Kyle M. Hurth, MD, PhD

Title(s)Associate Professor of Clinical Pathology, Medical Director, Immunohistochemistry Laboratory
SchoolKeck School of Medicine of Usc
AddressHC4 1450 San Pablo Street
Health Sciences Campus
Los Angeles CA 90089-9092
Phone+1 323 442 8592
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology. bioRxiv. 2025 Apr 01. Ma QL, Ebright B, Li B, Li J, Galvan J, Sanchez A, Renteln M, Dikeman D, Wang S, Kerman BE, Seidler P, Gutierrez-Grebenkova B, Hjelm BE, Hawes D, Hiniker AE, Hurth KM, Bennett DA, Louie SG, Chui HC, Limon A, Arvanitakis Z, Yassine HN. PMID: 40236242; PMCID: PMC11996316.
      View in: PubMed   Mentions:
    2. A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes. J Neurosurg. 2025 Mar 14; 1-9. Cheok SK, Ruzevick J, Briggs RG, Cote DJ, Shah I, Gomez D, Bove I, Feng JJ, Pangal DJ, Strickland BA, Shiroishi M, Zavros Y, Hurth KM, Mathew A, Garrett NE, Little AS, Laws ER, Castro AV, Horbinski CM, Carmichael JD, Zada G. PMID: 40085941.
      View in: PubMed   Mentions:    Fields:    
    3. The role of plasma metagenomic sequencing in identification of Balamuthia mandrillaris encephalitis. Acta Neuropathol Commun. 2025 Mar 13; 13(1):60. Edminster SY, Rebbe RW, Khatchadourian C, Hurth KM, Mathew AJ, Huss-Bawab J, Shiroishi MS, Clark D, Norgan AP, Butler-Wu SM, Hiniker A. PMID: 40082992; PMCID: PMC11908043.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Association between meningioma consistency and surgical outcomes. J Neurosurg. 2025 May 01; 142(5):1331-1337. Shah I, Chung RS, Liu K, Cote DJ, Briggs RG, Guerra G, Gomez D, Yang M, Feng JJ, Renn A, Shiroishi MS, Hurth K, Peterson R, Zada G. PMID: 39793013.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Successful Multimodal Management of an Aggressive Functional Gonadotropic Pituitary Macroadenoma. AACE Clin Case Rep. 2025 Jan-Feb; 11(1):14-17. Feng JJ, Cannon SM, Cheok SK, Shiroishi MS, Hurth KM, Mathew AJ, Zada G, Carmichael JD. PMID: 39896951; PMCID: PMC11784608.
      View in: PubMed   Mentions: 1  
    6. Intracranial meningioma: A review of recent and emerging data on the utility of preoperative imaging for management. J Neuroimaging. 2024 Sep-Oct; 34(5):527-547. Beutler BD, Lee J, Edminster S, Rajagopalan P, Clifford TG, Maw J, Zada G, Mathew AJ, Hurth KM, Artrip D, Miller AT, Assadsangabi R. PMID: 39113129.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Recurring homozygous ACTN2 variant (p.Arg506Gly) causes a recessive myopathy. Ann Clin Transl Neurol. 2024 Mar; 11(3):629-640. Donkervoort S, Mohassel P, O'Leary M, Bonner DE, Hartley T, Acquaye N, Brull A, Mozaffar T, Saporta MA, Dyment DA, Sampson JB, Pajusalu S, Austin-Tse C, Hurth K, Cohen JS, McWalter K, Warman-Chardon J, Crunk A, Foley AR, Undiagnosed Diseases Network, Mammen AL, Wheeler MT, O'Donnell-Luria A, Bönnemann CG. PMID: 38311799; PMCID: PMC10963296.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Clinical Implications of Pituitary Adenomas Exhibiting Dual Transcription Factor Staining: A Case Series of 27 Patients. World Neurosurg. 2024 02; 182:e62-e66. Bove I, Cheok SK, Feng JJ, Briggs RG, Ruzevick J, Cote DJ, Shah I, Little A, Laws E, Castro AV, Carmichael J, Shiroishi M, Hurth K, Zada G. PMID: 37967742; PMCID: PMC11032010.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis. Clin Cancer Res. 2023 11 01; 29(21):4492-4503. Tew BY, Kalfa AJ, Yang Z, Hurth KM, Simon T, Abnoosian E, Durant ST, Hamerlik P, Salhia B. PMID: 37585496; PMCID: PMC10618650.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. A repository of grade 1 and 2 meningioma MRIs in a public dataset for radiomics reproducibility tests. Med Phys. 2024 Mar; 51(3):2334-2344. Vassantachart A, Cao Y, Shen Z, Cheng K, Gribble M, Ye JC, Zada G, Hurth K, Mathew A, Guzman S, Yang W. PMID: 37815256; PMCID: PMC10939960.