Frances Chow, MD

Title(s)Assistant Professor of Clinical Neurological Surgery and Neurology
SchoolKeck School of Medicine of Usc
Address2204 Alcazar Street
Health Sciences Campus
Los Angeles CA 90033
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    Collapse Biography 
    Collapse Education and Training
    University of California-BerkeleyBAMolecular & Cell Biology, Neurobiology
    Drexel University College of MedicineMDDoctor of Medicine
    University of California-IrvineInternal Medicine
    University of Southern CaliforniaNeurology
    University of California-Los AngelesNeuro-Oncology
    Collapse Awards and Honors
    Keck School of Medicine of USC2018Outstanding Teaching Award
    Super Doctors2020Rising Stars Award
    Super Doctors2021Rising Stars Award
    Super Doctors2022Rising Stars Award
    Los Angeles Magazine2022Top Doctor Award
    Pasadena Magazine2022Top Doctor Award
    Super Doctors2023Rising Stars Award
    Los Angeles Magazine2023Top Doctor Award

    Collapse Research 
    Collapse Research Activities and Funding
    Epigenetic Determinants of Responsiveness to Immunotherapy in Glioblastoma
    NIH KL2 TR001854
    Role: Principal Investigator
    A Phase 1 and Randomized Phase 2 Study of Selinexor and Temozolomide in Recurrent Glioblastoma
    NCI UM1CA186717
    Role: Principal Investigator, Protocol Chair

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Phase 1 and Randomized Phase 2 Clinical Trial of Selinexor and Temozolomide in Recurrent Glioblastoma Among Adults: The Product of a Successful Team Science Approach. Journal of Clinical and Translational Science. 2023. Chow F, Berens M, Tamir S, Landesman Y, Walker C, Krailo M, Gore S, Portnow J.
    2. Breast to brain metastasis is exacerbated with chemotherapy through blood-cerebral spinal fluid-barrier and induces alzheimer’s-like pathology. Neuro-Oncol. 2022; 24(s7):vii21–vii22. Neman J, Saatian B, Deshpande K, Martisorian V, LaViolette P, Boire A, Chow F, Hurth K, Fecci P, Shiroishi M, Eisenbarth R.
    3. Clinical features and molecular characterization of leptomeningeal disease in patients with high grade glioma. Neuro-Oncol. 2022; 24(s7):vii154–vii155. Shoaf M, Chow F, Xiu J, Glantz M, Aulakh S, Ashley D, Lipp ES, Lopez G, Sumrall A, Walker P, Spetzler D, Nicolaides T, Peters KB.
    4. MR multitasking-based dynamic imaging for cerebrovascular evaluation (MT-DICE): Simultaneous quantification of permeability and leakage-insensitive perfusion by dynamic T 1 / T 2 * mapping. Magn Reson Med. 2023 01; 89(1):161-176. Hu Z, Christodoulou AG, Wang N, Xie Y, Shiroishi MS, Yang W, Zada G, Chow FE, Margol AS, Tamrazi B, Chang EL, Li D, Fan Z. PMID: 36128892; PMCID: PMC9826278.
      View in: PubMed   Mentions:
    5. The Abscopal Effect: Systematic Review in Patients with Brain and Spine Metastases. Neurooncol Adv. 2022. Pangal DJ, Yarovinsky B, Cardinal T, Cote DJ, Ruzevick J, Attenello FJ, Chang EL, Ye J, Neman J, Chow F, Zada G.
    6. Modulating glioblastoma chemotherapy response: Evaluating long non-coding RNA effects on DNA damage response, glioma stem cell function, and hypoxic processes. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac119. Yuan E, Liu K, Lee J, Tsung K, Chow F, Attenello FJ. PMID: 36105389; PMCID: PMC9466271.
      View in: PubMed   Mentions:
    7. Interplay between B cell and GABA metabolism (GABAm) and association with immune evasion in breast carcinoma (BC). Journal of Clinical Oncology. 2022; 16(40):1097. Chow F, Kang I, Yin J, Farrell A, Martirosian V, Jayachandran P, Roussos Tores ET, Lu JM, Lenz HF, Ma CX, McArthur HL, Basho RK, Spetzler D, Neman J.
