 2025 Jan 08; 113(1):2-6. Dubal DB, Murphy CT, Suh Y, Benayoun BA. PMID: 39788086; PMCID: PMC12210274.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    15. Iron-associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice. Alzheimers Dement. 2025 Jan; 21(1):e14541. Thorwald MA, Godoy-Lugo JA, Garcia G, Silva J, Kim M, Christensen A, Mack WJ, Head E, O'Day PA, Benayoun BA, Morgan TE, Pike CJ, Higuchi-Sanabria R, Forman HJ, Finch CE. PMID: 39876821; PMCID: PMC11775463.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression. Cancer Res. 2024 Oct 01; 84(19):3141-3157. Iriondo O, Mecenas D, Li Y, Chin CR, Thomas A, Moriarty A, Marker R, Wang YJ, Hendrick H, Amzaleg Y, Ortiz V, MacKay M, Dickerson A, Lee G, Harotoonian S, Benayoun BA, Smith A, Mason CE, Roussos Torres ET, Klotz R, Yu M. PMID: 38990731; PMCID: PMC11444891.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice. bioRxiv. 2024 Jun 13. Thorwald M, Godoy-Lugo JA, Garcia G, Silva J, Kim M, Christensen A, Mack WJ, Head E, O'Day PA, Benayoun BA, Morgan TE, Pike CJ, Higuchi-Sanabria R, Forman HJ, Finch CE. PMID: 37034750; PMCID: PMC10081222.
      View in: PubMed   Mentions:
    18. Menopause Is More Than Just Loss of Fertility. Public Policy Aging Rep. 2023; 33(4):113-119. Baker C, Benayoun BA. PMID: 38155935; PMCID: PMC10751372.
      View in: PubMed   Mentions: 1  
    19. Sex-dimorphic expression of extracellular matrix genes in mouse bone marrow neutrophils. PLoS One. 2023; 18(11):e0294859. McGill CJ, Ewald CY, Benayoun BA. PMID: 38032907; PMCID: PMC10688658.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. An eQTL-based Approach Reveals Candidate Regulators of LINE-1 RNA Levels in Lymphoblastoid Cells. bioRxiv. 2023 Nov 29. Bravo JI, Mizrahi CR, Kim S, Zhang L, Suh Y, Benayoun BA. PMID: 37645920; PMCID: PMC10461994.
      View in: PubMed   Mentions:
    21. Widespread sex dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues. Cell Rep. 2023 10 31; 42(10):113237. Teefy BB, Lemus AJJ, Adler A, Xu A, Bhala R, Hsu K, Benayoun BA. PMID: 37837621; PMCID: PMC10842523.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. Transcriptomes of aging brain, heart, muscle, and spleen from female and male African turquoise killifish. Sci Data. 2023 10 12; 10(1):695. Xu A, Teefy BB, Lu RJ, Nozownik S, Tyers AM, Valenzano DR, Benayoun BA. PMID: 37828039; PMCID: PMC10570339.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    23. Considerations for reproducible omics in aging research. Nat Aging. 2023 08; 3(8):921-930. Singh PP, Benayoun BA. PMID: 37386258; PMCID: PMC10527412.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    24. Age-maintained human neurons demonstrate a developmental loss of intrinsic neurite growth ability. bioRxiv. 2023 May 24. Lear BP, Thompson EAN, Rodriguez K, Arndt ZP, Khullar S, Klosa PC, Lu RJ, Morrow CS, Risgaard R, Peterson ER, Teefy BB, Bhattacharyya A, Sousa AMM, Wang D, Benayoun BA, Moore DL. PMID: 37292613; PMCID: PMC10245848.
      View in: PubMed   Mentions:
    25. Widespread sex-dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues. bioRxiv. 2023 May 08. Teefy BB, Lemus AJJ, Adler A, Xu A, Bhala R, Hsu K, Benayoun BA. PMID: 37214847; PMCID: PMC10197525.
      View in: PubMed   Mentions:
    26. Sex-dimorphic expression of extracellular matrix genes in mouse bone marrow neutrophils. bioRxiv. 2023 Apr 06. McGill CJ, Ewald CY, Benayoun BA. PMID: 36909511; PMCID: PMC10002647.
