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    Brian Michael Luna, PhD

    TitleInstructor of Research Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    Address1520 SAN PABLO
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 865 3737
    Emailbrianlun@usc.edu
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      Collapse Overview
      In the United States there has been a rapid increase in the disease burden caused by antibiotic resistant members of the ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species. More than 2,000,000 illnesses and 23,000 deaths were attributed to antibiotic resistant infections in the US in 2013, with an added $20 billion dollar cost to the healthcare system. Continued research is needed to understand antibiotic tolerance mechanisms for the purpose of developing the next generation of therapeutics that can subvert these mechanisms.

      I am interested in the study of antibiotic tolerance mechanisms by bacterial pathogens; including both antibiotic resistance and antibiotic persister cell formation. Better understanding of antibiotic tolerance mechanisms will guide improved therapeutic strategies for combating these infections. We use multiple research strategies including synthetic biology, microbial genetics, next-generation sequencing, and preclinical mouse models in our work.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Cheng BL, Nielsen TB, Pantapalangkoor P, Zhao F, Lee JC, Montgomery CP, Luna B, Spellberg B, Daum RS. Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection. Hum Vaccin Immunother. 2017 Apr 19; 1-6. PMID: 28422567.
        View in: PubMed
      2. Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B, Spellberg B. Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges. Clin Microbiol Rev. 2017 Jan; 30(1):409-447. PMID: 27974412.
        View in: PubMed
      3. Kubler A, Larsson C, Luna B, Andrade BB, Amaral EP, Urbanowski M, Orandle M, Bock K, Ammerman NC, Cheung LS, Winglee K, Halushka M, Park JK, Sher A, Friedland JS, Elkington PT, Bishai WR. Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis. J Infect Dis. 2016 Feb 15; 213(4):618-27. PMID: 26416658.
        View in: PubMed
      4. Xu Z, Bagci U, Mansoor A, Kramer-Marek G, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ. Computer-aided pulmonary image analysis in small animal models. Med Phys. 2015 Jul; 42(7):3896-910. PMID: 26133591.
        View in: PubMed
      5. K├╝bler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Mollura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain SK, Kumar NP, Babu S, Sher A, Friedland JS, Elkington PT, Bishai WR. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation. J Pathol. 2015 Feb; 235(3):431-44. PMID: 25186281.
        View in: PubMed
      6. Luna B, Kubler A, Larsson C, Foster B, Bagci U, Mollura DJ, Jain SK, Bishai WR. In vivo prediction of tuberculosis-associated cavity formation in rabbits. J Infect Dis. 2015 Feb 1; 211(3):481-5. PMID: 25117755.
        View in: PubMed
      7. Foster B, Bagci U. Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models. IEEE Trans Biomed Eng. 2014 Mar; 61(3):711-24. PMID: 24235292.
        View in: PubMed
      8. Xu Z, Bagci U, Kubler A, Luna B, Jain S, Bishai WR, Mollura DJ. Computer-aided detection and quantification of cavitary tuberculosis from CT scans. Med Phys. 2013 Nov; 40(11):113701. PMID: 24320475.
        View in: PubMed
      9. Bagci U, Foster B, Miller-Jaster K, Luna B, Dey B, Bishai WR, Jonsson CB, Jain S, Mollura DJ. A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging. EJNMMI Res. 2013; 3(1):55. PMID: 23879987.
        View in: PubMed
      10. Larsson C, Luna B, Ammerman NC, Maiga M, Agarwal N, Bishai WR. Gene expression of Mycobacterium tuberculosis putative transcription factors whiB1-7 in redox environments. PLoS One. 2012; 7(7):e37516. PMID: 22829866.
        View in: PubMed
      11. Luna B, Juhn J, James AA. Injection of dsRNA into female A. aegypti mosquitos. J Vis Exp. 2007; (5):215. PMID: 18979015.
        View in: PubMed
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