    8. Test-retest repeatability of high-resolution whole-brain DCE-MRI in high-grade glioma patients. International Society for Magnetic Resonance in Medicine Annual Meeting. 2022. Zhu Z, Bliesener Y, Chow F, Acharya J, Nayak KS.
    9. Two Rare Cases of Glioma in Total Spine with Metastases to Brain. Neurology. 2022; 18(98):3885. Oh D, Kahaliardabili P, Guerrero B, Chow F.
    10. Anaplastic Pleomorphic Xanthoastrocytoma with Extracranial Bone Metastasis: A Case Report and Literature Review. Neurology. 2022; 18(98):1251. Yuan E, Lo E, Vartanians T, Chen T, Chow F.
    11. Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma. Nat Commun. 2021 11 26; 12(1):6938. Lee AH, Sun L, Mochizuki AY, Reynoso JG, Orpilla J, Chow F, Kienzler JC, Everson RG, Nathanson DA, Bensinger SJ, Liau LM, Cloughesy T, Hugo W, Prins RM. PMID: 34836966; PMCID: PMC8626557.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    12. A phase 1 with dose expansion/phase 2 study of selinexor in combination with standard of care therapy for newly diagnosed or recurrent glioblastoma. Neuro-Oncology. 2021; 6(23):vi62-63. Odia Y, Wen P, Mehta M, Colman H, Dunbar E, Butowski N, Harrison R, Schulder M, Boockvar J, Chow F, Kumthekar P, Mason W, Venur V, Plotkin S, Lassman A, Duic P, Tamir S, Li K, Liu Y, Mundy G, Damestani Y, Sbar E, Shah J, Shacham S, Goldlust S.
    13. Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1. Nat Commun. 2021 06 29; 12(1):4031. Lu Y, Ng AHC, Chow FE, Everson RG, Helmink BA, Tetzlaff MT, Thakur R, Wargo JA, Cloughesy TF, Prins RM, Heath JR. PMID: 34188042; PMCID: PMC8241935.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Utilization of Discarded Surgical Tissue from Ultrasonic Aspirators to Establish Patient-Derived Metastatic Brain Tumor Cells: A Guide from the Operating Room to the Research Laboratory. Curr Protoc. 2021 Jun; 1(6):e140. Martirosian V, Deshpande K, Lin M, Jarvis C, Yuan E, Chen TC, Zada G, Giannotta SL, Attenello FJ, Chow F, Neman J. PMID: 34170630; PMCID: PMC8869842.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Complementary and Alternative Medicine for the Treatment of Gliomas: Scoping Review of Clinical Studies, Patient Outcomes, and Toxicity Profiles. World Neurosurg. 2021 07; 151:e682-e692. Pangal DJ, Baertsch H, Kellman EM, Cardinal T, Brunswick A, Rutkowski M, Strickland B, Chow F, Attenello F, Zada G. PMID: 33940275.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. PMID: 33367885; PMCID: PMC7992879.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    17. Comorbid depression in surgical cancer patients associated with non-routine discharge and readmission. Surg Oncol. 2021 Jun; 37:101533. Jarvis CA, Bonney PA, Yuan E, Ding L, Chow F, Kim AW, Mack WJ, Zada G, Attenello FJ. PMID: 33601294.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab005. Schönthal AH, Peereboom DM, Wagle N, Lai R, Mathew AJ, Hurth KM, Simmon VF, Howard SP, Taylor LP, Chow F, da Fonseca CO, Chen TC. PMID: 33604574; PMCID: PMC7879254.
      View in: PubMed   Mentions: 3  
    19. Neoadjuvant PD-1 antibody blockade remodels the immune microenvironment of metastatic brain tumors. Neuro-Oncology. 2020; 2(22):ii212-ii213. Sun L, Kienzler J, Lee A, Chow F, Chavez C, Yong W, Everson R, Kim W, Hugo W, Prins RM.