      View in: PubMed   Mentions:
    27. Putting aging on ICE. Cell Metab. 2023 03 07; 35(3):383-385. Teefy BB, Benayoun BA. PMID: 36889279; PMCID: PMC10592682.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. The fidelity of transcription in human cells. Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2210038120. Chung C, Verheijen BM, Zhang X, Huang B, Coakley A, McGann E, Wade E, Dinep-Schneider O, LaGosh J, Anagnostou ME, Simpson S, Thomas K, Ernst M, Rattray A, Lynch M, Kashlev M, Benayoun BA, Li Z, Strathern J, Gout JF, Vermulst M. PMID: 36696440; PMCID: PMC9945944.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model. Transl Med Aging. 2023; 7:1-8. Mehalko K, Kim M, Paye S, Koh K, Lu RJ, Benayoun BA. PMID: 36714222; PMCID: PMC9878709.
      View in: PubMed   Mentions: 3  
    30. Differential Expression Analysis of Nothobranchius furzeri Transposable Elements from RNA-seq Data. Cold Spring Harb Protoc. 2023 01 03; 2023(1):35-47. Teefy B, Malone M, Benayoun BA. PMID: 36223994; PMCID: PMC9812909.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    31. Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish. Genome Res. 2023 01; 33(1):141-153. Teefy BB, Adler A, Xu A, Hsu K, Singh PP, Benayoun BA. PMID: 36577520; PMCID: PMC9977155.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    32. Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2022 10 15; 206(8):1019-1034. Taylor S, Isobe S, Cao A, Contrepois K, Benayoun BA, Jiang L, Wang L, Melemenidis S, Ozen MO, Otsuki S, Shinohara T, Sweatt AJ, Kaplan J, Moonen JR, Marciano DP, Gu M, Miyagawa K, Hayes B, Sierra RG, Kupitz CJ, Del Rosario PA, Hsi A, Thompson AAR, Ariza ME, Demirci U, Zamanian RT, Haddad F, Nicolls MR, Snyder MP, Rabinovitch M. PMID: 35696338; PMCID: PMC9801997.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    33. Adult fibroblasts use aggresomes only in distinct cell-states. Sci Rep. 2022 Sep 02; 12(1):15001. Morrow CS, Arndt ZP, Klosa PC, Peng B, Zewdie EY, Benayoun BA, Moore DL. PMID: 36056070; PMCID: PMC9440096.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    34. Production of MHCII-expressing classical monocytes increases during aging in mice and humans. Aging Cell. 2022 10; 21(10):e13701. Barman PK, Shin JE, Lewis SA, Kang S, Wu D, Wang Y, Yang X, Nagarkatti PS, Nagarkatti M, Messaoudi I, Benayoun BA, Goodridge HS. PMID: 36040389; PMCID: PMC9577948.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    35. Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research. J Vis Exp. 2022 08 09; (186). Teefy BB, Adler A, Bhala R, Benayoun BA. PMID: 36036603; PMCID: PMC9828740.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    36. Single-cell RNA-seq of primary bone marrow neutrophils from female and male adult mice. Sci Data. 2022 07 23; 9(1):442. Kim M, Lu RJ, Benayoun BA. PMID: 35871169; PMCID: PMC9308797.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    37. Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models. Annu Rev Nutr. 2022 08 22; 42:227-250. Chen Y, Kim M, Paye S, Benayoun BA. PMID: 35417195; PMCID: PMC9398923.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    38. Time isn't kind to female T-cells. Nat Aging. 2022 03; 2(3):189-191. McGill CJ, Benayoun BA. PMID: 36157102; PMCID: PMC9496640.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. Functional genomics of inflamm-aging and immunosenescence. Brief Funct Genomics. 2022 01 25; 21(1):43-55. Lu RJ, Wang EK, Benayoun BA. PMID: 33690792; PMCID: PMC8789293.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    40. Protocol for analysis of mouse neutrophil NETosis by flow cytometry. STAR Protoc. 2021 12 17; 2(4):100948. McGill CJ, Lu RJ, Benayoun BA. PMID: 34820637; PMCID: PMC8599168.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    41. NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants. Elife. 2021 08 27; 10. Guerrero GA, Derisbourg MJ, Mayr FA, Wester LE, Giorda M, Dinort JE, Hartman MD, Schilling K, Alonso-De Gennaro MJ, Lu RJ, Benayoun BA, Denzel MS. PMID: 34448454; PMCID: PMC8460253.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    42. Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex and age-related functional regulation. Nat Aging. 2021 08; 1(8):715-733. Lu RJ, Taylor S, Contrepois K, Kim M, Bravo JI, Ellenberger M, Sampathkumar NK, Benayoun BA. PMID: 34514433; PMCID: PMC8425468.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    43. Protocol for isolation of adult mouse ear pinnae-derived primary fibroblasts. STAR Protoc. 2021 06 18; 2(2):100406. Bravo JI, Kim M, Benayoun BA. PMID: 33855308; PMCID: PMC8024749.