Brian Michael Luna, PhD

Title(s)Assistant Professor of Molecular Microbiology and Immunology
SchoolKeck School of Medicine of Usc
AddressNTT 6427A 1441 Eastlake Avenue
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 0261
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    Collapse Overview 
    Collapse Overview
    In the United States there has been a rapid increase in the disease burden caused by antibiotic resistant members of the ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species. More than 2,000,000 illnesses and 23,000 deaths were attributed to antibiotic resistant infections in the US in 2013, with an added $20 billion dollar cost to the healthcare system. Continued research is needed to understand antibiotic tolerance mechanisms for the purpose of developing the next generation of therapeutics that can subvert these mechanisms.

    I am interested in the study of antibiotic tolerance mechanisms by bacterial pathogens; including both antibiotic resistance and antibiotic persister cell formation. Better understanding of antibiotic tolerance mechanisms will guide improved therapeutic strategies for combating these infections. We use multiple research strategies including synthetic biology, microbial genetics, next-generation sequencing, and preclinical mouse models in our work.

    Collapse Research 
    Collapse Research Activities and Funding
    Characterization of Rifabutin Therapy Against Antibiotic-Resistant Bacteria
    NIH R01AI139052Aug 10, 2018 - Jul 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models. Antimicrob Agents Chemother. 2024 Mar 06; 68(3):e0139423. Jiao Y, Yan J, Sutaria DS, Lu P, Vicchiarelli M, Reyna Z, Ruiz-Delgado J, Burk E, Moon E, Shah NR, Spellberg B, Bonomo RA, Drusano GL, Louie A, Luna BM, Bulitta JB. PMID: 38289076; PMCID: PMC10916399.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Clinical assays rapidly predict bacterial susceptibility to monoclonal antibody therapy. JCI Insight. 2024 Jan 23; 9(2). Slarve MJ, Bowler N, Burk E, Yan J, Carlino-MacDonald U, Russo TA, Luna BM, Spellberg B. PMID: 38258902; PMCID: PMC10906227.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics. Antimicrob Agents Chemother. 2024 Feb 07; 68(2):e0139323. Shin E, Zhang Y, Zhou J, Lang Y, Sayed ARM, Werkman C, Jiao Y, Kumaraswamy M, Bulman ZP, Luna BM, Bulitta JB. PMID: 38169309; PMCID: PMC10848756.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens. Sci Transl Med. 2023 10 04; 15(716):eadf9556. Yan J, Nielsen TB, Lu P, Talyansky Y, Slarve M, Reza H, Novakovic B, Netea MG, Keller AE, Warren T, DiGiandomenico A, Sellman BR, Luna BM, Spellberg B. PMID: 37792959; PMCID: PMC10947341.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates. PLoS One. 2023; 18(6):e0287102. Lu P, Alletto F, Lee B, Burk E, Martinez J, Prati F, Caselli E, Spellberg B, Luna B. PMID: 37310985; PMCID: PMC10263351.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Development of a Bispecific Antibody Targeting Clinical Isolates of Acinetobacter baumannii. J Infect Dis. 2023 04 26; 227(9):1042-1049. Nielsen TB, Yan J, Slarve M, Li R, Junge JA, Luna BM, Wilkinson I, Yerramalla U, Spellberg B. PMID: 36617220; PMCID: PMC10319980.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    7. Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice. Antimicrob Agents Chemother. 2023 05 17; 67(5):e0019723. Jiao Y, Yan J, Vicchiarelli M, Sutaria DS, Lu P, Reyna Z, Spellberg B, Bonomo RA, Drusano GL, Louie A, Luna BM, Bulitta JB. PMID: 37022153; PMCID: PMC10190254.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Therapeutic, Humanized Monoclonal Antibody Exhibits Broad Binding and Protective Efficacy against Acinetobacter baumannii. Antimicrob Agents Chemother. 