    20. Single-cell RNAseq of tumor infiltrating immune cells from neoadjuvant anti-PD1 treated GBM patients reveals global transcriptional changes and immunosuppressive adaptive responses by myeloid cells. Neuro-Oncology. 2020; 2(22):ii108-ii109. Lee A, Mochizuki A, Chow F, Reynoso J, Orpilla J, Sun L, Chavez C, Galvez M, Kienzler J, Yong W, Everson R, Nathanson D, Bensinger S, Liau L, Cloughesy T, Hugo W, Prins R.
    21. Validation of response to neoadjuvant anti-PD-1 immunotherapy in recurrent glioblastoma. Neuro-Oncology. 2020; 21(6):vi4-vi5. Chow F, Mochizuki A, Lee A, Galvez M, Orpilla J, Everson R, Liau L, Cloughesy T, Prins R. View Publication.
    22. Targeted next-generation sequencing of 565 neuro-oncology patients at UCLA: A single-institution experience. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa009. Ji MS, Eldred BSC, Liu R, Pianka ST, Molaie D, Kevan B, Pan S, Lai TJ, Nguyen NT, Chow FE, Yong WH, Cox CD, Reeh DN, Li T, Liau LM, Nghiemphu PL, Cloughesy TF, Li G, Lai A. PMID: 32118206; PMCID: PMC7034640.
      View in: PubMed   Mentions: 2  
    23. Neoantigens arising from alternative splicing events may be targeted by tumor infiltrating lymphocytes in glioblastomas. Neuro-Oncology. 2019; 21(6):vi118-vi119. Lee A, Pan Y, Mochizuki A, Galvez M, Chow F, Nathanson D, Wang A, Everson R, Liau L, Xing Y, Prins R. View Publication.
    24. Myeloid populations and the effect of neoadjuvant PD-1 inhibition in the glioblastoma microenvironment: a surfaceomic and transcriptomic dissection at the single-cell level. Neuro-Oncology. 2019; 21(6):vi248. Mochizuki A, Lee A, Orpilla J, Kienzler J, Galvez M, Chow F, Davidson T, Wang A, Everson R, Liau L, Cloughesy T, Prins R. View Publication.
    25. Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease. Front Neurol. 2019; 10:1140. Ding Y, Zhao J, Zhang X, Wang S, Viola KL, Chow FE, Zhang Y, Lippa C, Klein WL, Gong Y. PMID: 31736856; PMCID: PMC6838211.
      View in: PubMed   Mentions: 20  
    26. Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series. CNS Oncol. 2019 06 01; 8(2):CNS35. Liu LY, Ji MS, Nguyen NT, Chow FE, Molaie DM, Pianka ST, Green RM, Liau LM, Ellingson BM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 31293169; PMCID: PMC6713025.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Treatment at Safety-Net Hospitals Is Associated with Delays in Coil Embolization in Patients with Subarachnoid Hemorrhage. World Neurosurg. 2018 Dec; 120:e434-e439. Donoho DA, Patel A, Buchanan IA, Chow F, Ding L, Amar AP, Attenello F, Mack WJ. PMID: 30205228; PMCID: PMC6252127.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. The challenge of distinguishing POEMS from chronic inflammatory demyelinating polyneuropathy. US Neurology. 2018; 2(14):94-7. Chow F, Darki L, Beydoun SR.
    29. Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer's Disease. Neural Plast. 2017; 2017:3270725. Xu L, Ren Z, Chow FE, Tsai R, Liu T, Rizzolio F, Boffo S, Xu Y, Huang S, Lippa CF, Gong Y. PMID: 28458925; PMCID: PMC5385220.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    30. The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition. Am J Alzheimers Dis Other Demen. 2014 Jun; 29(4):303-10. Chow F, Gong Y, Lippa CF. PMID: 24421411.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Molecular characteristics and pathways of Avastin for the treatment of glioblastoma multiforme. Neurosurg Clin N Am. 2012 Jul; 23(3):417-27. Spasic M, Chow F, Tu C, Nagasawa DT, Yang I. PMID: 22748654.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Temozolomide and other potential agents for the treatment of glioblastoma multiforme. Neurosurg Clin N Am. 2012 Apr; 23(2):307-22, ix. Nagasawa DT, Chow F, Yew A, Kim W, Cremer N, Yang I. PMID: 22440874.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
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