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Breast-to-brain metastasis is exacerbated with chemotherapy through blood-cerebrospinal fluid barrier and induces Alzheimer's-like pathology. J Neurosci Res. 2023 12; 101(12):1900-1913. Saatian B, Deshpande K, Herrera R, Sedighi S, Eisenbarth R, Iyer M, Das D, Julian A, Martirosian V, Lowman A, LaViolette P, Remsik J, Boire A, Sankey E, Fecci PE, Shiroishi MS, Chow F, Hurth K, Neman J. PMID: 37787045; PMCID: PMC10769085.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Neurotropism of SARS-CoV-2: A Pathological Examination of Neurosurgical Specimens. Neurosurgery. 2024 02 01; 94(2):379-388. Fujii T, Rennert RC, Hurth KM, Ward PM, Campan M, Mathew AJ, Dubeau L, Wallace WD, Liu CY, Russin JJ. PMID: 37728367.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Prevalence of Frontotemporal Dementia in Females of 5 Hispanic Families With R159H VCP Multisystem Proteinopathy. Neurol Genet. 2023 Feb; 9(1):e200037. Shmara A, Gibbs L, Mahoney RP, Hurth K, Goodwill VS, Cuber A, Im R, Pizzo DP, Brown J, Laukaitis C, Mahajan S, Kimonis V. PMID: 36644447; PMCID: PMC9833818.
      View in: PubMed   Mentions: 6  
    14. Highly Multiplexed Spatially Resolved Proteomic and Transcriptional Profiling of the Glioblastoma Microenvironment Using Archived Formalin-Fixed Paraffin-Embedded Specimens. Mod Pathol. 2023 01; 36(1):100034. Kim Y, Danaher P, Cimino PJ, Hurth K, Warren S, Glod J, Beechem JM, Zada G, McEachron TA. PMID: 36788070; PMCID: PMC9937641.
      View in: PubMed   Mentions: 3     Fields:    
    15. Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case. J Neurosurg Case Lessons. 2022 Aug 22; 4(8). Schönthal AH, Swenson S, Bonney PA, Wagle N, Simmon VF, Mathew AJ, Hurth KM, Chen TC. PMID: 36088606; PMCID: PMC9706323.
      View in: PubMed   Mentions: 6  
    16. Automatic differentiation of Grade I and II meningiomas on magnetic resonance image using an asymmetric convolutional neural network. Sci Rep. 2022 03 09; 12(1):3806. Vassantachart A, Cao Y, Gribble M, Guzman S, Ye JC, Hurth K, Mathew A, Zada G, Fan Z, Chang EL, Yang W. PMID: 35264655; PMCID: PMC8907289.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiol Aging. 2022 04; 112:39-54. Dahl MJ, Mather M, Werkle-Bergner M, Kennedy BL, Guzman S, Hurth K, Miller CA, Qiao Y, Shi Y, Chui HC, Ringman JM. PMID: 35045380; PMCID: PMC8976827.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    18. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 Jul 27; 36(4):109475. Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. PMID: 34320362.
      View in: PubMed   Mentions: 3     Fields:    
    19. Monoclonal Antibody Therapy against Acinetobacter baumannii. Infect Immun. 2021 09 16; 89(10):e0016221. Nielsen TB, Yan J, Slarve M, Lu P, Li R, Ruiz J, Lee B, Burk E, Talyansky Y, Oelschlaeger P, Hurth K, Win W, Luna BM, Bonomo RA, Spellberg B. PMID: 34310884; PMCID: PMC8445169.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    20. Reducing body myopathy associated with the LIM2 p.(His123Arg) FHL1 variant. Clin Neurol Neurosurg. 2021 08; 207:106795. Darki L, Jalali-Sohi A, Guzman S, Mathew AJ, Bucelli RC, Hurth KM, Beydoun SR. PMID: 34273663.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 06 29; 35(13):109302. Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. PMID: 34192534; PMCID: PMC8848833.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    22. Silent corticotroph pituitary adenomas: clinical characteristics, long-term outcomes, and management of disease recurrence. J Neurosurg. 2021 12 01; 135(6):1706-1713. Strickland BA, Shahrestani S, Briggs RG, Jackanich A, Tavakol S, Hurth K, Shiroishi MS, Liu CJ, Carmichael JD, Weiss M, Zada G. PMID: 33962375.