2023 03 16; 67(3):e0008623. Slarve M, Reyna Z, Burk E, Ruiz-Delgado J, Li R, Yan J, Luna B, Spellberg B. PMID: 36853012; PMCID: PMC10019318.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Antimicrobial Susceptibility Testing Performed in RPMI 1640 Reveals Azithromycin Efficacy against Carbapenem-Resistant Acinetobacter baumannii and Predicts In Vivo Outcomes in Galleria mellonella. Antimicrob Agents Chemother. 2023 01 24; 67(1):e0132022. Miller S, Goy K, She R, Spellberg B, Luna B. PMID: 36468875; PMCID: PMC9872712.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Acacia Fiber Protects the Gut from Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Colonization Enabled by Antibiotics. mSphere. 2022 06 29; 7(3):e0007122. Maeusli M, Skandalis N, Lee B, Lu P, Miller S, Yan J, Talyansky Y, Li R, Reyna Z, Guerrero N, Ulhaq A, Slarve M, Theologidis I, Spellberg B, Luna B. PMID: 35582906; PMCID: PMC9241499.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Monoclonal Antibody Requires Immunomodulation for Efficacy Against Acinetobacter baumannii Infection. J Infect Dis. 2021 12 15; 224(12):2133-2147. Nielsen TB, Yan J, Luna BM, Talyansky Y, Slarve M, Bonomo RA, Spellberg B. PMID: 34036366; PMCID: PMC8672769.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. In Vitro Activity of Rifabutin and Rifampin against Antibiotic-Resistant Acinetobacter baumannii, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. mSphere. 2021 12 22; 6(6):e0092021. Lee B, Yan J, Ulhaq A, Miller S, Seo W, Lu P, She R, Spellberg B, Luna B. PMID: 34817233; PMCID: PMC8612264.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    13. Monoclonal Antibody Therapy against Acinetobacter baumannii. Infect Immun. 2021 09 16; 89(10):e0016221. Nielsen TB, Yan J, Slarve M, Lu P, Li R, Ruiz J, Lee B, Burk E, Talyansky Y, Oelschlaeger P, Hurth K, Win W, Luna BM, Bonomo RA, Spellberg B. PMID: 34310884; PMCID: PMC8445169.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    14. Environmental Spread of Antibiotic Resistance. Antibiotics (Basel). 2021 May 27; 10(6). Skandalis N, Maeusli M, Papafotis D, Miller S, Lee B, Theologidis I, Luna B. PMID: 34071771; PMCID: PMC8226744.
      View in: PubMed   Mentions: 19  
    15. Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii. Antimicrob Agents Chemother. 2021 03 18; 65(4). Cheng J, Yan J, Reyna Z, Slarve M, Lu P, Spellberg B, Luna B. PMID: 33468472; PMCID: PMC8097462.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Capsule carbohydrate structure determines virulence in Acinetobacter baumannii. PLoS Pathog. 2021 02; 17(2):e1009291. Talyansky Y, Nielsen TB, Yan J, Carlino-Macdonald U, Di Venanzio G, Chakravorty S, Ulhaq A, Feldman MF, Russo TA, Vinogradov E, Luna B, Wright MS, Adams MD, Spellberg B. PMID: 33529209; PMCID: PMC7880449.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    17. FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development. Antimicrob Agents Chemother. 2020 12 16; 65(1). Byrne JM, Waack U, Weinstein EA, Joshi A, Shurland SM, Iarikov D, Bulitta JB, Diep BA, Guina T, Hope WW, Lawrenz MB, Lepak AJ, Luna BM, Miesel L, Phipps AJ, Walsh TJ, Weiss W, Amini T, Farley JJ. PMID: 33106262; PMCID: PMC7927847.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. Pharmacology, Dosing, and Side Effects of Rifabutin as a Possible Therapy for Antibiotic-Resistant Acinetobacter Infections. Open Forum Infect Dis. 2020 Nov; 7(11):ofaa460. Phillips MC, Wald-Dickler N, Loomis K, Luna BM, Spellberg B. PMID: 33204754; PMCID: PMC7651144.
      View in: PubMed   Mentions: 4  
    19. The Bactericidal Activity and Spore Inhibition Effect of Manuka Honey against Clostridioides Difficile. Antibiotics (Basel). 2020 Oct 09; 9(10). Yu L, Palafox-Rosas R, Luna B, She RC. PMID: 33050172; PMCID: PMC7600471.