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    44. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021 01 20; 12(1):470. Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. PMID: 33473109; PMCID: PMC7817689.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    45. A multiomic atlas for the exploration of healthy aging in human monocytes. Nat Aging. 2021 01; 1(1):19-21. Kim M, Benayoun BA. PMID: 37117994.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. Genome-wide surveillance of transcription errors in response to genotoxic stress. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Fritsch C, Gout JF, Haroon S, Towheed A, Chung C, LaGosh J, McGann E, Zhang X, Song Y, Simpson S, Danthi PS, Benayoun BA, Wallace D, Thomas K, Lynch M, Vermulst M. PMID: 33443141; PMCID: PMC7817157.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    47. The microbiome: an emerging key player in aging and longevity. Transl Med Aging. 2020; 4:103-116. Kim M, Benayoun BA. PMID: 32832742; PMCID: PMC7437988.
      View in: PubMed   Mentions: 67  
    48. Transposable elements, circular RNAs and mitochondrial transcription in age-related genomic regulation. Development. 2020 06 11; 147(11). Bravo JI, Nozownik S, Danthi PS, Benayoun BA. PMID: 32527937; PMCID: PMC10680986.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    49. Special issue on "Molecular genetics of aging and longevity": a critical time in the field of geroscience. Hum Genet. 2020 Mar; 139(3):275-276. Benayoun BA, Veitia RA. PMID: 32052140; PMCID: PMC7041886.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Remodeling of the H3 nucleosomal landscape during mouse aging. Transl Med Aging. 2020; 4:22-31. Chen Y, Bravo JI, Son JM, Lee C, Benayoun BA. PMID: 32462102; PMCID: PMC7252472.
      View in: PubMed   Mentions: 18  
    51. Measuring Phagocytosis in Bone Marrow-Derived Macrophages and Peritoneal Macrophages with Aging. Methods Mol Biol. 2020; 2144:161-170. Lu R, Sampathkumar NK, Benayoun BA. PMID: 32410033; PMCID: PMC7286108.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    52. Widespread sex dimorphism in aging and age-related diseases. Hum Genet. 2020 Mar; 139(3):333-356. Sampathkumar NK, Bravo JI, Chen Y, Danthi PS, Donahue EK, Lai RW, Lu R, Randall LT, Vinson N, Benayoun BA. PMID: 31677133; PMCID: PMC7031050.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    53. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019 10; 574(7779):553-558. Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prélot L, Ang CE, Shibuya Y, Benayoun BA, Chang ALS, Wernig M, Wysocka J, Longaker MT, Snyder MP, Brunet A. PMID: 31645721; PMCID: PMC7253295.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    54. MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus. Bioessays. 2019 09; 41(9):e1900046. Benayoun BA, Lee C. PMID: 31378979; PMCID: PMC8224472.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    55. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses. Genome Res. 2019 04; 29(4):697-709. Benayoun BA, Pollina EA, Singh PP, Mahmoudi S, Harel I, Casey KM, Dulken BW, Kundaje A, Brunet A. PMID: 30858345; PMCID: PMC6442391.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
    56. Multi-level remodeling of transcriptional landscapes in aging and longevity. BMB Rep. 2019 Jan; 52(1):86-108. Lai RW, Lu R, Danthi PS, Bravo JI, Goumba A, Sampathkumar NK, Benayoun BA. PMID: 30526773; PMCID: PMC6386224.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    57. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018 09 04; 28(3):516-524.e7. Kim KH, Son JM, Benayoun BA, Lee C. PMID: 29983246; PMCID: PMC6185997.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCells
    58. Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression. Nat Commun. 2017 05 10; 8:14995. Contrepois K, Coudereau C, Benayoun BA, Schuler N, Roux PF, Bischof O, Courbeyrette R, Carvalho C, Thuret JY, Ma Z, Derbois C, Nevers MC, Volland H, Redon CE, Bonner WM, Deleuze JF, Wiel C, Bernard D, Snyder MP, Rübe CE, Olaso R, Fenaille F, Mann C. PMID: 28489069; PMCID: PMC5436145.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    59. Computational inference of a genomic pluripotency signature in human and mouse stem cells. Biol Direct. 2016 09 17; 11:47. Kurum E, Benayoun BA, Malhotra A, George J, Ucar D. PMID: 27639379; PMCID: PMC5027095.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    60. The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan. Cell. 2015 Dec 03; 163(6):1539-54. Valenzano DR, Benayoun BA, Singh PP, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A. PMID: 26638078; PMCID: PMC4684691.