      View in: PubMed   Mentions: 13     Fields:    
    23. Comparative study of neuroendocrine acquisition and biomarker expression between neuroendocrine and usual prostatic carcinoma. Prostate. 2021 06; 81(8):469-477. Xiao GQ, Ho G, Suen C, Hurth KM. PMID: 33848377.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Clinical utility of comprehensive genomic profiling in central nervous system tumors of children and young adults. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab037. Ji J, Kaneva K, Hiemenz MC, Dhall G, Davidson TB, Erdreich-Epstein A, Hawes D, Hurth K, Margol AS, Mathew AJ, Robison NJ, Schmidt RJ, Tran HN, Judkins AR, Cotter JA, Biegel JA. PMID: 33948563; PMCID: PMC8080244.
      View in: PubMed   Mentions: 6  
    25. Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab005. Schönthal AH, Peereboom DM, Wagle N, Lai R, Mathew AJ, Hurth KM, Simmon VF, Howard SP, Taylor LP, Chow F, da Fonseca CO, Chen TC. PMID: 33604574; PMCID: PMC7879254.
      View in: PubMed   Mentions: 13  
    26. Chronic Aspiration Pneumonitis Caused by Spontaneous Cerebrospinal Fluid Fistulae of the Skull Base. Laryngoscope. 2021 03; 131(3):462-466. Or M, Buchanan IA, Sizdahkhani S, Hurth K, Amba S, Seltzer J, Khan RA, Brunswick AS, Wrobel BB, Zada G. PMID: 32449957.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Hemorrhagic Presentation of Rathke Cleft Cysts: A Surgical Case Series. Oper Neurosurg (Hagerstown). 2020 05 01; 18(5):470-479. Schooner L, Wedemeyer MA, Bonney PA, Lin M, Hurth K, Mathew A, Liu CJ, Shiroishi M, Carmichael JD, Weiss MH, Zada G. PMID: 31504863.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Ultra-high field magnetic resonance imaging for localization of corticotropin-secreting pituitary adenomas. Neuroradiology. 2020 Aug; 62(8):1051-1054. Patel V, Liu CJ, Shiroishi MS, Hurth K, Carmichael JD, Zada G, Toga AW. PMID: 32306052.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    29. What Genes Can Tell: A Closer Look at Vestibular Schwannoma. Otol Neurotol. 2020 04; 41(4):522-529. Aaron KA, Manojlovic Z, Tu N, Xu Y, Jin Y, Chang S, Kwok E, Webb M, Hurth K, Friedman RA. PMID: 32176142.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Fatal refractory cardiac arrest as presentation of systemic amyloidosis. Respir Med Case Rep. 2020; 30:101042. Chung P, Wheeler S, Fong A, Hurth K, Yaghmour B. PMID: 32274327; PMCID: PMC7132166.
      View in: PubMed   Mentions: 1  
    31. Surgical management of clinically silent thyrotropin pituitary adenomas: A single center series of 20 patients. J Clin Neurosci. 2020 Jan; 71:70-75. Cyprich J, Donoho DA, Brunswick A, Hurth K, Carmichael JD, Weiss MH, Zada G. PMID: 31668712.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. ZBTB16: A new biomarker for primitive neuroectodermal tumor element / Ewing sarcoma. Pathol Res Pract. 2019 Oct; 215(10):152536. Xiao GQ, Sherrod AE, Hurth KM. PMID: 31326195.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Recurrent Rathke's Cleft Cysts: Incidence and Surgical Management in a Tertiary Pituitary Center over 2 Decades. Oper Neurosurg (Hagerstown). 2019 06 01; 16(6):675-684. Wedemeyer MA, Lin M, Fredrickson VL, Arakelyan A, Bradley D, Donoho DA, Hurth KM, Weiss MH, Carmichael JD, Zada G. PMID: 30247673.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    34. Ruptured Mycotic Aneurysm of the Distal Circulation in a Patient with Mucormycosis Without Direct Skull Base Extension: Case Report. Oper Neurosurg (Hagerstown). 2019 03 01; 16(3):E101-E107. Rangwala SD, Strickland BA, Rennert RC, Ravina K, Bakhsheshian J, Hurth K, Giannotta SL, Russin JJ. PMID: 29800469.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Variability and Lack of Prognostic Value Associated With Atypical Pituitary Adenoma Diagnosis: A Systematic Review and Critical Assessment of the Diagnostic Criteria. Neurosurgery. 2018 10 01; 83(4):602-610. Chesney K, Memel Z, Pangal DJ, Donoho D, Hurth K, Mathew A, Carmichael JD, Zada G. PMID: 29165661.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Quadruple Neoplasms following Radiation Therapy for Congenital Bilateral Retinoblastoma. Ocul Oncol Pathol. 2017 Dec; 4(1):33-37. Szymanski LJ, Sibug Saber ME, Kim JW, Go JL, Zada G, Rao N, Hurth KM. PMID: 29344496; PMCID: PMC5757554.