      View in: PubMed   Mentions: 4  
    20. A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii. Nat Microbiol. 2020 09; 5(9):1134-1143. Luna B, Trebosc V, Lee B, Bakowski M, Ulhaq A, Yan J, Lu P, Cheng J, Nielsen T, Lim J, Ketphan W, Eoh H, McNamara C, Skandalis N, She R, Kemmer C, Lociuro S, Dale GE, Spellberg B. PMID: 32514072; PMCID: PMC7483275.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    21. Horizontal Gene Transfer of Antibiotic Resistance from Acinetobacter baylyi to Escherichia coli on Lettuce and Subsequent Antibiotic Resistance Transmission to the Gut Microbiome. mSphere. 2020 May 27; 5(3). Maeusli M, Lee B, Miller S, Reyna Z, Lu P, Yan J, Ulhaq A, Skandalis N, Spellberg B, Luna B. PMID: 32461272; PMCID: PMC7253597.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    22. Adjunctive transferrin to reduce the emergence of antibiotic resistance in Gram-negative bacteria. J Antimicrob Chemother. 2019 09 01; 74(9):2631-2639. Luna BM, Ershova K, Yan J, Ulhaq A, Nielsen TB, Hsieh S, Pantapalangkoor P, Vanscoy B, Ambrose P, Rudin S, Hujer K, Bonomo RA, Actis L, Skaar EP, Spellberg B. PMID: 31170282; PMCID: PMC6736376.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Natural history of Acinetobacter baumannii infection in mice. PLoS One. 2019; 14(7):e0219824. Luna BM, Yan J, Reyna Z, Moon E, Nielsen TB, Reza H, Lu P, Bonomo R, Louie A, Drusano G, Bulitta J, She R, Spellberg B. PMID: 31318907; PMCID: PMC6638954.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    24. Vaccines targeting Staphylococcus aureus skin and bloodstream infections require different composition. PLoS One. 2019; 14(6):e0217439. Luna BM, Nielsen TB, Cheng B, Pantapalangkoor P, Yan J, Boyle-Vavra S, Bruhn KW, Montgomery C, Spellberg B, Daum R. PMID: 31181086; PMCID: PMC6557488.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Apotransferrin in Combination with Ciprofloxacin Slows Bacterial Replication, Prevents Resistance Amplification, and Increases Antimicrobial Regimen Effect. Antimicrob Agents Chemother. 2019 05; 63(5). Ambrose PG, VanScoy BD, Luna BM, Yan J, Ulhaq A, Nielsen TB, Rudin S, Hujer K, Bonomo RA, Actis L, Skaar E, Spellberg B. PMID: 30782989; PMCID: PMC6496049.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    26. Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip. 2018 09 11; 18(18):2776-2786. Qiu X, Lombardo JA, Westerhof TM, Pennell M, Ng A, Alshetaiwi H, Luna BM, Nelson EL, Kessenbrock K, Hui EE, Haun JB. PMID: 30090895; PMCID: PMC6171522.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    27. Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia. J Vis Exp. 2018 06 28; (136). Nielsen TB, Yan J, Luna B, Spellberg B. PMID: 30010650; PMCID: PMC6102004.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    28. Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data. Sci Transl Med. 2018 04 04; 10(435). Rifat D, Prideaux B, Savic RM, Urbanowski ME, Parsons TL, Luna B, Marzinke MA, Ordonez AA, DeMarco VP, Jain SK, Dartois V, Bishai WR, Dooley KE. PMID: 29618565; PMCID: PMC5969904.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    29. Joint solution for PET image segmentation, denoising, and partial volume correction. Med Image Anal. 2018 05; 46:229-243. Xu Z, Gao M, Papadakis GZ, Luna B, Jain S, Mollura DJ, Bagci U. PMID: 29627687; PMCID: PMC6080255.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    30. Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE. mBio. 2017 08 22; 8(4). Nielsen TB, Pantapalangkoor P, Yan J, Luna BM, Dekitani K, Bruhn K, Tan B, Junus J, Bonomo RA, Schmidt AM, Everson M, Duncanson F, Doherty TM, Lin L, Spellberg B. PMID: 28830942; PMCID: PMC5565964.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    31. Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis. J Infect Dis. 2017 08 15; 216(4):489-501. Nielsen TB, Pantapalangkoor P, Luna BM, Bruhn KW, Yan J, Dekitani K, Hsieh S, Yeshoua B, Pascual B, Vinogradov E, Hujer KM, Domitrovic TN, Bonomo RA, Russo TA, Lesczcyniecka M, Schneider T, Spellberg B. PMID: 28931235; PMCID: PMC5853763.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    32. Selectable Markers for Use in Genetic Manipulation of Extensively Drug-Resistant (XDR) Acinetobacter baumannii HUMC1. mSphere. 2017 Mar-Apr; 2(2). Luna BM, Ulhaq A, Yan J, Pantapalangkoor P, Nielsen TB, Davies BW, Actis LA, Spellberg B. PMID: 28497114; PMCID: PMC5422034.