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    61. High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells. Genes Dev. 2015 Dec 01; 29(23):2420-34. Pech MF, Garbuzov A, Hasegawa K, Sukhwani M, Zhang RJ, Benayoun BA, Brockman SA, Lin S, Brunet A, Orwig KE, Artandi SE. PMID: 26584619; PMCID: PMC4691947.
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    62. H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency. Cell. 2015 Nov 19; 163(5):1281-1286. Benayoun BA, Pollina EA, Ucar D, Mahmoudi S, Karra K, Wong ED, Devarajan K, Daugherty AC, Kundaje AB, Mancini E, Hitz BC, Gupta R, Rando TA, Baker JC, Snyder MP, Cherry JM, Brunet A. PMID: 28930648.
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    63. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metab. 2015 Nov 03; 22(5):907-21. Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A. PMID: 26456332; PMCID: PMC4635044.
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    64. Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol. 2015 Oct; 16(10):593-610. Benayoun BA, Pollina EA, Brunet A. PMID: 26373265; PMCID: PMC4736728.
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    65. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell. 2015 Feb 26; 160(5):1013-1026. Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A. PMID: 25684364; PMCID: PMC4344913.
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    66. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell. 2015 Jan 08; 16(1):39-50. Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M. PMID: 25467916; PMCID: PMC4389904.
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    67. H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell. 2014 Jul 31; 158(3):673-88. Benayoun BA, Pollina EA, Ucar D, Mahmoudi S, Karra K, Wong ED, Devarajan K, Daugherty AC, Kundaje AB, Mancini E, Hitz BC, Gupta R, Rando TA, Baker JC, Snyder MP, Cherry JM, Brunet A. PMID: 25083876; PMCID: PMC4137894.
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    68. Males shorten the life span of C. elegans hermaphrodites via secreted compounds. Science. 2014 Jan 31; 343(6170):541-4. Maures TJ, Booth LN, Benayoun BA, Izrayelit Y, Schroeder FC, Brunet A. PMID: 24292626; PMCID: PMC4126796.
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    69. Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation. Oncogene. 2013 May 30; 32(22):2739-46. Benayoun BA, Anttonen M, L'Hôte D, Bailly-Bechet M, Andersson N, Heikinheimo M, Veitia RA. PMID: 22797072.
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    70. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. Hum Mol Genet. 2012 Jul 15; 21(14):3264-74. L'Hôte D, Georges A, Todeschini AL, Kim JH, Benayoun BA, Bae J, Veitia RA. PMID: 22544055.
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    71. The transcription factor encyclopedia. Genome Biol. 2012; 13(3):R24. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. PMID: 22458515; PMCID: PMC3439975.
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    72. Epigenetic memory of longevity in Caenorhabditis elegans. Worm. 2012 Jan 01; 1(1):77-81. Benayoun BA, Brunet A. PMID: 24058828; PMCID: PMC3670177.
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    73. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature. 2011 Oct 19; 479(7373):365-71. Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A. PMID: 22012258; PMCID: PMC3368121.
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    74. SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies. PLoS One. 2011; 6(10):e25463. Georges A, Benayoun BA, Marongiu M, Dipietromaria A, L'Hôte D, Todeschini AL, Auer J, Crisponi L, Veitia RA. PMID: 22022399; PMCID: PMC3192040.
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    75. The transcription factor FOXL2: at the crossroads of ovarian physiology and pathology. Mol Cell Endocrinol. 2012 Jun 05; 356(1-2):55-64. Caburet S, Georges A, L'Hôte D, Todeschini AL, Benayoun BA, Veitia RA. PMID: 21763750.