      View in: PubMed   Mentions: 2  
    37. Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model. J Neurosurg. 2018 03; 128(3):695-700. Wang W, Cho HY, Rosenstein-Sisson R, Marín Ramos NI, Price R, Hurth K, Schönthal AH, Hofman FM, Chen TC. PMID: 28409734.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    38. Solitary Plasmacytoma in the Internal Auditory Canal and Cerebellopontine Angle Mimicking Meningioma. Otol Neurotol. 2016 Dec; 37(10):e400-e401. Lavinsky J, Aaron KA, Christian E, Go JL, Hurth K, Giannotta SL, Friedman RA. PMID: 26457817.
      View in: PubMed   Mentions: 2     Fields:    
    39. "Pistachio" and "Avatar" Green-Blue Discoloration of the Brain. Acad Forensic Pathol. 2016 Mar; 6(1):150-152. Szymanski LJ, Hurth K. PMID: 31239883; PMCID: PMC6474518.
      View in: PubMed   Mentions: 2  
    40. Congenital Acute Myeloid Leukemia with Unique Translocation t(11;19)(q23;p13.3). Cureus. 2015 Jul; 7(7):e289. Yarbrough CK, Bandt SK, Hurth K, Wambach JA, Rao R, Kulkarni S, White FV, Frater JL, Leonard JR. PMID: 26244121; PMCID: PMC4523210.
      View in: PubMed   Mentions:
    41. Whipple's disease masquerades as dementia with Lewy bodies. Alzheimer Dis Assoc Disord. 2015 Jan-Mar; 29(1):85-89. Hurth K, Tarawneh R, Ghoshal N, Benzinger TLS, Clifford DB, Geschwind M, Morris JC, Galvin JE, Schmidt RE, Cairns NJ. PMID: 23995819; PMCID: PMC3938990.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease. J Neural Transm (Vienna). 2014 Feb; 121(2):171-81. Armstrong RA, Kotzbauer PT, Perlmutter JS, Campbell MC, Hurth KM, Schmidt RE, Cairns NJ. PMID: 23996276; PMCID: PMC4041534.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    43. Recurrent adult-onset hypophyseal Langerhans cell histiocytosis after radiotherapy: a case report. J Med Case Rep. 2012 Oct 08; 6:341. Funk RK, Ferraro DJ, Perrin RJ, Hurth KM, Stephens JJ, Mansur DB, Chicoine MR, Simpson JR, Jaboin JJ. PMID: 23043797; PMCID: PMC3492086.
      View in: PubMed   Mentions: 1     Fields:    
    44. Acute presentation of tophaceous myelopathy. J Rheumatol. 2011 Jul; 38(7):1525-6. Levin E, Hurth K, Joshi R, Brasington R. PMID: 21724731.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    45. Bronchial atresia. Radiographics. 2009 Sep-Oct; 29(5):1531-5. Gipson MG, Cummings KW, Hurth KM. PMID: 19755610.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    46. Ligand-induced changes in estrogen receptor conformation as measured by site-directed spin labeling. Biochemistry. 2004 Feb 24; 43(7):1891-907. Hurth KM, Nilges MJ, Carlson KE, Tamrazi A, Belford RL, Katzenellenbogen JA. PMID: 14967030.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. Estrogen receptor dimerization: ligand binding regulates dimer affinity and dimer dissociation rate. Mol Endocrinol. 2002 Dec; 16(12):2706-19. Tamrazi A, Carlson KE, Daniels JR, Hurth KM, Katzenellenbogen JA. PMID: 12456792.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    48. Rapid HPLC screening method for contaminants found in implicated L-tryptophan associated with eosinophilia myalgia syndrome and adulterated rapeseed oil associated with toxic oil syndrome. Biomed Chromatogr. 1998 Sep-Oct; 12(5):255-61. Williamson BL, Tomlinson AJ, Hurth KM, Posada de la Paz M, Gleich GJ, Naylor S. PMID: 9787895.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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