      View in: PubMed   Mentions: 11     Fields:    
    33. Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection. Hum Vaccin Immunother. 2017 07 03; 13(7):1609-1614. Cheng BL, Nielsen TB, Pantapalangkoor P, Zhao F, Lee JC, Montgomery CP, Luna B, Spellberg B, Daum RS. PMID: 28422567; PMCID: PMC5512765.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    34. Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges. Clin Microbiol Rev. 2017 01; 30(1):409-447. Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B, Spellberg B. PMID: 27974412; PMCID: PMC5217799.
      View in: PubMed   Mentions: 401     Fields:    Translation:HumansCells
    35. Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis. J Infect Dis. 2016 Feb 15; 213(4):618-27. Kubler A, Larsson C, Luna B, Andrade BB, Amaral EP, Urbanowski M, Orandle M, Bock K, Ammerman NC, Cheung LS, Winglee K, Halushka M, Park JK, Sher A, Friedland JS, Elkington PT, Bishai WR. PMID: 26416658; PMCID: PMC4721912.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    36. Computer-aided pulmonary image analysis in small animal models. Med Phys. 2015 Jul; 42(7):3896-910. Xu Z, Bagci U, Mansoor A, Kramer-Marek G, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ. PMID: 26133591; PMCID: PMC4464065.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation. J Pathol. 2015 Feb; 235(3):431-44. Kübler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Mollura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain SK, Kumar NP, Babu S, Sher A, Friedland JS, Elkington PT, Bishai WR. PMID: 25186281; PMCID: PMC4293239.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    38. In vivo prediction of tuberculosis-associated cavity formation in rabbits. J Infect Dis. 2015 Feb 01; 211(3):481-5. Luna B, Kubler A, Larsson C, Foster B, Bagci U, Mollura DJ, Jain SK, Bishai WR. PMID: 25117755; PMCID: PMC4296171.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    39. Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models. IEEE Trans Biomed Eng. 2014 Mar; 61(3):711-24. Foster B, Bagci U, Dey B, Luna B, Bishai W, Jain S, Mollura DJ. PMID: 24235292; PMCID: PMC4196700.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    40. Computer-aided detection and quantification of cavitary tuberculosis from CT scans. Med Phys. 2013 Nov; 40(11):113701. Xu Z, Bagci U, Kubler A, Luna B, Jain S, Bishai WR, Mollura DJ. PMID: 24320475; PMCID: PMC3815073.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    41. A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging. EJNMMI Res. 2013 Jul 23; 3(1):55. Bagci U, Foster B, Miller-Jaster K, Luna B, Dey B, Bishai WR, Jonsson CB, Jain S, Mollura DJ. PMID: 23879987; PMCID: PMC3734217.
      View in: PubMed   Mentions: 20  
    42. Gene expression of Mycobacterium tuberculosis putative transcription factors whiB1-7 in redox environments. PLoS One. 2012; 7(7):e37516. Larsson C, Luna B, Ammerman NC, Maiga M, Agarwal N, Bishai WR. PMID: 22829866; PMCID: PMC3400605.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    43. Injection of dsRNA into female A. aegypti mosquitos. J Vis Exp. 2007; (5):215. Luna BM, Juhn J, James AA. PMID: 18979015; PMCID: PMC2557097.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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