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    76. A regulatory domain is required for Foxn4 activity during retinogenesis. J Mol Neurosci. 2012 Feb; 46(2):315-23. Lelièvre EC, Benayoun BA, Mahieu L, Roger JE, Sahel JA, Sennlaub F, Veitia RA, Goureau O, Guillonneau X. PMID: 21701787; PMCID: PMC3518883.
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    77. Forkhead transcription factors: key players in health and disease. Trends Genet. 2011 Jun; 27(6):224-32. Benayoun BA, Caburet S, Veitia RA. PMID: 21507500.
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    78. Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase. Hum Mol Genet. 2011 May 01; 20(9):1673-86. Benayoun BA, Georges AB, L'Hôte D, Andersson N, Dipietromaria A, Todeschini AL, Caburet S, Bazin C, Anttonen M, Veitia RA. PMID: 21289058.
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    79. Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G). PLoS One. 2010 Jan 20; 5(1):e8789. Benayoun BA, Caburet S, Dipietromaria A, Georges A, D'Haene B, Pandaranayaka PJ, L'Hôte D, Todeschini AL, Krishnaswamy S, Fellous M, De Baere E, Veitia RA. PMID: 20098707; PMCID: PMC2808356.
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    80. Generic binding sites, generic DNA-binding domains: where does specific promoter recognition come from? FASEB J. 2010 Feb; 24(2):346-56. Georges AB, Benayoun BA, Caburet S, Veitia RA. PMID: 19762556.
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    81. The forkhead factor FOXL2: a novel tumor suppressor? Biochim Biophys Acta. 2010 Jan; 1805(1):1-5. Benayoun BA, Kalfa N, Sultan C, Veitia RA. PMID: 19747961.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    82. The new molecular biology of granulosa cell tumors of the ovary. Genome Med. 2009 Aug 25; 1(8):81. Kalfa N, Veitia RA, Benayoun BA, Boizet-Bonhoure B, Sultan C. PMID: 19725933; PMCID: PMC2768967.
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    83. Towards a functional classification of pathogenic FOXL2 mutations using transactivation reporter systems. Hum Mol Genet. 2009 Sep 01; 18(17):3324-33. Dipietromaria A, Benayoun BA, Todeschini AL, Rivals I, Bazin C, Veitia RA. PMID: 19515849.
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    84. Functional evidence implicating FOXL2 in non-syndromic premature ovarian failure and in the regulation of the transcription factor OSR2. J Med Genet. 2009 Jul; 46(7):455-7. Laissue P, Lakhal B, Benayoun BA, Dipietromaria A, Braham R, Elghezal H, Philibert P, Saâd A, Sultan C, Fellous M, Veitia RA. PMID: 19429596.
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    85. A post-translational modification code for transcription factors: sorting through a sea of signals. Trends Cell Biol. 2009 May; 19(5):189-97. Benayoun BA, Veitia RA. PMID: 19328693.
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    86. FOXL2: at the crossroads of female sex determination and ovarian function. Adv Exp Med Biol. 2009; 665:207-26. Benayoun BA, Dipietromaria A, Bazin C, Veitia RA. PMID: 20429427.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    87. Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations. Hum Mol Genet. 2009 Feb 15; 18(4):632-44. Benayoun BA, Batista F, Auer J, Dipietromaria A, L'Hôte D, De Baere E, Veitia RA. PMID: 19010791.
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    88. The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways. Proteomics. 2008 Aug; 8(15):3118-23. Benayoun BA, Auer J, Caburet S, Veitia RA. PMID: 18604817.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    89. Differential functional effects of novel mutations of the transcription factor FOXL2 in BPES patients. Hum Mutat. 2008 Aug; 29(8):E123-31. Nallathambi J, Laissue P, Batista F, Benayoun BA, Lesaffre C, Moumné L, Pandaranayaka PE, Usha K, Krishnaswamy S, Sundaresan P, Veitia RA. PMID: 18484667.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    90. The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles. Hum Mol Genet. 2008 Oct 15; 17(20):3118-27. Benayoun BA, Caburet S, Dipietromaria A, Bailly-Bechet M, Batista F, Fellous M, Vaiman D, Veitia RA. PMID: 18635577.
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    91. The mutations and potential targets of the forkhead transcription factor FOXL2. Mol Cell Endocrinol. 2008 Jan 30; 282(1-2):2-11. Moumné L, Batista F, Benayoun BA, Nallathambi J, Fellous M, Sundaresan P, Veitia RA. PMID: 18155828.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
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